row_idx
int64
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string
f_1_ref__31
string
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string
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string
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string
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string
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string
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string
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string
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string
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f_65_alt
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
30,476
T
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C
G
G
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C
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A
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C
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T
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G
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30,479
G
A
G
C
C
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G
C
C
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G
C
G
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C
T
G
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C
A
C
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C
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T
C
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T
G
G
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C
T
T
A
C
T
C
C
A
C
C
T
C
T
C
T
T
G
C
T
C
C
T
C
T
C
T
G
C
A
G
T
0.027397
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30,480
G
A
G
A
T
G
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A
G
C
A
G
A
G
G
C
C
T
C
A
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A
C
A
C
A
A
G
T
T
C
C
T
G
G
G
C
C
C
A
G
A
A
A
T
C
C
C
A
G
C
C
A
T
G
A
G
C
C
A
C
C
A
C
C
C
0.023483
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0
30,481
G
C
C
C
A
C
A
G
T
A
C
C
C
A
G
G
C
T
C
T
C
C
C
C
T
T
A
C
A
A
C
A
T
T
G
T
C
A
G
C
A
C
C
C
C
T
C
C
C
T
C
C
C
G
A
T
C
C
T
G
T
G
G
G
T
C
0.031311
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0
30,482
G
C
T
G
C
G
T
C
C
G
C
A
G
G
A
G
C
C
G
G
C
C
C
G
A
A
A
G
C
C
T
C
C
G
C
A
C
A
C
G
C
T
G
T
G
G
C
T
G
C
C
G
A
A
G
C
C
C
C
C
G
G
T
G
A
G
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0
30,483
G
C
C
G
G
G
C
C
G
C
G
G
C
C
C
G
C
A
G
G
C
C
G
A
G
A
T
G
C
A
G
C
T
G
A
A
G
G
C
G
C
G
C
C
C
A
C
C
A
A
A
T
C
C
T
G
A
T
C
C
G
C
A
G
G
G
0.015656
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0.011742
0.029354
0
30,484
G
G
C
C
T
A
C
A
G
A
G
G
T
G
C
A
A
G
T
A
G
T
G
A
A
C
G
C
C
T
G
A
C
G
C
C
C
C
G
A
C
C
A
C
T
G
T
G
C
T
C
T
C
C
A
T
T
C
G
G
A
C
G
T
C
T
0.02544
0.019569
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0.02544
0
30,485
C
C
T
G
T
G
G
A
G
G
G
G
G
C
T
C
C
T
G
C
G
G
C
C
A
G
G
G
G
A
G
G
C
A
T
T
A
A
G
T
G
G
C
C
C
A
A
A
A
G
A
G
A
G
C
C
A
G
G
G
G
A
G
C
C
T
0.019569
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0.003914
0.023483
0
30,486
T
G
C
T
G
G
A
G
A
C
A
A
A
G
C
T
G
C
A
G
T
T
C
T
A
C
C
A
A
A
A
C
C
G
C
G
A
G
T
G
C
T
G
C
C
A
G
A
G
T
A
A
C
C
T
G
G
A
G
C
C
C
C
T
G
T
0.019569
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0.013699
0.023483
0
30,487
C
G
C
C
T
T
C
C
T
G
T
A
C
G
A
G
C
C
A
T
G
T
G
G
G
G
T
C
A
G
C
A
C
G
C
C
T
G
T
C
C
T
C
A
G
C
A
C
T
G
G
C
G
T
C
C
T
C
A
G
G
A
G
C
A
T
0.009785
0.007828
0.019569
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0.039139
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0.064579
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0.04501
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0.058708
0.013699
0.003914
0.029354
0
30,488
G
T
G
C
T
G
A
G
G
A
C
A
G
G
C
G
T
G
C
T
G
A
C
C
C
C
A
C
A
T
G
G
C
T
C
G
T
A
C
A
G
G
A
A
G
G
C
G
C
C
T
T
T
G
G
A
G
C
T
G
C
T
C
A
C
G
0.009785
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0.021526
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0.011742
0.052838
0.074364
0.066536
0.084149
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0.019569
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0.017613
0.021526
0.046967
0.062622
0.054795
0.013699
0.003914
0.027397
0
30,489
G
A
A
G
C
C
C
C
T
G
C
T
T
A
C
C
T
T
G
T
C
G
A
T
G
A
A
G
G
A
G
G
C
G
A
A
C
T
T
A
T
T
G
T
T
G
A
G
G
G
T
C
T
T
G
A
T
C
T
G
C
T
C
G
C
T
0.019569
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0.033268
0.046967
0.050881
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0.007828
0.035225
0
30,490
G
A
G
G
C
T
T
C
A
G
T
G
G
C
C
C
C
A
G
C
T
T
C
C
C
C
G
T
G
T
G
T
C
C
C
C
C
T
G
G
A
G
G
C
A
T
C
C
A
A
G
A
G
G
T
C
A
C
T
G
T
C
A
A
C
G
0.015656
0.019569
0.039139
0.017613
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0.035225
0.001957
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0.048924
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0.007828
0.029354
0
30,491
G
C
G
C
A
G
G
T
C
G
T
C
C
C
C
A
T
G
T
C
T
G
C
C
T
G
C
T
G
T
G
A
T
C
T
G
C
A
G
C
T
C
C
T
C
G
T
A
C
T
G
C
A
G
C
C
C
A
G
A
G
G
T
G
G
C
0.043053
0.021526
0.035225
0.031311
0.029354
0.033268
0.009785
0.035225
0.054795
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0.050881
0.043053
0.02544
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0.009785
0.007828
0.023483
0.046967
0.037182
0.029354
0.041096
0.019569
0.035225
0.023483
