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int64
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
2,847
A
T
A
T
C
C
T
T
C
C
T
G
G
T
T
G
T
G
G
T
G
A
A
C
A
T
G
T
A
C
A
T
C
G
C
G
G
T
C
A
T
C
C
T
G
G
A
G
A
A
C
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T
T
G
C
T
A
C
G
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0.058708
1
2,848
T
C
A
T
C
A
T
A
T
C
C
T
T
C
C
T
G
G
T
T
G
T
G
G
T
G
A
A
C
A
T
G
T
A
C
A
T
C
G
C
G
G
T
C
A
T
C
C
T
G
G
A
G
A
A
C
T
T
C
A
G
T
G
T
T
C
0.043053
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1
2,849
C
A
T
C
A
T
C
A
T
A
T
C
C
T
T
C
C
T
G
G
T
T
G
T
G
G
T
G
A
A
C
A
T
G
T
A
C
A
T
C
G
C
G
G
T
C
A
T
C
C
T
G
G
A
G
A
A
C
T
T
C
A
G
T
G
C
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0.023483
0.056751
1
2,850
A
A
T
T
T
T
C
T
T
T
T
T
T
G
T
C
A
G
T
T
A
C
A
T
C
A
T
C
A
T
A
T
C
C
T
T
C
C
T
G
G
T
T
G
T
G
G
T
G
A
A
C
A
T
G
T
A
C
A
T
C
G
C
G
G
T
0.04501
0.054795
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0
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0.054795
1
2,851
A
A
T
T
T
T
C
T
T
T
T
T
T
G
T
C
A
G
T
T
A
C
A
T
C
A
T
C
A
T
A
T
C
C
T
T
C
C
T
G
G
T
T
G
T
G
G
T
G
A
A
C
A
T
G
T
A
C
A
T
C
G
C
G
G
A
0.04501
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0.011742
0.023483
0.054795
1
2,852
T
G
T
T
G
G
A
A
T
T
T
T
C
T
T
T
T
T
T
G
T
C
A
G
T
T
A
C
A
T
C
A
T
C
A
T
A
T
C
C
T
T
C
C
T
G
G
T
T
G
T
G
G
T
G
A
A
C
A
T
G
T
A
C
A
G
0.046967
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0.017613
0.035225
0.019569
0.041096
0.011742
0.023483
0.052838
1
2,853
T
C
A
C
C
A
C
A
A
C
C
A
G
G
A
A
G
G
A
T
A
T
G
A
T
G
A
T
G
T
A
A
C
T
G
A
C
A
A
A
A
A
A
G
A
A
A
A
T
T
C
C
A
A
C
A
G
A
T
G
G
G
T
T
C
T
0.04501
0.054795
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0.039139
0.017613
0.033268
0.019569
0.041096
0.013699
0.023483
0.052838
1
2,854
C
A
C
C
A
C
A
A
C
C
A
G
G
A
A
G
G
A
T
A
T
G
A
T
G
A
T
G
T
A
A
C
T
G
A
C
A
A
A
A
A
A
G
A
A
A
A
T
T
C
C
A
A
C
A
G
A
T
G
G
G
T
T
C
C
C
0.04501
0.054795
0.035225
0.027397
0.039139
0.02544
0.001957
0.039139
0.039139
0.029354
0.029354
0.013699
0.04501
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0.019569
0.046967
0.048924
0.02544
0.007828
0.009785
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0.039139
0.017613
0.033268
0.019569
0.041096
0.013699
0.023483
0.052838
1
2,855
T
G
G
G
A
A
C
C
C
A
T
C
T
G
T
T
G
G
A
A
T
T
T
T
C
T
T
T
T
T
T
G
T
C
A
G
T
T
A
C
A
T
C
A
T
C
A
T
A
T
C
C
T
T
C
C
T
G
G
T
T
G
T
G
G
A
0.04501
0.054795
0.035225
0.027397
0.039139
0.02544
0.001957
0.039139
0.039139
0.029354
0.029354
0.013699
0.04501
0.054795
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0.019569
0.046967
0.046967
0.02544
0.007828
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0.011742
0.015656
0.039139
0.041096
0.017613
0.033268
0.019569
0.039139
0.013699
0.023483
0.054795
1
2,856
A
G
A
C
T
G
T
G
G
G
A
A
C
C
C
A
T
C
T
G
T
T
G
G
A
A
T
T
T
T
C
T
T
T
T
T
T
G
T
C
A
G
T
T
A
C
A
T
C
A
T
C
A
T
A
T
C
C
T
T
C
C
T
G
G
C
0.04501
0.056751
0.035225
0.027397
0.041096
0.02544
0.001957
0.039139
0.039139
0.029354
0.029354
0.013699
0.04501
0.054795
0.052838
0.019569
0.046967
0.04501
0.02544
0.007828
0.009785
0.011742
0.015656
0.039139
0.041096
0.019569
0.031311
0.017613
0.039139
0.013699
0.023483
0.056751
1
2,857
A
T
A
T
G
A
T
G
A
T
G
T
A
A
C
T
G
A
C
A
A
A
A
A
A
G
A
A
A
A
T
T
C
C
A
A
C
A
G
A
T
G
G
G
T
T
C
C
C
A
C
A
G
T
C
T
C
C
C
T
T
A
A
C
T
T
0.04501
0.056751
0.037182
0.02544
0.041096
0.02544
0.001957
0.041096
0.041096
0.02544
0.031311
0.013699
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0.052838
0.019569
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0.043053
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0.007828
0.009785
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0.039139
0.043053
0.019569
0.031311
0.017613
0.039139
0.013699
0.023483
0.054795
1
2,858
G
A
C
A
A
A
A
A
A
G
A
A
A
A
T
T
C
C
A
A
C
A
G
A
T
G
G
G
T
T
C
C
C
A
C
A
G
T
C
T
C
C
C
T
T
A
A
C
T
G
A
G
C
T
T
C
C
A
G
G
G
T
T
A
A
G
0.041096
0.052838
0.037182
0.02544
0.039139
0.023483
0.001957
0.041096
0.041096
0.02544
0.035225
0.013699
0.046967
0.054795
0.046967
0.017613
0.04501
0.039139
0.02544
0.009785
0.011742
0.011742
0.021526
0.039139
0.043053
0.019569
0.031311
0.021526
0.041096
0.015656
0.02544
0.054795
1
2,859
G
A
C
A
A
A
A
A
A
G
A
A
A
A
T
T
C
C
A
A
C
A
G
A
T
G
G
G
T
T
C
C
C
A
C
A
G
T
C
T
C
C
C
T
T
A
A
C
T
G
A
G
C
T
T
C
C
A
G
G
G
T
T
A
A
T
0.041096
0.052838
0.037182
0.02544
0.039139
0.023483
0.001957
0.041096
0.041096
0.02544
0.035225
0.013699
0.046967
0.054795
0.046967
0.017613
0.04501
0.039139
0.02544
0.009785
0.011742
0.011742
0.021526
0.039139
0.043053
0.019569
0.031311
0.021526
0.041096
0.015656
0.02544
0.054795
1
2,860
C
A
A
A
A
A
A
G
A
A
A
A
T
T
C
C
A
A
C
A
G
A
T
G
G
G
T
T
C
C
C
A
C
A
G
T
C
T
C
C
C
T
T
A
A
C
T
G
A
G
C
T
T
C
C
A
G
G
G
T
T
A
A
C
T
T
0.043053
0.052838
0.037182
0.02544
0.039139
0.023483
0.001957
0.041096
0.041096
0.02544
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0.043053
0.019569
0.029354
0.019569
0.041096
0.015656
0.027397
0.054795
1
2,861
A
A
A
A
G
A
A
A
A
T
T
C
C
A
A
C
A
G
A
T
G
G
G
T
T
C
C
C
A
C
A
G
T
C
T
C
C
C
T
T
A
A
C
T
G
A
G
C
T
T
C
C
A
G
G
G
T
T
A
A
C
T
T
T
A
C
0.043053
0.054795
0.037182
0.02544
0.041096
0.023483
0.001957
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0.039139
