row_idx
int64
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string
f_1_ref__31
string
f_2_ref__30
string
f_3_ref__29
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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f_65_alt
string
f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
2,747
A
C
C
C
C
A
A
C
T
A
T
G
G
C
T
A
C
A
C
G
A
G
C
T
T
T
G
A
C
A
C
C
T
T
T
A
G
T
T
G
G
G
C
C
T
T
T
T
T
G
T
C
C
T
T
A
T
T
T
C
G
T
C
T
C
C
0.091977
0.035225
0.041096
0.050881
0.041096
0.021526
0.013699
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0.029354
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0.011742
0.005871
0.007828
0
0.031311
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0.041096
0.023483
0.021526
0.017613
0.021526
0.027397
0.056751
0.033268
1
2,748
G
G
G
C
C
T
T
T
T
T
G
T
C
C
T
T
A
T
T
T
C
G
T
C
T
C
A
T
G
A
C
T
C
A
A
G
A
C
T
T
C
T
G
G
G
A
A
A
A
C
C
T
T
T
A
T
C
A
A
C
T
G
G
T
G
G
0.097847
0.033268
0.043053
0.054795
0.039139
0.021526
0.013699
0.033268
0.054795
0.023483
0.027397
0.052838
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0.035225
0.02544
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0.027397
0.013699
0.005871
0.007828
0
0.031311
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0.043053
0.021526
0.019569
0.019569
0.019569
0.027397
0.052838
0.037182
1
2,749
T
T
T
T
T
T
G
T
G
C
T
G
G
T
C
A
T
T
T
T
C
T
T
G
G
G
C
T
C
A
T
T
C
T
A
T
C
T
A
A
T
A
A
A
T
T
T
G
A
T
C
T
T
G
G
C
T
G
T
G
G
T
G
G
C
G
0.088063
0.037182
0.043053
0.056751
0.041096
0.023483
0.011742
0.023483
0.056751
0.029354
0.027397
0.046967
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0.039139
0.039139
0.023483
0.039139
0.029354
0.005871
0.003914
0.007828
0
0.02544
0.029354
0.056751
0.017613
0.021526
0.019569
0.017613
0.021526
0.043053
0.048924
1
2,750
C
A
T
A
G
G
C
C
A
T
G
G
C
C
A
C
C
A
C
A
G
C
C
A
A
G
A
T
C
A
A
A
T
T
T
A
T
T
A
G
A
T
A
G
A
A
T
G
A
G
C
C
C
A
A
G
A
A
A
A
T
G
A
C
C
A
0.086106
0.037182
0.043053
0.054795
0.041096
0.023483
0.009785
0.02544
0.056751
0.033268
0.027397
0.04501
0.02544
0.039139
0.039139
0.02544
0.039139
0.029354
0.005871
0.003914
0.005871
0
0.029354
0.031311
0.054795
0.015656
0.023483
0.019569
0.017613
0.021526
0.041096
0.048924
1
2,751
T
C
T
T
G
G
G
C
T
C
A
T
T
C
T
A
T
C
T
A
A
T
A
A
A
T
T
T
G
A
T
C
T
T
G
G
C
T
G
T
G
G
T
G
G
C
C
A
T
G
G
C
C
T
A
T
G
A
G
G
A
A
C
A
G
G
0.088063
0.039139
0.043053
0.054795
0.043053
0.023483
0.009785
0.023483
0.054795
0.033268
0.029354
0.04501
0.02544
0.035225
0.041096
0.02544
0.041096
0.031311
0.005871
0.003914
0.005871
0
0.029354
0.029354
0.054795
0.013699
0.023483
0.021526
0.017613
0.021526
0.041096
0.04501
1
2,752
C
T
G
A
T
T
C
T
G
T
T
C
C
T
C
A
T
A
G
G
C
C
A
T
G
G
C
C
A
C
C
A
C
A
G
C
C
A
A
G
A
T
C
A
A
A
T
T
T
A
T
T
A
G
A
T
A
G
A
A
T
G
A
G
C
A
0.088063
0.041096
0.041096
0.056751
0.043053
0.02544
0.009785
0.023483
0.052838
0.033268
0.029354
0.046967
0.02544
0.035225
0.039139
0.02544
0.041096
0.031311
0.005871
0.003914
0.005871
0
0.029354
0.027397
0.054795
0.011742
0.023483
0.021526
0.017613
0.021526
0.04501
0.043053
1
2,753
G
G
C
C
T
G
A
T
T
C
T
G
T
T
C
C
T
C
A
T
A
G
G
C
C
A
T
G
G
C
C
A
C
C
A
C
A
G
C
C
A
A
G
A
T
C
A
A
A
T
T
T
A
T
T
A
G
A
T
A
G
A
A
T
G
T
0.088063
0.041096
0.041096
0.056751
0.043053
0.02544
0.009785
0.021526
0.054795
0.033268
0.029354
0.046967
0.02544
0.035225
0.039139
0.02544
0.041096
0.031311
0.005871
0.003914
0.005871
0
0.029354
0.027397
0.052838
0.011742
0.023483
0.021526
0.017613
0.021526
0.046967
0.043053
1
2,754
A
T
T
C
T
A
T
C
T
A
A
T
A
A
A
T
T
T
G
A
T
C
T
T
G
G
C
T
G
T
G
G
T
G
G
C
C
A
T
G
G
C
C
T
A
T
G
A
G
G
A
A
C
A
G
A
A
T
C
A
G
G
C
C
A
G
0.088063
0.041096
0.041096
0.056751
0.043053
0.02544
0.009785
0.021526
0.052838
0.033268
0.029354
0.046967
0.02544
0.035225
0.039139
0.02544
0.041096
0.031311
0.005871
0.003914
0.005871
0
0.029354
0.027397
0.054795
0.011742
0.023483
0.021526
0.017613
0.021526
0.046967
0.043053
1
2,755
T
T
C
A
G
C
C
T
C
T
T
C
C
A
A
T
G
T
G
G
C
C
T
G
A
T
T
C
T
G
T
T
C
C
T
C
A
T
A
G
G
C
C
A
T
G
G
C
C
A
C
C
A
C
A
G
C
C
A
A
G
A
T
C
A
T
0.084149
0.041096
0.043053
0.060665
0.043053
0.023483
0.009785
0.02544
0.052838
0.033268
0.027397
0.048924
0.023483
0.035225
0.039139
0.02544
0.039139
0.029354
0.003914
0.003914
0.005871
0
0.029354
0.027397
0.052838
0.011742
0.027397
0.021526
0.015656
0.023483
0.050881
0.041096
1
2,756
G
T
T
C
A
G
C
C
T
C
T
T
C
C
A
A
T
G
T
G
G
C
C
T
G
A
T
T
C
T
G
T
T
C
C
T
C
A
T
A
G
G
C
C
A
T
G
G
C
C
A
C
C
A
C
A
G
C
C
A
A
G
A
T
C
G
0.084149
0.039139
0.043053
0.060665
0.043053
0.023483
0.009785
0.02544
0.052838
0.033268
0.027397
0.048924
0.023483
0.035225
0.041096
0.02544
0.039139
0.029354
0.003914
0.003914
0.005871
0
0.029354
0.027397
0.052838
0.011742
0.027397
0.021526
0.015656
0.023483
0.050881
0.041096
1
2,757
C
A
T
G
G
C
C
T
A
T
G
A
G
G
A
A
C
A
G
A
A
T
C
A
G
G
C
C
A
C
A
T
T
G
G
A
A
G
A
G
G
C
T
G
A
A
C
A
G
A
A
G
G
A
A
G
C
T
G
A
A
T
T
T
C
C
0.080235
0.037182
0.043053
0.064579
0.043053
0.021526
0.009785
0.02544
0.052838
0.033268
0.027397
0.048924
0.02544
0.037182
0.043053
0.02544
0.037182
0.027397
0.003914
0.003914
0.005871
0
0.031311
0.027397
0.050881
0.013699
0.027397
0.021526
0.015656
0.023483
0.048924
0.043053
1
2,758
C
T
G
C
T
G
A
A
A
T
T
C
A
G
C
T
T
C
C
T
T
C
T
G
T
T
C
A
G
C
C
T
C
T
T
C
C
A
A
T
G
T
G
G
C
C
T
G
A
T
T
C
T
G
T
T
C
C
T
C
A
T
A
G
G
G
0.080235
0.037182
0.043053
0.062622
0.04501
0.021526
0.009785
0.02544
0.052838
0.033268
0.027397
0.048924
0.023483
0.035225
0.04501
0.02544
0.037182
0.027397
0.003914
0.003914
0.005871
0
0.031311
0.027397
0.050881
0.015656
0.027397
0.021526
0.015656
0.023483
0.048924
0.043053
1
2,759
