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int64
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string
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string
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string
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string
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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C
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T
T
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T
C
A
C
T
T
C
C
A
C
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G
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C
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T
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A
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G
C
T
G
T
C
C
T
C
A
G
C
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G
G
T
A
A
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T
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C
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T
A
G
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T
T
C
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T
T
T
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A
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0
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G
A
T
G
A
T
G
A
T
C
A
A
A
G
G
T
C
A
T
A
A
G
T
T
T
T
T
G
T
T
T
A
T
T
C
T
C
C
T
C
T
T
C
A
C
T
G
T
T
C
C
T
T
T
C
T
G
A
A
A
T
T
C
T
A
C
0.121331
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0
30,984
T
T
A
C
T
T
C
T
T
T
C
A
G
G
C
C
T
G
A
A
T
G
G
C
A
G
T
C
A
G
T
A
T
A
T
C
C
T
T
T
T
A
T
A
G
T
G
C
C
C
T
A
T
G
G
T
C
C
C
C
C
T
C
T
T
C
0.062622
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0
0
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0
30,985
C
C
A
A
A
A
G
T
T
G
A
A
A
A
C
T
C
A
A
G
G
T
G
G
G
T
C
C
A
A
A
G
C
A
A
A
G
A
G
C
A
A
A
A
A
A
G
T
C
A
G
C
A
G
T
T
C
C
T
T
T
G
A
T
G
G
0.082192
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0.062622
0
30,986
T
C
A
A
A
A
A
T
G
A
T
T
T
G
G
C
C
C
T
A
G
C
C
C
T
C
G
T
G
G
G
C
T
T
C
T
C
A
T
T
C
T
T
G
G
G
G
T
G
G
A
A
G
G
G
G
T
G
G
T
T
G
A
G
G
C
0.02544
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0
30,987
G
G
C
A
T
C
A
G
A
C
C
T
T
C
T
T
C
T
C
T
A
G
A
A
C
T
T
T
C
T
T
C
T
G
C
C
C
C
A
T
G
T
G
G
T
G
G
T
C
A
C
T
G
C
C
C
A
G
C
T
C
A
A
G
A
C
0.031311
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0
30,988
G
A
T
A
C
T
G
T
T
T
T
T
T
T
A
C
A
G
G
T
G
C
T
C
T
C
T
G
A
T
A
A
C
A
G
A
C
C
C
A
A
A
G
A
A
A
G
A
G
T
G
G
G
T
A
A
G
T
C
T
C
C
C
T
G
G
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0
0
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30,989
T
G
C
T
T
C
T
G
G
T
C
C
T
C
G
C
T
G
C
T
T
A
T
A
G
C
C
A
A
A
T
A
T
A
A
G
G
T
C
G
A
T
C
C
A
C
T
G
A
T
G
A
A
G
T
T
G
G
C
A
A
G
A
A
A
C
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30,990
T
T
T
A
T
A
T
G
G
A
T
C
A
C
C
A
A
T
A
G
C
A
T
T
C
T
C
T
G
A
G
G
C
G
G
A
G
C
T
T
G
A
T
G
G
A
A
C
T
T
T
A
A
T
G
A
G
A
A
A
G
A
A
A
A
T
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30,991
G
T
G
C
A
T
A
G
T
A
T
T
T
C
A
C
T
T
G
A
C
T
T
T
C
A
A
G
A
G
T
C
T
T
C
T
T
T
T
C
T
T
C
T
T
C
T
A
G
C
T
G
T
T
T
A
A
G
T
A
A
T
G
T
G
C
0.109589
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0.048924
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0
0
0
0.048924
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0.043053
0.017613
0.02544
0.011742
0.013699
0.037182
0.058708
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0
30,992
C
A
G
C
C
A
G
T
C
A
A
A
A
A
G
T
A
A
A
A
T
G
A
A
G
A
G
A
G
G
C
A
C
G
C
C
A
A
C
C
A
C
T
C
C
A
A
A
A
T
T
T
T
G
A
G
T
C
T
T
G
C
A
T
T
T
0.144814
0.043053
0.041096
0.041096
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0.013699
0.052838
0.017613
0.015656
0.02544
0.043053
0.035225
0
30,993
A
G
G
T
G
T
T
T
A
T
C
T
T
C
T
C
T
G
T
A
C
G
G
T
A
T
G
T
G
T
T
G
C
C
T
G
G
T
C
C
T
G
T
T
G
T
C
T
C
T
G
T
A
C
T
T
T
T
T
G
G
C
C
A
A
G
0.062622
0.035225
0.041096
0.041096
0.050881
0.033268
0.013699
0.023483
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0.017613
0.013699
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0.04501
0.027397
0.029354
0.029354
0.021526
0.033268
0.035225
0.037182
0
30,994
T
A
T
C
T
G
G
G
C
A
T
C
A
C
C
A
C
C
A
C
C
A
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G
G
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G
A
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A
C
G
T
A
G
C
A
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G
A
A
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C
T
G
G
A
A
T
C
T
C
A
G
A
A
G
G
T
C
A
A
A
0.033268
0.031311
0.033268
0.019569
0.027397
0.041096
0.019569
0.017613
0.039139
0.039139
0.04501
0.011742
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0.035225
0.035225
0.031311
0.048924
0.054795
0.050881
0.027397
0.017613
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0.04501
0.039139
0.02544
0.029354
0.04501
0.041096
0.015656
0.009785
0.039139
0
30,995
T
T
G
A
A
C
T
T
T
T
T
T
G
T
T
G
G
C
T
T
G
C
A
A
C
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T
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C
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C
G
G
G
T
G
T
G
T
C
T
A
A
A
A
T
T
A
A
A
T
T
G
T
T
G
T
A
G
T
T
A
G
T
0.113503
0.048924
0.043053
0.068493
0.060665
0.009785
0.005871
0.039139
0.04501
0.011742
0.017613
0.058708
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0.037182
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0.017613
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0.009785
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0.031311
0.017613
0.043053
0.015656
0.009785
0.011742
0.013699
0.029354
0.072407
0.039139
0
30,996
T
G
T
C
C
A
G
G
T
C
A
G
T
G
T
A
G
C
G
C
A
G
C
C
A
C
T
T
C
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C
T
C
A
