row_idx
int64
f_0_ref__32
string
f_1_ref__31
string
f_2_ref__30
string
f_3_ref__29
string
f_4_ref__28
string
f_5_ref__27
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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f_64_ref__32
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f_65_alt
string
f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
3,847
A
G
G
C
C
C
G
G
G
A
T
T
T
C
C
T
T
T
A
T
C
T
C
C
T
T
G
T
T
C
C
C
C
C
T
T
G
G
C
T
C
C
T
G
G
G
G
T
T
C
C
T
C
T
C
T
G
G
C
C
C
T
T
T
A
T
0.054795
0.043053
0.039139
0.039139
0.039139
0.02544
0.005871
0.029354
0.031311
0.027397
0.068493
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0.011742
0.037182
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0.060665
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0.009785
0
0
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0.033268
0.041096
0.015656
0.017613
0.041096
0.048924
0.019569
0.04501
0.039139
1
3,848
G
T
T
G
C
C
C
C
A
T
T
T
C
T
C
C
T
T
T
C
T
T
T
C
C
C
A
T
A
T
C
A
C
C
C
G
G
C
A
G
T
C
C
T
G
G
A
T
C
C
C
C
C
T
T
A
A
A
T
G
T
A
G
T
C
T
0.080235
0.021526
0.046967
0.058708
0.021526
0.019569
0.001957
0.039139
0.023483
0.033268
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0.046967
0.017613
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0.027397
0.02544
0.052838
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0.005871
0
0
0.019569
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0.050881
0.015656
0.037182
0.031311
0.035225
0.019569
0.050881
0.043053
1
3,849
T
G
G
G
C
C
A
G
G
T
T
G
C
C
C
C
A
T
T
T
C
T
C
C
T
T
T
C
T
T
T
C
C
C
A
T
A
T
C
A
C
C
C
G
G
C
A
G
T
C
C
T
G
G
A
T
C
C
C
C
C
T
T
A
A
T
0.080235
0.021526
0.04501
0.062622
0.019569
0.019569
0.001957
0.039139
0.02544
0.031311
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0.046967
0.017613
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0.005871
0
0
0.019569
0.019569
0.054795
0.013699
0.035225
0.031311
0.035225
0.019569
0.050881
0.04501
1
3,850
C
A
G
G
T
C
C
A
G
C
A
G
G
C
C
C
C
A
A
A
T
G
T
C
C
A
G
G
T
G
G
G
C
C
A
G
G
T
T
G
C
C
C
C
A
T
T
T
C
T
C
C
T
T
T
C
T
T
T
C
C
C
A
T
A
T
0.07045
0.019569
0.041096
0.066536
0.019569
0.019569
0.001957
0.037182
0.029354
0.035225
0.037182
0.046967
0.019569
0.039139
0.02544
0.023483
0.052838
0.043053
0.039139
0.005871
0
0
0.021526
0.023483
0.050881
0.013699
0.035225
0.033268
0.033268
0.021526
0.050881
0.043053
1
3,851
A
A
A
G
A
G
A
A
A
G
T
A
C
A
A
A
A
A
T
G
A
A
A
C
C
T
G
G
A
G
G
G
C
C
T
C
T
G
A
T
T
C
C
T
G
G
A
G
G
G
C
C
C
A
G
G
A
G
G
C
C
T
T
T
G
T
0.103718
0.031311
0.033268
0.046967
0.027397
0.031311
0.003914
0.023483
0.04501
0.019569
0.054795
0.035225
0.031311
0.035225
0.035225
0.017613
0.043053
0.043053
0.02544
0.001957
0
0.001957
0.027397
0.039139
0.046967
0.015656
0.019569
0.021526
0.046967
0.021526
0.029354
0.041096
1
3,852
C
T
G
G
A
C
C
A
G
G
A
A
T
T
C
C
A
T
C
A
C
G
T
C
C
T
T
G
G
T
C
A
C
C
T
C
T
T
A
T
A
C
C
C
A
T
T
G
G
T
C
C
A
G
G
A
G
A
T
C
C
T
G
G
A
T
0.101761
0.039139
0.029354
0.056751
0.043053
0.027397
0.007828
0.023483
0.04501
0.017613
0.029354
0.048924
0.043053
0.039139
0.031311
0.021526
0.037182
0.04501
0.019569
0.009785
0.001957
0
0.027397
0.023483
0.043053
0.013699
0.009785
0.011742
0.04501
0.027397
0.048924
0.031311
1
3,853
T
G
A
G
C
A
A
G
T
T
G
T
A
C
C
C
G
T
T
T
C
T
C
C
C
T
T
T
T
C
T
C
C
G
G
C
T
G
G
A
C
C
A
G
G
A
A
T
T
C
C
A
T
C
A
C
G
T
C
C
T
T
G
G
T
T
0.101761
0.039139
0.031311
0.050881
0.043053
0.029354
0.007828
0.019569
0.046967
0.017613
0.037182
0.043053
0.035225
0.035225
0.033268
0.021526
0.039139
0.046967
0.029354
0.009785
0.001957
0
0.023483
0.027397
0.043053
0.013699
0.009785
0.019569
0.043053
0.02544
0.04501
0.029354
1
3,854
A
T
G
A
G
C
A
A
G
T
T
G
T
A
C
C
C
G
T
T
T
C
T
C
C
C
T
T
T
T
C
T
C
C
G
G
C
T
G
G
A
C
C
A
G
G
A
A
T
T
C
C
A
T
C
A
C
G
T
C
C
T
T
G
G
T
0.101761
0.039139
0.031311
0.050881
0.043053
0.029354
0.007828
0.019569
0.04501
0.017613
0.037182
0.043053
0.035225
0.035225
0.033268
0.021526
0.039139
0.046967
0.029354
0.009785
0.001957
0
0.023483
0.027397
0.043053
0.013699
0.009785
0.019569
0.04501
0.02544
0.04501
0.029354
1
3,855
G
G
G
T
C
C
T
C
G
A
G
G
T
C
C
A
G
C
A
T
C
T
C
C
C
A
T
G
G
C
C
C
C
T
T
T
T
C
T
G
C
C
C
G
G
G
A
G
G
C
C
A
G
G
A
A
A
A
C
C
T
G
G
G
G
T
0.074364
0.031311
0.046967
0.037182
0.027397
0.033268
0.001957
0.021526
0.04501
0.02544
0.052838
0.054795
0.015656
0.033268
0.035225
0.013699
0.04501
0.04501
0.043053
0.007828
0.005871
0
0.013699
0.039139
0.037182
0.023483
0.031311
0.033268
0.039139
0.015656
0.04501
0.02544
1
3,856
G
G
G
T
C
C
T
C
G
A
G
G
T
C
C
A
G
C
A
T
C
T
C
C
C
A
T
G
G
C
C
C
C
T
T
T
T
C
T
G
C
C
C
G
G
G
A
G
G
C
C
A
G
G
A
A
A
A
C
C
T
G
G
G
G
G
0.074364
0.031311
0.046967
0.037182
0.027397
0.033268
0.001957
0.021526
0.04501
0.02544
0.052838
0.054795
0.015656
0.033268
0.035225
0.013699
0.04501
0.04501
0.043053
0.007828
0.005871
0
0.013699
0.039139
0.037182
0.023483
0.031311
0.033268
0.039139
0.015656
0.04501
0.02544
1
3,857
T
G
G
G
T
C
C
T
C
G
A
G
G
T
C
C
A
G
C
A
T
C
T
C
C
C
A
T
G
G
C
C
C
C
T
T
T
T
C
T
G
C
C
C
G
G
G
A
G
G
C
C
A
G
G
A
A
A
A
C
C
T
G
G
G
T
0.074364
0.031311
0.046967
0.037182
0.027397
0.033268
0.001957
0.021526
0.04501
0.02544
0.052838
0.054795
0.015656
0.033268
0.033268
0.015656
0.04501
0.04501
0.043053
0.007828
0.005871
0
0.013699
0.039139
0.037182
0.023483
0.031311
0.033268
0.039139
0.015656
0.04501
0.02544
1
3,858
T
A
T
T
T
T
A
T
G
C
T
G
T
T
T
A
A
A
A
G
T
A
A
A
C
C
C
T
T
T
A
C
C
T
G
G
G
C
T
T
C
C
T
C
T
T
G
A
G
C
C
T
G
G
T
G
G
A
C
C
A
C
G
A
T
T
0.056751
0.033268
0.046967
0.02544
0.02544
0.041096
0.007828
0.019569
0.031311
0.029354
0.064579
0.021526
0.017613
0.033268
0.035225
0.023483
0.048924
0.058708
0.052838
0.009785
0.007828
0.001957
