Datasets:
TabBioMed
/
vep_pathogenic_coding

Dataset card Data Studio Files
xet
 Community
row_idx
int64
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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C
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T
C
A
A
T
T
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G
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A
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A
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C
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T
T
G
G
G
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A
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C
C
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G
G
T
C
C
G
C
A
C
C
C
G
0.007828
0.011742
0.027397
0.005871
0.019569
0.041096
0.009785
0.011742
0.017613
0.048924
0.074364
0.009785
0.021526
0.02544
0.02544
0.041096
0.072407
0.066536
0.109589
0.023483
0.013699
0.011742
0.001957
0.052838
0.017613
0.023483
0.04501
0.07045
0.050881
0.005871
0.001957
0.033268
1
3,964
G
G
A
C
C
A
T
G
G
C
C
T
C
T
C
A
C
A
A
G
C
T
G
C
T
G
G
T
G
A
C
C
C
C
C
C
C
C
A
A
G
G
C
C
C
T
G
C
T
C
A
A
G
C
C
C
C
T
C
T
C
C
A
T
C
T
0.007828
0.011742
0.027397
0.005871
0.017613
0.043053
0.009785
0.009785
0.019569
0.048924
0.074364
0.009785
0.021526
0.02544
0.02544
0.041096
0.07045
0.066536
0.109589
0.023483
0.013699
0.011742
0.001957
0.054795
0.017613
0.023483
0.04501
0.07045
0.050881
0.005871
0.001957
0.033268
1
3,965
G
C
T
C
A
A
G
C
C
C
C
T
C
T
C
C
A
T
C
C
C
C
A
A
C
C
A
G
C
T
C
C
T
G
C
T
G
G
G
G
C
C
T
G
G
T
C
C
T
T
C
C
A
A
C
C
T
G
C
C
T
C
C
T
C
G
0.007828
0.011742
0.029354
0.005871
0.017613
0.048924
0.009785
0.009785
0.021526
0.041096
0.07045
0.013699
0.029354
0.035225
0.027397
0.043053
0.060665
0.068493
0.097847
0.02544
0.013699
0.013699
0.003914
0.048924
0.017613
0.023483
0.046967
0.062622
0.050881
0.007828
0.001957
0.033268
1
3,966
C
A
A
G
C
C
C
C
T
C
T
C
C
A
T
C
C
C
C
A
A
C
C
A
G
C
T
C
C
T
G
C
T
G
G
G
G
C
C
T
G
G
T
C
C
T
T
C
C
A
A
C
C
T
G
C
C
T
C
C
T
C
G
C
A
C
0.007828
0.011742
0.029354
0.005871
0.017613
0.048924
0.009785
0.009785
0.021526
0.041096
0.068493
0.013699
0.031311
0.035225
0.027397
0.043053
0.058708
0.068493
0.097847
0.02544
0.013699
0.013699
0.003914
0.048924
0.017613
0.023483
0.046967
0.062622
0.052838
0.007828
0.001957
0.033268
1
3,967
C
T
T
G
C
T
C
A
T
G
G
A
C
C
C
G
A
T
C
A
T
C
T
G
C
A
G
C
C
C
C
C
C
G
G
C
T
G
C
C
A
T
G
A
T
G
C
G
A
G
G
A
G
G
C
A
G
G
T
T
G
G
A
A
G
T
0.003914
0.013699
0.02544
0.005871
0.015656
0.052838
0.011742
0.015656
0.02544
0.035225
0.066536
0.011742
0.031311
0.037182
0.023483
0.04501
0.062622
0.076321
0.09589
0.021526
0.013699
0.011742
0.003914
0.050881
0.019569
0.02544
0.041096
0.056751
0.054795
0.011742
0
0.033268
1
3,968
C
T
T
G
C
T
C
A
T
G
G
A
C
C
C
G
A
T
C
A
T
C
T
G
C
A
G
C
C
C
C
C
C
G
G
C
T
G
C
C
A
T
G
A
T
G
C
G
A
G
G
A
G
G
C
A
G
G
T
T
G
G
A
A
G
G
0.003914
0.013699
0.02544
0.005871
0.015656
0.052838
0.011742
0.015656
0.02544
0.035225
0.066536
0.011742
0.031311
0.037182
0.023483
0.04501
0.062622
0.076321
0.09589
0.021526
0.013699
0.011742
0.003914
0.050881
0.019569
0.02544
0.041096
0.056751
0.054795
0.011742
0
0.033268
1
3,969
C
C
T
T
G
C
T
C
A
T
G
G
A
C
C
C
G
A
T
C
A
T
C
T
G
C
A
G
C
C
C
C
C
C
G
G
C
T
G
C
C
A
T
G
A
T
G
C
G
A
G
G
A
G
G
C
A
G
G
T
T
G
G
A
A
T
0.003914
0.013699
0.023483
0.005871
0.015656
0.052838
0.011742
0.015656
0.02544
0.035225
0.066536
0.011742
0.031311
0.037182
0.023483
0.04501
0.062622
0.078278
0.09589
0.021526
0.013699
0.011742
0.003914
0.050881
0.019569
0.02544
0.041096
0.056751
0.054795
0.011742
0
0.033268
1
3,970
T
A
T
C
C
T
T
G
C
T
C
A
T
G
G
A
C
C
C
G
A
T
C
A
T
C
T
G
C
A
G
C
C
C
C
C
C
G
G
C
T
G
C
C
A
T
G
A
T
G
C
G
A
G
G
A
G
G
C
A
G
G
T
T
G
T
0.003914
0.013699
0.023483
0.005871
0.015656
0.052838
0.011742
0.015656
0.02544
0.037182
0.064579
0.011742
0.031311
0.037182
0.023483
0.04501
0.062622
0.078278
0.09589
0.021526
0.013699
0.011742
0.003914
0.052838
0.019569
0.02544
0.039139
0.056751
0.054795
0.011742
0
0.033268
1
3,971
T
C
C
T
A
C
C
T
G
G
T
A
C
A
T
A
T
C
C
T
T
G
C
T
C
A
T
G
G
A
C
C
C
G
A
T
C
A
T
C
T
G
C
A
G
C
C
C
C
C
C
G
G
C
T
G
C
C
A
T
G
A
T
G
C
T
0.003914
0.013699
0.023483
0.005871
0.019569
0.052838
0.009785
0.017613
0.02544
0.035225
0.062622
0.011742
0.031311
0.037182
0.023483
0.046967
0.060665
0.076321
0.097847
0.021526
0.015656
0.011742
0.003914
0.052838
0.017613
0.027397
0.039139
0.054795
0.054795
0.011742
0
0.033268
1
3,972
C
T
G
G
A
A
C
A
C
G
T
A
C
T
G
G
A
T
G
C
C
T
T
C
C
T
T
G
A
T
C
T
C
G
T
C
C
A
T
G
A
T
C
T
G
C
A
T
G
C
G
G
G
T
G
G
T
A
T
A
G
G
G
T
G
T
0.003914
0.013699
0.019569
0.005871
0.019569
0.043053
0.011742
0.017613
0.021526
0.02544
0.072407
0.009785
0.037182
0.043053
0.021526
0.037182
0.058708
0.078278
0.099804
0.019569
0.017613
0.013699
0.005871
0.052838
0.017613
0.027397
0.033268
0.060665
0.066536
0.013699
0.001957
0.029354
1
3,973
T
