Datasets:
TabBioMed
/
vep_pathogenic_coding

Dataset card Data Studio Files
xet
 Community
row_idx
int64
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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T
T
C
T
0.074364
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0.035225
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0.033268
0.017613
0.023483
0.041096
0
30,693
A
T
A
T
G
G
C
G
G
C
G
C
A
G
G
G
C
T
C
C
C
C
C
T
C
G
A
G
C
T
C
T
C
C
G
T
C
A
G
A
C
G
A
C
T
C
T
A
C
C
A
C
C
T
C
G
G
G
G
T
C
T
C
T
G
T
0.029354
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0.060665
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0.007828
0.019569
0
30,694
G
A
G
C
T
C
T
C
C
A
G
G
G
C
A
T
C
T
C
T
T
C
A
A
G
T
G
A
T
A
G
A
C
G
A
T
G
G
A
A
C
C
T
C
T
T
T
C
T
T
T
T
A
A
C
A
T
A
A
C
T
T
A
A
T
T
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0
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0
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0
30,695
A
C
T
T
C
T
T
A
A
A
C
A
G
G
C
A
G
T
G
G
A
T
C
T
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G
A
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A
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A
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T
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C
C
A
A
G
A
T
G
G
T
T
T
C
C
T
C
T
G
C
A
T
0.107632
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0
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0.068493
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0
30,696
A
C
A
G
A
T
C
T
T
T
C
A
A
T
C
A
T
T
T
G
A
C
T
C
A
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G
A
A
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C
T
T
C
T
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C
C
A
G
T
A
A
A
G
A
A
A
A
T
A
T
A
C
A
G
G
T
A
A
G
G
A
C
0.131115
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0
0.04501
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0
0
0
0.027397
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0.041096
0.074364
0.043053
0
30,697
G
A
G
A
A
A
T
A
A
G
C
A
A
A
A
A
A
T
A
A
A
A
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A
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A
C
C
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C
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A
A
G
T
T
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G
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G
G
T
T
T
G
G
T
T
T
G
C
T
C
T
T
G
T
T
G
G
T
0.099804
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0.043053
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0
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0.013699
0.02544
0.035225
0.066536
0.015656
0
30,698
G
G
A
G
C
A
C
T
G
A
G
A
C
A
G
G
G
T
C
T
T
C
T
G
T
T
C
C
A
C
C
T
C
G
G
A
C
A
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A
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G
T
T
T
A
G
C
C
T
G
T
C
C
T
C
A
G
C
T
T
T
0.080235
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0.035225
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0.033268
0.019569
0.041096
0.027397
0.035225
0.031311
0
30,699
G
A
A
A
G
A
T
A
A
C
C
A
T
C
A
T
T
T
T
A
A
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A
T
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G
T
T
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A
G
G
T
C
A
C
T
G
A
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A
A
G
A
T
G
A
C
A
G
T
G
A
G
T
T
T
T
T
A
G
C
0.113503
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0.009785
0.019569
0.021526
0.076321
0.039139
0
30,700
G
G
G
C
A
T
T
T
A
G
G
G
A
A
A
T
A
G
G
A
T
C
T
A
A
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C
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C
A
C
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T
C
A
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T
T
T
T
C
A
G
T
G
A
C
C
T
A
A
A
C
A
A
T
A
T
0.113503
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0.097847
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0
0.017613
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0.017613
0.017613
0.082192
0.041096
0
30,701
T
T
G
T
A
G
C
T
A
A
G
G
C
T
A
T
G
C
A
G
G
C
A
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A
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T
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T
C
A
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C
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G
C
A
C
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A
T
T
C
T
T
A
G
C
T
C
A
G
A
T
C
C
T
A
G
T
G
0.037182
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0
