row_idx
int64
f_0_ref__32
string
f_1_ref__31
string
f_2_ref__30
string
f_3_ref__29
string
f_4_ref__28
string
f_5_ref__27
string
f_6_ref__26
string
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string
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string
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string
f_10_ref__22
string
f_11_ref__21
string
f_12_ref__20
string
f_13_ref__19
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
f_33_ref__1
string
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string
f_35_ref__3
string
f_36_ref__4
string
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string
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string
f_39_ref__7
string
f_40_ref__8
string
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string
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string
f_43_ref__11
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
f_55_ref__23
string
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string
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string
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string
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string
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string
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f_64_ref__32
string
f_65_alt
string
f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
2,947
C
A
A
C
T
G
C
T
G
C
A
T
A
C
A
T
T
A
T
A
T
C
C
A
T
C
C
A
T
C
C
T
T
T
G
A
A
T
G
T
G
G
C
C
T
A
T
T
A
A
G
A
A
G
G
A
C
A
T
G
C
A
T
G
T
A
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1
2,948
A
T
A
C
A
T
T
A
T
A
T
C
C
A
T
C
C
A
T
C
C
T
T
T
G
A
A
T
G
T
G
G
C
C
T
A
T
T
A
A
G
A
A
G
G
A
C
A
T
G
C
A
T
G
T
T
T
T
A
C
T
T
T
G
G
T
0.117417
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1
2,949
T
G
T
A
G
G
A
T
T
T
G
G
G
T
A
T
C
T
C
T
C
T
T
T
G
C
T
T
C
A
A
G
T
T
G
T
A
A
G
T
G
A
A
C
A
C
T
A
T
T
T
T
C
T
C
T
G
A
A
T
A
T
T
T
T
C
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0
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1
2,950
T
G
T
A
G
G
A
T
T
T
G
G
G
T
A
T
C
T
C
T
C
T
T
T
G
C
T
T
C
A
A
G
T
T
G
T
A
A
G
T
G
A
A
C
A
C
T
A
T
T
T
T
C
T
C
T
G
A
A
T
A
T
T
T
T
A
0.109589
0.033268
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0.007828
0
0.007828
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0.019569
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0.031311
0.048924
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1
2,951
A
A
A
T
A
T
T
C
A
G
A
G
A
A
A
A
T
A
G
T
G
T
T
C
A
C
T
T
A
C
A
A
C
T
T
G
A
A
G
C
A
A
A
G
A
G
A
G
A
T
A
C
C
C
A
A
A
T
C
C
T
A
C
A
T
A
0.109589
0.033268
0.041096
0.072407
0.046967
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0.037182
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0.011742
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0.046967
0.021526
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0.031311
0.007828
0
0.007828
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0.013699
0.050881
0.023483
0.019569
0.009785
0.013699
0.031311
0.048924
0.041096
1
2,952
A
A
G
T
A
A
A
C
T
T
T
G
A
T
A
A
T
G
T
A
G
G
A
T
T
T
G
G
G
T
A
T
C
T
C
T
C
T
T
T
G
C
T
T
C
A
A
G
T
T
G
T
A
A
G
T
G
A
A
C
A
C
T
A
T
G
0.105675
0.031311
0.041096
0.072407
0.04501
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0.005871
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0.046967
0.015656
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0.058708
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0.009785
0
0.007828
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0.015656
0.048924
0.023483
0.021526
0.011742
0.015656
0.031311
0.050881
0.041096
1
2,953
A
G
T
G
T
T
C
A
C
T
T
A
C
A
A
C
T
T
G
A
A
G
C
A
A
A
G
A
G
A
G
A
T
A
C
C
C
A
A
A
T
C
C
T
A
C
A
T
T
A
T
C
A
A
A
G
T
T
T
A
C
T
T
T
C
C
0.105675
0.031311
0.041096
0.072407
0.043053
0.019569
0.005871
0.037182
0.046967
0.015656
0.015656
0.058708
0.02544
0.043053
0.04501
0.023483
0.029354
0.031311
0.009785
0
0.007828
0.001957
0.029354
0.015656
0.048924
0.023483
0.021526
0.011742
0.015656
0.029354
0.050881
0.043053
1
2,954
G
A
A
G
C
A
A
A
G
A
G
A
G
A
T
A
C
C
C
A
A
A
T
C
C
T
A
C
A
T
T
A
T
C
A
A
A
G
T
T
T
A
C
T
T
T
C
A
C
A
T
T
T
T
T
C
C
A
T
C
G
A
G
C
A
C
0.097847
0.033268
0.035225
0.074364
0.046967
0.023483
0.005871
0.037182
0.041096
0.015656
0.015656
0.060665
0.02544
0.043053
0.04501
0.027397
0.029354
0.033268
0.009785
0
0.007828
0.001957
0.031311
0.013699
0.046967
0.021526
0.021526
0.011742
0.015656
0.031311
0.052838
0.043053
1
2,955
G
A
C
T
G
C
T
C
G
A
T
G
G
A
A
A
A
A
T
G
T
G
A
A
A
G
T
A
A
A
C
T
T
T
G
A
T
A
A
T
G
T
A
G
G
A
T
T
T
G
G
G
T
A
T
C
T
C
T
C
T
T
T
G
C
C
0.097847
0.033268
0.035225
0.076321
0.046967
0.021526
0.005871
0.037182
0.039139
0.015656
0.015656
0.060665
0.02544
0.04501
0.04501
0.027397
0.029354
0.035225
0.009785
0
0.007828
0.001957
0.031311
0.013699
0.046967
0.019569
0.021526
0.011742
0.015656
0.031311
0.052838
0.043053
1
2,956
A
T
C
A
A
A
G
T
T
T
A
C
T
T
T
C
A
C
A
T
T
T
T
T
C
C
A
T
C
G
A
G
C
A
G
T
C
T
C
A
T
T
T
C
T
T
T
C
T
A
T
T
A
G
T
T
T
T
A
G
G
C
A
A
T
T
0.107632
0.031311
0.039139
0.080235
0.04501
0.017613
0.005871
0.033268
0.04501
0.015656
0.015656
0.058708
0.027397
0.04501
0.041096
0.02544
0.027397
0.031311
0.009785
0
0.007828
0.001957
0.027397
0.013699
0.054795
0.015656
0.021526
0.011742
0.017613
0.029354
0.054795
0.041096
1
2,957
T
T
G
A
C
A
T
C
G
A
A
G
A
C
G
T
G
A
A
T
A
A
T
C
A
T
A
C
T
G
A
T
T
G
C
C
T
A
A
A
A
C
T
A
A
T
A
G
A
A
A
G
A
A
A
T
G
A
G
A
C
T
G
C
T
G
0.11546
0.031311
0.037182
0.084149
0.043053
0.017613
0.005871
0.031311
0.04501
0.015656
0.015656
0.056751
0.02544
0.041096
0.041096
0.02544
0.02544
0.031311
