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S1462901119307853 | The production and use of Engineered Nanoparticles or materials containing ENPs has increased astonishingly leading to increased exposure to workers and consumers . The invention and applications of new materials either create new opportunities or pose new risks and uncertainties . The uncertainties concerning applicat... | Impacts of ENPs on the ecology and the humans are evaluated. Ethical justifications are provided from the view point of IRG J and EC J. The burden and benefits of ENPs on the environment are identified and discussed. Mitigation strategies in sustaining ENPs for environmental applications are provided. Future research d... |
S1462901119307890 | The textile industry presents one of the most threatening patterns of production concerning the global environmental impact . In this article we investigated the textile fiber composition of women s clothing in the retail trade of Santos through information read on the labels during July 2017 and January 2018 in three ... | We investigated the textile fiber composition of women s clothing in the retail trade of Santos Brazil and we verify that the inspected garments consisted mainly of polyester viscose and cotton fibers. We calculate clothes ecological footprints by multiplying the fibers proportions by their sustainability notes and ada... |
S1462901119308044 | Global environmental change and other site specific pressures are threating coral reefs and the livelihoods of dependent coastal communities . Multiple strategies are used to build the resilience of both coral reefs and reef dependent communities but the effectiveness of these strategies is largely unknown . Using the ... | Multiple strategies used to build resilience of coral reefs and reef dependent communities. Intended and realised social and ecological implications of strategies explored. Disaggregated understanding of ecological and social resilience is needed. Policy must encourage strategies contributing across the social ecologic... |
S1462901119308718 | Water systems are experiencing dynamic societal demands and extreme environmental changes . The integration of modular water systems into existing centralized infrastructures creating hybrid systems could mitigate these challenges by enabling more resilient water management . However the existence of technological alte... | Policy instrument mixes are key for the successful operation of modular water technology within hybrid water systems. Multiple policy instrument configurations exist showing that there is no silver bullet for operating modular technology. Regulatory instruments are relevant for operating modular technology within hybri... |
S1462901119308822 | Despite numerous efforts to promote and implement more integrated approaches coordination problems persist and impede sustainable water governance and management . This paper introduces a framework for guiding a transdisciplinary diagnostic approach to address such coordination problems . The approach aims at addressin... | Framework for complex coordination challenges in water governance and management. Diagnostic approach supports context sensitive assessment. Structured case study comparison enhances strength of diagnosis. |
S1462901119308858 | Traditionally water energy and food resources are governed in many countries by separate sets of laws rules and institutions . However recent studies have increasingly underlined the WEF nexus approach as a framework for coherent holistic and integrated implementation of the Sustainable Development Goals to address fra... | Develops a profile of legal and institutional challenges that arise with a nexus approach to WEF governance from a comparative lens. Identifies the ways in which an integrative legal framework can help close these gaps. Proposes framework for enhancing rule linkage and integrated governance across WEF domains. |
S1462901119309116 | Small scale fishing communities are expected to adapt to fish catch fluctuations linked to global environmental change . Notwithstanding impacts from severe climate events and overexploitation of fisheries resources can compromise functions and resilience of ecosystems and associated species and thereby jeopardize long... | Long term records and artisanal fishers congruently confirmed a substantial decline in fish landings in Tanzania. Overfishing environmental changes and destruction of habitats were perceived the drivers of fish catch declines. Fishers adapt to declining fish stocks by changing their resource use behaviours. Most fisher... |
S1462901119309451 | Ship traffic has nearly tripled in the Canadian Arctic over the past decade and additional growth is expected as climate change continues to increase navigability in the region . In response the Canadian Government is developing Low Impact Shipping Corridors as an adaptation strategy that supports safety and sustainabi... | Climate change and sea ice reduction have influenced an increase in Arctic ship traffic. Climate change and increased Arctic shipping are impacting Inuit livelihoods. Low impact shipping corridors need to consider culturally significant marine areas. Communities recommend changes to the low impact shipping corridors in... |
S1462901119309463 | We elevate the undervalued role of wetland protective services for mitigating disastrous consequences of unprecedented weather related events for human communities . Scientific evidence increasingly reveals that wetlands play critical hydrologic roles in landscapes helping to mitigate flood drought and in some cases fi... | Wetlands can help protect human communities from consequences of extreme weather events. Society has not valued the protective services of wetlands. Coordinated and effective policy action is needed to protect wetlands to protect people. We propose countries take policy action to create national wetland commissions. Co... |
S1462901119309530 | Public perception of climate change can either facilitate or hinder the implementation of climate policies . This perception is dependent on a number of influencing factors called drivers in ways that are still not clearly understood . Our study quantifies the relative strength of drivers of climate change perception t... | We present a new framework to study the drivers of climate change perception. We identify 33 community independent drivers. We quantify the relative importance of the identified drivers. The study of interactions among drivers reveals indirect paths of influence. Indirect paths of influence to climate change perception... |
S1462901119309591 | The partisan divide on climate policy in the United States is well documented . Decarbonizing the energy system is key to addressing climate change and social support for many energy policies is not as starkly partisan as the question of the existence of climate change . In this analysis we blend insights from social p... | Climate change and climate change policies are highly partisan in the U.S. The effect of expressive partisanship on climate change attitudes is unknown. Identity based vs. instrumental accounts of partisan identity. Results are consistent with an identity based perspective on partisanship. |
S1462901119309645 | The last decades have seen changes in the water innovation landscape in Africa with many countries introducing innovative approaches to managing water resources and the provision of water services . However little knowledge exists on how water innovators operate in this changing environment . The objective of this expl... | Dynamics of water innovation are manifested at three levels innovation itself innovating entity and innovation system. Fragmentation of innovation systems and lack of scale up capital are the most important bottlenecks for water innovation. Interactive learning based approaches and risk sharing financing models are key... |