0.023483
0.050881
0
30,492
G
C
A
A
A
G
G
T
A
C
T
T
A
C
A
G
A
C
G
T
T
G
A
C
T
T
G
T
C
C
A
A
C
G
C
C
T
T
C
G
C
C
A
T
T
C
A
G
C
C
T
G
T
G
G
A
G
A
G
G
A
A
C
A
C
T
0.011742
0.015656
0.04501
0.011742
0.029354
0.035225
0.011742
0.041096
0.037182
0.046967
0.060665
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0.021526
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0.017613
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0.035225
0.029354
0.039139
0.050881
0.052838
0.019569
0.009785
0.029354
0
30,493
T
G
T
T
G
G
A
G
G
C
G
G
C
A
G
T
T
C
C
A
C
C
A
T
C
A
A
G
T
A
C
A
C
C
A
C
C
A
C
C
T
C
C
T
C
C
T
C
C
A
G
C
A
G
G
A
A
G
A
G
C
T
A
T
A
G
0.007828
0.011742
0.029354
0.005871
0.023483
0.041096
0.005871
0.031311
0.048924
0.060665
0.056751
0.013699
0.019569
0.027397
0.019569
0.052838
0.072407
0.076321
0.035225
0.009785
0.003914
0.007828
0.021526
0.076321
0.017613
0.023483
0.041096
0.050881
0.050881
0.013699
0.009785
0.033268
0
30,494
C
A
G
A
G
C
G
G
C
T
G
A
C
C
C
C
A
G
G
G
A
G
C
C
T
G
G
C
T
G
A
G
T
T
G
G
C
A
C
T
G
A
A
A
C
C
C
C
G
G
C
G
G
C
T
G
C
T
G
C
T
G
T
G
G
C
0.013699
0.013699
0.021526
0.005871
0.017613
0.031311
0.003914
0.021526
0.037182
0.080235
0.043053
0.015656
0.019569
0.029354
0.017613
0.04501
0.080235
0.088063
0.052838
0.027397
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0.015656
0.011742
0.068493
0.019569
0.011742
0.041096
0.074364
0.054795
0.003914
0.003914
0.02544
0
30,495
G
A
A
G
C
C
A
G
A
G
C
C
C
C
C
C
A
C
A
C
T
G
A
G
C
C
C
A
C
C
A
C
C
T
A
G
G
C
C
G
A
C
A
C
C
C
C
C
A
C
T
G
C
T
G
C
T
G
G
A
G
T
A
G
T
T
0.021526
0.013699
0.035225
0.009785
0.017613
0.035225
0.001957
0.041096
0.035225
0.060665
0.046967
0.009785
0.015656
0.019569
0.033268
0.048924
0.066536
0.072407
0.048924
0.023483
0.007828
0.009785
0.02544
0.054795
0.019569
0.021526
0.056751
0.060665
0.046967
0.011742
0.005871
0.021526
0
30,496
C
C
C
A
C
T
G
C
T
G
C
T
G
G
A
G
T
A
G
T
A
G
C
T
T
C
C
A
C
T
G
C
T
A
C
C
T
C
C
G
G
C
A
A
G
A
C
C
T
C
C
A
C
C
G
A
G
G
C
C
G
C
C
G
C
C
0.019569
0.013699
0.037182
0.015656
0.021526
0.035225
0.001957
0.039139
0.033268
0.058708
0.04501
0.007828
0.013699
0.017613
0.033268
0.048924
0.066536
0.068493
0.050881
0.027397
0.007828
0.009785
0.023483
0.050881
0.021526
0.021526
0.054795
0.060665
0.04501
0.013699
0.013699
0.021526
0
30,497
T
G
G
A
C
C
C
T
G
C
T
G
C
A
G
G
A
G
C
A
G
G
G
C
A
C
C
A
A
G
A
C
T
G
T
G
A
G
G
C
A
G
A
A
C
C
T
G
G
A
G
C
C
G
T
T
G
T
T
C
G
A
G
C
A
C
0.02544
0.035225
0.039139
0.001957
0.031311
0.04501
0.007828
0.033268
0.041096
0.031311
0.066536
0.009785
0.017613
0.019569
0.031311
0.043053
0.066536
0.058708
0.062622
0.009785
0.005871
0.003914
0.015656
0.050881
0.039139
0.023483
0.04501
0.033268
0.056751
0.015656
0.005871
0.027397
0
30,498
C
G
G
T
T
C
C
T
G
G
A
G
C
A
G
C
A
G
A
A
C
A
A
G
G
T
T
C
T
G
G
A
C
A
C
C
A
A
G
T
G
G
A
C
C
C
T
G
C
T
G
C
A
G
G
A
G
C
A
G
G
G
C
A
C
A
0.02544
0.035225
0.035225
0.001957
0.035225
0.043053
0.007828
0.037182
0.043053
0.033268
0.066536
0.007828
0.017613
0.015656
0.029354
0.050881
0.068493
0.052838
0.058708
0.009785
0.005871
0.003914
0.021526
0.050881
0.037182
0.02544
0.048924
0.031311
0.054795
0.011742
0.005871
0.027397
0
30,499
G
A
C
T
C
T
G
G
T
T
G
A
C
A
G
T
G
A
C
C
T
C
T
T
G
G
A
T
A
C
C
T
C
C
A
G
G
A
G
G
G
C
A
G
A
C
A
G
G
A
A
A
G
C
C
A
G
G
G
C
C
A
C
C
G
T
0.048924
0.021526
0.039139
0.013699
0.023483
0.054795
0.001957
0.023483
0.035225
0.052838
0.046967
0.019569
0.027397
0.013699
0.04501
0.046967
0.04501
0.07045
0.029354
0.02544
0.019569
0.011742
0.015656
0.056751
0.021526
0.019569
0.031311
0.04501
0.04501
0.015656
0.007828
0.02544
0
30,500
A
A
T
G
A
G
G
C
G
G
G
G
C
C
C
G
G
G
G
C
A
G
T
C
T
T
C
T
C
T
A
C
C
G
A
C
T
G
G
T
T
T
T
C
T
T
G
G
A
G
G
G
T
G
C
A
C
T
C
A
G
G
C
T
G
T
0.007828
0.013699
0.027397
0.009785
0.035225
0.037182
0.003914
0.029354
0.031311
0.054795
0.048924
0.007828
0.019569
0.02544
0.019569
0.056751
0.076321
0.076321
0.062622
0.027397
0.005871
0.009785
0.013699
0.048924
0.02544
0.019569
0.043053
0.064579
0.052838
0.015656
0.005871
0.023483
0
30,501
A
G
C
C
A
T
C
A
T
C
A
G
C
A
G
C
A
C
C
A
G
T
G
G
C
G
G
C
A
G
T
G
T
C
T
A
T
G
G
C
T
T
C
C
G
G
C
C
C
A
G
C
A
T
G
G
T
C
A
G
C
G
G
T
G
G
0.015656
0.013699
0.033268
0.013699
0.031311
0.02544
0.003914
0.027397
0.043053
0.056751
0.04501
0.009785
0.015656
0.027397
0.023483
0.043053
0.068493
0.060665
0.07045
0.031311
0.007828
0.011742
0.011742
0.058708
0.027397
0.019569
0.048924
0.064579
0.046967
0.011742
0.009785
0.021526
0
30,502
C
T
C
T
C
G
C
T
C
C
T
G
G
G
C
A
C
G
C
A
C
T
T
T
C
T
G
G
A
T
C
T
C
G
G
G
G
T
C
C
A
G
C
T
C
C
A
C
G
T
T
G
A
G
G
G
G
G
G
C
C
A
G
G
A
T
0.019569
0.029354
0.039139
0.009785
0.050881
0.027397
0.009785
0.021526
0.041096
0.037182
0.058708
0.005871
0.023483
0.023483
0.039139
0.043053
0.054795
0.060665
0.060665
0.021526
0.011742
0.007828
0.011742
0.052838
0.029354
0.017613
0.023483
0.068493
0.04501
0.019569
0.009785
0.02544
0
30,503
C
T
C
G
G
G
T
G
G
A
G
C
C
T
G
C
T
C
A
C
C
T
C
T
T
C
T
T
A
T
A
G
T
C
C
T
C
C
A
C
C
A
G
A
T
C
C
C
T
C
A
T
G
C
T
T
C
T
C
A
G
C
T
C
C
A
0.019569
0.031311
0.029354
0.009785
0.029354
0.04501
0.003914
0.021526
0.041096
0.056751
0.060665
0.013699
0.02544
0.029354
0.023483
0.035225
0.074364
0.050881
0.054795
0.011742
0.005871
0.005871
0.02544
0.050881
0.039139
0.02544
0.04501
0.02544
0.054795
0.007828
0.007828
0.039139
0
30,504
T
C
T
A
G
A
A
A
C
C
A
A
G
T
G
G
G
A
G
C
T
G
C
T
G
C
A
G
C
A
G
C
T
G
G
A
C
C
T
G
A
A
C
A