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T
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T
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T
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A
G
C
T
G
G
G
A
T
T
C
C
T
G
T
A
C
C
A
C
C
T
0.015656
0.02544
0.015656
0.015656
0.046967
0.041096
0.013699
0.04501
0.031311
0.035225
0.035225
0.015656
0.02544
0.021526
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0.050881
0.082192
0.068493
0.058708
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0.017613
0.011742
0.017613
0.031311
0.027397
0.04501
0.015656
0.039139
0.039139
0.02544
0.015656
0.039139
0
30,997
T
A
G
A
C
A
C
T
G
A
T
G
T
T
G
C
C
C
A
T
A
T
C
T
C
T
T
T
C
A
C
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C
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C
A
C
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C
A
G
G
C
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C
C
A
A
A
C
A
T
G
G
C
C
A
C
A
T
G
A
G
A
G
0.019569
0.019569
0.029354
0.013699
0.041096
0.029354
0.007828
0.052838
0.039139
0.021526
0.037182
0.015656
0.029354
0.050881
0.021526
0.052838
0.054795
0.062622
0.043053
0.017613
0.007828
0.001957
0.015656
0.050881
0.027397
0.037182
0.027397
0.039139
0.048924
0.021526
0.013699
0.048924
0
30,998
C
C
T
G
C
C
T
G
T
T
G
A
T
A
G
C
C
A
G
G
C
C
C
C
A
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A
A
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C
T
T
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T
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T
G
A
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A
G
T
T
G
A
T
A
G
T
A
A
T
G
G
A
A
G
G
T
G
C
0.037182
0.029354
0.043053
0.031311
0.039139
0.02544
0
0.039139
0.04501
0.021526
0.041096
0.058708
0.041096
0.041096
0.041096
0.035225
0.048924
0.048924
0.023483
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0.023483
0.031311
0.035225
0.021526
0.031311
0.031311
0.033268
0.017613
0.029354
0.046967
0
30,999
A
C
C
C
A
G
G
C
C
A
G
A
C
C
A
G
G
G
C
C
A
C
A
T
G
G
C
G
A
G
T
G
C
G
G
A
T
C
C
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G
A
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G
A
T
G
G
G
G
A
G
C
A
T
G
A
G
C
A
G
T
C
T
T
0.076321
0.039139
0.043053
0.043053
0.037182
0.02544
0.005871
0.029354
0.043053
0.029354
0.031311
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0.033268
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0.050881
0.021526
0.046967
0.043053
0.02544
0.003914
0.009785
0.007828
0.013699
0.027397
0.04501
0.021526
0.035225
0.02544
0.027397
0.015656
0.029354
0.046967
0
31,000
T
G
A
T
G
G
G
C
A
G
A
T
A
G
T
T
A
C
A
A
T
G
A
T
C
C
A
T
A
G
G
A
C
T
G
G
G
G
A
T
G
T
C
C
A
G
T
A
C
A
G
A
T
C
T
T
C
A
G
T
G
A
G
A
T
G
0.076321
0.023483
0.050881
0.056751
0.029354
0.013699
0.005871
0.043053
0.037182
0.013699
0.027397
0.046967
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0.041096
0.033268
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0.017613
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0.064579
0.013699
0.035225
0.017613
0.037182
0.019569
0.02544
0.056751
0
31,001
T
T
T
A
G
C
C
A
C
T
G
C
T
G
C
A
T
C
A
G
C
T
T
C
C
A
C
G
T
C
A
G
T
G
C
C
A
G
T
T
A
G
C
T
G
T
G
G
C
T
C
C
T
C
A
G
C
C
T
C
C
C
T
T
T
C
0.021526
0.027397
0.043053
0.009785
0.029354
0.015656
0.013699
0.043053
0.041096
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0.035225
0.068493
0.046967
0.054795
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0.001957
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0.04501
0.031311
0.021526
0.04501
0.050881
0.043053
0.017613
0.017613
0.043053
0
31,002
G
A
C
A
C
A
C
T
T
T
G
C
C
T
G
T
T
G
G
G
G
C
T
T
T
T
C
T
G
G
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T
T
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A
C
T
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T
T
C
G
G
G
T
T
T
A
T
G
C
T
C
C
T
G
T
T
T
T
C
C
T
G
C
C
0.043053
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0.039139
0.027397
0.027397
0.060665
0.046967
0.009785
0.017613
0.023483
0
31,003
T
G
G
A
C
C
A
A
G
T
T
C
T
G
C
A
C
T
A
A
A
T
C
A
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C
A
C
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C
A
T
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T
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C
T
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C
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G
A
A
G
T
T
T
T
A
G
C
A
T
C
T
C
A
C
G
A
T
T
C
0.111546
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0.019569
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0
0.003914
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0.023483
0.039139
0.013699
0.023483
0
0.013699
0.027397
0.076321
0.046967
0
31,004
C
C
T
G
G
C
C
G
G
G
T
G
G
A
C
T
T
G
C
A
C
A
G
A
A
C
T
G
C
T
G
G
T
G
C
C
A
G
G
T
T
A
G
T
T
C
C
C
T
G
G
G
A
C
T
T
T
T
C
C
A
A
C
A
T
C
0.086106
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0.046967
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0
0.02544
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0.056751
0.023483
0.043053
0.019569
0.033268
0.013699
0.033268
0.033268
0
31,005
T
A
C
T
G
T
G
G
C
T
A
A
C
T
G
C
T
T
A
G
C
A
A
A
T
T
C
C
A
C
A
T
C
C
C
A
A
A
G
T
G
A
A
G
G
T
G
A
T
G
T
G
T
C
T
A
C
A
T
A
A
T
A
A
A
T
0.093933
0.037182
0.041096
0.078278
0.04501
0.017613
0.003914
0.039139
0.033268
0.015656
0.021526
0.058708
0.033268
0.037182
0.048924
0.019569
0.031311
0.029354
0.02544
0
0
0
0.019569
0.015656
0.033268
0.015656
0.021526
0.009785
0.023483
0.033268
0.076321
0.041096
0
31,006
T
A
T
T
T
A
C
T
C
A
C
C
T
T
C
A
T
T
T
T
T
C
A
C
A
A
C
A
T
T
T
A
T
A
A
A
G
G
T
T
C
T
G
A
T
A
A
A
T
C
C
T
G
C
C
T
G
T
T
T
T
C
C
A
G
A
0.088063
0.019569
0.021526
0.041096
0.035225
0.039139
0.009785
0.019569
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0.029354
