Datasets:
TabBioMed
/
vep_pathogenic_coding

Dataset card Data Studio Files
xet
 Community
row_idx
int64
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
31,076
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T
G
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G
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31,079
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A
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31,080
G
G
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C
T
T
C
A
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A
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A
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C
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A
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G
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G
G
G
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C
T
A
C
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G
C
G
G
A
A
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C
C
C
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C
C
T
C
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G
T
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C
T
C
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A
A
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A
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C
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A
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31,082
A
A
T
A
T
T
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A
A
A
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A
A
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A
A
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A
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31,083
A
A
A
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A
T
T
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G
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G
G
G
A
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A
A
A
T
A
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G
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G
C
C
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A
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31,084
C
A
A
A
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G
G
G
A
G
G
G
G
G
G
A
G
C
T
T
T
A
A
A
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T
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31,085
A
A
A
T
C
A
C
A
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C
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C
T
C
T
T
A
C
C
C
A
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C
A
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T
T
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G
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A
A
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T
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C
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31,086
A
A
A
A
C
T
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T
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G
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A
C
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A
C
T
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A
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31,087
C
T
G
G
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C
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C
C
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T
G
G
G
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C
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A
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C
A
G
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C
A
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31,088
T
C
C
A
A
A
C
A
T
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A
T
G
G
A
G
T
T
G
C
G
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G
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G
G
C
A
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G
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C
A
G
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G
G
A
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A
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A
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A
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T
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31,090
T
T
C
A
A
A
C
C
C
A
G
C
A
C
C
G
C
A
G
A
T
T
G
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G
C
A
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G
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G
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C
T
T
C
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C
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C
C
A
G
C
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C
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T
G
A
A
A
C
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G
A
C
T
C
T
T
T
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31,091
A
G
C
A
C
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C
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A
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T
C
T
T
C
T
G
C
A
C
G
A
G
C
C
C
C
T
C
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G
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C
C
A
G
A
T
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C
A
T
A
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31,092
T
G
G
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C
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T
T
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T
G
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A
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G
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A
G
G
T
T
C
A
T
A
A
A
C
G
A
T
C
C
T
T
C
T
C
0.068493
0.041096
0.052838
0.060665
0.027397
0.031311
0.005871
0.035225
0.037182
0.013699
0.046967
0.04501
0.035225
0.031311
0.041096
0.013699
0.027397
0.033268
0.015656
0.003914
0.005871
0.007828
0.031311
0.021526
0.048924
0.015656
0.019569
0.009785
0.043053
0.029354
0.064579
0.035225
0
31,093
G
C
A
T
T
C
C
T
C
C
T
C
G
T
T
G
G
A
C
G
T
G
C
C
C
G
C
T
G
T
C
A
C
G
C
T
C
T
C
G
T
C
C
T
T
G
C
A
G
A
T
A
G
T
G
T
A
G
G
G
T
A
A
T
G
T
0.043053
0.031311
0.04501
0.015656
0.043053
0.033268
0.019569
0.029354
0.04501
0.041096
0.050881
0.017613
0.015656
0.02544
0.035225
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0.054795
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0.035225
0.007828
0.009785