S1462901119309657 | In different parts of the world a variety of initiatives are being implemented to promote water innovation . This paper explores the role of virtual incubators in fostering water related innovations in Africa using the case of VIA Water a Dutch programme that promotes water innovation in African cities . Virtual incuba... | Virtual incubators fill important gaps in the African innovation systems for water. Virtual incubators have inherent limitations to perform some functions in local innovation systems. Virtual incubators should be conceived as structural elements of innovation systems. |
S1462901119309669 | The past years have seen a rising number of initiatives to foster water related innovations around the world . Many of such initiatives take the incubation approach to support individuals or entities with potential for developing marketable water innovations . Despite the growing research on incubation the innovation p... | Innovation activities of water incubatees prior to incubation are in essence informal hardly planned and with little focus. The incubation process increases the degree of formality and predictability of the innovation processes. The incubator support enables incubatees to innovate systematically by linking the differen... |
S1462901119309712 | Scenario planning is a popular decision support method that is increasingly being applied to climate change adaptation . However evaluation of scenario planning for adaptation is lacking . In this paper we summarise a science policy session held at the European Climate Change Adaptation Conference in May 2019 where pra... | Scenario planning for climate adaptation is increasingly popular but has not been evaluated. We present reflections from practitioners at the European Climate Change Adaptation conference. Participatory processes focussed locally over short 20year timeframes were most effective. Scenario planning did not sufficiently e... |
S1467089518300058 | Evaluation of IT value is challenging due to the complex nature of IT impacts and multifaceted interpretations of value . We introduce a conceptual framework for tackling the complexity of IT value evaluation within the scope of a single company . Our study applies design science research with analysis of experiences f... | Conceptual Framework offers a systemic basis for understanding and communicating multifaceted IT value. Conceptual Framework connects multi level system analysis multi logic value judgements and different value explications. The utility of Conceptual Framework is demonstrated in five industrial cases. |
S1467089518300411 | Despite the usefulness of computer assisted audit tools and techniques in increasing audit productivity and reducing costs their adoption by audit firms is low in developing countries . The aim of this study is to investigate whether organizational and environmental factors can help explain CAATTs adoption in less deve... | Computer assisted audit tools and techniques CAATTs adoption in developing countries is low. Developed a research model based on the Technology Organization Environment framework. Found organizational and environmental factors explained CAATTs adoption. |
S146708951830071X | The near universal organizational participation in social media is predicated on the belief there are some tangible or intangible new resources to be had through tweeting pinning posting friending and sharing . We argue the linchpin of any payoff from engagement in social media is a special form of social capital we re... | Social media capital SMC is a special form of social capital with a distinct nature determinants and outcomes. Social media capital is THE proximate resource obtained via social media efforts P1 . Social media capital is observable P2 unequally distributed P3 and built only via messages and connecting actions P4 . SMC ... |
S1467089518300897 | Strategic performance measurement systems are employed by senior management as a means of translating strategy into performance measures . Recent research suggests that this translation can lead managers to focus on personal performance measures as opposed to overall organizational strategya phenomenon referred to as s... | Dashboards play an important role in an organization s SPMS at the operational level. Strategy alignment and interactive management control are the most important constructs. Executive management perceives strategy surrogation positively at the operational levels. |
S1467089518301350 | A third wave of technological advancements which is often referred to as digitalization is affecting organizations across the board . This paper aims to present a comprehensive synthesis of the extant scholarly work on digitalization in the accounting literature . It does so through a systematic literature review that ... | Digitalization is the impetus for increasingly elusive boundaries of accounting. Digitalization is changing power relations. Digitalization raises new issues of knowledge production in decision making. |
S1467089520300191 | Based on a cross sectional field study Reinking et al . propose a complex theoretical model for understanding the characteristics of dashboards that promote use and lead to individual and organizational performance gains . This study tests the theoretical model using survey data collected from 323 middle and upper leve... | Provides strong support and external validity for Reinking et al. 2019 theoretical model. Provides insights into the strategy surrogation concerns that have been raised in literature. Strong association between strategy alignment and interactive controls in dashboards. The extend of dashboard use is mediated by dashboa... |
S1467089520300208 | The gradual but marked decline in the correspondence between aggregated accounting numbers and market valuations such as stock returns is a well documented phenomenon in the research literature . Rapid advances in technology have paved the way for the collection of unprecedented volumes of data . Currently the slow spe... | There is an increasing focus on information items outside of financial reports. Propose a new accounting information system based on REA and resource based view. Operationalized through XBRL which supports hierarchy and is machine readable. Data are tagged with data standards such as resource Audit Data Standards and X... |
S146708952030021X | The PCAOB s audit firm inspections drive audit focus and costs . The PCAOB s 2010 initiated increased emphasis on internal control audit work intensified concern over internal control weaknesses . IT related material weaknesses have emerged as particularly significant with PCAOB reports highlighting on going deficienci... | Fee premiums associated with ITMW linger longer than fee premiums for non IT entity level material weaknesses ELMW. ITMW premiums linger longer than premiums for account specific material weaknesses. Fee premiums by type of internal control weakness remediated is strongest for ITMW linked to data processing integrity. ... |
S1467089520300221 | Digitization is said to strongly disrupt business and professional life . Especially tax consulting has aroused public interest in this respect . Frey and Osborne even go so far as to predict that tax consulting will become obsolete . Although these statements are misleading without further interpretation there is no d... | Digitization is said to disrupt whole occupational areas e.g. the accounting profession. This paper develops a digital maturity framework for the accounting tax consulting industry. This paper takes into account personality when investigating success in digitization. We find that extraversion openness and neuroticism a... |
S1467089520300385 | Given exponential growth in the size of big data its multi channel sources and variability in quality that create challenges concerning cost effective use firms have invested significantly in databases and analytical tools to inform decision making . In this regard one means to avoid the costs associated with producing... | A survey of 84 managers in a supply chain management context. Positive association between Big Data Availability and use in SCM decision making. Big Data Availability positively influences Big Data Prioritization. Big Data Prioritization positively impacts use of big data in SCM decision making. The use of big data in ... |