0.013699
0
0.007828
0.001957
0.031311
0.013699
0.056751
0.013699
0.017613
0.011742
0.017613
0.027397
0.056751
0.041096
1
2,958
C
A
G
G
T
T
T
G
A
C
A
T
C
G
A
A
G
A
C
G
T
G
A
A
T
A
A
T
C
A
T
A
C
T
G
A
T
T
G
C
C
T
A
A
A
A
C
T
A
A
T
A
G
A
A
A
G
A
A
A
T
G
A
G
A
T
0.11546
0.031311
0.037182
0.086106
0.043053
0.015656
0.005871
0.031311
0.048924
0.015656
0.015656
0.056751
0.027397
0.041096
0.041096
0.023483
0.02544
0.029354
0.011742
0
0.007828
0.001957
0.031311
0.015656
0.056751
0.013699
0.017613
0.011742
0.017613
0.027397
0.056751
0.039139
1
2,959
C
A
T
T
T
C
T
T
T
C
T
A
T
T
A
G
T
T
T
T
A
G
G
C
A
A
T
C
A
G
T
A
T
G
A
T
T
A
T
T
C
A
C
G
T
C
T
T
C
G
A
T
G
T
C
A
A
A
C
C
T
G
T
C
A
G
0.11546
0.031311
0.037182
0.086106
0.043053
0.017613
0.005871
0.031311
0.046967
0.015656
0.015656
0.056751
0.02544
0.039139
0.041096
0.023483
0.027397
0.031311
0.011742
0
0.007828
0.001957
0.031311
0.015656
0.056751
0.013699
0.017613
0.011742
0.017613
0.027397
0.056751
0.039139
1
2,960
T
A
T
T
A
G
T
T
T
T
A
G
G
C
A
A
T
C
A
G
T
A
T
G
A
T
T
A
T
T
C
A
C
G
T
C
T
T
C
G
A
T
G
T
C
A
A
A
C
C
T
G
T
C
A
C
C
A
G
T
T
G
T
G
G
G
0.117417
0.031311
0.039139
0.088063
0.043053
0.017613
0.005871
0.031311
0.048924
0.013699
0.015656
0.054795
0.02544
0.039139
0.041096
0.023483
0.02544
0.031311
0.009785
0
0.007828
0.001957
0.031311
0.013699
0.060665
0.015656
0.017613
0.009785
0.019569
0.027397
0.054795
0.037182
1
2,961
T
G
T
C
A
A
A
C
C
T
G
T
C
A
C
C
A
G
T
T
G
T
G
G
T
G
T
T
A
A
T
A
C
A
G
T
G
G
T
A
G
A
A
T
T
T
G
C
C
A
G
C
A
A
A
C
A
A
A
T
T
T
A
C
G
T
0.113503
0.027397
0.039139
0.082192
0.041096
0.017613
0.005871
0.027397
0.050881
0.015656
0.017613
0.062622
0.029354
0.043053
0.037182
0.023483
0.02544
0.031311
0.009785
0
0.007828
0.001957
0.035225
0.013699
0.058708
0.015656
0.019569
0.009785
0.021526
0.02544
0.052838
0.037182
1
2,962
C
A
G
T
T
G
T
G
G
T
G
T
T
A
A
T
A
C
A
G
T
G
G
T
A
G
A
A
T
T
T
G
C
C
A
G
C
A
A
A
C
A
A
A
T
T
T
A
C
G
C
C
C
A
T
G
A
T
G
C
T
G
A
A
A
T
0.117417
0.029354
0.037182
0.082192
0.041096
0.019569
0.005871
0.02544
0.048924
0.017613
0.019569
0.052838
0.029354
0.043053
0.041096
0.023483
0.02544
0.031311
0.009785
0
0.007828
0.001957
0.035225
0.013699
0.058708
0.015656
0.021526
0.009785
0.021526
0.023483
0.050881
0.039139
1
2,963
A
A
T
T
T
T
C
A
G
C
A
T
C
A
T
G
G
G
C
G
T
A
A
A
T
T
T
G
T
T
T
G
C
T
G
G
C
A
A
A
T
T
C
T
A
C
C
A
C
T
G
T
A
T
T
A
A
C
A
C
C
A
C
A
A
T
0.117417
0.029354
0.037182
0.084149
0.041096
0.019569
0.005871
0.02544
0.050881
0.017613
0.017613
0.052838
0.031311
0.043053
0.041096
0.023483
0.02544
0.031311
0.009785
0
0.007828
0.001957
0.033268
0.013699
0.058708
0.015656
0.021526
0.009785
0.019569
0.023483
0.050881
0.039139
1
2,964
G
G
T
T
T
G
T
C
T
T
A
T
A
T
T
C
T
G
G
C
T
A
A
T
T
T
T
C
A
G
C
A
T
C
A
T
G
G
G
C
G
T
A
A
A
T
T
T
G
T
T
T
G
C
T
G
G
C
A
A
A
T
T
C
T
A
0.133072
0.027397
0.041096
0.086106
0.037182
0.019569
0.005871
0.023483
0.050881
0.017613
0.017613
0.046967
0.029354
0.041096
0.041096
0.023483
0.02544
0.031311
0.009785
0
0.007828
0.001957
0.029354
0.013699
0.060665
0.013699
0.021526
0.009785
0.019569
0.021526
0.050881
0.041096
1
2,965
C
T
T
C
T
G
G
T
T
T
G
T
C
T
T
A
T
A
T
T
C
T
G
G
C
T
A
A
T
T
T
T
C
A
G
C
A
T
C
A
T
G
G
G
C
G
T
A
A
A
T
T
T
G
T
T
T
G
C
T
G
G
C
A
A
A
0.133072
0.027397
0.043053
0.084149
0.037182
0.019569
0.005871
0.023483
0.050881
0.019569
0.017613
0.04501
0.029354
0.039139
0.041096
0.023483
0.02544
0.031311
0.009785
0
0.007828
0.001957
0.029354
0.013699
0.060665
0.013699
0.023483
0.009785
0.019569
0.021526
0.052838
0.039139
1
2,966
A
C
A
A
A
T
T
T
A
C
G
C
C
C
A
T
G
A
T
G
C
T
G
A
A
A
A
T
T
A
G
C
C
A
G
A
A
T
A
T
A
A
G
A
C
A
A
A
C
C
A
G
A
A
G
C
A
C
A
T
T
C
A
T
G
A
0.129159
0.02544
0.04501
0.082192
0.037182
0.019569
0.005871
0.02544
0.050881
0.019569
0.017613
0.04501
0.029354
0.039139
0.041096
0.02544
0.02544
0.031311
0.009785
0
0.007828
0.001957
0.031311
0.013699
0.060665
0.013699
0.023483
0.009785
0.019569
0.023483
0.050881
0.039139
1
2,967
T
C
A
T
G
A
A
T
G
T
G
C
T
T
C
T
G
G
T
T
T
G
T
C
T
T
A
T
A
T
T
C
T
G
G
C
T
A
A
T
T
T
T
C
A
G
C
A
T
C
A
T
G
G
G
C
G
T
A
A
A
T
T
T
G
C
0.129159
0.02544
0.04501
0.082192
0.037182
0.019569
0.005871
0.02544
0.050881
0.019569
0.019569
0.043053
0.029354
0.039139
0.041096
0.02544
0.02544
0.031311
0.009785
0
0.007828
0.001957
0.031311
0.013699
0.060665
0.013699
0.023483
0.009785
0.019569
0.023483
0.050881
0.039139
1
2,968
C
C
A
T
G
A
T
G
C
T
G
A
A
A
A
T
T
A
G
C
C
A
G
A
A
T
A
T
A
A
G
A
C
A
A
A
C
C
A
G
A
A
G
C
A
C
A
T
T
C
A
T
G
A
T
G
G
A
T
G
G
A
A
T
T
A
0.131115
0.027397
0.04501
0.078278
0.037182
0.019569
0.005871
0.027397
0.050881
0.019569
0.019569
0.043053
0.029354
0.039139
0.039139
0.02544
0.02544
0.029354
0.009785
0
0.007828
0.001957
0.033268
0.013699
0.060665
0.013699
0.023483
0.009785
0.019569
0.023483
0.050881
0.039139
1
2,969
G
A
T
G
C
T
G
A
A
A
A
T
T
A
G
C
C
A
G
A
A
T
A
T
A
A
G
A
C
A
A
A
C
C
A
G
A
A
G
C
A
C
A
T
T
C
A
T
G
A
T
G
G
A
T
G
G
A
A
T
T
G
C
T
C
A
0.125245
0.027397
0.04501
0.078278
0.037182
0.019569
0.005871
0.027397
0.050881
0.019569
0.021526
0.04501
0.029354
0.039139
0.039139
0.02544
0.02544
0.029354
0.009785
0
0.007828
0.001957
0.035225
0.013699
0.060665
0.013699
0.023483
0.011742
0.019569
0.023483
0.048924
0.039139
1
2,970
G
A
T
G
C
T
G
A
A
A
A
T
T
A
G
C
C
A
G
A
A
T
A
T
A
A
G
A
C
A
A
A
C
C
A
G
A
A
G
C
A
C
A
T
T
C
A
T
G
A
T
G
G
A
T
G
G
A
A
T
T
G
C
T
C
G
0.125245
0.027397
0.04501
0.078278
0.037182
0.019569
0.005871
0.027397
0.050881
0.019569
0.021526
0.04501
0.029354
0.039139
0.039139
0.02544
0.02544
0.029354
0.009785
0
0.007828
0.001957
0.035225
0.013699
0.060665
0.013699
0.023483
0.011742
0.019569
0.023483
0.048924
0.039139
1
2,971
A
A
T
T
A
G
C
C
A
G
A
A
T
A