G
G
G
T
T
C
C
T
G
G
T
C
T
G
G
A
A
C
A
C
G
T
A
C
T
G
G
A
T
G
C
C
T
T
C
C
T
T
G
A
T
C
T
C
G
T
C
C
A
T
G
A
T
C
T
G
C
A
T
G
C
G
G
G
G
0.003914
0.011742
0.021526
0.005871
0.019569
0.041096
0.011742
0.017613
0.021526
0.027397
0.072407
0.009785
0.035225
0.043053
0.019569
0.037182
0.060665
0.076321
0.099804
0.019569
0.017613
0.013699
0.005871
0.052838
0.017613
0.027397
0.035225
0.064579
0.064579
0.013699
0.001957
0.029354
1
3,974
G
T
C
C
C
G
A
G
C
C
A
G
A
G
A
T
G
A
C
C
A
G
T
G
T
G
A
G
T
G
G
G
T
T
C
C
T
G
G
T
C
T
G
G
A
A
C
A
C
G
T
A
C
T
G
G
A
T
G
C
C
T
T
C
C
A
0.003914
0.011742
0.023483
0.005871
0.019569
0.043053
0.013699
0.017613
0.021526
0.029354
0.068493
0.009785
0.035225
0.043053
0.017613
0.041096
0.054795
0.074364
0.101761
0.021526
0.017613
0.017613
0.005871
0.052838
0.017613
0.02544
0.033268
0.060665
0.060665
0.015656
0.003914
0.031311
1
3,975
A
T
T
G
A
C
C
A
G
G
G
C
G
G
C
C
T
C
C
A
G
G
G
C
A
C
A
G
T
G
T
C
C
C
G
A
G
C
C
A
G
A
G
A
T
G
A
C
C
A
G
T
G
T
G
A
G
T
G
G
G
T
T
C
C
G
0.003914
0.013699
0.023483
0.005871
0.023483
0.04501
0.015656
0.017613
0.021526
0.02544
0.07045
0.009785
0.033268
0.037182
0.019569
0.046967
0.056751
0.076321
0.09589
0.017613
0.017613
0.019569
0.005871
0.050881
0.019569
0.02544
0.033268
0.058708
0.060665
0.015656
0.003914
0.029354
1
3,976
G
C
A
C
A
T
T
G
A
C
C
A
G
G
G
C
G
G
C
C
T
C
C
A
G
G
G
C
A
C
A
G
T
G
T
C
C
C
G
A
G
C
C
A
G
A
G
A
T
G
A
C
C
A
G
T
G
T
G
A
G
T
G
G
G
C
0.003914
0.013699
0.023483
0.005871
0.023483
0.04501
0.015656
0.017613
0.021526
0.027397
0.07045
0.009785
0.033268
0.037182
0.019569
0.046967
0.054795
0.076321
0.097847
0.017613
0.017613
0.019569
0.005871
0.050881
0.019569
0.02544
0.029354
0.060665
0.060665
0.015656
0.003914
0.029354
1
3,977
C
A
C
A
C
T
G
G
T
C
A
T
C
T
C
T
G
G
C
T
C
G
G
G
A
C
A
C
T
G
T
G
C
C
C
T
G
G
A
G
G
C
C
G
C
C
C
T
G
G
T
C
A
A
T
G
T
G
C
T
G
G
A
G
C
A
0.003914
0.013699
0.023483
0.005871
0.023483
0.04501
0.015656
0.019569
0.019569
0.027397
0.07045
0.009785
0.027397
0.035225
0.019569
0.048924
0.056751
0.078278
0.097847
0.017613
0.017613
0.019569
0.005871
0.050881
0.019569
0.02544
0.031311
0.062622
0.060665
0.015656
0.003914
0.027397
1
3,978
A
T
T
G
G
C
C
C
C
A
A
C
C
A
G
G
A
A
G
G
A
G
T
C
C
C
C
A
G
G
C
T
C
C
A
G
C
A
C
A
T
T
G
A
C
C
A
G
G
G
C
G
G
C
C
T
C
C
A
G
G
G
C
A
C
T
0.003914
0.013699
0.021526
0.005871
0.023483
0.041096
0.015656
0.021526
0.019569
0.02544
0.072407
0.005871
0.02544
0.033268
0.017613
0.052838
0.056751
0.076321
0.097847
0.019569
0.017613
0.021526
0.005871
0.056751
0.019569
0.02544
0.031311
0.066536
0.060665
0.011742
0.003914
0.029354
1
3,979
A
T
G
C
G
C
T
C
C
C
C
G
A
T
G
T
C
C
A
C
G
G
C
T
C
G
C
T
G
C
C
C
C
C
A
A
A
T
G
C
C
A
T
T
G
G
C
C
C
C
A
A
C
C
A
G
G
A
A
G
G
A
G
T
C
A
0.003914
0.013699
0.021526
0.005871
0.023483
0.037182
0.015656
0.019569
0.019569
0.031311
0.076321
0.007828
0.027397
0.029354
0.017613
0.050881
0.064579
0.072407
0.088063
0.019569
0.017613
0.021526
0.005871
0.054795
0.019569
0.023483
0.037182
0.07045
0.060665
0.009785
0.003914
0.029354
1
3,980
C
T
A
T
G
C
G
C
T
C
C
C
C
G
A
T
G
T
C
C
A
C
G
G
C
T
C
G
C
T
G
C
C
C
C
C
A
A
A
T
G
C
C
A
T
T
G
G
C
C
C
C
A
A
C
C
A
G
G
A
A
G
G
A
G
A
0.003914
0.011742
0.021526
0.005871
0.023483
0.037182
0.015656
0.019569
0.019569
0.031311
0.076321
0.007828
0.031311
0.029354
0.017613
0.050881
0.064579
0.072407
0.088063
0.019569
0.017613
0.021526
0.005871
0.054795
0.017613
0.023483
0.037182
0.07045
0.060665
0.009785
0.003914
0.029354
1
3,981
T
G
T
A
G
T
G
G
C
C
T
C
C
A
G
G
G
T
C
C
T
T
G
G
T
C
A
T
C
G
G
G
T
G
C
A
C
T
C
G
G
G
C
T
C
C
T
G
G
G
T
G
C
A
G
G
A
C
A
G
A
G
T
G
G
G
0
0.007828
0.013699
0.009785
0.029354
0.048924
0.007828
0.021526
0.02544
0.043053
0.072407
0
0.011742
0.021526
0.015656
0.064579
0.076321
0.080235
0.09589
0.02544
0.003914
0.005871
0.011742
0.060665
0.011742
0.023483
0.041096
0.076321
0.050881
0.011742
0.003914
0.027397
1
3,982
C
C
C
G
G
C
C
C
T
G
A
C
C
C
C
C
A
C
C
C
C
G
G
G
T
C
C
C
C
T
A
C
C
T
C
C
T
C
C
A
C
C
T
C
C
T
G
C
A
G
T
G
T
G
T
A
G
T
G
G
C
C
T
C
C
A
0.001957
0.005871
0.011742
0.009785
0.029354
0.048924
0.005871
0.023483
0.023483
0.039139
0.080235
0
0.009785
0.021526
0.007828
0.062622
0.084149
0.078278
0.088063
0.02544
0.003914
0.003914
0.013699
0.056751
0.015656
0.02544
0.041096
0.084149
0.052838
0.013699
0.003914
0.027397
1
3,983
T
C
C
T
C
A
G
G
G
C
C
T
G
G
C
C
C
A
G
C
A
C
A
A
G
C
C
A
G
T
G
C
T
G
C
T
G
T
T
C
T
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A
A
C
C
C
A
C
G
G
G
G
A
G
T
C
G
T
C
C
A
C
C
G
C
0.011742
0.015656
0.023483
0
0.029354
0.043053
0.007828
0.015656
0.033268
0.054795
0.066536
0.003914
0.007828
0.023483
0.015656
0.048924
0.082192
0.076321
0.111546
0.017613
0.003914
0.005871
0.007828
0.056751
0.015656
0.02544
0.048924
0.066536
0.052838
0.005871
0.005871
0.015656
1
3,984
A
G
G
G
C
C
T
G
G
C
C
C
A
G
C
A
C
A
A
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C
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G