S1467089520300543 | This study experimentally examines potential non professional investors understanding of a random sample of SOX 404 reports containing both IT weaknesses and non IT weaknesses as reflected in their internal control weakness severity ratings and their accuracy in identifying the reported ICWs . We find that the number o... | Potential investors do not fully understand SOX 404 reports. Perceived rather than reported ICWs are associated with ICW severity assessment. Failing to perceive non ITWs but not ITWs reduces ICW severity assessment. Perception errors are associated with lower readability of SOX 404 reports. Specific non ITWs and ITWs ... |
S1467089520300555 | This study is based on a longitudinal in depth case study conducted in a Portuguese public sector organization where the accountants adopted a strategic business partner role and promoted the implementation of two new accounting information systems under the context of increasing business competition . Given their role... | We analysed the implementation processes of two AIS in a public sector organization. We pointed out the accountants strategic business partner role in AIS implementation processes. We studied the ways accountants exercised power throughout AIS implementations. We offered new insights into AIS research under the topic o... |
S1476927118300550 | Hepatitis C Virus infection is a major public health concern across the globe . At present direct acting antivirals are the treatment of choice . However the long term effect of this therapy has yet to be ascertained . Previously fluoroquinolones have been reported to inhibit HCV replication by targeting NS3 protein . ... | Hepatitis C Virus HCV infection is a major public health concern across the globe. At present direct acting antivirals are the treatment of choice. However the long term effect of this therapy has yet to be ascertained. We have applied a cheminformatics molecular docking approach to identify putative HCV drug inhibitor... |
S1476927118301671 | The genetic information encoded in structural genes is decoded by an intracellular process called gene expression . This mechanism is regulated by epigenetic processes such as histone acetylation . Histone acetylation which happens in nucleosomes exposes DNA to transcription factors . Therefore the correlation between ... | Finding the correlation between histone acetylation marks HAms and transcription factor binding sites TFBSs . Using information theory methods to evaluate the importance of HAms in distinguishing TFBSs and random positions. Using the selected HAms as input features for multilayer perceptron neural network to predict TF... |
S1476927118302524 | In psoriasis skin disease psoriatic cells develop rapidly than the normal healthy cells . This speedy growth causes accumulation of dead skin cells on the skins surface resulting in thick patches of red dry and itchy skin . This patches or psoriatic skin legions may exhibit similar characteristics as healthy skin which... | Objective analysis of psoriasis disease over a larger dataset of 780 images. Implementation of swarm intelligence algorithms to obtain optimum clusters. Effective psoriasis lesion detection using four swarm intelligence techniques. Quantitative analysis of the result using different metrics. Calculation of computationa... |
S1476927118306078 | Plant molecular breeding largely depends on the relationship between molecular markers and major traits . Herein a total of 32 962 genomic simple sequence repeats were detected in the whole genome of chickpea with an average density of 94.93 SSRs Mb . Chickpea chromosomes uniformity test indicated that the genomic SSRs... | Uniformity testing showed that the frequency distribution of the gSSRs was uniformly across the eight chickpea chromosomes. A total of 1798 simple sequence repeats SSRs containing transcript assembly contigs TACs were mapped onto chickpea chromosomes. The chromosomal location and distribution of TAC SSRs appeared to be... |
S1476927118306637 | Multi drug resistance bacteria pose a significant threat to our ability to effectively treat infections due to the development of several antibiotic resistant mechanisms . A major component in the development of the MDR phenotype in MDR bacteria is over expression of different type of efflux pumps which actively pump o... | Twenty six potent bacterial efflux pumps inhibitors EPIs are summarized here. All the EPIs were docked with efflux pumps from five different classes. Molecules were optimized and theoretically analyzed following density functional theory. Electrophilicity and ionization potential of the molecules are important criteria... |
S1476927118307114 | ATP dependent ParE enzyme is as an attractive target for the development of antibacterial agents . Atom based 3D QSAR model AADHR.187 was developed based on the thirty eight | A highly predictive five point 3D QSAR model AADHR.187 was developed. Model was validated by the external data set and enrichment study. We identified five potential hits against. ParE by. pharmacophore based HTVS. 30 ns MD simulation was performed to validate the docking pose. Three new molecules have been proposed ha... |
S1476927118307126 | Post translational modifications are considered important molecular interactions in protein science . One of these modifications is sumoylation whose computational detection has recently become a challenge . In this paper we propose a new computational predictor which makes use of the sine and cosine of backbone torsio... | New computational predictor for detecting sumoylation sites. Combination of the sine and cosine of torsion angles and the accessible surface area. Remarkable performance improvement by undersampling the majority class. Prediction of sumoylation non sumoylation sites using an AdaBoost algorithm. |
S1476927118307242 | This paper proposed an improved simulated annealing algorithm for protein structure optimization based on a three dimensional AB off lattice model . In the algorithm we provided a general formula used for producing initial solution and designed a multivariable disturbance term relating to the parameters of simulated an... | The improved algorithm outperforms those reported algorithms on the testing of artificial protein sequences. The improved algorithm can obtain folding conformations with C. RMSD less than 3.0 from PDB structures for real proteins. space filling model can provide dynamic change of protein folding conformation at atomic ... |
S1476927118307448 | The cyclotides are the largest known family of cyclic proteins which are found in several plant families including Violaceae . They are circular bioactive peptides consisting of 28 37 amino acids which possess a cyclic cystine knot motif and could be useful in biotechnology and drug design as scaffolds for peptide base... | A potentially novel gene product suggested here which may encode a cyclotide like precursor with a conserved ER signal sequence a cysteine rich sequence forming 2 zin. finger motifs and a cyclotide like region containing two highly conserved C residues. studies have provided interesting homologies between the suggested... |
S147692711830803X | Bottom up i.e . molecule to medicine strategy for the discovery of new drugs takes enormous time and cost . In most of the cases inherent toxicity and undesired side effects of the developed drug hinder its way beyond the early stages of development . In this regard the systems pharmacology can play an excellent role b... | A combined computational and experimental approach for rationalization and repurposing of traditional medicine. The method accurately predicts active ingredients of a polyherbal extract or extract from other biological sources . It also computes the molecular mechanism of action of the active ingredients. The results a... |
