row_idx
int64
f_0_ref__32
string
f_1_ref__31
string
f_2_ref__30
string
f_3_ref__29
string
f_4_ref__28
string
f_5_ref__27
string
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string
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string
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string
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string
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string
f_11_ref__21
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
f_36_ref__4
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
f_64_ref__32
string
f_65_alt
string
f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
4,147
T
G
A
G
G
A
A
G
T
C
G
A
A
G
C
G
G
C
C
C
T
T
C
C
A
C
G
T
G
T
C
C
C
G
G
T
C
G
G
G
G
A
G
G
T
C
T
G
C
C
G
C
C
T
T
C
T
T
C
T
G
C
A
C
C
T
0.039139
0.015656
0.035225
0.011742
0.027397
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0.02544
0.046967
0.04501
0.060665
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0.005871
0.005871
0.011742
1
4,148
C
G
A
T
G
G
C
A
T
A
G
C
C
C
A
C
A
C
A
G
G
A
C
A
T
G
A
G
G
A
A
G
T
C
G
A
A
G
C
G
G
C
C
C
T
T
C
C
A
C
G
T
G
T
C
C
C
G
G
T
C
G
G
G
G
A
0.043053
0.013699
0.037182
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0.02544
0.043053
0.021526
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0.033268
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0.058708
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1
4,149
C
C
C
G
A
C
C
G
G
G
A
C
A
C
G
T
G
G
A
A
G
G
G
C
C
G
C
T
T
C
G
A
C
T
T
C
C
T
C
A
T
G
T
C
C
T
G
T
G
T
G
G
G
C
T
A
T
G
C
C
A
T
C
G
G
G
0.043053
0.013699
0.037182
0.015656
0.02544
0.043053
0.021526
0.007828
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0.023483
0.066536
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0.033268
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0.050881
0.056751
0.074364
0.033268
0.019569
0.015656
0.015656
0.029354
0.027397
0.046967
0.043053
0.058708
0.054795
0.003914
0.005871
0.015656
1
4,150
C
G
A
C
C
G
G
G
A
C
A
C
G
T
G
G
A
A
G
G
G
C
C
G
C
T
T
C
G
A
C
T
T
C
C
T
C
A
T
G
T
C
C
T
G
T
G
T
G
G
G
C
T
A
T
G
C
C
A
T
C
G
G
C
C
C
0.043053
0.013699
0.037182
0.017613
0.02544
0.043053
0.021526
0.007828
0.035225
0.023483
0.064579
0.005871
0.019569
0.023483
0.035225
0.033268
0.050881
0.056751
0.074364
0.033268
0.019569
0.015656
0.015656
0.029354
0.027397
0.046967
0.043053
0.058708
0.052838
0.003914
0.005871
0.015656
1
4,151
A
T
T
T
T
T
C
C
C
G
C
A
G
A
G
A
T
A
G
G
G
G
A
A
C
C
T
C
C
A
G
A
C
G
T
T
G
C
C
C
A
G
G
C
C
G
A
T
G
G
C
A
T
A
G
C
C
C
A
C
A
C
A
G
G
T
0.041096
0.013699
0.037182
0.02544
0.027397
0.04501
0.017613
0.005871
0.041096
0.019569
0.062622
0.009785
0.023483
0.027397
0.033268
0.029354
0.050881
0.054795
0.07045
0.031311
0.019569
0.013699
0.013699
0.027397
0.033268
0.046967
0.039139
0.054795
0.048924
0.005871
0.009785
0.019569
1
4,152
C
C
C
G
G
G
C
C
A
G
C
A
C
C
T
A
C
C
C
C
C
A
C
C
A
T
T
T
T
T
C
C
C
G
C
A
G
A
G
A
T
A
G
G
G
G
A
A
C
C
T
C
C
A
G
A
C
G
T
T
G
C
C
C
A
G
0.050881
0.013699
0.037182
0.029354
0.029354
0.041096
0.013699
0.005871
0.041096
0.019569
0.062622
0.013699
0.023483
0.029354
0.035225
0.027397
0.050881
0.054795
0.066536
0.027397
0.017613
0.011742
0.013699
0.027397
0.035225
0.041096
0.039139
0.054795
0.048924
0.007828
0.009785
0.019569
1
4,153
C
C
A
C
C
A
C
C
C
A
G
G
T
C
C
C
T
G
A
T
C
T
G
C
A
G
A
C
T
T
A
C
C
C
T
T
G
A
A
C
A
T
A
G
G
A
G
C
C
A
G
C
T
T
C
C
A
T
A
C
C
C
C
T
A
T
0.015656
0.005871
0.031311
0.005871
0.031311
0.046967
0.003914
0.021526
0.048924
0.043053
0.064579
0.019569
0.027397
0.021526
0.017613
0.046967
0.076321
0.062622
0.080235
0.007828
0.007828
0.007828
0.017613
0.052838
0.017613
0.035225
0.041096
0.039139
0.048924
0.017613
0.007828
0.027397
1
4,154
C
C
A
G
A
A
T
G
A
T
A
G
C
A
C
A
G
C
A
G
C
C
G
C
A
A
G
G
C
C
C
A
C
G
C
C
T
G
G
G
A
G
C
G
G
A
A
C
A
C
A
G
A
C
A
C
G
C
G
T
C
C
A
T
T
T
0.011742
0.017613
0.029354
0.019569
0.046967
0.033268
0.017613
0.029354
0.039139
0.033268
0.04501
0.007828
0.019569
0.043053
0.029354
0.048924
0.062622
0.07045
0.046967
0.015656
0.007828
0.009785
0.013699
0.041096
0.021526
0.039139
0.027397
0.060665
0.035225
0.021526
0.015656
0.039139
1
4,155
C
T
G
G
C
T
G
A
A
C
A
T
C
T
A
C
T
A
C
A
T
C
G
T
C
A
T
C
A
T
C
T
C
C
T
G
G
G
C
C
A
T
T
T
A
C
T
A
C
C
T
G
T
A
C
A
A
C
T
C
C
T
T
C
A
T
0.015656
0.017613
0.029354
0.02544
0.054795
0.027397
0.015656
0.027397
0.039139
0.031311
0.048924
0.007828
0.02544
0.046967
0.033268
0.050881
0.054795
0.062622
0.035225
0.011742
0.005871
0.009785
0.015656
0.046967
0.021526
0.035225
0.02544
0.054795
0.041096
0.021526
0.017613
0.043053
1
4,156
G
A
C
G
C
T
G
C
C
C
G
G
G
G
C
C
A
A
G
G
A
G
G
G
C
A
T
C
C
T
C
T
T
C
T
A
C
A
T
C
A
C
A
C
C
C
A
A
C
T
T
C
C
G
C
A
A
G
C
T
G
T
C
T
G
C
0.027397
0.015656
0.046967
0.011742
0.031311
0.033268
0.005871
0.027397
0.037182
0.04501
0.052838
0.017613
0.041096
0.027397
0.029354
0.043053
0.054795
0.056751
0.052838
0.021526
0.001957
0.009785
0.019569
0.041096
0.035225
0.019569
0.031311
0.039139
0.058708
0.019569
0.009785
0.035225
1
4,157
C
T
C
A
T
A
C
G
G
G
C
T
G
G
G
C
C
T
G
G
G
G
T
C
C
C
T
G
A
T
C
G
C
T
C
T
C
G
G
G
A
G
C
T
A
C
A
A
C
T
C
T
T
T
C
C
A
C
A
A
C
A
A
T
G
T
0.035225
0.02544
0.041096
0.011742
0.041096
0.02544
0.003914
0.02544
0.050881
0.052838
0.052838
0.013699
0.027397
0.021526
0.033268
0.035225
0.060665
0.046967
0.052838
0.015656
0.007828
0.007828
0.021526
0.058708
0.027397
0.02544
0.027397
0.04501
0.04501
0.009785
0.017613
0.033268
1
4,158
G
A
A
G
C
C
C
A
C
G
A
T
G
G
A
G
A
A
G
A
T
G
A
C
G
A
A
T
C
C
T
G
C
G
A
A
C
A
T
G
C
T
G
G
T
G
C
A
C
G
A
A
T
T
G
A
T
G
C
A
G
C
A
G
A
G
0.007828
0.011742
0.02544
0.019569
0.039139
0.037182
0.009785
0.019569
0.033268
0.041096
0.052838
0.003914
0.02544
0.060665
0.019569
0.056751
0.060665
0.066536
0.064579
0.011742
0.009785
0.003914
0.015656
0.04501
0.02544
0.023483
0.054795
0.056751
0.037182
0.013699
0.009785
0.037182
1
4,159
C
C
A
T
G
T
C
A
C
C
A
A
G
A
G
G
T
C
C
A
T
T
G
C
T
G
A
T
G
T
G
G
C
G
G
C
C
T
C
A
G
G
T
C
A
G
T
G
C
A
A
C
A
C
T
G
T
G
T
G
G
G
G
C
C
T
0.013699
0.013699
0.021526
0.023483
0.033268
0.039139
0.011742
0.023483
0.027397
0.037182
0.046967
0.011742
0.023483
0.066536
0.021526
0.058708
0.050881
0.068493
0.058708
0.011742
0.009785
0.005871
0.019569
0.04501
0.023483
0.017613
0.054795
0.054795
0.033268
0.017613
0.013699
0.041096
1
4,160
G
A
T
A
G
G
C
A
G
C
T
G
G
G
T
C
A
C
C
G
C
C
T
C
T
G
G
G
T
A
T
G
C
C
A
G
G
A
A
C
G
C
C
A
G
C
C
C
G
G
G
G
C
C
T
G
A
A
C
A
G
A
G
A
A
T
0.056751
0.017613
0.033268
0.023483
0.023483
0.02544
0.001957
0.027397
0.048924
0.035225
0.052838
0.009785
0.021526
0.039139
0.017613
0.033268
0.062622
0.056751
0.068493
0.009785
0.005871
0.009785
0.013699
0.054795
0.043053
0.013699
0.035225
0.052838
0.039139
0.013699