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0.029354
0.027397
0.015656
0.027397
0.035225
0.029354
0.035225
0.02544
0.043053
0
31,007
C
T
C
C
T
G
A
C
C
T
C
A
A
G
C
A
A
T
C
T
G
C
T
T
G
C
C
T
C
G
G
C
T
T
C
C
C
A
A
A
G
T
G
C
G
G
G
A
T
T
A
C
A
G
G
A
A
T
G
A
G
C
C
A
C
C
0.080235
0.039139
0.023483
0.043053
0.037182
0.02544
0.009785
0.043053
0.050881
0.031311
0.02544
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0.033268
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0.046967
0.033268
0.02544
0.02544
0.021526
0.021526
0.019569
0.039139
0.04501
0
31,008
C
A
A
C
A
T
C
C
A
G
T
G
A
A
C
T
C
T
C
A
G
T
A
A
T
C
A
T
G
T
C
A
T
T
G
G
G
C
T
C
T
T
C
C
A
C
A
C
A
G
G
C
T
A
G
A
C
C
G
G
C
A
T
A
A
C
0.072407
0.033268
0.027397
0.052838
0.048924
0.019569
0.007828
0.023483
0.037182
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0.02544
0.027397
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0.021526
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0.037182
0.013699
0.029354
0.021526
0.035225
0.023483
0.048924
0.043053
0
31,009
G
A
T
G
T
C
T
A
A
A
A
A
G
C
C
A
A
A
C
A
C
A
C
A
G
G
T
G
A
C
G
A
T
T
C
A
T
C
T
C
A
G
C
A
T
C
T
G
A
A
A
T
A
C
A
A
T
A
A
A
C
A
C
A
G
C
0.058708
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0.039139
0.039139
0.043053
0.019569
0.003914
0.029354
0.054795
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0.033268
0.019569
0.035225
0.031311
0.033268
0.023483
0.039139
0.041096
0
31,010
A
A
A
G
A
C
C
A
C
A
T
A
T
G
G
T
A
T
G
A
T
T
C
C
A
T
T
T
A
T
T
T
C
A
A
A
T
G
T
C
C
A
A
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A
A
C
A
G
A
C
A
A
A
T
C
C
A
T
A
G
G
T
A
C
G
0.121331
0.031311
0.046967
0.056751
0.048924
0.031311
0.003914
0.021526
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0.048924
0.017613
0.017613
0.005871
0.023483
0.023483
0.046967
0.037182
0
31,011
T
T
T
T
A
A
G
A
G
A
G
G
C
T
T
C
A
T
A
A
T
T
A
G
T
A
A
C
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A
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T
C
C
T
G
G
A
T
T
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T
A
G
A
A
A
C
C
T
G
T
T
A
A
A
G
A
A
A
C
A
T
A
C
0.113503
0.02544
0.043053
0.09589
0.035225
0.021526
0.003914
0.027397
0.031311
0.023483
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0
0.001957
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0.011742
0.009785
0.007828
0.027397
0.027397
0.093933
0.033268
0
31,012
G
T
T
C
A
T
C
A
G
A
C
A
G
T
T
G
C
A
G
C
T
C
C
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T
A
A
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C
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C
A
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T
C
T
C
T
C
A
G
C
A
G
C
C
T
A
G
A
A
T
0.099804
0.043053
0.039139
0.07045
0.037182
0.021526
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0.035225
0.015656
0.027397
0.021526
0.017613
0.023483
0.068493
0.033268
0
31,013
T
C
C
T
A
A
A
G
A
G
A
T
T
G
T
A
A
A
A
G
T
A
G
A
G
A
A
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A
T
G
A
T
G
G
A
A
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C
C
A
T
G
T
G
T
C
C
C
A
A
G
C
T
T
C
T
G
T
G
A
C
C
A
C
0.066536
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0.02544
0
0.02544
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0.023483
0.029354
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0.064579
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0
31,014
G
G
G
T
A
T
A
T
G
A
G
A
A
A
A
T
A
T
T
G
A
C
T
C
C
T
A
T
C
T
G
G
C
C
T
T
C
A
T
C
A
A
C
T
G
A
C
C
T
C
G
A
A
A
A
G
C
C
T
C
A
T
G
A
G
T
0.103718
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0.04501
0.02544
0.035225
0.017613
0.021526
0.019569
0.04501
0.066536
0
31,015
G
G
G
G
T
G
G
G
G
G
C
C
G
C
T
G
G
C
A
G
G
A
C
T
C
A
C
C
A
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T
C
T
C
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C
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G
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G
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C
G
T
C
G
G
C
G
T
C
T
G
G
C
C
G
T
T
T
G
G
C
0.023483
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0.031311
0.058708
0.035225
0.019569
0.005871
0.029354
0
31,016
A
G
A
G
T
C
A
G
G
C
T
C
C
T
T
T
C
T
T
C
C
C
A
T
A
A
T
C
C
A
G
A
T
G
T
C
A
T
T
G
G
A
A
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G
A
T
G
A
G
T
C
T
A
A
T
A
C
C
A
A
A
A
A
T
C
0.101761
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0.031311
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0.021526
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0.080235
0.029354
0
31,017
C
C
C
C
A
G
G
C
C
A
T
G
T
C
A
A
A
T
C
A
G
T
G
A
C
T
C
A
A
A
A
T
C
C
T
G
C
T
T
C
A
G
A
G
T
A
T
G
T
A
C
A
A
C
A
G
C
A
G
C
C
A
A
T
T
T
0.023483
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0.015656
0.02544
0.050881
0.029354
0
0.039139
0.019569
0.060665
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0.033268
0.105675
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0.023483
0.021526
0.062622
0.048924
0.039139
0.029354
0.007828
0.029354
0
31,018
C
C
C
C
T
G
A
G
C
G
A
C
A
C
T
G
C
C
C
C
G
C
C
G
C
G
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G
A
C
A
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C
T
G
G
A
T
G
T
T
C
T
G
G
G
C
A
A
T
G
C
T
G
C
C
G
C
C
A
C
C
G
C
C
G
0.013699
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0.019569
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0.02544
0.02544
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0.027397
0.048924
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0.035225
0.037182
0.029354
0.064579
0.043053
0.011742
0.009785
0.027397
0
31,019
T
T
A
T
T
G
T
C
T
T
A
T
A
T
G
C
A
G
T
T
G
C
C
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C
A
A
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G
T
C
A
T
T
G
A
C
C
T
T
T
G
C
T
G
G
A
A
A
T
A
A
A
G
T
A
A
C
C
T
C
A