A
C
T
G
C
A
A
G
A
A
G
A
A
C
C
T
G
G
A
G
C
A
0.027397
0.027397
0.029354
0.017613
0.041096
0.043053
0.003914
0.023483
0.04501
0.048924
0.050881
0.009785
0.021526
0.039139
0.035225
0.041096
0.064579
0.058708
0.043053
0.007828
0.003914
0.003914
0.02544
0.048924
0.031311
0.031311
0.048924
0.023483
0.050881
0.011742
0.007828
0.033268
0
30,505
G
G
G
T
T
C
C
A
G
G
T
A
C
G
C
T
T
C
C
T
A
G
A
G
C
A
G
C
A
G
A
A
C
C
A
G
G
T
T
C
T
A
G
A
A
A
C
C
A
A
G
T
G
G
G
A
G
C
T
G
C
T
G
C
A
G
0.023483
0.031311
0.035225
0.013699
0.041096
0.041096
0.003914
0.029354
0.046967
0.052838
0.050881
0.005871
0.021526
0.033268
0.037182
0.043053
0.066536
0.054795
0.037182
0.007828
0.003914
0.003914
0.023483
0.052838
0.037182
0.031311
0.043053
0.021526
0.050881
0.009785
0.003914
0.041096
0
30,506
G
T
G
C
T
G
G
A
T
C
T
G
T
T
T
G
C
C
C
C
T
C
A
G
T
G
T
G
C
C
G
A
T
C
T
G
G
A
G
A
C
G
G
C
C
A
T
C
G
C
C
G
A
C
G
C
T
G
A
A
C
A
G
C
G
A
0.021526
0.023483
0.033268
0
0.017613
0.027397
0.011742
0.027397
0.039139
0.04501
0.064579
0.007828
0.039139
0.023483
0.027397
0.029354
0.07045
0.054795
0.052838
0.023483
0.013699
0.021526
0.009785
0.062622
0.021526
0.021526
0.043053
0.054795
0.060665
0.009785
0.007828
0.033268
0
30,507
G
C
T
G
A
T
G
T
A
G
C
C
C
T
C
A
T
A
A
A
T
G
G
G
C
T
C
C
A
G
G
T
T
C
T
T
C
C
T
G
C
A
G
T
T
G
T
T
C
A
A
G
T
C
C
A
G
C
T
G
C
T
G
T
A
C
0.033268
0.029354
0.027397
0.017613
0.023483
0.033268
0.003914
0.019569
0.043053
0.043053
0.058708
0.009785
0.037182
0.033268
0.033268
0.021526
0.07045
0.058708
0.060665
0.015656
0.007828
0.003914
0.011742
0.054795
0.039139
0.019569
0.043053
0.031311
0.068493
0.009785
0.003914
0.033268
0
30,508
C
A
A
G
A
G
C
C
T
C
C
T
G
G
C
C
C
C
G
C
T
C
A
A
C
G
T
G
G
A
G
A
T
G
G
A
C
C
C
C
G
A
G
A
T
C
C
A
G
A
G
G
G
T
G
C
G
C
G
C
C
C
A
G
G
C
0.013699
0.015656
0.029354
0.011742
0.02544
0.02544
0.015656
0.013699
0.019569
0.050881
0.052838
0.003914
0.015656
0.021526
0.033268
0.041096
0.046967
0.050881
0.076321
0.052838
0.023483
0.056751
0.001957
0.056751
0.013699
0.019569
0.04501
0.09002
0.041096
0.003914
0.009785
0.021526
0
30,509
C
C
C
G
G
C
G
C
T
G
C
C
G
A
A
G
G
C
G
G
T
G
C
C
C
A
C
G
A
A
G
C
C
G
C
C
C
A
G
G
C
G
G
C
C
G
C
C
G
C
C
C
C
G
C
C
G
T
G
C
A
G
C
A
G
T
0.005871
0.015656
0.031311
0.005871
0.015656
0.02544
0.013699
0.009785
0.019569
0.052838
0.052838
0
0.017613
0.019569
0.033268
0.027397
0.048924
0.041096
0.080235
0.072407
0.021526
0.076321
0.001957
0.054795
0.017613
0.019569
0.046967
0.097847
0.043053
0.003914
0.001957
0.02544
0
30,510
T
A
C
C
T
C
C
T
G
A
C
C
C
C
A
G
T
G
T
G
C
C
A
A
C
C
T
G
G
A
G
A
C
G
G
C
C
A
T
C
G
C
T
G
A
C
G
C
C
G
A
G
C
A
G
C
G
G
G
G
G
G
A
C
T
T
0.019569
0.015656
0.031311
0.013699
0.017613
0.031311
0.009785
0.023483
0.029354
0.062622
0.064579
0.007828
0.019569
0.02544
0.031311
0.029354
0.07045
0.060665
0.056751
0.011742
0.013699
0.027397
0.007828
0.07045
0.017613
0.027397
0.04501
0.04501
0.060665
0.009785
0.009785
0.033268
0
30,511
A
T
A
G
C
C
T
C
C
T
G
C
C
C
A
C
C
C
A
C
T
G
C
C
A
C
T
G
G
C
C
A
C
A
T
T
G
A
A
A
G
A
G
A
T
G
C
T
C
C
G
G
G
C
A
C
C
C
C
C
C
A
G
G
C
T
0.017613
0.015656
0.033268
0.009785
0.02544
0.027397
0.011742
0.021526
0.017613
0.064579
0.050881
0.005871
0.027397
0.023483
0.029354
0.046967
0.07045
0.058708
0.078278
0.035225
0.009785
0.013699
0.007828
0.043053
0.021526
0.015656
0.048924
0.074364
0.043053
0.007828
0.005871
0.037182
0
30,512
G
G
A
A
G
A
T
G
G
G
C
T
C
C
A
G
G
T
T
G
A
T
G
G
G
G
C
G
G
G
T
G
C
C
A
A
C
A
T
T
C
A
T
T
T
G
T
T
G
T
A
G
C
A
G
C
T
C
C
C
A
T
T
T
G
T
0.019569
0.023483
0.035225
0.023483
0.031311
0.029354
0.003914
0.02544
0.052838
0.052838
0.035225
0.017613
0.035225
0.04501
0.027397
0.039139
0.07045
0.060665
0.035225
0.005871
0.011742
0.009785
0.007828
0.054795
0.043053
0.017613
0.04501
0.033268
0.041096
0.009785
0.011742
0.04501
0
30,513
T
G
G
T
T
A
C
T
C
C
G
G
A
A
T
A
A
G
T
G
G
T
A
G
A
A
A
C
A
A
A
C
T
T
C
A
C
G
C
T
G
G
A
A
C
T
G
C
C
A
C
C
A
G
A
G
G
A
C
T
T
G
A
C
A
C
0.029354
0.021526
0.02544
0.013699
0.015656
0.02544
0.007828
0.02544
0.04501
0.078278
0.029354
0.019569
0.019569
0.02544
0.015656
0.023483
0.058708
0.058708
0.04501
0.054795
0.005871
0.021526
0.035225
0.058708
0.027397
0.013699
0.029354
0.07045
0.048924
0.015656
0.015656
0.019569
0
30,514
G
C
C
G
C
A
G
C
C
G
C
T
G
C
C
A
T
A
A
C
C
G
C
C
T
C
C
A
C
T
C
C
T
G
C
C
T
C
G
T
G
C
C
C
C
G
C
C
T
C
C
G
C
G
G
T
A
G
C
T
T
C
T
T
C
C
0.009785
0.013699
0.017613
0.005871
0.015656
0.035225
0.02544
0.011742
0.02544
0.037182
0.064579
0.003914
0.027397
0.015656
0.015656
0.048924
0.046967
0.035225
0.066536
0.066536
0.013699
0.066536
0.013699
0.060665
0.015656
0.013699
0.050881
0.080235
0.052838
0.011742
0.005871
0.02544
0
30,515
C
C
T
T
T
G
G
C
C
C
C
A
G
T
A
C
C
A
G
G
A
G
C
T
C
C
A
G
A
T
C
A
C
G
G
C
A
G
G
G
A
G
A
C
A
T
G
G
A
G
A
C
G
A
C
C
T
G
A
A
G
A
A
C
A
T
0.011742
0.017613
0.021526
0.015656
0.033268
0.039139
0.011742
0.023483
0.04501
0.048924
0.048924
0.013699
0.027397
0.041096
0.027397
0.046967
0.074364
0.056751
0.052838
0.011742
0.007828
0.003914
0.013699
0.058708
0.017613
0.02544
0.068493
0.031311
0.04501
0.017613
0.009785
0.031311
0
30,516
T
G
C
A
A
T
C
A
G
T
T
C
A
T
A
C
T
G
G
G
T
C
C
G
C
A
C
T
G
C
A
T
C
G
A
T
G
A
T
G
C
T
G
T
C
C
A
G
G
T
C
C
A
G
G
G
A
A
C
G
G
T
T
A
T
T
0.031311
0.019569
0.035225
0.043053
0.043053
0.023483
0.009785
0.019569
0.068493
0.029354
0.041096
0.02544
0.02544
0.035225
0.031311
0.02544
0.058708
0.04501
0.039139
0.009785
0.013699
0.013699