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0.043053
0.019569
0.029354
0.019569
0.041096
0.015656
0.027397
0.054795
1
2,862
A
A
A
G
A
A
A
A
T
T
C
C
A
A
C
A
G
A
T
G
G
G
T
T
C
C
C
A
C
A
G
T
C
T
C
C
C
T
T
A
A
C
T
G
A
G
C
T
T
C
C
A
G
G
G
T
T
A
A
C
T
T
T
A
T
A
0.043053
0.056751
0.037182
0.023483
0.041096
0.023483
0.001957
0.041096
0.039139
0.02544
0.035225
0.013699
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0.048924
0.017613
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0.009785
0.011742
0.011742
0.021526
0.039139
0.043053
0.019569
0.029354
0.019569
0.041096
0.015656
0.027397
0.054795
1
2,863
C
T
G
A
G
C
T
T
C
C
A
G
G
G
T
T
A
A
C
T
T
T
A
T
T
A
G
G
G
T
C
A
C
A
G
T
C
G
G
G
T
G
G
C
T
T
A
C
T
G
T
T
G
A
G
A
A
T
G
G
G
T
G
C
T
G
0.039139
0.052838
0.041096
0.019569
0.043053
0.021526
0.005871
0.039139
0.037182
0.02544
0.037182
0.011742
0.048924
0.058708
0.046967
0.019569
0.041096
0.039139
0.027397
0.009785
0.011742
0.011742
0.021526
0.035225
0.043053
0.021526
0.031311
0.017613
0.046967
0.015656
0.02544
0.052838
1
2,864
A
A
C
C
T
C
T
G
C
T
G
G
C
T
G
G
G
A
T
G
G
A
T
T
G
C
T
A
G
C
A
C
C
C
A
T
T
C
T
C
A
A
C
A
G
T
A
A
G
C
C
A
C
C
C
G
A
C
T
G
T
G
A
C
C
T
0.041096
0.048924
0.04501
0.015656
0.043053
0.021526
0.009785
0.035225
0.039139
0.027397
0.041096
0.011742
0.052838
0.052838
0.046967
0.019569
0.041096
0.037182
0.031311
0.007828
0.009785
0.011742
0.023483
0.035225
0.037182
0.023483
0.029354
0.017613
0.048924
0.017613
0.02544
0.050881
1
2,865
G
T
G
G
C
T
T
A
C
T
G
T
T
G
A
G
A
A
T
G
G
G
T
G
C
T
A
G
C
A
A
T
C
C
A
T
C
C
C
A
G
C
C
A
G
C
A
G
A
G
G
T
T
G
T
A
A
T
T
T
G
G
A
A
T
T
0.039139
0.046967
0.043053
0.019569
0.043053
0.021526
0.009785
0.033268
0.037182
0.027397
0.043053
0.011742
0.050881
0.052838
0.046967
0.019569
0.041096
0.039139
0.029354
0.009785
0.011742
0.011742
0.023483
0.035225
0.037182
0.023483
0.029354
0.021526
0.048924
0.017613
0.02544
0.048924
1
2,866
T
G
G
C
T
T
A
C
T
G
T
T
G
A
G
A
A
T
G
G
G
T
G
C
T
A
G
C
A
A
T
C
C
A
T
C
C
C
A
G
C
C
A
G
C
A
G
A
G
G
T
T
G
T
A
A
T
T
T
G
G
A
A
T
A
G
0.039139
0.046967
0.043053
0.019569
0.043053
0.021526
0.009785
0.033268
0.037182
0.027397
0.043053
0.011742
0.052838
0.052838
0.046967
0.019569
0.041096
0.039139
0.029354
0.009785
0.011742
0.011742
0.023483
0.033268
0.037182
0.023483
0.029354
0.021526
0.048924
0.017613
0.02544
0.048924
1
2,867
C
T
T
A
C
T
G
T
T
G
A
G
A
A
T
G
G
G
T
G
C
T
A
G
C
A
A
T
C
C
A
T
C
C
C
A
G
C
C
A
G
C
A
G
A
G
G
T
T
G
T
A
A
T
T
T
G
G
A
A
T
A
G
G
C
G
0.039139
0.046967
0.043053
0.019569
0.043053
0.021526
0.009785
0.033268
0.037182
0.027397
0.04501
0.011742
0.052838
0.052838
0.046967
0.019569
0.041096
0.037182
0.027397
0.009785
0.011742
0.011742
0.02544
0.033268
0.037182
0.023483
0.029354
0.021526
0.048924
0.017613
0.02544
0.048924
1
2,868
T
A
C
T
G
T
T
G
A
G
A
A
T
G
G
G
T
G
C
T
A
G
C
A
A
T
C
C
A
T
C
C
C
A
G
C
C
A
G
C
A
G
A
G
G
T
T
G
T
A
A
T
T
T
G
G
A
A
T
A
G
G
C
A
G
G
0.037182
0.046967
0.043053
0.019569
0.043053
0.021526
0.009785
0.033268
0.037182
0.029354
0.04501
0.011742
0.052838
0.052838
0.04501
0.019569
0.041096
0.037182
0.027397
0.009785
0.011742
0.011742
0.027397
0.033268
0.037182
0.023483
0.029354
0.021526
0.048924
0.017613
0.02544
0.048924
1
2,869
C
A
T
G
A
T
C
T
G
C
C
T
A
T
T
C
C
A
A
A
T
T
A
C
A
A
C
C
T
C
T
G
C
T
G
G
C
T
G
G
G
A
T
G
G
A
T
T
G
C
T
A
G
C
A
C
C
C
A
T
T
C
T
C
A
T
0.037182
0.04501
0.04501
0.019569
0.043053
0.019569
0.011742
0.033268
0.039139
0.029354
0.043053
0.011742
0.052838
0.050881
0.046967
0.019569
0.041096
0.037182
0.027397
0.009785
0.011742
0.011742
0.027397
0.031311
0.037182
0.02544
0.031311
0.021526
0.048924
0.017613
0.02544
0.046967
1
2,870
G
A
G
A
A
T
G
G
G
T
G
C
T
A
G
C
A
A
T
C
C
A
T
C
C
C
A
G
C
C
A
G
C
A
G
A
G
G
T
T
G
T
A
A
T
T
T
G
G
A
A
T
A
G
G
C
A
G
A
T
C
A
T
G
C
T
0.037182
0.04501
0.04501
0.019569
0.043053
0.019569
0.011742
0.033268
0.039139
0.029354
0.043053
0.009785
0.052838
0.050881
0.046967
0.019569
0.041096
0.037182
0.027397
0.011742
0.011742
0.011742
0.027397
0.031311
0.037182
0.02544
0.031311
0.021526
0.048924
0.017613
0.02544
0.046967
1
2,871
A
C
A
G
C
A
T
G
A
T
C
T
G
C
C
T
A
T
T
C
C
A
A
A
T
T
A
C
A
A
C
C
T
C
T
G
C
T
G
G
C
T
G
G
G
A
T
G
G
A
T
T
G
C
T
A
G
C
A
C
C
C
A
T
T
C
0.037182
0.04501
0.04501
0.019569
0.043053
0.019569
0.011742
0.033268
0.037182
0.029354
0.043053
0.009785
0.056751
0.050881
0.046967
0.019569
0.041096
0.037182
0.027397
0.011742
0.011742
0.011742
0.02544
0.031311
0.035225
0.02544
0.031311
0.021526
0.050881
0.017613
0.02544
0.046967
1
2,872
T
G
G
C
A
A
C
A
G
C
A
T
G
A
T
C
T
G
C
C
T
A
T
T
C
C
A
A
A
T
T
A
C
A
A
C
C
T
C
T
G
C
T
G
G
C
T
G
G
G
A
T
G
G
A
T
T
G
C
T
A
G
C
A
C
A
0.037182
0.043053
0.04501
0.019569
0.041096
0.019569
0.011742
0.035225
0.035225
0.029354
0.043053
0.009785
0.054795
0.048924
0.046967
0.021526
0.041096
0.037182
0.027397
0.011742
0.013699
0.011742
0.02544
0.033268
0.035225
0.02544
0.031311
0.021526
0.050881
0.017613
0.02544
0.048924
1
2,873
A
G
C
A
A
T
C
C
A
T
C
C
C
A
G
C
C
A
G
C
A
G
A
G
G
T
T
G
T
A
A
T
T
T
G
G
A
A
T
A
G
G
C
A
G
A
T
C
A
T
G
C
T
G
T
T
G
C
C
A
A
A
G
G
T
G
0.035225
0.04501
0.043053
0.019569
0.043053
0.019569
0.011742
0.035225
0.035225
0.029354
0.043053
0.009785
0.054795
0.048924
0.04501
0.021526
0.041096
0.037182
0.027397
0.013699
0.013699
0.011742
0.02544
0.031311
0.037182
0.02544
0.031311
0.021526
0.052838
0.017613
0.02544
0.046967
1
2,874
T
G
A
G