S1476927118308612 | is declared as antibiotic resistant by WHO with the critical urgency of developing novel antimicrobial therapeutics as drug resistance is the second most dangerous threat after terrorism . Besides many attempts still there is no effective vaccine available against | To predict novel antigenic peptides for vaccine development against. by utilizing reverse vaccinology approach. The whole proteome of. e was analyzed using bioinformatics tools. Eight antigenic proteins were predicted as novel targets for vaccine design against multidrug resistant |
S1476927118309368 | In plants NAC is a class of transcription factors involved in growth regulation and is associated with abiotic stress morphogenesis and metabolism . Celery | A total of 111 putative NAC TFs were found and identified based on celery transcriptome and genome database. The AgNAC TFs were classified into 18 subfamilies and their physicochemical properties were preliminary analyzed. Expression profiles of selected. genes in response to abiotic stress were detected. |
S1476927119300623 | In order to identify the signature genes of tumorigenesis the pattern recognition method was used to analyze the gene methylation data which included only normal and cancer samples and was collected from the TCGA database . Here we analyzed the DNA methylation profiles of the six types of cancer and the ME signature ge... | Focus on the early occurrence of cancer. The efficient and versatile method of gene screening for the occurrence of early cancer. The recognition accuracy and sensitivity greater than 97 for all cancers. The occurrence of early cancer is closely related to immune and inflammatory responses. |
S1476927119300817 | We study the origin of TB epidemic and complex distributions of various populations of TB infection within the stochastic framework . The stochastic nature of this disease infection could be linked to the stochastic behaviour at genome level which is exhibited in SNP distributions of experimentally identified hotspot d... | We propose that any TB epidemic may have high chance of periodic recurrence and can be controlled by optimizing parameters. We studied SNP distributions of experimentally identified drug resistance genes. We try to study sequence evolution of these genes. We found emergence of random clusters driven by demographic stoc... |
S1476927119301185 | Congenital insensitivity to pain classified as a type of hereditary sensory and autonomic neuropathies is a rare disease in which the affected individuals fail to perceive sensation of pain . One of the PR SET Domain Proteins | Whole Exome Sequencing identified reported mutation in. gene in a patient with insensitivity to pain. All 19 PRDM domain containing proteins were structurally analyzed. Some of them cause neurological disorders in human including PRDM12. PRDM12 was further studied through. approaches. |
S1476927119301252 | Motivated by the characteristics of highly clustered single nucleotide polymorphism across the human genome we propose a set of chromosome wise fractal dimensions as a measure for identifying an individual for human polymorphism . The fractal dimension quantifies the degree of clustered distribution of SNPs and represe... | We analyzed genome wide SNPs in individuals from different populations. We proposed a set of chromosome wise fractal dimensions. The fractal dimension quantified the degree of clustered distribution of SNPs. A set of fractal dimension described the genetic variation of global populations. The selected feature model pre... |
S1476927119301550 | Elementary flux mode analysis is a well studied method in constraint based modeling of metabolic networks . In EFM analysis a network is decomposed into minimal functional pathways based on the assumption of balanced metabolic fluxes . In this paper a system architecture is proposed that approximately models the functi... | Proposing a modular system architecture to calculate minimal flux balanced metabolic pathways. The architecture is based on the AND OR graph model. The proposed architecture was implemented on a GPU platform to take advantage of the parallel architecture provided in the GPU based on multiple cores and hierarchical memo... |
S1476927119301951 | Ovarian Cancer is the most occurring gynecological cancer worldwide often diagnosed at a later stage and ultimate results in a high death rate . To overcome this serious health concern it is important to understand the molecular mechanisms and equally significant to identify the putative biomarkers as well as the thera... | We identified 154 DEGs in OVCA tumor and cell line samples. DEGs have been used to investigate hub genes for complex networks. Functional enrichment analysis of miRNAs and TFs of DEGs have been carried out. In various steps the DEGs ACACA ACLY and CSF1R showed significant enrichment and were effectively studied. |
S1476927119302440 | Graphs are powerful structures able to capture topological and semantic information from data hence suitable for modelling a plethora of real world systems . For this reason graph based pattern recognition gained a lot of attention in recent years . In this paper a general purpose classification system in the graphs do... | Novel information granulation and knowledge discovery technique for structured data. Information granules as relevant substructures high sensitivity and specificity . Information granules are further filtered at classification stage suboptimal subset . Tests on real metabolic pathways data classification show remarkabl... |
S1476927119302622 | Metastasis is the main cause of breast cancer lethality especially in early stages led to improvements in therapeutic procedures . Lately by improvements in our perception of biological processes and immune system new classes of vaccines are emerged that grant us the opportunity of designing resolute constructs against... | Investigating and validation of PRAME co expressed genes. Establishing protein protein interaction network of PRAME and enrichment analysis. Design novel multi epitope BC vaccine against PRAME. Prediction and modeling of secondary and tertiary structures of PRAME derived vaccine. In silico validation of the designed co... |
S1476927119302750 | Oncogenic human papilloma viruses are the cause of various types of cancer specifically cervical cancer . L1 protein is the main protein of HPV capsid which targeted in many vaccine producing attempts . However they have not enough coverage on the various high risk HPV types . Therefore having a low cost potent HPV vac... | The vaccine consists of four major sections toll like receptor 4 adjuvant toll like receptor 5 adjuvant and two epitopes. Each section was joined together by appropriate linkers. Different strategies were applied to enhance immunogenicity of peptide vaccine. The vaccine is able to protection of population on all member... |
S1476927119303871 | Aggression is a complex behavior underpinned by cross talk between several biomolecules . To date a composite molecular network of the behavioral disorder has not been constructed . The present study aims to develop the same from the system network analyses recruiting genes with empirical evidence demonstrating their r... | From 275 finally selected repertoire of genes 14 molecular modules were observed. Modules with high gene clustering entail both serotonin and dopamine related pathways. Several novel genes were predicted that potentially contributes in aggression physiology. |
S1476927119303913 | Protein Protein Interaction Network analysis unveils molecular level mechanisms involved in disease condition . To explore the complex regulatory mechanisms behind epilepsy and to address the clinical and biological issues of epilepsy | The result revealed eight pivotal genes like DNM1 CCND1 ITPR1 HRAS SRC BRAF CREBBP SPTAN1 present in epilepsy. This study identified pathways like PI3 kinase VEGF CCKR Ras PDGF Integrin Wnt TGF beta EGF receptor signaling etc. Functional enrichment analysis discloses critical tasks during neuron excitation as a dominat... |