0.009785
0.013699
0.050881
0.02544
0.029354
0.054795
0.023483
0.033268
0.015656
0.031311
0.033268
0
31,094
C
A
C
A
A
C
A
A
A
G
G
A
A
A
A
A
A
A
C
C
T
G
A
G
T
A
G
A
G
C
C
T
C
C
C
A
G
G
C
T
C
A
T
G
G
T
T
A
C
C
A
G
C
A
C
A
T
G
C
A
G
G
G
A
A
T
0.064579
0.031311
0.035225
0.039139
0.039139
0.027397
0.001957
0.027397
0.046967
0.037182
0.039139
0.009785
0.017613
0.035225
0.029354
0.035225
0.056751
0.048924
0.060665
0.005871
0.003914
0.007828
0.02544
0.033268
0.058708
0.015656
0.031311
0.033268
0.033268
0.013699
0.017613
0.037182
0
31,095
C
A
A
G
G
C
A
C
C
T
T
C
T
G
C
A
T
A
A
C
T
C
C
C
T
C
C
T
A
C
C
T
C
T
T
C
T
C
A
T
T
G
G
A
C
T
G
T
G
T
G
T
G
T
T
C
A
C
A
T
G
T
T
C
A
T
0.082192
0.033268
0.04501
0.04501
0.056751
0.023483
0.005871
0.027397
0.043053
0.021526
0.033268
0.033268
0.023483
0.039139
0.058708
0.035225
0.041096
0.039139
0.02544
0.003914
0.001957
0
0.015656
0.02544
0.039139
0.02544
0.037182
0.027397
0.02544
0.019569
0.02544
0.041096
0
31,096
A
G
G
G
A
A
G
C
G
A
A
A
T
C
G
A
G
G
A
C
A
C
T
G
A
T
G
A
T
T
C
T
C
C
C
A
A
G
C
C
C
G
C
A
G
G
T
G
A
G
C
T
G
T
T
A
C
C
T
T
G
G
A
A
A
T
0.043053
0.033268
0.031311
0.021526
0.043053
0.029354
0.017613
0.029354
0.023483
0.033268
0.056751
0.023483
0.02544
0.019569
0.023483
0.043053
0.046967
0.033268
0.048924
0.02544
0.019569
0.019569
0.019569
0.04501
0.035225
0.021526
0.033268
0.023483
0.060665
0.021526
0.02544
0.023483
0
31,097
G
C
T
G
C
T
C
A
C
C
A
A
G
C
A
G
G
C
G
G
G
G
G
A
G
A
T
C
A
A
G
A
C
G
C
T
C
A
A
G
G
A
A
G
A
G
T
G
C
A
A
A
C
G
C
C
G
G
A
A
G
A
A
G
A
T
0.02544
0.02544
0.043053
0.019569
0.031311
0.027397
0.015656
0.033268
0.039139
0.054795
0.02544
0.02544
0.035225
0.029354
0.031311
0.046967
0.064579
0.039139
0.02544
0.019569
0.019569
0.023483
0.003914
0.043053
0.035225
0.021526
0.052838
0.029354
0.027397
0.015656
0.021526
0.048924
0
31,098
G
A
A
T
G
T
T
T
T
A
A
T
T
T
T
A
T
C
T
C
C
A
G
A
G
T
A
A
A
T
A
G
C
T
G
T
A
G
C
A
A
T
T
T
C
T
T
C
C
T
T
T
G
C
C
A
G
T
T
G
C
C
C
A
A
T
0.117417
0.035225
0.035225
0.078278
0.050881
0.009785
0
0.029354
0.04501
0.021526
0.015656
0.078278
0.029354
0.048924
0.037182
0.017613
0.031311
0.021526
0.009785
0.001957
0.001957
0
0.02544
0.019569
0.052838
0.007828
0.021526
0.007828
0.021526
0.029354
0.058708
0.039139
0
31,099
A
G
G
C
T
T
C
G
C
C
G
A
G
C
G
G
G
T
G
G
A
C
C
T
G
T
A
C
A
C
C
A
C
G
T
C
G
A
G
G
C
T
C
T
C
A
G
G
C
G
C
C
G
C
C
T
C
C
T
C
G
C
C
C
C
T
0.009785
0.001957
0.029354
0.001957
0.023483
0.041096
0.021526
0.009785
0.019569
0.050881
0.07045
0.003914
0.007828
0.019569
0.009785
0.041096
0.058708
0.048924
0.072407
0.052838
0.039139
0.039139
0.003914
0.058708
0.023483
0.037182
0.039139
0.078278
0.052838
0.015656
0
0.017613
0
31,100
G
A
T
G
G
T
G
T
C
C
T
C
A
T
C
C
T
C
C
T
T
C
C
T
C
A
A
A
G
C
C
A
C
C
G
G
C
T
C
C
T
C
C
T
G
G
A
C
G
G
G
T
T
G
G
G
T
A
C
T
G
A
G
A
T
T
0.074364
0.029354
0.050881
0.048924
0.041096
0.023483
0.001957
0.037182
0.04501
0.033268
0.029354
0.04501
0.02544
0.033268
0.050881
0.02544
0.033268
0.043053
0.013699
0.007828
0
0.005871
0.013699
0.046967
0.037182
0.019569
0.011742
0.019569
0.037182
0.029354
0.039139
0.046967
0
31,101
G
A
T
G
T
C
T
G
C
T
G
A
A
T
C
G
T
C
A
T
C
A
A
G
G
A
A
T
T
C
T
C
C
G
G
A
A
G
G
A
G
G
C
C
G
G
G
A
G
G
A
C
T
T
C
G
C
A
G
A
G
T
G
C
G
T
0.017613
0.013699
0.031311
0.02544
0.02544
0.023483
0.011742
0.02544
0.046967
0.041096
0.039139
0.02544
0.027397
0.039139
0.027397
0.015656
0.048924
0.037182