0.013699
0.035225
0.031311
0.021526
0.035225
0.046967
0.04501
0.015656
0.041096
0.021526
1
3,859
A
T
T
T
A
C
C
A
G
G
T
G
G
T
C
C
T
T
T
T
G
G
C
C
C
A
A
T
T
G
G
T
C
C
T
G
G
A
G
G
T
C
C
A
A
T
G
G
A
T
C
C
T
A
G
A
A
A
T
C
C
A
G
G
A
T
0.043053
0.029354
0.037182
0.033268
0.048924
0.04501
0.009785
0.023483
0.037182
0.011742
0.066536
0.015656
0.029354
0.035225
0.033268
0.04501
0.048924
0.062622
0.031311
0.001957
0
0
0.031311
0.021526
0.037182
0.033268
0.017613
0.035225
0.050881
0.019569
0.031311
0.033268
1
3,860
A
A
G
C
T
G
G
G
G
G
T
T
T
A
C
C
T
G
G
C
T
C
T
C
C
T
T
T
A
G
A
A
C
C
T
T
T
G
T
T
G
C
C
T
T
T
T
T
C
T
C
C
A
G
C
T
G
G
T
C
C
A
G
G
A
A
0.058708
0.04501
0.046967
0.02544
0.029354
0.033268
0.001957
0.033268
0.035225
0.027397
0.056751
0.027397
0.035225
0.033268
0.043053
0.019569
0.04501
0.050881
0.02544
0.005871
0.011742
0
0.029354
0.029354
0.04501
0.023483
0.021526
0.033268
0.046967
0.011742
0.029354
0.039139
1
3,861
A
C
A
C
A
G
T
C
A
A
A
C
C
A
C
A
G
C
A
A
T
T
C
C
T
T
C
A
T
G
T
C
C
A
G
A
G
G
G
G
A
C
A
G
T
G
C
C
A
C
T
C
T
A
C
A
G
T
G
G
G
T
T
T
T
T
0.091977
0.037182
0.039139
0.046967
0.058708
0.019569
0.011742
0.031311
0.043053
0.021526
0.033268
0.031311
0.02544
0.029354
0.048924
0.033268
0.043053
0.039139
0.017613
0.003914
0.007828
0
0.017613
0.029354
0.037182
0.027397
0.027397
0.017613
0.039139
0.021526
0.039139
0.029354
1
3,862
G
A
A
T
G
G
C
A
T
T
G
T
G
G
T
A
A
A
T
C
G
C
T
G
C
A
G
G
C
A
G
C
T
G
C
C
A
A
G
A
G
T
T
C
C
T
A
A
T
G
A
A
A
C
A
T
C
A
G
A
C
T
G
A
G
A
0.072407
0.02544
0.04501
0.062622
0.037182
0.013699
0.001957
0.037182
0.041096
0.035225
0.021526
0.031311
0.037182
0.048924
0.043053
0.019569
0.046967
0.033268
0.013699
0.003914
0.011742
0.001957
0.021526
0.023483
0.043053
0.013699
0.04501
0.023483
0.021526
0.031311
0.048924
0.043053
1
3,863
T
T
T
G
T
T
T
T
T
C
T
C
C
A
G
T
T
T
T
T
A
G
T
T
T
A
T
G
G
G
A
G
C
T
A
T
T
T
T
G
C
A
G
T
A
A
T
T
G
C
T
G
G
A
A
T
T
T
T
C
C
T
A
A
T
G
0.066536
0.041096
0.041096
0.052838
0.035225
0.031311
0.003914
0.033268
0.043053
0.02544
0.02544
0.056751
0.033268
0.050881
0.056751
0.015656
0.02544
0.041096
0.019569
0.001957
0.001957
0.003914
0.023483
0.037182
0.023483
0.017613
0.029354
0.011742
0.02544
0.029354
0.054795
0.041096
1
3,864
G
T
T
G
A
G
C
C
C
T
C
T
C
T
G
A
T
C
T
A
C
T
A
C
A
A
T
C
A
C
A
G
T
C
A
T
G
A
T
G
G
T
C
T
G
A
A
T
C
A
C
C
A
A
G
G
C
A
A
T
A
A
A
G
G
C
0.062622
0.035225
0.048924
0.066536
0.039139
0.031311
0.001957
0.031311
0.04501
0.023483
0.035225
0.052838
0.027397
0.037182
0.054795
0.019569
0.035225
0.035225
0.007828
0
0
0.001957
0.023483
0.027397
0.039139
0.017613
0.031311
0.013699
0.02544
0.029354
0.058708
0.041096
1
3,865
A
G
A
T
T
C
T
T
C
C
A
T
C
T
A
T
A
A
T
G
G
G
G
C
C
G
T
A
G
A
A
G
C
T
A
T
T
G
C
A
A
C
C
T
T
T
G
G
A
G
G
T
A
A
G
C
A
A
A
T
G
T
C
A
C
T
0.052838
0.029354
0.056751
0.035225
0.023483
0.029354
0.017613
0.031311
0.029354
0.046967
0.037182
0.017613
0.023483
0.033268
0.035225
0.031311
0.048924
0.052838
0.021526
0.011742
0.011742
0.013699
0.017613
0.021526
0.054795
0.021526
0.031311
0.033268
0.039139
0.019569
0.031311
0.039139
1
3,866
C
A
T
T
T
G
C
T
T
A
C
C
T
C
C
A
A
A
G
G
T
T
G
C
A
A
T
A
G
C
T
T
C
T
A
C
G
G
C
C
C
C
A
T
T
A
T
A
G
A
T
G
G
A
A
G
A
A
T
C
T
T
G
G
G
G
0.052838
0.029354
0.056751
0.035225
0.023483
0.029354
0.017613
0.029354
0.031311
0.046967
0.037182
0.017613
0.02544
0.033268
0.035225
0.029354
0.048924
0.052838
0.021526
0.011742
0.011742
0.013699
0.017613
0.021526
0.054795
0.021526
0.029354
0.033268
0.039139
0.019569
0.031311
0.041096
1
3,867
A
C
T
C
C
T
C
A
A
A
A
C
G
T
C
T
T
T
T
C
T
A
C
T
G
G
T
C
T
C
T
A
T
G
G
T
G
G
G
C
T
T
T
C
G
C
C
A
C
A
G
C
A
G
G
T
T
T
T
A
A
C
C
A
G
C
0.062622
0.035225
0.060665
0.033268
0.02544
0.031311
0.013699
0.031311
0.039139
0.046967
0.035225
0.019569
0.019569
0.029354
0.037182
0.031311
0.050881
0.046967
0.019569
0.005871
0.007828
0.011742
0.017613
0.023483
0.066536
0.015656
0.031311
0.023483
0.033268
0.019569
0.029354
0.04501
1
3,868
T
T
T
A
C
C
T
C
A
A
C
G
T
C
A
T
A
T
C
C
T
T
G
G
C
C
T
C
T
G
T
C
T
C
C
G
T
G
G
C
T
T
T
C
C
T
T
T
T
C
T
C
A
C
T
T
T
T
C
C
T
A
C
C
A
C
0.048924
0.029354
0.041096
0.013699
0.033268
0.035225
0.023483
0.031311
0.035225
0.050881
0.039139
0.021526
0.011742
0.031311
0.029354
0.043053
0.058708
0.046967
0.019569
0.015656
0.011742
0.019569
0.019569
0.037182
0.04501
0.021526
0.037182
0.043053
0.023483
0.029354
0.007828
0.04501
1
3,869
G
A
G
C
G
T
C
A
C
G
C
T
G
G
C
C
G
C
C
T
A
C
A
C
A
G
C
A
G
G
G
T
C
G
G
T
G
C
T
G
G
C
T
C
A
A
C
T
C
T
T
G
G
T
A
T
C
C
C
T
G
G
C
G
A
T
0.04501
0.02544
0.039139
0.013699
0.033268
0.037182
0.019569
0.031311
0.037182
0.04501
0.039139
0.023483
0.021526
0.039139
0.031311
0.039139
0.050881
0.043053
0.015656
0.019569
0.013699
0.021526
0.021526
0.039139
0.037182
0.023483
0.037182
0.041096
0.023483
0.035225
0.009785
0.046967
1
3,870
A
A
A
C
A
A
C
A
G
C
A
G
C
A
G
C
C
A
G
G
T
A
A
T
G
A
T
G
A
A
A
C
T
G
A
T
A
C
C
T
T
G
C
A
A
G
A
T
G
A
T
G
A
C
T
G
G
C
T
T
G
T
A
G
C
G
0.037182
0.029354
0.027397
0.031311
0.037182
0.04501
0.019569
0.029354
0.029354
0.037182
0.039139
0.023483
0.023483
0.037182
0.041096
0.029354
0.050881
0.041096
0.013699
0.02544
0.015656
0.021526
0.021526
0.035225
0.027397
0.021526
0.043053
0.035225
0.02544
0.048924
0.019569
0.037182
1
3,871
C
T
T
C
C
C
C
G
T
T
T
G
G
A
C
A
T
A
C
T
C
C
T
A
C
C
T
G
G
T
G
C
T
G
C
T
G
C
T
G
C
C
T
G
T
G
T
T
T
G
T
C
C
T
C
A
C
C
G
A
T
T
A
T
G
C
0.046967
0.027397
0.031311
0.035225
0.037182
0.043053
0.013699
0.029354
0.035225
0.031311
0.035225
0.02544
0.027397
0.037182
0.041096
0.031311
0.04501
0.041096
0.015656
0.027397
0.009785
0.019569
0.02544
0.031311
0.029354
0.019569
0.041096
0.033268
0.027397
0.046967
0.023483
0.035225
1
3,872
A
T
G
T
T
A
A
C
T
T
A
C
C
T
C
T
G
C
A
C