S1476927119303998 | Tamoxifen is a prodrug and cytochrome P450 2C9 has a significant role in the formation of a therapeutically more potent metabolite than tamoxifen . Since CYP2C9 exhibits genetic polymorphism it may contribute to different phenotypic drug response . Moreover it may be misleading if the possibility of heterogeneous clini... | CYP2C9 is involved in the metabolism of tamoxifen evident in the described study. Docking study concludes the formation of 4 hydroxytamoxifen by CYP2C9. MD simulations of CYP2C9 amino acid substitutions 2 3 5 8 11 and 13 bound with tamoxifen exhibit structural changes. Modulations were apparent in the substrate specifi... |
S1476927119304050 | Stem cells are crucial in the field of tissue regeneration and developmental biology . Embryonic stem cells which are pluripotent in nature are derived from the inner cell mass of blastocyst . The gene expression profiles of ESCs and Induced pluripotent stem cells were compared to identify the differences . Spermatogon... | We studied the clustering of gene expression data and co expression modules of different cellular phenotypes. Heat maps generated reflects the distinct expression patterns of cells and also intrinsic status of the cells. The Transcriptome variation among GSCs ESCs and gPSCs was studied using fuzzy cluster network. |
S1476927119304128 | Human African trypanosomiasis also known as sleeping sickness causes millions of deaths worldwide . HAT is primarily transmitted by the vector tsetse fly | We have re annotated the genome of tsetse fly and identified novel miRNAs based on a series of reliable bioinformatics tools. 25 proteins and 35 miRNAs were found to be associated with trypanosome survival. Two miRNAs miR 619 5p and miR 2490 3p were observed to target several critical genes that participated in the inf... |
S1476927119304190 | Glutaredoxins the oxidoreductase proteins are involved in several cellular processes including maintenance of cellular redox potential and iron sulfur homeostasis . The analysis of 503 amino acid sequences from 167 cyanobacterial species led to the identification of four classes of cyanobacterial Grxs i.e . class I II ... | Four classes of Grxs were found in 167 cyanobacteria based on phylogenetic analyses. Two novel active site motifs CPFS and CPFC were identified in class VI Grxs for the first time. Active site and putative glutathione binding site are composed of uncharged amino acids. Protein ligand interaction analysis identified nov... |
S147692711930475X | The Protein Structure Prediction problem comprises among other issues forecasting the three dimensional native structure of proteins using only their primary structure information . Most computational studies in this area use synthetic data instead of real biological data . However the closer to the real world the more... | The proposed method finds optimal folds with maximum number of hydrophobic side chain contacts. The computational effort of the method grows exponentially with the number of hydrophobic amino acids. The linear correlation between the number of hydrophobic side chain contacts and the number of hydrophobic amino acids ma... |
S1476927119304785 | Hepatocellular carcinoma is the major histological form of primary liver cancer . It has usually reached the disease state once the patient is diagnosed since there are no specific symptoms in the early stages of HCC . This fact increases the difficulty of curing HCC . Recently quantities of evidence have shown that ma... | Our algorithm improves the original landscpe DNB method with strong clinical applicability. We identify the critical states of HCC based on the characteristics of the distribution of the sample population. In our study low grade dysplastic and high grade dysplastic were identified as critical states of HCC. |
S1476927119304815 | At present tertiary structure discovery growth rate is lagging far behind discovery of primary structure . The prediction of protein structural class using Machine Learning techniques can help reduce this gap . The Structural Classification of Protein Extended is latest and largest dataset available at present . The pr... | The latest and largest dataset SCOPe 2.07 used along with benchmark datasets ASTRAL 1.73 25PDB and FC699. The Random Forest algorithm uses Primary and Secondary Structure based feature vectors for prediction. The species based features are recognized as sensitive features for predictions. The performance of class and i... |
S1476927119305067 | By using the available expression datasets of mRNAs and small RNAs we constructed and compared the salt responsive gene regulatory networks involving both transcriptional and post transcriptional regulations between model plants rice and Arabidopsis . The salt responsive GRNs involve the transcription factors microRNAs... | Based on public salt related microArray data small RNA seq and degradome sequence we constructed and compared salt response networks in rice and Arabidopsis consisting of miRNAs genes and transcription factors TFs . In rice more target genes of networks were enriched in development and growth while more stress directly... |
S1476927119305365 | Recent advances in high throughput experimental technologies have generated a huge amount of data on interactions between proteins and nucleic acids . Motivated by the big experimental data several computational methods have been developed either to predict binding sites in a sequence or to determine if an interaction ... | LSTM based model for constructing protein binding RNA sequences. Computationally deriving protein binding motifs from generated RNA sequences. The derived motifs are comparable to experimentally validated motifs. |
S1476927119305511 | Major Histocompatibility Complex is a cell surface glycoprotein that binds to foreign antigens and presents them to T lymphocyte cells on the surface of Antigen Presenting Cells for appropriate immune recognition . Recently studies focusing on peptide based vaccine design have allowed a better understanding of peptide ... | Normal Mode Analysis can be used to estimate the relative importance of mutations of residues. Stability of pMHC complexes is found to depend on both sequence of the bound peptide and type of the MHC allele. It is shown that pMHC complex stability can be varied by substituting peptide residues. |
S1476927119305687 | Metastases are the main cause of death in advanced breast cancer patients . Although chemotherapy and hormone therapy are current treatment strategies drug resistance is frequent and still not completely understood . | Metastases are the main cause of death in advanced breast cancer BC patients. A bioinformatics analysis was performed on BC patients to explore the molecular mechanisms associated with BC metastasis. We identified pathway co expression network that could contribute to understanding the mechanism and development of BC m... |
S1476927119305705 | WRKY genes comprises one among a large clan of transcription factor genes in the plant kingdom playing a fundamental role in the vegetative and reproductive growth development and stress responses of a plant . In spite of several studies on cucumber | Total of 62 putative WRKY genes were identified in cucumber genome and classified in to three major groups Group I IIa IIe and III . Physicochemical properties variants of WD in identified WRKY proteins were analyzed and based on chemical nature WRKY genes are serine rich proteins. STRING analysis were performed for se... |