0.064579
0.041096
0.021526
0.015656
0.017613
0.054795
0.039139
0.04501
0.027397
0.033268
0.060665
0.011742
0.003914
0.041096
0
31,102
A
A
A
A
G
G
T
T
C
A
A
A
T
G
T
A
A
G
T
C
C
C
T
C
C
G
A
T
G
C
C
T
C
C
T
T
T
C
T
G
C
T
C
C
C
C
G
C
G
C
A
G
T
G
C
A
T
A
G
T
G
A
G
G
C
T
0.064579
0.019569
0.052838
0.033268
0.035225
0.023483
0.013699
0.017613
0.052838
0.041096
0.039139
0.017613
0.037182
0.02544
0.039139
0.033268
0.048924
0.029354
0.033268
0.019569
0.011742
0.013699
0.009785
0.039139
0.048924
0.021526
0.04501
0.017613
0.046967
0.015656
0.017613
0.035225
0
31,103
C
G
G
T
C
C
C
A
C
C
A
G
C
C
T
G
G
C
T
C
C
T
T
T
T
C
C
C
T
T
A
T
T
A
G
G
A
C
T
C
C
A
C
A
C
T
T
A
G
G
A
C
A
A
G
C
C
A
G
G
C
G
C
A
T
G
0.033268
0.017613
0.043053
0.019569
0.031311
0.035225
0.011742
0.019569
0.037182
0.041096
0.056751
0.015656
0.037182
0.02544
0.023483
0.050881
0.050881
0.052838
0.037182
0.017613
0.009785
0.027397
0.017613
0.043053
0.035225
0.015656
0.033268
0.043053
0.050881
0.013699
0.019569
0.033268
0
31,104
C
G
T
T
T
G
G
A
G
G
C
A
G
T
G
G
A
T
G
T
G
T
G
C
T
G
G
G
A
A
G
C
C
G
C
T
C
T
G
T
G
T
G
A
C
C
T
G
A
G
G
G
T
G
A
T
T
T
G
T
C
A
C
T
G
T
0.029354
0.019569
0.031311
0.009785
0.054795
0.029354
0.009785
0.035225
0.021526
0.037182
0.064579
0.007828
0.019569
0.02544
0.033268
0.060665
0.076321
0.052838
0.066536
0.001957
0
0.007828
0.013699
0.037182
0.023483
0.037182
0.039139
0.041096
0.048924
0.013699
0.003914
0.046967
0
31,105
C
C
A
G
G
G
C
C
T
G
C
A
G
C
T
C
C
G
G
A
A
G
A
G
T
G
T
T
G
G
G
G
C
G
A
G
G
G
G
A
G
C
G
C
G
G
A
G
G
A
C
T
A
G
G
C
G
C
C
C
G
C
A
C
C
T
0
0.007828
0.009785
0
0.009785
0.031311
0.02544
0.019569
0.007828
0.029354
0.052838
0.001957
0.007828
0.005871
0.009785
0.033268
0.037182
0.041096
0.129159
0.113503
0.019569
0.080235
0.009785
0.054795
0.007828
0.037182
0.029354
0.099804
0.074364
0.007828
0
0.005871
0
31,106
A
G
T
G
A
G
C
A
C
C
A
A
C
T
C
A
C
A
C
G
T
G
C
A
C
A
G
G
A
A
G
G
C
T
G
T
C
G
G
G
G
G
T
G
C
C
A
T
C
A
T
G
G
T
T
G
T
G
G
T
C
T
G
T
G
T
0.035225
0.023483
0.046967
0.035225
0.046967
0.029354
0.005871
0.033268
0.037182
0.039139
0.041096
0.013699
0.021526
0.039139
0.048924
0.050881
0.037182
0.043053
0.037182
0.003914
0.007828
0.009785
0.011742
0.054795
0.027397
0.033268
0.035225
0.021526
0.037182
0.007828
0.029354
0.054795
0
31,107
T
C
C
C
C
G
C
C
T
C
G
G
C
G
G
A
G
A
C
T
C
G
G
A
A
G
T
T
C
A
C
C
C
G
G
G
C
G
C
T
G
A
G
T
A
A
G
C
C
G
G
G
C
A
C
G
G
C
G
G
C
C
G
A
G
T
0
0.003914
0.013699
0.001957
0.007828
0.021526
0.011742
0.013699
0.019569
0.043053
0.048924
0
0.005871
0.003914
0.005871
0.02544
0.046967
0.017613
0.09589
0.133072
0.019569
0.121331
0.001957
0.060665
0.009785
0.023483
0.043053
0.133072
0.046967
0.001957
0.003914
0.013699
0
31,108
T
C
C
A
T
C
T
C
G
A
A
A
G
T
C
A
A
T
G
T
A
C
A
C
C
A
G
A
T
C
T
A
T
G
G
C
T
T
G
G
A
G
A
C
C
A
A
A
G
G
C
T
T
T
C
G
C
T
A
T
G
A
C
A
A
C
0.078278
0.02544
0.043053
0.048924
0.039139
0.023483
0.007828
0.02544
0.048924
0.029354
0.029354
0.043053
0.027397
0.033268
0.041096
0.023483
0.037182
0.041096
0.027397
0.011742
0.009785
0.013699
0.023483
0.031311
0.043053
0.02544
0.023483
0.023483
0.035225
0.021526
0.033268
0.031311
0
31,109
C
C
A
A
C
T
A
C
C
G
A
A
C
T
T
G
T
G
T
C
C
T
T
C
T
A
T
T
C
A
G
G
T
A
G
G
T
C
G
G
T
A
T
T
G
C
T
G
C
T
C
T
T
G
G
C
T
T
T
G
C
A
T
T
C
C
0.035225
0.013699
0.033268
0.019569
0.046967
0.041096
0.005871
0.02544
0.033268
0.041096
0.062622
0.015656
0.023483
0.02544