T
T
A
C
0.105675
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0.07045
0.031311
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0
0.033268
0.041096
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0.064579
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0.023483
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0.031311
0.019569
0.052838
0.017613
0.023483
0.013699
0.019569
0.027397
0.056751
0.04501
0
31,020
C
A
T
C
C
C
T
G
T
G
C
T
T
C
T
G
T
G
G
A
T
A
C
T
G
T
A
T
C
T
G
G
C
C
T
G
T
C
C
C
A
T
C
A
G
G
A
A
A
G
A
G
A
A
T
T
T
G
A
T
A
G
A
C
A
G
0.052838
0.019569
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0.023483
0.035225
0.033268
0.009785
0.031311
0.035225
0.027397
0.046967
0.037182
0.033268
0.046967
0.031311
0.031311
0.050881
0.041096
0.048924
0.005871
0.007828
0.003914
0.021526
0.027397
0.033268
0.027397
0.041096
0.02544
0.035225
0.031311
0.019569
0.043053
0
31,021
A
T
C
A
G
A
A
A
C
A
G
A
G
C
A
A
G
A
A
A
C
C
A
C
C
A
C
G
A
A
G
C
T
G
G
C
T
C
C
G
G
A
A
G
G
T
A
A
A
G
T
T
T
A
T
G
A
T
G
A
T
T
T
T
A
C
0.060665
0.033268
0.046967
0.043053
0.02544
0.031311
0.001957
0.02544
0.04501
0.039139
0.035225
0.019569
0.023483
0.039139
0.029354
0.027397
0.052838
0.064579
0.039139
0.005871
0.005871
0.005871
0.015656
0.031311
0.043053
0.005871
0.031311
0.048924
0.02544
0.017613
0.052838
0.027397
0
31,022
C
A
G
A
T
T
C
T
C
T
T
C
C
T
T
C
T
C
C
A
G
A
G
C
C
T
T
T
T
C
C
T
C
T
T
C
T
A
G
A
T
A
T
G
A
T
T
T
C
T
T
C
C
C
C
A
G
A
T
A
C
T
C
C
T
T
0.037182
0.005871
0.072407
0.015656
0.001957
0.017613
0.001957
0.02544
0.097847
0.011742
0.080235
0.048924
0.056751
0.019569
0.007828
0.001957
0.046967
0.048924
0.039139
0
0
0.001957
0.011742
0.084149
0.076321
0
0.009785
0.007828
0.105675
0.039139
0.009785
0.015656
0
31,023
C
C
C
G
G
A
G
G
G
C
C
C
G
G
A
C
A
T
G
T
T
G
C
T
G
A
C
C
A
T
C
T
T
C
C
G
C
A
G
G
G
C
G
C
G
C
A
G
C
T
C
C
T
T
G
G
A
G
T
C
C
T
C
C
T
C
0.005871
0.013699
0.02544
0.001957
0.021526
0.017613
0.007828
0.003914
0.027397
0.076321
0.09002
0
0.005871
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0.017613
0.015656
0.09589
0.02544
0.074364
0.052838
0.011742
0.033268
0.003914
0.072407
0.023483
0.017613
0.078278
0.086106
0.066536
0.003914
0
0.013699
0
31,024
T
C
C
A
G
A
C
T
C
T
C
A
G
T
T
C
T
C
T
C
G
G
A
T
T
T
A
T
T
T
G
T
T
T
C
T
T
C
A
A
A
T
C
C
C
T
G
C
A
C
A
G
A
T
C
C
C
A
G
A
T
C
T
T
T
A
0.078278
0.02544
0.050881
0.041096
0.033268
0.011742
0.007828
0.033268
0.103718
0.013699
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0.029354
0.060665
0.062622
0.02544
0.019569
0.011742
0.039139
0.011742
0.023483
0.031311
0
31,025
A
G
C
C
A
G
T
G
A
A
G
C
A
G
T
T
C
G
T
G
C
T
A
T
T
G
A
G
A
A
A
A
T
T
A
G
T
A
A
A
A
A
T
A
C
C
A
G
G
T
A
T
A
C
A
C
A
T
G
G
C
C
A
T
G
C
0.099804
0.029354
0.04501
0.088063
0.048924
0.013699
0.001957
0.033268
0.046967
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0.062622
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0.041096
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0.027397
0.019569
0.003914
0
0.001957
0
0.043053
0.011742
0.048924
0.007828
0.021526
0.015656
0.003914
0.037182
0.076321
0.039139
0
31,026
T
C
C
A
C
A
G
T
C
A
A
T
C
C
A
T
A
T
G
G
C
A
T
T
T
T
T
G
G
C
T
G
C
T
T
G
T
T
C
T
T
T
T
C
C
A
G
A
A
A
C
C
T
G
C
T
C
A
A
A
G
A
A
A
C
T
0.084149
0.033268
0.050881
0.060665
0.031311
0.021526
0
0.039139
0.041096
0.033268
0.023483
0.043053
0.02544
0.04501
0.043053
0.029354
0.039139
0.037182
0.015656
0
0
0
0.02544
0.021526
0.054795
0.013699
0.037182
0.015656
0.023483
0.015656
0.04501
0.050881
0
31,027
T
T
C
T
A
G
C
C
T
T
T
T
T
T
C
A
G
T
A
T
A
A
A
C
A
T
C
T
T
T
C
A
T
A
G
T
T
T
T
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A
A
C
T
T
T
C
T
T
G
A
A
C
T
T
T
C
C
A
T
T
T
T
G
T
C
0.105675
0.041096
0.046967
0.041096
0.035225
0.017613
0.003914
0.048924
0.046967
0.023483
0.023483
0.037182
0.039139
0.031311
0.037182
0.027397
0.039139
0.033268
0.009785
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0.011742
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0.029354
0.027397
0.054795
0.011742
0.023483
0.013699
0.029354
0.02544
0.037182
0.043053
0
31,028
C
C
A
C
T
G
T
C
C
T
T
C
T
G
G
T
T
T
C
A
T
A
G
A
T
A
C
A
G
T
C
A
T
A
G
G
T
G
G
A
G
G
G
C
T
T
G
G
C
A
C
T
G
T
T
G
C
A
C
T
T
A
A
G
T
C
0.097847
0.048924
0.048924
0.031311
0.035225
0.029354
0.001957
0.046967
0.043053
0.023483
0.037182
0.031311
0.017613
0.029354
0.046967
0.021526
0.039139
0.035225
0.019569
0.003914
0.005871
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0.027397
0.035225
0.043053
0.013699
0.031311
0.019569
0.02544
0.029354
0.041096
0.035225
0
31,029
C
T
C
A
T
T
C
C
T
T
G
A
C
T
C
A
T
G
G
C
T
C
C
C
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C
C
T
C
C
A
T
C
T
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C
A
A
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C
A
A
A
A
G
C
A
A
G
T
C
A
A
G
T
C
C
T
C
A
0.050881
0.031311
0.046967
0.056751
0.027397
0.019569
0
0.029354
0.052838
0.031311
0.041096
0.037182
0.031311
0.046967
0.039139
0.009785
0.046967
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0.023483
0.037182
0.050881
0.019569
0.033268
0.02544
0.035225
0.015656
0.04501
0.046967
0
31,030
G
C
C
T
C
A
T
T
C
C
T
T
G
A
C
T
C
A
T
G
G
C
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A
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A
A
C
A
A
A
A
G
C
A
A
G
T
C
A
A
G
T
C
C
T
0.050881
0.031311
0.046967
0.056751
0.027397
0.019569
0
0.029354
0.054795
0.031311
0.041096
0.037182
0.031311
0.046967
0.039139
0.009785
0.048924
0.035225
0.02544
0.003914
0
0
0.023483
0.037182
0.050881
0.019569
0.033268
0.02544
0.035225
0.015656
0.04501
0.046967
0
31,031
T
A
A
T
T
T
G
A
G
T
A
A
G
T
T
G
T
T
G
T
G
G
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A
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A
A
A
A
A
C
A
A
G
G
A
T
G
A
G
T
G
A
A
A
G
0.107632
0.039139
0.041096
0.088063
0.052838
0.015656