G
G
G
A
G
T
C
G
T
C
C
A
C
C
G
G
C
G
T
G
A
0.011742
0.013699
0.023483
0
0.027397
0.04501
0.007828
0.015656
0.033268
0.054795
0.066536
0.003914
0.007828
0.023483
0.015656
0.048924
0.082192
0.078278
0.111546
0.017613
0.003914
0.005871
0.007828
0.056751
0.015656
0.027397
0.048924
0.064579
0.052838
0.005871
0.005871
0.015656
1
3,985
G
C
C
T
G
G
C
C
C
A
G
C
A
C
A
A
G
C
C
A
G
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A
G
T
C
G
T
C
C
A
C
C
G
G
C
G
T
G
C
T
G
G
0.011742
0.013699
0.023483
0
0.027397
0.04501
0.007828
0.015656
0.033268
0.052838
0.066536
0.003914
0.007828
0.023483
0.015656
0.048924
0.080235
0.078278
0.113503
0.017613
0.003914
0.005871
0.007828
0.056751
0.015656
0.027397
0.048924
0.064579
0.054795
0.005871
0.005871
0.015656
1
3,986
A
A
G
G
G
G
C
T
G
C
A
G
C
A
C
G
C
C
G
G
T
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A
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C
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C
A
C
T
G
G
C
T
T
G
T
G
C
T
T
0.011742
0.013699
0.023483
0
0.027397
0.043053
0.007828
0.015656
0.033268
0.054795
0.068493
0.003914
0.007828
0.023483
0.015656
0.046967
0.084149
0.078278
0.107632
0.017613
0.003914
0.005871
0.007828
0.056751
0.015656
0.027397
0.048924
0.066536
0.054795
0.005871
0.005871
0.015656
1
3,987
A
A
G
G
G
G
C
T
G
C
A
G
C
A
C
G
C
C
G
G
T
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C
A
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C
A
G
C
A
C
T
G
G
C
T
T
G
T
G
C
T
G
0.011742
0.013699
0.023483
0
0.027397
0.043053
0.007828
0.015656
0.033268
0.054795
0.068493
0.003914
0.007828
0.023483
0.015656
0.046967
0.084149
0.078278
0.107632
0.017613
0.003914
0.005871
0.007828
0.056751
0.015656
0.027397
0.048924
0.066536
0.054795
0.005871
0.005871
0.015656
1
3,988
T
T
C
C
C
C
G
A
A
G
C
C
A
T
C
A
A
G
G
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G
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C
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G
T
G
G
G
T
T
A
A
G
A
A
C
A
G
C
A
T
0.011742
0.013699
0.023483
0
0.027397
0.04501
0.007828
0.015656
0.029354
0.056751
0.07045
0.003914
0.005871
0.021526
0.015656
0.046967
0.086106
0.078278
0.109589
0.017613
0.003914
0.005871
0.007828
0.054795
0.015656
0.027397
0.046967
0.068493
0.052838
0.005871
0.005871
0.017613
1
3,989
T
T
C
C
C
C
G
A
A
G
C
C
A
T
C
A
A
G
G
G
G
C
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G
T
G
G
G
T
T
A
A
G
A
A
C
A
G
C
A
G
0.011742
0.013699
0.023483
0
0.027397
0.04501
0.007828
0.015656
0.029354
0.056751
0.07045
0.003914
0.005871
0.021526
0.015656
0.046967
0.086106
0.078278
0.109589
0.017613
0.003914
0.005871
0.007828
0.054795
0.015656
0.027397
0.046967
0.068493
0.052838
0.005871
0.005871
0.017613
1
3,990
C
G
G
G
G
A
G
T
C
G
T
C
C
A
C
C
G
G
C
G
T
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A
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C
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G
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G
G
A
A
C
T
C
T
G
C
C
A
C
A
G
G
T
G
A
G
C
0.009785
0.011742
0.019569
0
0.02544
0.043053
0.007828
0.015656
0.027397
0.058708
0.068493
0.005871
0.005871
0.023483
0.011742
0.046967
0.084149
0.078278
0.11546
0.019569
0.005871
0.009785
0.009785
0.056751
0.013699
0.02544
0.046967
0.072407
0.050881
0.005871
0.005871
0.017613
1
3,991
G
T
C
C
A
C
C
G
C
C
C
T
G
G
G
G
C
C
A
G
G
C
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A
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C
C
A
T
C
A
A
G
G
G
G
C
T
G
C
A
G
C
T
0.005871
0.011742
0.015656
0
0.02544
0.04501
0.007828
0.017613
0.029354
0.054795
0.068493
0.005871
0.005871
0.023483
0.009785
0.050881
0.088063
0.080235
0.117417
0.015656
0.005871
0.009785
0.009785
0.056751
0.011742
0.027397
0.048924
0.072407
0.046967
0.005871
0.005871
0.019569
1
3,992
C
T
C
T
C
A
G
A
G
C
C
C
A
C
C
C
T
T
A
C
C
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C
C
C
G
C
C
C
A
G
G
G
A
T
G
C
C
A
C
C
G
G
0.011742
0.011742
0.033268
0.005871
0.015656
0.035225
0.007828
0.021526
0.023483
0.048924
0.078278
0
0.021526
0.019569
0.015656
0.039139
0.086106
0.078278
0.080235
0.019569
0.005871
0.017613
0.003914
0.048924
0.029354
0.015656
0.046967
0.074364
0.064579
0.013699
0.005871
0.019569
1
3,993
G
G
C
T
G
G
G
T
A
G
G
G
C
T
C
T
C
A
G
A
G
C
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G
T
A
A
A
G
G
G
G
G
G
T
C
C
C
G
C
C
C
A
T
0.011742
0.011742
0.029354
0.007828
0.017613
0.037182
0.007828
0.021526
0.019569
0.046967
0.076321
0
0.021526
0.021526
0.015656
0.041096
0.086106
0.080235
0.086106
0.019569
0.005871
0.017613
0.003914
0.04501
0.02544
0.017613
0.046967
0.074364
0.064579
0.013699
0.005871
0.019569
1
3,994
T
C
C
C
G
A
G
C
A
A
A
C
C
A
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C
C
A
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C
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G