A
C
C
T
T
T
G
G
C
A
A
C
A
G
C
A
T
G
A
T
C
T
G
C
C
T
A
T
T
C
C
A
A
A
T
T
A
C
A
A
C
C
T
C
T
G
C
T
G
G
C
T
G
G
G
A
T
G
G
A
T
C
0.035225
0.04501
0.043053
0.019569
0.043053
0.021526
0.011742
0.033268
0.035225
0.029354
0.04501
0.009785
0.054795
0.046967
0.04501
0.021526
0.043053
0.037182
0.029354
0.013699
0.013699
0.011742
0.02544
0.031311
0.037182
0.023483
0.031311
0.021526
0.052838
0.017613
0.02544
0.04501
1
2,875
C
T
T
T
G
A
G
A
C
C
T
T
T
G
G
C
A
A
C
A
G
C
A
T
G
A
T
C
T
G
C
C
T
A
T
T
C
C
A
A
A
T
T
A
C
A
A
C
C
T
C
T
G
C
T
G
G
C
T
G
G
G
A
T
G
G
0.035225
0.04501
0.043053
0.019569
0.043053
0.021526
0.011742
0.033268
0.035225
0.029354
0.04501
0.009785
0.052838
0.046967
0.04501
0.021526
0.043053
0.037182
0.029354
0.013699
0.013699
0.011742
0.027397
0.031311
0.037182
0.023483
0.031311
0.021526
0.050881
0.019569
0.02544
0.04501
1
2,876
T
C
A
A
C
T
T
T
G
A
G
A
C
C
T
T
T
G
G
C
A
A
C
A
G
C
A
T
G
A
T
C
T
G
C
C
T
A
T
T
C
C
A
A
A
T
T
A
C
A
A
C
C
T
C
T
G
C
T
G
G
C
T
G
G
C
0.035225
0.04501
0.043053
0.019569
0.043053
0.021526
0.011742
0.031311
0.035225
0.029354
0.04501
0.009785
0.052838
0.046967
0.04501
0.019569
0.043053
0.037182
0.033268
0.013699
0.013699
0.011742
0.027397
0.029354
0.037182
0.02544
0.031311
0.021526
0.052838
0.019569
0.02544
0.043053
1
2,877
C
A
G
A
G
G
T
T
G
T
A
A
T
T
T
G
G
A
A
T
A
G
G
C
A
G
A
T
C
A
T
G
C
T
G
T
T
G
C
C
A
A
A
G
G
T
C
T
C
A
A
A
G
T
T
G
A
A
C
A
T
G
T
C
A
A
0.037182
0.04501
0.043053
0.021526
0.04501
0.021526
0.013699
0.031311
0.033268
0.027397
0.043053
0.011742
0.052838
0.046967
0.04501
0.021526
0.041096
0.037182
0.033268
0.013699
0.015656
0.011742
0.027397
0.02544
0.039139
0.02544
0.031311
0.019569
0.052838
0.019569
0.02544
0.041096
1
2,878
G
A
G
G
G
A
A
G
T
T
G
G
G
A
T
C
G
A
T
G
A
C
A
T
G
T
T
C
A
A
C
T
T
T
G
A
G
A
C
C
T
T
T
G
G
C
A
A
C
A
G
C
A
T
G
A
T
C
T
G
C
C
T
A
T
C
0.039139
0.04501
0.041096
0.021526
0.04501
0.021526
0.013699
0.029354
0.031311
0.031311
0.043053
0.013699
0.054795
0.046967
0.04501
0.019569
0.039139
0.037182
0.033268
0.015656
0.017613
0.011742
0.027397
0.02544
0.037182
0.02544
0.027397
0.021526
0.052838
0.019569
0.02544
0.041096
1
2,879
T
G
C
T
G
T
T
G
C
C
A
A
A
G
G
T
C
T
C
A
A
A
G
T
T
G
A
A
C
A
T
G
T
C
A
T
C
G
A
T
C
C
C
A
A
C
T
T
C
C
C
T
C
T
T
A
A
C
A
T
A
G
G
C
A
A
0.041096
0.04501
0.041096
0.021526
0.04501
0.023483
0.013699
0.02544
0.033268
0.029354
0.043053
0.015656
0.054795
0.048924
0.04501
0.017613
0.037182
0.037182
0.033268
0.015656
0.017613
0.011742
0.027397
0.02544
0.037182
0.02544
0.027397
0.021526
0.052838
0.021526
0.02544
0.039139
1
2,880
T
T
T
G
C
C
T
A
T
G
T
T
A
A
G
A
G
G
G
A
A
G
T
T
G
G
G
A
T
C
G
A
T
G
A
C
A
T
G
T
T
C
A
A
C
T
T
T
G
A
G
A
C
C
T
T
T
G
G
C
A
A
C
A
G
A
0.041096
0.043053
0.041096
0.021526
0.04501
0.023483
0.013699
0.02544
0.033268
0.029354
0.04501
0.015656
0.054795
0.048924
0.04501
0.017613
0.037182
0.037182
0.033268
0.015656
0.017613
0.011742
0.029354
0.02544
0.035225
0.02544
0.027397
0.021526
0.052838
0.021526
0.02544
0.039139
1
2,881
C
T
T
C
C
C
T
C
T
T
A
A
C
A
T
A
G
G
C
A
A
A
G
T
T
G
G
A
C
A
T
C
C
C
A
A
A
G
A
T
G
G
C
G
T
A
G
A
T
G
A
A
C
A
T
G
A
C
T
A
G
G
A
A
G
A
0.04501
0.043053
0.041096
0.029354
0.039139
0.021526
0.015656
0.027397
0.035225
0.029354
0.039139
0.021526
0.052838
0.048924
0.046967
0.015656
0.035225
0.035225
0.033268
0.013699
0.015656
0.009785
0.029354
0.02544
0.039139
0.023483
0.029354
0.021526
0.046967
0.019569
0.027397
0.043053
1
2,882
C
C
T
C
C
T
A
C
T
C
T
T
C
C
T
A
G
T
C
A
T
G
T
T
C
A
T
C
T
A
C
G
C
C
A
T
C
T
T
T
G
G
G
A
T
G
T
C
C
A
A
C
T
T
T
G
C
C
T
A
T
G
T
T
A
T
0.050881
0.04501
0.041096
0.031311
0.039139
0.021526
0.015656
0.027397
0.035225
0.029354
0.039139
0.019569
0.048924
0.04501
0.046967
0.015656
0.035225
0.035225
0.033268
0.013699
0.015656
0.009785
0.029354
0.02544
0.039139
0.023483
0.029354
0.021526
0.04501
0.019569
0.033268
0.039139
1
2,883
A
A
C
A
T
A
G
G
C
A
A
A
G
T
T
G
G
A
C
A
T
C
C
C
A
A
A
G
A
T
G
G
C
G
T
A
G
A
T
G
A
A
C
A
T
G
A
C
T
A
G
G
A
A
G
A
G
T
A
G
G
A
G
G
C
G
0.050881
0.046967
0.041096
0.031311
0.039139
0.021526
0.015656
0.027397
0.035225
0.029354
0.039139
0.019569
0.046967
0.04501
0.046967
0.015656
0.035225
0.035225
0.033268
0.013699
0.015656
0.009785
0.029354
0.02544
0.039139
0.023483
0.029354
0.021526
0.04501
0.019569
0.033268
0.039139
1
2,884
C
A
T
A
G
G
C
A
A
A
G
T
T
G
G
A
C
A
T
C
C
C
A
A
A
G
A
T
G
G
C
G
T
A
G
A
T
G
A
A
C
A
T
G
A
C
T
A
G
G
A
A
G
A
G
T
A
G
G
A
G
G
C
C
G
C
0.050881
0.046967
0.041096
0.031311
0.039139
0.021526
0.015656
0.027397
0.035225
0.029354
0.039139
0.019569
0.046967
0.04501
0.046967
0.015656
0.035225
0.035225
0.033268
0.013699
0.015656
0.009785
0.029354
0.02544
0.039139
0.023483
0.029354
0.021526
0.04501
0.019569
0.033268
0.039139
1
2,885
C
A
T
C
G
G
C
C
T
C
C
T
A
C
T
C
T
T
C
C
T
A
G
T
C
A
T
G
T
T
C
A
T
C
T
A
C
G
C
C
A
T
C
T
T
T
G
G
G
A
T
G
T
C
C
A
A
C
T
T
T
G
C
C
T
C
0.050881
0.04501
0.041096
0.031311
0.039139
0.021526
0.015656
0.027397
0.035225
0.029354
0.039139
0.023483
0.046967
0.046967
0.046967
0.015656
0.035225
0.035225
0.033268
0.013699
0.015656
0.009785
0.029354
0.02544
0.039139
0.023483
0.029354
0.021526
0.04501
0.017613
0.031311
0.039139
1
2,886
G
T
T
G
T
T
T
A
A
C
A
T
C
G
G
C
C
T
C
C
T
A
C
T
C
T
T
C
C
T
A
G
T
C
A
T
G
T
T
C
A
T
C
T
A
C
G
C
C
A
T
C
T
T
T
G
G
G
A
T
G
T
C
C
A
A
0.046967
0.046967
0.043053
0.031311
0.039139
0.021526
0.015656
0.02544
0.039139
0.029354