0.029354
0.048924
0.072407
0.046967
0.054795
0.007828
0.003914
0.005871
0.017613
0.039139
0.02544
0.027397
0.041096
0.037182
0.037182
0.029354
0.011742
0.041096
0
31,110
C
A
A
C
A
G
A
A
G
C
A
A
T
G
C
A
A
G
A
C
A
G
A
A
T
G
C
A
G
A
A
A
T
A
G
A
C
A
G
A
G
G
T
G
G
C
C
A
T
G
G
A
C
A
G
A
G
C
C
T
T
A
G
G
A
C
0.054795
0.033268
0.037182
0.056751
0.041096
0.021526
0.011742
0.029354
0.048924
0.031311
0.031311
0.046967
0.017613
0.039139
0.033268
0.027397
0.048924
0.041096
0.02544
0.005871
0.001957
0.003914
0.02544
0.027397
0.056751
0.015656
0.031311
0.023483
0.033268
0.027397
0.037182
0.033268
0
31,111
T
A
T
T
T
A
C
A
T
T
T
A
T
T
G
G
A
G
A
T
T
T
A
A
A
A
T
A
A
A
A
G
T
G
T
T
A
C
A
A
A
T
C
C
A
A
A
A
G
A
G
C
T
T
G
T
A
C
A
A
A
C
C
G
A
C
0.111546
0.021526
0.054795
0.058708
0.023483
0.017613
0
0.035225
0.043053
0.037182
0.031311
0.027397
0.023483
0.023483
0.041096
0.02544
0.041096
0.043053
0.019569
0.009785
0.005871
0.003914
0.013699
0.037182
0.046967
0.009785
0.029354
0.031311
0.033268
0.019569
0.04501
0.035225
0
31,112
G
A
A
T
C
C
A
A
A
A
G
T
C
A
G
C
A
G
C
A
C
A
C
A
G
T
A
C
C
C
A
A
C
G
C
T
G
G
G
G
A
G
G
T
A
G
A
G
G
A
C
A
C
G
C
T
C
T
G
C
G
A
C
C
A
T
0.058708
0.027397
0.039139
0.035225
0.035225
0.021526
0.011742
0.031311
0.048924
0.039139
0.023483
0.021526
0.037182
0.041096
0.02544
0.033268
0.050881
0.043053
0.021526
0.015656
0.015656
0.023483
0.007828
0.043053
0.046967
0.019569
0.029354
0.021526
0.039139
0.019569
0.029354
0.043053
0
31,113
C
A
T
C
T
T
A
C
T
G
T
T
A
T
A
T
T
G
T
A
G
G
T
A
C
C
A
A
A
T
C
A
T
T
G
A
T
G
A
C
A
A
G
C
A
T
C
G
T
T
G
A
T
G
A
G
G
T
T
C
A
T
A
G
T
C
0.052838
0.021526
0.048924
0.048924
0.043053
0.033268
0.003914
0.029354
0.052838
0.037182
0.031311
0.031311
0.033268
0.046967
0.039139
0.027397
0.037182
0.037182
0.027397
0
0.003914
0
0.023483
0.041096
0.027397
0.021526
0.021526
0.017613
0.017613
0.039139
0.054795
0.048924
0
31,114
T
A
A
C
A
A
T
T
T
T
C
A
C
A
G
G
G
T
A
T
A
C
T
T
C
T
T
A
C
C
T
G
C
A
T
T
A
G
A
G
C
A
G
A
T
G
A
T
G
T
C
T
T
G
T
G
A
A
T
T
C
T
T
G
C
A
0.074364
0.035225
0.041096
0.056751
0.050881
0.019569
0.001957
0.048924
0.041096
0.019569
0.013699
0.031311
0.029354
0.041096
0.056751
0.041096
0.041096
0.046967
0.021526
0
0
0.001957
0.019569
0.021526
0.041096
0.021526
0.033268
0.015656
0.02544
0.023483
0.035225
0.048924
0
31,115
A
G
A
A
A
A
G
T
G
C
A
T
G
A
G
G
A
G
T
T
T
G
C
C
T
T
T
T
T
C
T
T
T
T
A
C
T
G
A
G
T
G
G
T
T
T
T
G
G
A
G
G
G
T
A
T
G
A
G
G
C
A
A
T
A
C
0.084149
0.039139
0.041096
0.046967
0.046967
0.021526
0.003914
0.033268
0.066536
0.019569
0.031311
0.037182
0.031311
0.041096
0.046967
0.02544
0.035225
0.02544
0.011742
0
0.003914
0
0.029354
0.043053
0.052838
0.019569
0.02544
0.009785
0.02544
0.023483
0.027397
0.050881
0
31,116
C
A
T
T
T
T
A
T
T
C
A
T
A
T
G
T
T
C
C
T
C
T
T
T
C
T
C
C
C
A
A
A
C
G
T
A
A
A
G
A
T
C
A
G
A
A
A
G
G
C
A
G
A
T
T
A
A
C
A
A
T
A
A
G
A
T
0.07045
0.02544
0.050881
0.060665
0.029354
0.013699
0.011742
0.027397
0.078278
0.019569
0.021526
0.037182
0.041096
0.04501
0.033268
0.029354
0.029354
0.02544
0.013699
0.005871
0.001957
0.007828
0.029354
0.037182
0.064579
0.013699
0.035225
0.011742
0.027397
0.013699
0.041096
0.046967
0
31,117
T
C
G
T
C
C
T
G
G
T
C
T
T
G
T
G
C
C
C
A
T
G
T
T
C
A
C
A
C
C
G
T
C
G
G
A
T
C
A
C
T
T
G
C
T
T
T
T
T
C
A
T
G
A
C
A
A
T
A
T
C
T
T
G
T
T
0.07045
0.031311
0.058708
0.033268
0.048924
0.021526
0.007828
0.02544
0.052838
0.023483
0.033268