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0.064579
0.027397
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0.027397
0.041096
0
30,702
A
G
T
C
A
C
T
G
T
C
T
T
C
A
G
A
A
C
T
T
T
G
G
C
T
C
T
G
T
C
A
C
C
T
T
C
T
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A
G
C
T
T
A
G
A
A
A
T
C
T
A
T
C
T
G
T
A
T
G
T
T
T
G
T
T
0.09589
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0.058708
0.023483
0.019569
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0.013699
0.02544
0.062622
0.039139
0
30,703
T
G
T
G
A
G
G
C
A
G
G
G
G
C
T
G
G
T
G
C
G
A
A
C
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A
T
G
C
C
C
A
T
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G
T
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C
C
A
T
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C
G
G
G
C
A
C
G
G
T
T
G
T
G
C
A
C
G
T
C
A
A
C
0.04501
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0.015656
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0.019569
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0.027397
0.023483
0.054795
0.037182
0.031311
0.023483
0.023483
0.027397
0
30,704
C
A
C
A
C
T
G
T
A
T
C
T
T
T
T
A
C
T
T
A
C
G
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T
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A
T
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C
T
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A
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C
T
A
T
C
A
T
A
G
A
G
A
A
T
C
C
C
A
A
T
T
C
T
T
C
A
G
T
0.074364
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0.046967
0.076321
0.031311
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0.054795
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0.052838
0.013699
0.035225
0.02544
0.019569
0.011742
0.056751
0.050881
0
30,705
C
T
T
T
T
G
T
G
T
T
A
T
T
T
C
A
G
G
A
A
A
T
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A
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C
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C
A
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A
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T
A
C
A
G
G
G
G
C
A
C
A
G
C
A
G
A
A
A
G
T
G
T
0.107632
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0.09589
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0.019569
0
0.031311
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0
0
0
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0.013699
0.031311
0.011742
0.013699
0.02544
0.060665
0.052838
0
30,706
C
A
T
G
C
T
G
T
C
A
A
G
T
G
A
A
A
T
G
G
T
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C
C
A
A
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A
C
A
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A
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G
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T
C
T
T
T
T
C
A
T
A
T
T
C
T
T
A
T
A
A
G
A
0.093933
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0.052838
0.066536
0.041096
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0.013699
0.035225
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0
0
0.033268
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0.009785
0.009785
0.019569
0.037182
0.080235
0.033268
0
30,707
A
A
G
T
A
T
A
T
T
C
G
A
A
T
C
T
T
C
T
C
T
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T
A
G
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A
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A
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A
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C
T
G
T
A
T
A
A
A
A
T
G
A
A
T
C
C
T
T
T
T
C
0.109589
0.029354
0.066536
0.048924
0.035225
0.011742
0
0.048924
0.048924
0.021526
0.023483
0.04501
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0.033268
0.033268
0.019569
0.033268
0.023483
0.013699
0
0.003914
0
0.027397
0.015656
0.043053
0.017613
0.011742
0.009785
0.02544
0.029354
0.066536
0.050881
0
30,708
A
T
A
C
T
T
T
G
T
G
A
T
T
C
A
T
T
A
G
A
A
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T
T
G
G
C
A
A
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A
T
G
A
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C
C
C
T
T
T
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A
G
A
C
A
A
G
A
G
A
T
G
T
C
A
T
T
G
C
T
A
C
0.09002
0.029354
0.058708
0.058708
0.037182
0.021526
0.005871
0.029354
0.062622
0.023483
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0.019569
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0
0.005871
0
0.037182
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0.054795
0.023483
0.027397
0.011742
0.017613
0.02544
0.048924
0.046967
0
30,709
T
C
T
T
C
A
G
A
A
A
T
C
A
C
A
G
T
T
T
T
T
C
A