T
A
A
G
A
C
A
A
A
C
C
A
G
A
A
G
C
A
C
A
T
T
C
A
T
G
A
T
G
G
A
T
G
G
A
A
T
T
G
C
T
C
C
T
A
A
A
A
G
G
G
G
0.125245
0.029354
0.04501
0.076321
0.037182
0.021526
0.005871
0.027397
0.048924
0.019569
0.021526
0.046967
0.029354
0.039139
0.041096
0.02544
0.023483
0.029354
0.009785
0
0.007828
0.001957
0.035225
0.011742
0.058708
0.013699
0.02544
0.011742
0.019569
0.023483
0.050881
0.037182
1
2,972
T
T
A
G
C
C
A
G
A
A
T
A
T
A
A
G
A
C
A
A
A
C
C
A
G
A
A
G
C
A
C
A
T
T
C
A
T
G
A
T
G
G
A
T
G
G
A
A
T
T
G
C
T
C
C
T
A
A
A
A
G
G
G
C
A
G
0.125245
0.029354
0.04501
0.076321
0.037182
0.021526
0.005871
0.027397
0.046967
0.019569
0.021526
0.046967
0.029354
0.039139
0.043053
0.02544
0.023483
0.031311
0.009785
0
0.007828
0.001957
0.035225
0.011742
0.056751
0.013699
0.02544
0.011742
0.019569
0.023483
0.050881
0.037182
1
2,973
A
G
C
C
A
G
A
A
T
A
T
A
A
G
A
C
A
A
A
C
C
A
G
A
A
G
C
A
C
A
T
T
C
A
T
G
A
T
G
G
A
T
G
G
A
A
T
T
G
C
T
C
C
T
A
A
A
A
G
G
G
C
A
T
T
T
0.121331
0.029354
0.046967
0.076321
0.037182
0.021526
0.005871
0.027397
0.048924
0.019569
0.021526
0.046967
0.029354
0.039139
0.043053
0.02544
0.023483
0.031311
0.009785
0
0.007828
0.001957
0.035225
0.011742
0.056751
0.013699
0.02544
0.011742
0.019569
0.023483
0.050881
0.037182
1
2,974
A
A
C
C
A
G
A
A
G
C
A
C
A
T
T
C
A
T
G
A
T
G
G
A
T
G
G
A
A
T
T
G
C
T
C
C
T
A
A
A
A
G
G
G
C
A
T
T
C
A
C
A
A
C
C
A
C
C
T
A
A
T
A
C
A
G
0.131115
0.029354
0.04501
0.078278
0.037182
0.021526
0.005871
0.023483
0.048924
0.019569
0.021526
0.04501
0.029354
0.043053
0.043053
0.021526
0.023483
0.031311
0.009785
0
0.007828
0.001957
0.033268
0.011742
0.058708
0.013699
0.02544
0.011742
0.019569
0.021526
0.048924
0.037182
1
2,975
T
T
T
T
C
C
A
T
T
T
G
T
G
T
A
T
T
A
G
G
T
G
G
T
T
G
T
G
A
A
T
G
C
C
C
T
T
T
T
A
G
G
A
G
C
A
A
T
T
C
C
A
T
C
C
A
T
C
A
T
G
A
A
T
G
T
0.146771
0.029354
0.039139
0.078278
0.037182
0.021526
0.005871
0.021526
0.048924
0.017613
0.021526
0.04501
0.029354
0.043053
0.039139
0.021526
0.023483
0.031311
0.009785
0
0.007828
0.001957
0.033268
0.011742
0.056751
0.013699
0.023483
0.011742
0.019569
0.021526
0.052838
0.035225
1
2,976
T
T
T
T
C
C
A
T
T
T
G
T
G
T
A
T
T
A
G
G
T
G
G
T
T
G
T
G
A
A
T
G
C
C
C
T
T
T
T
A
G
G
A
G
C
A
A
T
T
C
C
A
T
C
C
A
T
C
A
T
G
A
A
T
G
A
0.146771
0.029354
0.039139
0.078278
0.037182
0.021526
0.005871
0.021526
0.048924
0.017613
0.021526
0.04501
0.029354
0.043053
0.039139
0.021526
0.023483
0.031311
0.009785
0
0.007828
0.001957
0.033268
0.011742
0.056751
0.013699
0.023483
0.011742
0.019569
0.021526
0.052838
0.035225
1
2,977
T
C
A
T
G
A
T
G
G
A
T
G
G
A
A
T
T
G
C
T
C
C
T
A
A
A
A
G
G
G
C
A
T
T
C
A
C
A
A
C
C
A
C
C
T
A
A
T
A
C
A
C
A
A
A
T
G
G
A
A
A
A
A
A
A
G
0.146771
0.029354
0.041096
0.078278
0.037182
0.021526
0.005871
0.021526
0.04501
0.017613
0.023483
0.04501
0.029354
0.043053
0.039139
0.021526
0.023483
0.031311
0.011742
0
0.007828
0.001957
0.033268
0.009785
0.056751
0.013699
0.023483
0.011742
0.019569
0.021526
0.052838
0.035225
1
2,978
G
G
A
T
G
G
A
A
T
T
G
C
T
C
C
T
A
A
A
A
G
G
G
C
A
T
T
C
A
C
A
A
C
C
A
C
C
T
A
A
T
A
C
A
C
A
A
A
T
G
G
A
A
A
A
A
A
A
G
A
A
A
A
G
T
T
0.146771
0.029354
0.041096
0.078278
0.037182
0.019569
0.005871
0.021526
0.04501
0.017613
0.02544
0.043053
0.027397
0.043053
0.039139
0.021526
0.023483
0.031311
0.011742
0
0.007828
0.001957
0.033268
0.011742
0.056751
0.013699
0.023483
0.011742
0.023483
0.019569
0.052838
0.035225
1
2,979
T
G
G
A
A
T
T
G
C
T
C
C
T
A
A
A
A
G
G
G
C
A
T
T
C
A
C
A
A
C
C
A
C
C
T
A
A
T
A
C
A
C
A
A
A
T
G
G
A
A
A
A
A
A
A
G
A
A
A
A
G
T
C
A
G
T
0.144814
0.029354
0.043053
0.078278
0.037182
0.019569
0.005871
0.021526
0.04501
0.019569
0.02544
0.043053
0.027397
0.043053
0.037182
0.021526
0.023483
0.029354
0.011742
0
0.007828
0.001957
0.033268
0.011742
0.058708
0.013699
0.023483
0.011742
0.023483
0.019569
0.052838
0.035225
1
2,980
C
T
T
T
C
A
T
T
T
T
T
C
T
T
A
C
C
C
T
C
A
T
C
C
C
T
T
C
A
A
A
T
C
G
A
G
A
T
A
A
G
G
C
T
C
T
T
A
G
A
G
G
T
C
T
C
A
G
A
G
C
T
C
T
T
A
0.105675
0.029354
0.043053
0.09002
0.033268
0.015656
0
0.023483
0.048924
0.021526
0.031311
0.07045
0.029354
0.037182
0.046967
0.013699
0.027397
0.011742
0.005871
0
0.003914
0
0.02544
0.029354
0.041096
0.009785
0.039139
0.013699
0.015656
0.019569
0.076321
0.041096
1
2,981
C
T
T
T
C
A
T
T
T
T
T
C
T
T
A
C
C
C
T
C
A
T
C
C
C
T
T
C
A
A
A
T
C
G
A
G
A
T
A
A
G
G
C
T
C
T
T
A
G
A
G
G
T
C
T
C
A
G
A
G
C
T
C
T
T
G
0.105675
0.029354
0.043053
0.09002
0.033268
0.015656
0
0.023483
0.048924
0.021526
0.031311
0.07045
0.029354
0.037182
0.046967
0.013699
0.027397
0.011742
0.005871
0
0.003914
0
0.02544
0.029354
0.041096
0.009785
0.039139
0.013699
0.015656
0.019569
0.076321
0.041096
1
2,982
C
A
C
T
A
A
G
A
G
C
T
C
T
G
A
G
A
C
C
T
C
T
A
A
G
A
G
C
C
T
T
A
T
C
T
C
G
A
T
T
T
G
A
A
G
G
G
A
T
G
A
G
G
G
T
A
A
G
A
A
A
A
A
T
G
C
0.105675
0.029354
0.043053
0.091977
0.033268
0.015656
0
0.023483
0.048924
0.021526
0.031311
0.072407
0.027397
0.037182
0.046967
0.013699
0.027397
0.011742
0.005871
0
0.003914
0
0.02544
0.029354
0.041096
0.009785
0.039139
0.013699
0.013699
0.019569
0.076321
0.041096
1
2,983
T
C
C
C
T
T
C
A
A
A
T
C
G
A
G
A
T
A
A
G
G
C
T
C
T
T
A
G
A
G
G
T
C
T
C
A
G
A
G
C
T
C
T
T
A
G
T
G
T
C
C
T
G
A
G
A
G
A
T
T
T
G
A
T
G
G
0.105675
0.031311
0.043053
0.09002
0.035225
0.015656
0
0.023483
0.048924
0.021526
0.029354
0.07045
0.029354
0.037182
0.048924
0.013699
0.029354
0.011742
0.005871
0
0.003914
0
0.023483
0.029354
0.041096
0.007828
0.039139
0.013699
0.011742
0.021526
0.074364
0.043053
1
2,984
C
T
C
A
G
A
A
C
T
T
G
G
A
G
C
C
A
T
C
A
A
A
T
C
T
C
T
C
A
G
G
A
C
A
C
T
A
A
G
A
G
C
T
C
T
G
A
G
A
C
C
T
C
T
A
A
G
A
G
C
C
T
T
A
T
G
0.109589
0.031311
0.041096
0.091977
0.035225
0.015656
0
0.023483
0.046967
0.017613
0.033268
0.068493