0.039139
0.023483
0.046967
0.046967
0.04501
0.015656
0.033268
0.035225
0.033268
0.013699
0.015656
0.009785
0.031311
0.02544
0.043053
0.021526
0.029354
0.021526
0.04501
0.017613
0.031311
0.037182
1
2,887
C
C
C
T
T
C
C
T
G
C
G
T
T
G
T
T
T
A
A
C
A
T
C
G
G
C
C
T
C
C
T
A
C
T
C
T
T
C
C
T
A
G
T
C
A
T
G
T
T
C
A
T
C
T
A
C
G
C
C
A
T
C
T
T
T
T
0.043053
0.046967
0.04501
0.027397
0.039139
0.021526
0.015656
0.02544
0.037182
0.033268
0.039139
0.023483
0.046967
0.046967
0.046967
0.015656
0.033268
0.037182
0.033268
0.013699
0.015656
0.009785
0.031311
0.027397
0.039139
0.021526
0.029354
0.021526
0.04501
0.017613
0.033268
0.037182
1
2,888
G
A
A
C
A
T
G
A
C
T
A
G
G
A
A
G
A
G
T
A
G
G
A
G
G
C
C
G
A
T
G
T
T
A
A
A
C
A
A
C
G
C
A
G
G
A
A
G
G
G
A
C
A
T
C
A
T
C
A
A
A
G
C
A
A
G
0.043053
0.04501
0.046967
0.027397
0.037182
0.023483
0.015656
0.027397
0.037182
0.033268
0.043053
0.023483
0.04501
0.04501
0.04501
0.015656
0.033268
0.033268
0.029354
0.013699
0.015656
0.009785
0.031311
0.029354
0.039139
0.023483
0.029354
0.021526
0.043053
0.019569
0.035225
0.039139
1
2,889
G
C
T
G
C
T
C
T
T
T
G
C
T
T
T
G
A
T
G
A
T
G
T
C
C
C
T
T
C
C
T
G
C
G
T
T
G
T
T
T
A
A
C
A
T
C
G
G
C
C
T
C
C
T
A
C
T
C
T
T
C
C
T
A
G
A
0.043053
0.046967
0.046967
0.027397
0.035225
0.02544
0.015656
0.02544
0.035225
0.033268
0.04501
0.023483
0.04501
0.04501
0.04501
0.013699
0.033268
0.031311
0.031311
0.013699
0.015656
0.009785
0.031311
0.027397
0.041096
0.021526
0.029354
0.021526
0.04501
0.019569
0.035225
0.041096
1
2,890
T
A
G
G
A
A
G
A
G
T
A
G
G
A
G
G
C
C
G
A
T
G
T
T
A
A
A
C
A
A
C
G
C
A
G
G
A
A
G
G
G
A
C
A
T
C
A
T
C
A
A
A
G
C
A
A
A
G
A
G
C
A
G
C
G
T
0.043053
0.046967
0.046967
0.027397
0.035225
0.02544
0.015656
0.02544
0.035225
0.033268
0.04501
0.023483
0.04501
0.04501
0.04501
0.013699
0.033268
0.033268
0.031311
0.013699
0.015656
0.009785
0.031311
0.027397
0.041096
0.021526
0.029354
0.021526
0.043053
0.019569
0.035225
0.041096
1
2,891
C
A
C
G
C
T
G
C
T
C
T
T
T
G
C
T
T
T
G
A
T
G
A
T
G
T
C
C
C
T
T
C
C
T
G
C
G
T
T
G
T
T
T
A
A
C
A
T
C
G
G
C
C
T
C
C
T
A
C
T
C
T
T
C
C
G
0.043053
0.046967
0.046967
0.027397
0.035225
0.02544
0.015656
0.027397
0.035225
0.033268
0.043053
0.023483
0.04501
0.04501
0.04501
0.013699
0.035225
0.033268
0.029354
0.013699
0.015656
0.009785
0.031311
0.027397
0.041096
0.021526
0.029354
0.021526
0.043053
0.019569
0.035225
0.041096
1
2,892
G
C
C
G
A
T
G
T
T
A
A
A
C
A
A
C
G
C
A
G
G
A
A
G
G
G
A
C
A
T
C
A
T
C
A
A
A
G
C
A
A
A
G
A
G
C
A
G
C
G
T
G
C
G
G
A
T
C
C
C
C
T
T
T
G
G
0.04501
0.046967
0.043053
0.031311
0.035225
0.02544
0.015656
0.02544
0.035225
0.029354
0.043053
0.033268
0.04501
0.046967
0.04501
0.013699
0.033268
0.033268
0.029354
0.013699
0.015656
0.009785
0.031311
0.02544
0.039139
0.021526
0.029354
0.021526
0.041096
0.019569
0.037182
0.039139
1
2,893
A
G
G
A
G
C
A
A
A
G
G
G
G
A
T
C
C
G
C
A
C
G
C
T
G
C
T
C
T
T
T
G
C
T
T
T
G
A
T
G
A
T
G
T
C
C
C
T
T
C
C
T
G
C
G
T
T
G
T
T
T
A
A
C
A
T
0.04501
0.048924
0.043053
0.031311
0.037182
0.023483
0.015656
0.02544
0.035225
0.029354
0.041096
0.033268
0.04501
0.046967
0.046967
0.013699
0.031311
0.031311
0.027397
0.013699
0.015656
0.009785
0.031311
0.02544
0.039139
0.023483
0.029354
0.021526
0.041096
0.019569
0.037182
0.041096
1
2,894
G
A
T
C
A
A
A
G
G
A
G
C
A
A
A
G
G
G
G
A
T
C
C
G
C
A
C
G
C
T
G
C
T
C
T
T
T
G
C
T
T
T
G
A
T
G
A
T
G
T
C
C
C
T
T
C
C
T
G
C
G
T
T
G
T
C
0.04501
0.04501
0.041096
0.031311
0.037182
0.023483
0.015656
0.02544
0.035225
0.029354
0.041096
0.041096
0.04501
0.046967
0.046967
0.013699
0.031311
0.031311
0.027397
0.013699
0.015656
0.009785
0.033268
0.02544
0.039139
0.023483
0.029354
0.021526
0.041096
0.019569
0.033268
0.041096
1
2,895
T
C
T
G
A
T
C
A
A
A
G
G
A
G
C
A
A
A
G
G
G
G
A
T
C
C
G
C
A
C
G
C
T
G
C
T
C
T
T
T
G
C
T
T
T
G
A
T
G
A
T
G
T
C
C
C
T
T
C
C
T
G
C
G
T
C
0.043053
0.04501
0.041096
0.031311
0.037182
0.023483
0.015656
0.02544
0.035225
0.029354
0.041096
0.043053
0.04501
0.046967
0.046967
0.013699
0.031311
0.031311
0.027397
0.013699
0.015656
0.009785
0.033268
0.02544
0.039139
0.023483
0.029354
0.021526
0.041096
0.019569
0.033268
0.041096
1
2,896
A
C
G
T
C
T
G
A
T
C
A
A
A
G
G
A
G
C
A
A
A
G
G
G
G
A
T
C
C
G
C
A
C
G
C
T
G
C
T
C
T
T
T
G
C
T
T
T
G
A
T
G
A
T
G
T
C
C
C
T
T
C
C
T
G
A
0.043053
0.04501
0.041096
0.031311
0.037182
0.023483
0.015656
0.02544
0.035225
0.029354
0.041096
0.046967
0.04501
0.046967
0.046967
0.013699
0.031311
0.031311
0.027397
0.013699
0.015656
0.009785
0.031311
0.02544
0.039139
0.023483
0.029354
0.021526
0.041096
0.019569
0.031311
0.041096
1
2,897
G
A
A
G
G
G
A
C
A
T
C
A
T
C
A
A
A
G
C
A
A
A
G
A
G
C
A
G
C
G
T
G
C
G
G
A
T
C
C
C
C
T
T
T
G
C
T
C
C
T
T
T
G
A
T
C
A
G
A
C
G
T
A
G
G
T
0.043053
0.04501
0.041096
0.031311
0.037182
0.021526
0.015656
0.02544
0.035225
0.029354
0.039139
0.052838
0.04501
0.046967
0.046967
0.013699
0.031311
0.031311
0.02544
0.013699
0.015656
0.009785
0.031311
0.02544
0.039139
0.023483
0.029354
0.021526
0.041096
0.019569
0.031311
0.041096
1
2,898
T
C
C
T
A
C
G
T
C
T
G
A
T
C
A
A
A
G
G
A
G
C
A
A
A
G
G
G
G
A
T
C
C
G
C
A
C
G
C
T
G
C
T
C
T
T
T
G
C
T
T
T
G
A
T
G
A
T
G
T
C
C
C
T
T
T
0.043053
0.04501
0.041096
0.031311
0.037182
0.021526
0.015656
0.02544
0.035225
0.029354
0.039139
0.054795
0.04501
0.046967
0.046967
0.013699
0.031311
0.031311
0.02544
0.013699
0.015656
0.009785
0.031311
0.02544
0.039139
0.021526
0.029354
0.021526
0.041096
0.019569
0.031311
0.041096
1
2,899
A
T
C