0.013699
0.039139
1
4,161
G
G
C
T
G
A
C
C
T
C
T
G
T
T
C
C
C
A
C
C
T
G
A
A
G
T
T
C
T
G
C
A
C
T
G
T
G
G
A
G
G
G
C
T
T
C
A
T
C
A
C
A
G
C
C
C
T
G
G
T
G
G
A
T
G
T
0.017613
0.017613
0.027397
0.013699
0.023483
0.033268
0.001957
0.023483
0.043053
0.052838
0.07045
0.001957
0.023483
0.031311
0.015656
0.037182
0.088063
0.054795
0.064579
0.009785
0.003914
0.003914
0.005871
0.068493
0.033268
0.015656
0.050881
0.052838
0.048924
0.011742
0.007828
0.04501
1
4,162
G
T
T
C
T
G
C
A
C
T
G
T
G
G
A
G
G
G
C
T
T
C
A
T
C
A
C
A
G
C
C
C
T
G
G
T
G
G
A
T
G
A
G
T
A
C
C
C
C
A
G
G
C
T
C
C
T
C
C
G
C
A
A
C
C
G
0.013699
0.017613
0.027397
0.007828
0.02544
0.035225
0.001957
0.02544
0.04501
0.052838
0.068493
0.003914
0.02544
0.029354
0.015656
0.039139
0.088063
0.054795
0.068493
0.009785
0.003914
0.003914
0.005871
0.07045
0.027397
0.019569
0.046967
0.052838
0.046967
0.011742
0.009785
0.04501
1
4,163
A
A
A
G
A
A
C
A
C
G
A
G
G
A
A
C
A
G
C
A
G
G
C
T
C
A
T
G
C
C
A
C
T
G
G
C
A
G
A
G
T
A
G
T
A
G
T
C
A
A
A
G
A
G
T
T
T
G
A
A
G
A
C
A
T
G
0.041096
0.021526
0.035225
0.054795
0.037182
0.02544
0.005871
0.033268
0.043053
0.017613
0.041096
0.023483
0.023483
0.056751
0.029354
0.033268
0.041096
0.037182
0.043053
0.009785
0.003914
0.003914
0.017613
0.041096
0.050881
0.029354
0.029354
0.023483
0.041096
0.017613
0.031311
0.056751
1
4,164
C
T
C
T
T
T
G
A
C
T
A
C
T
A
C
T
C
T
G
C
C
A
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A
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G
C
C
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C
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G
T
G
T
T
C
T
T
T
G
A
A
T
G
T
G
T
C
T
C
G
0.039139
0.021526
0.035225
0.058708
0.037182
0.02544
0.005871
0.033268
0.041096
0.017613
0.039139
0.023483
0.023483
0.058708
0.029354
0.033268
0.041096
0.037182
0.043053
0.009785
0.003914
0.003914
0.017613
0.039139
0.052838
0.029354
0.027397
0.021526
0.039139
0.017613
0.033268
0.060665
1
4,165
T
T
G
G
A
T
C
C
A
G
G
C
C
C
T
G
C
A
T
C
T
G
G
T
G
G
A
A
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C
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C
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T
C
A
C
A
C
C
A
A
T
C
A
T
T
G
T
G
G
C
G
C
0.02544
0.029354
0.033268
0.023483
0.037182
0.050881
0.001957
0.021526
0.056751
0.021526
0.058708
0.023483
0.02544
0.037182
0.037182
0.033268
0.052838
0.058708
0.052838
0.003914
0.003914
0.001957
0.02544
0.046967
0.033268
0.029354
0.029354
0.033268
0.037182
0.019569
0.017613
0.037182
1
4,166
T
C
T
G
G
T
G
G
A
A
A
C
T
C
T
G
C
T
G
G
T
C
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T
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C
A
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G
T
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G
C
G
G
T
A
A
G
A
A
C
A
A
G
G
C
C
T
G
A
C
A
0.021526
0.029354
0.035225
0.023483
0.039139
0.052838
0.001957
0.021526
0.056751
0.019569
0.058708
0.021526
0.02544
0.039139
0.035225
0.035225
0.052838
0.058708
0.052838
0.003914
0.003914
0.001957
0.023483
0.046967
0.031311
0.031311
0.029354
0.031311
0.039139
0.019569
0.021526
0.035225
1
4,167
T
A
C
G
G
T
C
A
C
G
G
A
A
G
C
A
A
A
C
A
A
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C
A
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A
C
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T
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C
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C
T
C
C
T
G
T
T
G
T
C
A
T
G
C
C
C
G
G
A
T
C
0.09002
0.029354
0.052838
0.052838
0.029354
0.021526
0.011742
0.023483
0.054795
0.027397
0.029354
0.039139
0.019569
0.04501
0.035225
0.019569
0.037182
0.031311
0.013699
0.013699
0.011742
0.001957
0.013699
0.031311
0.062622
0.015656
0.037182
0.027397
0.02544
0.021526
0.035225
0.039139
1
4,168
G
G
C
A
G
C
A
G
C
G
G
A
C
C
G
G
C
T
C
C
A
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A
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T
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C
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G
G
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T
T
G
T
T
G
C
T
T
T
T
G
C
A
G
A
G
G
T
T
T
0.052838
0.037182
0.031311
0.027397
0.054795
0.037182
0.003914
0.017613
0.060665
0.027397
0.041096
0.031311
0.027397
0.035225
0.043053
0.04501
0.050881
0.050881
0.027397
0.009785
0.001957
0.007828
0.011742
0.048924
0.041096
0.019569
0.027397
0.031311
0.033268
0.011742
0.011742
0.041096
1
4,169
C
C
C
C
A
G
C
T
C
C
T
T
G
C
T
G
C
T
T
T
G
G
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C
A
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A
C
A
A
C
A
A
A
T
G
T
G
T
C
A
A
A
T
C
C
C
T
0.080235
0.021526
0.048924
0.056751
0.041096
0.023483
0
0.029354
0.031311
0.04501
0.023483
0.046967
0.031311
0.046967
0.048924
0.027397
0.039139
0.043053
0.021526
0.001957
0.003914
0.001957
0.019569
0.021526
0.02544
0.02544
0.033268
0.021526
0.023483
0.019569
0.050881
0.04501
1
4,170
A
T
T
T
G
A
C
A
C
A
T
T
T
G
T
T
G
T
C
A
T
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A
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A
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A
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G
T
C
T
G
A
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A
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G
C
A
G
C
A
A
G
G
A
G
C
T
G
G
G
G
A
C
T
C
0.080235
0.023483
0.048924
0.054795
0.041096
0.023483
0
0.029354
0.031311
0.04501
0.023483
0.04501
0.031311
0.046967
0.048924
0.027397
0.039139
0.043053
0.021526
0.001957
0.003914
0.001957
0.019569
0.021526
0.02544
0.02544
0.033268
0.021526
0.023483
0.019569
0.052838
0.04501
1
4,171
C
C
A
G
G
G
C
T
C
C
T
G
C
A
A
T
C
A
C
G
G
C
C
A
G
T
C
C
T
G
G
A
C
G
A
C
T
C
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A
G
T
G
C
A
C
T
G
C
T
G
G
T
C
C
A
A
G
G
T
C
C
G
G
T
0.074364
0.037182
0.037182
0.039139
0.039139
0.02544
0.009785
0.039139
0.050881
0.029354
0.029354
0.027397
0.031311
0.035225
0.052838
0.027397
0.048924
0.037182
0.009785
0.007828
0.001957
0
0.02544
0.037182
0.033268
0.027397
0.037182
0.023483
0.02544
0.021526
0.027397
0.050881
1
4,172
A
T
G
A
G
C
C
T
C
C
A
A
C
C
T
C
T
C
T
T
G
G
G
C
T
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G
T
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C
C
T
C
A
C
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G
T
T
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G
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G
A
T
G
T
G
G
A
A
G
T
G
A
A
A
T
C
A
C
A
A
T
0.050881
0.023483
0.039139
0.043053
0.027397
0.021526
0.007828
0.029354
0.039139
0.035225
0.039139
0.015656
0.039139
0.052838
0.033268
0.029354
0.04501
0.048924
0.046967
0.003914
0.007828
0.003914
0.023483
0.035225
0.039139