0.031311
0.039139
0.048924
0.011742
0.02544
0.011742
0.005871
0
0.003914
0
0.02544
0.029354
0.041096
0.007828
0.035225
0.013699
0.013699
0.023483
0.074364
0.043053
1
2,985
G
A
G
C
T
C
T
T
A
G
T
G
T
C
C
T
G
A
G
A
G
A
T
T
T
G
A
T
G
G
C
T
C
C
A
A
G
T
T
C
T
G
A
G
T
A
A
C
C
C
A
A
G
G
C
A
T
T
T
G
C
T
G
T
T
T
0.109589
0.033268
0.043053
0.091977
0.037182
0.015656
0
0.02544
0.046967
0.021526
0.033268
0.056751
0.02544
0.037182
0.050881
0.011742
0.02544
0.011742
0.005871
0
0.003914
0
0.029354
0.029354
0.039139
0.009785
0.035225
0.013699
0.015656
0.023483
0.078278
0.039139
1
2,986
T
T
T
A
A
C
A
G
C
A
A
A
T
G
C
C
T
T
G
G
G
T
T
A
C
T
C
A
G
A
A
C
T
T
G
G
A
G
C
C
A
T
C
A
A
A
T
C
T
C
T
C
A
G
G
A
C
A
C
T
A
A
G
A
G
A
0.111546
0.033268
0.041096
0.091977
0.037182
0.015656
0
0.02544
0.046967
0.021526
0.033268
0.056751
0.02544
0.037182
0.048924
0.011742
0.02544
0.011742
0.005871
0
0.003914
0
0.029354
0.029354
0.041096
0.009785
0.035225
0.013699
0.015656
0.023483
0.078278
0.039139
1
2,987
T
T
T
G
T
G
T
G
T
G
C
A
G
G
T
T
T
C
A
T
T
G
G
T
C
A
G
T
T
T
A
A
C
A
G
C
A
A
A
T
G
C
C
T
T
G
G
G
T
T
A
C
T
C
A
G
A
A
C
T
T
G
G
A
G
G
0.123288
0.033268
0.041096
0.097847
0.039139
0.013699
0
0.02544
0.039139
0.021526
0.031311
0.056751
0.02544
0.039139
0.046967
0.009785
0.02544
0.011742
0.005871
0
0.003914
0
0.027397
0.023483
0.039139
0.011742
0.031311
0.009785
0.017613
0.023483
0.086106
0.039139
1
2,988
A
G
A
G
A
C
A
A
A
A
A
T
A
T
G
A
A
C
G
A
T
A
C
C
T
A
C
A
T
C
A
A
C
A
A
T
T
A
A
G
A
A
G
T
C
C
A
G
C
C
A
A
C
A
C
C
A
G
G
C
A
T
T
G
G
G
0.078278
0.033268
0.035225
0.076321
0.046967
0.017613
0.007828
0.021526
0.046967
0.027397
0.011742
0.091977
0.02544
0.060665
0.039139
0.019569
0.021526
0.031311
0.009785
0
0.007828
0.003914
0.035225
0.015656
0.04501
0.02544
0.019569
0.011742
0.013699
0.015656
0.060665
0.043053
1
2,989
A
T
G
A
A
C
G
A
T
A
C
C
T
A
C
A
T
C
A
A
C
A
A
T
T
A
A
G
A
A
G
T
C
C
A
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C
C
A
A
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A
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A
G
G
C
A
T
T
G
G
T
G
A
A
A
T
A
T
G
T
T
T
T
0.072407
0.029354
0.035225
0.082192
0.041096
0.017613
0.007828
0.021526
0.046967
0.027397
0.011742
0.093933
0.02544
0.060665
0.039139
0.017613
0.021526
0.033268
0.009785
0
0.007828
0.003914
0.035225
0.015656
0.048924
0.02544
0.019569
0.011742
0.015656
0.015656
0.060665
0.04501
1
2,990
T
C
A
A
A
C
A
T
A
T
T
T
C
A
C
C
A
A
T
G
C
C
T
G
G
T
G
T
T
G
G
C
T
G
G
A
C
T
T
C
T
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A
T
T
G
T
T
G
A
T
G
T
A
G
G
T
A
T
C
G
T
T
C
C
0.072407
0.029354
0.035225
0.082192
0.041096
0.017613
0.007828
0.021526
0.04501
0.027397
0.013699
0.093933
0.02544
0.060665
0.039139
0.017613
0.021526
0.033268
0.009785
0
0.007828
0.003914
0.037182
0.015656
0.046967
0.02544
0.019569
0.011742
0.015656
0.015656
0.060665
0.04501
1
2,991
A
C
C
A
G
G
C
A
T
T
G
G
T
G
A
A
A
T
A
T
G
T
T
T
G
A
T
A
G
C
C
A
T
A
T
G
C
C
A
C
C
C
A
T
T
T
T
A
G
A
A
G
C
A
T
T
T
C
C
A
G
A
A
T
G
G
0.088063
0.031311
0.033268
0.080235
0.04501
0.015656
0.007828
0.02544
0.039139
0.023483
0.015656
0.09002
0.021526
0.058708
0.039139
0.017613
0.02544
0.031311
0.011742
0
0.007828
0.003914
0.029354
0.015656
0.043053
0.02544
0.021526
0.013699
0.015656
0.019569
0.060665
0.043053
1
2,992
T
G
A
A
A
T
A
T
G
T
T
T
G
A
T
A
G
C
C
A
T
A
T
G
C
C
A
C
C
C
A
T
T
T
T
A
G
A
A
G
C
A
T
T
T
C
C
A
G
A
A
T
G
A
A
A
A
T
G
T
A
A
G
T
G
G
0.09002
0.031311
0.035225
0.078278
0.043053
0.017613
0.007828
0.02544
0.039139
0.023483
0.019569
0.09002
0.019569
0.054795
0.039139
0.017613
0.02544
0.027397
0.005871
0
0.009785
0.005871
0.029354
0.017613
0.04501
0.02544
0.023483
0.013699
0.015656
0.019569
0.060665
0.043053
1
2,993
G
G
T
T
T
T
C
A
C
T
T
A
C
A
T
T
T
T
C
A
T
T
C
T
G
G
A
A
A
T
G
C
T
T
C
T
A
A
A
A
T
G
G
G
T
G
G
C
A
T
A
T
G
G
C
T
A
T
C
A
A
A
C
A
T
G
0.09002
0.029354
0.037182
0.076321
0.043053
0.017613
0.007828
0.02544
0.041096
0.023483
0.019569
0.088063
0.019569
0.054795
0.039139
0.017613
0.02544
0.027397
0.005871
0
0.009785
0.005871
0.029354
0.017613
0.04501
0.027397
0.023483
0.013699
0.015656
0.019569
0.060665
0.043053
1
2,994
C
A
G
A
A
T
G
A
A
A
A
T
G
T
A
A
G
T
G
A
A
A
A
C
C
T
T
G
T
C
A
G
C
A
T
A
T
T
C
C
A
A
C
A
T
C
G
T
C
T
T
A
A
T
C
G
T
C
T
T
T
C
G
C
T
G
0.093933
0.029354
0.041096
0.07045
0.039139
0.019569
0.007828
0.029354
0.039139
0.021526
0.019569
0.091977
0.019569
0.052838
0.039139
0.019569
0.023483
0.029354
0.007828
0
0.009785
0.005871
0.029354
0.017613
0.04501
0.02544
0.023483
0.011742
0.017613
0.021526
0.056751
0.041096
1
2,995
T
C
A
C
C
T
T
T
T
C
T
T
A
A
T
C
T
C
A
C
T
C
A
C
C
A
G
A
G
C
A
C
C
A
C
T
A
C
T
A
A
G
G
A
G
A
A
T
C
A
T
G
A
A
A
A
C
A
A
T
G
A
A
G
G
G
0.076321
0.027397
0.054795
0.066536
0.046967
0.015656
0.003914
0.041096
0.056751
0.023483
0.023483
0.056751
0.031311
0.033268
0.037182
0.031311
0.02544
0.021526
0.005871
0.001957
0.001957
0
0.039139
0.02544
0.043053
0.019569
0.023483
0.007828
0.02544
0.029354
0.068493
0.035225
1
2,996
G
T
T
T
G
A
G
A
C
C
T
T
C
A
T
T
G
T
T
T
T
C
A
T
G
A
T
T
C
T
C
C
T
T
A
G
T
A
G
T
G
G
T
G
C
T
C
T
G
G
T
G
A
G
T
G
A
G
A
T
T
A
A
G
A
C
0.076321
0.027397
0.054795
0.066536
0.04501
0.015656
0.003914
0.039139
0.056751
0.027397
0.023483
0.058708
0.031311
0.035225
0.037182
0.029354
0.02544
0.021526
0.003914
0.001957
0.001957
0
0.041096
0.02544
0.043053
0.019569
0.02544
0.005871
0.02544
0.027397
0.068493
0.035225
1
2,997
A
C
G
T
G
T
T
T
C
C
G
A
A
T
A
G
T
T
G
A
A
C
A
T
A
A
C
T
G
G
T
T
T
G
A
G
A
C
C
T
T
C
A
T
T
G
T
T
T
T
C
A
T
G
A
T
T
C
T
C
C
T
T
A
G
G
0.066536
0.027397
0.054795
0.062622
0.046967
0.015656
0.003914
0.041096
0.062622
0.027397
0.02544
0.054795
0.031311