C
T
A
C
G
T
C
T
G
A
T
C
A
A
A
G
G
A
G
C
A
A
A
G
G
G
G
A
T
C
C
G
C
A
C
G
C
T
G
C
T
C
T
T
T
G
C
T
T
T
G
A
T
G
A
T
G
T
C
C
C
T
G
0.043053
0.04501
0.041096
0.031311
0.037182
0.021526
0.015656
0.02544
0.035225
0.029354
0.039139
0.056751
0.04501
0.046967
0.046967
0.013699
0.031311
0.031311
0.02544
0.013699
0.015656
0.009785
0.031311
0.02544
0.039139
0.021526
0.029354
0.021526
0.041096
0.019569
0.031311
0.039139
1
2,900
G
A
T
T
G
G
C
C
G
A
A
T
C
C
T
A
C
G
T
C
T
G
A
T
C
A
A
A
G
G
A
G
C
A
A
A
G
G
G
G
A
T
C
C
G
C
A
C
G
C
T
G
C
T
C
T
T
T
G
C
T
T
T
G
A
T
0.043053
0.04501
0.041096
0.035225
0.039139
0.019569
0.015656
0.023483
0.035225
0.029354
0.039139
0.060665
0.04501
0.046967
0.048924
0.009785
0.029354
0.031311
0.023483
0.011742
0.013699
0.009785
0.031311
0.02544
0.039139
0.019569
0.029354
0.021526
0.041096
0.023483
0.033268
0.039139
1
2,901
G
C
G
T
G
C
G
G
A
T
C
C
C
C
T
T
T
G
C
T
C
C
T
T
T
G
A
T
C
A
G
A
C
G
T
A
G
G
A
T
T
C
G
G
C
C
A
A
T
C
C
T
A
G
C
A
A
G
A
C
G
G
A
T
C
A
0.04501
0.043053
0.039139
0.041096
0.037182
0.019569
0.015656
0.021526
0.033268
0.027397
0.039139
0.074364
0.04501
0.048924
0.046967
0.009785
0.027397
0.029354
0.023483
0.011742
0.013699
0.009785
0.031311
0.023483
0.037182
0.019569
0.029354
0.019569
0.041096
0.021526
0.037182
0.037182
1
2,902
G
C
G
T
G
C
G
G
A
T
C
C
C
C
T
T
T
G
C
T
C
C
T
T
T
G
A
T
C
A
G
A
C
G
T
A
G
G
A
T
T
C
G
G
C
C
A
A
T
C
C
T
A
G
C
A
A
G
A
C
G
G
A
T
C
G
0.04501
0.043053
0.039139
0.041096
0.037182
0.019569
0.015656
0.021526
0.033268
0.027397
0.039139
0.074364
0.04501
0.048924
0.046967
0.009785
0.027397
0.029354
0.023483
0.011742
0.013699
0.009785
0.031311
0.023483
0.037182
0.019569
0.029354
0.019569
0.041096
0.021526
0.037182
0.037182
1
2,903
G
C
G
T
G
C
G
G
A
T
C
C
C
C
T
T
T
G
C
T
C
C
T
T
T
G
A
T
C
A
G
A
C
G
T
A
G
G
A
T
T
C
G
G
C
C
A
A
T
C
C
T
A
G
C
A
A
G
A
C
G
G
A
T
C
T
0.04501
0.043053
0.039139
0.041096
0.037182
0.019569
0.015656
0.021526
0.033268
0.027397
0.039139
0.074364
0.04501
0.048924
0.046967
0.009785
0.027397
0.029354
0.023483
0.011742
0.013699
0.009785
0.031311
0.023483
0.037182
0.019569
0.029354
0.019569
0.041096
0.021526
0.037182
0.037182
1
2,904
T
G
A
T
C
C
G
T
C
T
T
G
C
T
A
G
G
A
T
T
G
G
C
C
G
A
A
T
C
C
T
A
C
G
T
C
T
G
A
T
C
A
A
A
G
G
A
G
C
A
A
A
G
G
G
G
A
T
C
C
G
C
A
C
G
T
0.04501
0.043053
0.039139
0.039139
0.037182
0.019569
0.015656
0.021526
0.033268
0.027397
0.039139
0.074364
0.046967
0.048924
0.046967
0.009785
0.027397
0.029354
0.023483
0.011742
0.013699
0.009785
0.031311
0.023483
0.037182
0.019569
0.029354
0.019569
0.041096
0.021526
0.037182
0.037182
1
2,905
T
C
C
C
C
T
T
T
G
C
T
C
C
T
T
T
G
A
T
C
A
G
A
C
G
T
A
G
G
A
T
T
C
G
G
C
C
A
A
T
C
C
T
A
G
C
A
A
G
A
C
G
G
A
T
C
A
C
T
C
G
G
A
A
C
G
0.048924
0.043053
0.041096
0.043053
0.037182
0.017613
0.015656
0.021526
0.035225
0.02544
0.039139
0.074364
0.046967
0.046967
0.046967
0.007828
0.027397
0.027397
0.021526
0.011742
0.013699
0.009785
0.029354
0.023483
0.037182
0.019569
0.027397
0.019569
0.041096
0.021526
0.041096
0.037182
1
2,906
T
C
C
C
C
T
T
T
G
C
T
C
C
T
T
T
G
A
T
C
A
G
A
C
G
T
A
G
G
A
T
T
C
G
G
C
C
A
A
T
C
C
T
A
G
C
A
A
G
A
C
G
G
A
T
C
A
C
T
C
G
G
A
A
C
T
0.048924
0.043053
0.041096
0.043053
0.037182
0.017613
0.015656
0.021526
0.035225
0.02544
0.039139
0.074364
0.046967
0.046967
0.046967
0.007828
0.027397
0.027397
0.021526
0.011742
0.013699
0.009785
0.029354
0.023483
0.037182
0.019569
0.027397
0.019569
0.041096
0.021526
0.041096
0.037182
1
2,907
C
C
T
T
T
G
C
T
C
C
T
T
T
G
A
T
C
A
G
A
C
G
T
A
G
G
A
T
T
C
G
G
C
C
A
A
T
C
C
T
A
G
C
A
A
G
A
C
G
G
A
T
C
A
C
T
C
G
G
A
A
C
A
G
G
T
0.048924
0.043053
0.041096
0.043053
0.037182
0.017613
0.015656
0.021526
0.035225
0.023483
0.039139
0.074364
0.046967
0.046967
0.048924
0.007828
0.027397
0.027397
0.021526
0.011742
0.013699
0.009785
0.027397
0.023483
0.039139
0.019569
0.02544
0.019569
0.041096
0.021526
0.041096
0.039139
1
2,908
G
C
T
C
C
T
T
T
G
A
T
C
A
G
A
C
G
T
A
G
G
A
T
T
C
G
G
C
C
A
A
T
C
C
T
A
G
C
A
A
G
A
C
G
G
A
T
C
A
C
T
C
G
G
A
A
C
A
G
G
G
T
A
G
G
G
0.050881
0.043053
0.041096
0.04501
0.037182
0.017613
0.015656
0.021526
0.035225
0.023483
0.039139
0.074364
0.04501
0.046967
0.046967
0.007828
0.027397
0.02544
0.021526
0.011742
0.013699
0.009785
0.027397
0.023483
0.041096
0.019569
0.02544
0.019569
0.039139
0.021526
0.041096
0.041096
1
2,909
C
T
C
C
T
T
T
G
A
T
C
A
G
A
C
G
T
A
G
G
A
T
T
C
G
G
C
C
A
A
T
C
C
T
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G
C
A
A
G
A
C
G
G
A
T
C
A
C
T
C
G
G
A
A
C
A
G
G
G
T
A
G
G
G
A
0.050881
0.043053
0.041096
0.04501
0.037182
0.017613
0.015656
0.021526
0.035225
0.023483
0.039139
0.074364
0.04501
0.04501
0.046967
0.007828
0.029354
0.02544
0.021526
0.011742
0.013699
0.009785
0.027397
0.023483
0.041096
0.019569
0.02544
0.019569
0.039139
0.021526
0.041096
0.041096
1
2,910
T
T
T
G
A
T
C
A
G
A
C
G
T
A
G
G
A
T
T
C
G
G
C
C
A
A
T
C
C
T
A
G
C
A
A
G
A
C
G
G
A
T
C
A
C
T
C
G
G
A
A
C
A
G
G
G
T
A
G
G
G
G
A
C
A
T
0.050881
0.043053
0.041096
0.046967
0.037182
0.017613
0.015656
0.021526
0.035225
0.02544
0.039139
0.074364
0.043053
0.04501
0.048924
0.007828
0.029354
0.023483
0.019569
0.011742
0.013699
0.009785
0.027397
0.023483
0.041096
0.019569
0.027397
0.019569
0.037182
0.021526
0.041096
0.041096
1
2,911
A
T
T
T
C
G
T
G
T
C
C
C
C
T
A
C
C
C
T
G
T
T
C
C
G
A
G
T
G
A
T
C
C
G
T
C
T
T
G
C
T
A
G
G
A
T
T
G
G
C
C
G
A
A
T
C
C
T
A
C
G
T
C
T
G
G
0.052838