T
G
G
T
C
A
G
G
T
T
T
T
T
A
T
C
T
G
G
T
C
C
A
G
A
T
A
A
A
T
A
T
G
G
G
A
T
A
A
G
G
A
A
T
G
C
0.113503
0.043053
0.043053
0.043053
0.041096
0.021526
0
0.031311
0.037182
0.019569
0.029354
0.050881
0.041096
0.052838
0.035225
0.019569
0.039139
0.035225
0.017613
0
0.003914
0.003914
0.009785
0.027397
0.037182
0.015656
0.02544
0.009785
0.035225
0.015656
0.056751
0.04501
1
3,873
A
G
T
G
A
A
G
G
G
A
T
G
A
A
C
A
C
A
C
C
C
G
T
A
A
G
G
A
T
T
G
T
T
G
A
A
T
G
C
T
A
T
G
G
C
A
T
A
A
A
C
C
A
C
A
T
T
C
C
T
G
T
G
G
C
C
0.054795
0.037182
0.052838
0.041096
0.052838
0.019569
0.017613
0.019569
0.035225
0.04501
0.043053
0.048924
0.021526
0.029354
0.037182
0.041096
0.031311
0.029354
0.02544
0.005871
0.003914
0.011742
0.023483
0.033268
0.035225
0.017613
0.027397
0.017613
0.041096
0.013699
0.058708
0.027397
1
3,874
G
A
G
C
A
T
C
C
C
A
G
A
T
T
C
T
A
G
C
C
G
T
T
T
T
G
T
C
A
G
A
G
C
T
G
C
C
A
G
T
T
A
G
A
A
G
A
T
G
G
T
T
C
C
C
T
T
G
A
G
G
G
T
T
G
G
0.123288
0.031311
0.039139
0.041096
0.037182
0.017613
0.001957
0.031311
0.054795
0.027397
0.031311
0.02544
0.027397
0.050881
0.035225
0.019569
0.043053
0.037182
0.023483
0.001957
0
0
0.033268
0.027397
0.054795
0.019569
0.029354
0.021526
0.031311
0.017613
0.021526
0.043053
1
3,875
A
G
A
A
C
C
T
G
G
A
G
G
C
A
C
T
G
G
C
C
A
G
T
C
T
G
A
G
C
A
T
C
C
C
A
G
A
T
T
C
T
A
G
C
C
G
T
T
T
T
G
T
C
A
G
A
G
C
T
G
C
C
A
G
T
A
0.123288
0.029354
0.039139
0.046967
0.037182
0.017613
0.001957
0.031311
0.048924
0.027397
0.031311
0.031311
0.02544
0.052838
0.035225
0.019569
0.041096
0.033268
0.023483
0.001957
0
0
0.033268
0.02544
0.052838
0.019569
0.029354
0.021526
0.027397
0.017613
0.027397
0.046967
1
3,876
T
C
A
C
A
G
A
C
T
C
C
G
C
C
T
G
T
T
T
C
A
G
C
A
G
C
T
C
C
T
C
T
C
G
G
T
T
C
A
C
A
G
T
A
C
G
C
T
A
C
A
A
A
G
A
A
A
G
T
A
C
A
A
C
T
T
0.068493
0.043053
0.046967
0.054795
0.043053
0.02544
0.003914
0.039139
0.048924
0.033268
0.027397
0.029354
0.019569
0.037182
0.046967
0.021526
0.039139
0.027397
0.007828
0.007828
0.003914
0.003914
0.021526
0.041096
0.043053
0.013699
0.029354
0.017613
0.019569
0.033268
0.056751
0.04501
1
3,877
C
C
C
A
G
T
T
T
G
A
G
G
A
G
T
T
T
G
G
C
C
G
G
G
C
T
T
T
C
C
A
C
T
G
T
C
C
C
A
A
G
G
A
C
T
C
A
C
C
C
A
T
G
A
A
C
C
C
T
G
C
C
C
A
C
C
0.015656
0.013699
0.021526
0.005871
0.029354
0.04501
0.005871
0.031311
0.007828
0.037182
0.064579
0.003914
0.007828
0.019569
0.021526
0.064579
0.080235
0.066536
0.11546
0.027397
0.003914
0.013699
0.005871
0.033268
0.017613
0.02544
0.062622
0.07045
0.04501
0.007828
0.001957
0.027397
1
3,878
T
G
G
T
C
C
T
G
A
G
T
G
A
A
C
A
C
C
T
G
T
C
C
C
C
G
C
C
A
T
T
C
C
G
T
G
A
G
G
C
A
C
T
G
C
A
C
G
A
G
C
T
G
G
C
A
C
A
G
G
A
G
A
T
G
T
0.015656
0.011742
0.027397
0.007828
0.041096
0.050881
0.007828
0.013699
0.02544
0.046967
0.056751
0.005871
0.007828
0.037182
0.029354
0.058708
0.066536
0.088063
0.074364
0.013699
0.007828
0.021526
0.007828
0.041096
0.013699
0.033268
0.046967
0.064579
0.043053
0.009785
0.003914
0.019569
1
3,879
T
G
G
T
C
C
T
G
A
G
T
G
A
A
C
A
C
C
T
G
T
C
C
C
C
G
C
C
A
T
T
C
C
G
T
G
A
G
G
C
A
C
T
G
C
A
C
G
A
G
C
T
G
G
C
A
C
A
G
G
A
G
A
T
G
A
0.015656
0.011742
0.027397
0.007828
0.041096
0.050881
0.007828
0.013699
0.02544
0.046967
0.056751
0.005871
0.007828
0.037182
0.029354
0.058708
0.066536
0.088063
0.074364
0.013699
0.007828
0.021526
0.007828
0.041096
0.013699
0.033268
0.046967
0.064579
0.043053
0.009785
0.003914
0.019569
1
3,880
C
T
G
G
G
C
A
G
A
A
A
A
T
G
C
C
A
G
A
T
C
T
G
C
A
G
C
C
A
T
A
C
C
G
G
T
G
G
G
G
T
G
T
G
G
A
G
C
G
G
A
T
G
A
G
C
T
G
C
G
A
C
A
C
C
T
0.013699
0.009785
0.02544
0.003914
0.037182
0.054795
0.003914
0.015656
0.050881
0.039139
0.060665
0.003914
0.013699
0.033268
0.015656
0.046967
0.084149
0.074364
0.076321
0.015656
0.005871
0.013699
0.017613
0.041096
0.021526
0.046967
0.052838
0.04501
0.050881
0.007828
0.001957
0.015656
1
3,881
G
G
A
G
G
C
T
G
A
G
C
A
C
T
C
G
C
T
C
C
A
T
G
A
A
C
A
C
C
C
T
G
T
A
T
G
C
T
G
C
C
A
G
G
A
T
C
T
G
C
A
C
C
A
G
G
G
G
A
G
G
G
G
G
C
C
0.001957
0.011742
0.013699
0.005871
0.039139
0.033268
0.011742
0.009785
0.035225
0.048924
0.084149
0.001957
0.031311
0.031311
0.013699
0.039139
0.09589
0.060665
0.086106
0.001957
0.007828
0.009785
0.007828
0.062622
0.015656
0.031311
0.041096
0.056751
0.056751
0.011742
0.001957
0.039139
1
3,882
G
G
C
C
C
A
G
C
G
C
A
A
G
G
T
G
C
G
C
G
C
C
T
T
C
T
T
C
C
G
C
T
C
G
T
G
C
C
T
C
G
A
C
A
T
G
C
G
C
G
A
G
A
T
C
G
A
G
C
G
A
C
T
G
G
G
0.003914
0.011742
0.019569
0
0.013699
0.027397
0.027397
0.011742
0.011742
0.046967
0.050881
0.001957
0.017613
0.027397
0.015656
0.019569
0.04501
0.043053
0.050881
0.054795
0.052838
0.150685
0.011742
0.04501
0.015656
0.035225
0.035225
0.091977
0.031311
0.013699
0
0.015656
1
3,883
G
G
G
G
G
G
A
G
C
A
A
G
C
G
G
A
G
G
A
G
G
T
G
C
C
A
G
T
G
A
A
C
C
G
C
A
T
C
C
T
G
C
C
C
C
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C
C
C
C
A
A
G
G
T
G
A
G
A
A
G
G
C
A
G
G
0.003914
0.009785
0.019569
0.001957
0.013699
0.041096
0.017613
0.009785
0.013699
0.035225
0.064579
0
0.007828
0.009785
0.011742
0.043053
0.058708
0.041096
0.148728
0.07045
0.017613
0.062622
0
0.04501
0.019569
0.029354
0.050881
0.084149
0.050881
0
0
0.017613
1
3,884
A
C
G
G
G
C
C
T
C
T
C
T
C
A
C
T
G
C
T
T
C
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C
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C
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G
G
G
G
T
G
G
A
A
G
G
C
T
C
A
G
G
T
T
T
T
0.019569
0.013699
0.037182
0.005871
0.011742
0.037182
0.017613
0.017613
0.037182
0.035225
0.068493
0.003914
0.007828
0.013699
0.015656
0.033268
0.058708
0.041096
0.099804
0.043053
0.017613
0.035225
0.005871
0.056751
0.039139
0.021526
0.035225
0.082192
0.037182
0.015656
0.001957
0.033268
1
3,885
C
G
G
G
C
T
T
C
C
C
T
G
G
C
T
C
C
C
C
G
C