S1476927119305845 | High mobility group proteins are the major architectural proteins . Among HMG proteins High Mobility Group A is characterized by AT hook motifs which have an affinity for AT rich DNA . In this study we characterized the plant HMGAs from the Poaceae family using | Three major evolutionary clades of Poaceae HMGAs were identified. Poaceae HMGAs from all the clades except clade 2 HMGAs were identified to lack the high affinity type I DNA binding domain. No. of AT hook ATH motif in Poaceae ranges from 3 to 5. The C terminal tail following the last ATH in Poaceae HMGAs is significant... |
S1476927119306206 | The mitochondrial solute carrier genes are highly conserved during vertebrate evolution . In most SLC25 genes of zebrafish chicken mouse and human the introns are located at exactly superimposable positions . In these topographically corresponding introns we studied the composition of the initial and terminal hexanucle... | In this analysis of the zebrafish chicken mouse and human homologous SLC25 gene introns we describe the conservation mutation dynamics of the zebrafish 5ss and 3ss in the evolution to birds and mammals. Mitochondrial solute carrier genes of zebrafish chicken mouse and human the introns are located at exactly superimpos... |
S1476927119306243 | Family based multi locus tests integrate information from individual loci by weighted averaging of the marginal statistics and have been proven to be more efficient and robust than the single locus tests in genetic association studies . The power depends on how much information the weights can extract from data . The c... | Family based association test FBAT are robust against the population stratification. Multi SNP tests are more powerful than single SNP methods as taking the covariance structure into consideration. Rare variant analysis is crucial to finding genetic causes for some complex diseases. Weighted sum statisitc using LASSO r... |
S1476927119306334 | Members of the let 7 family of miRNAs are well known with their tumor suppressor properties as they are expressed at low levels in several types of human malignancies . Among them let 7b and let 7c have gained special attention due their broad significance . Although the role of let 7b and let 7c have been widely repor... | Let 7b and let 7c were significantly altered in breast cancer. Let 7b and let 7c significantly altered cancer related gene expression. Both miRNA might have crucial roles in breast cancer progression |
S1476927119306504 | Gastric cancer is a common malignant tumor in the clinic with a high mortality rate ranking the first among malignant tumors of the digestive system . Early gastric cancer exhibits no specific clinical symptoms and signs and most of the patients were diagnosed as advanced gastric cancer . The prognosis is poor and the ... | A comprehensive analysis of STAD pathogenesis was conducted. High expression of DERL3 suppresses the invasion migration and proliferation of gastric cancer cells. DERL3 was screened and validated as a candidate diagnostic marker gene of STAD. DERL3 is a potential molecular target for the treatment of STAD. |
S1476927119306607 | The present study was to illustrate the agonistic property of arjungenin and arjunic acid towards farnesoid X receptor protein .The pharmacokinetic properties like molecular interactions absorption distribution metabolism elimination and toxicity of the ligands were checked through | Structure based pharmacophores screening of arjungenin and arjunic acid were predicted potential FXR agonist. ADMET studies of arjungenin and arjunic acid identified as non toxic and has druggable property. Molecular docking studies confirmed arjungenin and arjunic acid as a strong and stable binding towards FXR protei... |
S1476927119307054 | Protein kinases are enzymes acting as a source of phosphate through ATP to regulate protein biological activities by phosphorylating groups of specific amino acids . For that reason inhibiting protein kinases with an active small molecule plays a significant role in cancer treatment . To achieve this aim computational ... | Protein kinases are enzymes acting as a source of phosphate through ATP to regulate protein biological activities. Inhibiting protein kinases with an active small molecule plays a significant role in cancer treatment. To achieve this aim QSAR model is one of the best economical approaches to reduce time and save in cos... |
S147692711930711X | Insight into the key genes of pluripotency in human and their interrelationships is necessary for understanding the underlying mechanism of pluripotency and hence their successful application in regenerative medicine . The recent advances in transcriptomics technologies have created new opportunities to decipher the ge... | Transcriptome profiles of human pluripotent and non pluripotent samples were compared. Identified 498 pluripotency associated genes and 432 differentiation markers. 32 genes identified to be critical for pluripotency. List includes some of the well known stemness genes like NANOG POU5F1 and LIN28. We report several gen... |
S1476927119307297 | Colorectal cancer is one of the most frequent and diagnosed diseases . Accumulating evidences showed that mRNAs and noncoding RNAs play important regulatory roles in tumorigenesis . Identification and determining the relationship between them can help diagnosis and treatment of cancer . Here we analyzed three microarra... | The microarray data analysis was conducted to identify differentially expressed lncRNAs and mRNAs in CRC. The lncRNA miRNA mRNA interactions network analyses let to identify potential contributors involved in CRC pathobiology. The lncRNA miRNA mRNA interactions network analyses might be considered for further experimen... |
S1476927119307601 | The present study is focused on a series of newly synthesized 1 aryl 3 ethyl 3 methylsuccinimide derivatives as potential anticonvulsants . The retention behavior of eleven succinimide derivatives was determined by using reversed phase high performance liquid chromatography and reversed phase high performance thin laye... | A set of newly synthesized succinimides was analyzed by RP HPLC and RP HPTLC. Chromatographic lipophilicity ChL of the studied derivatives was determined. Correlations between their ChL and pharmacokinetic parameters were defined. Their ability to pass the blood brain barrier and other ADMET features were estimated. So... |
S1476927119307972 | The tumor suppressor p53 a transcription factor plays a critical role in many cellular processes including DNA repair and apoptosis and cell cycle arrest . Missense mutations in the p53 have closely related to human cancer . R249S mutation at the p53 core DNA binding domain is frequently observed in hepatocellular carc... | MD simulations were performed to explore the allosteric effect of the R249S mutation on the p53 DBD. R249S mutation allosterically affects the S1 S2 turn at the DNA binding interface. 3. The results can decipher the allosteric regulatory mechanism induced the R249S mutation. |
S1476927119308096 | MicroRNAs have been proved to play an indispensable role in many fundamental biological processes and the dysregulation of miRNAs is closely correlated with human complex diseases . Many studies have focused on the prediction of potential miRNA disease associations . Considering the insufficient number of known miRNA d... | A combinatorial model that combines gradient boosting decision tree with logistic regression GBDT LR was proposed. Gradient boosting decision tree model has the natural advantage to discover new distinguishing features and feature combinations throughout iterative process. GBDT LR obtained AUC of 0.9274 and AUPR of 0.9... |
S1476927119308151 | For a long time the structural basis of TXA2 receptor is limited due to the lack of crystal structure information till the release of the crystal structure of TXA2 receptor which deepens our understanding about ligand recognition and selectivity mechanisms of this physiologically important receptor . In this research w... | The pharmacophores were established using newly resolved crystal structures of human thromboxane A2 receptor. Structure based virtual screening was performed to identify lead molecules with stable dynamics trajectory. Safety of the top molecules was analyzed using publicly available wares like pkCSM and SwissADME. Bind... |