C
C
A
A
G
A
C
G
C
A
A
C
A
G
T
A
G
G
G
C
G
A
G
C
C
T
T
T
T
C
A
G
C
T
T
C
A
G
A
G
G
T
C
G
A
G
C
A
A
A
G
G
A
C
A
T
T
G
G
C
T
C
T
G
A
G
0.041096
0.015656
0.04501
0.031311
0.041096
0.021526
0.009785
0.02544
0.052838
0.041096
0.037182
0.009785
0.017613
0.056751
0.035225
0.035225
0.048924
0.041096
0.029354
0.011742
0.011742
0.013699
0.011742
0.050881
0.043053
0.037182
0.041096
0.037182
0.031311
0.009785
0.011742
0.052838
1
2,760
A
A
C
T
T
G
A
A
G
A
A
T
C
C
A
G
A
C
A
G
A
A
A
T
G
C
C
C
A
C
C
A
T
G
C
T
G
G
T
A
T
A
A
A
T
T
T
G
C
T
A
A
T
A
T
G
T
G
T
T
T
G
A
T
T
C
0.088063
0.04501
0.04501
0.050881
0.041096
0.031311
0.001957
0.031311
0.043053
0.033268
0.027397
0.031311
0.02544
0.04501
0.037182
0.017613
0.046967
0.048924
0.013699
0.001957
0
0
0.021526
0.021526
0.043053
0.017613
0.02544
0.015656
0.033268
0.02544
0.058708
0.031311
1
2,761
C
A
T
G
G
G
A
T
A
G
T
G
C
T
C
C
A
T
A
G
C
C
A
T
G
A
A
G
A
G
T
G
T
A
T
T
T
A
A
G
A
C
A
A
T
G
C
A
G
A
T
G
G
T
G
A
T
G
G
C
C
A
G
G
T
C
0.097847
0.041096
0.041096
0.064579
0.039139
0.029354
0.001957
0.033268
0.043053
0.023483
0.021526
0.037182
0.023483
0.050881
0.048924
0.021526
0.033268
0.04501
0.009785
0.001957
0
0
0.019569
0.02544
0.037182
0.019569
0.031311
0.015656
0.023483
0.021526
0.058708
0.039139
1
2,762
A
T
T
T
T
A
T
G
A
A
C
A
C
T
C
C
C
A
G
T
T
A
A
T
T
T
A
C
C
A
G
C
C
G
G
A
A
T
G
A
T
C
G
G
A
G
A
A
C
T
G
A
C
A
A
T
C
C
T
T
C
C
A
C
A
G
0.066536
0.033268
0.048924
0.091977
0.031311
0.013699
0.001957
0.041096
0.043053
0.017613
0.017613
0.052838
0.027397
0.046967
0.04501
0.021526
0.015656
0.039139
0.009785
0.005871
0.003914
0
0.027397
0.027397
0.060665
0.007828
0.013699
0.015656
0.033268
0.02544
0.068493
0.04501
1
2,763
T
T
T
C
C
A
G
C
T
C
C
G
A
G
T
T
T
T
C
A
A
G
T
T
G
G
C
A
A
A
A
T
C
T
T
G
G
C
C
A
A
C
T
C
T
A
A
A
T
A
T
G
C
T
A
A
T
T
A
A
G
A
T
C
A
A
0.109589
0.023483
0.031311
0.072407
0.048924
0.017613
0.007828
0.023483
0.041096
0.02544
0.021526
0.039139
0.023483
0.04501
0.039139
0.039139
0.033268
0.039139
0.013699
0.005871
0.007828
0.005871
0.019569
0.027397
0.029354
0.015656
0.046967
0.019569
0.027397
0.019569
0.058708
0.021526
1
2,764
G
G
C
C
A
A
T
A
C
C
A
A
G
G
T
G
A
G
G
T
T
T
C
C
T
A
G
A
G
C
C
C
C
C
A
C
A
G
A
A
T
T
G
C
C
A
A
T
G
A
T
C
T
T
A
A
T
T
A
G
C
A
T
A
T
T
0.105675
0.021526
0.035225
0.060665
0.046967
0.019569
0.007828
0.02544
0.039139
0.027397
0.021526
0.035225
0.023483
0.050881
0.037182
0.041096
0.033268
0.046967
0.013699
0.005871
0.009785
0.007828
0.017613
0.027397
0.031311
0.019569
0.046967
0.023483
0.031311
0.015656
0.048924
0.021526
1
2,765
A
G
A
C
G
A
T
G
A
T
G
G
C
C
A
A
T
A
C
C
A
A
G
G
T
G
A
G
G
T
T
T
C
C
T
A
G
A
G
C
C
C
C
C
A
C
A
G
A
A
T
T
G
C
C
A
A
T
G
A
T
C
T
T
A
T
0.099804
0.021526
0.035225
0.058708
0.04501
0.021526
0.007828
0.02544
0.037182
0.027397
0.021526
0.035225
0.023483
0.058708
0.037182
0.041096
0.031311
0.048924
0.013699
0.005871
0.009785
0.007828
0.017613
0.027397
0.029354
0.021526
0.046967
0.023483
0.029354
0.015656
0.048924
0.02544
1
2,766
T
T
G
G
A
A
A
T
C
T
T
G
C
A
G
A
C
A
C
A
T
T
C
T
T
T
G
T
A
G
C
T
C
T
T
A
C
C
A
A
A
G
A
G
C
T
G
C
A
T
G
C
C
G
A
C
C
A
C
A
G
C
A
A
A
G
0.113503
0.019569
0.031311
0.066536
0.037182
0.021526
0.007828
0.021526
0.041096
0.029354
0.015656
0.031311
0.031311
0.060665
0.039139
0.035225
0.027397
0.052838
0.009785
0.005871
0.009785
0.007828
0.019569
0.029354
0.033268
0.017613
0.041096
0.023483
0.029354
0.015656
0.043053
0.031311
1
2,767
A
T
G
A
C
T
T
T
T
T
C
C
A
C
T
C
C
T
T
C
C
T
G
A
T
C
G
T
G
T
T
C
C
G
C
G
T
G
C
T
G
T
G
T
G
G
A
G
A
G
T
G
G
A
T
A
G
A
G
A
C
C
A
T
G
T
0.072407
0.019569
0.037182
0.054795
0.04501
0.021526
0.007828
0.031311
0.039139
0.027397
0.019569
0.029354
0.031311
0.064579
0.043053
0.039139
0.02544
0.056751
0.009785
0.005871
0.009785
0.007828
0.023483
0.031311
0.037182
0.021526
0.029354
0.029354
0.031311
0.023483
0.033268
0.041096
1
2,768
A
C
A
T
G
G
T
C
T
C
T
A
T
C
C
A
C
T
C
T
C
C
A
C
A
C
A
G
C
A
C
G
C
G
G
A
A
C
A
C
G
A
T
C
A
G
G
A
A
G
G
A
G
T
G
G
A
A
A
A
A
G
T
C
A
T
0.072407
0.021526
0.037182
0.054795
0.04501
0.021526
0.007828
0.031311
0.039139
0.027397
0.019569
0.029354
0.031311
0.064579
0.043053
0.039139
0.02544
0.056751
0.009785
0.005871
0.009785
0.007828
0.023483
0.031311
0.037182
0.021526
0.029354
0.029354
0.031311
0.023483
0.031311
0.041096
1
2,769
C
C
T
G
T
T
T
T
T
C
C
T
G
C
T
G
T
G
T
T
T
C
A
G
G
T
T
C
T
G
A
A
C
C
T
C
T
T
C
T
T
G
G
C
C
T
T
G
C
T
T
T
T
G
A
G
T
T
C
C
T
T
C
A
G
A
0.111546
0.031311
0.048924
0.082192
0.029354
0.017613
0.005871
0.019569
0.046967
0.033268
0.021526
0.048924
0.037182
0.039139
0.041096
0.019569
0.039139
0.019569
0.001957
0.001957
0.005871
0.001957
0.029354
0.005871
0.074364
0.009785
0.035225
0.007828
0.017613
0.011742
0.046967
0.056751
1
2,770
A
T
T
C
C
T
T
C
A
A
A
C
C
G
G
G
A
C
A
A
A
G
C
T
C
T
C
A
G
T
G
G
C
C
T
C
A
G
A
G
C
T
C
T
T
A
G
T
G
T
T
C
T
G
A
G
G
G
A
T
T
T
G
A
T
A
0.062622
0.029354
0.035225
0.064579
0.043053
0.021526
0
0.048924
0.048924
0.029354
0.019569
0.041096
0.017613
0.037182
0.046967
0.027397
0.046967
0.031311
0.021526
0.003914
0.003914
0
0.023483
0.041096
0.035225
0.027397
0.029354
0.017613
0.013699
0.029354
0.046967
0.054795
1
2,771
T
T
A
C
C
C
T
C
A
T
T
C
C
T
T
C
A
A
A
C
C
G
G
G
A
C
A
A
A
G
C
T
C
T
C
A
G
T
G
G
C
C
T
C
A
G
A
G
C
T
C
T
T
A
G
T
G
T
T
C
T
G
A
G
G
T
0.064579
0.027397
0.033268
0.066536
0.043053
0.021526
0
0.046967
0.050881
0.031311
0.019569
0.041096
0.019569
0.037182
0.04501
0.027397
0.046967
0.029354
0.017613
0.003914
0.003914
0
0.027397
0.041096
0.035225
0.027397
0.029354
0.017613
0.013699
0.029354
0.046967
0.054795
1
2,772
A
G
G
C
A
T
T
C
A
G
T
C
T
T
A
C
C
C
T
C
A
T
T
C
C
T
T
C
A
A
A
C
C
G
G
G
A
C