0.011742
0.050881
0.041096
0.029354
0.037182
0.033268
0.039139
0.019569
0.02544
0.02544
0
30,517
A
C
T
G
A
G
C
A
A
A
T
C
C
A
C
C
T
G
C
C
T
C
C
G
C
A
G
G
T
C
A
C
C
G
A
T
G
T
A
G
T
T
C
T
C
C
A
A
G
A
G
G
G
G
C
T
C
C
A
G
G
T
T
G
T
A
0.023483
0.031311
0.02544
0.009785
0.039139
0.035225
0.003914
0.027397
0.039139
0.041096
0.058708
0.005871
0.021526
0.037182
0.035225
0.039139
0.07045
0.048924
0.050881
0.015656
0.007828
0.015656
0.009785
0.058708
0.02544
0.021526
0.068493
0.033268
0.054795
0.013699
0.005871
0.02544
0
30,518
A
G
G
C
A
G
C
A
C
C
A
G
T
A
T
C
C
G
C
T
T
C
T
C
C
C
A
G
A
C
C
A
C
G
A
G
C
T
C
A
A
G
C
C
A
G
C
A
T
A
G
C
T
C
C
A
C
C
A
A
G
T
G
A
T
T
0.013699
0.015656
0.027397
0.009785
0.009785
0.037182
0.003914
0.039139
0.035225
0.074364
0.037182
0.017613
0.023483
0.035225
0.017613
0.043053
0.084149
0.082192
0.043053
0.013699
0.003914
0.009785
0.023483
0.048924
0.031311
0.017613
0.062622
0.039139
0.056751
0.013699
0.003914
0.02544
0
30,519
C
T
T
G
C
T
C
C
T
C
T
G
G
G
C
A
A
T
C
T
C
C
T
C
A
T
A
C
T
G
G
G
C
G
C
G
G
A
C
C
T
C
G
G
C
A
A
T
G
A
T
G
C
T
G
C
C
C
A
G
G
T
C
C
A
T
0.027397
0.023483
0.027397
0.015656
0.037182
0.031311
0.007828
0.017613
0.033268
0.048924
0.058708
0.009785
0.04501
0.046967
0.037182
0.02544
0.068493
0.066536
0.035225
0.007828
0.003914
0.011742
0.019569
0.043053
0.019569
0.029354
0.037182
0.039139
0.062622
0.015656
0.009785
0.037182
0
30,520
C
T
G
G
G
C
A
A
T
C
T
C
C
T
C
A
T
A
C
T
G
G
G
C
G
C
G
G
A
C
C
T
C
G
G
C
A
A
T
G
A
T
G
C
T
G
C
C
C
A
G
G
T
C
C
A
G
G
C
A
G
C
G
G
T
T
0.027397
0.027397
0.027397
0.015656
0.041096
0.031311
0.007828
0.017613
0.033268
0.046967
0.056751
0.009785
0.04501
0.046967
0.039139
0.02544
0.066536
0.064579
0.035225
0.007828
0.003914
0.011742
0.019569
0.041096
0.019569
0.031311
0.037182
0.037182
0.062622
0.013699
0.011742
0.037182
0
30,521
T
A
C
C
T
T
C
T
T
G
A
G
C
C
C
C
A
C
A
A
A
C
T
C
A
T
T
C
T
C
T
G
C
G
G
C
A
G
T
G
C
G
T
T
T
G
T
T
G
A
T
T
T
C
A
T
C
T
T
C
A
T
A
C
C
T
0.074364
0.023483
0.039139
0.033268
0.046967
0.029354
0.007828
0.023483
0.041096
0.039139
0.046967
0.023483
0.011742
0.04501
0.023483
0.046967
0.054795
0.039139
0.029354
0.001957
0.001957
0.007828
0.009785
0.04501
0.048924
0.019569
0.039139
0.023483
0.035225
0.017613
0.023483
0.046967
0
30,522
C
C
A
T
G
A
C
C
A
T
C
C
C
A
C
C
T
G
C
T
T
C
T
T
G
A
C
A
C
C
C
T
C
G
A
T
C
T
C
T
G
C
C
C
G
C
A
G
C
C
T
C
T
G
G
A
T
C
A
T
T
C
T
G
T
T
0.021526
0.017613
0.035225
0.023483
0.02544
0.029354
0.005871
0.017613
0.046967
0.043053
0.058708
0.013699
0.043053
0.04501
0.031311
0.021526
0.068493
0.050881
0.064579
0.003914
0.005871
0.003914
0.017613
0.046967
0.031311
0.02544
0.048924
0.033268
0.050881
0.013699
0.013699
0.041096
0
30,523
G
A
C
T
G
C
C
A
A
A
G
C
C
A
C
C
T
G
C
T
C
C
G
C
T
C
C
G
G
A
A
G
C
C
A
T
A
G
G
C
C
C
C
T
C
C
G
C
C
A
G
C
T
C
C
C
C
C
A
G
A
G
T
G
G
G
0.029354
0.011742
0.041096
0.009785
0.02544
0.037182
0.001957
0.011742
0.035225
0.080235
0.046967
0.015656
0.011742
0.02544
0.035225
0.041096
0.058708
0.082192
0.04501
0.031311
0.003914
0.021526
0.007828
0.066536
0.015656
0.013699
0.039139
0.066536
0.054795
0.007828
0.011742
0.013699
0
30,524
T
C
T
C
C
A
G
G
A
C
C
T
T
A
T
T
C
T
G
T
T
G
C
T
C
T
A
A
G
A
A
C
T
G
C
A
C
C
T
G
T
G
T
T
G
A
T
A
A
A
G
G
C
A
C
C
A
G
C
C
A
A
G
T
G
C
0.013699
0.02544
0.039139
0.013699
0.037182
0.043053
0.007828
0.02544
0.037182
0.037182
0.062622
0.013699
0.013699
0.037182
0.041096
0.043053
0.058708
0.064579
0.048924
0.003914
0.007828
0.007828
0.023483
0.043053
0.027397
0.033268
0.04501
0.050881
0.037182
0.011742
0.009785
0.035225
0
30,525
G
G
T
G
C
A
G
G
G
C
C
A
C
A
T
C
C
A
G
A
T
C
C
C
C
A
A
G
C
T
T
C
T
T
C
T
G
A
G
C
A
T
C
C
T
T
G
A
G
T
G
C
C
A
G
C
T
C
C
C
C
A
C
G
C
C
0.009785
0.005871
0.039139
0.015656
0.017613
0.029354
0.011742
0.011742
0.054795
0.060665
0.050881
0.005871
0.029354
0.031311
0.02544
0.031311
0.07045
0.062622
0.072407
0.021526
0.005871
0.011742
0.005871
0.064579
0.033268
0.02544
0.04501
0.046967
0.058708
0.007828
0.003914
0.033268
0
30,526
G
T
G
T
C
A
G
C
A
G
C
T
G
C
A
G
A
C
G
G
C
C
A
T
T
G
C
G
G
A
A
G
C
G
G
A
G
C
A
G
C
G
T
G
G
G
G
A
G
C
T
G
G
C
A
C
T
C
A
A
G
G
A
T
G
T
0.009785
0.007828
0.043053
0.015656
0.017613
0.029354
0.011742
0.017613
0.046967
0.060665
0.052838
0.005871
0.029354
0.031311
0.02544
0.031311
0.074364
0.060665
0.068493
0.017613
0.005871
0.011742
0.007828
0.054795
0.033268
0.02544
0.048924
0.046967
0.054795
0.009785
0.007828
0.035225
0
30,527
T
A
T
C
T
C
T
G
T
C
A
G
T
G
T
G
G
C
C
G
G
A
G
G
G
G
C
C
T
T
G
T
T
G
G
G
G
C
G
G
G
C
T
C
T
G
G
G
G
G
G
C
T
T
T
G
G
C
T
T
T
G
G
C
A
C
0.015656
0.017613
0.033268
0.003914
0.031311
0.023483
0.007828
0.027397
0.031311
0.050881
0.054795
0.011742
0.017613
0.013699
0.039139
0.039139
0.066536
0.060665
0.09002
0.029354
0.015656
0.017613
0.003914
0.060665
0.011742
0.029354
0.039139
0.076321
0.04501
0.003914
0.003914
0.027397
0
30,528
C
A
A
G
G
C
C
T
C
A
G
C
C
T
C
A
G
C
C
T
T
G
C
T
G
C
T
C
C
G
G
G
C
G
A
T
C
T
C
C
T
C
G
T
A
C
C
G
G
G
C
G
C
G
G
A
C
C
T
C
A
G
T
G
A
T
0.009785
0.013699
0.029354
0.011742
0.017613
0.046967
0.007828
0.021526
0.027397
0.048924
0.058708
0.009785
0.027397
0.04501
0.021526
0.029354
0.068493
0.078278
0.068493
0.013699
0.011742
0.013699
0.013699
0.04501
0.027397
0.033268
0.037182
0.04501
0.060665
0.017613
0.005871
0.033268
0
30,529
A
T
G
C
T
T
C
A
A
G
A
A
G
T
A
G
A
G
G
T
A
C
T
C
T
C
T
C
A
G
A
G
C
C
T
C
C
A
G
C
T
T
G
C
C
C
T
C
C
A
A
C
T
C
C
A
T
C
T
T
G