0
0.043053
0.023483
0.013699
0.015656
0.046967
0.023483
0.048924
0.050881
0.029354
0.023483
0.027397
0.011742
0
0.001957
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0.013699
0.017613
0.050881
0.011742
0.013699
0.007828
0.019569
0.031311
0.068493
0.058708
0
31,032
A
A
A
A
G
A
C
T
G
T
T
C
A
A
C
A
T
G
C
C
T
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C
T
A
T
T
A
T
T
G
G
T
G
A
C
A
T
T
G
T
T
T
T
A
T
0.084149
0.043053
0.037182
0.035225
0.060665
0.017613
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0
31,033
A
G
T
C
T
C
A
G
G
A
T
A
T
G
G
G
G
A
G
G
T
G
G
C
C
A
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A
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C
C
C
A
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G
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T
T
G
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G
C
A
G
A
G
A
C
A
C
C
C
G
A
T
G
A
G
A
G
T
T
0.033268
0.015656
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0.02544
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0.027397
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0.043053
0.039139
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0.007828
0.043053
0
31,034
A
T
G
A
C
T
G
C
T
C
A
A
T
G
G
T
T
G
C
T
C
T
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G
G
A
A
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C
A
G
C
A
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T
C
T
G
A
A
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G
G
C
T
T
C
T
A
A
A
G
A
C
A
A
T
A
G
C
G
A
C
T
0.088063
0.035225
0.041096
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0.050881
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0.048924
0.027397
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0.023483
0.019569
0.015656
0.015656
0.050881
0
31,035
G
C
G
G
C
A
T
G
A
G
A
A
C
T
T
A
C
A
T
T
T
G
T
C
T
T
C
A
G
G
G
T
C
C
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C
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A
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G
A
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A
C
A
T
T
T
G
T
T
A
T
T
C
T
G
T
G
A
C
T
T
0.062622
0.029354
0.039139
0.052838
0.046967
0.013699
0.001957
0.027397
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0.015656
0.041096
0.02544
0.033268
0.021526
0.043053
0.039139
0
31,036
G
T
T
C
T
G
G
T
C
C
C
A
G
A
G
A
A
C
T
T
G
C
C
A
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A
A
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A
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T
C
A
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A
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T
T
A
C
A
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T
T
T
A
T
C
C
T
G
C
A
C
A
T
A
T
T
A
T
T
T
C
T
0.113503
0.035225
0.033268
0.084149
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0
0
0.037182
0.023483
0.052838
0.013699
0.029354
0.013699
0.02544
0.019569
0.062622
0.035225
0
31,037
T
A
G
C
T
G
G
G
T
A
T
G
G
T
G
C
C
A
C
G
C
A
C
C
T
G
T
A
G
T
C
C
T
A
G
C
T
A
C
T
C
C
T
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G
G
G
A
G
G
T
T
G
A
G
G
C
G
G
G
A
G
G
A
T
C
0.062622
0.013699
0.021526
0.031311
0.086106
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0.035225
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0.021526
0.037182
0.029354
0.027397
0.039139
0.023483
0.033268
0
31,038
C
T
T
T
A
T
C
T
T
C
A
A
G
A
G
A
G
A
G
A
A
T
T
T
C
C
T
T
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T
T
T
T
C
T
G
T
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T
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T
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T
T
A
A
A
A
T
A
A
A
T
T
A
T
T
C
A
T
T
A
G
C
0.091977
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0.07045
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0.013699
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0
0.023483
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0.02544
0.02544
0.015656
0.019569
0.015656
0.050881
0.041096
0
31,039
C
T
C
C
C
C
T
C
A
A
G
A
G
A
T
C
G
C
G
T
C
T
A
T
T
C
G
G
A
A
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G
C
G
T
G
T
G
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C
T
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G
G
C
A
C
C
T
C
A
G
C
C
A
G
T
G
A
A
G
C
A
C
T
0.082192
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0.054795
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0.056751
0.027397
0.011742
0.019569
0.031311
0.021526
0.039139
0.050881
0
31,040
T
A
G
C
T
G
G
G
A
C
T
A
C
A
G
G
C
G
C
C
C
G
C
C
A
C
C
A
C
G
C
C
T
A
G
C
T
A
A
T
T
T
T
T
T
T
G
T
A
T
T
T
T
T
A
G
T
A
G
A
G
A
C
G
G
C
0.093933
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0.023483
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0.02544
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0.02544
0.04501
0.031311
0.019569
0.02544
0.035225
0
31,041
G
G
T
G
C
C
A
C
T
G
T
G
C
T
C
C
A
G
C
C
T
G
G
G
G
G
A
C
A
G
A
G
C
G
A
G
A
C
T
C
G
C
C
T
G
A
A
A
A
A
A
A
A
A
A
G
A
A
A
A
A
A
A
A
G
T
0.097847
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0.029354
0.035225
0.027397
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0.007828
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0.037182
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0.043053
0.029354
0.021526
0.029354
0.037182
0.02544
0.02544
0.021526
0.041096
0
31,042
T
C
A
A
C
C
C
T
T
G
T
C
A
C
T
T
T
C
C
C
T
T
T
G
T
C
T
C
C
A
G
G
C
C
C
T
G
G
G
A
T
T
G
G
C
T
G
A
A
G
A
C
A
G
A
G
C
C
A
G
G
T
C
C
T
T
0.048924
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0.043053
0.033268
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0.027397
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0.02544
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0.029354
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0.046967