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G
A
A
C
A
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G
A
C
C
T
C
T
C
T
A
G
G
G
G
0.015656
0.013699
0.031311
0.007828
0.027397
0.023483
0.023483
0.019569
0.037182
0.039139
0.07045
0.001957
0.003914
0.017613
0.017613
0.037182
0.054795
0.043053
0.101761
0.039139
0.009785
0.021526
0.015656
0.062622
0.031311
0.037182
0.027397
0.072407
0.056751
0.005871
0.003914
0.029354
1
3,886
C
G
C
A
C
C
A
G
C
A
G
T
G
C
C
T
G
C
A
G
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A
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G
T
T
C
A
C
C
C
G
G
A
C
C
C
G
G
A
C
G
G
C
0.003914
0.007828
0.011742
0
0.015656
0.021526
0.009785
0.011742
0.02544
0.07045
0.060665
0.001957
0.001957
0.003914
0.001957
0.019569
0.093933
0.031311
0.105675
0.072407
0.011742
0.086106
0.005871
0.056751
0.017613
0.031311
0.058708
0.09002
0.054795
0
0
0.015656
1
3,887
T
C
C
T
G
T
C
C
G
G
T
C
C
G
C
A
G
A
G
C
T
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C
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T
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C
G
G
A
A
C
G
C
G
C
A
0.001957
0.007828
0.007828
0
0.013699
0.029354
0.009785
0.013699
0.023483
0.058708
0.058708
0.001957
0.005871
0.003914
0
0.02544
0.09002
0.039139
0.105675
0.078278
0.011742
0.09589
0.003914
0.050881
0.013699
0.02544
0.054795
0.099804
0.046967
0.007828
0.001957
0.011742
1
3,888
C
A
A
G
C
C
T
G
C
C
C
G
C
A
C
C
C
A
G
G
C
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G
G
A
G
C
C
C
A
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A
T
C
T
G
C
C
A
G
G
A
T
0.013699
0.013699
0.015656
0.001957
0.015656
0.04501
0.001957
0.027397
0.029354
0.031311
0.072407
0
0.013699
0.015656
0.009785
0.052838
0.074364
0.072407
0.127202
0.033268
0.003914
0.015656
0.009785
0.060665
0.021526
0.013699
0.033268
0.088063
0.046967
0.009785
0
0.029354
1
3,889
G
G
C
A
G
A
T
G
C
A
C
G
T
C
C
C
A
G
T
C
A
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G
C
T
G
A
C
A
C
T
G
G
G
G
C
T
G
C
T
G
G
C
0.003914
0.011742
0.015656
0.003914
0.029354
0.039139
0.009785
0.019569
0.023483
0.033268
0.066536
0
0.017613
0.029354
0.013699
0.048924
0.064579
0.07045
0.152642
0.029354
0.001957
0.013699
0.001957
0.060665
0.013699
0.029354
0.031311
0.058708
0.07045
0.005871
0.003914
0.02544
1
3,890
G
G
A
C
G
T
T
G
C
C
C
T
G
G
C
C
C
T
C
A
C
A
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C
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G
G
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G
A
G
A
G
G
C
C
C
T
C
C
G
G
T
G
C
T
G
G
C
0.007828
0.021526
0.023483
0.001957
0.031311
0.033268
0.011742
0.019569
0.02544
0.052838
0.076321
0.005871
0.013699
0.02544
0.021526
0.04501
0.072407
0.064579
0.086106
0.019569
0.003914
0.007828
0.011742
0.064579
0.02544
0.023483
0.037182
0.062622
0.066536
0.005871
0
0.031311
1
3,891
A
G
T
T
G
A
G
G
A
G
A
C
C
C
T
C
A
C
T
A
C
C
A
A
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G
T
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G
A
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A
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C
A
C
G
T
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A
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A
A
T
G
C
C
C
C
T
C
C
C
A
G
C
C
G
G
G
C
A
0.037182
0.011742
0.033268
0.027397
0.021526
0.037182
0.015656
0.02544
0.052838
0.043053
0.050881
0.009785
0.023483
0.021526
0.029354
0.048924
0.046967
0.048924
0.041096
0.019569
0.011742
0.011742
0.023483
0.068493
0.029354
0.015656
0.041096
0.041096
0.039139
0.023483
0.013699
0.035225
1
3,892
G
C
G
C
C
C
G
G
C
T
G
G
G
A
G
G
G
G
C
A
T
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C
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C
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G
G
T
A
G
T
G
A
G
G
G
T
C
T
C
C
T
C
A
A
T
0.037182
0.011742
0.033268
0.027397
0.021526
0.037182
0.015656
0.02544
0.054795
0.043053
0.050881
0.009785
0.023483
0.021526
0.029354
0.048924
0.04501
0.046967
0.041096
0.019569
0.011742
0.011742
0.023483
0.07045
0.029354
0.015656
0.041096
0.041096
0.039139
0.023483
0.013699
0.035225
1
3,893
C
A
G
A
C
A
A
C
C
G
G
C
T
G
A
A
G
T
G
G
A
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G
T
G
T
C
C
T
G
C
G
C
C
T
C
C
C
C
C
C
G
C
0.015656
0.019569
0.031311
0.017613
0.043053
0.021526
0.009785
0.033268
0.046967
0.04501
0.056751
0.005871
0.015656
0.027397
0.029354
0.041096
0.076321
0.048924
0.054795
0.013699
0.001957
0.005871
0.013699
0.060665
0.031311
0.035225
0.046967
0.035225
0.060665
0.011742
0.007828
0.035225
1
3,894
C
C
C
T
C
T
T
C
T
A
C
A
T
C
A
T
C
A
A
C
A
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C
C
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G
G
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C
C
C
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C
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C
A
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C
C
T
T
C
A
T
G
G
T
C
A
A
C
C
T
G
G
T
C
C
0.001957
0.009785
0.019569
0.007828
0.02544
0.035225
0.011742
0.009785
0.035225
0.039139
0.078278
0.003914
0.02544
0.033268
0.017613
0.031311
0.076321
0.072407
0.103718
0.023483
0
0.011742
0.015656
0.050881
0.017613
0.031311
0.027397
0.082192
0.054795
0.009785
0.001957
0.035225
1
3,895
C
T
C
C
T
T
C
A
T
G
G
T
C
A
A
C
C
T
G
G
T
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G
C
C
T
C
C
A
G
G
C
C
C
C
G
T
C
C
C
C
T
A
0.001957
0.009785
0.023483
0.005871
0.023483
0.035225
0.011742
0.011742
0.039139
0.037182
0.076321
0.003914
0.029354
0.035225
0.017613
0.033268
0.07045
0.07045
0.099804
0.02544
0
0.009785
0.017613
0.052838
0.019569
0.027397
0.027397
0.078278
0.056751
0.011742