0.013699
0.04501
0.029354
0.041096
0.017613
0.033268
0.039139
1
4,173
T
A
A
C
T
T
A
T
A
C
A
T
T
G
C
T
G
G
A
C
G
A
C
T
C
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A
A
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C
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G
T
G
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G
T
G
T
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T
A
T
A
G
G
C
T
G
C
A
C
A
G
T
T
A
A
G
G
A
T
0.09002
0.039139
0.041096
0.056751
0.033268
0.021526
0.007828
0.035225
0.041096
0.019569
0.033268
0.074364
0.031311
0.02544
0.046967
0.029354
0.031311
0.037182
0.003914
0.005871
0.001957
0
0.019569
0.037182
0.04501
0.011742
0.021526
0.013699
0.041096
0.017613
0.04501
0.041096
1
4,174
C
T
T
C
A
A
T
C
A
G
A
A
C
G
T
T
A
G
T
G
C
T
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A
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C
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C
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A
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G
A
T
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A
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C
T
G
A
A
G
G
A
A
A
A
A
A
G
A
A
A
T
G
G
C
A
C
0.076321
0.039139
0.04501
0.052838
0.037182
0.021526
0.007828
0.039139
0.039139
0.019569
0.035225
0.066536
0.031311
0.02544
0.050881
0.031311
0.029354
0.031311
0.011742
0.005871
0.001957
0
0.021526
0.037182
0.037182
0.015656
0.02544
0.013699
0.037182
0.019569
0.050881
0.043053
1
4,175
T
C
C
T
A
A
A
A
G
T
T
T
T
A
G
G
G
C
C
C
A
A
G
A
T
T
A
T
C
A
C
G
T
C
C
A
T
C
C
A
G
A
A
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A
A
C
T
A
T
G
G
C
G
C
T
G
G
A
G
T
T
T
A
C
C
0.052838
0.029354
0.035225
0.052838
0.04501
0.017613
0.009785
0.043053
0.041096
0.027397
0.029354
0.052838
0.017613
0.048924
0.02544
0.031311
0.046967
0.039139
0.011742
0.001957
0.003914
0.007828
0.035225
0.023483
0.048924
0.027397
0.02544
0.023483
0.029354
0.029354
0.043053
0.043053
1
4,176
A
C
T
G
T
C
G
G
A
T
C
C
A
C
A
A
A
A
A
A
A
G
T
A
G
A
A
A
T
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A
A
T
G
T
C
A
G
T
A
C
T
G
T
C
G
G
T
T
T
C
A
G
A
A
A
T
G
C
C
T
T
G
C
A
A
0.091977
0.031311
0.046967
0.04501
0.04501
0.027397
0.001957
0.039139
0.054795
0.017613
0.021526
0.041096
0.029354
0.041096
0.027397
0.029354
0.048924
0.039139
0.011742
0.007828
0.009785
0.003914
0.019569
0.015656
0.04501
0.031311
0.029354
0.019569
0.021526
0.021526
0.050881
0.033268
1
4,177
A
C
A
A
A
A
A
A
A
G
T
A
G
A
A
A
T
A
A
A
T
G
T
C
A
G
T
A
C
T
G
T
C
G
G
T
T
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C
A
G
A
A
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G
C
C
T
T
G
C
A
G
T
G
G
G
G
A
T
G
T
C
T
T
0.09002
0.027397
0.046967
0.043053
0.043053
0.027397
0.001957
0.037182
0.056751
0.017613
0.023483
0.041096
0.029354
0.043053
0.027397
0.029354
0.050881
0.041096
0.011742
0.007828
0.009785
0.003914
0.017613
0.019569
0.041096
0.031311
0.031311
0.021526
0.021526
0.021526
0.048924
0.035225
1
4,178
T
G
A
T
C
T
C
C
T
G
C
A
C
A
G
C
C
T
C
C
A
C
G
G
A
G
C
G
A
A
A
C
T
G
G
C
A
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C
C
C
T
G
A
A
A
G
A
T
G
C
G
G
A
T
G
G
C
C
A
C
C
T
C
T
G
0.072407
0.037182
0.050881
0.031311
0.02544
0.013699
0.011742
0.033268
0.039139
0.035225
0.035225
0.02544
0.039139
0.048924
0.041096
0.023483
0.037182
0.041096
0.02544
0.005871
0.011742
0.005871
0.009785
0.043053
0.039139
0.013699
0.037182
0.031311
0.037182
0.009785
0.041096
0.046967
1
4,179
A
C
T
C
T
G
T
G
A
T
C
T
C
C
T
G
C
A
C
A
G
C
C
T
C
C
A
C
G
G
A
G
C
G
A
A
A
C
T
G
G
C
A
G
C
C
C
T
G
A
A
A
G
A
T
G
C
G
G
A
T
G
G
C
C
T
0.072407
0.037182
0.050881
0.029354
0.027397
0.013699
0.011742
0.033268
0.039139
0.035225
0.035225
0.023483
0.039139
0.048924
0.041096
0.02544
0.039139
0.041096
0.02544
0.005871
0.011742
0.005871
0.009785
0.043053
0.041096
0.013699
0.037182
0.031311
0.037182
0.009785
0.035225
0.048924
1
4,180
G
G
C
A
T
A
C
T
C
T
G
T
G
A
T
C
T
C
C
T
G
C
A
C
A
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C
C
T
C
C
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G
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A
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C
T
G
G
C
A
G
C
C
C
T
G
A
A
A
G
A
T
G
C
G
G
A
T
0.072407
0.039139
0.050881
0.029354
0.027397
0.013699
0.011742
0.035225
0.037182
0.033268
0.035225
0.023483
0.037182
0.046967
0.043053
0.02544
0.039139
0.041096
0.02544
0.005871
0.011742
0.005871
0.009785
0.043053
0.043053
0.013699
0.035225
0.031311
0.037182
0.009785
0.035225
0.050881
1
4,181
A
G
G
G
A
G
T
T
T
C
T
A
A
A
G
A
G
C
C
T
G
C
G
A
A
A
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C
C
T
T
T
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C
T
T
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G
G
A
G
C
C
C
A
A
G
T
T
T
G
A
G
T
T
T
G
C
A
0.060665
0.021526
0.050881
0.039139
0.027397
0.017613
0.009785
0.039139
0.039139
0.023483
0.031311
0.023483
0.039139
0.050881
0.046967
0.041096
0.031311
0.052838
0.019569
0.005871
0.011742
0.007828
0.011742
0.039139
0.035225
0.021526
0.039139
0.039139
0.033268
0.011742
0.027397
0.050881
1
4,182
C
T
G
T
T
G
T
G
T
T
T
T
C
C
A
T
A
T
G
T
G
C
T
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C
C
C
C
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A
C
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T
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C
T
G
A
A
T
G
T
G
A
A
G
C
C
C
A
T
T
G
A
A
T
0.046967
0.02544
0.043053
0.023483
0.046967
0.031311
0.007828
0.017613
0.052838
0.056751
0.046967
0.011742
0.029354
0.02544
0.043053
0.02544
0.072407
0.039139
0.035225
0.009785
0
0.005871
0.019569
0.037182
0.035225
0.031311
0.035225
0.027397
0.037182
0.021526
0.013699
0.04501
1
4,183
C
T
T
C
A
A
T
G
G
G
C
T
T
C
A
C
A
T
T
C
A
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C
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C
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G
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C
A
C
A
T
A
T
G
G
A
A
A
A
C
A
C
A
A
C
A
T
0.046967
0.02544
0.043053
0.023483
0.046967
0.031311
0.007828
0.017613
0.052838
0.056751
0.046967
0.011742
0.029354
0.02544
0.043053
0.02544
0.074364
0.039139
0.035225
0.009785
0
0.005871
0.019569
0.037182
0.035225
0.031311
0.035225
0.027397
0.037182
0.021526
0.013699
0.043053
1
4,184
C
C
T
C
T
G
A
A
A
A
A
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G
G
C
A
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G
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G
A
G
A
C
T
T
A
0.064579
0.02544
0.048924
0.054795
0.043053
0.021526
0.003914
0.035225
0.052838
0.02544
0.033268
0.031311
0.023483
0.035225
0.046967
0.02544
0.041096
0.035225
0.027397
0.003914