0.02544
0.031311
0.013699
0.031311
0.031311
0
31,043
C
T
G
G
T
A
G
A
A
C
C
T
G
A
G
G
C
T
G
T
C
A
G
C
A
T
A
G
T
T
G
T
C
G
T
A
G
C
G
A
C
A
G
T
A
G
A
C
G
G
T
G
A
A
G
C
G
C
A
C
G
A
T
T
T
G
0.017613
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0.033268
0.023483
0.068493
0.064579
0.048924
0.013699
0
0.019569
0
31,044
C
G
C
G
C
C
C
T
G
G
G
C
C
T
C
G
G
A
G
C
G
C
A
G
G
C
G
G
T
C
C
C
C
G
A
A
C
C
T
G
G
C
G
T
G
G
A
A
C
C
C
C
G
G
C
A
T
C
G
C
C
T
G
C
C
T
0.054795
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0.043053
0.017613
0.02544
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0.003914
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0.017613
0.046967
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0.039139
0.019569
0.043053
0.058708
0.043053
0.001957
0.015656
0.031311
0
31,045
T
T
C
T
G
C
A
C
A
T
T
G
T
G
G
A
C
T
T
G
T
C
T
G
A
T
C
C
C
A
A
G
C
A
A
A
T
C
T
G
G
A
A
A
T
T
T
G
T
T
G
A
A
A
A
T
T
T
C
A
A
G
C
A
G
A
0.1409
0.037182
0.04501
0.056751
0.043053
0.011742
0.009785
0.031311
0.037182
0.017613
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0.046967
0.041096
0.021526
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0.039139
0.013699
0.007828
0
0.001957
0.015656
0.019569
0.043053
0.015656
0.021526
0.009785
0.039139
0.021526
0.054795
0.027397
0
31,046
G
G
G
A
G
G
A
A
G
A
G
A
A
A
A
C
T
T
T
C
T
G
G
A
A
A
A
A
G
T
A
C
C
G
C
A
C
T
T
T
C
T
G
G
A
A
G
G
A
G
G
A
T
A
A
G
G
C
C
T
T
C
T
G
G
T
0.086106
0.011742
0.076321
0.019569
0.017613
0.013699
0.005871
0.013699
0.080235
0.013699
0.078278
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0.021526
0.023483
0.015656
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0.064579
0.084149
0.015656
0.021526
0.037182
0.086106
0.005871
0.007828
0.011742
0
31,047
G
G
G
C
C
C
A
T
C
T
T
C
G
A
G
C
A
T
C
T
G
C
T
C
T
C
C
G
G
C
A
A
T
G
T
G
G
C
C
A
T
T
G
T
T
C
T
C
C
A
T
C
C
A
G
A
A
G
G
C
C
C
T
C
T
C
0.043053
0.017613
0.060665
0.017613
0.02544
0.021526
0.007828
0.013699
0.056751
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0.060665
0.052838
0.017613
0.033268
0.056751
0.068493
0.009785
0.009785
0.015656
0
31,048
T
A
G
C
C
C
A
A
G
G
C
A
T
T
C
A
A
C
T
T
A
C
A
G
G
A
A
A
G
T
A
T
C
T
C
T
G
A
A
C
A
A
C
A
C
C
A
A
A
A
T
C
G
A
T
A
A
A
A
C
C
G
A
T
T
T
0.076321
0.031311
0.039139
0.07045
0.041096
0.033268
0.003914
0.023483
0.046967
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0
0.02544
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0.017613
0.019569
0.011742
0.023483
0.023483
0.062622
0.043053
0
31,049
A
A
G
T
T
T
T
A
A
C
G
G
G
C
T
C
A
A
G
C
A
G
A
T
C
T
G
C
A
A
G
G
C
C
C
A
G
C
T
T
T
T
C
T
C
C
T
G
A
T
C
C
T
T
C
A
G
A
A
C
T
G
A
C
A
A
0.072407
0.029354
0.050881
0.033268
0.017613
0.02544
0.001957
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0
0.001957
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0.060665
0.015656
0.029354
0.027397
0.039139
0.009785
0.013699
0.056751
0
31,050
T
G
A
T
T
T
G
A
C
T
C
T
A
T
T
C
A
G
T
T
G
C
T
T
T
T
T
T
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C
A
G
T
G
G
C
C
A
A
A
G
A
A
G
A
T
G
A
A
G
T
T
T
T
A
A
C
G
G
G
C
T
C
A
A
C
0.07045
0.029354
0.052838
0.029354
0.017613
0.019569
0.001957
0.037182
0.054795
0.04501
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0
0.005871
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0.060665
0.015656
0.031311
0.027397
0.046967
0.009785
0.013699
0.054795
0
31,051
T
G
T
T
C
T
T
G
G
C
C
A
A
C
T
G
T
T
C
C
T
G
C
A
T
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C
T
T
G
G
C
G
A
G
C
C
T
C
C
A
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G
T
C
A
T
A
T
T
T
G
G
C
C
A
T
A
A
T
T
G
C
C
T
0.064579
0.02544
0.060665
0.029354
0.031311
0.017613
0.003914
0.035225
0.043053
0.039139
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0.058708
0.017613
0.039139
0.043053
0.04501
0.011742
0.015656
0.041096
0
31,052
C
T
G
T
C
A
G
A
C
C
T
C
A
T
T
G
G
A
G
C
T
T
C
A
G
T
T
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A
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T
A
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G
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T
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A
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A
C
T
A
C
A
C
A
A
G
A
T
A
A
T
A
A
G
G
A
C
0.082192
0.033268
0.046967
0.064579
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0.029354
0.029354
0.015656
0
0.003914
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0.037182
0.052838
0.013699
0.015656
0.009785
0.023483
0.02544
0.058708
0.043053
0
31,053
T
T
T
G
G
G
A
A
T
A
A
G
A
T
T
C
T
C
T
A
A
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T
A
T
G
G
A
T
G
G
T
C
G
G
T
C
T
C
G
A
G
G
0.084149
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0.041096
0.027397
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0.029354
0.029354
0.011742
0.031311
0.021526
0.039139
0.04501
0
31,054
T
C
G
T
A
C
T
T
A
T
C
C
A
T
G
G
T
C
T
C
C
A
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G
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G
T
T
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C
C
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A
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G
A
G
T
A
A
T
G
T
A
A
A
T
T
T
A
T
C
A
C
G
0.105675
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0
0.017613
0.023483
0.039139
0.02544
0.013699
0.02544
0.021526
0.019569
0.068493
0.04501
0
31,055
C
A
G
C
C
T
T
G
C
C
A
A
G
A
C
A
G
A
G
A
C
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C
T
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C
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A
T
A
A
C
T
G
A
A
A
T
G
A
G
A
C
A
G
A
G
C
0.076321
0.031311
0.060665
0.035225
0.043053
0.019569
0.007828
0.046967
0.041096
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0.039139
0.023483