C
T
C
A
T
0.023483
0.02544
0.046967
0.027397
0.02544
0.031311
0.003914
0.029354
0.058708
0.029354
0.060665
0.005871
0.021526
0.037182
0.041096
0.027397
0.050881
0.056751
0.058708
0
0
0
0.013699
0.066536
0.046967
0.023483
0.027397
0.033268
0.052838
0.015656
0.011742
0.046967
0
30,530
G
G
G
C
A
T
C
C
A
A
G
A
A
G
T
G
A
C
C
A
T
C
A
A
C
C
A
G
A
A
T
C
T
G
C
T
G
A
C
C
C
C
A
C
T
G
A
A
G
A
T
T
G
A
G
A
T
C
G
A
T
C
C
C
C
C
0.015656
0.023483
0.04501
0.013699
0.013699
0.035225
0.003914
0.029354
0.037182
0.050881
0.062622
0.001957
0.021526
0.009785
0.035225
0.029354
0.072407
0.056751
0.09002
0.013699
0.009785
0.017613
0.007828
0.054795
0.037182
0.021526
0.039139
0.04501
0.050881
0.007828
0.009785
0.037182
0
30,531
C
C
A
G
G
T
A
C
T
C
C
C
A
C
G
A
G
A
G
C
C
T
T
C
C
A
G
G
C
A
C
C
C
C
C
C
A
A
A
G
G
A
A
T
T
A
A
G
G
C
T
C
C
T
G
C
T
G
C
T
G
A
A
G
C
T
0.011742
0.017613
0.031311
0.011742
0.023483
0.037182
0.011742
0.021526
0.04501
0.046967
0.054795
0.001957
0.023483
0.013699
0.027397
0.035225
0.082192
0.054795
0.099804
0.019569
0.011742
0.019569
0.001957
0.052838
0.027397
0.029354
0.043053
0.050881
0.039139
0.009785
0.005871
0.037182
0
30,532
A
G
C
C
G
C
C
C
C
T
G
C
T
G
C
T
G
A
A
G
C
C
T
C
C
C
C
T
G
C
T
G
C
G
G
C
C
C
C
T
T
G
A
G
C
G
A
G
C
A
G
A
A
C
A
G
G
C
T
G
A
G
C
G
A
T
0.009785
0.009785
0.033268
0.009785
0.02544
0.029354
0.013699
0.029354
0.048924
0.052838
0.04501
0.003914
0.021526
0.011742
0.023483
0.037182
0.088063
0.054795
0.093933
0.019569
0.011742
0.019569
0.001957
0.054795
0.021526
0.037182
0.043053
0.052838
0.037182
0.013699
0.007828
0.037182
0
30,533
A
G
G
C
T
G
C
A
G
T
C
A
G
T
T
C
T
G
A
T
T
G
T
G
C
C
A
C
T
A
C
A
T
T
C
C
A
G
C
C
T
G
G
C
T
G
A
C
A
G
A
G
C
A
A
G
A
C
C
C
T
G
T
C
T
C
0.054795
0.013699
0.027397
0.02544
0.02544
0.035225
0.009785
0.027397
0.037182
0.043053
0.056751
0.003914
0.031311
0.037182
0.035225
0.035225
0.072407
0.064579
0.027397
0.001957
0.003914
0.007828
0.021526
0.041096
0.019569
0.029354
0.041096
0.056751
0.031311
0.019569
0.013699
0.048924
0
30,534
A
G
G
G
T
T
G
G
C
G
C
T
C
C
C
G
C
T
C
C
C
C
T
C
C
C
A
G
C
C
C
T
T
C
T
G
T
C
C
T
C
T
G
C
A
G
A
C
G
C
A
G
A
C
G
G
G
C
C
C
C
G
C
C
T
C
0.009785
0.009785
0.037182
0.003914
0.027397
0.021526
0.005871
0.015656
0.060665
0.054795
0.072407
0.009785
0.021526
0.015656
0.017613
0.029354
0.084149
0.052838
0.062622
0.017613
0.007828
0.027397
0.011742
0.07045
0.027397
0.027397
0.043053
0.068493
0.052838
0.003914
0.005871
0.023483
0
30,535
C
T
A
C
T
C
C
T
T
C
C
T
G
A
G
A
G
A
G
G
C
T
G
T
G
C
C
T
G
G
G
A
C
C
C
T
T
C
G
T
G
C
C
A
G
A
C
G
A
G
G
T
G
A
G
G
C
C
T
T
C
A
T
C
T
T
0.033268
0.021526
0.04501
0.015656
0.027397
0.027397
0.005871
0.019569
0.048924
0.043053
0.074364
0.017613
0.027397
0.029354
0.015656
0.029354
0.078278
0.04501
0.035225
0.009785
0.005871
0.001957
0.019569
0.04501
0.041096
0.017613
0.043053
0.064579
0.037182
0.011742
0.02544
0.037182
0
30,536
G
G
A
G
A
A
C
C
C
T
G
A
A
A
T
G
T
T
T
G
A
G
G
A
T
G
A
C
T
C
C
T
C
G
C
A
G
C
C
T
G
G
T
C
C
C
C
A
C
C
C
C
A
A
T
G
C
C
T
C
T
A
G
C
G
T
0.021526
0.017613
0.029354
0.013699
0.017613
0.029354
0.001957
0.017613
0.050881
0.031311
0.084149
0
0.021526
0.031311
0.019569
0.021526
0.062622
0.052838
0.103718
0.009785
0.007828
0.011742
0.015656
0.076321
0.027397
0.02544
0.027397
0.062622
0.054795
0.003914
0.011742
0.037182
0
30,537
T
C
C
C
G
G
G
C
C
C
A
C
C
C
T
G
C
A
C
C
T
G
C
T
C
T
T
G
C
C
C
C
C
G
C
T
G
C
C
C
T
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C
C
T
G
T
C
C
T
C
C
C
T
T
G
A
C
T
T
G
T
C
C
C
T
0.005871
0.011742
0.033268
0.003914
0.033268
0.02544
0.005871
0.015656
0.023483
0.074364
0.076321
0.005871
0.003914
0.02544
0.027397
0.029354
0.09002
0.050881
0.093933
0.017613
0.003914
0.011742
0.017613
0.048924
0.013699
0.031311
0.066536
0.066536
0.052838
0.007828
0.007828
0.017613
0
30,538
T
T
C
A
A
C
A
T
C
A
T
C
T
G
T
G
A
C
C
T
C
C
T
G
G
A
G
C
T
G
A
G
C
C
C
C
G
A
G
G
A
G
A
C
A
C
C
A
G
C
C
G
G
G
G
C
C
T
G
G
G
C
A
C
G
A
0.009785
0.017613
0.02544
0
0.021526
0.039139
0.007828
0.023483
0.039139
0.072407
0.074364
0.001957
0.005871
0.027397
0.019569
0.033268
0.082192
0.054795
0.048924
0.015656
0.011742
0.011742
0.021526
0.080235
0.017613
0.023483
0.052838
0.060665
0.04501
0.017613
0.005871
0.031311
0
30,539
A
T
T
C
A
C
C
A
G
T
G
G
C
T
A
C
G
G
G
G
G
C
T
G
A
G
G
G
G
A
G
C
C
G
G
A
G
C
C
G
A
G
G
A
C
C
A
A
G
G
T
C
C
T
T
G
T
C
A
C
T
C
T
C
C
T
0.027397
0.019569
0.048924
0.017613
0.029354
0.027397
0.001957
0.023483
0.052838
0.058708
0.056751
0.009785
0.015656
0.023483
0.02544
0.027397
0.066536
0.052838
0.060665
0.013699
0.005871
0.001957
0.015656
0.060665
0.046967
0.023483
0.031311
0.041096
0.056751
0.011742
0.013699
0.031311
0
30,540
C
A
C
G
G
G
C
C
A
T
G
C
T
C
A
A
G
G
C
A
C
C
C
T
C
T
C
G
G
G
T
G
T
G
G
T
G
A
C
C
G
C
C
A
G
T
G
A
A
G
C
C
G
C
T
T
G
C
A
T
G
G
A
C
G
C
0.031311
0.019569
0.048924
0.019569
0.029354
0.035225
0.005871
0.033268
0.043053
0.033268
0.052838
0.023483
0.015656
0.029354
0.031311
0.041096
0.052838
0.052838
0.050881
0.015656
0.007828
0.009785
0.023483
0.037182
0.039139
0.027397
0.035225
0.054795
0.031311
0.015656
0.015656
0.037182
0
30,541
C
T
T
C
C
T
T
C
A
A
G
T
G
C
A
A
A
C
C
G
A
G
C
T
C
A
G
C
C
A
G
C
C
T
G
C
C
G
T
T
A
A
C
T
T
C
A
G
C
C
A
C
T
T
C
C
A
G
G
C
G
G
C
T
G
T
0.019569
0.017613
0.041096
0.009785
0.011742
0.033268
0.003914
0.031311
0.039139
0.056751
0.068493
0.001957
0.017613
0.02544
0.02544
0.033268
0.060665
0.058708
0.060665
0.015656
0.009785