0.001957
0.001957
0.019569
0.037182
0.04501
0.023483
0.033268
0.013699
0.037182
0.033268
0.037182
0.037182
1
4,185
T
C
T
T
A
C
C
T
T
C
T
C
A
T
A
G
T
A
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A
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C
T
G
A
A
A
A
T
T
0.109589
0.031311
0.039139
0.054795
0.080235
0.021526
0.003914
0.031311
0.041096
0.017613
0.029354
0.033268
0.017613
0.035225
0.046967
0.056751
0.027397
0.019569
0.011742
0.003914
0.005871
0.001957
0.021526
0.031311
0.039139
0.019569
0.029354
0.009785
0.021526
0.029354
0.039139
0.039139
1
4,186
T
C
C
T
G
T
C
T
T
C
C
A
T
T
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A
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G
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C
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A
G
C
C
A
G
0.043053
0.023483
0.052838
0.013699
0.039139
0.027397
0.007828
0.015656
0.054795
0.052838
0.058708
0.013699
0.023483
0.027397
0.031311
0.031311
0.056751
0.035225
0.04501
0.011742
0.009785
0.005871
0.021526
0.050881
0.037182
0.023483
0.04501
0.037182
0.041096
0.013699
0.021526
0.027397
1
4,187
A
T
G
A
G
A
G
C
A
T
T
C
T
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G
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A
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C
0.043053
0.021526
0.052838
0.013699
0.041096
0.027397
0.007828
0.015656
0.054795
0.056751
0.054795
0.013699
0.023483
0.029354
0.031311
0.033268
0.058708
0.037182
0.043053
0.011742
0.009785
0.005871
0.019569
0.050881
0.039139
0.021526
0.043053
0.035225
0.039139
0.015656
0.017613
0.031311
1
4,188
A
A
C
A
G
T
G
A
A
A
A
T
T
G
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A
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C
T
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G
A
G
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G
G
T
T
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T
C
A
G
C
A
G
G
T
0.064579
0.037182
0.050881
0.039139
0.035225
0.035225
0.005871
0.031311
0.054795
0.031311
0.041096
0.021526
0.023483
0.021526
0.041096
0.033268
0.056751
0.04501
0.019569
0.003914
0.001957
0.003914
0.013699
0.037182
0.052838
0.019569
0.029354
0.021526
0.033268
0.015656
0.035225
0.043053
1
4,189
C
T
C
C
T
G
G
A
C
A
T
G
C
A
G
G
T
G
T
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G
G
T
C
A
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T
G
C
C
A
G
G
T
C
0.037182
0.027397
0.021526
0.033268
0.048924
0.033268
0.007828
0.021526
0.037182
0.029354
0.048924
0.007828
0.021526
0.039139
0.037182
0.041096
0.058708
0.056751
0.062622
0.015656
0.007828
0.003914
0.013699
0.041096
0.033268
0.033268
0.039139
0.037182
0.050881
0.009785
0.011742
0.031311
1
4,190
G
C
T
T
A
C
C
G
T
G
C
C
A
T
T
T
A
C
C
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A
C
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A
A
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C
C
G
A
G
T
G
G
A
C
A
G
C
G
0.058708
0.023483
0.056751
0.052838
0.019569
0.017613
0.003914
0.043053
0.043053
0.029354
0.037182
0.054795
0.033268
0.031311
0.035225
0.017613
0.033268
0.039139
0.035225
0.003914
0.003914
0
0.021526
0.041096
0.033268
0.017613
0.017613
0.027397
0.035225
0.02544
0.064579
0.043053
1
4,191
T
C
C
C
A
G
A
G
G
C
A
G
A
G
G
T
C
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A
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T
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C
C
T
G
T
G
G
A
A
0.052838
0.031311
0.041096
0.043053
0.041096
0.041096
0.001957
0.039139
0.043053
0.011742
0.048924
0.037182
0.029354
0.035225
0.037182
0.037182
0.046967
0.037182
0.023483
0
0.003914
0.001957
0.021526
0.033268
0.041096
0.031311
0.021526
0.015656
0.029354
0.02544
0.037182
0.058708
1
4,192
C
C
C
T
C
T
C
C
C
A
G
A
G
G
C
A
G
A
G
G
T
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T
G
G
T
C
A
G
C
A
C
C
A
C
C
C
T
G
C
C
T
T
0.048924
0.029354
0.041096
0.043053
0.041096
0.041096
0.001957
0.039139
0.04501
0.011742
0.048924
0.037182
0.031311
0.037182
0.037182
0.037182
0.046967
0.037182
0.023483
0
0.003914
0.001957
0.021526
0.033268
0.041096
0.031311
0.021526
0.015656
0.029354
0.02544
0.037182
0.058708
1
4,193
A
G
G
T
T
C
C
C
T
C
T
C
C
C
A
G
A
G
G
C
A
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C
C
A
C
A
T
G
G
T
C
A
G
C
A
C
C
A
C
C
C
T
0.054795
0.027397
0.041096
0.046967
0.041096
0.041096
0.001957
0.037182
0.043053
0.011742
0.048924
0.037182
0.031311
0.037182
0.037182
0.037182
0.046967
0.037182
0.023483
0
0.003914
0.001957
0.021526
0.031311
0.039139
0.031311
0.021526
0.015656
0.029354
0.02544
0.037182
0.058708
1
4,194
A
G
G
T
T
C
C
C
T
C
T
C
C
C
A
G
A
G
G
C
A
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C
C
A
C
A
T
G
G
T
C
A
G
C
A
C
C
A
C
C
C
A
0.054795
0.027397
0.041096
0.046967
0.041096
0.041096
0.001957
0.037182
0.043053
0.011742
0.048924
0.037182
0.031311
0.037182
0.037182
0.037182
0.046967
0.037182
0.023483
0
0.003914
0.001957
0.021526
0.031311
0.039139
0.031311
0.021526
0.015656
0.029354
0.02544
0.037182
0.058708
1
4,195
A
A
G
G
T
T
C
C
C
T
C
T
C
C
C
A
G
A
G
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C
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T
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A
C
A
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G
G
T
C
A
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C
A
C
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A
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G
0.054795
0.027397
0.041096
0.046967
0.041096
0.041096
0.001957
0.037182
0.043053
0.011742
0.048924
0.037182
0.031311
0.037182
0.037182
0.037182
0.046967
0.037182
0.023483
0
0.003914
0.001957
0.021526
0.031311
0.039139
0.031311
0.021526
0.015656
0.027397
0.02544
0.039139
0.058708
1
4,196
A
A
G
G
T
T
C
C
C
T
C
T
C
C
C
A
G
A
G
G
C
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T
C
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A
C
A
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G
T
C
A
G
C
A
C
C
A
C
C
A
0.054795
0.027397
0.041096
0.046967
0.041096
0.041096
0.001957
0.037182
0.043053
0.011742
0.048924
0.037182
0.031311
0.037182
0.037182
0.037182
0.046967
0.037182
0.023483
0
0.003914
0.001957
0.021526
0.031311
0.039139
0.031311
0.021526
0.015656
0.027397
0.02544
0.039139
0.058708
1
4,197
A
T
C
T
G
A
A
G
G
T
T
C
C
C
T
C
T
C
C
C
A
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T
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A
T
G
T
C
C
A
C
A
T
G
G
T
C
A
G
C
A
T
0.054795
0.02544
0.043053
0.046967
0.041096
0.041096
0.001957
0.035225
0.04501
0.011742
0.048924
0.039139
0.033268
0.037182
0.035225
0.037182
0.04501
0.035225
0.023483
0
0.003914
0.001957
0.021526