0.001957
0.035225
1
3,896
C
C
T
G
T
G
G
G
T
G
C
T
G
A
G
G
G
T
G
C
C
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T
A
T
C
G
T
G
C
T
G
G
A
G
A
A
C
A
A
G
T
G
0.009785
0.011742
0.023483
0.001957
0.021526
0.043053
0.009785
0.017613
0.043053
0.029354
0.082192
0.007828
0.021526
0.015656
0.015656
0.052838
0.076321
0.060665
0.09589
0.015656
0.013699
0.015656
0.017613
0.052838
0.019569
0.019569
0.066536
0.072407
0.04501
0.007828
0.001957
0.011742
1
3,897
G
T
C
C
C
C
T
G
A
C
G
G
C
T
G
T
A
T
C
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G
T
T
C
C
G
C
C
T
G
C
T
C
T
A
T
C
T
C
A
G
G
0.001957
0.007828
0.027397
0.009785
0.029354
0.033268
0.011742
0.021526
0.041096
0.04501
0.07045
0.011742
0.017613
0.015656
0.011742
0.04501
0.084149
0.068493
0.088063
0.015656
0.013699
0.005871
0.021526
0.043053
0.021526
0.029354
0.039139
0.086106
0.037182
0.013699
0.011742
0.019569
1
3,898
A
C
C
A
G
A
A
G
G
T
G
G
T
G
T
T
C
T
A
C
C
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C
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C
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T
C
T
A
C
G
T
C
A
T
C
A
A
C
A
T
C
A
T
C
T
0
0.009785
0.033268
0.003914
0.02544
0.041096
0.007828
0.015656
0.031311
0.046967
0.078278
0.001957
0.023483
0.029354
0.013699
0.04501
0.078278
0.066536
0.086106
0.013699
0.009785
0.019569
0.017613
0.043053
0.027397
0.017613
0.056751
0.062622
0.052838
0.017613
0.005871
0.017613
1
3,899
T
T
C
T
G
A
C
G
A
A
T
G
T
C
C
A
T
T
C
T
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T
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C
C
A
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A
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C
A
T
C
A
A
G
T
C
C
0.058708
0.021526
0.035225
0.04501
0.035225
0.027397
0.007828
0.037182
0.04501
0.02544
0.033268
0.015656
0.039139
0.041096
0.041096
0.031311
0.043053
0.048924
0.013699
0.013699
0.013699
0.003914
0.027397
0.035225
0.046967
0.027397
0.027397
0.02544
0.043053
0.027397
0.015656
0.046967
1
3,900
C
T
T
T
T
G
T
G
G
C
G
A
A
G
A
T
T
G
C
C
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T
T
C
G
C
T
T
T
A
C
T
G
A
C
A
C
A
G
C
A
T
0.091977
0.019569
0.04501
0.062622
0.033268
0.02544
0.005871
0.039139
0.043053
0.023483
0.017613
0.031311
0.033268
0.041096
0.039139
0.033268
0.035225
0.043053
0.007828
0.009785
0.011742
0.003914
0.02544
0.019569
0.050881
0.023483
0.021526
0.02544
0.019569
0.027397
0.037182
0.052838
1
3,901
T
G
G
C
G
A
A
T
G
C
T
T
T
G
A
C
C
T
C
A
A
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C
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G
T
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G
A
G
A
G
A
G
A
G
C
A
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A
C
A
G
G
C
A
G
A
0.048924
0.013699
0.033268
0.017613
0.043053
0.039139
0.003914
0.019569
0.048924
0.021526
0.046967
0.011742
0.02544
0.039139
0.037182
0.04501
0.043053
0.058708
0.076321
0.015656
0.013699
0.013699
0.011742
0.048924
0.023483
0.033268
0.037182
0.041096
0.043053
0.013699
0.005871
0.02544
1
3,902
T
G
G
G
G
C
A
C
T
G
G
G
T
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G
C
C
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C
A
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C
A
A
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A
A
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A
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C
A
G
T
G
G
G
C
T
0.048924
0.021526
0.043053
0.027397
0.039139
0.019569
0.015656
0.023483
0.052838
0.035225
0.046967
0.015656
0.015656
0.046967
0.033268
0.033268
0.064579
0.033268
0.033268
0.007828
0.005871
0.005871
0.011742
0.041096
0.048924
0.027397
0.062622
0.037182
0.031311
0.015656
0.011742
0.043053
1
3,903
T
A
G
T
G
G
A
T
T
T
T
G
G
T
G
A
A
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C
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A
A
C
C
A
T
A
T
T
G
G
G
C
A
T
G
A
T
G
G
G
C
C
T
A
G
G
0.054795
0.021526
0.039139
0.04501
0.031311
0.02544
0.011742
0.023483
0.054795
0.019569
0.043053
0.033268
0.039139
0.043053
0.037182
0.029354
0.04501
0.039139
0.027397
0.005871
0.007828
0.005871
0.019569
0.039139
0.04501
0.023483
0.039139
0.02544
0.037182
0.017613
0.023483
0.046967
1
3,904
T
C
T
G
C
T
C
T
T
T
T
T
G
C
C
C
C
T
C
C
C
A
G
G
T
C
C
T
G
T
G
G
C
G
G
T
A
C
A
C
T
G
G
A
A
C
C
C
G
A
C
C
A
T
C
G
A
A
T
C
T
T
G
C
G
T
0.068493
0.043053
0.046967
0.041096
0.04501
0.027397
0.011742
0.029354
0.041096
0.027397
0.033268
0.039139
0.037182
0.023483
0.048924
0.029354
0.037182
0.035225
0.031311
0.009785
0.011742
0.005871
0.029354
0.017613
0.039139
0.013699
0.033268
0.019569
0.029354
0.027397
0.041096
0.02544
1
3,905
C
C
A
A
T
C
C
G
C
C
C
A
A
C
A
T
A
C
C
A
A
G
C
A
G
A
T
C
G
T
T
T
T
G
G
G
G
T
A
G
C
C
A
C
T
T
A
A
C
A
A
G
T
A
T
C
G
T
G
T
T
G
T
T
C
C
0.066536
0.048924
0.043053
0.031311
0.048924
0.027397
0.007828
0.033268
0.046967
0.027397
0.031311
0.033268
0.033268
0.027397
0.04501
0.027397
0.043053
0.039139
0.029354
0.009785
0.011742
0.005871
0.029354
0.02544
0.043053
0.017613
0.027397
0.021526
0.031311
0.023483
0.035225
0.027397
1
3,906
G
A
T
G
A
C
C
C
G
T
G
C
C
T
T
T
A
T
C
A
C
C
C
A
T
G
C
T
G
G
T
T
C
C
C
A
T
G
G
T
G
T
T
T
A
T
G
A
A
A
G
C
A
T
A
T
G
C
A
A
T
G
G
C
G
T
0.074364
0.029354
0.039139
0.043053
0.039139
0.027397
0.003914
0.023483
0.046967
0.02544
0.023483
0.035225
0.037182
0.076321
0.039139
0.027397
0.035225
0.039139
0.02544
0.003914
0.001957
0.005871
0.021526
0.02544
0.046967
0.023483
0.041096
0.013699
0.02544
0.015656
0.02544
0.058708
1
3,907
A
T
C
A
C
C
A
A
A
C
A
A
G
G
G
C
A
T
C
A
T
C
A
C
C
A
T
G
G
G
A
A
C
G
C
C
A
T
T
G
C
A
T
A
T
G
C
T
T
T
C
A
T
A
A
A
C
A
C
C
A
T
G
G
G
A
0.076321
0.031311
0.035225
0.041096