A
A
A
G
C
T
C
T
C
A
G
T
G
G
C
C
T
C
A
G
A
G
C
T
C
T
T
T
0.064579
0.027397
0.035225
0.066536
0.043053
0.021526
0
0.04501
0.050881
0.031311
0.019569
0.041096
0.019569
0.037182
0.046967
0.029354
0.04501
0.031311
0.017613
0.003914
0.003914
0
0.02544
0.041096
0.041096
0.023483
0.029354
0.017613
0.015656
0.027397
0.043053
0.054795
1
2,773
A
G
G
C
A
T
T
C
A
G
T
C
T
T
A
C
C
C
T
C
A
T
T
C
C
T
T
C
A
A
A
C
C
G
G
G
A
C
A
A
A
G
C
T
C
T
C
A
G
T
G
G
C
C
T
C
A
G
A
G
C
T
C
T
T
A
0.064579
0.027397
0.035225
0.066536
0.043053
0.021526
0
0.04501
0.050881
0.031311
0.019569
0.041096
0.019569
0.037182
0.046967
0.029354
0.04501
0.031311
0.017613
0.003914
0.003914
0
0.02544
0.041096
0.041096
0.023483
0.029354
0.017613
0.015656
0.027397
0.043053
0.054795
1
2,774
G
A
C
A
A
A
C
T
C
T
A
A
G
G
C
A
T
T
C
A
G
T
C
T
T
A
C
C
C
T
C
A
T
T
C
C
T
T
C
A
A
A
C
C
G
G
G
A
C
A
A
A
G
C
T
C
T
C
A
G
T
G
G
C
C
C
0.068493
0.027397
0.035225
0.066536
0.043053
0.021526
0
0.043053
0.052838
0.029354
0.019569
0.043053
0.021526
0.037182
0.04501
0.029354
0.043053
0.029354
0.017613
0.003914
0.003914
0
0.027397
0.041096
0.041096
0.023483
0.027397
0.017613
0.015656
0.027397
0.043053
0.054795
1
2,775
C
T
T
A
T
T
T
T
T
C
C
T
T
C
T
C
A
T
C
C
T
G
T
G
C
C
A
G
G
T
T
G
T
T
G
T
A
A
A
T
G
C
T
C
T
T
T
T
A
G
G
A
G
C
C
A
T
T
C
C
A
T
C
T
A
A
0.101761
0.041096
0.037182
0.07045
0.04501
0.019569
0.007828
0.039139
0.04501
0.023483
0.015656
0.041096
0.027397
0.037182
0.056751
0.023483
0.027397
0.037182
0.003914
0
0.001957
0.001957
0.021526
0.037182
0.037182
0.009785
0.017613
0.011742
0.021526
0.037182
0.056751
0.04501
1
2,776
A
T
T
C
A
T
G
A
T
A
G
A
T
G
G
A
A
T
G
G
C
T
C
C
T
A
A
A
A
G
A
G
C
A
T
T
T
A
C
A
A
C
A
A
C
C
T
G
G
C
A
C
A
G
G
A
T
G
A
G
A
A
G
G
A
A
0.099804
0.041096
0.037182
0.07045
0.046967
0.017613
0.007828
0.039139
0.046967
0.023483
0.013699
0.04501
0.031311
0.037182
0.054795
0.023483
0.029354
0.037182
0.003914
0
0.001957
0.001957
0.021526
0.035225
0.037182
0.011742
0.017613
0.011742
0.021526
0.035225
0.054795
0.043053
1
2,777
A
A
C
C
A
G
A
A
G
T
A
C
A
T
T
C
A
T
G
A
T
A
G
A
T
G
G
A
A
T
G
G
C
T
C
C
T
A
A
A
A
G
A
G
C
A
T
T
T
A
C
A
A
C
A
A
C
C
T
G
G
C
A
C
A
T
0.09589
0.041096
0.041096
0.066536
0.04501
0.017613
0.007828
0.043053
0.050881
0.021526
0.013699
0.04501
0.031311
0.033268
0.054795
0.023483
0.029354
0.037182
0.003914
0
0.001957
0.001957
0.021526
0.037182
0.039139
0.011742
0.015656
0.011742
0.021526
0.035225
0.054795
0.04501
1
2,778
A
A
C
C
A
G
A
A
G
T
A
C
A
T
T
C
A
T
G
A
T
A
G
A
T
G
G
A
A
T
G
G
C
T
C
C
T
A
A
A
A
G
A
G
C
A
T
T
T
A
C
A
A
C
A
A
C
C
T
G
G
C
A
C
A
A
0.09589
0.041096
0.041096
0.066536
0.04501
0.017613
0.007828
0.043053
0.050881
0.021526
0.013699
0.04501
0.031311
0.033268
0.054795
0.023483
0.029354
0.037182
0.003914
0
0.001957
0.001957
0.021526
0.037182
0.039139
0.011742
0.015656
0.011742
0.021526
0.035225
0.054795
0.04501
1
2,779
T
A
G
C
C
A
A
A
A
G
A
T
C
A
G
A
C
A
A
A
C
C
A
G
A
A
G
T
A
C
A
T
T
C
A
T
G
A
T
A
G
A
T
G
G
A
A
T
G
G
C
T
C
C
T
A
A
A
A
G
A
G
C
A
T
C
0.097847
0.039139
0.043053
0.066536
0.039139
0.015656
0.007828
0.048924
0.048924
0.021526
0.011742
0.04501
0.033268
0.033268
0.052838
0.021526
0.029354
0.037182
0.003914
0
0.001957
0.001957
0.023483
0.035225
0.039139
0.011742
0.015656
0.011742
0.021526
0.039139
0.056751
0.04501
1
2,780
A
A
C
A
G
C
T
G
C
A
T
A
C
A
T
A
A
T
A
T
C
C
A
T
C
C
A
T
C
C
C
T
T
A
A
A
C
G
T
G
G
C
C
T
G
T
A
A
G
A
A
A
A
G
T
C
A
T
A
T
C
A
T
T
T
C
0.113503
0.019569
0.029354
0.117417
0.041096
0.001957
0.005871
0.019569
0.033268
0.011742
0.013699
0.121331
0.04501
0.046967
0.043053
0.013699
0.011742
0.013699
0.011742
0
0.003914
0.001957
0.029354
0.007828
0.037182
0.007828
0.017613
0.007828
0.017613
0.027397
0.084149
0.043053
1
2,781
A
A
C
C
A
A
A
A
A
T
A
A
T
A
A
A
G
A
T
G
A
C
A
A
A
A
T
A
A
A
G
A
T
A
C
A
T
G
T
A
C
A
G
G
T
T
G
T
C
T
T
C
A
T
A
C
T
T
G
G
G
T
T
G
T
C
0.109589
0.035225
0.056751
0.082192
0.033268
0.02544
0
0.029354
0.052838
0.013699
0.015656
0.072407
0.033268
0.048924
0.04501
0.011742
0.017613
0.021526
0.003914
0
0.003914
0
0.021526
0.015656
0.060665
0.011742
0.015656
0.001957
0.009785
0.029354
0.068493
0.052838
1
2,782
A
G
A
C
A
A
C
C
T
G
T
A
C
A
T
G
T
A
T
C
T
T
T
A
T
T
T
T
G
T
C
A
T
C
T
T
T
A
T
T
A
T
T
T
T
T
G
G
T
T
C
A
T
T
C
T
T
T
A
C
C
T
T
G
A
A
0.111546
0.035225
0.054795
0.084149
0.035225
0.023483
0
0.027397
0.052838
0.015656
0.015656
0.066536
0.035225
0.050881
0.04501
0.011742
0.019569
0.019569
0.003914
0
0.003914
0
0.021526
0.015656
0.060665
0.009785
0.017613
0.001957
0.009785
0.029354
0.066536
0.054795
1
2,783
T
T
A
T
T
A
T
T
T
T
T
G
G
T
T
C
A
T
T
C
T
T
T
A
C
C
T
T
G
A
A
T
C
T
T
T
T
C
A
T
T
G
G
T
G
T
C
A
T
C
A
T
A
G
A
T
A
A
C
T
T
C
A
A
C
G
0.117417
0.033268
0.052838
0.082192
0.035225
0.021526
0
0.029354
0.052838
0.015656
0.013699
0.076321
0.037182
0.050881
0.04501
0.011742
0.015656
0.019569
0.001957
0
0.003914
0
0.027397
0.015656
0.054795
0.011742
0.013699
0.001957
0.007828
0.027397
0.068493
0.054795
1
2,784
C
T
T
A
T
C
T
T
C
T
T
T
T
T
C
T
G
T
T
G
G
T
T
G
A
A
G
T
T
A
T
C
T
A
T
G
A
T
G
A
C
A
C
C
A
A
T
G
A
A
A
A
G
A
T
T
C
A
A
G
G
T
A
A
A
C
0.119374
0.033268
0.048924
0.088063
0.033268
0.021526
0
0.027397
0.048924
0.013699
0.013699
0.088063
0.037182
0.048924
0.04501
0.009785
0.015656
0.019569
0.001957
0
0.003914
0
0.027397
0.011742
0.054795
0.011742
0.013699
0.003914
0.007828
0.027397
0.07045
0.052838
1
2,785
T
T
G
A
A
T
C
T
T
T
T
C
A
T
T
G
G
T
G
T
C
A
T
C
A
T
A
G
A
T
A
A
C
T
T
C
A
A
C
C
A
A
C
A
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A
A
A
A
A
G
A
A
G
A
T
A
A
G
T
A
T
A
T
T
G
0.119374
0.033268
0.050881
0.086106
0.033268
0.021526
0
0.027397
0.048924
0.013699