G
C
T
C
C
C
A
G
A
A
G
G
C
C
C
T
G
A
A
A
0.009785
0.009785
0.017613
0.005871
0.021526
0.033268
0.017613
0.019569
0.021526
0.052838
0.080235
0.001957
0.017613
0.021526
0.011742
0.041096
0.076321
0.056751
0.086106
0.017613
0.017613
0.02544
0.017613
0.062622
0.017613
0.02544
0.043053
0.066536
0.054795
0.015656
0.003914
0.029354
1
3,995
C
C
G
A
G
C
A
A
A
C
C
A
C
C
C
A
T
C
T
A
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C
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C
T
C
C
C
A
G
A
A
G
G
C
C
C
T
G
A
A
C
G
A
0.009785
0.009785
0.017613
0.005871
0.021526
0.033268
0.017613
0.019569
0.021526
0.052838
0.080235
0.001957
0.017613
0.021526
0.011742
0.041096
0.076321
0.056751
0.084149
0.017613
0.017613
0.02544
0.017613
0.062622
0.017613
0.02544
0.043053
0.068493
0.054795
0.015656
0.003914
0.029354
1
3,996
A
C
C
A
C
C
C
A
T
C
T
A
C
A
G
G
C
A
T
C
G
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A
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A
G
G
C
C
C
T
G
A
A
C
G
C
C
C
C
T
C
C
A
C
0.009785
0.009785
0.017613
0.005871
0.019569
0.033268
0.017613
0.019569
0.021526
0.050881
0.078278
0.001957
0.017613
0.021526
0.011742
0.041096
0.074364
0.056751
0.084149
0.021526
0.019569
0.027397
0.017613
0.064579
0.017613
0.023483
0.043053
0.07045
0.052838
0.015656
0.003914
0.029354
1
3,997
C
C
A
C
C
C
A
T
C
T
A
C
A
G
G
C
A
T
C
G
A
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A
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T
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C
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A
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A
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G
G
C
C
C
T
G
A
A
C
G
C
C
C
C
T
C
C
A
G
T
0.009785
0.009785
0.017613
0.005871
0.019569
0.033268
0.017613
0.019569
0.021526
0.050881
0.080235
0.001957
0.017613
0.021526
0.011742
0.041096
0.072407
0.056751
0.084149
0.021526
0.019569
0.027397
0.017613
0.064579
0.017613
0.023483
0.043053
0.07045
0.052838
0.015656
0.003914
0.029354
1
3,998
G
A
T
G
A
G
C
G
A
G
G
T
C
C
C
T
G
G
A
G
G
G
G
C
G
T
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C
A
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G
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C
C
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G
G
G
A
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C
C
C
G
A
G
T
A
C
A
G
G
A
T
G
T
C
G
A
T
G
C
G
0.009785
0.009785
0.017613
0.005871
0.017613
0.031311
0.017613
0.019569
0.021526
0.048924
0.084149
0.001957
0.017613
0.021526
0.011742
0.039139
0.072407
0.052838
0.086106
0.021526
0.019569
0.027397
0.017613
0.066536
0.017613
0.021526
0.04501
0.074364
0.052838
0.015656
0.003914
0.029354
1
3,999
C
C
C
T
G
A
A
C
G
C
C
C
C
T
C
C
A
G
G
G
A
C
C
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C
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C
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A
G
T
G
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A
A
G
G
C
C
A
A
G
T
G
A
G
T
G
A
C
C
C
A
C
C
0.005871
0.007828
0.017613
0.005871
0.019569
0.033268
0.017613
0.023483
0.021526
0.043053
0.080235
0.001957
0.017613
0.021526
0.011742
0.046967
0.074364
0.056751
0.086106
0.021526
0.019569
0.023483
0.015656
0.064579
0.017613
0.023483
0.050881
0.07045
0.054795
0.015656
0.001957
0.027397
1
4,000
A
C
A
G
C
C
C
C
A
G
A
A
G
T
T
G
G
C
C
A
G
C
C
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C
T
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G
A
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G
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C
C
A
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G
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A
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G
A
A
G
G
G
C
T
T
C
G
T
C
T
T
G
C
G
G
G
G
0.011742
0.011742
0.031311
0.009785
0.015656
0.027397
0.009785
0.02544
0.039139
0.046967
0.056751
0
0.013699
0.023483
0.019569
0.033268
0.080235
0.076321
0.109589
0.017613
0.013699
0.017613
0.005871
0.050881
0.033268
0.027397
0.031311
0.082192
0.039139
0.005871
0
0.033268
1
4,001
C
A
A
G
A
C
G
A
A
G
C
C
C
T
T
C
T
C
C
T
T
C
T
A
C
C
T
G
G
A
C
A
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C
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C
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C
A
A
C
T
T
C
T
G
G
G
G
C
T
G
T
G
A
C
G
C
0.011742
0.011742
0.031311
0.009785
0.015656
0.027397
0.009785
0.02544
0.039139
0.04501
0.058708
0
0.013699
0.023483
0.019569
0.033268
0.080235
0.074364
0.107632
0.017613
0.013699
0.017613
0.005871
0.050881
0.033268
0.027397
0.033268
0.084149
0.039139
0.005871
0
0.033268
1
4,002
T
G
G
A
C
A
T
C
A
A
G
T
G
G
C
T
G
G
C
C
A
A
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T
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G
G
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C
C
A
G
G
A
T
G