S1476927119308692 | Octopamine is a neurotransmitter in invertebrates and a phenol analog of norepinephrine . The crystallographic and spectral characteristics of octopamine were investigated experimentally and theoretically by applying appropriate level of theory B3LYP D3BJ 6 311 G which reproduced well the experimental bond lengths and ... | A suitable level of theory for the description of octopamine is B3LYP D3BJ 6311G d p . Additional OH group influences the scavenging reaction rates and thermodynamics. The dominant mechanism of DPPH. and ABTS. scavenging is SPLET. Additional bonds are present in 1 2 adrenergic receptors norepinephrine complex. Protein ... |
S1476927119308795 | Angiotensinogen is a key component of renin angiotensin aldosterone system which plays central role in blood pressure homeostasis . Association of AGT polymorphisms have been investigated in different ethnic populations in variety of cardiovascular and non cardiovascular conditions . In this study 354 non synonymous SN... | Highly damaging and pathogenic nsSNPs in human angiotensinogen gene are predicted. Majority of deleterious nsSNPs in human angiotensinogen are evolutionary conserved. Several nsSNPs are found to affect thermodynamic stability and post translational modifications of angiotensinogen. Various nsSNPs are found to destabili... |
S1476927119308837 | The heterocyclic aromatic compounds are primarily used to make pharmaceutical and agrochemicals . In addition these compounds can be chosen as antioxidants corrosion inhibitors electro and opto electronic devices polymer material dye stuff developers etc . On the account of this the heterocyclic aromatic 6 nitro 2 3 di... | Molecular docking has been performed for the biological activity of 6N3DB. Vibrational studies were performed to know chemically active atoms of 6N3DB. HOMO LUMO has been explained for NLO corrosion inhibition and electronic properties. ELF LOL RDG have been visualized and steric vdW intramolecular interactions are exp... |
S147692711930893X | Stearyl coenzyme A desaturase enzyme 1 is a key enzyme that catalyzes the conversion of saturated fatty acids into monounsaturated fatty acids and plays a vital role in lipid metabolism of tumor cells . SCD1 is overexpressed in a variety of malignant tumors and its related inhibitors showed significant anti tumor activ... | Crucial protein ligand interactions of SCD1 receptor antagonists were elucidated. TCMNP ACDNP and IBSNP databases were screened for SCD1 receptor antagonists. MD simulation binding free energy calculation and ADMET prediction were applied to evaluate the virtual screening hits. |
S1476927119309107 | The electron conformational genetic algorithm method had been employed by distinguishing between enantiomers for the first time as a 4D QSAR approach to reveal the pharmacophore and to predict the bioactivity of the dipeptidyl boron compounds . | The biological activities of the stereoisomers of dipeptidyl boron derivatives were successfully distinguished for the first time. EC GA method is capable of distinguishing between the stereoisomers including both enantiomers and diastereomers. The compound 99 which is the diastereomer of 27 is a promising candidate fo... |
S1476927119309181 | With the application of new high throughput sequencing technology a large number of protein sequences is becoming available . Determination of the functional characteristics of these proteins by experiments is an expensive endeavor that requires a lot of time . Furthermore at the organismal level such kind of experimen... | DeepAdd is proposed to predict protein functions using a deep convolutional neural network CNN framework. DeepAdd utilizes a Word2Vec method on defining the set of features to represent a protein. DeepAdd consists of two CNN models with multiple convolution blocks that map the presented protein sequence to two feature ... |
S1476927119309211 | The resistances of matrix protein 2 protein inhibitors and neuraminidase inhibitors for influenza virus have attracted much attention and there is an urgent need for new drug . The antiviral drugs that selectively act on RNA polymerase are less prone to resistance and possess fewer side effects on the patient . Therefo... | Structure based virtual screening was performed to discover influenza virus polymerase inhibitors. Three natural compounds were identified to potentially block the interaction of PA PB1 subunit of influenza virus polymerase. The three compounds showed less or no hepatotoxicity nor plasma protein biding PPB ability. The... |
S1476927119309223 | Obstructive sleep apnoea is a prevalent form of sleep disordered breathing which results in sleep fragmentation and deprivation . Obesity and cardiovascular disorders are the major risk factors associated with OSA . Molecular analysis of the factors associated with OSA could demarcate the clinical analysis pattern in a... | Downregulation of miR 27 and let 7 in OSA. Prediction of miRNA secondary structures. Molecular docking of miRNA and their target genes. CNR1 and CRY2 are better targets for miR 27 and let 7 respectively. Differential expression of miRNA target genes in OSA compared to healthy. |
S1476927119309338 | The underlying molecular characteristics of osteoarthritis a common age related joint disease remains elusive . Here we aimed to identify potential early diagnostic biomarkers and elucidate underlying mechanisms of OA using weighted gene co expression network analysis . We obtained the gene expression profile dataset G... | WGCNA was employed to identify highly correlated gene modules associated with OA synovial membrane. The genes in significant module were enriched in the FoxO signaling pathway and the metabolism of fatty acids and 2 oxocarboxylic acid. 13 hub genes correlated to the development and progression of OA were identified. |
S1476927119309466 | Thyroid carcinoma is one of the most frequent endocrine cancers and has increasing morbidity . Annexin A2 has been found to be highly expressed in various cancers however its expression level and potential mechanism in THCA remain unknown . This study investigated the clinicopathological value and primary molecular mac... | Significant upregulation of ANXA2 expression is evidenced in thyroid carcinoma by multiple detecting approaches. Upregulated ANXA2 is strongly related to the development of thyroid carcinoma. ANXA2 coexpressed genes are mostly enriched in the pathway of extracellular matrix receptor interaction. ANXA2 is a target of mi... |
S1476927119309624 | Calreticulin is localized to and has functions in multiple cellular compartments including the cell surface the endoplasmic reticulum and the extracellular matrix . Mutagenesis studies have identified several residues on a concave sheet surface of CRT critical for CRT binding to carbohydrate and other proteins peptides... | Calreticulin CRT C105A C137A and W319A mutations changed local backbone flexibility and secondary structure. C137A mutation decreased overall size of CRT and formed new inter domain contacts. C105A C137A and W319A mutations changed dynamical correlated motions between residues of CRT. |
S1476927119309831 | the primary causative agent of bacterial panicle blight in rice has been reported as an opportunistic pathogen in patients with chronic infections . This study aimed to re sequence the clinical isolate | Genome of. strain AU6208 was re sequenced. The genome size of strain AU6208 was revealed higher than previous version. Specialty genes including virulent genes were identified. The toxoflavin genes resourced from strain AU6208 have variation compared to strain BGR1. Proteins structural variations were noted among both ... |