0.039139
0.027397
0.009785
0.023483
0.04501
0.02544
0.021526
0.037182
0.035225
0.078278
0.037182
0.027397
0.035225
0.039139
0.02544
0.003914
0.001957
0.007828
0.021526
0.023483
0.04501
0.023483
0.043053
0.013699
0.023483
0.017613
0.027397
0.056751
1
3,908
T
C
T
C
C
A
T
G
C
G
C
T
T
T
G
C
A
T
T
G
T
C
C
A
T
C
T
G
A
T
C
A
C
C
A
A
A
C
A
A
G
G
G
C
A
T
C
A
T
C
A
C
C
A
T
G
G
G
A
A
C
G
C
C
A
A
0.088063
0.031311
0.033268
0.04501
0.039139
0.027397
0.009785
0.023483
0.046967
0.023483
0.019569
0.035225
0.037182
0.074364
0.035225
0.027397
0.037182
0.037182
0.02544
0.003914
0.001957
0.007828
0.019569
0.023483
0.04501
0.023483
0.041096
0.009785
0.023483
0.017613
0.029354
0.056751
1
3,909
G
C
C
C
G
G
T
G
G
A
G
C
C
G
C
T
G
G
A
C
C
T
G
G
C
C
G
T
G
T
T
C
T
G
G
G
T
G
G
A
G
T
T
T
G
T
G
A
T
G
A
G
G
C
A
C
A
A
G
G
G
C
G
C
G
C
0.056751
0.043053
0.046967
0.02544
0.048924
0.041096
0.013699
0.019569
0.033268
0.02544
0.043053
0.015656
0.015656
0.029354
0.046967
0.041096
0.037182
0.056751
0.033268
0.021526
0.007828
0.023483
0.009785
0.027397
0.039139
0.019569
0.023483
0.04501
0.035225
0.019569
0.029354
0.02544
1
3,910
G
T
A
G
G
G
C
A
G
C
C
A
G
C
A
G
A
C
A
A
G
G
A
A
G
A
C
C
A
C
C
A
C
G
T
A
G
G
A
G
A
A
G
A
T
G
A
T
C
T
T
C
C
G
G
C
T
G
C
T
G
T
G
C
T
T
0.007828
0.011742
0.04501
0.005871
0.035225
0.033268
0.031311
0.021526
0.048924
0.052838
0.046967
0.001957
0.029354
0.029354
0.02544
0.043053
0.07045
0.043053
0.019569
0.029354
0.015656
0.017613
0.019569
0.035225
0.035225
0.039139
0.052838
0.048924
0.037182
0.027397
0.001957
0.037182
1
3,911
C
C
A
T
T
T
G
T
A
A
A
A
C
A
A
A
A
C
C
A
A
G
C
T
T
G
C
A
T
A
C
C
T
T
C
T
C
T
C
C
T
G
G
G
A
A
T
C
C
C
C
G
A
G
A
G
C
C
C
T
A
G
A
A
G
C
0.062622
0.027397
0.048924
0.039139
0.023483
0.029354
0.003914
0.035225
0.052838
0.027397
0.04501
0.019569
0.019569
0.023483
0.033268
0.02544
0.043053
0.048924
0.04501
0.011742
0.009785
0.009785
0.031311
0.037182
0.052838
0.019569
0.031311
0.029354
0.04501
0.019569
0.027397
0.021526
1
3,912
T
C
T
G
G
C
C
C
G
G
G
C
A
G
C
C
C
T
G
G
A
A
A
C
C
T
T
G
A
G
T
G
C
C
G
T
T
C
A
C
A
C
C
A
G
G
C
G
G
A
C
C
A
C
G
C
T
C
A
C
C
C
T
G
T
T
0.02544
0.023483
0.027397
0.013699
0.011742
0.039139
0.017613
0.015656
0.035225
0.054795
0.068493
0.001957
0.015656
0.027397
0.019569
0.035225
0.080235
0.046967
0.066536
0.015656
0.007828
0.017613
0.007828
0.058708
0.041096
0.013699
0.056751
0.054795
0.037182
0.011742
0.003914
0.046967
1
3,913
G
G
C
A
G
C
C
C
T
G
G
A
A
A
C
C
T
T
G
A
G
T
G
C
C
G
T
T
C
A
C
A
C
C
A
G
G
C
G
G
A
C
C
A
C
G
C
T
C
A
C
C
C
T
G
T
T
G
T
G
A
G
A
G
A
A
0.021526
0.021526
0.027397
0.011742
0.011742
0.039139
0.017613
0.013699
0.035225
0.058708
0.068493
0
0.015656
0.027397
0.019569
0.035225
0.084149
0.046967
0.066536
0.015656
0.007828
0.021526
0.007828
0.058708
0.037182
0.013699
0.060665
0.054795
0.037182
0.011742
0.003914
0.046967
1
3,914
G
A
A
A
C
C
T
T
G
A
G
T
G
C
C
G
T
T
C
A
C
A
C
C
A
G
G
C
G
G
A
C
C
A
C
G
C
T
C
A
C
C
C
T
G
T
T
G
T
G
A
G
A
G
A
C
A
A
A
G
G
C
A
T
T
T
0.021526
0.021526
0.027397
0.009785
0.013699
0.039139
0.017613
0.015656
0.033268
0.060665
0.068493
0
0.015656
0.02544
0.019569
0.037182
0.088063
0.04501
0.066536
0.015656
0.007828
0.021526
0.007828
0.054795
0.035225
0.015656
0.064579
0.054795
0.035225
0.011742
0.003914
0.04501
1
3,915
T
C
C
A
C
C
C
T
C
A
T
C
A
C
C
A
G
G
A
T
A
G
C
C
T
C
G
G
T
A
G
C
C
G
T
C
T
T
C
T
C
C
A
G
G
A
A
T
A
C
C
C
T
G
A
A
A
C
A
A
A
G
T
A
A
A
0.064579
0.023483
0.04501
0.046967
0.031311
0.023483
0.009785
0.035225
0.041096
0.029354
0.043053
0.015656
0.035225
0.035225
0.035225
0.021526
0.043053
0.033268
0.04501
0.009785
0.007828
0
0.023483
0.037182
0.039139
0.019569
0.029354
0.019569
0.043053
0.033268
0.041096
0.039139
1
3,916
A
T
A
G
C
C
T
C
G
G
T
A
G
C
C
G
T
C
T
T
C
T
C
C
A
G
G
A
A
T
A
C
C
C
T
G
A
A
A
C
A
A
A
G
T
A
A
T
C
G
G
G
T
C
C
T
C
T
G
T
T
T
A
A
T
A
0.062622
0.023483
0.043053
0.046967
0.029354
0.023483
0.009785
0.033268
0.037182
0.033268
0.043053
0.015656
0.033268
0.037182
0.033268
0.021526
0.046967
0.035225
0.043053
0.009785
0.009785
0.001957
0.023483
0.035225
0.041096
0.019569
0.033268
0.021526
0.043053
0.031311
0.039139
0.039139
1
3,917
C
T
C
A
G
G
C
G
T
G
G
G
C
A
A
G
G
G
T
A
A
A
G
C
C
A
C
C
G
T
A
C
C
T
T
T
G
G
C
C
C
G
A
T
G
C
T
G
C
C
G
A
T
G
G
G
C
C
C
G
C
G
G
T
C
A
0.043053
0.021526
0.04501
0.02544
0.035225
0.037182
0.013699
0.011742
0.056751
0.033268
0.046967
0.011742
0.031311
0.033268
0.02544
0.035225
0.050881
0.037182
0.054795
0.021526
0.017613
0.013699
0.007828
0.043053
0.041096
0.029354
0.039139
0.031311
0.037182
0.011742
0.023483
0.033268
1
3,918
A
C
A
C
G
C
C
A
A
C
A
C
T
A
A
G
G
T
G
G
G
C
C
T
T
G
A
G
C
A
C
C
T
G
C
G
G
G
T
A
A
A
C
C
A
C
T
T
T
G
T
G
C
C
T
G
A
G
G
C
A
G
G
C
A
G
0.027397
0.035225
0.041096
0.013699
0.043053
0.027397
0.019569
0.037182
0.027397
0.027397
0.050881
0.011742
0.02544
0.015656
0.04501
0.046967
0.052838
0.054795
0.039139
0.015656
0.017613
0.02544
0.009785
0.039139
0.039139
0.037182
0.02544
0.035225
0.058708
0.009785
0.007828
0.037182
1
3,919
C
T
G
C
C
T
C
A
G
G
C
A
C
A
A
A
G
T
G
G
T
T
T
A
C
C
C
G
C
A
G
G
T
G
C
T
C
A
A
G
G
C
C
C
A
C
C
T
T
A
G
T
G
T
T
G
G
C
G
T
G
T
C
T
T
G
0.027397
0.035225
0.041096
0.015656
0.04501
0.027397
0.019569
0.037182
0.027397
0.02544
0.050881
0.011742
0.02544
0.015656
0.04501
0.046967
0.052838
0.054795
0.039139
0.015656
0.017613
0.02544
0.009785
0.039139
0.039139
0.037182
0.023483
0.035225
0.058708
0.009785
0.007828
0.037182
1
3,920
G
A
G
A
T
T
T
T
G
A
C
C
T
C
C
G
A
A
G
G
A
A
A
G
A
A
G
A
G
G
A
A
C
G
G
C
T
A
G
A
G
T
G
A
G
T
G
T
G
C
C
G
T
G
C
T
G
A
G
C
C
C
A
C
G
T
0.027397
0.029354
0.052838
0.019569
0.043053
0.031311
0.013699
0.033268
0.058708
0.035225
0.031311
0.009785
0.031311
0.027397
0.039139
0.041096
0.062622
0.050881