T
G
A
G
G
C
C
T
G
G
C
A
C
0.011742
0.011742
0.031311
0.009785
0.013699
0.029354
0.009785
0.02544
0.039139
0.043053
0.056751
0
0.013699
0.027397
0.017613
0.037182
0.076321
0.074364
0.109589
0.017613
0.013699
0.017613
0.005871
0.050881
0.035225
0.02544
0.035225
0.082192
0.037182
0.005871
0
0.035225
1
4,003
G
G
A
C
C
A
A
G
C
C
C
C
C
T
C
G
T
G
T
C
T
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C
C
A
G
G
T
A
C
C
A
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C
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A
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G
T
C
A
T
C
A
G
C
C
T
G
T
A
C
A
G
C
C
T
A
0.005871
0.011742
0.015656
0.007828
0.041096
0.029354
0.009785
0.013699
0.048924
0.043053
0.066536
0.003914
0.015656
0.023483
0.015656
0.041096
0.091977
0.062622
0.086106
0.02544
0.007828
0.011742
0.003914
0.060665
0.017613
0.02544
0.052838
0.078278
0.046967
0.017613
0.001957
0.015656
1
4,004
C
C
C
A
T
G
C
A
C
C
T
G
T
T
C
C
G
C
A
A
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G
T
A
C
A
G
G
C
T
G
A
T
G
A
C
G
G
G
G
A
G
0.005871
0.011742
0.015656
0.009785
0.043053
0.029354
0.005871
0.011742
0.046967
0.043053
0.064579
0.003914
0.019569
0.029354
0.017613
0.035225
0.09002
0.062622
0.093933
0.02544
0.007828
0.011742
0.003914
0.056751
0.017613
0.02544
0.052838
0.076321
0.046967
0.017613
0.001957
0.015656
1
4,005
C
T
G
T
C
T
C
C
T
C
C
T
G
T
G
G
A
G
T
G
C
A
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A
G
G
G
C
C
A
G
G
C
T
C
T
C
T
C
T
C
A
G
G
0.005871
0.013699
0.015656
0.011742
0.043053
0.031311
0.005871
0.011742
0.046967
0.041096
0.064579
0.003914
0.019569
0.027397
0.019569
0.037182
0.09002
0.060665
0.093933
0.02544
0.007828
0.011742
0.001957
0.056751
0.019569
0.02544
0.052838
0.068493
0.050881
0.015656
0.001957
0.017613
1
4,006
C
T
G
C
C
C
A
C
C
A
G
C
G
C
C
A
T
C
T
C
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G
C
G
C
C
A
G
C
A
C
C
G
C
G
A
G
G
C
C
G
C
0.005871
0.009785
0.02544
0.003914
0.021526
0.033268
0.005871
0.017613
0.04501
0.031311
0.076321
0.001957
0.009785
0.019569
0.011742
0.039139
0.084149
0.064579
0.113503
0.023483
0.009785
0.027397
0.003914
0.056751
0.023483
0.023483
0.052838
0.088063
0.043053
0.005871
0.003914
0.017613
1
4,007
C
T
G
G
C
G
C
C
A
G
C
A
C
C
G
C
G
A
G
G
C
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G
C
A
G
G
C
A
C
T
G
G
G
G
C
T
G
C
A
G
C
C
0.005871
0.009785
0.02544
0.003914
0.021526
0.031311
0.007828
0.017613
0.037182
0.035225
0.074364
0.001957
0.015656
0.021526
0.011742
0.041096
0.082192
0.060665
0.103718
0.031311
0.009785
0.029354
0.003914
0.052838
0.023483
0.021526
0.052838
0.09002
0.04501
0.005871
0.003914
0.021526
1
4,008
C
A
C
G
C
A
C
T
G
A
G
C
C
A
G
G
C
C
C
C
T
C
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C
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A
G
T
C
A
C
C
A
C
T
G
T
G
G
C
T
G
T
A
C
C
0.013699
0.005871
0.029354
0.005871
0.021526
0.035225
0.017613
0.017613
0.037182
0.041096
0.068493
0.003914
0.023483
0.019569
0.015656
0.046967
0.062622
0.052838
0.078278
0.037182
0.015656
0.019569
0.009785
0.062622
0.021526
0.029354
0.037182
0.072407
0.050881
0.009785
0.003914
0.033268
1
4,009
A
G
C
C
A
G
G
C
C
C
C
T
C
C
T
G
C
A
G
G
C
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G
G
C
T
G
T
A
C
C
C
G
C
T
G
G
C
T
T
0.013699
0.005871
0.029354
0.003914
0.021526
0.035225
0.017613
0.017613
0.037182
0.041096
0.068493
0.003914
0.023483
0.019569
0.015656
0.048924
0.062622
0.054795
0.080235
0.035225
0.013699
0.019569
0.007828
0.064579
0.021526
0.027397
0.037182
0.074364
0.052838
0.009785
0.001957
0.033268
1
4,010
T
C
T
C
A
C
C
T
T
C
C
C
C
G
T
G
G
A
G
G
G
C
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G
T
C
G
A
A
G
T
G
G
T
C
T
A
T
G
A
C
G
T
T
0.017613
0.005871
0.031311
0.005871
0.019569
0.041096
0.015656
0.019569
0.031311
0.043053
0.07045
0.009785
0.017613
0.017613
0.017613
0.046967
0.064579
0.058708
0.086106
0.02544
0.015656
0.019569
0.007828
0.060665
0.019569
0.027397
0.037182
0.066536
0.046967
0.015656
0.005871
0.031311
1
4,011
C
T
C
C
G
T
C
A
C
G
C
G
G
T
C
C
A
C
A
T
T
C
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G
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G
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C
A
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C
A
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C
C
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A
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C
A
G
G
C
C
G
A
T
C
C
G
C
A
G
C
A
C
C
T
T
0.007828
0.005871
0.013699
0.003914
0.031311
0.041096
0.011742
0.013699
0.017613
0.046967
0.088063
0
0.009785
0.013699
0.011742
0.050881
0.107632
0.060665
0.093933
0.02544
0.005871
0.019569
0
0.04501
0.011742
0.037182
0.058708
0.086106
0.046967
0
0
0.033268
1
4,012
T
G
T
G
G
A
C
C
G
C
G
T
G
A
C
G
G
A
G
G
C
C
C
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A