0.043053
0.041096
0.050881
0.037182
0.017613
0.015656
0.021526
0.035225
0.021526
0.039139
0.076321
0.043053
0.04501
0.048924
0.007828
0.02544
0.021526
0.019569
0.011742
0.013699
0.009785
0.027397
0.023483
0.043053
0.019569
0.027397
0.017613
0.037182
0.021526
0.043053
0.041096
1
2,912
A
A
G
A
C
G
G
A
T
C
A
C
T
C
G
G
A
A
C
A
G
G
G
T
A
G
G
G
G
A
C
A
C
G
A
A
A
T
A
C
T
T
T
T
C
T
A
T
C
A
G
C
T
C
G
G
C
A
A
G
A
A
A
C
A
G
0.060665
0.041096
0.04501
0.050881
0.035225
0.015656
0.015656
0.02544
0.031311
0.021526
0.037182
0.082192
0.043053
0.04501
0.046967
0.007828
0.021526
0.019569
0.019569
0.011742
0.013699
0.009785
0.027397
0.021526
0.041096
0.019569
0.023483
0.015656
0.037182
0.023483
0.046967
0.043053
1
2,913
A
T
A
T
T
T
C
T
T
A
C
C
T
A
C
A
A
T
G
G
A
G
A
G
A
A
T
G
A
C
A
A
C
C
A
C
A
A
A
A
T
C
A
A
A
A
A
T
A
T
T
C
C
A
T
C
C
A
A
T
G
G
T
A
A
A
0.088063
0.033268
0.031311
0.076321
0.058708
0.021526
0.005871
0.035225
0.052838
0.009785
0.007828
0.048924
0.043053
0.054795
0.046967
0.029354
0.027397
0.035225
0.001957
0
0.001957
0.003914
0.023483
0.023483
0.041096
0.023483
0.007828
0.001957
0.019569
0.035225
0.052838
0.056751
1
2,914
G
T
G
T
A
C
T
G
A
A
A
C
T
C
A
T
C
T
C
T
C
T
A
C
G
C
C
A
T
T
A
T
T
A
T
T
T
T
A
C
C
A
T
T
G
G
A
T
G
G
A
A
T
A
T
T
T
T
T
G
A
T
T
T
T
G
0.09589
0.035225
0.033268
0.074364
0.056751
0.019569
0.005871
0.031311
0.058708
0.011742
0.007828
0.04501
0.043053
0.052838
0.048924
0.027397
0.027397
0.035225
0.001957
0
0.001957
0.003914
0.021526
0.02544
0.04501
0.023483
0.009785
0.001957
0.021526
0.027397
0.050881
0.054795
1
2,915
T
G
G
T
A
A
A
A
T
A
A
T
A
A
T
G
G
C
G
T
A
G
A
G
A
G
A
T
G
A
G
T
T
T
C
A
G
T
A
C
A
C
A
C
T
C
T
C
C
A
G
T
A
A
A
T
A
G
C
A
C
A
A
T
G
A
0.091977
0.033268
0.033268
0.074364
0.056751
0.019569
0.005871
0.035225
0.052838
0.013699
0.007828
0.041096
0.041096
0.058708
0.048924
0.029354
0.027397
0.033268
0.001957
0
0.001957
0.003914
0.019569
0.027397
0.039139
0.023483
0.015656
0.001957
0.019569
0.031311
0.052838
0.056751
1
2,916
G
G
T
G
T
T
C
A
T
T
G
T
G
C
T
A
T
T
T
A
C
T
G
G
A
G
A
G
T
G
T
G
T
A
C
T
G
A
A
A
C
T
C
A
T
C
T
C
T
C
T
A
C
G
C
C
A
T
T
A
T
T
A
T
T
G
0.093933
0.033268
0.035225
0.072407
0.056751
0.019569
0.005871
0.033268
0.054795
0.013699
0.007828
0.039139
0.041096
0.058708
0.046967
0.029354
0.027397
0.033268
0.001957
0
0.001957
0.003914
0.019569
0.027397
0.041096
0.023483
0.017613
0.001957
0.019569
0.029354
0.052838
0.056751
1
2,917
G
G
C
G
T
A
G
A
G
A
G
A
T
G
A
G
T
T
T
C
A
G
T
A
C
A
C
A
C
T
C
T
C
C
A
G
T
A
A
A
T
A
G
C
A
C
A
A
T
G
A
A
C
A
C
C
A
G
A
T
T
G
A
T
G
T
0.093933
0.033268
0.035225
0.078278
0.054795
0.019569
0.005871
0.031311
0.054795
0.013699
0.007828
0.033268
0.041096
0.058708
0.048924
0.029354
0.027397
0.033268
0.001957
0
0.001957
0.003914
0.017613
0.027397
0.041096
0.021526
0.019569
0.001957
0.019569
0.029354
0.056751
0.056751
1
2,918
G
A
T
T
C
T
C
A
T
C
T
G
T
C
T
T
A
A
C
A
T
G
G
T
C
A
C
A
A
T
G
A
T
G
G
T
G
G
A
A
A
C
A
G
A
T
G
A
C
C
A
G
A
G
T
G
A
A
T
A
T
G
T
G
A
G
0.088063
0.031311
0.041096
0.084149
0.04501
0.019569
0.005871
0.037182
0.054795
0.013699
0.007828
0.031311
0.035225
0.060665
0.048924
0.023483
0.023483
0.031311
0.001957
0
0.001957
0.003914
0.02544
0.023483
0.046967
0.023483
0.023483
0.005871
0.015656
0.027397
0.060665
0.056751
1
2,919
C
A
T
G
T
T
A
A
G
A
C
A
G
A
T
G
A
G
A
A
T
C
A
T
G
A
T
G
C
T
T
A
T
G
T
C
A
A
A
A
A
C
T
T
G
T
C
T
G
G
T
T
A
C
G
A
A
G
T
C
A
A
A
G
A
C
0.088063
0.033268
0.033268
0.091977
0.048924
0.019569
0.005871
0.037182
0.052838
0.009785
0.007828
0.037182
0.023483
0.062622
0.04501
0.023483
0.023483
0.033268
0.001957
0
0.001957
0.003914
0.02544
0.02544
0.04501
0.023483
0.02544
0.007828
0.013699
0.031311
0.068493
0.048924
1
2,920
T
G
T
T
A
A
G
A
C
A
G
A
T
G
A
G
A
A
T
C
A
T
G
A
T
G
C
T
T
A
T
G
T
C
A
A
A
A
A
C
T
T
G
T
C
T
G
G
T
T
A
C
G
A
A
G
T
C
A
A
A
G
A
C
C
C
0.088063
0.033268
0.033268
0.091977
0.048924
0.019569
0.005871
0.037182
0.052838
0.009785
0.007828
0.035225
0.023483
0.062622
0.046967
0.023483
0.023483
0.033268
0.001957
0
0.001957
0.003914
0.02544
0.02544
0.04501
0.023483
0.02544
0.007828
0.013699
0.031311
0.068493
0.048924
1
2,921
A
T
A
A
T
G
C
A
A
T
G
A
A
A
A
A
A
T
T
A
G
G
A
T
C
G
A
A
A
A
A
A
C
C
G
C
A
A
A
A
G
C
C
T
A
T
A
C
C
T
C
G
A
C
C
A
G
G
A
G
T
A
A
G
A
T
0.176125
0.027397
0.054795
0.064579
0.04501
0.017613
0
0.029354
0.054795
0.011742
0.015656
0.054795
0.035225
0.039139
0.046967
0.009785
0.015656
0.019569
0.009785
0.001957
0.007828
0.001957
0.027397
0.013699
0.046967
0.015656
0.013699
0.003914
0.015656
0.039139
0.050881
0.033268
1
2,922
G
A
A
A
T
A
C
T
A
T
A
A
T
G
C
A
A
T
G
A
A
A
A
A
A
T
T
A
G
G
A
T
C
G
A
A
A
A
A
A
C
C
G
C
A
A
A
A
G
C
C
T
A
T
A
C
C
T
C
G
A
C
C
A
G
G
0.178082
0.027397
0.052838
0.064579
0.04501
0.017613
0
0.029354
0.050881
0.011742
0.017613
0.054795
0.033268
0.039139
0.04501
0.009785
0.015656
0.019569
0.011742
0.001957
0.007828
0.001957
0.029354
0.011742
0.048924
0.015656
0.013699
0.003914
0.017613
0.039139
0.052838
0.031311
1
2,923
T
C
G
A
G
G
T
A
T
A
G
G
C
T
T
T
T
G
C
G
G
T
T
T
T
T
T
C
G
A
T
C
C
T
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A
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T
T
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C
A
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T
G
C
A
T
T
A
T
A
G
T
A
T
T
T
C
T
T
C
T
G
0.178082
0.027397
0.050881
0.068493
0.04501
0.017613
0