0.037182
0.035225
0.031311
0.023483
0.019569
0.001957
0.001957
0.001957
0
0.04501
0.033268
0.041096
0.019569
0.02544
0.005871
0.02544
0.029354
0.066536
0.035225
1
2,998
G
A
A
A
A
C
A
A
T
G
A
A
G
G
T
C
T
C
A
A
A
C
C
A
G
T
T
A
T
G
T
T
C
A
A
C
T
A
T
T
C
G
G
A
A
A
C
A
C
G
T
C
C
T
T
C
T
C
A
G
G
T
T
C
C
G
0.066536
0.027397
0.052838
0.056751
0.050881
0.015656
0.003914
0.041096
0.062622
0.027397
0.02544
0.054795
0.031311
0.037182
0.035225
0.035225
0.027397
0.019569
0.001957
0.001957
0.001957
0
0.043053
0.033268
0.041096
0.019569
0.02544
0.005871
0.02544
0.029354
0.060665
0.039139
1
2,999
A
T
G
G
T
G
G
A
A
C
C
T
G
A
G
A
A
G
G
A
C
G
T
G
T
T
T
C
C
G
A
A
T
A
G
T
T
G
A
A
C
A
T
A
A
C
T
G
G
T
T
T
G
A
G
A
C
C
T
T
C
A
T
T
G
A
0.064579
0.029354
0.052838
0.056751
0.050881
0.015656
0.003914
0.043053
0.060665
0.027397
0.02544
0.054795
0.031311
0.037182
0.037182
0.035225
0.027397
0.019569
0.001957
0.001957
0.001957
0
0.043053
0.033268
0.043053
0.019569
0.02544
0.005871
0.02544
0.029354
0.056751
0.039139
1
3,000
C
A
G
A
G
G
A
A
A
A
C
A
A
T
G
G
T
G
G
A
A
C
C
T
G
A
G
A
A
G
G
A
C
G
T
G
T
T
T
C
C
G
A
A
T
A
G
T
T
G
A
A
C
A
T
A
A
C
T
G
G
T
T
T
G
A
0.062622
0.031311
0.052838
0.052838
0.052838
0.015656
0.003914
0.043053
0.060665
0.027397
0.02544
0.048924
0.031311
0.039139
0.037182
0.037182
0.027397
0.021526
0.001957
0.001957
0.001957
0
0.043053
0.033268
0.046967
0.019569
0.02544
0.005871
0.027397
0.027397
0.052838
0.041096
1
3,001
A
A
A
T
C
A
A
T
G
T
G
G
A
A
G
A
A
G
G
C
A
G
A
G
G
A
A
A
A
C
A
A
T
G
G
T
G
G
A
A
C
C
T
G
A
G
A
A
G
G
A
C
G
T
G
T
T
T
C
C
G
A
A
T
A
C
0.062622
0.029354
0.052838
0.052838
0.050881
0.015656
0.003914
0.041096
0.060665
0.029354
0.02544
0.04501
0.031311
0.039139
0.037182
0.039139
0.029354
0.023483
0.003914
0.001957
0.001957
0
0.041096
0.033268
0.046967
0.019569
0.027397
0.009785
0.027397
0.023483
0.050881
0.043053
1
3,002
T
G
A
A
T
C
T
C
T
T
T
C
T
G
G
C
C
T
T
G
C
T
T
C
T
G
A
G
C
T
C
A
T
T
T
A
G
T
G
C
A
G
A
C
A
A
C
C
T
T
G
C
A
G
C
C
A
C
T
G
A
T
G
A
T
C
0.088063
0.029354
0.056751
0.060665
0.052838
0.011742
0
0.027397
0.058708
0.02544
0.021526
0.033268
0.052838
0.04501
0.050881
0.031311
0.031311
0.02544
0.005871
0
0
0
0.02544
0.021526
0.048924
0.017613
0.02544
0.007828
0.027397
0.013699
0.048924
0.054795
1
3,003
T
T
A
A
G
G
T
C
C
T
G
A
A
T
C
T
C
T
T
T
C
T
G
G
C
C
T
T
G
C
T
T
C
T
G
A
G
C
T
C
A
T
T
T
A
G
T
G
C
A
G
A
C
A
A
C
C
T
T
G
C
A
G
C
C
A
0.084149
0.031311
0.054795
0.060665
0.050881
0.011742
0
0.029354
0.058708
0.02544
0.021526
0.033268
0.050881
0.04501
0.050881
0.031311
0.031311
0.027397
0.007828
0
0
0
0.02544
0.023483
0.050881
0.017613
0.02544
0.007828
0.029354
0.011742
0.046967
0.054795
1
3,004
A
T
C
A
T
G
T
T
T
T
T
G
T
T
G
T
T
T
T
T
A
A
G
G
T
C
C
T
G
A
A
T
C
T
C
T
T
T
C
T
G
G
C
C
T
T
G
C
T
T
C
T
G
A
G
C
T
C
A
T
T
T
A
G
T
T
0.086106
0.031311
0.050881
0.066536
0.050881
0.011742
0.001957
0.029354
0.052838
0.02544
0.021526
0.031311
0.04501
0.04501
0.050881
0.033268
0.031311
0.027397
0.007828
0
0.001957
0
0.023483
0.023483
0.056751
0.015656
0.02544
0.007828
0.029354
0.013699
0.04501
0.056751
1
3,005
T
T
A
T
A
A
T
C
A
T
G
T
T
T
T
T
G
T
T
G
T
T
T
T
T
A
A
G
G
T
C
C
T
G
A
A
T
C
T
C
T
T
T
C
T
G
G
C
C
T
T
G
C
T
T
C
T
G
A
G
C
T
C
A
T
C
0.086106
0.031311
0.050881
0.068493
0.050881
0.011742
0.001957
0.029354
0.052838
0.027397
0.021526
0.031311
0.04501
0.046967
0.048924
0.033268
0.031311
0.02544
0.005871
0
0.001957
0
0.023483
0.02544
0.054795
0.015656
0.02544
0.007828
0.027397
0.013699
0.04501
0.058708
1
3,006
A
T
T
A
T
A
A
T
C
A
T
G
T
T
T
T
T
G
T
T
G
T
T
T
T
T
A
A
G
G
T
C
C
T
G
A
A
T
C
T
C
T
T
T
C
T
G
G
C
C
T
T
G
C
T
T
C
T
G
A
G
C
T
C
A
G
0.086106
0.031311
0.050881
0.066536
0.050881
0.011742
0.001957
0.029354
0.052838
0.029354
0.021526
0.031311
0.04501
0.046967
0.048924
0.033268
0.031311
0.02544
0.005871
0
0.001957
0
0.023483
0.02544
0.054795
0.015656
0.02544
0.007828
0.027397
0.013699
0.04501
0.058708
1
3,007
A
A
A
T
T
A
T
A
A
T
C
A
T
G
T
T
T
T
T
G
T
T
G
T
T
T
T
T
A
A
G
G
T
C
C
T
G
A
A
T
C
T
C
T
T
T
C
T
G
G
C
C
T
T
G
C
T
T
C
T
G
A
G
C
T
A
0.084149
0.031311
0.050881
0.064579
0.050881
0.011742
0.001957
0.029354
0.052838
0.029354
0.021526
0.031311
0.04501
0.046967
0.048924
0.033268
0.031311
0.02544
0.005871
0
0.001957
0
0.02544
0.02544
0.054795
0.015656
0.02544
0.007828
0.027397
0.013699
0.046967
0.058708
1
3,008
G
C
T
C
A
G
A
A
G
C
A
A
G
G
C
C
A
G
A
A
A
G
A
G
A
T
T
C
A
G
G
A
C
C
T
T
A
A
A
A
A
C
A
A
C
A
A
A
A
A
C
A
T
G
A
T
T
A
T
A
A
T
T
T
T
T
0.084149
0.031311
0.050881
0.066536
0.050881
0.011742
0.001957
0.029354
0.052838
0.029354
0.021526
0.031311
0.04501
0.046967
0.048924
0.033268
0.031311
0.02544
0.005871
0
0.001957
0
0.02544
0.02544
0.052838
0.015656
0.02544
0.007828
0.027397
0.013699
0.046967
0.058708
1
3,009
T
G
T
C
T
T
C
A
T
G
A
T
G
G
T
C
A
T
G
G
T
G
A
T
T
G
G
A
A
A
C
C
T
A
G
T
G
G
T
A
T
G
T
A
C
C
C
A
C
T
T
A
A
G
A
T
A
T
G
C
A
T
T
T
T
C
0.076321
0.02544
0.041096
0.037182
0.056751
0.031311
0.007828
0.035225
0.02544
0.021526
0.017613
0.050881
0.027397
0.066536
0.041096
0.048924
0.029354
0.052838
0.015656
0.005871
0.005871
0.007828
0.015656
0.013699
0.019569
0.027397
0.04501
0.019569
0.02544
0.031311
0.043053
0.031311
1
3,010
A
C
T
G
T
C
T
T
C
A
T
G
A
T
G
G
T
C
A
T
G
G
T
G
A
T
T
G
G
A
A
A
C
C
T
A
G
T
G
G
T
A
T
G
T
A
C
C
C
A
C
T
T
A
A
G
A
T
A
T
G
C
A
T
T
A
0.076321
0.02544
0.041096
0.037182
0.056751
0.031311
0.009785
0.035225
0.02544
0.021526
0.017613
0.048924
0.027397
0.066536
0.041096
0.048924
0.029354
0.052838
0.015656
0.005871
0.007828
0.007828
0.015656
0.013699
0.019569
0.027397
0.04501
0.019569
0.02544
0.031311
0.041096
0.031311
1
3,011
A
T
G
C
A
T
A
T
C
T
T
A
A
G
T
G
G
G
T
A
C
A
T
A
C
C
A
C
T
A
G
G
T