0.031311
0.039139
0.037182
0.043053
0.033268
0.039139
0.033268
0.029354
0.007828
0.013699
0.005871
0.015656
0.019569
0.068493
0.023483
0.031311
0.009785
0.04501
0.015656
0.011742
0.039139
0
31,118
C
C
T
C
A
A
A
T
G
T
A
T
C
C
T
T
T
T
G
G
G
G
A
G
T
A
T
T
C
T
A
C
C
T
T
C
C
C
T
G
C
C
T
T
C
T
A
T
T
T
T
T
A
C
T
C
T
G
T
C
C
T
T
T
G
T
0.076321
0.017613
0.056751
0.04501
0.033268
0.019569
0.003914
0.031311
0.048924
0.021526
0.064579
0.027397
0.015656
0.039139
0.039139
0.031311
0.033268
0.02544
0.015656
0.001957
0.001957
0
0.023483
0.050881
0.062622
0.017613
0.046967
0.013699
0.058708
0.021526
0.017613
0.037182
0
31,119
T
C
C
T
T
T
C
A
A
A
G
T
G
A
T
A
C
A
T
T
T
G
A
G
G
C
C
C
A
T
T
A
C
A
T
C
T
T
T
C
A
C
A
T
C
T
A
C
T
A
T
A
T
T
T
T
C
T
C
T
A
T
C
T
T
T
0.086106
0.02544
0.058708
0.052838
0.041096
0.011742
0.003914
0.041096
0.074364
0.013699
0.027397
0.035225
0.037182
0.043053
0.029354
0.027397
0.033268
0.023483
0.003914
0.001957
0
0.001957
0.033268
0.031311
0.066536
0.013699
0.023483
0.011742
0.029354
0.031311
0.041096
0.04501
0
31,120
A
C
A
T
T
A
C
T
T
G
A
G
A
T
C
A
C
C
C
C
A
T
C
A
A
T
T
G
T
T
T
C
T
T
T
A
T
T
C
A
A
T
T
T
G
A
A
G
T
G
A
G
G
T
A
A
A
G
A
A
A
G
A
A
T
A
0.086106
0.031311
0.056751
0.052838
0.054795
0.015656
0.003914
0.043053
0.041096
0.011742
0.027397
0.056751
0.027397
0.046967
0.050881
0.033268
0.02544
0.019569
0.009785
0
0.003914
0.003914
0.021526
0.019569
0.056751
0.021526
0.023483
0.011742
0.019569
0.031311
0.033268
0.058708
0
31,121
A
A
A
T
C
A
A
A
G
A
C
C
T
G
T
A
C
C
C
C
A
T
C
T
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A
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G
A
T
T
T
C
A
T
T
C
C
T
T
T
T
G
G
A
A
A
T
A
A
G
A
G
A
C
T
T
G
C
A
T
A
T
T
T
A
0.086106
0.021526
0.068493
0.050881
0.031311
0.013699
0.003914
0.027397
0.056751
0.017613
0.04501
0.050881
0.039139
0.041096
0.041096
0.013699
0.029354
0.021526
0.011742
0.003914
0.003914
0.003914
0.033268
0.015656
0.054795
0.019569
0.041096
0.019569
0.037182
0.021526
0.043053
0.031311
0
31,122
C
G
G
A
C
A
C
C
A
G
G
A
C
T
A
G
A
C
T
T
G
T
T
T
T
C
T
G
C
A
G
A
T
C
A
G
C
T
A
A
G
C
A
C
T
A
T
A
A
C
T
A
A
G
A
A
T
A
G
A
C
T
A
G
A
A
0.09589
0.023483
0.058708
0.046967
0.031311
0.017613
0
0.035225
0.050881
0.019569
0.039139
0.052838
0.039139
0.037182
0.054795
0.011742
0.031311
0.027397
0.015656
0.003914
0
0
0.029354
0.023483
0.039139
0.023483
0.035225
0.019569
0.033268
0.02544
0.037182
0.041096
0
31,123
T
T
T
T
A
C
A
G
A
G
T
T
G
G
A
T
A
C
T
T
C
T
C
A
A
C
A
G
A
A
G
A
C
T
T
G
C
C
A
G
G
A
G
C
A
A
G
A
A
T
T
G
C
T
G
A
A
A
C
A
A
G
A
A
G
T
0.072407
0.039139
0.048924
0.064579
0.050881
0.013699
0.005871
0.031311
0.058708
0.007828
0.035225
0.041096
0.02544
0.029354
0.050881
0.021526
0.035225
0.029354
0.019569
0.003914
0.009785
0
0.023483
0.02544
0.072407
0.013699
0.027397
0.015656
0.039139
0.027397
0.029354
0.031311
0
31,124
T
G
C
A
G
T
A
C
C
A
T
A
C
T
C
A
A
G
C
A
G
C
T
G
G
G
A
A
A
C
T
G
T
T
A
T
T
C
T
T
T
T
T
G
C
C
T
T
C
A
A
T
T
T
T
A
T
C
T
G
T
T
T
G
G
G
0.09589
0.027397
0.058708
0.035225
0.050881
0.009785
0
0.037182
0.062622
0.039139
0.023483
0.029354
0.029354
0.039139
0.037182
0.017613
0.058708
0.035225
0.009785
0
0.003914
0
0.021526
0.02544
0.043053
0.023483
0.046967
0.015656
0.033268
0.029354
0.041096
0.019569
0
31,125
T
T
G
T
A
A
G
T
T
T
T
T
T
T
G
A
T
T
C
C
A
T
G
C
A
G
T
T
T
T
C
T
C
A
G
A
A
A
T
A
G
A
A
C
T
A
T
C
C
C
A
T
T
T
C
C
T
T
C
T
A
G