0.027397
0.050881
0.011742
0.017613
0.056751
0.033268
0.039139
0.04501
0.009785
0.015656
0.019569
0.011742
0.001957
0.007828
0.001957
0.029354
0.011742
0.046967
0.013699
0.013699
0.003914
0.017613
0.039139
0.054795
0.031311
1
2,924
C
C
T
A
A
T
T
T
T
T
T
C
A
T
T
G
C
A
T
T
A
T
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G
T
A
T
T
T
C
T
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C
T
G
T
T
C
T
T
C
T
G
T
C
A
T
A
A
A
G
A
T
G
T
C
T
T
G
A
C
C
T
C
C
G
0.181996
0.02544
0.04501
0.078278
0.041096
0.015656
0
0.029354
0.043053
0.011742
0.015656
0.062622
0.033268
0.041096
0.04501
0.007828
0.015656
0.019569
0.009785
0.001957
0.007828
0.001957
0.027397
0.011742
0.041096
0.015656
0.013699
0.003914
0.017613
0.037182
0.064579
0.033268
1
2,925
T
T
G
G
A
G
G
T
C
A
A
G
A
C
A
T
C
T
T
T
A
T
G
A
C
A
G
A
A
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A
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A
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A
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T
A
T
A
A
T
G
C
A
A
T
G
A
A
A
A
A
A
T
T
A
A
0.178082
0.02544
0.04501
0.078278
0.041096
0.015656
0
0.029354
0.043053
0.011742
0.015656
0.062622
0.033268
0.041096
0.04501
0.007828
0.015656
0.019569
0.009785
0.001957
0.007828
0.001957
0.027397
0.011742
0.043053
0.015656
0.013699
0.003914
0.017613
0.037182
0.064579
0.035225
1
2,926
T
T
T
C
T
T
T
T
C
T
A
T
A
C
T
T
T
G
G
A
G
G
T
C
A
A
G
A
C
A
T
C
T
T
T
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T
G
A
C
A
G
A
A
G
A
A
C
A
G
A
A
G
A
A
A
T
A
C
T
A
T
A
A
T
C
0.170254
0.027397
0.04501
0.074364
0.04501
0.015656
0
0.029354
0.043053
0.011742
0.015656
0.062622
0.033268
0.041096
0.046967
0.009785
0.015656
0.019569
0.015656
0.001957
0.007828
0.001957
0.027397
0.011742
0.043053
0.015656
0.013699
0.003914
0.017613
0.037182
0.060665
0.035225
1
2,927
G
A
G
A
A
A
A
T
A
T
T
A
G
A
A
A
T
A
C
T
T
A
T
C
T
T
C
T
T
T
T
T
C
T
G
C
T
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G
T
T
G
A
A
A
T
T
A
T
C
T
A
T
G
A
T
G
A
C
A
C
C
A
A
T
G
0.111546
0.027397
0.048924
0.066536
0.035225
0.019569
0
0.035225
0.052838
0.015656
0.02544
0.080235
0.019569
0.039139
0.027397
0.023483
0.027397
0.029354
0.009785
0.003914
0
0
0.027397
0.02544
0.072407
0.011742
0.009785
0.005871
0.033268
0.027397
0.04501
0.043053
1
2,928
T
T
A
T
T
G
G
T
G
T
C
A
T
C
A
T
A
G
A
T
A
A
T
T
T
C
A
A
C
C
A
G
C
A
G
A
A
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A
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A
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A
T
A
A
G
T
A
T
T
T
C
T
A
A
T
A
T
T
T
T
C
A
0.111546
0.027397
0.048924
0.066536
0.035225
0.019569
0
0.035225
0.050881
0.015656
0.02544
0.080235
0.021526
0.039139
0.027397
0.023483
0.027397
0.029354
0.009785
0.003914
0
0
0.027397
0.02544
0.07045
0.011742
0.009785
0.005871
0.033268
0.027397
0.04501
0.04501
1
2,929
T
T
C
A
T
C
A
T
C
T
T
T
G
G
G
T
C
C
T
T
C
T
T
C
A
C
C
T
T
G
A
A
C
C
T
G
T
T
T
A
T
T
G
G
T
G
T
C
A
T
C
A
T
A
G
A
T
A
A
T
T
T
C
A
A
A
0.11546
0.027397
0.04501
0.066536
0.037182
0.019569
0
0.035225
0.050881
0.015656
0.02544
0.074364
0.021526
0.037182
0.029354
0.023483
0.029354
0.031311
0.011742
0.003914
0
0
0.033268
0.023483
0.066536
0.011742
0.009785
0.009785
0.031311
0.029354
0.043053
0.041096
1
2,930
T
G
A
A
A
T
T
A
T
C
T
A
T
G
A
T
G
A
C
A
C
C
A
A
T
A
A
A
C
A
G
G
T
T
C
A
A
G
G
T
G
A
A
G
A
A
G
G
A
C
C
C
A
A
A
G
A
T
G
A
T
G
A
A
A
C
0.11546
0.027397
0.04501
0.066536
0.037182
0.019569
0
0.035225
0.050881
0.015656
0.027397
0.074364
0.021526
0.037182
0.029354
0.023483
0.029354
0.031311
0.011742
0.003914
0
0
0.031311
0.023483
0.066536
0.011742
0.009785
0.009785
0.031311
0.029354
0.043053
0.041096
1
2,931
T
T
A
T
T
T
T
C
A
T
C
A
T
C
T
T
T
G
G
G
T
C
C
T
T
C
T
T
C
A
C
C
T
T
G
A
A
C
C
T
G
T
T
T
A
T
T
G
G
T
G
T
C
A
T
C
A
T
A
G
A
T
A
A
T
G
0.11546
0.027397
0.04501
0.066536
0.037182
0.019569
0
0.035225
0.050881
0.015656
0.027397
0.072407
0.023483
0.037182
0.029354
0.023483
0.029354
0.031311
0.013699
0.003914
0
0
0.031311
0.023483
0.064579
0.011742
0.009785
0.009785
0.033268
0.029354
0.043053
0.039139
1
2,932
C
T
T
T
G
T
T
A
T
T
T
T
C
A
T
C
A
T
C
T
T
T
G
G
G
T
C
C
T
T
C
T
T
C
A
C
C
T
T
G
A
A
C
C
T
G
T
T
T
A
T
T
G
G
T
G
T
C
A
T
C
A
T
A
G
C
0.119374
0.027397
0.043053
0.066536
0.037182
0.019569
0
0.035225
0.048924
0.015656
0.027397
0.072407
0.023483
0.037182
0.027397
0.023483
0.029354
0.031311
0.013699
0.003914
0
0
0.031311
0.023483
0.066536
0.011742
0.009785
0.009785
0.033268
0.029354
0.043053
0.039139
1
2,933
T
C
T
T
T
A
C
T
T
T
G
T
T
A
T
T
T
T
C
A
T
C
A
T
C
T
T
T
G
G
G
T
C
C
T
T
C
T
T
C
A
C
C
T
T
G
A
A
C
C
T
G
T
T
T
A
T
T
G
G
T
G
T
C
A
T
0.119374
0.027397
0.043053
0.066536
0.037182
0.019569
0
0.033268
0.048924
0.015656
0.027397
0.072407
0.023483
0.041096
0.027397
0.021526
0.029354
0.029354
0.013699
0.003914
0
0
0.031311
0.021526
0.066536
0.011742
0.009785
0.009785
0.033268
0.029354
0.043053
0.043053
1
2,934
C
T
A
A
G
T
A
T
G
A
A
G
A
A
A
G
T
C
T
G
T
A
C
A
T
G
T
A
T
C
T
T
T
A
C
T
T
T
G
T
T
A
T
T
T
T
C
A
T
C
A
T
C
T
T
T
G
G
G
T
C
C
T
T
C
C
0.127202
0.023483
0.039139
0.07045
0.035225
0.019569
0
0.031311
0.046967
0.011742
0.027397
0.074364
0.023483
0.046967
0.027397
0.019569
0.027397
0.031311
0.013699
0.003914
0
0
0.029354
0.021526
0.064579
0.013699
0.009785
0.011742
0.031311
0.029354
0.043053
0.04501
1
2,935
A
A
C
A
A
A
G
T
A
A
A
G