T
T
C
C
A
A
T
C
A
C
C
A
T
G
A
C
C
A
T
C
A
T
G
A
A
G
A
C
A
G
T
A
C
0.074364
0.02544
0.041096
0.037182
0.056751
0.031311
0.009785
0.035225
0.02544
0.021526
0.017613
0.048924
0.027397
0.066536
0.041096
0.048924
0.029354
0.052838
0.015656
0.005871
0.007828
0.007828
0.015656
0.015656
0.019569
0.027397
0.04501
0.019569
0.02544
0.031311
0.041096
0.031311
1
3,012
C
A
T
A
T
C
T
T
A
A
G
T
G
G
G
T
A
C
A
T
A
C
C
A
C
T
A
G
G
T
T
T
C
C
A
A
T
C
A
C
C
A
T
G
A
C
C
A
T
C
A
T
G
A
A
G
A
C
A
G
T
A
A
G
G
T
0.068493
0.02544
0.041096
0.037182
0.056751
0.033268
0.009785
0.035225
0.02544
0.021526
0.019569
0.048924
0.027397
0.066536
0.041096
0.048924
0.029354
0.052838
0.017613
0.005871
0.007828
0.007828
0.015656
0.015656
0.019569
0.027397
0.04501
0.019569
0.02544
0.031311
0.041096
0.031311
1
3,013
A
T
A
T
C
T
T
A
A
G
T
G
G
G
T
A
C
A
T
A
C
C
A
C
T
A
G
G
T
T
T
C
C
A
A
T
C
A
C
C
A
T
G
A
C
C
A
T
C
A
T
G
A
A
G
A
C
A
G
T
A
A
G
G
C
T
0.068493
0.027397
0.041096
0.035225
0.056751
0.033268
0.009785
0.035225
0.02544
0.021526
0.019569
0.048924
0.027397
0.066536
0.041096
0.048924
0.029354
0.052838
0.017613
0.005871
0.007828
0.007828
0.015656
0.015656
0.019569
0.027397
0.04501
0.019569
0.02544
0.031311
0.041096
0.031311
1
3,014
T
A
A
G
T
G
G
G
T
A
C
A
T
A
C
C
A
C
T
A
G
G
T
T
T
C
C
A
A
T
C
A
C
C
A
T
G
A
C
C
A
T
C
A
T
G
A
A
G
A
C
A
G
T
A
A
G
G
C
A
C
A
T
G
G
T
0.072407
0.027397
0.041096
0.039139
0.056751
0.033268
0.009785
0.035225
0.02544
0.021526
0.017613
0.048924
0.027397
0.064579
0.041096
0.048924
0.027397
0.052838
0.015656
0.005871
0.007828
0.007828
0.015656
0.015656
0.019569
0.027397
0.041096
0.019569
0.02544
0.031311
0.04501
0.031311
1
3,015
A
A
G
T
G
G
G
T
A
C
A
T
A
C
C
A
C
T
A
G
G
T
T
T
C
C
A
A
T
C
A
C
C
A
T
G
A
C
C
A
T
C
A
T
G
A
A
G
A
C
A
G
T
A
A
G
G
C
A
C
A
T
G
G
C
G
0.072407
0.027397
0.041096
0.039139
0.056751
0.033268
0.009785
0.035225
0.02544
0.021526
0.017613
0.048924
0.027397
0.064579
0.041096
0.048924
0.027397
0.052838
0.013699
0.005871
0.007828
0.007828
0.015656
0.015656
0.021526
0.027397
0.041096
0.019569
0.02544
0.031311
0.04501
0.031311
1
3,016
A
A
G
T
G
G
G
T
A
C
A
T
A
C
C
A
C
T
A
G
G
T
T
T
C
C
A
A
T
C
A
C
C
A
T
G
A
C
C
A
T
C
A
T
G
A
A
G
A
C
A
G
T
A
A
G
G
C
A
C
A
T
G
G
C
T
0.072407
0.027397
0.041096
0.039139
0.056751
0.033268
0.009785
0.035225
0.02544
0.021526
0.017613
0.048924
0.027397
0.064579
0.041096
0.048924
0.027397
0.052838
0.013699
0.005871
0.007828
0.007828
0.015656
0.015656
0.021526
0.027397
0.041096
0.019569
0.02544
0.031311
0.04501
0.031311
1
3,017
T
G
G
T
C
A
A
G
C
C
A
T
G
T
G
C
C
T
T
A
C
T
G
T
C
T
T
C
A
T
G
A
T
G
G
T
C
A
T
G
G
T
G
A
T
T
G
G
A
A
A
C
C
T
A
G
T
G
G
T
A
T
G
T
A
G
0.072407
0.027397
0.041096
0.039139
0.056751
0.033268
0.009785
0.033268
0.027397
0.021526
0.017613
0.048924
0.027397
0.064579
0.041096
0.046967
0.027397
0.054795
0.015656
0.005871
0.007828
0.007828
0.015656
0.017613
0.021526
0.027397
0.037182
0.017613
0.027397
0.031311
0.04501
0.031311
1
3,018
C
A
A
T
C
A
C
C
A
T
G
A
C
C
A
T
C
A
T
G
A
A
G
A
C
A
G
T
A
A
G
G
C
A
C
A
T
G
G
C
T
T
G
A
C
C
A
G
C
A
A
C
C
T
C
C
A
T
A
C
A
G
T
C
C
A
0.072407
0.023483
0.041096
0.041096
0.050881
0.033268
0.011742
0.033268
0.027397
0.019569
0.017613
0.043053
0.029354
0.064579
0.039139
0.046967
0.02544
0.056751
0.021526
0.009785
0.009785
0.007828
0.013699
0.017613
0.023483
0.027397
0.037182
0.021526
0.029354
0.031311
0.041096
0.031311
1
3,019
C
A
A
T
C
A
C
C
A
T
G
A
C
C
A
T
C
A
T
G
A
A
G
A
C
A
G
T
A
A
G
G
C
A
C
A
T
G
G
C
T
T
G
A
C
C
A
G
C
A
A
C
C
T
C
C
A
T
A
C
A
G
T
C
C
T
0.072407
0.023483
0.041096
0.041096
0.050881
0.033268
0.011742
0.033268
0.027397
0.019569
0.017613
0.043053
0.029354
0.064579
0.039139
0.046967
0.02544
0.056751
0.021526
0.009785
0.009785
0.007828
0.013699
0.017613
0.023483
0.027397
0.037182
0.021526
0.029354
0.031311
0.041096
0.031311
1
3,020
T
G
G
G
G
A
G
T
G
G
A
T
A
G
A
G
A
C
C
A
T
G
T
G
G
G
A
C
T
G
T
A
T
G
G
A
G
G
T
T
G
C
T
G
G
T
C
A
A
G
C
C
A
T
G
T
G
C
C
T
T
A
C
T
G
G
0.074364
0.02544
0.039139
0.041096
0.050881
0.031311
0.015656
0.031311
0.029354
0.021526
0.015656
0.039139
0.029354
0.066536
0.037182
0.04501
0.02544
0.054795
0.021526
0.009785
0.009785
0.007828
0.015656
0.017613
0.023483
0.027397
0.039139
0.021526
0.027397
0.029354
0.04501
0.031311
1
3,021
T
G
G
G
G
A
G
T
G
G
A
T
A
G
A
G
A
C
C
A
T
G
T
G
G
G
A
C
T
G
T
A
T
G
G
A
G
G
T
T
G
C
T
G
G
T
C
A
A
G
C
C
A
T
G
T
G
C
C
T
T
A
C
T
G
C
0.074364
0.02544
0.039139
0.041096
0.050881
0.031311
0.015656
0.031311
0.029354
0.021526
0.015656
0.039139
0.029354
0.066536
0.037182
0.04501
0.02544
0.054795
0.021526
0.009785
0.009785
0.007828
0.015656
0.017613
0.023483
0.027397
0.039139
0.021526
0.027397
0.029354
0.04501
0.031311
1
3,022
T
A
A
G
G
C
A
C
A
T
G
G
C
T
T
G
A
C
C
A
G
C
A
A
C
C
T
C
C
A
T
A
C
A
G
T
C
C
C
A
C
A
T
G
G
T
C
T
C
T
A
T
C
C
A
C
T
C
C
C
C
A
C
A
C
T
0.074364
0.027397
0.039139
0.041096
0.050881
0.031311
0.015656
0.031311
0.029354
0.021526
0.015656
0.039139
0.029354
0.066536
0.039139
0.04501
0.02544
0.054795
0.021526
0.009785
0.009785
0.007828
0.015656
0.017613
0.023483
0.02544
0.039139
0.021526
0.02544
0.029354
0.04501
0.031311
1
3,023
T
G
T
G
T
G
G
G
G
A
G
T
G
G
A
T
A
G
A
G
A
C
C
A
T
G
T
G
G
G
A
C
T
G
T
A
T
G
G
A
G
G
T
T
G
C
T
G
G
T
C
A
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C
C
A
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G
T
G
C
C
T
T
G
0.074364
0.027397
0.039139
0.041096
0.050881
0.031311
0.015656
0.029354
0.029354
0.021526
0.015656
0.039139
0.029354
0.066536
0.039139
0.04501
0.02544
0.054795
0.021526
0.009785
0.009785
0.007828
0.015656
0.017613
0.023483
0.02544
0.039139
0.023483
0.02544
0.029354
0.04501
0.031311
1
3,024
T
G
A
C
C
A
G
C
A
A
C
C
T
C
C
A