G
A
T
G
0.111546
0.039139
0.058708
0.041096
0.041096
0.013699
0.007828
0.033268
0.054795
0.017613
0.027397
0.04501
0.031311
0.043053
0.04501
0.017613
0.023483
0.023483
0.017613
0.007828
0.003914
0
0.029354
0.021526
0.062622
0.015656
0.029354
0.011742
0.033268
0.023483
0.031311
0.037182
0
31,126
G
T
T
T
T
G
A
A
T
T
T
A
C
T
G
T
A
C
A
T
A
T
T
G
T
G
C
C
A
T
T
T
T
G
G
G
T
C
T
G
G
A
G
G
C
A
T
T
T
C
T
T
T
G
T
C
T
C
C
T
C
T
C
T
T
G
0.076321
0.039139
0.052838
0.048924
0.052838
0.02544
0.009785
0.031311
0.046967
0.013699
0.043053
0.013699
0.017613
0.033268
0.046967
0.033268
0.046967
0.039139
0.023483
0.001957
0
0
0.009785
0.02544
0.058708
0.019569
0.031311
0.017613
0.041096
0.027397
0.035225
0.037182
0
31,127
T
T
T
G
T
T
T
C
T
G
A
T
A
A
T
T
T
T
T
T
T
T
T
A
A
T
T
T
C
C
T
G
C
C
T
T
T
T
A
A
A
A
T
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T
G
G
T
A
A
A
G
T
A
A
G
C
A
A
G
T
G
G
T
T
A
0.099804
0.02544
0.046967
0.064579
0.037182
0.023483
0.001957
0.037182
0.048924
0.015656
0.02544
0.062622
0.023483
0.029354
0.04501
0.023483
0.041096
0.033268
0.013699
0.005871
0
0
0.017613
0.021526
0.039139
0.015656
0.04501
0.017613
0.023483
0.035225
0.052838
0.027397
0
31,128
C
A
G
A
G
A
G
A
G
T
G
C
C
G
G
A
G
A
T
C
C
A
A
A
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A
A
T
C
C
A
C
T
T
A
C
A
A
T
G
C
C
A
G
A
G
A
A
C
T
T
G
C
C
A
G
T
T
G
G
T
G
A
A
C
C
0.093933
0.033268
0.058708
0.04501
0.041096
0.021526
0.001957
0.04501
0.050881
0.017613
0.021526
0.037182
0.027397
0.031311
0.056751
0.02544
0.037182
0.04501
0.017613
0.005871
0
0
0.017613
0.023483
0.04501
0.021526
0.031311
0.017613
0.033268
0.029354
0.033268
0.033268
0
31,129
G
G
A
G
T
T
G
T
C
A
A
A
T
G
T
C
G
G
T
T
T
G
C
T
C
A
T
T
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C
C
C
C
A
G
G
A
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C
A
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T
G
C
A
T
A
A
A
A
G
C
A
G
T
G
A
A
G
A
A
T
T
0.09589
0.04501
0.052838
0.048924
0.048924
0.021526
0.009785
0.041096
0.04501
0.013699
0.027397
0.031311
0.021526
0.041096
0.04501
0.029354
0.037182
0.031311
0.007828
0.001957
0.005871
0.001957
0.017613
0.019569
0.074364
0.011742
0.031311
0.003914
0.035225
0.033268
0.027397
0.041096
0
31,130
T
A
T
C
A
C
A
T
A
C
C
T
T
T
C
T
C
C
T
G
A
A
G
A
T
G
A
A
T
T
A
A
T
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A
C
T
G
A
C
C
A
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T
T
C
T
C
T
G
G
A
G
C
T
G
A
A
T
A
G
G
A
A
T
C
0.117417
0.033268
0.041096
0.09002
0.035225
0.013699
0.003914
0.027397
0.033268
0.02544
0.033268
0.060665
0.027397
0.02544
0.048924
0.011742
0.029354
0.013699
0.009785
0.003914
0.007828
0
0.02544
0.023483
0.064579
0.011742
0.011742
0.005871
0.031311
0.02544
0.052838
0.054795
0
31,131
T
T
T
T
T
T
T
T
C
C
A
T
T
A
A
A
A
T
A
G
A
C
G
G
A
A
G
A
C
A
G
T
T
G
C
C
C
C
A
A
A
A
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C
A
G
G
A
A
A
C
T
T
G
G
T
A
A
G
T
A
T
T
A
T
A
0.127202
0.02544
0.046967
0.09002
0.029354
0.017613
0.001957
0.029354
0.037182
0.019569
0.033268
0.056751
0.023483
0.02544
0.04501
0.015656
0.027397
0.021526
0.013699
0.003914
0.001957
0
0.021526
0.023483
0.068493
0.011742
0.011742
0.007828
0.035225
0.02544
0.048924
0.052838
0
31,132
G
G
A
T
T
T
G
G
C
C
A
C
A
T
G
T
T
G
C
C
C
T
T
G
G
A
A
T
T
T
A
A
T
T
T
C
C
A
C
C
T
T
C
A
G
A
T
T
T
T
T
G
T
A
G
C
T
T
G
C
A
T
A
C
A
C
0.119374
0.031311