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G
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C
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C
C
C
C
A
A
G
A
A
G
A
A
G
C
T
G
T
G
A
C
A
0.013699
0.009785
0.017613
0.003914
0.029354
0.041096
0.009785
0.019569
0.013699
0.043053
0.084149
0
0.009785
0.013699
0.015656
0.052838
0.105675
0.068493
0.09002
0.021526
0.005871
0.021526
0
0.037182
0.013699
0.037182
0.056751
0.086106
0.04501
0
0
0.033268
1
4,013
C
G
C
C
A
G
C
T
G
T
A
A
C
T
G
G
A
G
G
A
A
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G
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G
C
C
C
A
C
G
T
C
T
G
G
C
T
G
T
T
T
A
C
T
0.078278
0.04501
0.035225
0.021526
0.048924
0.035225
0.02544
0.02544
0.033268
0.04501
0.031311
0.007828
0.009785
0.019569
0.035225
0.043053
0.048924
0.052838
0.02544
0.021526
0.013699
0.017613
0.019569
0.031311
0.04501
0.031311
0.017613
0.029354
0.043053
0.013699
0.021526
0.027397
1
4,014
C
T
T
G
G
C
A
C
C
G
G
T
G
A
A
G
G
C
C
A
C
A
C
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A
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A
A
A
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T
G
C
G
T
A
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C
T
G
T
C
C
A
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G
A
C
G
A
G
G
G
T
C
A
C
G
C
C
C
T
G
G
C
T
0.04501
0.02544
0.033268
0.035225
0.037182
0.029354
0.013699
0.023483
0.041096
0.031311
0.054795
0.031311
0.033268
0.02544
0.031311
0.039139
0.048924
0.039139
0.023483
0.009785
0.015656
0.019569
0.023483
0.04501
0.027397
0.023483
0.027397
0.043053
0.031311
0.015656
0.035225
0.041096
1
4,015
A
C
C
A
G
G
G
C
T
C
A
G
G
A
G
C
A
T
C
C
T
C
T
T
T
T
T
C
A
G
G
C
C
G
T
T
A
A
T
T
A
A
G
G
A
A
A
A
G
T
T
G
A
G
C
C
A
G
G
G
C
G
T
G
A
T
0.039139
0.017613
0.033268
0.035225
0.033268
0.029354
0.013699
0.023483
0.033268
0.037182
0.060665
0.027397
0.031311
0.023483
0.02544
0.041096
0.054795
0.043053
0.027397
0.011742
0.017613
0.019569
0.017613
0.046967
0.023483
0.02544
0.029354
0.048924
0.037182
0.015656
0.037182
0.039139
1
4,016
C
T
G
T
A
G
C
A
A
G
G
T
G
C
T
G
C
T
G
A
G
G
C
C
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G
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C
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G
G
T
G
T
C
C
C
A
C
A
T
C
C
T
C
A
G
G
T
G
A
G
G
T
G
G
0.035225
0.017613
0.021526
0.017613
0.043053
0.031311
0.013699
0.019569
0.035225
0.04501
0.048924
0.007828
0.02544
0.031311
0.029354
0.056751
0.060665
0.056751
0.054795
0.017613
0.015656
0.015656
0.009785
0.056751
0.023483
0.02544
0.043053
0.048924
0.043053
0.007828
0.003914
0.037182
1
4,017
G
G
G
T
G
G
C
A
G
C
G
T
C
C
C
C
G
T
C
T
T
T
G
A
C
G
A
G
A
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C
A
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C
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C
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C
C
A
C
T
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C
C
C
G
C
A
T
G
A
A
C
C
G
G
G
T
C
C
T
C
A
G
0.005871
0.017613
0.017613
0.009785
0.027397
0.039139
0.029354
0.015656
0.023483
0.037182
0.062622
0
0.015656
0.02544
0.017613
0.052838
0.07045
0.066536
0.091977
0.027397
0.007828
0.029354
0.009785
0.043053
0.019569
0.033268
0.043053
0.066536
0.050881
0.007828
0.005871
0.029354
1
4,018
G
A
A
G
G
C
C
T
C
C
G
C
C
G
T
C
A
C
A
T
T
G
A
G
G
T
G
C
A
G
G
T
T
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C
C
A
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C
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C
C
T
G
G
A
G
G
G
A
C
A
A
G
G
G
C
A
C
A
T
G
G
G
T
C
0
0.009785
0.027397
0.001957
0.013699
0.02544
0.02544
0.011742
0.023483
0.062622
0.074364
0
0.009785
0.019569
0.023483
0.02544
0.07045
0.050881
0.125245
0.033268
0.009785
0.017613
0.007828
0.064579
0.013699
0.027397
0.046967
0.080235
0.054795
0.013699
0.001957
0.027397
1
4,019
C
C
C
T
C
C
A
G
G
A
G
A
T
G
G
T
A
A
C
C
T
G
C
A
C
C
T
C
A
A
T
G
T
G
A
C
G
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C
G
G
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G
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C
C
T
T
C
A
G
C
C
C
C
T
C
G
C
T
C
C
T
G
G
C
0
0.009785
0.027397
0.001957
0.013699
0.02544
0.02544
0.013699
0.021526
0.062622
0.076321
0
0.007828
0.017613
0.023483
0.027397
0.076321
0.052838
0.117417
0.029354
0.009785
0.017613
0.007828
0.064579
0.013699
0.027397
0.052838
0.078278
0.054795
0.013699
0.001957
0.027397
1
4,020
C
T
G
G
C
A
G
A
A
A
G
A
T
G
C
G
G
A
A
C
G
C
A
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A
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A
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C
T
C
A
C
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A
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A
A
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T
C
T
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G