T
A
C
A
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C
C
A
C
A
C
A
G
C
A
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C
G
G
A
A
C
A
C
G
0.072407
0.02544
0.039139
0.041096
0.050881
0.029354
0.015656
0.029354
0.031311
0.021526
0.015656
0.037182
0.031311
0.066536
0.041096
0.04501
0.02544
0.056751
0.021526
0.009785
0.009785
0.007828
0.015656
0.017613
0.023483
0.02544
0.041096
0.027397
0.02544
0.029354
0.039139
0.031311
1
3,025
A
C
C
A
G
C
A
A
C
C
T
C
C
A
T
A
C
A
G
T
C
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A
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A
G
C
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G
A
A
C
A
C
A
A
T
0.072407
0.027397
0.039139
0.039139
0.050881
0.029354
0.015656
0.029354
0.031311
0.021526
0.015656
0.037182
0.029354
0.066536
0.043053
0.04501
0.02544
0.056751
0.021526
0.009785
0.009785
0.007828
0.015656
0.017613
0.023483
0.02544
0.041096
0.027397
0.02544
0.029354
0.039139
0.031311
1
3,026
G
C
A
A
C
C
T
C
C
A
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T
C
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C
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A
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A
A
T
C
A
G
G
0.072407
0.027397
0.041096
0.039139
0.050881
0.029354
0.015656
0.031311
0.031311
0.021526
0.015656
0.035225
0.029354
0.064579
0.04501
0.04501
0.02544
0.056751
0.021526
0.009785
0.009785
0.007828
0.013699
0.017613
0.023483
0.02544
0.041096
0.027397
0.02544
0.029354
0.039139
0.031311
1
3,027
T
C
C
T
G
A
T
T
G
T
G
T
T
C
C
G
C
G
T
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G
T
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G
G
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T
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A
T
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G
A
G
G
T
T
G
0.074364
0.02544
0.041096
0.039139
0.050881
0.029354
0.015656
0.029354
0.031311
0.021526
0.015656
0.035225
0.029354
0.064579
0.04501
0.04501
0.02544
0.056751
0.021526
0.009785
0.009785
0.007828
0.013699
0.017613
0.02544
0.02544
0.041096
0.027397
0.02544
0.029354
0.039139
0.031311
1
3,028
T
C
C
T
G
A
T
T
G
T
G
T
T
C
C
G
C
G
T
G
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G
T
G
G
G
A
C
T
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T
G
G
A
G
G
T
T
A
0.074364
0.02544
0.041096
0.039139
0.050881
0.029354
0.015656
0.029354
0.031311
0.021526
0.015656
0.035225
0.029354
0.064579
0.04501
0.04501
0.02544
0.056751
0.021526
0.009785
0.009785
0.007828
0.013699
0.017613
0.02544
0.02544
0.041096
0.027397
0.02544
0.029354
0.039139
0.031311
1
3,029
C
C
A
T
A
C
A
G
T
C
C
C
A
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A
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G
G
T
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G
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A
C
A
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A
A
T
C
A
G
G
A
A
G
G
A
G
T
0.072407
0.02544
0.041096
0.039139
0.048924
0.029354
0.015656
0.031311
0.031311
0.021526
0.015656
0.035225
0.029354
0.064579
0.043053
0.04501
0.02544
0.056751
0.021526
0.009785
0.011742
0.007828
0.013699
0.019569
0.02544
0.02544
0.041096
0.027397
0.02544
0.029354
0.039139
0.031311
1
3,030
T
A
C
A
G
T
C
C
C
A
C
A
T
G
G
T
C
T
C
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A
C
A
C
A
A
T
C
A
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A
A
G
G
A
G
T
G
G
A
0.068493
0.02544
0.041096
0.039139
0.048924
0.029354
0.015656
0.031311
0.031311
0.021526
0.015656
0.035225
0.029354
0.064579
0.043053
0.04501
0.027397
0.056751
0.021526
0.009785
0.011742
0.009785
0.013699
0.019569
0.023483
0.02544
0.043053
0.027397
0.02544
0.029354
0.039139
0.031311
1
3,031
T
A
C
A
G
T
C
C
C
A
C
A
T
G
G
T
C
T
C
T
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A
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C
A
A
T
C
A
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A
A
G
G
A
G
T
G
G
G
0.068493
0.02544
0.041096
0.039139
0.048924
0.029354
0.015656
0.031311
0.031311
0.021526
0.015656
0.035225
0.029354
0.064579
0.043053
0.04501
0.027397
0.056751
0.021526
0.009785
0.011742
0.009785
0.013699
0.019569
0.023483
0.02544
0.043053
0.027397
0.02544
0.029354
0.039139
0.031311
1
3,032
T
A
C
A
G
T
C
C
C
A
C
A
T
G
G
T
C
T
C
T
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A
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A
A
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C
A
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A
G
G
A
G
T
G
G
T
0.068493
0.02544
0.041096
0.039139
0.048924
0.029354
0.015656
0.031311
0.031311
0.021526
0.015656
0.035225
0.029354
0.064579
0.043053
0.04501
0.027397
0.056751
0.021526
0.009785
0.011742
0.009785
0.013699
0.019569
0.023483
0.02544
0.043053
0.027397
0.02544
0.029354
0.039139
0.031311
1
3,033
A
C
A
T
G
G
T
C
T
C
T
A
T
C
C
A
C
T
C
C
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C
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G
G
A
A
G
G
A
G
T
G
G
A
A
G
A
A
G
T
C
A
G
0.066536
0.02544
0.039139
0.041096
0.046967
0.029354
0.015656
0.031311
0.029354
0.02544
0.015656
0.035225
0.029354
0.064579
0.041096
0.04501
0.029354
0.058708
0.021526
0.009785
0.011742
0.009785
0.013699
0.019569
0.02544
0.023483
0.043053
0.027397
0.027397
0.029354
0.039139
0.029354
1
3,034
A
T
G
A
C
T
T
C
T
T
C
C
A
C
T
C
C
T
T
C
C
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A
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G
G
G
A
G
T
G
G
A
T
A
G
A
G
A
C
C
A
T
G
T
0.066536
0.02544
0.039139
0.041096
0.046967
0.029354
0.015656
0.031311
0.029354
0.02544
0.015656
0.035225
0.029354
0.066536