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G
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C
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C
C
A
A
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T
T
C
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C
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A
A
A
A
C
T
G
C
C
C
A
A
G
G
T
T
T
G
T
T
T
0.135029
0.043053
0.048924
0.066536
0.023483
0.021526
0.001957
0.050881
0.041096
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0
0
0.001957
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0.04501
0.013699
0.02544
0.013699
0.017613
0.02544
0.068493
0.041096
0
30,710
C
T
T
G
C
G
G
G
T
G
A
A
G
G
A
T
C
G
G
T
G
G
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C
A
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C
C
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C
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C
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G
G
A
G
A
C
G
A
A
G
A
G
A
G
G
C
A
G
A
T
G
0.039139
0.02544
0.039139
0.037182
0.048924
0.033268
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0.02544
0.046967
0.033268
0.031311
0.02544
0.027397
0.037182
0
30,711
A
C
A
C
T
A
G
T
A
G
T
A
A
A
T
G
G
C
A
T
T
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C
T
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T
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T
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T
C
A
T
T
G
T
A
G
G
T
G
C
T
G
T
T
A
C
A
A
0.107632
0.035225
0.035225
0.084149
0.050881
0.019569
0.003914
0.027397
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0.041096
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0.033268
0.017613
0.015656
0.031311
0.048924
0.037182
0
30,712
C
A
C
G
G
A
T
G
C
A
A
A
T
C
C
A
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C
C
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A
G
A
T
A
A
C
T
G
C
T
T
T
A
A
T
0.068493
0.02544
0.054795
0.058708
0.041096
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0.023483
0.023483
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0
0.001957
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0.041096
0.011742
0.031311
0.013699
0.031311
0.027397
0.058708
0.035225
0
30,713
G
T
T
C
A
G
G
A
G
A
G
T
G
A
C
C
G
T
C
T
A
A
A
G
G
T
G
G
T
T
C
A
C
A
A
G
G
G
A
A
G
G
T
A
A
G
C
G
A
G
C
C
A
G
G
T
G
A
C
C
C
G
C
A
A
G
0.07045
0.019569
0.037182
0.046967
0.043053
0.039139
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0.031311
0.052838
0.017613
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0.035225
0.04501
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0.005871
0.037182
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0.048924
0.023483
0.011742
0.019569
0.031311
0.035225
0.013699
0.052838
0
30,714
T
C
G
C
T
T
A
G
G
A
A
C
T
T
A
T
C
C
T
G
A
C
T
G
G
T
T
T
T
T
T
T
T
C
T
G
C
T
C
T
T
T
T
A
T
T
G
G
G
A
T
G
T
T
T
G
T
G
T
T
T
T
A
T
T
C
0.101761
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0.046967
0.088063
0.041096
0.005871
0.001957
0.037182
0.031311
0.023483
0.015656
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0.054795
0.043053
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0.021526
0.007828
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0.009785
0.007828
0.011742
0.02544
0.039139
0.011742
0.031311
0.011742
0.023483
0.033268
0.086106
0.037182
0
30,715
T
G
T
G
T
T
T
G
C
T
T
T
C
C
T
C
A
G
G
T
T
G
G
A
A
T
G
C
A
C
T
G
T
T
G
C
A
C
A
C
A
T
C
C
G
A
T
T
T
C
A
A
T
T
T
A
C
A
A
A
A
C
T
G
G
G
0.101761
0.039139
0.039139
0.076321
0.056751
0.017613
0.003914
0.031311
0.031311
0.009785
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0.041096
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0.02544
0.001957
0.033268
0.037182
0.078278
0.02544
0
30,716
G
A
C
G
G
G
A
T
T
T
C
C
G
G
A
C
G
C
G
C
C
C
A
G
G
A
G
T
C
T
G
C
T
T
T
G
G
A
T
G
T
C
G
T
C
G
G
G
G
T
G
T
G
C
C
T
G
A
G
C
G
C
C
T
G
G
0.02544
0.021526
0.023483
0.011742
0.02544
0.033268
0.017613
0.009785
0.033268
0.039139
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0.005871
0.017613
0.027397
0.02544
0.027397
0.054795
0.04501
0.056751
0.056751
0.015656
0.050881
0
0.060665
0.023483
0.029354
0.048924
0.060665
0.064579
0.005871
0.007828
0.017613
0
30,717
A
C
T
G
G
T
A
T
G
G
A
T
T
C
C
T
T
C
C
A
G
T
C
T
T
C
T
G
A
T
G
C
T
T
C
T
A
T
A
G
G
A
A
A
G
C
A
T
T
T
A
G
C
A
A
T
G
A
G
A
T
A
A
T
C
C
0.043053
0.027397
0.04501
0.041096
0.039139
0.02544
0.003914
0.035225
0.037182
0.033268
0.041096
0.023483
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0.035225
0.041096
0.050881
0.046967
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0.011742