0.031311
0.039139
0.031311
0.021526
0.015656
0.027397
0.02544
0.041096
0.058708
1
4,198
C
T
G
A
C
C
A
T
G
T
G
G
A
C
A
T
T
A
G
G
T
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C
G
A
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G
A
G
A
G
G
G
A
A
C
C
T
T
C
A
G
A
T
G
A
A
0.054795
0.02544
0.04501
0.046967
0.041096
0.041096
0.001957
0.035225
0.04501
0.011742
0.048924
0.039139
0.033268
0.037182
0.035225
0.037182
0.04501
0.035225
0.023483
0
0.003914
0.001957
0.021526
0.031311
0.037182
0.031311
0.021526
0.015656
0.027397
0.02544
0.043053
0.056751
1
4,199
G
G
C
C
C
A
C
A
A
A
G
A
G
G
A
C
A
A
G
G
C
T
G
A
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C
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C
A
C
G
C
C
G
T
C
G
C
T
G
G
A
G
C
G
G
C
T
0.003914
0.005871
0.015656
0
0.027397
0.029354
0.021526
0.019569
0.021526
0.064579
0.041096
0
0.013699
0.021526
0.015656
0.035225
0.068493
0.041096
0.09002
0.064579
0.031311
0.050881
0.005871
0.056751
0.001957
0.043053
0.052838
0.078278
0.041096
0.013699
0.003914
0.019569
1
4,200
G
G
G
C
C
C
A
G
T
A
G
T
C
T
G
G
G
G
C
T
G
C
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C
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C
C
G
A
C
T
C
G
G
T
G
C
T
G
G
A
C
G
G
C
T
0.003914
0.005871
0.013699
0
0.027397
0.029354
0.023483
0.023483
0.019569
0.060665
0.04501
0
0.017613
0.023483
0.013699
0.039139
0.076321
0.041096
0.064579
0.060665
0.039139
0.04501
0.005871
0.054795
0.001957
0.04501
0.062622
0.078278
0.039139
0.013699
0.003914
0.021526
1
4,201
A
C
C
C
G
G
T
G
A
C
C
G
G
C
A
G
T
G
T
G
G
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C
A
C
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G
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C
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G
C
A
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A
G
A
C
G
G
C
T
C
C
C
C
A
G
G
C
C
A
G
C
T
0.003914
0.021526
0.031311
0.001957
0.048924
0.035225
0.04501
0.033268
0.013699
0.050881
0.031311
0.001957
0.009785
0.013699
0.037182
0.084149
0.056751
0.058708
0.041096
0.037182
0.017613
0.037182
0.007828
0.031311
0.015656
0.029354
0.064579
0.054795
0.035225
0.027397
0.001957
0.019569
1
4,202
C
C
A
A
G
A
C
G
T
G
C
T
G
G
A
C
C
A
C
A
C
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G
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G
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A
C
G
T
G
C
T
C
A
A
G
G
A
C
A
A
G
T
A
C
T
0.015656
0.017613
0.035225
0.003914
0.037182
0.035225
0.031311
0.02544
0.027397
0.043053
0.048924
0.001957
0.013699
0.013699
0.02544
0.062622
0.062622
0.058708
0.066536
0.031311
0.015656
0.027397
0.013699
0.033268
0.027397
0.029354
0.046967
0.066536
0.037182
0.019569
0.003914
0.021526
1
4,203
G
A
T
G
G
C
G
T
G
G
G
C
C
A
C
G
C
C
G
G
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A
A
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G
A
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G
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A
G
C
C
T
C
C
C
G
G
C
T
C
C
C
T
G
C
G
A
T
0.013699
0.023483
0.037182
0.011742
0.027397
0.029354
0.015656
0.027397
0.031311
0.052838
0.050881
0
0.019569
0.031311
0.039139
0.031311
0.052838
0.048924
0.048924
0.033268
0.021526
0.019569
0.009785
0.062622
0.027397
0.023483
0.041096
0.062622
0.041096
0.019569
0.005871
0.039139
1
4,204
T
T
G
T
C
T
C
C
T
C
T
T
C
T
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A
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T
G
C
C
T
0.013699
0.023483
0.037182
0.011742
0.029354
0.029354
0.015656
0.027397
0.031311
0.050881
0.050881
0.001957
0.019569
0.033268
0.039139
0.033268
0.050881
0.048924
0.050881
0.031311
0.019569
0.019569
0.007828
0.064579
0.02544
0.023483
0.039139
0.058708
0.043053
0.021526
0.007828
0.039139
1
4,205
C
C
A
G
C
G
G
C
C
A
T
T
G
C
G
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A
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T
G
A
G
C
C
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T
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C
T
A
T
G
A
T
0.007828
0.013699
0.021526
0.013699
0.021526
0.035225
0.009785
0.033268
0.050881
0.039139
0.050881
0.011742
0.019569
0.029354
0.017613
0.041096
0.072407
0.056751
0.068493
0.021526
0.011742
0.019569
0.015656
0.062622
0.02544
0.031311
0.048924
0.052838
0.043053
0.013699
0.005871
0.033268
1
4,206
T
A
A
G
G
C
G
C
C
A
A
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A
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A
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T
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C
T
G
T
C
G
G
T
0.021526
0.015656
0.035225
0.019569
0.043053
0.029354
0.009785
0.031311
0.02544
0.048924
0.041096
0.007828
0.02544
0.041096
0.039139
0.043053
0.048924
0.058708
0.052838
0.023483
0.009785
0.015656
0.011742
0.050881
0.017613
0.033268
0.031311
0.041096
0.052838
0.021526
0.013699
0.039139
1
4,207
C
C
T
G
A
A
A
G
C
C
T
T
T
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C
C
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G
A
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C
G
T
G
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T
G
G
C
T
G
G
C
T
0.029354
0.013699
0.029354
0.007828
0.029354
0.043053
0.007828
0.013699
0.041096
0.048924
0.076321
0.001957
0.019569
0.027397
0.02544
0.046967
0.060665
0.054795
0.04501
0.023483
0.011742
0.007828
0.017613
0.07045
0.023483
0.027397
0.041096
0.058708
0.052838
0.005871
0.001957
0.035225
1
4,208
G
G
T
G
C
A
G
A
T
C
A
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G
A
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G
T
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C
G
A
T
T
C
T
A
C
T
T
A
G
G
T
G
A
G
T
T
0.064579
0.017613
0.035225
0.021526
0.029354
0.031311
0.011742
0.021526
0.048924
0.027397
0.058708
0.013699
0.021526
0.04501
0.015656
0.035225
0.056751
0.043053
0.050881
0.003914
0.007828
0.019569
0.015656
0.048924
0.04501
0.029354
0.033268
0.033268
0.041096
0.011742
0.013699
0.046967
1
4,209
G
G
A
G
G
G
A
G
G
G
G
A
G
T
C
A
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C
C
C
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G
T
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C
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A
G
T
C
A
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A
G
G
0.019569
0.005871
0.046967
0.007828
0.031311
0.037182
0.015656
0.029354
0.035225
0.031311
0.080235
0.011742
0.015656
0.027397
0.02544
0.062622
0.048924
0.04501
0.048924
0.011742
0.003914
0.007828
0.017613
0.064579
0.021526
0.033268
0.046967
0.04501
0.054795
0.011742
0.013699
0.041096
1
4,210
G
G
A
C
T
G
T
G
A
C
G
G
C
T
C
T