0.009785
0.017613
0.074364
0.033268
0.011742
0.043053
0.054795
0.054795
0.017613
0.009785
0.031311
0
30,542
C
G
G
T
T
C
A
G
C
C
C
A
C
T
C
C
G
T
G
G
C
C
A
A
G
G
A
G
C
C
G
G
C
C
A
A
A
G
G
A
G
C
C
G
C
C
C
C
C
A
G
T
A
G
G
T
A
G
C
A
G
C
G
G
C
T
0.037182
0.021526
0.033268
0.009785
0.015656
0.019569
0.021526
0.019569
0.023483
0.039139
0.066536
0.011742
0.007828
0.005871
0.029354
0.017613
0.027397
0.029354
0.09589
0.060665
0.039139
0.035225
0.009785
0.078278
0.023483
0.02544
0.019569
0.078278
0.056751
0.011742
0.013699
0.015656
0
30,543
A
A
C
G
T
G
A
A
T
T
T
T
T
T
T
C
A
T
C
C
A
T
G
G
G
T
A
G
A
C
T
A
T
G
G
G
T
T
G
C
T
T
G
C
T
G
G
C
G
G
C
G
C
T
G
G
A
G
G
G
A
T
G
G
T
C
0.029354
0.009785
0.015656
0.02544
0.007828
0.031311
0.013699
0.017613
0.031311
0.054795
0.050881
0.009785
0.009785
0.017613
0.015656
0.02544
0.048924
0.060665
0.097847
0.039139
0.021526
0.046967
0.02544
0.066536
0.019569
0.015656
0.027397
0.07045
0.046967
0.019569
0.015656
0.011742
0
30,544
C
A
A
G
A
C
A
A
A
G
A
C
A
C
C
T
G
A
G
G
A
C
T
A
T
G
C
T
G
A
C
T
C
G
T
T
A
G
T
A
C
T
T
G
A
C
A
T
G
G
C
T
A
A
G
A
A
C
C
T
T
G
T
C
C
T
0.052838
0.02544
0.039139
0.039139
0.048924
0.033268
0.003914
0.037182
0.050881
0.021526
0.043053
0.037182
0.027397
0.04501
0.033268
0.033268
0.041096
0.033268
0.019569
0.001957
0.007828
0.001957
0.035225
0.037182
0.037182
0.039139
0.017613
0.017613
0.029354
0.02544
0.031311
0.052838
0
30,545
T
C
T
T
T
T
T
G
T
A
T
A
G
G
C
C
C
C
A
T
G
G
A
G
T
G
A
T
C
T
T
C
T
A
T
G
G
T
T
C
T
T
A
C
C
A
G
T
T
T
T
G
A
A
A
A
T
C
A
T
G
C
T
G
C
C
0.07045
0.017613
0.037182
0.039139
0.041096
0.029354
0
0.02544
0.04501
0.02544
0.043053
0.046967
0.035225
0.052838
0.02544
0.037182
0.041096
0.048924
0.033268
0.001957
0.001957
0
0.023483
0.037182
0.043053
0.017613
0.029354
0.015656
0.048924
0.023483
0.02544
0.037182
0
30,546
G
G
T
T
C
T
T
T
T
G
T
G
C
T
G
G
G
T
T
C
C
T
T
A
C
T
G
C
C
T
C
T
C
T
C
G
T
G
A
G
T
T
T
T
A
G
G
G
A
T
G
C
A
T
T
C
T
G
C
A
G
T
T
T
C
T
0.07045
0.033268
0.04501
0.033268
0.023483
0.039139
0.001957
0.031311
0.043053
0.019569
0.056751
0.035225
0.017613
0.021526
0.043053
0.027397
0.041096
0.052838
0.062622
0.001957
0.003914
0
0.019569
0.043053
0.041096
0.019569
0.029354
0.02544
0.046967
0.015656
0.027397
0.027397
0
30,547
T
G
A
C
T
G
A
C
T
T
C
A
T
T
C
T
T
G
C
A
G
G
C
T
T
C
A
G
G
G
T
A
C
G
C
C
C
A
G
A
G
C
T
C
C
A
C
A
T
T
C
T
C
C
T
C
T
T
C
C
T
G
C
T
A
T
0.068493
0.031311
0.041096
0.064579
0.041096
0.021526
0.001957
0.019569
0.046967
0.029354
0.039139
0.041096
0.039139
0.043053
0.054795
0.017613
0.037182
0.033268
0.019569
0.001957
0.001957
0.001957
0.02544
0.031311
0.041096
0.015656
0.027397
0.02544
0.027397
0.019569
0.039139
0.050881
0
30,548
T
T
T
C
A
G
A
C
C
A
G
A
A
G
T
T
G
A
T
C
A
T
A
G
C
C
T
T
G
G
G
T
T
C
A
A
T
A
A
C
A
G
A
T
G
A
A
T
A
G
A
A
A
A
G
A
T
C
A
A
T
G
A
A
G
G
0.046967
0.031311
0.031311
0.041096
0.043053
0.023483
0.005871
0.023483
0.050881
0.035225
0.041096
0.02544
0.031311
0.050881
0.043053
0.02544
0.052838
0.041096
0.023483
0.005871
0.001957
0.005871
0.027397
0.039139
0.04501
0.02544
0.031311
0.033268
0.031311
0.013699
0.015656
0.056751
0
30,549
A
G
A
G
A
T
C
A
G
A
A
C
A
A
G
A
C
A
G
T
C
T
C
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G
A
A
G
T
G
G
G
C
G
A
G
A
A
T
C
A
C
A
G
T
A
A
A
A
G
T
G
G
T
C
A
A
C
A
G
C
C
C
G
A
T
0.048924
0.017613
0.039139
0.031311
0.054795
0.015656
0.003914
0.037182
0.062622
0.031311
0.029354
0.050881
0.031311
0.043053
0.02544
0.039139
0.052838
0.035225
0.015656
0.005871
0.003914
0.009785
0.023483
0.046967
0.031311
0.027397
0.027397
0.029354
0.02544
0.027397
0.031311
0.04501
0
30,550
A
A
G
A
A
T
A
A
A
G
T
T
T
G
C
T
A
C
T
G
T
T
G
T
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T
G
G
T
T
T
C
T
C
A
T
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T
T
G
A
T
T
T
C
T
A
T
T
T
T
T
A
A
A
A
A
T
A
A
G
A
A
G
C
0.103718
0.035225
0.039139
0.062622
0.048924
0.02544
0
0.027397
0.054795
0.013699
0.023483
0.035225
0.029354
0.056751
0.043053
0.02544
0.02544
0.029354
0.015656
0.003914
0.005871
0.001957
0.02544
0.029354
0.050881
0.015656
0.029354
0.007828
0.023483
0.02544
0.043053
0.043053
0
30,551
A
T
T
T
G
C
A
T
C
T
C
A
A
G
A
C
A
C
C
C
A
T
G
T
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T
T
T
C
T
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C
C
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C
C
G
A
A
A
T
T
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C
T
C
A
T
T
T
T
T
A
G
A
A
G
T
C
T
C
A
T
T
C
T
0.088063
0.029354
0.039139
0.052838
0.043053
0.027397
0.001957
0.02544
0.064579
0.027397
0.019569
0.02544
0.031311
0.054795
0.039139
0.029354
0.043053
0.037182
0.019569
0.001957
0.003914
0.003914
0.02544
0.029354
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0.017613
0.043053
0.011742
0.019569
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0
30,552
C
T
G
T
T
G
C
C
A
T
A
C
T
A
A
C
A
A
G
A
A
A
T
T
T
G
G
G
A
A
T
G
T
A
G
A
C
A
G
T
T
G
T
G
A
A
T
G
A
G
A
C
T
T
C
T
A
A
A
A
A
T
G
A
G
C
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0
30,553
G
T
G
T
G
C
A
G
A
C
T
C
T
T
C
G
A
T
T
C
A
T
G
A
T
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C
T
C
A
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C
A
A
T
G
C
A
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A
G
G
C
T
T
G
C
A
G
A
T
G
G
C
C
A
C
A
T
A
G
C
G
G
T
0.066536
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0.023483
0.023483