0.015656
0.088063
0.035225
0.048924
0.043053
0.009785
0.015656
0.019569
0.001957
0
0.003914
0
0.027397
0.011742
0.052838
0.011742
0.015656
0.005871
0.007828
0.027397
0.072407
0.050881
1
2,786
T
T
T
T
C
A
T
T
G
G
T
G
T
C
A
T
C
A
T
A
G
A
T
A
A
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T
T
C
A
A
C
C
A
A
C
A
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A
A
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A
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A
A
G
A
T
A
A
G
T
A
T
A
T
T
A
A
A
A
C
T
T
A
0.119374
0.031311
0.048924
0.086106
0.033268
0.019569
0
0.027397
0.052838
0.013699
0.013699
0.09002
0.037182
0.048924
0.043053
0.009785
0.015656
0.019569
0.001957
0
0.003914
0
0.029354
0.013699
0.050881
0.011742
0.015656
0.005871
0.007828
0.027397
0.072407
0.048924
1
2,787
T
C
T
T
C
T
G
T
T
C
T
T
C
T
G
T
C
A
T
A
A
A
A
A
T
G
T
C
T
T
G
A
C
C
T
C
C
A
A
A
G
T
A
A
A
G
A
A
A
T
G
A
A
A
G
C
A
A
C
A
C
T
T
G
T
T
0.119374
0.039139
0.037182
0.080235
0.048924
0.019569
0.001957
0.027397
0.037182
0.029354
0.017613
0.07045
0.019569
0.041096
0.04501
0.017613
0.019569
0.021526
0.009785
0.003914
0.009785
0
0.04501
0.009785
0.04501
0.015656
0.019569
0.013699
0.009785
0.02544
0.066536
0.033268
1
2,788
T
G
C
A
T
T
G
T
A
G
T
A
T
T
T
C
T
T
C
T
G
T
T
C
T
T
C
T
G
T
C
A
T
A
A
A
A
A
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G
T
C
T
T
G
A
C
C
T
C
C
A
A
A
G
T
A
A
A
G
A
A
A
T
G
C
0.113503
0.039139
0.037182
0.080235
0.048924
0.019569
0.001957
0.027397
0.035225
0.029354
0.017613
0.084149
0.017613
0.043053
0.041096
0.017613
0.019569
0.021526
0.009785
0.003914
0.009785
0
0.04501
0.007828
0.04501
0.013699
0.019569
0.013699
0.009785
0.027397
0.07045
0.029354
1
2,789
T
T
G
T
G
G
T
T
T
C
T
T
T
G
A
A
C
C
C
A
G
T
T
T
T
T
T
C
A
T
T
G
C
A
T
T
G
T
A
G
T
A
T
T
T
C
T
T
C
T
G
T
T
C
T
T
C
T
G
T
C
A
T
A
A
T
0.11546
0.041096
0.031311
0.076321
0.052838
0.019569
0.001957
0.027397
0.035225
0.023483
0.017613
0.09589
0.013699
0.048924
0.039139
0.017613
0.019569
0.021526
0.009785
0.003914
0.005871
0
0.04501
0.007828
0.04501
0.013699
0.021526
0.013699
0.009785
0.029354
0.066536
0.029354
1
2,790
T
T
A
C
A
G
C
A
G
G
T
C
G
A
G
G
T
A
T
G
G
G
T
T
T
T
T
G
T
G
G
T
T
T
C
T
T
T
G
A
A
C
C
C
A
G
T
T
T
T
T
T
C
A
T
T
G
C
A
T
T
G
T
A
G
A
0.109589
0.041096
0.031311
0.076321
0.056751
0.019569
0.001957
0.027397
0.035225
0.021526
0.017613
0.105675
0.009785
0.050881
0.037182
0.017613
0.017613
0.021526
0.009785
0.003914
0.005871
0
0.04501
0.007828
0.043053
0.013699
0.019569
0.013699
0.009785
0.033268
0.07045
0.02544
1
2,791
G
G
C
A
A
T
G
A
A
A
A
T
A
T
G
T
T
A
T
T
C
T
T
A
C
A
G
C
A
G
G
T
C
G
A
G
G
T
A
T
G
G
G
T
T
T
T
T
G
T
G
G
T
T
T
C
T
T
T
G
A
A
C
C
C
T
0.11546
0.041096
0.033268
0.078278
0.056751
0.019569
0.001957
0.02544
0.031311
0.023483
0.017613
0.105675
0.009785
0.048924
0.039139
0.017613
0.017613
0.021526
0.009785
0.003914
0.005871
0
0.039139
0.007828
0.043053
0.009785
0.021526
0.013699
0.009785
0.035225
0.072407
0.023483
1
2,792
T
T
T
T
G
T
A
A
C
C
A
A
A
C
A
A
G
T
C
T
T
T
G
A
T
A
T
C
A
G
C
A
T
C
A
T
G
A
T
C
C
T
C
A
T
C
T
G
C
C
T
T
A
A
C
A
T
G
G
T
C
A
C
C
A
C
0.111546
0.039139
0.043053
0.066536
0.046967
0.033268
0.001957
0.02544
0.04501
0.015656
0.023483
0.031311
0.039139
0.043053
0.048924
0.029354
0.029354
0.041096
0
0.001957
0.007828
0
0.015656
0.023483
0.050881
0.015656
0.015656
0.003914
0.029354
0.023483
0.050881
0.046967
1
2,793
C
T
G
G
T
C
A
T
C
G
G
T
T
T
C
C
A
C
C
A
T
C
A
T
G
G
T
G
A
C
C
A
T
G
T
T
A
A
G
G
C
A
G
A
T
G
A
G
G
A
T
C
A
T
G
A
T
G
C
T
G
A
T
A
T
C
0.123288
0.041096
0.039139
0.068493
0.048924
0.029354
0.001957
0.02544
0.046967
0.015656
0.017613
0.035225
0.039139
0.04501
0.04501
0.029354
0.029354
0.041096
0
0.001957
0.007828
0
0.015656
0.023483
0.050881
0.013699
0.013699
0.001957
0.029354
0.021526
0.052838
0.04501
1
2,794
C
C
G
A
T
G
A
C
C
A
G
A
G
T
C
A
A
G
A
A
A
T
G
A
C
A
A
A
C
A
T
T
C
T
G
T
A
C
T
G
G
A
T
T
A
A
T
C
T
G
G
T
G
T
T
T
A
T
T
G
T
T
C
T
G
G
0.11546
0.041096
0.039139
0.068493
0.04501
0.029354
0.001957
0.027397
0.050881
0.011742
0.017613
0.037182
0.043053
0.046967
0.039139
0.029354
0.02544
0.041096
0.003914
0.001957
0.007828
0
0.019569
0.023483
0.054795
0.013699
0.009785
0.001957
0.029354
0.019569
0.056751
0.046967
1
2,795
A
A
A
C
A
T
T
C
T
G
T
A
C
T
G
G
A
T
T
A
A
T
C
T
G
G
T
G
T
T
T
A
T
T
G
T
T
C
T
G
T
T
C
A
C
T
G
G
A
G
A
A
T
G
T
G
T
G
C
T
G
A
A
A
C
C
0.11546
0.04501
0.037182
0.07045
0.043053
0.029354
0.001957
0.033268
0.048924
0.011742
0.015656
0.035225
0.039139
0.046967
0.041096
0.027397
0.02544
0.043053
0.003914
0.001957
0.007828
0
0.02544
0.021526
0.054795
0.015656
0.009785
0.001957
0.029354
0.019569
0.052838
0.04501
1
2,796
T
C
T
G
T
A
C
T
G
G
A
T
T
A
A
T
C
T
G
G
T
G
T
T
T
A
T
T
G
T
T
C
T
G
T
T
C
A
C
T
G
G
A
G
A
A
T
G
T
G
T
G
C
T
G
A
A
A
C
T
G
A
T
C
T
C
0.113503
0.04501
0.035225
0.072407
0.043053
0.029354
0.001957
0.033268
0.048924
0.007828
0.015656
0.035225
0.039139
0.048924
0.043053
0.027397
0.02544
0.04501
0.003914
0.001957
0.007828
0
0.023483
0.021526
0.054795
0.015656
0.011742
0.003914
0.029354
0.017613
0.052838
0.04501
1
2,797
A
C
G
A
A
G
A
G
A
G
A
T
C
A
G
T
T
T
C
A
G
C
A
C
A
C
A
T
T
C
T
C
C
A
G
T
G
A
A
C
A
G
A
A
C
A
A
T
A
A
A
C
A
C
C
A
G
A
T
T
A
A
T
C
C
T
0.107632
0.04501
0.035225
0.072407
0.041096
0.029354
0.001957
0.033268
0.052838
0.007828
0.015656
0.035225
0.039139
0.046967
0.041096
0.027397
0.02544
0.04501
0.003914
0.001957
0.007828
0
0.02544
0.023483
0.056751
0.015656
0.011742
0.003914
0.029354
0.017613
0.054795
0.04501
1
2,798
A
A
T
G
A
C
C
A
C
C
A
C
A
A
A
A
T
C
A
A
A
A
A
T
A
T
T
C
C
A
T
C
C
A
A
T
A
G
T
G
A
A
A
T
A
G
T
A
G
T
A
A
C
G
A
A
G
A
G
A
G
A