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A
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T
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C
C
C
T
G
G
G
T
A
G
G
G
A
T
G
A
C
T
0.019569
0.005871
0.04501
0.007828
0.033268
0.039139
0.015656
0.029354
0.037182
0.033268
0.078278
0.011742
0.013699
0.02544
0.023483
0.064579
0.048924
0.04501
0.048924
0.011742
0.003914
0.007828
0.017613
0.066536
0.021526
0.035225
0.046967
0.041096
0.054795
0.011742
0.013699
0.041096
1
4,211
C
A
G
A
G
C
C
G
T
C
A
C
A
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T
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G
G
T
G
A
C
A
G
T
0.019569
0.005871
0.050881
0.007828
0.035225
0.035225
0.011742
0.02544
0.041096
0.033268
0.078278
0.011742
0.019569
0.031311
0.02544
0.054795
0.04501
0.043053
0.052838
0.011742
0.005871
0.009785
0.017613
0.064579
0.02544
0.035225
0.041096
0.037182
0.060665
0.011742
0.013699
0.037182
1
4,212
G
G
T
G
A
C
C
A
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C
T
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C
A
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A
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T
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A
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G
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G
G
T
G
C
A
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T
C
T
T
G
A
G
A
T
0.019569
0.007828
0.050881
0.007828
0.037182
0.033268
0.007828
0.029354
0.041096
0.035225
0.076321
0.011742
0.019569
0.031311
0.02544
0.052838
0.041096
0.041096
0.056751
0.011742
0.005871
0.009785
0.019569
0.068493
0.02544
0.035225
0.033268
0.035225
0.062622
0.011742
0.015656
0.039139
1
4,213
A
C
A
A
A
G
C
A
T
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C
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C
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A
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T
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C
A
G
A
G
G
T
T
0.037182
0.017613
0.033268
0.027397
0.031311
0.035225
0.009785
0.029354
0.037182
0.037182
0.048924
0.013699
0.017613
0.027397
0.023483
0.060665
0.060665
0.064579
0.04501
0.017613
0.003914
0.007828
0.019569
0.039139
0.039139
0.019569
0.04501
0.050881
0.04501
0.007828
0.015656
0.031311
1
4,214
C
C
T
G
G
A
G
C
C
T
C
A
C
C
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C
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T
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T
T
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C
C
T
C
A
G
T
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G
C
T
G
A
G
G
G
G
0.050881
0.039139
0.039139
0.050881
0.048924
0.029354
0.005871
0.021526
0.04501
0.011742
0.037182
0.02544
0.043053
0.068493
0.029354
0.023483
0.04501
0.048924
0.017613
0.005871
0
0.003914
0.013699
0.017613
0.056751
0.021526
0.019569
0.019569
0.04501
0.023483
0.043053
0.048924
1
4,215
A
C
A
T
A
T
C
T
C
C
C
C
T
G
A
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C
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G
A
G
G
A
A
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G
G
T
G
T
A
A
A
T
0.054795
0.031311
0.027397
0.02544
0.035225
0.04501
0.009785
0.021526
0.02544
0.035225
0.052838
0.017613
0.033268
0.033268
0.04501
0.041096
0.041096
0.052838
0.039139
0.015656
0.007828
0.013699
0.021526
0.04501
0.019569
0.015656
0.029354
0.043053
0.035225
0.023483
0.019569
0.043053
1
4,216
C
C
A
C
C
A
A
G
A
A
C
A
T
A
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G
G
A
G
C
A
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C
T
A
G
A
G
G
A
A
A
A
A
A
A
0.054795
0.031311
0.029354
0.02544
0.037182
0.04501
0.009785
0.019569
0.027397
0.033268
0.052838
0.017613
0.033268
0.037182
0.04501
0.041096
0.039139
0.052838
0.039139
0.015656
0.007828
0.013699
0.021526
0.043053
0.021526
0.015656
0.027397
0.041096
0.035225
0.023483
0.019569
0.043053
1
4,217
A
T
T
G
G
C
C
A
C
C
A
A
G
A
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A
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A
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G
C
G
C
T
G
G
A
G
C
A
C
C
T
A
G
A
G
G
A
G
0.056751
0.031311
0.029354
0.02544
0.037182
0.04501
0.009785
0.019569
0.027397
0.031311
0.052838
0.017613
0.033268
0.037182
0.04501
0.041096
0.039139
0.052838
0.039139
0.015656
0.007828
0.013699
0.021526
0.041096
0.021526
0.015656
0.027397
0.041096
0.035225
0.023483
0.019569
0.04501
1
4,218
G
G
G
C
A
C
C
T
T
G
G
G
T
C
A
C
T
G
C
T
A
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A
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C
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A
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A
T
T
G
G
C
C
A
C
C
A
A
G
A
A
C
A
T
A
T
C
A
0.058708
0.031311
0.031311
0.02544
0.041096
0.04501
0.007828
0.019569
0.033268
0.029354
0.048924
0.02544
0.037182
0.037182
0.048924
0.039139
0.039139
0.050881
0.037182
0.011742
0.005871
0.009785
0.021526
0.039139
0.019569
0.021526
0.027397
0.035225
0.031311
0.023483
0.019569
0.046967
1
4,219
C
C
A
A
G
G
T
G
C
C
C
A
A
A
A
G
A
T
G
G
G
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G
T
G
T
T
C
A
G
C
A
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A
A
T
G
G
A
A
C
G
0.04501
0.037182
0.037182
0.019569
0.043053
0.046967
0.005871
0.021526
0.035225
0.029354
0.050881
0.023483
0.037182
0.041096
0.054795
0.039139
0.041096
0.052838
0.037182
0.007828
0.005871
0.007828
0.013699
0.043053
0.023483
0.019569
0.029354
0.031311
0.031311
0.021526
0.015656
0.050881
1
4,220
C
T
G
C
C
T
C
A
A
A
G
T
A
G
A
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G
T
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T
T
C
C
A
T
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C
T
G
A
A
C
A
C
G
T
0.050881
0.033268
0.043053
0.023483
0.043053
0.039139
0.003914
0.019569
0.033268
0.035225
0.050881
0.023483
0.037182
0.041096
0.060665
0.033268
0.04501
0.048924
0.031311
0.005871
0.005871
0.007828
0.011742
0.039139
0.02544
0.017613
0.039139
0.035225
0.031311
0.021526
0.013699
0.048924
1
4,221
T
C
A
G
C
A
A
T
A
A
T
G
G
A
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C
C
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C
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C
T
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G
A
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C
A
G
C
A
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T
C
T
0.050881
0.035225
0.043053
0.023483
0.043053
0.039139
0.007828
0.019569
0.033268
0.035225
0.048924
0.023483
0.037182
0.041096
0.062622
0.033268
0.043053
0.048924
0.031311
0.005871
0.005871
0.007828
0.011742
0.039139
0.02544
0.015656
0.039139
0.035225