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0
30,554
T
A
T
T
C
C
C
A
G
C
A
C
T
C
A
T
G
T
T
G
C
T
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A
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C
T
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C
A
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T
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C
T
A
A
T
A
T
T
A
T
T
G
A
C
C
A
T
T
T
T
G
0.064579
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0.052838
0.021526
0.039139
0.017613
0.02544
0.021526
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0.039139
0
30,555
C
A
T
A
A
A
A
A
T
G
C
A
G
C
T
G
C
C
A
T
A
A
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A
G
A
T
G
G
A
G
A
C
A
A
C
A
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C
C
A
T
G
T
G
G
G
A
A
G
A
A
C
A
T
G
T
G
G
A
A
A
A
G
G
T
0.072407
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0
0
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0.046967
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0.035225
0.017613
0.02544
0.027397
0.046967
0.04501
0
30,556
C
T
T
C
C
T
C
C
G
G
A
A
C
T
T
C
T
C
T
T
T
C
T
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A
G
A
A
A
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C
T
C
A
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T
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C
A
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G
T
A
T
G
C
A
T
C
C
C
C
A
G
A
T
T
T
C
T
G
G
T
0.068493
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0.037182
0.041096
0
30,557
C
C
T
T
T
G
C
T
G
G
G
C
A
G
A
G
G
G
A
A
T
C
T
T
C
A
G
A
A
T
T
G
T
T
T
T
A
A
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G
A
T
G
A
G
T
G
T
G
T
A
G
G
A
G
A
G
A
A
C
C
A
C
C
A
C
0.088063
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0
0
0.019569
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0.019569
0.035225
0.035225
0
30,558
A
C
T
T
A
T
G
G
C
T
G
T
A
T
T
T
G
C
A
C
T
C
A
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A
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C
A
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C
C
T
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T
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T
T
C
T
G
T
C
C
T
A
C
T
T
G
T
A
C
A
T
A
G
C
0.037182
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0
0.02544
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0
0.005871
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0.031311
0.054795
0
30,559
A
T
C
A
T
G
T
G
A
G
A
A
G
A
G
C
A
G
G
T
G
G
A
A
A
A
G
G
C
T
T
T
C
T
T
C
T
T
T
T
G
C
T
G
A
G
C
T
G
A
A
G
G
G
A
A
T
T
T
C
A
G
A
A
T
G
0.076321
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0.021526
0.009785
0.023483
0.027397
0.052838
0.062622
0
30,560
T
A
T
C
A
T
T
G
A
T
C
A
T
T
T
C
A
T
T
T
G
T
G
A
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A
T
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C
T
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T
C
C
T
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C
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T
T
T
C
T
T
G
C
T
C
A
G
A
C
A
C
A
C
A
T
T
C
0.076321
0.035225
0.052838
0.048924
0.054795
0.013699
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0
0.003914
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0.048924
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0.007828
0.02544
0.027397
0.039139
0.058708
0
30,561
T
G
T
T
T
T
C
A
G
G
T
G
G
G
G
A
T
C
C
A
A
C
A
T
G
G
T
G
A
G
G
G
C
G
A
T
A
A
T
G
G
T
C
A
G
T
T
T
C
C
C
T
G
T
T
A
C
A
C
T
C
A
A
C
A
T
0.09589
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0.052838
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0.021526
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0.021526
0.043053
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0.074364
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0.021526
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0.019569
0
0.003914
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0.017613
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0.048924
0.015656
0.039139
0.007828
0.021526
0.02544
0.035225
0.050881
0
30,562
A
T
A
T
A
C
T
C
T
T
A
G
G
A
A
T
G
A
G
C
A
A
G
T
T
A
A
A
C
A
A
G
C
C
T
T
T
C
A
T
G
A
C
T
C
A
C
T
C
A
A
A
A
A
A
A
T
T
G
C
A
T
T
T
C
G
0.099804
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0
0.001957
0
0.02544
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0.011742
0.02544
0.011742
0.011742
0.023483
0.074364
0.052838
0
30,563
A
G
A
G
G
G
A
T
T
A
A
T
G
T
A
C
A
T
A
A
A
C
A
T
G
C
A
G
C
T
T
C
C
G
T
A
A
G
A
G
A
G
G
G
A
G
A
T
G
A
C
A
A
T
C
A
T
G
T
G
G
G
A
A
G
T
0.046967
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0.056751
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0.02544
0.029354
0.009785
0.033268
0.019569
0.033268
0.046967
0
30,564
C
G
T
G
C
C
C
A
G
G
A
C
C
C
T
G
G
C
C
A
A
T
C
T
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G
G
C
T
C
C
C
C
G
C
A
T
C
C
C
C
A
G
G
C
C
A
T
C
T
C
T
T
T
C
C
A
G
G
G
C
T
G
T
G
T
0.009785
0.009785
0.023483
0.011742
0.023483
0.043053
0.013699
0.017613
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0.064579
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0.046967
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0.07045
0.068493
0.013699
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0.017613
0.046967
0.07045
0.037182
0.02544