0.039139
0.04501
0.029354
0.058708
0.021526
0.009785
0.011742
0.009785
0.013699
0.019569
0.02544
0.023483
0.043053
0.027397
0.027397
0.029354
0.039139
0.029354
1
3,035
C
A
T
G
A
A
T
G
A
C
T
T
C
T
T
C
C
A
C
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G
T
G
T
G
G
G
G
A
G
T
G
G
A
T
A
G
A
G
A
C
0.064579
0.023483
0.041096
0.041096
0.04501
0.029354
0.015656
0.031311
0.031311
0.02544
0.015656
0.035225
0.029354
0.066536
0.039139
0.04501
0.027397
0.058708
0.021526
0.009785
0.011742
0.009785
0.013699
0.019569
0.027397
0.023483
0.043053
0.027397
0.027397
0.029354
0.039139
0.031311
1
3,036
C
T
C
C
C
A
C
G
C
T
G
G
C
A
C
A
T
G
A
A
T
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G
T
G
T
T
C
C
G
C
G
T
G
C
T
G
T
G
T
G
G
A
0.064579
0.023483
0.041096
0.041096
0.04501
0.027397
0.015656
0.029354
0.031311
0.02544
0.015656
0.046967
0.031311
0.064579
0.041096
0.043053
0.027397
0.056751
0.021526
0.009785
0.011742
0.009785
0.013699
0.019569
0.027397
0.021526
0.043053
0.027397
0.027397
0.029354
0.037182
0.029354
1
3,037
C
G
C
G
G
A
A
C
A
C
A
A
T
C
A
G
G
A
A
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C
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A
G
C
G
T
G
G
G
A
G
T
T
G
A
C
A
A
T
C
A
G
0.058708
0.023483
0.041096
0.043053
0.046967
0.027397
0.015656
0.027397
0.031311
0.02544
0.015656
0.04501
0.033268
0.066536
0.041096
0.043053
0.027397
0.056751
0.021526
0.009785
0.011742
0.009785
0.013699
0.017613
0.029354
0.021526
0.043053
0.027397
0.027397
0.029354
0.037182
0.031311
1
3,038
G
C
G
G
A
A
C
A
C
A
A
T
C
A
G
G
A
A
G
G
A
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G
C
G
T
G
G
G
A
G
T
T
G
A
C
A
A
T
C
A
C
A
0.056751
0.023483
0.041096
0.043053
0.046967
0.027397
0.015656
0.027397
0.031311
0.02544
0.015656
0.04501
0.033268
0.066536
0.041096
0.043053
0.027397
0.056751
0.021526
0.009785
0.011742
0.009785
0.013699
0.017613
0.029354
0.021526
0.043053
0.027397
0.027397
0.029354
0.039139
0.031311
1
3,039
A
A
C
A
C
A
A
T
C
A
G
G
A
A
G
G
A
G
T
G
G
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G
G
G
A
G
T
T
G
A
C
A
A
T
C
A
C
T
G
G
C
T
0.054795
0.023483
0.043053
0.043053
0.046967
0.027397
0.015656
0.027397
0.031311
0.02544
0.015656
0.04501
0.033268
0.066536
0.041096
0.043053
0.027397
0.056751
0.021526
0.009785
0.011742
0.009785
0.013699
0.017613
0.029354
0.021526
0.043053
0.027397
0.027397
0.029354
0.039139
0.031311
1
3,040
C
A
C
A
A
T
C
A
G
G
A
A
G
G
A
G
T
G
G
A
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G
A
G
T
T
G
A
C
A
A
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C
A
C
T
G
G
C
G
A
C
0.054795
0.023483
0.043053
0.041096
0.046967
0.027397
0.015656
0.027397
0.031311
0.027397
0.015656
0.043053
0.033268
0.066536
0.041096
0.043053
0.027397
0.056751
0.021526
0.009785
0.011742
0.009785
0.013699
0.017613
0.029354
0.021526
0.04501
0.027397
0.027397
0.029354
0.039139
0.031311
1
3,041
G
G
A
A
G
G
A
G
T
G
G
A
A
G
A
A
G
T
C
A
T
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A
A
T
C
A
C
T
G
G
C
G
A
T
C
T
T
G
C
A
G
T
0.052838
0.023483
0.041096
0.043053
0.046967
0.027397
0.015656
0.02544
0.031311
0.027397
0.015656
0.048924
0.033268
0.068493
0.041096
0.043053
0.027397
0.056751
0.021526
0.009785
0.011742
0.009785
0.013699
0.017613
0.029354
0.021526
0.04501
0.027397
0.027397
0.027397
0.037182
0.031311
1
3,042
A
G
A
A
G
T
C
A
T
T
C
A
T
G
T
G
C
C
A
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C
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G
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A
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T
C
T
T
G
C
A
G
A
C
A
C
A
A
T
C
T
T
T
G
A
0.050881
0.021526
0.041096
0.04501
0.046967
0.02544
0.015656
0.023483
0.031311
0.031311
0.013699
0.052838
0.033268
0.068493
0.043053
0.043053
0.027397
0.056751
0.019569
0.009785
0.011742
0.009785
0.011742
0.019569
0.029354
0.021526
0.04501
0.027397
0.027397
0.027397
0.035225
0.033268
1
3,043
A
C
A
A
A
G
A
T
T
G
T
G
T
C
T
G
C
A
A
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T
C
A
A
C
T
C
C
C
A
C
G
C
T
G
G
C
A
C
A
T
G
A
A
T
G
A
C
T
T
C
C
0.050881
0.021526
0.041096
0.04501
0.046967
0.027397
0.015656
0.023483
0.031311
0.031311
0.013699
0.052838
0.033268
0.068493
0.043053
0.043053
0.027397
0.056751
0.019569
0.009785
0.011742
0.009785
0.011742
0.019569
0.029354
0.021526
0.04501
0.027397
0.027397
0.02544
0.035225
0.033268
1
3,044
A
G
A
C
A
C
A
A
T
C
T
T
T
G
T
A
G
C
T
T
T
T
A
C
C
A
A
A
G
A
G
C
T
G
C
A
T
G
C
C
G
A
C
C
A
C
G
G
C
A
A
A
A
A
T
G
A
A
G
A
C
G
A
T
G
A
0.052838
0.017613
0.043053
0.054795
0.033268
0.027397
0.015656
0.021526
0.041096
0.029354
0.015656
0.052838
0.041096
0.054795
0.04501
0.035225
0.027397
0.054795
0.021526
0.009785
0.011742
0.009785
0.017613
0.019569
0.035225
0.023483
0.035225
0.027397
0.027397
0.021526
0.037182
0.039139
1
3,045
T
C
A
T
C
G
T
C
T
T
C
A
T
T
T
T
T
G
C
C
G
T
G
G
T
C
G
G
C
A
T
G
C
A
G
C
T
C
T
T
T
G
G
T
A
A
A
A
G
C
T
A
C
A
A
A
G
A
T
T
G
T
G
T
C
A
0.052838
0.019569
0.043053
0.054795
0.033268
0.02544
0.015656
0.021526
0.041096
0.029354
0.015656
0.052838
0.041096
0.054795
0.04501
0.035225
0.027397
0.054795
0.021526
0.009785
0.011742
0.009785
0.017613
0.019569
0.035225
0.023483
0.035225
0.027397
0.027397
0.021526
0.037182
0.039139
1
3,046
G
C
T
T
T
T
A
C
C
A
A
A
G
A
G
C
T
G
C
A
T
G
C
C
G
A
C
C
A
C
G
G
C
A
A
A
A
A
T
G
A
A
G
A
C
G
A
T
G
A
T
G
G
C
C
A
A
G
A
C
G
A
G
G
G
T
0.046967
0.019569
0.043053
0.050881
0.031311
0.027397
0.017613
0.021526
0.043053
0.031311
0.017613
0.050881
0.041096
0.056751
0.043053
0.033268
0.029354
0.052838
0.021526
0.011742
0.011742
0.009785
0.017613
0.023483
0.033268
0.02544
0.033268
0.029354
0.02544
0.019569
0.037182
0.043053
1