0.04501
0.013699
0.005871
0.001957
0.007828
0.035225
0.052838
0.041096
0.017613
0.027397
0.037182
0.009785
0.007828
0.058708
1
3,921
G
T
A
G
C
T
G
C
A
C
T
G
G
C
T
G
G
T
G
A
G
C
G
A
C
G
C
C
A
C
A
C
T
C
T
C
T
G
C
C
T
T
G
C
C
C
G
G
C
A
G
T
G
C
C
A
G
C
G
A
G
G
T
C
A
C
0.037182
0.027397
0.02544
0.019569
0.039139
0.031311
0.013699
0.029354
0.037182
0.035225
0.031311
0.009785
0.02544
0.046967
0.023483
0.052838
0.054795
0.060665
0.054795
0.021526
0.009785
0.017613
0.015656
0.037182
0.027397
0.015656
0.054795
0.048924
0.033268
0.017613
0.019569
0.02544
1
3,922
A
G
G
C
G
G
A
C
G
C
A
G
G
A
G
G
C
G
C
T
G
G
G
G
A
A
A
G
T
G
A
T
T
C
G
G
A
G
G
C
C
G
C
C
G
C
T
G
A
C
C
G
A
G
A
A
G
C
T
G
C
T
G
A
G
G
0.003914
0.009785
0.007828
0.003914
0.009785
0.04501
0.017613
0.007828
0.001957
0.041096
0.037182
0
0.009785
0.009785
0.001957
0.041096
0.041096
0.031311
0.097847
0.150685
0.023483
0.093933
0.007828
0.031311
0.017613
0.027397
0.027397
0.136986
0.035225
0.001957
0.001957
0.02544
1
3,923
T
T
C
T
C
C
C
T
T
C
T
C
T
C
C
A
G
C
T
A
A
A
A
C
C
C
T
C
C
G
C
A
C
C
G
C
A
T
C
G
T
C
A
C
T
A
G
A
G
A
G
C
T
T
G
T
C
G
T
C
C
A
A
A
T
T
0.086106
0.019569
0.041096
0.058708
0.037182
0.017613
0.013699
0.029354
0.056751
0.02544
0.027397
0.04501
0.031311
0.037182
0.033268
0.035225
0.021526
0.019569
0.007828
0.009785
0.011742
0.015656
0.031311
0.04501
0.052838
0.023483
0.015656
0.009785
0.029354
0.021526
0.035225
0.054795
1
3,924
T
T
T
G
G
A
C
G
A
C
A
A
G
C
T
C
T
C
T
A
G
T
G
A
C
G
A
T
G
C
G
G
T
G
C
G
G
A
G
G
G
T
T
T
T
A
G
C
T
G
G
A
G
A
G
A
A
G
G
G
A
G
A
A
G
C
0.086106
0.019569
0.041096
0.058708
0.039139
0.017613
0.013699
0.029354
0.056751
0.02544
0.027397
0.04501
0.031311
0.037182
0.033268
0.035225
0.021526
0.019569
0.007828
0.009785
0.011742
0.015656
0.031311
0.04501
0.050881
0.023483
0.015656
0.009785
0.029354
0.021526
0.035225
0.054795
1
3,925
G
G
C
C
T
C
G
T
T
G
A
G
C
G
A
C
T
G
G
G
T
G
C
G
C
T
G
G
C
G
C
T
C
G
C
G
C
A
C
G
T
T
G
G
C
C
A
G
G
A
T
G
C
G
C
T
G
G
C
T
C
T
G
C
A
T
0
0.003914
0.035225
0.001957
0.015656
0.015656
0.029354
0.007828
0.029354
0.082192
0.041096
0.003914
0.017613
0.023483
0.021526
0.023483
0.060665
0.058708
0.054795
0.033268
0.035225
0.105675
0.009785
0.054795
0.017613
0.029354
0.043053
0.076321
0.041096
0.011742
0.001957
0.013699
1
3,926
G
G
C
C
T
C
G
T
T
G
A
G
C
G
A
C
T
G
G
G
T
G
C
G
C
T
G
G
C
G
C
T
C
G
C
G
C
A
C
G
T
T
G
G
C
C
A
G
G
A
T
G
C
G
C
T
G
G
C
T
C
T
G
C
A
G
0
0.003914
0.035225
0.001957
0.015656
0.015656
0.029354
0.007828
0.029354
0.082192
0.041096
0.003914
0.017613
0.023483
0.021526
0.023483
0.060665
0.058708
0.054795
0.033268
0.035225
0.105675
0.009785
0.054795
0.017613
0.029354
0.043053
0.076321
0.041096
0.011742
0.001957
0.013699
1
3,927
A
G
G
C
C
T
C
G
T
T
G
A
G
C
G
A
C
T
G
G
G
T
G
C
G
C
T
G
G
C
G
C
T
C
G
C
G
C
A
C
G
T
T
G
G
C
C
A
G
G
A
T
G
C
G
C
T
G
G
C
T
C
T
G
C
G
0
0.003914
0.035225
0.001957
0.015656
0.015656
0.029354
0.007828
0.029354
0.082192
0.041096
0.003914
0.017613
0.023483
0.021526
0.02544
0.060665
0.058708
0.054795
0.033268
0.035225
0.103718
0.009785
0.054795
0.017613
0.029354
0.043053
0.076321
0.041096
0.011742
0.001957
0.013699
1
3,928
T
A
A
T
G
A
C
A
T
C
T
C
C
T
T
T
T
T
G
T
G
C
A
G
C
T
T
C
T
G
A
A
C
C
G
A
A
T
C
T
G
A
A
A
T
T
A
C
G
G
T
C
C
A
G
G
C
T
A
A
A
G
C
A
G
G
0.060665
0.021526
0.02544
0.035225
0.037182
0.029354
0.023483
0.017613
0.037182
0.050881
0.039139
0.019569
0.019569
0.019569
0.021526
0.043053
0.076321
0.043053
0.037182
0.017613
0.011742
0.017613
0.007828
0.035225
0.033268
0.02544
0.046967
0.039139
0.031311
0.015656
0.027397
0.033268
1
3,929
G
C
T
T
T
A
G
C
C
T
G
G
A
C
C
G
T
A
A
T
T
T
C
A
G
A
T
T
C
G
G
T
T
C
A
G
A
A
G
C
T
G
C
A
C
A
A
A
A
A
G
G
A
G
A
T
G
T
C
A
T
T
A
C
A
C
0.060665
0.021526
0.02544
0.035225
0.035225
0.029354
0.023483
0.017613
0.037182
0.050881
0.039139
0.019569
0.019569
0.019569
0.021526
0.043053
0.074364
0.043053
0.037182
0.017613
0.011742
0.021526
0.007828
0.035225
0.033268
0.02544
0.046967
0.039139
0.031311
0.015656
0.027397
0.033268
1
3,930
C
G
A
C
G
C
C
A
A
A
G
A
T
G
A
C
T
T
C
C
C
T
C
T
T
A
G
G
A
A
A
A
C
A
G
G
T
C
A
G
T
G
C
C
C
A
G
G
C
A
T
G
C
T
G
T
G
G
G
C
C
G
G
G
A
A
0.066536
0.029354
0.041096
0.019569
0.035225
0.035225
0.017613
0.02544
0.041096
0.02544
0.052838
0.019569
0.019569
0.027397
0.017613
0.052838
0.048924
0.039139
0.041096
0.015656
0.011742
0.017613
0.017613
0.035225
0.04501
0.021526
0.043053
0.031311
0.039139
0.009785
0.027397
0.029354
1
3,931
G
C
T
C
A
A
G
C
A
G
G
A
C
A
A
T
C
G
C
A
C
T
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T
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T
A
C
C
A
C
C
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C
G
A
T
T
A
C
T
G
T
A
A
G
T
G
C
A
T
C
T
G
T
G
T
G
G
G
G
G
C
T
C
0.066536
0.027397
0.037182
0.058708
0.035225
0.031311
0.003914
0.031311
0.031311
0.033268
0.039139
0.027397
0.023483
0.027397
0.035225
0.039139
0.052838
0.041096
0.033268
0.007828
0.007828
0.003914
0.021526
0.02544
0.035225
0.015656
0.046967
0.02544
0.031311
0.019569
0.052838
0.031311
1
3,932
T
G
G
T
C
A
G
C
A
A
G
T
G
C
T
C
C
A
A
G
G
C
A
T
C
T
G
A
G
T
A
C
T
G
C
A
G
C
A
G
G
C
G
A
C
T
G
C
T
G
T
A
C
A
A
C
C
A
G
G
A
C
T
G
C
C
0.043053
0.031311
0.033268
0.043053
0.035225
0.017613
0.005871
0.052838
0.041096
0.029354
0.02544
0.017613
0.039139
0.031311
0.035225
0.035225
0.064579
0.037182
0.023483
0.011742
0.015656
0.009785
0.017613
0.033268
0.04501
0.019569
0.048924
0.021526
0.035225
0.02544
0.029354
0.04501
1
3,933
C
A
T
T
G
C
A
G
C
G
G
A
T
C
T
G
C
T
T
G
G
C
C
C
G
G
T
C
A
G
C
A
T
A
C
C
T
G
G
G
T
G
G
C
A
G
A
G
G
G
G
G
C
T
G
T
G
G
G
C
T
G
T
G
C
C
0.011742
0.007828
0.029354
0.007828
0.035225
0.039139
0.001957
0.017613
0.027397
0.052838
0.064579
0.001957
0.021526
0.023483
0.033268