T
C
A
T
0.09589
0.041096
0.031311
0.072407
0.043053
0.027397
0.001957
0.035225
0.04501
0.009785
0.015656
0.043053
0.037182
0.054795
0.043053
0.031311
0.02544
0.046967
0.003914
0.001957
0.003914
0
0.023483
0.02544
0.052838
0.015656
0.017613
0.003914
0.033268
0.019569
0.048924
0.048924
1
2,799
T
C
G
T
T
A
C
T
A
C
T
A
T
T
T
C
A
C
T
A
T
T
G
G
A
T
G
G
A
A
T
A
T
T
T
T
T
G
A
T
T
T
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T
G
G
T
G
G
T
C
A
T
T
C
T
C
T
C
C
A
T
T
G
G
0.097847
0.039139
0.031311
0.072407
0.043053
0.027397
0.001957
0.033268
0.04501
0.013699
0.015656
0.043053
0.037182
0.054795
0.043053
0.031311
0.027397
0.04501
0.003914
0.001957
0.003914
0
0.023483
0.02544
0.052838
0.015656
0.017613
0.003914
0.031311
0.019569
0.046967
0.050881
1
2,800
G
T
T
A
C
T
A
C
T
A
T
T
T
C
A
C
T
A
T
T
G
G
A
T
G
G
A
A
T
A
T
T
T
T
T
G
A
T
T
T
T
G
T
G
G
T
G
G
T
C
A
T
T
C
T
C
T
C
C
A
T
T
G
T
A
C
0.09589
0.039139
0.031311
0.072407
0.043053
0.027397
0.001957
0.033268
0.04501
0.013699
0.015656
0.04501
0.037182
0.054795
0.043053
0.031311
0.027397
0.04501
0.003914
0.001957
0.003914
0
0.023483
0.02544
0.052838
0.015656
0.017613
0.003914
0.031311
0.019569
0.046967
0.050881
1
2,801
T
A
T
T
T
G
T
T
G
A
T
T
T
T
C
T
A
C
A
G
G
A
A
T
G
T
T
T
C
T
G
G
C
T
G
A
A
C
T
G
A
T
A
G
A
A
A
A
G
T
A
T
T
T
T
G
T
G
T
C
C
C
C
T
A
G
0.082192
0.048924
0.041096
0.04501
0.058708
0.009785
0.011742
0.02544
0.027397
0.015656
0.037182
0.048924
0.046967
0.054795
0.050881
0.009785
0.027397
0.021526
0.019569
0.009785
0.009785
0.007828
0.02544
0.011742
0.039139
0.015656
0.027397
0.019569
0.039139
0.031311
0.043053
0.037182
1
2,802
T
G
G
C
T
G
A
A
C
T
G
A
T
A
G
A
A
A
A
G
T
A
T
T
T
T
G
T
G
T
C
C
C
C
T
A
C
C
C
T
G
T
T
C
C
G
A
G
T
G
A
T
C
C
G
T
C
T
T
G
C
C
A
G
G
T
0.076321
0.048924
0.039139
0.043053
0.060665
0.011742
0.011742
0.023483
0.029354
0.015656
0.037182
0.046967
0.046967
0.056751
0.054795
0.009785
0.031311
0.023483
0.019569
0.009785
0.009785
0.007828
0.019569
0.013699
0.033268
0.017613
0.031311
0.023483
0.035225
0.031311
0.043053
0.037182
1
2,803
G
G
C
T
G
A
A
C
T
G
A
T
A
G
A
A
A
A
G
T
A
T
T
T
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T
G
T
C
C
C
C
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C
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T
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C
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A
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G
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C
C
A
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G
A
G
0.076321
0.048924
0.039139
0.043053
0.060665
0.011742
0.011742
0.023483
0.029354
0.015656
0.037182
0.046967
0.046967
0.054795
0.054795
0.009785
0.033268
0.023483
0.019569
0.009785
0.009785
0.007828
0.019569
0.013699
0.033268
0.017613
0.031311
0.023483
0.035225
0.031311
0.043053
0.037182
1
2,804
T
G
A
A
C
T
G
A
T
A
G
A
A
A
A
G
T
A
T
T
T
T
G
T
G
T
C
C
C
C
T
A
C
C
C
T
G
T
T
C
C
G
A
G
T
G
A
T
C
C
G
T
C
T
T
G
C
C
A
G
G
A
T
T
G
A
0.076321
0.050881
0.039139
0.043053
0.062622
0.011742
0.011742
0.023483
0.029354
0.015656
0.037182
0.046967
0.046967
0.054795
0.054795
0.009785
0.033268
0.021526
0.019569
0.009785
0.009785
0.007828
0.019569
0.013699
0.035225
0.017613
0.031311
0.019569
0.035225
0.031311
0.043053
0.037182
1
2,805
A
C
T
G
A
T
A
G
A
A
A
A
G
T
A
T
T
T
T
G
T
G
T
C
C
C
C
T
A
C
C
C
T
G
T
T
C
C
G
A
G
T
G
A
T
C
C
G
T
C
T
T
G
C
C
A
G
G
A
T
T
G
G
C
C
C
0.076321
0.050881
0.037182
0.043053
0.062622
0.011742
0.011742
0.023483
0.029354
0.015656
0.035225
0.046967
0.046967
0.054795
0.056751
0.009785
0.033268
0.023483
0.017613
0.009785
0.009785
0.007828
0.019569
0.013699
0.035225
0.017613
0.031311
0.019569
0.037182
0.031311
0.043053
0.037182
1
2,806
G
G
A
T
T
C
G
G
C
C
A
A
T
C
C
T
G
G
C
A
A
G
A
C
G
G
A
T
C
A
C
T
C
G
G
A
A
C
A
G
G
G
T
A
G
G
G
G
A
C
A
C
A
A
A
A
T
A
C
T
T
T
T
C
T
T
0.078278
0.050881
0.037182
0.04501
0.064579
0.011742
0.011742
0.023483
0.029354
0.015656
0.035225
0.043053
0.04501
0.054795
0.056751
0.009785
0.033268
0.023483
0.017613
0.009785
0.009785
0.007828
0.019569
0.013699
0.035225
0.017613
0.031311
0.019569
0.037182
0.033268
0.041096
0.037182
1
2,807
A
T
T
T
T
G
T
G
T
C
C
C
C
T
A
C
C
C
T
G
T
T
C
C
G
A
G
T
G
A
T
C
C
G
T
C
T
T
G
C
C
A
G
G
A
T
T
G
G
C
C
G
A
A
T
C
C
T
A
C
G
T
C
T
G
G
0.076321
0.052838
0.035225
0.043053
0.064579
0.013699
0.011742
0.023483
0.029354
0.015656
0.037182
0.043053
0.04501
0.052838
0.058708
0.009785
0.035225
0.023483
0.017613
0.009785
0.009785
0.007828
0.019569
0.015656
0.033268
0.017613
0.033268
0.019569
0.037182
0.033268
0.039139
0.035225
1
2,808
T
C
A
G
A
C
G
T
A
G
G
A
T
T
C
G
G
C
C
A
A
T
C
C
T
G
G
C
A
A
G
A
C
G
G
A
T
C
A
C
T
C
G
G
A
A
C
A
G
G
G
T
A
G
G
G
G
A
C
A
C
A
A
A
A
A
0.076321
0.052838
0.035225
0.043053
0.064579
0.013699
0.011742
0.023483
0.029354
0.017613
0.037182
0.043053
0.04501
0.052838
0.058708
0.009785
0.035225
0.023483
0.017613
0.009785
0.009785
0.007828
0.019569
0.015656
0.033268
0.017613
0.033268
0.019569
0.037182
0.033268
0.037182
0.035225
1
2,809
C
C
T
T
T
G
C
T
C
C
T
T
T
G
A
T
C
A
G
A
C
G
T
A
G
G
A
T
T
C
G
G
C
C
A
A
T
C
C
T
G
G
C
A
A
G
A
C
G
G
A
T
C
A
C
T
C
G
G
A
A
C
A
G
G
T
0.072407
0.052838
0.033268
0.041096
0.062622
0.013699
0.011742
0.023483
0.027397
0.019569
0.037182
0.037182
0.046967
0.052838
0.060665
0.009785
0.039139
0.029354
0.019569
0.009785
0.009785
0.007828
0.019569
0.015656
0.033268
0.017613
0.033268
0.021526
0.041096
0.031311
0.033268
0.035225
1
2,810
C
C
T
T
T
G
C
T
C
C
T
T
T
G
A
T
C
A
G
A
C
G
T
A
G
G
A
T
T
C
G
G
C
C
A
A
T
C
C
T
G
G
C
A
A
G
A
C
G
G
A
T
C
A
C
T
C
G
G
A
A
C
A
G
G
A
0.072407
0.052838
0.033268