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0.017613
0.033268
0.04501
0.023483
0.041096
0.023483
0.043053
0.013699
0.035225
0.037182
0
30,718
G
G
C
A
G
T
G
C
C
T
C
T
G
T
G
A
A
A
C
G
G
G
G
T
G
G
A
C
A
G
G
C
C
C
C
T
C
G
T
G
T
G
A
C
A
C
T
C
A
G
G
C
A
G
G
T
C
A
G
T
C
A
T
G
G
A
0.048924
0.02544
0.019569
0.02544
0.043053
0.027397
0.007828
0.041096
0.02544
0.033268
0.039139
0.021526
0.031311
0.054795
0.027397
0.041096
0.068493
0.037182
0.041096
0.013699
0.003914
0.001957
0.019569
0.033268
0.021526
0.041096
0.041096
0.033268
0.029354
0.011742
0.021526
0.068493
0
30,719
A
C
C
T
T
G
T
C
A
A
T
G
G
C
A
C
C
A
C
C
C
T
G
C
A
A
A
C
G
A
G
G
C
T
G
G
G
A
A
G
C
A
A
G
C
T
G
C
T
C
A
T
C
A
C
T
G
C
C
A
G
C
C
A
G
G
0.052838
0.027397
0.04501
0.031311
0.037182
0.031311
0.007828
0.019569
0.043053
0.039139
0.04501
0.021526
0.017613
0.046967
0.04501
0.02544
0.046967
0.046967
0.043053
0.009785
0.009785
0.003914
0.023483
0.027397
0.037182
0.027397
0.052838
0.041096
0.029354
0.015656
0.021526
0.027397
0
30,720
T
T
T
T
G
C
A
G
A
C
A
A
T
A
C
C
T
G
A
A
A
T
T
C
C
A
C
C
A
A
A
G
C
G
T
G
G
A
G
A
A
C
T
C
A
A
A
A
C
G
G
A
G
C
T
T
T
T
G
G
G
A
C
T
G
T
0.091977
0.046967
0.058708
0.056751
0.033268
0.019569
0.013699
0.041096
0.04501
0.02544
0.031311
0.046967
0.019569
0.02544
0.050881
0.015656
0.027397
0.015656
0.009785
0.005871
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0.02544
0.029354
0.039139
0.021526
0.031311
0.007828
0.02544
0.023483
0.072407
0.039139
0
30,721
C
A
G
A
G
T
C
C
A
A
A
C
A
G
A
A
A
T
G
A
C
T
G
C
T
C
C
C
A
A
C
A
T
T
G
T
G
C
T
C
C
A
A
A
C
C
A
C
T
A
T
T
C
A
C
A
C
C
T
A
T
A
G
C
A
C
0.072407
0.029354
0.029354
0.074364
0.041096
0.027397
0
0.039139
0.043053
0.027397
0.037182
0.027397
0.013699
0.033268
0.039139
0.037182
0.046967
0.031311
0.011742
0.001957
0
0.001957
0.029354
0.041096
0.046967
0.023483
0.033268
0.013699
0.031311
0.017613
0.046967
0.050881
0
30,722
G
C
T
G
T
G
T
A
C
T
T
A
C
C
T
G
G
A
G
A
G
A
T
C
T
T
T
G
C
T
G
C
C
G
G
G
C
G
T
G
G
T
C
C
T
T
T
C
C
A
C
C
A
T
G
T
T
G
G
T
A
A
A
T
C
T
0.072407
0.019569
0.029354
0.054795
0.037182
0.029354
0.009785
0.031311
0.027397
0.043053
0.031311
0.054795
0.021526
0.041096
0.035225
0.031311
0.039139
0.039139
0.019569
0.005871
0.011742
0.003914
0.027397
0.037182
0.037182
0.021526
0.023483
0.019569
0.029354
0.035225
0.031311
0.048924
0
30,723
G
C
C
A
C
T
G
A
A
A
G
C
T
G
A
T
T
C
T
C
C
T
C
T
T
A
A
C
T
C
C
A
C
G
C
T
C
T
C
A
A
C
T
G
C
C
A
G
A
A
A
A
G
A
A
A
A
A
C
A
A
A
G
T
T
T
0.088063
0.031311
0.048924
0.041096
0.029354
0.017613
0.005871
0.050881
0.046967
0.043053
0.02544
0.015656
0.021526
0.031311
0.031311
0.035225
0.050881
0.039139
0.013699
0.003914
0.001957
0.003914
0.02544
0.041096
0.039139
0.015656
0.039139
0.023483
0.027397
0.021526
0.050881
0.039139
0
30,724
C
C
A
A
C
T
C
A
A
T
G
A
A
T
T
C
C
A
T
G
T
C
T
G
C
T
C
A
C
C
T
G
C
G
T
C
A
T
T
C
T
T
G
G
G
C
A
C
A
G
T
C
C
C
C
T
T
A
T
G
A
A
C
T
T
T
0.035225
0.035225
0.031311
0.039139
0.04501
0.041096
0.011742
0.031311
0.039139
0.02544
0.046967
0.037182
0.017613
0.039139
0.02544
0.048924
0.048924
0.037182
0.027397
0.005871
0.007828
0.005871
0.037182
0.027397
0.052838
0.033268
0.027397
0.015656
0.031311
0.011742
0.027397
0.052838
0
30,725
C
T
G
C
A
C
A
T
T
T
C
T
C
T
C
T
T
G
C
C
T
A
C
T
A
T
C
A
G
A
T
G
T
A
G
G
G
G
G
T
G
A
A
A
G
G
C
A
G
A
G
C
T
T
G
G
G
G
T
C
A
G
C
G
G
C
0.050881
0.029354
0.043053
0.011742
0.041096
0.029354
0.007828
0.041096
0.043053
0.046967
0.041096
0.005871
0.011742
0.017613
0.037182
0.048924
0.062622
0.046967
0.04501
0.015656
0
0.015656
0.019569
0.04501
0.027397
0.019569
0.050881
0.043053
0.031311
0.021526
0.019569
0.029354
0
30,726
G
T
T
T
T
T
A
A
G
T
T
A
T
A
C
A
A
A
C
G
C
G
T
A
T
G
T
G
C
C
T
A
C
G
T
G
T
A
T
G
T
A
A
A
T
T
C
A
T
A
G
G
A
A
G
A
C
A
A
A
T
C
A
G
A
T
0.082192
0.039139
0.035225
0.072407
0.062622
0.019569
0.019569
0.027397
0.037182
0.015656
0.023483
0.056751
0.02544
0.052838
0.043053
0.029354
0.019569
0.013699
0.007828
0.005871
0.005871
0.003914
0.029354
0.019569
0.039139
0.013699
0.027397
0.007828
0.015656
0.046967
0.062622
0.039139
0
30,727
T
T
G
A
T
C
A
A
G
G
T
A
G
C
T
C
T
G
T
C
C
C
T
C
A
G
G
T
G
T
T
A
C
T
C
C
A
A
G
T
T
T
T
C
T
G
A
T
G
C
C
T
C
G
A
T
T
G
A
A
T
T
T
T
T
T
0.099804
0.021526
0.037182
0.080235
0.033268
0.015656
0.001957
0.039139
0.035225
0.037182
0.027397
0.050881
0.033268
0.031311
0.043053
0.017613
0.033268
0.019569
0.013699
0
0.005871
0
0.039139
0.029354
0.029354
0.015656
0.021526
0.015656
0.015656
0.035225
0.07045
0.050881
0
30,728
G
G
A
A
A
A
T
G
A
A
A
A
T
G
A
C
A
A
G
A
T
T
G
T
T
C
C
C
A
A
A
G
C
A
A
C
A
G
C
C
A
G
T
C
T
A
C
C
T
G
A
A
G
C
A
G
A
G
G
A
G
C
T
G
A
T
0.064579
0.033268
0.054795
0.054795
0.031311
0.023483
0.005871
0.023483