S1476927119309909 | Biomarkers are important in the study of tumor processes for early detection and precise treatment . The biomarkers that have been previously detected are not useful for clinical application for primary colorectal carcinoma . The aim of this study was to explore clinically valuable biomarkers of PCRC based on integrate... | The DEGs between PCRC and normal colorectal samples were screened. The DEGs were mainly enriched in extracellular matrix organization bicarbonate transport and cellular response to lipid. Ten hub genes were identified via cytoHubba PYY CXCL3 CXCL11 CXCL8 CXCL12 CCL20 MMP3 P2RY14 NPY1R and CXCL1. The hub genes might pro... |
S147692711931000X | In this study the network pharmacology analysis method was used to explore the bioactive components and targets of Xianlinggubao and further elucidate its potential biological mechanisms of action in the treatment of osteoporosis . The bioactive compounds and predictive targets of XLGB were collected from the tradition... | Identify bioactive components and targets of Xianlinggubao XLGB. Seek common targets for XLGB against Osteoporosis. Understand the underlying action mechanisms of the common targets. |
S1476927119310011 | As part of the type I IFN signaling the 2 5 oligoadenylate synthetase proteins have been involved in the progression of several non viral diseases . Notably OAS has been correlated with immune modulatory functions that promote chronic inflammatory conditions autoimmune disorders cancer and infectious diseases . In spit... | Although OAS proteins exert an antiviral role they are also involved in the progression of several non viral diseases. OAS acts as an immune modulator in chronic inflammatory conditions autoimmune disorders cancer and infectious diseases. OAS enzymes have been ignored as drug targets and to date there are no compounds ... |
S1476927119310035 | Identifying significant protein groups is of great importance for further understanding protein functions . This paper introduces a novel three phase heuristic method for identifying such groups in weighted PPI networks . In the first phase a variable neighborhood search algorithm is applied on a weighted PPI network i... | A novel variable neighborhood search heuristic approach for supporting known complexes in weighted PPI networks by integrating data from different sources PPI networks protein complexes and gene co expression. The proposed approach efficiently searches the overall searching space and is a successful method for solving ... |
S1476927119310072 | Seasonal and pandemic influenza infections are serious threats to public health and the global economy . Since antigenic drift reduces the effectiveness of conventional therapies against the virus herbal medicine has been proposed as an alternative . | Seasonal and pandemic influenza infections are serious threats to public health. Computational research serves as a time saving alternative to the experimental research that yields promising compounds and targets. A network pharmacology based strategy was used to predict potential compounds and target genes from Fritil... |
S1476927119310114 | Accumulating studies have indicated that long non coding RNAs play crucial roles in large amount of biological processes . Predicting lncRNA disease associations can help biologist to understand the molecular mechanism of human disease and benefit for disease diagnosis treatment and prevention . In this paper we introd... | We introduce a graph autoencoder matrix completion to predict associations between lncRNAs and diseases. The imbalance between positive and negative tackled by the cost sensitive neural networks. The experimental results show our method outperforms than other state of the art methods in prediction performance. |
S1476927119310254 | Tripeptidyl peptidase II is primarily considered a house keeping exopeptidase which contributes to the functions of the ubiquitin proteasome system by the maintenance of the cellular amino acid homeostasis . Although functionally well characterised | The identification of the molecular mechanisms driving TPP2 interaction network. Adaptive and innate immunity ID Kit Receptor BCR IL 2 G CSF and NFB signalling . Aerobic glycolysis ID and IL 2 signalling . Tumorigenesis TGF. and p53 signalling MAPKs the control of mTOR . Potential functional link to lung cancer patholo... |
S1476927119310357 | With the development of cancer research various gene expression datasets containing cancer information show an explosive growth trend . In addition due to the continuous maturity of single cell RNA sequencing technology the protein information and pedigree information of a single cell are also continuously mined . It i... | Based on L. norm a robust Extreme Learning Machine method called L. ELM is proposed. Various benchmark datasets downloaded from the UCI database and some image datasets are used to train and test the model. The proposed L. ELM is applied to the classification of cancer samples and single cell data. The proposed method ... |
S1476927119310680 | Partner and localizer of BRCA2 is regarded as a colorectal cancer risk gene but the prognostic implication of PALB2 in CRC remains unclear . In this study we evaluate the prognostic value of the gene copy number alteration and mRNA expression of PALB2 in The Cancer Genome Atlas database and then validated with our data... | We evaluated the prognostic value of PALB2 gene in colorectal cancer. PALB2 gene could be novel prognostic biomarkers for colorectal cancer. Function analyses showed that PALB2 is primarily involved in the DNA repair process. |
S1476927119310710 | Cell wall lytic enzymes as an important biotechnical tool in drug development agriculture and the food industry have attracted more research attention . In this research the accurate identification of cell wall lytic enzymes is one of the key and fundamental tasks . In this study in order to eliminate the inefficiency ... | We identified cell wall lytic enzymes in bioinformatic way to overcome inefficiency of in vitro experiments and provide a website tool by wrapping the proposed model. Our proposed model outperforms the state of the art method in jackknife cross validation test. We comprehensively analyzed the optimal feature set of pro... |
S1476927119310886 | One of the hallmarks of Parkinsons disease a long term neurodegenerative syndrome is the accumulation of alpha synuclein fibrils . Despite numerous studies and efforts inhibition of syn protein aggregation is still a challenge . To overcome this issue we propose an | The first report to identify drugs for repositioning against alpha synuclein aggregation inhibition. 3D ligand based pharmacophore model for alpha synuclein inhibition developed. Key pharmacophore features consist of three HBD two HBA and two AR. New compounds identified as potential alpha synuclein inhibitors. |
S1476927119310904 | Preterm birth defined as a delivery before 37 weeks gestation continues to affect 815 of all pregnancies and is associated with significant neonatal morbidity and mortality . Effective prediction of timing of delivery among women identified to be at significant risk for preterm birth would allow proper implementation o... | Machine learning models are developed to predict of preterm birth for women with cervical cerclage. Data from 274 pregnancies managed with cervical cerclage are used. Model predicts whether the pregnancy will continue beyond 26 weeks gestation. |
S1476927119310928 | The nickel nanoparticles are harmful atmospheric pollutants and the damage caused by them in humans has become a topic of great relevance . In this study we investigate the interaction of the Ni | Nickel nanoparticles Ni. and Ni. are harmful atmospheric pollutants which damage humans. Quantum molecular simulations for the molecular system under realistic thermodynamic conditions NVT are performed. The results show the formation of stable organometallic compounds of the Ni nanoparticles with the DNA nucleic acid ... |
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