0.027397
0.033268
0.037182
0.037182
0.02544
0.015656
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0.009785
0.001957
0.027397
0.02544
0.041096
0.027397
0.027397
0.02544
0.02544
0.021526
0.052838
0.039139
0
31,056
A
C
G
A
C
C
A
C
T
G
A
A
G
T
T
T
C
C
T
C
C
A
C
G
A
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C
A
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T
T
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C
A
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G
A
A
A
C
C
A
T
C
T
C
C
A
C
G
A
C
C
A
C
C
0.066536
0.019569
0.048924
0.046967
0.021526
0.048924
0.009785
0.029354
0.023483
0.029354
0.029354
0.017613
0.023483
0.037182
0.056751
0.048924
0.029354
0.09002
0.02544
0.007828
0.015656
0.001957
0.011742
0.021526
0.043053
0.02544
0.02544
0.041096
0.037182
0.015656
0.013699
0.037182
0
31,057
G
T
G
G
T
T
T
T
G
C
A
A
A
G
T
A
T
T
G
G
C
C
T
C
C
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C
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G
C
C
A
T
A
G
G
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C
C
A
G
A
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C
T
T
C
T
G
C
C
T
C
C
A
A
A
A
T
T
T
C
C
T
C
0.064579
0.023483
0.035225
0.041096
0.037182
0.043053
0.007828
0.023483
0.027397
0.050881
0.029354
0.019569
0.017613
0.035225
0.050881
0.050881
0.043053
0.088063
0.019569
0.003914
0.007828
0.003914
0.02544
0.027397
0.033268
0.017613
0.033268
0.041096
0.039139
0.019569
0.017613
0.021526
0
31,058
C
A
A
G
A
A
G
C
T
G
T
T
G
T
C
C
T
T
C
A
C
A
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G
A
T
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T
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C
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A
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A
A
G
A
G
A
A
T
T
T
T
C
T
T
C
A
T
A
T
T
T
0.068493
0.039139
0.050881
0.046967
0.054795
0.021526
0.005871
0.019569
0.048924
0.031311
0.048924
0.02544
0.02544
0.046967
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0.031311
0.037182
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0.005871
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0.043053
0.013699
0.039139
0.017613
0.029354
0.017613
0.056751
0.041096
0
31,059
G
C
C
T
G
G
C
T
C
T
C
G
G
C
T
C
G
G
G
G
T
G
T
C
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T
C
G
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A
A
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A
C
A
C
G
C
C
G
C
T
G
A
T
C
G
T
C
A
T
C
A
C
0.001957
0.013699
0.017613
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0.035225
0.02544
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0.009785
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0.019569
0.019569
0.011742
0.041096
0.04501
0.037182
0.082192
0.105675
0.035225
0.076321
0
0.04501
0.019569
0.021526
0.046967
0.103718
0.041096
0.003914
0.001957
0.019569
0
31,060
A
G
C
G
G
C
G
G
C
G
G
C
G
G
C
A
G
C
G
G
C
G
A
A
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G
G
T
G
A
G
G
T
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G
C
C
G
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C
G
C
G
C
C
T
G
G
G
G
C
G
G
C
C
A
G
C
G
G
G
G
T
G
A
C
0.003914
0.007828
0.013699
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0.009785
0.043053
0.029354
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0.013699
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0.043053
0.035225
0.064579
0.09589
0.033268
0.11546
0.013699
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0.009785
0.035225
0.048924
0.101761
0.031311
0.007828
0
0.021526
0
31,061
T
G
G
G
A
C
C
T
C
C
A
A
T
T
C
C
C
A
G
C
C
C
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G
C
T
T
C
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C
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C
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A
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G
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T
T
G
A
C
T
C
C
A
G
C
T
C
C
A
G
C
T
T
C
C
0.033268
0.015656
0.033268
0.035225
0.021526
0.023483
0.005871
0.015656
0.035225
0.068493
0.054795
0.009785
0.013699
0.031311
0.019569
0.02544
0.066536
0.062622
0.062622
0.019569
0.003914
0.005871
0.021526
0.052838
0.046967
0.015656
0.027397
0.054795
0.058708
0.009785
0.017613
0.031311
0
31,062
A
T
A
T
C
T
C
T
T
T
C
A
A
T
C
C
A
C
A
A
C
G
C
A
T
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A
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T
C
A
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C
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G
A
T
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T
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A
A
G
C
C
T
G
A
A
A
T
C
C
A
A
A
T
C
A
T
C
A
C
0.103718
0.04501
0.04501
0.078278
0.035225
0.013699
0.007828
0.037182
0.041096
0.017613
0.021526
0.060665
0.035225
0.027397
0.04501
0.015656
0.033268
0.021526
0.013699
0
0.007828
0.003914
0.017613
0.021526
0.04501
0.007828
0.021526
0.011742
0.017613
0.02544
0.078278
0.043053
0
31,063
G
G
G
C
G
T
C
T
A
C
A
T
C
G
T
C
C
C
A
G
G
A
G
C
A
G
C
A
C
C
A
G
C
T
A
C
A
G
G
A
A
C
C
T
G
C
C
G
G
T
A
A
G
G
G
T
T
A
G
G
G
T
C
A
A
A
0.027397
0.02544
0.046967
0.023483
0.019569
0.031311
0.009785
0.029354
0.029354
0.031311
0.054795
0.017613
0.019569
0.02544
0.027397
0.02544
0.043053
0.035225
0.062622
0.033268
0.019569
0.039139
0.013699
0.041096
0.048924
0.027397
0.037182
0.037182
0.054795
0.011742
0.019569
0.031311
0
31,064
T
T
C
A
G
A
G
A
G
A
A
T
A
T
C
T
C
A
A
G
T
A
A
G
G
G
A
G
T
G
T
G
C
C
C
T
G
T
A
A
G
A
G
G
T
A
A
T
T
A
T
A
C
A
T
A
A
C
T
T
C
A
G
T
C
T
0.103718
0.02544
0.027397
0.107632
0.052838
0.011742
0.001957
0.017613
0.033268
0.039139
0.019569
0.072407
0.017613
0.041096
0.039139
0.019569
0.033268
0.019569
0.007828
0.003914
0.001957
0.003914
0.027397
0.019569
0.035225
0.013699
0.023483
0.017613
0.013699