0.043053
0.033268
0.048924
0.02544
0.033268
0.019569
0.046967
0.017613
0.054795
0.029354
0.031311
0.001957
0.009785
0.009785
0.011742
0.027397
0.07045
0.015656
0.019569
0.019569
0.037182
0.017613
0.027397
0.056751
0
30,729
C
C
T
G
A
G
A
A
G
C
T
T
C
T
C
C
G
T
G
A
G
G
G
C
C
T
G
C
A
G
G
G
C
G
A
G
C
C
G
C
T
C
C
G
T
G
T
C
G
G
C
C
G
C
C
T
C
C
T
T
G
A
A
A
G
T
0.015656
0.003914
0.050881
0.007828
0.017613
0.019569
0.013699
0.02544
0.048924
0.052838
0.072407
0.003914
0.019569
0.019569
0.019569
0.02544
0.060665
0.039139
0.029354
0.039139
0.015656
0.021526
0.003914
0.086106
0.039139
0.039139
0.029354
0.048924
0.080235
0.007828
0.003914
0.039139
0
30,730
A
G
G
A
G
A
G
C
T
G
G
A
T
T
T
G
C
T
G
G
A
G
G
A
G
T
C
A
C
T
T
G
C
A
A
A
G
C
T
C
T
G
C
C
T
G
G
A
G
C
A
T
T
C
A
T
A
G
T
C
A
C
T
G
A
T
0.048924
0.021526
0.043053
0.027397
0.043053
0.027397
0.005871
0.039139
0.043053
0.046967
0.031311
0.011742
0.021526
0.023483
0.035225
0.054795
0.062622
0.041096
0.035225
0.013699
0.011742
0.011742
0.019569
0.035225
0.04501
0.023483
0.056751
0.021526
0.037182
0.015656
0.011742
0.033268
0
30,731
A
G
C
T
C
G
G
G
C
C
T
G
G
G
C
C
G
G
A
G
C
C
C
G
A
G
C
C
T
G
A
C
C
C
A
G
G
G
C
C
A
C
T
G
C
A
G
C
T
C
C
G
G
G
G
C
A
C
C
C
C
G
G
A
G
G
0.001957
0.007828
0.009785
0
0.015656
0.031311
0.015656
0.011742
0.015656
0.058708
0.031311
0.003914
0.013699
0.021526
0.009785
0.039139
0.056751
0.052838
0.062622
0.101761
0.021526
0.11546
0.005871
0.04501
0.005871
0.019569
0.046967
0.121331
0.035225
0.007828
0.001957
0.011742
0
30,732
G
T
G
G
T
G
G
T
G
A
T
G
G
T
G
G
T
G
G
T
T
G
G
C
G
G
C
G
G
C
T
G
C
C
G
G
C
G
G
G
A
C
T
G
C
G
G
C
G
G
C
C
G
C
G
G
C
G
G
C
C
G
G
C
G
T
0.003914
0.017613
0.015656
0
0.009785
0.039139
0.017613
0.017613
0.027397
0.048924
0.037182
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0.013699
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0.009785
0.021526
0.04501
0.09589
0.041096
0.005871
0.005871
0.011742
0
30,733
C
C
C
C
T
G
C
T
T
G
T
G
G
T
G
C
A
G
G
G
G
G
G
T
G
C
C
A
T
T
G
C
C
G
T
G
G
T
G
C
T
T
G
G
C
A
T
T
G
A
G
G
G
G
C
T
G
C
A
G
G
T
G
A
T
T
0.027397
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0
0.007828
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0.054795
0.035225
0.052838
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0.013699
0.033268
0
30,734
C
G
T
C
C
T
C
T
G
T
A
A
G
T
C
C
T
G
G
A
G
C
A
C
A
T
C
C
T
G
G
C
C
G
G
T
C
C
C
T
T
C
A
C
C
A
T
T
T
T
T
G
T
C
A
T
A
C
A
G
G
A
G
C
T
T
0.054795
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0.031311
0.058708
0.013699
0.011742
0.033268
0
30,735
C
A
T
G
T
C
T
G
T
G
G
A
C
A
A
A
T
G
C
G
T
G
G
A
C
T
T
C
T
G
C
A
C
T
G
A
G
A
A
G
G
T
G
A
G
C
A
C
A
A
G
G
T
G
G
G
G
C
C
C
A
T
G
G
A
T
0.023483
0.023483
0.050881
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0.046967
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0.04501
0.011742
0.015656
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0
30,736
G
A
G
G
C
T
G
A
G
T
C
C
A
A
G
G
C
T
G
G
G
C
C
C
A
A
G
G
C
T
G
A
C
G
G
A
G
A
G
G
A
G
G
A
T
G
A
G
G
T
T
A
A
G
G
C
G
G
C
T
A
G
G
A
C
G
0.035225
0.019569
0.039139
0.017613
0.019569
0.021526
0.013699
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0.041096
0.04501
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0.052838
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0.054795
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0.021526
0.015656
0.056751
0.052838
0.015656
0.021526
0.027397
0
30,737
C
C
T
C
A
G
C
C
C
C
A
C
A
T
C
G
A
T
G
G
G
G
C
C
C
C
A
G
C
C
C
A
T
A
A
C
C
C
T
G
G
G
G
G
G
C
C
C
A
T
C
A
C
C
C
C
C
C
A
C
C
A
A
C
T
C
0.003914
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0.019569
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0.029354
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0.058708
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0.031311
0.029354
0.02544
0.084149
0.048924
0.013699
0.003914
0.027397
0
30,738
T
A
T
G
A
A
C
A
G
A
C
C
T
C
T
T
T
T
G
G
T
A
G
T
A
G
G
T
T
C
C
A
T
G
G
A
C
A
G
G
G
C
C
T
C
T
G
T
G
G
C
A
C
T
G
G
G
T
T
C
T
G
T
G
G
C
0.011742
0.013699
0.019569
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0.048924
0.046967
0.011742
0.033268
0.041096
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0.017613
0.080235
0.080235
0.099804
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0.013699
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0.019569
0.029354
0.056751
0.066536
0.039139
0.017613
0.007828
0.011742
0
30,739
G
T
C
C
A
C
A
G
A
A
C
C
C
A
G
T
G
C
C
A
C
A
G
A
G
G
C
C
C
T
G
T
C
C
A
T
G
G
A
A
C
C
T
A
C
T
A
C
C
A
A
A
A
G
A
G
G
T
C
T
G
T
T
C
A
T
0.011742
0.013699
0.019569
0.011742
0.048924
0.046967
0.011742
0.033268