T
T
T
T
T
A
G
G
T
A
A
T
A
T
T
T
G
C
A
T
0.084149
0.031311
0.041096
0.056751
0.027397
0.02544
0.011742
0.037182
0.052838
0.015656
0.02544
0.037182
0.033268
0.041096
0.037182
0.017613
0.037182
0.02544
0.021526
0.011742
0.003914
0.007828
0.031311
0.021526
0.04501
0.02544
0.031311
0.019569
0.019569
0.027397
0.046967
0.048924
1
4,021
C
C
T
T
T
T
C
T
A
A
T
G
A
A
T
A
G
G
T
T
T
T
G
A
T
G
G
C
A
C
T
T
T
A
T
T
T
G
A
C
T
A
C
T
T
T
A
A
T
G
G
T
T
A
T
G
A
A
G
A
T
T
T
A
A
C
0.119374
0.037182
0.035225
0.068493
0.048924
0.017613
0.005871
0.039139
0.048924
0.017613
0.015656
0.052838
0.031311
0.039139
0.039139
0.02544
0.031311
0.023483
0.007828
0
0.001957
0
0.039139
0.015656
0.035225
0.027397
0.021526
0.003914
0.017613
0.023483
0.068493
0.041096
1
4,022
A
T
C
T
T
A
A
A
A
T
T
C
T
A
A
G
A
T
A
A
T
C
C
T
C
T
T
G
T
A
T
T
C
T
C
T
G
T
T
T
A
G
C
A
T
G
T
C
C
A
A
C
A
A
A
T
C
T
A
A
C
T
T
T
C
A
0.111546
0.031311
0.035225
0.068493
0.046967
0.017613
0.007828
0.041096
0.041096
0.017613
0.015656
0.064579
0.027397
0.048924
0.031311
0.029354
0.027397
0.023483
0.009785
0
0.001957
0.001957
0.035225
0.017613
0.043053
0.023483
0.015656
0.003914
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4,023
T
G
G
T
G
A
C
C
A
T
G
A
T
C
C
T
G
A
G
A
C
T
T
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G
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A
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A
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C
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A
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C
A
A
A
A
G
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C
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G
G
C
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G
G
A
A
T
A
T
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1
4,024
T
T
C
T
C
T
C
T
A
C
A
C
A
G
T
C
T
T
A
T
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G
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C
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4,025
A
A
G
A
C
C
G
A
G
T
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A
A
G
A
A
A
G
G
T
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G
T
C
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C
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A
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C
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4,026
C
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C
C
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C
A
C
C
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G
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T
T
G
G
T
C
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G
G
C
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T
A
A
T
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C
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G
G
C
C
T
T
T
G
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1
4,027
C
T
T
C
C
G
T
G
G
G
C
A
G
C
C
G
C
T
T
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C
A
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C
A
T
T
C
C
A
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G
A
C
A
C
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T
G
G
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4,028
G
T
T
A
G
C
G
C
C
T
T
T
C
A
C
A
G
G
T
A
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A
A
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G
C
A
A
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C
C
A
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A
A
C
A
G
G
C
T
G
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0
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4,029
T
C
C
A
C
A
C
A
C
C
A
G
C
C
C
T
A
G
T
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C
C
A
T
G
T
G
A
C
C
C
G
G
T
T
G
G
T
C
C
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1
4,030
C
T
T
T
T
G
A
A
C
T
G
G
T
G
G
C
A
G
A
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T
C
A
G
G
A
A
G
A
C
G
T
G
C
T
G
C
T
T
C
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1
4,031
C
C
A
C
C
A
A
T
G
C
T
T
A
A
T
C
C
A
A
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C
G
A
G
T
G
T
C
T
C
A
G
C
A
C
C
C
T
G
T
C
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1
4,032
A
T
C
C
C
A
C
C
A
A
T
G
C
T
T
A
A
T
C
C
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C
T
G
C
G
A
G
T
G
T
C
T
C
A
G
C
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C
C
C
C
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1
4,033
G
C
A
G
A
T
T
G
G
C
T
A
T
G
A
T
G
T
G
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G
C
T
C
C
A
C
A
A
T
A
A
T
C
G
G
A
A
A
C
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1
4,034
C
G
C
G
G
T
A
A
T
G
T
G
T
T
T
T
T
C
C
A
G
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G
C
A
G
T
G
A