0.041096
0.062622
0.013699
0.011742
0.023483
0.027397
0.019569
0.037182
0.037182
0.046967
0.052838
0.060665
0.009785
0.039139
0.029354
0.019569
0.009785
0.009785
0.007828
0.019569
0.015656
0.033268
0.017613
0.033268
0.021526
0.041096
0.031311
0.033268
0.035225
1
2,811
G
C
G
T
G
C
G
G
A
T
C
C
C
C
T
T
T
G
C
T
C
C
T
T
T
G
A
T
C
A
G
A
C
G
T
A
G
G
A
T
T
C
G
G
C
C
A
A
T
C
C
T
G
G
C
A
A
G
A
C
G
G
A
T
C
G
0.072407
0.048924
0.033268
0.043053
0.058708
0.013699
0.011742
0.023483
0.027397
0.023483
0.039139
0.035225
0.046967
0.050881
0.060665
0.009785
0.039139
0.027397
0.019569
0.009785
0.009785
0.007828
0.02544
0.015656
0.033268
0.017613
0.037182
0.021526
0.041096
0.031311
0.029354
0.035225
1
2,812
C
A
T
C
A
T
C
A
A
A
G
C
A
A
A
G
A
G
C
A
G
C
G
T
G
C
G
G
A
T
C
C
C
C
T
T
T
G
C
T
C
C
T
T
T
G
A
T
C
A
G
A
C
G
T
A
G
G
A
T
T
C
G
G
C
T
0.064579
0.04501
0.035225
0.043053
0.056751
0.013699
0.011742
0.023483
0.031311
0.023483
0.041096
0.035225
0.046967
0.046967
0.056751
0.011742
0.039139
0.029354
0.019569
0.009785
0.009785
0.007828
0.027397
0.017613
0.033268
0.019569
0.037182
0.021526
0.04501
0.029354
0.033268
0.033268
1
2,813
T
G
A
T
C
A
A
A
G
G
A
G
C
A
A
A
G
G
G
G
A
T
C
C
G
C
A
C
G
C
T
G
C
T
C
T
T
T
G
C
T
T
T
G
A
T
G
A
T
G
T
C
C
C
T
T
C
C
T
G
C
G
T
T
G
A
0.062622
0.041096
0.035225
0.041096
0.056751
0.015656
0.011742
0.02544
0.031311
0.021526
0.043053
0.035225
0.046967
0.04501
0.052838
0.013699
0.043053
0.029354
0.021526
0.009785
0.009785
0.007828
0.027397
0.015656
0.033268
0.02544
0.033268
0.021526
0.04501
0.029354
0.033268
0.035225
1
2,814
G
A
T
C
A
A
A
G
G
A
G
C
A
A
A
G
G
G
G
A
T
C
C
G
C
A
C
G
C
T
G
C
T
C
T
T
T
G
C
T
T
T
G
A
T
G
A
T
G
T
C
C
C
T
T
C
C
T
G
C
G
T
T
G
T
C
0.064579
0.041096
0.035225
0.041096
0.056751
0.015656
0.011742
0.02544
0.031311
0.021526
0.043053
0.035225
0.046967
0.04501
0.052838
0.013699
0.043053
0.029354
0.021526
0.009785
0.009785
0.007828
0.027397
0.015656
0.033268
0.02544
0.031311
0.021526
0.04501
0.029354
0.033268
0.035225
1
2,815
G
T
T
A
A
A
C
A
A
C
G
C
A
G
G
A
A
G
G
G
A
C
A
T
C
A
T
C
A
A
A
G
C
A
A
A
G
A
G
C
A
G
C
G
T
G
C
G
G
A
T
C
C
C
C
T
T
T
G
C
T
C
C
T
T
G
0.064579
0.041096
0.037182
0.039139
0.056751
0.015656
0.011742
0.02544
0.031311
0.021526
0.043053
0.035225
0.048924
0.04501
0.052838
0.013699
0.041096
0.029354
0.021526
0.009785
0.009785
0.007828
0.027397
0.015656
0.033268
0.02544
0.031311
0.021526
0.04501
0.029354
0.031311
0.037182
1
2,816
G
A
T
C
C
G
C
A
C
G
C
T
G
C
T
C
T
T
T
G
C
T
T
T
G
A
T
G
A
T
G
T
C
C
C
T
T
C
C
T
G
C
G
T
T
G
T
T
T
A
A
C
A
T
C
G
G
C
C
T
C
C
T
T
C
T
0.062622
0.041096
0.039139
0.037182
0.056751
0.017613
0.011742
0.02544
0.031311
0.02544
0.04501
0.023483
0.048924
0.043053
0.050881
0.015656
0.043053
0.031311
0.023483
0.009785
0.009785
0.007828
0.027397
0.017613
0.035225
0.02544
0.027397
0.021526
0.046967
0.027397
0.031311
0.039139
1
2,817
T
C
C
G
C
A
C
G
C
T
G
C
T
C
T
T
T
G
C
T
T
T
G
A
T
G
A
T
G
T
C
C
C
T
T
C
C
T
G
C
G
T
T
G
T
T
T
A
A
C
A
T
C
G
G
C
C
T
C
C
T
T
C
T
T
T
0.062622
0.041096
0.039139
0.037182
0.054795
0.017613
0.011742
0.027397
0.031311
0.02544
0.04501
0.023483
0.048924
0.041096
0.050881
0.015656
0.04501
0.031311
0.023483
0.009785
0.009785
0.007828
0.027397
0.017613
0.035225
0.02544
0.027397
0.021526
0.046967
0.027397
0.031311
0.039139
1
2,818
T
A
T
T
A
A
G
A
A
T
A
G
G
T
G
C
T
A
G
C
A
A
T
C
C
A
T
C
C
C
A
G
C
C
A
G
C
A
G
A
G
G
T
T
G
T
A
A
T
T
T
G
G
A
A
C
A
G
G
C
A
G
A
T
C
A
0.04501
0.039139
0.04501
0.019569
0.04501
0.021526
0.009785
0.02544
0.041096
0.02544
0.046967
0.011742
0.058708
0.050881
0.046967
0.021526
0.048924
0.041096
0.023483
0.007828
0.009785
0.011742
0.017613
0.031311
0.037182
0.027397
0.031311
0.021526
0.052838
0.013699
0.019569
0.050881
1
2,819
C
A
A
A
A
A
A
G
A
A
A
A
T
C
C
C
A
A
C
A
G
A
T
G
G
G
T
T
C
C
C
A
C
A
G
T
C
T
C
C
T
T
T
A
A
C
T
G
A
G
C
T
T
C
C
A
G
G
G
T
G
A
T
C
T
T
0.052838
0.04501
0.039139
0.017613
0.041096
0.02544
0.001957
0.033268
0.048924
0.017613
0.043053
0.017613
0.056751
0.052838
0.043053
0.019569
0.048924
0.04501
0.02544
0.005871
0.011742
0.007828
0.017613
0.037182
0.039139
0.02544
0.029354
0.019569
0.048924
0.011742
0.021526
0.048924
1
2,820
C
A
C
C
A
C
A
A
C
C
A
G
G
A
A
G
G
A
T
A
T
G
A
T
G
A
T
G
T
A
A
C
T
G
A
C
A
A
A
A
A
A
G
A
A
A
A
T
C
C
C
A
A
C
A
G
A
T
G
G
G
T
T
C
C
G
0.052838
0.04501
0.037182
0.019569
0.039139
0.02544
0.001957
0.035225
0.046967
0.023483
0.037182
0.017613
0.054795
0.052838
0.050881
0.019569
0.048924
0.050881
0.027397
0.003914
0.009785
0.007828
0.019569
0.037182
0.033268
0.02544
0.033268
0.017613
0.048924
0.011742
0.017613
0.046967
1
2,821
A
C
T
G
A
A
G
T
T
C
T
C
C
A
G
G
A
T
G
A
C
C
G
C
G
A
T
G
T
A
C
A
T
G
T
T
C
A
C
C
A
C
A
A
C
C
A
G
G
A
A
G
G
A
T
A
T
G
A
T
G
A
T
G
T
A
0.046967
0.04501
0.035225
0.015656
0.039139
0.031311
0
0.039139
0.046967
0.023483
0.035225
0.015656
0.056751
0.048924
0.04501
0.027397
0.052838
0.052838
0.027397
0.007828
0.009785
0.005871
0.015656
0.039139
0.033268
0.027397
0.033268
0.015656
0.048924
0.009785
0.017613
0.050881
1
2,822
A
T
C
C
T
T
C
C
T
G
G
T
T
G
T
G
G
T
G
A
A
C
A
T
G
T
A
C
A
T
C
G
C
G
G
T
C
A
T
C
C
T
G
G
A
G
A
A
C
T
T
C
A
G
T
G
T
T
G
C
T
A
C
T
G
A
0.046967
0.043053
0.037182
0.015656
0.039139
0.031311
0
0.039139
0.046967
0.023483
0.033268
0.015656
0.058708
0.050881
0.046967
0.027397
0.052838
0.052838
0.02544
0.007828
0.009785
0.005871
0.015656
0.037182
0.033268
0.029354
0.033268
0.015656
0.046967
0.009785
0.015656
0.052838
1
2,823
A
G
G
T
T
T
G
G
G
A
G
A
A
G
T
T
T
G
A
T
C
C
C
G
A
T
G
C
G
A
C
C
C
A
G
T
T
T
A
T
A
G
A
G
T
T
T
G
C
C
A
A
A
C
T
T
T
C
T
G
A
T
T
T
T
G
0.056751
0.035225
0.041096
0.011742
0.035225
0.029354
0.001957
0.039139