0.041096
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0.017613
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0.029354
0.056751
0.07045
0.039139
0.017613
0.007828
0.011742
0
30,740
G
T
C
A
G
A
G
G
A
G
T
G
G
T
G
T
C
A
G
T
G
C
T
G
T
T
C
C
T
C
A
G
C
A
T
T
T
C
T
G
G
A
G
G
C
T
C
C
G
T
T
T
C
T
G
G
C
A
G
G
A
A
A
T
C
T
0.009785
0.023483
0.019569
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0.033268
0.035225
0.011742
0.031311
0.033268
0.048924
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0.009785
0.017613
0.023483
0.027397
0.04501
0.086106
0.064579
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0.003914
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0.019569
0.048924
0.023483
0.031311
0.054795
0.056751
0.054795
0.011742
0.003914
0.029354
0
30,741
G
G
T
T
G
T
G
T
T
G
A
C
T
A
G
G
T
T
T
A
T
G
T
C
C
A
A
G
G
A
G
G
T
G
G
T
A
C
T
T
G
T
A
A
A
T
G
T
C
C
A
T
C
A
T
C
A
G
G
A
A
C
T
C
A
C
0.037182
0.039139
0.033268
0.013699
0.052838
0.037182
0.009785
0.029354
0.02544
0.043053
0.052838
0.005871
0.017613
0.02544
0.033268
0.054795
0.056751
0.043053
0.043053
0.019569
0.007828
0.017613
0.015656
0.04501
0.033268
0.017613
0.041096
0.031311
0.046967
0.017613
0.019569
0.033268
0
30,742
G
C
T
G
A
A
A
A
T
T
C
C
T
G
C
T
G
C
A
T
C
G
G
C
T
C
C
T
C
G
C
G
C
G
C
A
C
A
C
A
C
C
T
G
G
T
G
T
G
G
G
G
G
C
T
C
C
C
G
G
C
C
C
A
T
T
0.046967
0.031311
0.037182
0.02544
0.043053
0.033268
0.011742
0.021526
0.043053
0.046967
0.041096
0.011742
0.023483
0.033268
0.029354
0.043053
0.056751
0.039139
0.033268
0.015656
0.007828
0.019569
0.013699
0.04501
0.039139
0.013699
0.046967
0.027397
0.037182
0.023483
0.02544
0.033268
0
30,743
A
C
T
C
A
C
A
T
A
G
C
C
C
A
C
G
G
T
C
T
T
G
G
C
C
A
G
G
C
G
G
A
T
G
G
C
A
C
A
C
T
G
T
G
A
A
G
A
A
A
C
A
G
A
A
A
G
A
G
G
C
C
A
A
G
C
0.029354
0.015656
0.039139
0.021526
0.033268
0.027397
0.001957
0.029354
0.041096
0.037182
0.052838
0.017613
0.02544
0.037182
0.029354
0.041096
0.064579
0.062622
0.046967
0.013699
0.001957
0.013699
0.023483
0.033268
0.037182
0.02544
0.039139
0.058708
0.041096
0.009785
0.011742
0.037182
0
30,744
T
G
C
C
T
C
G
T
C
T
G
G
G
T
T
T
T
C
G
C
T
G
G
T
G
A
T
T
C
T
G
G
C
G
G
C
A
A
T
G
A
C
G
T
G
G
C
C
T
C
G
G
G
C
G
A
G
G
G
G
A
G
G
G
T
T
0.066536
0.027397
0.015656
0.033268
0.031311
0.031311
0.011742
0.027397
0.041096
0.013699
0.033268
0.029354
0.043053
0.043053
0.029354
0.037182
0.04501
0.064579
0.064579
0.015656
0.009785
0.009785
0.013699
0.039139
0.023483
0.02544
0.021526
0.037182
0.04501
0.011742
0.023483
0.035225
0
30,745
C
A
G
C
A
T
G
A
A
C
T
G
G
A
A
T
T
C
T
A
C
C
A
C
G
C
A
G
G
T
G
C
C
G
T
C
C
G
G
G
A
G
C
T
G
C
C
G
G
T
G
C
T
G
C
A
G
G
C
T
G
T
T
T
A
T
0.029354
0.023483
0.017613
0.017613
0.043053
0.037182
0.019569
0.019569
0.035225
0.039139
0.058708
0.013699
0.013699
0.02544
0.013699
0.052838
0.074364
0.041096
0.048924
0.027397
0.009785
0.013699
0.015656
0.04501
0.029354
0.027397
0.056751
0.046967
0.04501
0.017613
0.015656
0.02544
0
30,746
A
A
T
T
T
T
G
G
G
A
A
T
G
C
C
C
T
C
T
G
C
C
C
G
G
G
C
C
A
T
C
T
C
G
G
A
T
G
C
C
C
G
C
A
G
G
T
A
C
A
G
A
A
G
G
T
C
C
T
C
T
C
C
A
G
T
0.076321
0.019569
0.033268
0.033268
0.035225
0.029354
0.019569
0.02544
0.033268
0.017613
0.037182
0.021526
0.031311
0.043053
0.033268
0.039139
0.039139
0.046967
0.050881
0.019569
0.009785
0.013699
0.013699
0.027397
0.029354
0.017613
0.04501
0.041096
0.033268
0.031311
0.023483
0.029354
0
30,747
T
A
A
T
C
A
C
A
G
C
C
C
T
G
T
C
C
C
T
A
T
C
A
T
C
A
C
A
C
C
C
A
C
T
G
A
C
C
C
C
A
T
T
G
A
C
A
G
A
G
A
A
A
T
T
G
A
A
T
T
C
C
T
C
C
T
0.046967
0.011742
0.046967
0.039139
0.019569
0.02544
0.003914
0.031311
0.052838
0.035225
0.050881
0.035225
0.037182
0.029354
0.037182
0.02544
0.046967
0.037182
0.041096
0.005871
0.005871
0.003914
0.029354
0.046967
0.039139
0.029354
0.033268
0.02544
0.04501
0.013699
0.019569
0.048924
0
30,748
C
A
G
G
G
G
C
A
A
C
T
T
C
T
C
C
C
G
G
T
T
G
A
A
G
T
C
C
T
T
G
A
C
G
G
C
C
T
G
G
G
C
G
G
T
T
T
T
G
T
A
G
G
C
T
G
A
G
T
C
T
G
G
G
A
T
0.019569
0.029354
0.023483
0.011742
0.035225
0.043053
0.005871
0.011742
0.04501
0.043053
0.058708
0.007828
0.037182
0.029354
0.027397
0.031311
0.080235
0.056751
0.072407
0.019569
0.003914
0.009785
0.013699
0.041096
0.02544
0.027397
0.039139
0.046967
0.04501
0.007828
0.013699
0.037182
0
30,749
A
A
G
T
G
C
T
T
C
G
A
G
A
A
G
G
T
G
G
A
G
A
A
C
A
A
G
A
T
G
A
G
C
G
G
C
T
C
C
T
C
C
C
G
C
A
A
G
G
G
C
T
G
C
C
T
G
T
G
G
G
C
T
C
T
T
0.001957
0.015656
0.035225
0.005871
0.058708
0.031311
0.009785
0.023483
0.041096
0.023483
0.060665
0.009785
0.017613
0.029354
0.023483
0.068493
0.046967
0.043053
0.050881
0.039139
0.015656
0.029354
0.009785
0.056751
0.029354
0.027397
0.041096
0.064579
0.048924
0.011742