0.02544
0.086106
0.037182
0
31,065
A
C
T
T
G
A
T
T
T
T
A
C
G
A
A
A
A
A
C
A
C
T
G
G
A
T
T
A
A
A
T
A
T
G
C
A
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A
A
A
A
G
A
C
T
C
C
A
A
T
G
T
G
G
G
A
T
G
T
G
T
G
C
T
G
A
0.097847
0.041096
0.039139
0.07045
0.050881
0.011742
0.001957
0.039139
0.050881
0.005871
0.023483
0.039139
0.043053
0.048924
0.048924
0.021526
0.029354
0.021526
0.005871
0
0.003914
0.001957
0.02544
0.02544
0.048924
0.017613
0.023483
0.003914
0.029354
0.023483
0.052838
0.052838
0
31,066
C
G
C
C
G
C
G
G
C
C
G
C
C
G
C
C
G
C
C
G
C
C
C
C
A
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C
A
C
C
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C
T
G
C
T
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C
T
C
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C
C
A
T
G
G
C
T
A
A
G
G
C
C
G
A
G
G
G
A
G
G
C
G
C
0.013699
0.019569
0.02544
0.021526
0.005871
0.019569
0.027397
0.013699
0.02544
0.033268
0.058708
0.001957
0.019569
0.019569
0.027397
0.023483
0.037182
0.04501
0.054795
0.064579
0.023483
0.084149
0.011742
0.056751
0.033268
0.015656
0.035225
0.091977
0.054795
0.007828
0.005871
0.021526
0
31,067
A
C
T
C
T
T
T
C
T
G
G
T
G
C
C
C
C
T
C
T
C
T
T
C
C
A
C
A
C
C
T
A
C
T
C
C
C
T
G
A
C
T
G
C
T
C
C
C
A
T
T
C
A
C
C
A
G
G
G
G
C
G
A
G
C
T
0.035225
0.011742
0.046967
0.009785
0.017613
0.035225
0.015656
0.02544
0.037182
0.035225
0.066536
0.003914
0.009785
0.011742
0.027397
0.031311
0.04501
0.056751
0.082192
0.027397
0.015656
0.027397
0.015656
0.056751
0.035225
0.027397
0.029354
0.052838
0.062622
0.02544
0.005871
0.013699
0
31,068
A
A
A
T
G
A
A
G
A
A
G
A
T
G
T
G
G
A
G
A
A
A
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A
A
G
A
A
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A
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A
C
A
G
A
A
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G
A
A
T
G
G
T
A
T
G
A
A
T
C
T
A
A
G
C
A
G
G
A
T
T
T
T
G
0.097847
0.039139
0.04501
0.058708
0.060665
0.013699
0.009785
0.023483
0.064579
0.02544
0.009785
0.060665
0.029354
0.050881
0.033268
0.023483
0.035225
0.02544
0.015656
0
0.003914
0.001957
0.015656
0.023483
0.04501
0.017613
0.023483
0.007828
0.013699
0.027397
0.064579
0.033268
0
31,069
T
T
A
T
T
T
A
T
A
T
A
C
T
T
G
C
C
T
C
T
T
T
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C
A
T
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T
C
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C
C
A
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A
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T
C
C
A
T
A
C
T
G
T
A
G
C
T
T
C
C
A
A
G
C
0.117417
0.021526
0.052838
0.074364
0.035225
0.015656
0
0.037182
0.035225
0.027397
0.021526
0.088063
0.019569
0.04501
0.035225
0.019569
0.017613
0.017613
0.005871
0.001957
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0.007828
0.035225
0.015656
0.048924
0.005871
0.027397
0.011742
0.013699
0.041096
0.064579
0.037182
0
31,070
A
A
G
C
T
G
A
T
C
T
T
C
A
G
G
A
A
A
A
G
C
T
T
T
T
A
A
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A
A
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T
A
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T
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C
T
C
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T
C
T
G
T
C
A
A
C
T
C
A
A
A
G
T
C
A
C
G
C
A
C
0.103718
0.031311
0.046967
0.074364
0.031311
0.017613
0.003914
0.029354
0.056751
0.027397
0.017613
0.072407
0.039139
0.037182
0.043053
0.007828
0.031311
0.02544
0.001957
0
0.005871
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0.031311
0.021526
0.052838
0.019569
0.011742
0.005871
0.019569
0.021526
0.058708
0.050881
0
31,071
C
T
T
T
G
A
A
A
A
T
A
T
T
G
T
T
G
A
G
T
T
T
C
T
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A
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C
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G
A
A
T
A
C
C
T
C
T
G
A
A
A
T
G
G
A
A
A
T
0.127202
0.027397
0.037182
0.064579
0.035225
0.013699
0.007828
0.033268
0.043053
0.039139
0.017613
0.080235
0.023483
0.039139
0.033268
0.023483
0.033268
0.013699
0.007828
0
0
0.003914
0.043053
0.021526
0.043053
0.009785
0.035225
0.007828
0.009785
0.029354
0.050881
0.04501
0
31,072
C
T
T
T
T
C
T
G
G
G
T
C
A
T
C
C
T
C
C
C
C
A
G
A
C
A
G
G
A
A
T
A
C
A
A
C
C
A
G
C
G
G
T
T
C
C
T
C
C
T
C
C
A
T
G
G
T
T
G
G
A
G
A
G
A
T
0.064579
0.037182
0.048924
0.041096
0.043053
0.023483
0.001957
0.039139
0.060665
0.031311
0.029354
0.023483
0.02544
0.035225
0.027397
0.02544
0.048924
0.037182
0.029354
0.005871
0.005871
0.005871
0.029354
0.033268
0.062622
0.017613
0.02544
0.007828
0.041096
0.027397
0.033268
0.031311
0
31,073
C
C
T
G
C
G
T
T
G
C
G
T
C
C
C
C
G
C
G
C
C
G
G
G
C
G
C
T
G
G
G
G
C
C
T
C
G
G
G
G
G
G
C
A
C
T
A
G
T
C
C
G
T
C
G
G
C
C
A
C
G
C
A
G
C
T
0.005871
0.011742
0.023483
0.001957
0.013699
0.027397
0.02544
0.007828
0.017613
0.054795
0.04501
0.009785
0.02544
0.013699
0.019569
0.027397
0.056751
0.043053
0.088063
0.072407
0.037182
0.080235
0.009785
0.037182
0.015656
0.02544
0.041096
0.101761
0.029354
0.009785
0.001957
0.019569
0
31,074
T
G
G
C
C
T
G
T
T
G
A
G
G
C
C
A
A
G
T
A
G
G
G
G
C
A
C
T
G
G
A
A
T
T
A
G
G
A
T
G
C
C
T
G
G
G
T
T
T
A
A
A
G
C
C
C
T
G
C
T
C
T
G
C
C
C
0.080235
0.033268
0.039139
0.058708
0.037182
0.029354
0
0.035225
0.035225
0.037182
0.037182
0.041096
0.023483
0.04501
0.037182
0.023483
0.033268
0.029354
0.021526
0
0.003914
0
0.041096
0.031311
0.023483
0.013699
0.035225
0.021526
0.015656
0.031311
0.07045
0.035225
0
31,075
C
T
C
C
A
G
A
A
A
T
T
C
A
A
G
C
A
A
A
A
T
T
T
C
T
C
T
G
T
G
T
A
C
T
T
G
A
A
A
G
G
A
C
A
T
G
C
C
C
A
T
C
C
A
A
A
G
A
A
A
A
A
A
G
T
T
0.056751
0.019569
0.056751
0.029354
0.033268
0.015656
0.005871
0.037182
0.068493
0.02544
0.031311
0.027397
0.033268
0.029354
0.023483
0.027397
0.054795
0.037182
0.033268
0.019569
0.011742
0.005871
0.017613
0.035225
0.068493
0.021526
0.027397
0.031311
0.041096
0.023483
0.013699
0.037182
0