0.052838
0.021526
0.029354
0.017613
0.054795
0.054795
0.041096
0.031311
0.043053
0.054795
0.031311
0.007828
0.011742
0.009785
0.009785
0.048924
0.033268
0.027397
0.027397
0.015656
0.046967
0.011742
0.013699
0.052838
1
2,824
G
C
T
T
T
G
T
A
A
A
A
G
C
A
A
A
T
A
A
G
A
T
G
T
C
A
A
G
A
C
A
G
T
G
G
A
T
C
C
G
G
T
C
A
C
C
A
C
T
C
A
C
C
A
T
G
G
G
C
A
G
A
T
C
C
C
0.062622
0.033268
0.050881
0.015656
0.031311
0.02544
0.011742
0.033268
0.056751
0.02544
0.029354
0.029354
0.04501
0.046967
0.050881
0.02544
0.031311
0.043053
0.023483
0.007828
0.013699
0.013699
0.011742
0.050881
0.031311
0.023483
0.035225
0.019569
0.035225
0.021526
0.019569
0.04501
1
2,825
A
C
T
T
T
G
G
A
G
G
G
G
T
T
T
G
A
T
G
C
C
A
T
G
A
A
T
C
G
C
T
C
T
T
C
C
A
T
C
T
G
T
A
T
T
C
G
A
A
G
G
G
C
A
T
C
C
A
T
C
T
C
T
C
C
G
0.066536
0.035225
0.048924
0.02544
0.027397
0.027397
0.011742
0.027397
0.062622
0.021526
0.023483
0.037182
0.048924
0.048924
0.054795
0.021526
0.02544
0.046967
0.02544
0.007828
0.013699
0.009785
0.009785
0.050881
0.035225
0.019569
0.029354
0.017613
0.033268
0.017613
0.021526
0.046967
1
2,826
A
G
A
T
G
G
A
T
G
C
C
C
T
T
C
G
A
A
T
A
C
A
G
A
T
G
G
A
A
G
A
G
C
G
A
T
T
C
A
T
G
G
C
A
T
C
A
A
A
C
C
C
C
T
C
C
A
A
A
G
T
C
T
C
T
G
0.066536
0.035225
0.048924
0.02544
0.027397
0.027397
0.013699
0.027397
0.060665
0.021526
0.023483
0.037182
0.048924
0.048924
0.052838
0.021526
0.02544
0.046967
0.02544
0.007828
0.013699
0.011742
0.009785
0.048924
0.035225
0.021526
0.029354
0.019569
0.033268
0.017613
0.021526
0.04501
1
2,827
A
A
G
A
G
A
C
T
T
T
G
G
A
G
G
G
G
T
T
T
G
A
T
G
C
C
A
T
G
A
A
T
C
G
C
T
C
T
T
C
C
A
T
C
T
G
T
A
T
T
C
G
A
A
G
G
G
C
A
T
C
C
A
T
C
A
0.066536
0.035225
0.048924
0.02544
0.027397
0.027397
0.013699
0.027397
0.060665
0.021526
0.02544
0.037182
0.046967
0.048924
0.052838
0.021526
0.02544
0.046967
0.02544
0.007828
0.013699
0.011742
0.009785
0.048924
0.035225
0.021526
0.029354
0.019569
0.033268
0.017613
0.021526
0.04501
1
2,828
A
T
G
C
T
G
C
T
C
A
A
G
G
T
C
T
C
G
T
T
C
A
G
C
T
G
A
A
G
G
C
A
T
G
T
A
C
C
T
A
C
A
A
A
G
G
T
C
A
C
A
A
G
A
C
A
G
T
T
G
T
C
A
C
T
G
0.072407
0.037182
0.039139
0.072407
0.04501
0.015656
0.003914
0.039139
0.046967
0.029354
0.017613
0.068493
0.023483
0.04501
0.039139
0.019569
0.033268
0.019569
0.009785
0.001957
0.005871
0
0.029354
0.033268
0.04501
0.013699
0.029354
0.003914
0.019569
0.033268
0.064579
0.043053
1
2,829
A
A
C
A
A
A
A
T
T
T
G
A
C
A
A
T
G
G
A
T
T
A
T
T
T
T
T
C
A
G
A
A
C
A
C
C
C
A
C
T
T
T
T
G
C
A
G
G
A
G
G
A
C
T
T
T
T
T
T
C
C
A
T
A
T
A
0.131115
0.027397
0.046967
0.078278
0.033268
0.009785
0.003914
0.035225
0.041096
0.023483
0.009785
0.07045
0.029354
0.039139
0.037182
0.019569
0.023483
0.029354
0.019569
0.003914
0.007828
0
0.019569
0.019569
0.050881
0.013699
0.019569
0.003914
0.029354
0.021526
0.064579
0.037182
1
2,830
G
T
T
G
C
T
A
G
G
A
G
C
A
A
C
A
G
T
C
G
C
A
A
C
A
G
C
T
G
A
A
A
C
G
C
T
C
A
C
A
T
T
T
T
T
A
G
A
T
G
C
T
C
A
C
T
G
T
A
A
G
T
A
T
A
A
0.099804
0.037182
0.048924
0.054795
0.043053
0.013699
0.003914
0.031311
0.046967
0.035225
0.031311
0.048924
0.023483
0.04501
0.029354
0.015656
0.037182
0.015656
0.009785
0.001957
0.005871
0.007828
0.029354
0.029354
0.052838
0.013699
0.033268
0.005871
0.029354
0.023483
0.058708
0.037182
1
2,831
A
A
C
T
G
G
A
C
A
A
A
A
G
A
A
T
T
A
T
C
T
T
T
G
C
T
A
T
G
A
C
C
T
G
G
C
T
G
A
G
C
T
C
T
T
A
T
T
A
A
A
A
T
T
G
A
A
A
T
G
G
T
A
T
G
C
0.09589
0.02544
0.039139
0.078278
0.033268
0.019569
0.001957
0.027397
0.048924
0.029354
0.017613
0.078278
0.021526
0.056751
0.039139
0.011742
0.037182
0.027397
0.001957
0
0
0.001957
0.02544
0.023483
0.050881
0.015656
0.031311
0.015656
0.009785
0.029354
0.052838
0.052838
1
2,832
C
T
T
G
T
T
T
T
A
C
A
G
T
T
C
G
C
T
T
T
A
A
A
A
G
G
T
G
G
C
G
T
C
T
G
T
A
A
G
C
A
C
G
C
T
G
A
A
T
A
A
T
G
A
C
A
G
C
A
G
A
T
A
C
T
G
0.088063
0.023483
0.058708
0.041096
0.039139
0.023483
0.011742
0.023483
0.046967
0.039139
0.023483
0.029354
0.037182
0.041096
0.046967
0.027397
0.029354
0.046967
0.011742
0.009785
0.007828
0.009785
0.017613
0.027397
0.043053
0.023483
0.019569
0.017613
0.037182
0.023483
0.035225
0.039139
1
2,833
G
T
T
C
G
C
T
T
T
A
A
A
A
G
G
T
G
G
C
G
T
C
T
G
T
A
A
G
C
A
C
G
C
T
G
A
A
T
A
A
T
G
A
C
A
G
C
A
G
A
T
A
C
T
T
C
C
T
C
T
T
G
T
T
T
A
0.082192
0.023483
0.058708
0.039139
0.039139
0.023483
0.011742
0.023483
0.050881
0.039139
0.023483
0.027397
0.039139
0.039139
0.048924
0.027397
0.031311
0.046967
0.011742
0.009785
0.007828
0.009785
0.017613
0.031311
0.039139
0.023483
0.021526
0.019569
0.037182
0.023483
0.033268
0.039139
1
2,834
A
C
G
A
A
A
A
C
A
A
G
A
G
G
A
A
G
T
A
T
C
T
G
C
T
G
T
C
A
T
T
A
T
T
C
A
G
C
G
T
G
C
T
T
A
C
A
G
A
C
G
C
C
A
C
C
T
T
T
T
A
A
A
G
C
G
0.082192
0.023483
0.056751
0.039139
0.039139
0.023483
0.011742
0.023483
0.050881
0.039139
0.023483
0.027397
0.039139
0.039139
0.048924
0.027397
0.031311
0.046967
0.009785
0.011742
0.007828
0.011742
0.017613
0.031311
0.039139
0.023483
0.021526
0.021526
0.035225
0.023483
0.033268
0.039139
1
2,835
C
A
A
A
C
T
C
C
A
G
C
T
C
A
T
T
G
C
C
A
T
G
G
A
T
T
T
G
C
C
C
A
T
G
G
T
G
A
G
T
G
G
T
G
A
C
C
G
G
A
T
C
C
A
C
T
G
T
C
T
T
G
A
T
A
G
0.052838
0.037182
0.046967
0.027397
0.031311
0.023483
0.009785
0.037182
0.046967
0.037182
0.027397
0.021526
0.046967
0.043053
0.04501
0.027397
0.039139
0.043053
0.007828
0.011742
0.011742
0.019569
0.015656
0.046967
0.04501
0.013699
0.029354
0.015656
0.043053
0.023483
0.021526
0.050881
1
2,836
C
A
A
A
C
T
C
C
A
G
C
T
C
A
T
T
G
C
C
A
T
G
G
A
T
T
T
G
C
C
C
A
T
G
G
T
G
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G
T
G
G
T
G
A
C
C
G
G
A
T
C
C
A
C
T
G
T
C
T
T
G
A
T
A
A
0.052838
0.037182
0.046967
0.027397
0.031311
0.023483
0.009785