0.041096
0.086106
0.068493
0.082192
0.017613
0.013699
0.021526
0.003914
0.043053
0.009785
0.037182
0.043053
0.076321
0.033268
0.007828
0.001957
0.037182
1
3,934
T
G
C
A
G
A
C
A
T
C
A
A
C
T
A
C
G
A
T
G
A
G
A
C
C
C
T
T
A
G
C
A
C
G
C
T
G
A
G
G
T
G
A
G
T
T
C
T
C
C
A
G
G
G
A
G
A
C
A
A
G
C
T
C
T
T
0.009785
0.017613
0.035225
0.007828
0.035225
0.035225
0.007828
0.019569
0.043053
0.043053
0.068493
0.011742
0.015656
0.023483
0.023483
0.037182
0.07045
0.056751
0.111546
0.005871
0.005871
0.007828
0.017613
0.052838
0.023483
0.029354
0.033268
0.052838
0.043053
0.013699
0.011742
0.029354
1
3,935
G
A
A
C
T
C
A
C
C
T
C
A
G
C
G
T
G
C
T
A
A
G
G
G
T
C
T
C
A
T
C
G
T
A
G
T
T
G
A
T
G
T
C
T
G
C
A
G
G
A
C
T
C
A
A
G
G
C
T
G
C
C
A
C
C
C
0.009785
0.017613
0.039139
0.007828
0.035225
0.033268
0.005871
0.019569
0.043053
0.046967
0.07045
0.011742
0.015656
0.02544
0.02544
0.033268
0.068493
0.052838
0.105675
0.003914
0.005871
0.007828
0.017613
0.054795
0.027397
0.029354
0.033268
0.048924
0.046967
0.013699
0.011742
0.031311
1
3,936
A
A
G
G
A
C
A
G
C
T
A
T
G
G
T
G
G
C
A
G
C
C
T
T
G
A
G
T
C
C
T
G
C
A
G
A
C
A
T
C
A
A
C
T
A
C
G
A
T
G
A
G
A
C
C
C
T
T
A
G
C
A
C
G
C
T
0.009785
0.019569
0.039139
0.007828
0.035225
0.035225
0.005871
0.019569
0.046967
0.043053
0.07045
0.011742
0.017613
0.02544
0.02544
0.033268
0.066536
0.054795
0.103718
0.003914
0.005871
0.007828
0.017613
0.056751
0.029354
0.029354
0.027397
0.04501
0.046967
0.013699
0.011742
0.033268
1
3,937
G
T
T
C
T
C
A
C
C
C
A
G
G
T
T
T
T
C
C
C
G
G
A
G
G
A
G
C
C
A
G
G
T
C
A
A
C
A
C
G
G
A
A
T
C
T
C
G
G
T
A
C
G
G
A
A
T
G
A
A
A
T
C
T
G
G
0.019569
0.023483
0.033268
0.009785
0.023483
0.035225
0.009785
0.017613
0.039139
0.037182
0.076321
0
0.007828
0.005871
0.019569
0.035225
0.082192
0.066536
0.101761
0.019569
0.013699
0.015656
0.003914
0.050881
0.043053
0.023483
0.027397
0.078278
0.046967
0.003914
0.003914
0.02544
1
3,938
G
C
C
A
C
T
C
A
C
C
A
T
T
T
C
A
G
C
C
A
G
G
G
C
G
G
A
G
A
T
G
A
C
C
T
T
G
C
C
C
A
G
G
G
T
G
G
T
C
A
G
C
G
A
C
T
T
G
T
T
G
A
T
G
T
G
0.017613
0.019569
0.019569
0.001957
0.027397
0.035225
0.005871
0.023483
0.033268
0.035225
0.054795
0.003914
0.015656
0.027397
0.019569
0.04501
0.076321
0.086106
0.11546
0.029354
0.003914
0.013699
0.005871
0.04501
0.019569
0.023483
0.033268
0.09002
0.04501
0.003914
0.001957
0.021526
1
3,939
C
A
C
C
A
T
T
T
C
A
G
C
C
A
G
G
G
C
G
G
A
G
A
T
G
A
C
C
T
T
G
C
C
C
A
G
G
G
T
G
G
T
C
A
G
C
G
A
C
T
T
G
T
T
G
A
T
G
T
T
G
G
C
C
C
G
0.019569
0.021526
0.019569
0.001957
0.027397
0.035225
0.005871
0.023483
0.033268
0.035225
0.054795
0.003914
0.015656
0.029354
0.021526
0.04501
0.076321
0.084149
0.111546
0.027397
0.003914
0.013699
0.005871
0.04501
0.019569
0.023483
0.037182
0.086106
0.04501
0.003914
0.001957
0.021526
1
3,940
G
G
T
G
G
T
C
A
G
C
G
A
C
T
T
G
T
T
G
A
T
G
T
T
G
G
C
C
C
C
C
T
C
C
T
G
C
G
G
G
C
A
G
A
A
A
A
G
A
C
A
G
T
G
G
G
G
T
T
G
G
G
A
T
G
G
0.017613
0.017613
0.019569
0.003914
0.02544
0.037182
0.005871
0.019569
0.033268
0.035225
0.056751
0.005871
0.021526
0.035225
0.019569
0.041096
0.076321
0.080235
0.113503
0.027397
0.003914
0.011742
0.003914
0.04501
0.021526
0.02544
0.039139
0.078278
0.048924
0.001957
0
0.027397
1
3,941
C
A
G
C
C
T
G
G
T
G
G
A
C
C
T
G
G
C
T
G
G
G
A
G
C
G
A
G
C
G
G
G
C
T
G
A
C
T
C
C
A
C
G
G
G
A
G
C
C
A
A
G
G
G
C
A
C
G
C
G
C
C
T
C
A
T
0.013699
0.011742
0.019569
0.003914
0.021526
0.039139
0.011742
0.013699
0.015656
0.04501
0.07045
0.005871
0.009785
0.023483
0.027397
0.039139
0.072407
0.068493
0.109589
0.035225
0.005871
0.037182
0.007828
0.04501
0.007828
0.027397
0.046967
0.09002
0.04501
0.005871
0
0.023483
1
3,942
G
G
C
G
C
G
T
G
C
C
C
T
T
G
G
C
T
C
C
C
G
T
G
G
A
G
T
C
A
G
C
C
C
G
C
T
C
G
C
T
C
C
C
A
G
C
C
A
G
G
T
C
C
A
C
C
A
G
G
C
T
G
A
T
T
G
0.013699
0.011742
0.019569
0.003914
0.021526
0.037182
0.011742
0.013699
0.015656
0.04501
0.07045
0.005871
0.009785
0.023483
0.027397
0.039139
0.072407
0.068493
0.109589
0.033268
0.005871
0.037182
0.007828
0.04501
0.007828
0.027397
0.048924
0.091977
0.04501
0.005871
0
0.023483
1
3,943
C
G
T
G
C
C
C
T
T
G
G
C
T
C
C
C
G
T
G
G
A
G
T
C
A
G
C
C
C
G
C
T
C
G
C
T
C
C
C
A
G
C
C
A
G
G
T
C
C
A
C
C
A
G
G
C
T
G
A
T
T
T
T
G
C
T
0.013699
0.011742
0.019569
0.003914
0.021526
0.037182
0.009785
0.013699
0.015656
0.046967
0.07045
0.005871
0.009785
0.023483
0.027397
0.039139
0.074364
0.07045
0.109589
0.033268
0.005871
0.037182
0.007828
0.04501
0.007828
0.02544
0.048924
0.091977
0.043053
0.005871
0
0.023483
1
3,944
C
T
T
G
G
C
T
C
C
C
G
T
G
G
A
G
T
C
A
G
C
C
C
G
C
T
C
G
C
T
C
C
C
A
G
C
C
A
G
G
T
C
C
A
C
C
A
G
G
C
T
G
A
T
T
T
T
G
C
T
C
A
C
C
T
T
0.011742
0.011742
0.019569
0.003914
0.021526
0.039139
0.009785
0.013699
0.015656
0.046967
0.072407
0.005871
0.009785
0.023483
0.02544
0.041096
0.074364
0.07045
0.109589
0.031311
0.005871
0.035225
0.007828
0.046967
0.007828
0.02544
0.048924
0.091977
0.043053
0.005871
0
0.023483
1
3,945
G
T
A
T
C
T
A
C
T
G
T
T
T
C
A
G
G
T
G
A
G
C
A
A
A
A
T
C
A
G
C
C
T
G
G
T
G
G
A
C
C
T
G
G
C
T
G
G
G
A
G
C
G
A
G
C
G
G
G
C
T
G
A
C
T
G
0.011742
0.009785
0.019569
0.003914
0.017613
0.035225
0.011742
0.013699
0.015656
0.048924
0.07045
0.005871
0.009785
0.023483
0.02544
0.041096
0.072407
0.072407
0.113503
0.031311
0.005871
0.035225
0.007828
0.048924
0.007828
0.023483
0.050881
0.091977
0.046967
0.005871
0
0.021526
1
3,946
A
T
G
G
C
G
C
T
T
C
T
G
G
G
T
G
A
A
G
A
T
G
A
T
G
T
T
G
A
A
G
A
C
G
G
C
G
T
G
G
G
A
G
C
G
A
C
T
G
C
T
G
G
T
C
T
C
A
T
T
C
A
T
G
T
A
0.001957
0.009785
0.017613
0.005871
0.023483
0.052838
0.021526
0.023483
0.02544
0.023483
0.058708
0.003914
0.013699
0.02544
0.011742
0.07045
0.074364
0.084149
0.09002
0.027397
0.009785
0.031311
0.003914
0.035225
0.017613
0.033268
0.039139
0.088063
0.029354
0.007828
0.003914
0.035225
1