0.001957
0.035225
0
30,565
G
A
T
C
A
T
A
A
T
G
A
A
G
A
C
T
A
T
G
G
T
G
G
C
T
G
T
C
A
T
C
A
C
G
G
A
G
A
T
C
T
C
G
C
T
C
C
T
G
T
G
C
T
T
C
C
C
A
G
C
A
C
T
T
G
T
0.007828
0.005871
0.027397
0.007828
0.029354
0.039139
0.013699
0.013699
0.056751
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0.011742
0.043053
0.056751
0.013699
0.048924
0.054795
0.062622
0.033268
0.027397
0.009785
0.019569
0.017613
0.058708
0.021526
0.021526
0.043053
0.062622
0.039139
0.019569
0.005871
0.039139
0
30,566
C
C
G
T
G
T
C
G
C
T
G
A
C
C
C
G
G
G
T
A
C
A
G
A
A
G
C
G
G
G
C
G
C
G
G
A
C
C
A
G
C
T
G
C
A
G
A
T
T
G
C
T
C
T
G
G
C
A
G
A
T
C
T
T
G
T
0.009785
0.015656
0.035225
0.017613
0.021526
0.037182
0.003914
0.019569
0.058708
0.031311
0.062622
0.011742
0.037182
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0.027397
0.029354
0.064579
0.048924
0.072407
0.013699
0.003914
0.009785
0.011742
0.060665
0.029354
0.029354
0.043053
0.041096
0.048924
0.007828
0.011742
0.04501
0
30,567
C
C
T
G
T
T
C
A
C
C
T
T
T
G
C
C
T
T
T
G
T
C
C
A
G
G
G
A
G
A
G
T
C
C
T
G
G
C
C
C
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T
G
C
C
G
A
C
A
T
C
C
C
A
G
A
G
C
T
G
G
G
C
A
G
T
0.017613
0.011742
0.031311
0.019569
0.019569
0.027397
0.007828
0.031311
0.04501
0.035225
0.054795
0.017613
0.021526
0.043053
0.009785
0.033268
0.062622
0.056751
0.084149
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0.013699
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0.048924
0.033268
0.031311
0.041096
0.050881
0.04501
0.011742
0.019569
0.031311
0
30,568
C
A
G
T
C
C
A
G
G
T
A
T
A
G
C
G
A
A
G
G
T
G
G
G
T
A
G
A
G
A
G
C
C
G
A
G
A
C
C
T
T
G
C
A
C
A
A
T
G
C
A
G
C
C
C
A
G
T
T
A
G
A
C
T
G
T
0.056751
0.011742
0.033268
0.033268
0.031311
0.021526
0
0.035225
0.074364
0.037182
0.041096
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0.029354
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0.031311
0.068493
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0.015656
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0.04501
0.023483
0.035225
0.019569
0.052838
0.021526
0.011742
0.035225
0
30,569
A
T
C
T
C
C
G
C
G
T
G
G
C
C
G
T
G
G
G
C
T
C
C
G
G
C
T
C
C
T
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C
T
C
C
G
G
C
T
C
C
T
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C
A
C
A
T
T
G
A
C
A
C
T
T
T
C
T
C
C
T
G
G
A
A
0.060665
0.021526
0.029354
0.033268
0.033268
0.019569
0.011742
0.021526
0.058708
0.027397
0.052838
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0.021526
0.035225
0.019569
0.029354
0.046967
0.029354
0.043053
0.027397
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0.011742
0.019569
0.064579
0.043053
0.021526
0.031311
0.039139
0.050881
0.013699
0.021526
0.037182
0
30,570
A
G
T
C
T
C
C
T
G
G
A
C
A
G
T
G
T
T
A
A
G
A
T
C
A
A
T
C
T
C
T
A
T
T
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T
G
T
G
A
T
T
C
T
G
C
A
G
C
C
C
A
C
C
A
A
C
G
A
G
T
A
G
A
G
G
0.021526
0.017613
0.04501
0.023483
0.035225
0.033268
0.007828
0.027397
0.054795
0.033268
0.054795
0.027397
0.02544
0.033268
0.031311
0.035225
0.056751
0.048924
0.050881
0.003914
0.005871
0.005871
0.019569
0.048924
0.035225
0.027397
0.031311
0.039139
0.035225
0.023483
0.019569
0.041096
0
30,571
C
A
A
A
T
T
G
A
A
C
C
A
G
A
G
A
A
C
T
G
A
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C
A
T
G
T
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G
G
A
A
A
T
A
A
T
C
A
C
C
A
C
0.02544
0.033268
0.043053
0.017613
0.027397
0.039139
0.003914
0.021526
0.048924
0.050881
0.064579
0.017613
0.009785
0.013699
0.039139
0.033268
0.062622
0.046967
0.064579
0.007828
0.005871
0.005871
0.017613
0.064579
0.04501
0.015656
0.033268
0.039139
0.041096
0.009785
0.009785
0.041096
0
30,572
A
G
T
A
A
G
T
T
C
A
G
C
T
C
C
C
T
A
C
T
G
G
G
G
G
T
G
G
G
C
C
A
T
A
A
T
C
A
A
G
A
G
C
T
A
T
G
A
C
T
T
A
G
A
T
C
C
T
G
G
G
G
C
T
G
C
0.037182
0.035225
0.04501
0.027397
0.031311
0.033268
0.009785
0.043053
0.050881
0.031311
0.031311
0.031311
0.043053
0.031311
0.029354
0.02544
0.054795
0.04501
0.041096
0.005871
0.007828
0.003914
0.027397
0.031311
0.035225
0.023483
0.013699
0.02544
0.023483
0.033268
0.041096
0.050881
0
30,573
C
T
T
C
C
A
C
G
T
C
C
T
T
A
T
T
G
G
C
G
A
G
G
T
A
C
A
G
C
T
C
C
C
G
A
A
G
A
T
G
A
G
C
C
T
C
T
T
C
T
T
C
G
G
G
G
C
T
C
C
A
T
G
T
A
T
0.035225
0.017613
0.066536
0.007828
0.027397
0.029354
0.011742
0.027397
0.054795
0.031311
0.074364
0.011742
0.02544
0.02544
0.023483
0.033268
0.054795
0.052838
0.029354
0.003914
0.011742
0.007828
0.013699
0.050881
0.052838
0.023483
0.02544
0.048924
0.052838
0.021526
0.015656
0.031311
0
30,574
G
C
T
G
C
T
C
T
C
C
C
T
C
A
C
A
G
C
C
T
C
A
T
C
T
G
G
A
G
A
T
A
T
G
T
C
C
A
T
C
T
C
A
T
T
C
A
C
T
G
T
T
G
C
C
A
G
C
A
G
C
T
C
C
T
A
0.058708
0.017613
0.035225
0.033268
0.019569
0.013699
0.005871
0.02544
0.046967
0.043053
0.043053
0.015656
0.043053
0.04501
0.023483
0.02544
0.058708
0.054795
0.043053
0.009785
0.011742
0.003914
0.019569
0.046967
0.058708
0.017613
0.02544
0.037182
0.056751
0.003914
0.003914
0.052838
0
30,575
A
C
T
G
C
T
T
C
A
A
G
A
T
T
A
C
C
A
G
G
A
C
T
C
C
T
A
C
A
C
A
C
T
C
T
C
T
G
A
A
A
C
T
C
A
G
G
C
T
G
A
G
G
C
A
G
C
A
G
C
T
G
A
G
G
C
0.041096
0.015656
0.035225
0.023483
0.031311
0.037182
0.003914
0.033268
0.035225
0.048924
0.050881
0.029354
0.019569
0.043053
0.033268
0.04501
0.056751
0.058708
0.031311
0
0.003914
0
0.021526
0.054795
0.027397
0.023483
0.043053
0.029354
0.043053
0.021526
0.013699
0.04501
0