0.029354
0.021526
0.013699
0.048924
1
4,222
G
A
A
C
C
C
T
T
G
T
T
G
A
C
C
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C
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C
A
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C
A
T
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C
G
A
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G
T
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C
C
T
C
T
T
T
0.050881
0.037182
0.043053
0.023483
0.043053
0.037182
0.007828
0.019569
0.035225
0.039139
0.046967
0.023483
0.033268
0.037182
0.062622
0.031311
0.046967
0.048924
0.031311
0.005871
0.005871
0.007828
0.013699
0.037182
0.027397
0.015656
0.041096
0.037182
0.027397
0.021526
0.015656
0.04501
1
4,223
T
G
C
C
A
G
C
A
A
A
G
G
G
G
G
T
A
T
C
A
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G
A
A
C
A
T
C
G
A
A
T
G
C
T
G
C
C
T
C
A
C
0.04501
0.039139
0.04501
0.023483
0.043053
0.039139
0.007828
0.021526
0.037182
0.035225
0.043053
0.02544
0.033268
0.043053
0.060665
0.033268
0.04501
0.054795
0.031311
0.003914
0.005871
0.005871
0.013699
0.033268
0.031311
0.019569
0.039139
0.033268
0.029354
0.019569
0.013699
0.04501
1
4,224
A
T
C
A
A
A
G
C
A
T
G
T
G
A
A
G
A
T
G
C
C
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C
A
A
A
G
G
T
G
A
T
G
A
G
A
T
C
C
A
C
T
T
T
0.035225
0.037182
0.04501
0.019569
0.04501
0.039139
0.007828
0.023483
0.039139
0.035225
0.043053
0.023483
0.033268
0.041096
0.062622
0.035225
0.046967
0.058708
0.035225
0.003914
0.005871
0.005871
0.013699
0.035225
0.029354
0.021526
0.039139
0.033268
0.031311
0.021526
0.009785
0.043053
1
4,225
C
C
T
T
G
T
A
G
T
C
T
C
T
G
A
G
G
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T
A
T
C
A
A
A
G
C
A
T
G
T
G
A
A
G
A
T
G
C
0.043053
0.035225
0.048924
0.02544
0.04501
0.043053
0.007828
0.023483
0.035225
0.031311
0.039139
0.021526
0.031311
0.04501
0.064579
0.037182
0.043053
0.060665
0.035225
0.003914
0.005871
0.001957
0.009785
0.027397
0.031311
0.02544
0.039139
0.029354
0.031311
0.021526
0.013699
0.043053
1
4,226
A
C
A
A
G
G
T
G
A
A
G
C
A
T
G
T
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T
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T
C
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A
C
T
C
T
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G
G
C
A
G
C
A
A
T
T
G
0.048924
0.037182
0.039139
0.029354
0.041096
0.04501
0.009785
0.023483
0.037182
0.027397
0.035225
0.019569
0.033268
0.046967
0.058708
0.037182
0.046967
0.062622
0.035225
0.005871
0.005871
0.001957
0.007828
0.029354
0.033268
0.023483
0.043053
0.02544
0.031311
0.021526
0.013699
0.043053
1
4,227
T
G
T
A
C
C
C
A
A
C
T
G
C
C
T
G
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A
T
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T
T
G
A
G
A
T
T
C
A
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A
A
A
G
C
T
T
T
T
G
0.052838
0.039139
0.039139
0.029354
0.041096
0.043053
0.009785
0.027397
0.033268
0.027397
0.035225
0.019569
0.029354
0.046967
0.056751
0.037182
0.046967
0.060665
0.033268
0.005871
0.005871
0.001957
0.009785
0.027397
0.033268
0.023483
0.043053
0.02544
0.031311
0.021526
0.019569
0.043053
1
4,228
A
G
C
T
G
C
C
A
G
A
A
C
G
T
T
G
A
T
G
C
C
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C
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T
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G
A
A
T
C
T
C
A
A
T
T
G
C
T
G
C
C
A
A
G
A
G
0.058708
0.033268
0.041096
0.027397
0.037182
0.043053
0.009785
0.027397
0.035225
0.02544
0.039139
0.017613
0.033268
0.043053
0.052838
0.035225
0.046967
0.058708
0.033268
0.007828
0.005871
0.003914
0.009785
0.029354
0.031311
0.023483
0.041096
0.027397
0.035225
0.02544
0.017613
0.043053
1
4,229
G
A
A
A
G
C
T
T
T
T
G
C
T
G
T
T
G
C
C
T
T
T
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G
C
A
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C
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T
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C
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T
G
T
C
C
A
C
C
A
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C
C
A
G
T
T
C
T
G
G
G
0.058708
0.029354
0.041096
0.027397
0.037182
0.037182
0.009785
0.031311
0.035225
0.02544
0.039139
0.017613
0.037182
0.04501
0.048924
0.039139
0.050881
0.058708
0.031311
0.003914
0.005871
0.001957
0.007828
0.031311
0.031311
0.023483
0.043053
0.027397
0.037182
0.023483
0.017613
0.04501
1
4,230
C
A
A
C
A
G
G
T
G
A
A
A
C
G
G
A
C
C
C
A
T
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T
G
T
C
A
G
G
C
G
A
T
C
C
G
T
A
C
T
G
T
G
0.056751
0.019569
0.035225
0.035225
0.033268
0.031311
0.017613
0.027397
0.037182
0.027397
0.039139
0.017613
0.029354
0.043053
0.037182
0.043053
0.050881
0.07045
0.043053
0.003914
0.003914
0.001957
0.005871
0.037182
0.033268
0.027397
0.031311
0.035225
0.046967
0.019569
0.019569
0.039139
1
4,231
T
G
G
A
T
A
A
G
G
T
G
G
G
C
C
T
C
T
C
G
T
A
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A
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T
A
A
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T
G
G
A
A
C
A
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A
C
G
T
G
G
A
G
A
T
A
G
G
0.048924
0.017613
0.039139
0.02544
0.046967
0.031311
0.015656
0.035225
0.035225
0.015656
0.050881
0.021526
0.031311
0.035225
0.02544
0.054795
0.050881
0.052838
0.048924
0.005871
0.007828
0.001957
0.011742
0.033268
0.039139
0.031311
0.021526
0.031311
0.046967
0.02544
0.015656
0.04501
1
4,232
C
G
A
G
A
G
G
C
C
C
A
C
C
T
T
A
T
C
C
A
A
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A
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C
T
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C
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C
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T
G
A
T
G
G
G
C
T
T
C
A
C
A
C
A
G
T
A
C
A
0.046967
0.013699
0.043053
0.023483
0.04501
0.029354
0.015656
0.037182
0.031311
0.021526
0.052838
0.023483
0.029354
0.033268
0.023483
0.050881
0.052838
0.054795
0.048924
0.005871
0.007828
0.001957
0.013699
0.033268
0.041096
0.033268
0.013699
0.033268
0.050881
0.02544
0.015656
0.046967
1
4,233
G
G
A
T
G
T
A
G
T
A
A
G
T
G
C
C
A
T
G
T
A
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C
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A
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C
C
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G
G
G
C
A
T
A
C
A
G
C
T
C
T
T
T
G
A
0.046967
0.013699
0.043053
0.023483
0.046967
0.027397
0.013699
0.035225
0.033268
0.02544
0.056751
0.021526
0.027397
0.029354
0.023483
0.050881
0.058708
0.052838
0.046967
0.003914
0.007828
0.001957
0.013699
0.035225
0.041096
0.033268
0.013699
0.037182
0.048924
0.02544
0.013699
0.046967
1
4,234
G
C
C