A
T
A
C
A
T
G
T
A
C
A
G
A
C
T
T
T
C
T
T
C
A
T
A
C
T
T
A
G
G
C
T
G
G
A
G
T
T
C
C
A
C
C
T
A
C
C
A
A
A
G
G
G
T
0.133072
0.02544
0.039139
0.072407
0.037182
0.019569
0
0.031311
0.048924
0.011742
0.027397
0.076321
0.023483
0.043053
0.027397
0.017613
0.027397
0.029354
0.013699
0
0
0
0.031311
0.021526
0.060665
0.013699
0.009785
0.009785
0.027397
0.031311
0.048924
0.041096
1
2,936
C
A
A
A
G
T
A
A
A
G
A
T
A
C
A
T
G
T
A
C
A
G
A
C
T
T
T
C
T
T
C
A
T
A
C
T
T
A
G
G
C
T
G
G
A
G
T
T
C
C
A
C
C
T
A
C
C
A
A
A
G
G
G
G
A
C
0.135029
0.02544
0.039139
0.072407
0.035225
0.019569
0
0.031311
0.048924
0.011742
0.027397
0.076321
0.023483
0.043053
0.029354
0.017613
0.027397
0.029354
0.013699
0
0
0
0.031311
0.021526
0.060665
0.011742
0.009785
0.009785
0.027397
0.031311
0.048924
0.041096
1
2,937
A
A
A
A
T
A
T
T
C
C
C
C
T
T
T
G
G
T
A
G
G
T
G
G
A
A
C
T
C
C
A
G
C
C
T
A
A
G
T
A
T
G
A
A
G
A
A
A
G
T
C
T
G
T
A
C
A
T
G
T
A
T
C
T
T
G
0.135029
0.02544
0.037182
0.078278
0.035225
0.019569
0
0.031311
0.046967
0.011742
0.02544
0.082192
0.023483
0.043053
0.029354
0.017613
0.02544
0.029354
0.013699
0
0
0
0.031311
0.019569
0.058708
0.011742
0.009785
0.009785
0.02544
0.031311
0.050881
0.041096
1
2,938
A
A
A
A
T
A
T
T
C
C
C
C
T
T
T
G
G
T
A
G
G
T
G
G
A
A
C
T
C
C
A
G
C
C
T
A
A
G
T
A
T
G
A
A
G
A
A
A
G
T
C
T
G
T
A
C
A
T
G
T
A
T
C
T
T
A
0.135029
0.02544
0.037182
0.078278
0.035225
0.019569
0
0.031311
0.046967
0.011742
0.02544
0.082192
0.023483
0.043053
0.029354
0.017613
0.02544
0.029354
0.013699
0
0
0
0.031311
0.019569
0.058708
0.011742
0.009785
0.009785
0.02544
0.031311
0.050881
0.041096
1
2,939
A
T
G
G
A
T
G
G
A
T
A
T
A
A
T
G
T
A
T
G
C
A
G
C
A
G
T
T
G
A
T
T
C
C
A
G
A
A
A
T
G
T
A
A
G
T
A
T
T
C
C
T
T
G
T
A
T
T
C
T
A
A
G
T
C
A
0.125245
0.02544
0.041096
0.099804
0.046967
0.013699
0.001957
0.02544
0.033268
0.009785
0.015656
0.076321
0.035225
0.050881
0.048924
0.013699
0.019569
0.027397
0.003914
0
0.005871
0
0.021526
0.001957
0.050881
0.015656
0.015656
0.009785
0.021526
0.033268
0.066536
0.043053
1
2,940
A
T
T
C
A
A
A
G
G
A
T
G
G
A
T
G
G
A
T
A
T
A
A
T
G
T
A
T
G
C
A
G
C
A
G
T
T
G
A
T
T
C
C
A
G
A
A
A
T
G
T
A
A
G
T
A
T
T
C
C
T
T
G
T
A
T
0.119374
0.02544
0.041096
0.09589
0.046967
0.013699
0.001957
0.02544
0.033268
0.009785
0.019569
0.074364
0.037182
0.050881
0.048924
0.013699
0.019569
0.027397
0.007828
0
0.005871
0
0.021526
0.003914
0.048924
0.015656
0.015656
0.009785
0.023483
0.033268
0.066536
0.043053
1
2,941
C
A
C
A
T
T
C
A
A
A
G
G
A
T
G
G
A
T
G
G
A
T
A
T
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A
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T
A
T
G
C
A
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C
A
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T
T
G
A
T
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C
C
A
G
A
A
A
T
G
T
A
A
G
T
A
T
T
C
C
T
T
T
0.119374
0.023483
0.043053
0.09589
0.04501
0.013699
0.001957
0.02544
0.033268
0.009785
0.019569
0.074364
0.037182
0.050881
0.048924
0.013699
0.019569
0.027397
0.007828
0
0.005871
0
0.021526
0.003914
0.048924
0.015656
0.015656
0.009785
0.023483
0.033268
0.066536
0.04501
1
2,942
A
G
G
A
A
T
A
C
T
T
A
C
A
T
T
T
C
T
G
G
A
A
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C
A
A
C
T
G
C
T
G
C
A
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C
A
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T
A
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C
C
A
T
C
C
A
T
C
C
T
T
T
G
A
A
T
G
T
G
G
T
0.119374
0.023483
0.043053
0.09589
0.04501
0.013699
0.001957
0.02544
0.033268
0.009785
0.019569
0.074364
0.039139
0.050881
0.048924
0.013699
0.019569
0.027397
0.007828
0
0.005871
0
0.021526
0.003914
0.048924
0.015656
0.015656
0.009785
0.023483
0.033268
0.064579
0.04501
1
2,943
A
T
A
G
G
C
C
A
C
A
T
T
C
A
A
A
G
G
A
T
G
G
A
T
G
G
A
T
A
T
A
A
T
G
T
A
T
G
C
A
G
C
A
G
T
T
G
A
T
T
C
C
A
G
A
A
A
T
G
T
A
A
G
T
A
C
0.119374
0.023483
0.043053
0.09589
0.04501
0.015656
0.001957
0.023483
0.033268
0.009785
0.019569
0.076321
0.039139
0.050881
0.048924
0.013699
0.019569
0.029354
0.007828
0
0.005871
0
0.019569
0.003914
0.048924
0.015656
0.015656
0.009785
0.023483
0.031311
0.064579
0.04501
1
2,944
C
A
T
G
T
C
C
T
T
C
T
T
A
A
T
A
G
G
C
C
A
C
A
T
T
C
A
A
A
G
G
A
T
G
G
A
T
G
G
A
T
A
T
A
A
T
G
T
A
T
G
C
A
G
C
A
G
T
T
G
A
T
T
C
C
C
0.117417
0.02544
0.04501
0.091977
0.04501
0.015656
0.001957
0.02544
0.033268
0.011742
0.019569
0.074364
0.039139
0.046967
0.052838
0.017613
0.019569
0.029354
0.007828
0
0.005871
0
0.017613
0.005871
0.046967
0.015656
0.017613
0.009785
0.023483
0.029354
0.062622
0.04501
1
2,945
A
A
T
C
A
A
C
T
G
C
T
G
C
A
T
A
C
A
T
T
A
T
A
T
C
C
A
T
C
C
A
T
C
C
T
T
T
G
A
A
T
G
T
G
G
C
C
T
A
T
T
A
A
G
A
A
G
G
A
C
A
T
G
C
A
T
0.117417
0.02544
0.046967
0.09002
0.04501
0.015656
0.001957
0.02544
0.033268
0.011742
0.019569
0.074364
0.039139
0.046967
0.052838
0.017613
0.019569
0.029354
0.007828
0
0.005871
0
0.017613
0.005871
0.046967
0.015656
0.017613
0.009785
0.023483
0.029354
0.062622
0.04501
1
2,946
A
T
C
A
A
C
T
G
C
T
G
C
A
T
A
C
A
T
T
A
T
A
T
C
C
A
T
C
C
A
T
C
C
T
T
T
G
A
A
T
G
T
G
G
C
C
T
A
T
T
A
A
G
A
A
G
G
A
C
A
T
G
C
A
T
G
0.119374
0.02544
0.046967
0.09002
0.04501
0.015656
0.001957
0.02544
0.033268
0.011742
0.019569
0.074364
0.039139
0.046967
0.050881
0.017613
0.019569
0.029354
0.007828
0
0.005871
0
0.017613
0.005871
0.046967
0.015656
0.017613
0.009785
0.023483
0.029354
0.062622
0.04501
1