0.037182
0.046967
0.037182
0.027397
0.021526
0.046967
0.043053
0.04501
0.027397
0.039139
0.043053
0.007828
0.011742
0.011742
0.019569
0.015656
0.046967
0.04501
0.013699
0.029354
0.015656
0.043053
0.023483
0.021526
0.050881
1
2,837
A
A
A
C
A
A
A
C
T
C
C
A
G
C
T
C
A
T
T
G
C
C
A
T
G
G
A
T
T
T
G
C
C
C
A
T
G
G
T
G
A
G
T
G
G
T
G
A
C
C
G
G
A
T
C
C
A
C
T
G
T
C
T
T
G
A
0.052838
0.037182
0.046967
0.027397
0.031311
0.023483
0.007828
0.037182
0.046967
0.037182
0.027397
0.021526
0.048924
0.04501
0.04501
0.027397
0.039139
0.043053
0.007828
0.011742
0.011742
0.019569
0.015656
0.046967
0.04501
0.013699
0.029354
0.015656
0.043053
0.021526
0.019569
0.052838
1
2,838
G
C
C
A
C
A
A
C
C
A
A
A
C
A
A
A
C
T
C
C
A
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C
T
C
A
T
T
G
C
C
A
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G
A
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C
C
C
A
T
G
G
T
G
A
G
T
G
G
T
G
A
C
C
G
G
A
T
C
C
C
0.050881
0.039139
0.041096
0.027397
0.033268
0.023483
0.007828
0.039139
0.046967
0.033268
0.02544
0.021526
0.048924
0.046967
0.04501
0.027397
0.041096
0.043053
0.007828
0.011742
0.011742
0.019569
0.015656
0.046967
0.043053
0.015656
0.029354
0.015656
0.041096
0.023483
0.021526
0.054795
1
2,839
T
A
T
C
T
C
A
G
T
T
T
G
C
A
G
C
T
G
C
G
C
T
T
G
A
A
C
C
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C
C
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A
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G
C
C
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C
A
A
C
C
A
A
A
C
A
A
A
C
T
C
C
A
G
C
T
C
G
0.052838
0.039139
0.037182
0.031311
0.033268
0.023483
0.003914
0.039139
0.050881
0.029354
0.023483
0.021526
0.050881
0.048924
0.046967
0.02544
0.041096
0.046967
0.013699
0.011742
0.009785
0.015656
0.015656
0.048924
0.046967
0.015656
0.027397
0.013699
0.046967
0.019569
0.013699
0.054795
1
2,840
T
C
A
G
T
T
C
A
T
G
G
A
A
T
T
T
G
A
A
A
A
A
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C
T
C
A
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T
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C
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C
T
G
C
G
C
T
T
G
A
A
C
C
G
C
C
T
C
T
C
A
A
T
C
T
G
C
G
0.052838
0.04501
0.039139
0.027397
0.031311
0.02544
0.003914
0.039139
0.048924
0.029354
0.027397
0.017613
0.048924
0.046967
0.046967
0.02544
0.039139
0.048924
0.015656
0.011742
0.009785
0.013699
0.015656
0.050881
0.046967
0.013699
0.02544
0.013699
0.048924
0.017613
0.019569
0.052838
1
2,841
C
T
T
T
G
A
G
A
T
G
T
T
C
T
A
T
G
A
G
G
T
T
T
G
G
G
A
G
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A
G
T
T
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A
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C
C
C
G
A
T
G
C
A
A
C
T
C
A
G
T
T
C
A
T
G
G
A
A
T
T
T
G
C
0.04501
0.043053
0.039139
0.029354
0.033268
0.029354
0.001957
0.039139
0.046967
0.031311
0.023483
0.017613
0.04501
0.048924
0.04501
0.029354
0.041096
0.050881
0.021526
0.013699
0.009785
0.013699
0.015656
0.048924
0.04501
0.015656
0.027397
0.013699
0.04501
0.015656
0.021526
0.052838
1
2,842
C
A
G
A
G
C
C
T
C
T
G
A
G
T
G
A
G
G
A
T
G
A
C
T
T
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G
A
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C
T
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G
G
G
A
G
A
A
G
T
T
T
G
A
T
C
C
C
G
A
T
C
0.04501
0.043053
0.033268
0.029354
0.033268
0.029354
0.001957
0.039139
0.048924
0.035225
0.021526
0.017613
0.046967
0.046967
0.043053
0.029354
0.046967
0.050881
0.023483
0.013699
0.009785
0.013699
0.015656
0.050881
0.039139
0.015656
0.031311
0.013699
0.043053
0.015656
0.021526
0.050881
1
2,843
C
T
G
G
A
G
A
A
C
T
T
C
A
G
T
G
T
T
G
C
T
A
C
T
G
A
A
G
A
A
A
G
T
G
C
A
G
A
G
C
C
T
C
T
G
A
G
T
G
A
G
G
A
T
G
A
C
T
T
T
G
A
G
A
T
A
0.046967
0.046967
0.031311
0.031311
0.035225
0.031311
0
0.039139
0.04501
0.033268
0.02544
0.017613
0.043053
0.04501
0.048924
0.029354
0.048924
0.048924
0.023483
0.013699
0.005871
0.011742
0.015656
0.046967
0.037182
0.015656
0.035225
0.015656
0.041096
0.013699
0.023483
0.052838
1
2,844
C
T
C
A
C
T
C
A
G
A
G
G
C
T
C
T
G
C
A
C
T
T
T
C
T
T
C
A
G
T
A
G
C
A
A
C
A
C
T
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A
A
G
T
T
C
T
C
C
A
G
G
A
T
G
A
C
C
G
C
G
A
T
G
T
T
0.050881
0.046967
0.035225
0.031311
0.035225
0.033268
0
0.037182
0.039139
0.033268
0.027397
0.017613
0.043053
0.04501
0.052838
0.027397
0.048924
0.048924
0.023483
0.013699
0.005871
0.011742
0.015656
0.039139
0.037182
0.017613
0.035225
0.017613
0.037182
0.013699
0.023483
0.054795
1
2,845
A
T
C
C
T
T
C
C
T
G
G
T
T
G
T
G
G
T
G
A
A
C
A
T
G
T
A
C
A
T
C
G
C
G
G
T
C
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C
C
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G
A
G
A
A
C
T
T
C
A
G
T
G
T
T
G
C
T
A
C
T
G
T
0.043053
0.050881
0.033268
0.029354
0.037182
0.031311
0
0.041096
0.037182
0.029354
0.02544
0.015656
0.048924
0.050881
0.052838
0.027397
0.048924
0.050881
0.023483
0.011742
0.009785
0.009785
0.011742
0.039139
0.039139
0.019569
0.033268
0.017613
0.039139
0.011742
0.021526
0.058708
1
2,846
A
G
T
A
G
C
A
A
C
A
C
T
G
A
A
G
T
T
C
T
C
C
A
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G
A
T
G
A
C
C
G
C
G
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C
A
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T
T
C
A
C
C
A
C
A
A
C
C
A
G
G
A
A
G
G
A
T
A
T
0.043053
0.050881
0.033268
0.029354
0.037182
0.031311
0
0.041096
0.037182
0.029354
0.02544
0.015656
0.048924
0.050881
0.052838
0.027397
0.048924
0.050881
0.023483
0.011742
0.009785
0.009785
0.011742
0.039139
0.039139
0.019569
0.033268
0.017613
0.041096
0.011742
0.019569
0.058708
1