A
A
G
A
C
C
C
C
C
A
C
A
C
C
T
G
A
C
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C
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A
G
T
G
C
C
A
T
G
T
A
C
T
G
T
G
T
G
A
A
T
0.031311
0.011742
0.043053
0.019569
0.04501
0.029354
0.013699
0.031311
0.039139
0.029354
0.054795
0.02544
0.023483
0.033268
0.023483
0.050881
0.054795
0.056751
0.048924
0.005871
0.005871
0.005871
0.015656
0.043053
0.041096
0.033268
0.013699
0.041096
0.046967
0.023483
0.009785
0.048924
1
4,235
C
A
G
A
G
G
C
C
A
C
G
G
G
G
A
T
A
T
T
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G
T
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C
T
T
C
C
T
A
T
A
T
C
T
T
T
C
C
T
C
0.033268
0.011742
0.04501
0.015656
0.050881
0.031311
0.009785
0.031311
0.037182
0.031311
0.056751
0.023483
0.017613
0.027397
0.027397
0.048924
0.058708
0.060665
0.056751
0.007828
0.005871
0.007828
0.021526
0.031311
0.035225
0.039139
0.013699
0.048924
0.04501
0.023483
0.009785
0.035225
1
4,236
T
G
T
G
G
G
G
C
A
A
C
T
T
C
A
G
T
A
C
T
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T
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A
C
C
T
C
A
G
G
G
A
T
G
A
C
C
C
T
A
G
A
A
T
0.031311
0.011742
0.050881
0.011742
0.048924
0.027397
0.009785
0.033268
0.039139
0.033268
0.056751
0.023483
0.019569
0.027397
0.02544
0.048924
0.056751
0.058708
0.052838
0.007828
0.005871
0.007828
0.021526
0.033268
0.035225
0.035225
0.017613
0.054795
0.043053
0.023483
0.013699
0.033268
1
4,237
T
G
T
T
T
C
T
G
A
C
C
T
C
A
G
G
G
A
T
G
A
C
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C
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A
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C
C
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A
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C
T
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G
G
C
T
G
G
G
A
G
A
A
T
G
A
C
C
A
C
T
A
T
T
0.035225
0.011742
0.048924
0.011742
0.050881
0.031311
0.005871
0.035225
0.037182
0.029354
0.054795
0.021526
0.019569
0.02544
0.023483
0.054795
0.060665
0.062622
0.056751
0.007828
0.005871
0.007828
0.019569
0.029354
0.037182
0.033268
0.017613
0.050881
0.043053
0.023483
0.013699
0.033268
1
4,238
G
A
G
G
A
A
A
A
G
T
A
G
G
C
T
G
T
C
C
T
C
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G
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C
T
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G
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A
C
G
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C
G
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C
T
C
T
C
T
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T
G
G
G
C
G
C
T
T
G
T
A
T
G
A
G
A
G
G
G
T
0.035225
0.011742
0.04501
0.017613
0.050881
0.031311
0.003914
0.037182
0.041096
0.023483
0.060665
0.017613
0.021526
0.02544
0.021526
0.054795
0.058708
0.054795
0.052838
0.007828
0.007828
0.007828
0.023483
0.035225
0.039139
0.035225
0.017613
0.04501
0.046967
0.021526
0.011742
0.035225
1
4,239
A
A
G
T
A
G
G
C
T
G
T
C
C
T
C
T
G
G
G
C
T
G
G
T
G
A
C
G
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C
G
G
C
T
C
T
C
T
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T
G
G
G
C
G
C
T
T
G
T
A
T
G
A
G
A
G
G
G
A
C
T
A
G
G
T
0.035225
0.013699
0.04501
0.017613
0.048924
0.031311
0.003914
0.035225
0.043053
0.023483
0.060665
0.017613
0.021526
0.02544
0.021526
0.050881
0.058708
0.054795
0.052838
0.007828
0.007828
0.007828
0.023483
0.035225
0.043053
0.035225
0.017613
0.04501
0.046967
0.021526
0.011742
0.035225
1
4,240
C
A
G
T
C
T
T
G
G
G
G
T
C
C
T
C
T
T
C
C
T
T
T
C
G
G
A
G
G
A
T
T
T
C
T
G
A
A
A
G
C
A
A
G
C
C
C
T
G
C
A
A
G
A
A
A
T
G
A
A
A
G
G
C
A
C
0.062622
0.019569
0.064579
0.041096
0.017613
0.027397
0.003914
0.021526
0.046967
0.041096
0.058708
0.029354
0.011742
0.027397
0.029354
0.017613
0.054795
0.027397
0.033268
0.015656
0.009785
0.001957
0.013699
0.037182
0.056751
0.019569
0.056751
0.033268
0.041096
0.013699
0.037182
0.027397
1
4,241
A
G
T
C
T
T
G
G
G
G
T
C
C
T
C
T
T
C
C
T
T
T
C
G
G
A
G
G
A
T
T
T
C
T
G
A
A
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C
A
A
G
C
C
C
T
G
C
A
A
G
A
A
A
T
G
A
A
A
G
G
C
A
C
G
0.064579
0.019569
0.064579
0.041096
0.017613
0.027397
0.003914
0.021526
0.046967
0.041096
0.058708
0.029354
0.011742
0.027397
0.029354
0.017613
0.054795
0.027397
0.033268
0.015656
0.009785
0.001957
0.013699
0.035225
0.056751
0.019569
0.056751
0.033268
0.041096
0.013699
0.037182
0.027397
1
4,242
A
G
C
A
C
A
G
A
A
C
C
A
C
T
T
A
T
G
A
A
A
C
A
C
A
A
C
T
G
A
C
C
T
G
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G
T
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C
T
G
T
T
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A
A
A
G
C
C
A
C
A
C
G
T
G
C
A
A
A
T
A
C
C
C
0.056751
0.039139
0.037182
0.039139
0.033268
0.035225
0.011742
0.037182
0.046967
0.031311
0.037182
0.037182
0.027397
0.02544
0.029354
0.031311
0.056751
0.037182
0.021526
0.003914
0.009785
0.005871
0.027397
0.031311
0.050881
0.021526
0.02544
0.015656
0.027397
0.027397
0.035225
0.046967
1
4,243
A
A
T
C
T
C
T
G
C
C
A
A
G
T
T
T
T
T
A
T
T
C
C
T
T
T
T
C
T
C
T
T
T
C
A
T
T
C
G
C
T
T
C
T
T
T
A
T
G
T
C
T
T
C
A
A
G
A
C
T
A
T
C
T
T
C
0.152642
0.035225
0.060665
0.062622
0.02544
0.007828
0.001957
0.033268
0.056751
0.021526
0.019569
0.07045
0.033268
0.029354
0.043053
0.009785
0.023483
0.023483
0.005871
0
0.001957
0.003914
0.029354
0.017613
0.04501
0.013699
0.021526
0.019569
0.015656
0.009785
0.07045
0.035225
1
4,244
C
A
A
G
A
T
G
G
G
T
G
C
A
T
A
C
A
A
G
T
A
C
A
T
C
C
A
G
G
A
G
C
T
A
T
G
G
A
G
A
A
A
G
A
A
G
C
A
G
T
C
T
G
A
T
G
T
C
A
T
G
C
G
C
T
C
0.039139
0.023483
0.04501
0.017613
0.033268
0.02544
0.013699
0.031311
0.033268
0.054795
0.021526
0.02544
0.02544
0.02544
0.031311
0.033268
0.054795
0.046967
0.043053
0.035225
0.015656
0.037182
0.013699
0.027397
0.033268
0.023483
0.041096
0.041096
0.037182
0.02544
0.021526
0.023483
1
4,245
G
C
C
C
A
C
G
C
A
T
C
T
C
C
C
T
G
T
G
C
T
T
G
T
G
G
A
C
T
G
G
T
T
T
G
G
T
G
A
T
C
C
A
C
T
G
G
G
T
G
T
C
A
G
G
A
T
T
T
C
T
T
C
T
G
G
0.054795
0.023483
0.041096
0.046967
0.039139
0.027397
0.007828
0.035225
0.048924
0.035225
0.031311
0.029354
0.023483
0.021526
0.039139
0.041096
0.046967
0.054795
0.019569
0.011742
0.005871
0.013699
0.02544
0.037182
0.035225
0.027397
0.023483
0.033268
0.037182
0.015656
0.035225
0.031311
1
4,246
A
G
A
A
C
T
C
T
T
C
C
C
C
C
C
T
T
T
G
T
T
C
T
T
G
G
A
A
G
T
G
T
T
C
G
A
G
G
A
T
T
A
G
A
C
T
G
A
C
T
G
G
A
T
T
C
A
T
T
C
T
C
A
T
A
G
0.052838
0.029354
0.043053
0.039139
0.043053
0.023483
0.005871
0.029354
0.041096
0.017613
0.041096
0.021526
0.029354
0.043053
0.041096
0.039139
0.033268
0.041096
0.043053
0.017613
0.009785
0.009785
0.023483
0.029354
0.060665
0.017613
0.033268
0.029354
0.046967
0.015656
0.009785
0.039139
1