0.003914
0.02544
0
30,750
T
T
G
C
T
A
C
C
G
A
A
G
A
T
G
C
C
T
T
T
G
A
A
T
T
T
A
G
T
A
A
A
C
A
T
C
A
A
C
T
A
G
G
T
A
T
G
A
T
T
T
C
T
T
T
T
T
C
T
G
T
C
C
C
G
T
0.074364
0.046967
0.031311
0.058708
0.029354
0.027397
0.011742
0.027397
0.046967
0.017613
0.02544
0.046967
0.041096
0.037182
0.037182
0.02544
0.033268
0.031311
0.031311
0.011742
0.011742
0.003914
0.033268
0.019569
0.066536
0.009785
0.021526
0.011742
0.029354
0.013699
0.035225
0.050881
0
30,751
C
T
T
T
A
C
T
C
C
C
A
G
T
C
C
C
A
T
T
T
A
C
A
A
A
A
A
T
A
A
C
G
T
T
T
G
T
G
T
T
T
T
A
C
C
A
G
T
T
A
T
A
G
T
T
G
T
A
G
T
A
C
C
C
A
C
0.07045
0.052838
0.041096
0.031311
0.046967
0.017613
0.009785
0.041096
0.043053
0.02544
0.031311
0.027397
0.013699
0.029354
0.054795
0.027397
0.054795
0.046967
0.039139
0.001957
0.003914
0.003914
0.013699
0.031311
0.050881
0.021526
0.035225
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G
C
A
G
G
G
C
C
C
T
G
A
C
A
T
G
G
C
A
G
G
T
G
A
T
A
T
C
C
A
G
G
C
C
A
C
T
G
T
T
G
G
G
T
G
C
C
A
T
G
G
A
G
T
T
G
G
G
G
A
G
A
G
T
T
A
0.080235
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30,753
T
C
A
G
G
T
T
G
G
A
C
T
T
C
T
T
C
T
G
A
G
A
C
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A
C
T
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C
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G
A
C
A
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A
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C
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G
C
G
T
C
T
G
G
G
T
G
A
G
C
A
A
A
C
T
C
T
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0
30,754
C
A
T
G
A
A
G
G
A
G
G
G
G
A
A
T
C
A
A
G
A
G
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A
T
A
C
A
T
G
A
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G
A
C
C
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A
T
C
G
G
C
C
G
A
G
T
C
T
G
A
G
G
G
A
C
A
0.031311
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0
30,755
T
G
C
C
T
C
C
A
G
G
A
G
C
C
C
T
G
C
C
A
C
G
G
C
A
C
A
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C
C
A
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G
G
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C
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C
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G
C
T
C
C
A
G
A
G
T
G
G
G
C
A
G
G
G
C
T
G
G
G
T
0.015656
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0.023483
0
30,756
C
C
A
G
G
T
C
C
T
C
A
C
C
G
G
T
C
C
C
T
C
C
C
A
G
C
C
C
T
G
C
C
C
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C
T
C
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G
G
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G
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A
G
C
G
T
G
C
C
C
G
G
T
G
G
G
T
G
T
G
C
C
G
T
0.015656
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0.054795
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0.007828
0.02544
0
30,757
G
A
T
A
C
A
G
G
A
G
C
C
T
G
G
C
G
G
C
G
C
C
G
A
A
G
C
A
C
C
C
G
C
G
C
A
G
G
C
C
A
A
G
A
C
G
G
C
T
C
C
C
C
A
G
G
C
C
A
A
G
A
C
G
G
T
0.019569
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0
30,758
C
C
C
A
G
G
C
C
C
G
C
T
T
G
A
T
A
C
C
A
A
T
G
T
T
G
G
G
T
A
A
G
C
T
G
A
G
G
T
C
C
A
C
T
T
T
C
C
C
A
T
T
G
C
T
G
T
G
G
G
G
T
T
G
A
T
0.048924
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0.031311
0
30,759
G
A
A
C
T
T
C
T
C
G
T
G
G
C
C
C
A
G
G
G
A
G
C
T
G
A
T
G
T
C
C
A
C
G
C
C
C
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G
G
C
C
C
G
T
G
G
G
C
G
C
T
T
C
T
T
C
C
A
G
C
C
C
A
A
T
0.007828
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0
30,760
T
A
C
G
T
G
G
A
A
C
T
T
C
T
C
G
T
G
G
C
C
C
A
G
G
G
A
G
C
T
G
A
T
G
T
C
C
A
C
G
C
C
C
A
G
G
C
C
C
G
T
G
G
G
C
G
C
T
T
C
T
T
C
C
A
C
0.007828
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0
30,761
T
T
C
A
C
T
C
T
C
C
T
C
T
T
T
C
T
C
G
C
G
A
C
G
A
G
C
C
A
A
C
T
C
T
C
T
C
A
C
C
T
C
C
T
C
A
A
G
A
T
T
T
C
G
A
A
T
A
A
G
T
T
G
C
T
T
0.027397
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0.037182
0
30,762
T
T
T
C
T
C
T
T
T
C
C
C
A
T
T
C
C
A
G
A
T
C
G
G
G
A
G
G
A
G
T
G
C
A
C
T
T
G
T
G
A
C
C
T
C
C
T
C
T
T
C
A
T
C
T
C
T
G
C
C
T
T
C
C
T
T
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0
30,763
T
C
A
T
G
T
C
T
A
T
C
A
C
A
T
T
T
G
T
C
T
T
T
G
C
C
A
G
G
A
A
C
T
T
T
C
A
G
G
A
C
C
A
G
C
T
T
C
G
A
A
T
G
G
A
G
G
G
A
T
C
A
G
C
C
C
0.054795
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0.023483
0.027397
0.039139
0
30,764
C
A
A
T
G
C
T
T
T
T
A
C
C
T
T
T
C
T
G
A
G
A
C
A
C
A
G
A
G
A
C
C
C
T
G
G
C
A
C
T
T
C
C
T
C
T
G
T
G
T
T
G
C
T
G
A
C
A
C
T
G
C
T
T
T
T
0.09002
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0.035225
0.013699
0
0.035225
0.064579