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A
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T
G
T
C
T
T
C
A
G
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1
4,035
T
G
T
C
C
T
G
C
T
C
C
A
C
T
T
G
A
C
G
A
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A
G
G
G
G
C
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C
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C
T
C
C
T
C
T
T
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1
4,036
A
A
A
G
A
G
G
T
T
G
T
T
G
A
C
T
T
G
G
C
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G
G
C
C
C
G
G
C
T
C
T
T
G
G
C
T
G
C
A
C
T
0.031311
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0.023483
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1
4,037
A
G
A
G
A
A
G
C
T
C
T
G
C
A
T
T
A
A
G
G
T
C
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A
C
C
A
A
A
G
A
T
A
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A
G
G
C
T
A
T
G
C
0.113503
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0
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0.068493
0.04501
1
4,038
C
A
G
T
G
A
C
C
G
A
G
T
G
T
T
C
C
A
T
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C
T
G
G
A
A
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A
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C
A
A
C
A
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C
A
C
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0.039139
0.02544
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0.023483
0.021526
0.046967
1
4,039
T
C
C
T
C
T
C
T
G
C
G
T
T
T
T
C
A
C
T
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T
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G
G
A
G
C
A
A
C
T
T
C
G
A
G
G
C
A
T
T
G
C
0.048924
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0.013699
0.013699
0.037182
1
4,040
A
A
G
T
G
T
C
A
C
T
C
G
C
A
A
T
G
G
A
C
G
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C
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G
G
C
T
C
T
G
A
T
C
C
T
C
G
T
T
T
A
C
C
C
0.084149
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0.052838
0.04501
1
4,041
C
G
G
C
T
T
C
C
T
G
A
G
T
A
C
A
T
C
T
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A
C
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T
G
A
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A
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G
0.052838
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0.027397
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0.023483
0.021526
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0.015656
0.019569
0.041096
1
4,042
T
C
C
T
C
A
G
G
T
C
A
G
C
A
A
A
A
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T
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A
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G
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C
T
0.039139
0.021526
0.050881
0.021526
0.023483
0.035225
0.011742
0.029354
0.058708
0.033268
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0.035225
0.037182
0.054795
0.039139
0.048924
0.011742
0.009785
0.017613
0.009785
0.048924
0.035225
0.033268
0.04501
0.033268
0.023483
0.007828
0.021526
0.050881
1
4,043
C
A
T
T
G
T
T
C
T
T
A
A
C
C
T
G
A
T
T
T
T
T
G
G
G
G
T
T
A
T
C
A
T
T
G
A
C
A
C
T
T
T
T
G
C
T
G
A
C
C
T
G
A
G
G
A
G
T
G
A
G
A
A
G
C
A
0.041096
0.021526
0.050881
0.019569
0.023483
0.035225
0.011742
0.027397
0.058708
0.033268
0.04501
0.013699
0.02544
0.031311
0.033268
0.037182
0.054795
0.039139
0.048924
0.011742
0.007828
0.015656
0.009785
0.048924
0.037182
0.031311
0.043053
0.037182
0.023483
0.007828
0.023483
0.050881
1
4,044
A
A
C
C
T
G
A
T
T
T
T
T
G
G
G
G
T
T
A
T
C
A
T
T
G
A
C
A
C
T
T
T
T
G
C
T
G
A
C
C
T
G
A
G
G
A
G
T
G
A
G
A
A
G
C
A
G
A
A
G
A
A
G
G
A
G
0.041096
0.021526
0.052838
0.019569
0.021526
0.035225
0.011742
0.027397
0.058708
0.035225
0.043053
0.013699
0.02544
0.031311
0.031311
0.037182
0.056751
0.041096
0.046967
0.011742
0.007828
0.015656
0.009785
0.046967
0.039139
0.029354
0.04501
0.037182
0.02544
0.007828
0.023483
0.048924
1
4,045
C
T
G
C
T
C
A
T
A
G
T
T
G
G
A
A
T
C
T
T
T
T
C
C
A
A
T
T
C
T
C
T
C
C
T
G
T
C
C
T
G
C
A
C
A
T
T
A
A
A
A
C
A
A
G
A
A
A
C
A
C
A
C
A
C
T
0.062622
0.027397
0.041096
0.052838
0.064579
0.019569
0.011742
0.037182
0.033268
0.031311
0.023483
0.037182
0.023483
0.039139
0.046967
0.054795
0.031311
0.043053
0.009785
0.003914
0.005871
0.005871
0.027397
0.02544
0.039139
0.017613
0.031311
0.017613
0.033268
0.031311
0.037182
0.033268
1
4,046
C
T
T
A
C
T
G
T
T
T
G
G
G
T
C
T
A
C
G
T
T
T
T
C
A
C
A
G
A
G
C
T
C
G
G
T
C
T
T
T
G
C
C
T
C
A
C
C
G
T
T
G
G
G
T
C
T
G
T
C
A
C
T
G
G
T
0.048924
0.031311
0.052838
0.017613
0.054795
0.029354
0.013699
0.029354
0.048924
0.046967
0.027397
0.013699
0.021526
0.041096
0.041096
0.046967
0.041096
0.043053
0.023483
0.011742
0.011742
0.009785
0.021526
0.037182
0.048924
0.021526
0.031311
0.02544
0.027397
0.02544
0.013699
0.041096
1