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0.035225
0.023483
0.062622
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0.021526
0
0
0
0.019569
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0.058708
0.02544
0.029354
0.023483
0.023483
0.013699
0.031311
0.058708
0
30,765
G
C
C
A
C
T
A
T
T
G
A
A
A
G
A
A
G
G
A
C
G
G
T
G
A
T
G
T
C
A
T
C
T
G
G
C
T
T
T
C
C
A
C
C
T
A
C
A
A
T
G
A
A
A
A
T
G
A
G
A
A
C
C
T
A
C
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0
0.027397
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0.029354
0.029354
0.033268
0.052838
0
30,766
C
A
C
C
T
G
C
A
A
T
T
T
T
C
C
A
T
C
C
A
G
T
T
C
T
C
C
A
C
T
C
A
C
A
G
T
C
A
G
C
C
T
C
C
T
G
C
T
C
C
G
A
T
A
T
C
T
A
C
A
A
G
T
T
G
G
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0.017613
0.043053
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0.031311
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0.048924
0.043053
0
30,767
G
C
C
A
G
C
G
G
C
C
C
A
C
A
C
C
G
C
T
G
C
C
G
C
C
C
C
C
G
G
G
A
C
C
C
C
C
G
G
A
G
A
G
G
C
T
G
C
T
G
A
G
A
C
C
C
C
C
G
C
C
C
G
G
C
G
0.001957
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0
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0
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0
30,768
A
A
G
C
A
G
C
T
T
G
C
T
C
C
A
G
C
A
T
C
C
A
G
G
A
G
G
T
C
C
G
G
T
G
G
T
G
C
A
C
A
C
G
G
C
T
T
G
A
G
A
T
G
C
C
T
G
A
C
A
A
C
C
T
T
C
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0
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0.046967
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0
30,769
T
A
C
T
C
A
C
C
G
T
A
G
A
C
T
G
A
G
G
C
A
G
T
C
C
T
T
T
G
T
T
A
C
T
G
T
T
T
C
G
A
C
C
T
C
T
G
A
A
A
A
G
A
T
T
A
A
A
T
A
T
T
A
T
T
T
0.09002
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0
0.04501
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0.017613
0.017613
0.021526
0.031311
0.080235
0.033268
0
30,770
G
T
C
T
C
G
G
C
G
G
G
C
C
T
C
C
C
C
G
C
C
C
C
T
T
C
G
T
C
G
T
C
C
T
C
C
T
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C
T
C
C
C
C
C
T
C
G
C
C
A
G
C
C
C
G
G
G
C
G
C
C
C
C
T
G
0.005871
0.013699
0.009785
0
0.009785
0.017613
0.019569
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0.009785
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0.050881
0.121331
0.04501
0.005871
0
0.005871
0
30,771
C
A
A
A
G
G
A
C
A
G
G
T
T
T
T
G
T
A
C
G
G
C
G
A
A
C
C
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C
C
T
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C
C
A
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C
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G
C
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A
T
T
T
C
C
A
G
A
A
G
G
C
T
G
A
T
T
T
C
C
0.113503
0.039139
0.046967
0.037182
0.046967
0.017613
0.009785
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0.015656
0.033268
0.041096
0.033268
0.033268
0.02544
0.015656
0.015656
0.005871
0.023483
0.033268
0.052838
0.017613
0.021526
0.021526
0.050881
0.021526
0.037182
0.023483
0
30,772
T
T
T
C
A
C
A
G
G
T
G
A
T
A
G
A
T
T
A
T
A
C
T
T
G
T
C
G
A
G
T
T
T
G
T
C
A
A
A
T
G
G
C
C
T
T
T
G
T
T
T
T
C
T
C
A
A
G
G
T
A
A
A
A
T
G
0.088063
0.039139
0.041096
0.072407
0.054795
0.015656
0.003914
0.033268
0.048924
0.023483
0.023483
0.068493
0.027397
0.027397
0.056751
0.023483
0.021526
0.023483
0.007828
0
0.005871
0.001957
0.043053
0.023483
0.04501
0.021526
0.011742
0.009785
0.021526
0.023483
0.050881
0.041096
0
30,773
T
T
G
T
G
G
A
T
C
A
T
A
T
T
A
A
A
G
G
G
C
T
T
G
A
A
A
C
A
C
A
T
C
T
A
A
T
T
G
C
A
C
T
T
A
A
A
C
T
T
G
A
A
G
A
A
C
T
T
A
T
T
T
T
A
A
0.084149
0.041096
0.056751
0.048924
0.056751
0.02544
0.001957
0.041096
0.060665
0.015656
0.017613
0.031311
0.02544
0.035225
0.048924
0.041096
0.019569
0.035225
0.017613
0.005871
0.001957
0
0.029354
0.031311
0.046967
0.017613
0.013699
0.013699
0.019569
0.02544
0.050881
0.039139
0
30,774
G
T
G
G
A
C
T
T
T
G
A
A
G
G
A
T
T
G
G
T
T
G
T
G
C
T
T
T
C
A
A
G
T
G
T
C
T
G
T
T
A
A
G
A
G
T
C
T
T
A
A
G
C
C
A
A
C
A
A
A
T
T
G
C
C
C
0.109589
0.031311
0.072407
0.058708
0.046967
0.017613
0.003914
0.029354
0.064579
0.027397
0.023483
0.023483
0.023483
0.031311
0.046967
0.02544
0.031311
0.027397
0.009785
0
0.003914
0
0.02544
0.015656
0.076321
0.011742
0.02544
0.013699
0.019569
0.029354
0.039139
0.035225
0
30,775
C
T
T
G
A
C
A
T
A
G
A
T
T
T
G
G
G
G
G
T
T
A
G
G
T
T
T
A
T
A
G
C
C
G
C
C
A
G
T
C
A
A
C
T
G
A
C
C
T
G
T
T
C
G
G
G
C
A
A
A
A
T
C
T
A
T
0.02544
0.021526
0.035225
0.015656
0.021526
0.043053
0.001957
0.035225
0.046967
0.033268
0.058708
0.009785
0.019569
0.021526
0.029354
0.037182
0.058708
0.054795
0.064579
0.013699
0.015656
0.011742
0.017613
0.062622
0.037182
0.031311
0.031311
0.037182
0.046967
0.011742
0.007828
0.041096
0