0.048924
0.060665
0.035225
0.019569
0.003914
0.02544
0.04501
0.017613
0.027397
0.088063
0.02544
0.033268
0.039139
0.019569
0.029354
0.035225
0.013699
0.003914
0.005871
0.001957
0.013699
0.021526
0.056751
0.015656
0.017613
0.013699
0.033268
0.017613
0.04501
0.035225
0
31,133
T
T
G
T
A
C
A
T
T
C
A
T
T
A
A
A
G
A
T
G
A
A
C
T
T
T
C
A
G
C
A
T
C
T
T
C
A
C
T
T
G
A
A
G
A
T
C
C
A
T
C
A
G
A
T
G
A
T
T
C
T
G
A
G
A
G
0.076321
0.021526
0.072407
0.027397
0.021526
0.021526
0.009785
0.021526
0.076321
0.039139
0.037182
0.013699
0.035225
0.037182
0.021526
0.02544
0.043053
0.031311
0.017613
0.005871
0.013699
0.013699
0.019569
0.039139
0.080235
0.015656
0.031311
0.017613
0.035225
0.011742
0.021526
0.04501
0
31,134
C
C
C
T
T
C
T
G
T
C
A
T
C
T
T
T
A
G
G
T
A
C
A
T
C
T
C
T
G
G
T
T
T
C
T
C
T
C
G
T
T
G
T
T
C
C
T
G
T
T
T
C
C
A
T
T
G
G
A
A
T
G
T
T
T
G
0.058708
0.031311
0.043053
0.062622
0.07045
0.023483
0.001957
0.029354
0.056751
0.011742
0.02544
0.043053
0.029354
0.046967
0.033268
0.050881
0.039139
0.035225
0.017613
0
0.001957
0
0.013699
0.027397
0.058708
0.013699
0.017613
0.013699
0.023483
0.027397
0.04501
0.046967
0
31,135
G
A
G
A
G
T
T
T
T
C
A
G
A
T
T
T
G
C
T
C
A
G
A
A
G
A
A
T
G
C
T
C
C
T
T
T
G
A
A
A
A
C
C
T
A
T
G
A
A
G
T
A
G
A
T
T
T
T
A
C
C
C
A
A
T
T
0.123288
0.037182
0.046967
0.068493
0.033268
0.019569
0.007828
0.033268
0.060665
0.021526
0.013699
0.072407
0.027397
0.035225
0.037182
0.013699
0.029354
0.021526
0.003914
0
0.001957
0.001957
0.027397
0.02544
0.050881
0.009785
0.02544
0.001957
0.013699
0.033268
0.066536
0.035225
0
31,136
C
G
C
T
T
T
G
A
T
G
G
C
T
G
C
C
T
C
A
C
A
A
A
C
T
T
C
A
C
A
A
A
C
T
G
T
T
G
C
A
T
C
T
C
A
C
G
T
T
C
C
T
T
T
T
G
C
A
G
A
T
T
T
G
T
T
0.109589
0.039139
0.060665
0.062622
0.033268
0.007828
0.011742
0.033268
0.07045
0.02544
0.015656
0.035225
0.043053
0.039139
0.037182
0.019569
0.023483
0.013699
0.003914
0.001957
0.003914
0.001957
0.029354
0.031311
0.050881
0.009785
0.027397
0.007828
0.015656
0.017613
0.072407
0.04501
0
31,137
G
C
A
G
T
C
T
C
A
G
G
A
C
A
G
C
A
T
C
C
C
T
G
A
A
A
A
C
C
C
C
A
T
G
A
T
G
A
G
C
G
G
T
T
C
C
A
C
C
A
A
A
C
C
C
G
A
G
C
A
G
G
T
A
A
C
0.099804
0.037182
0.031311
0.078278
0.048924
0.02544
0.001957
0.031311
0.029354
0.023483
0.015656
0.052838
0.027397
0.041096
0.064579
0.019569
0.039139
0.02544
0.011742
0.005871
0.005871
0.005871
0.021526
0.007828
0.035225
0.023483
0.050881
0.001957
0.019569
0.027397
0.050881
0.039139
0
31,138
A
A
G
A
G
G
G
A
G
T
T
A
C
C
A
T
G
G
A
A
A
C
A
G
C
A
T
A
T
T
C
T
C
C
T
G
G
T
A
A
C
C
A
G
A
A
T
G
G
A
G
T
T
T
T
G
G
A
C
T
T
T
T
T
T
G
0.086106
0.021526
0.04501
0.050881
0.058708
0.019569
0.003914
0.041096
0.048924
0.009785
0.019569
0.084149
0.035225
0.04501
0.043053
0.041096
0.027397
0.031311
0.003914
0
0.001957
0.001957
0.02544
0.023483
0.041096
0.013699
0.033268
0.001957
0.029354
0.046967
0.031311
0.033268
0
31,139
G
C
T
C
G
G
C
C
C
C
G
C
T
T
T
C
C
C
C
G
C
G
T
T
C
A
C
C
G
G
G
G
C
G
G
G
C
T
C
C
G
G
C
G
G
G
A
A
G
G
C
C
A
A
G
T
G
C
G
C
G
C
A
G
G
A
0.005871
0.013699
0.029354
0.001957
0.011742
0.019569
0.021526
0.017613
0.017613
0.04501
0.054795
0.003914
0.003914
0.001957
0.019569
0.021526
0.050881
0.043053
0.129159
0.080235
0.019569
0.074364
0.003914
0.050881
0.02544
0.021526
0.023483
0.111546
0.048924
0.011742
0
0.015656
0
31,140
C
C
C
C
G
G
T
G
T
C
C
G
A
G
G
A
C
A
A
C
G
A
T
G
A
G
G
C
G
G
C
G
C
C
C
G
G
G
C
C
C
T
G
G
G
C
G
G
T
G
G
C
A
A
C
G
G
C
C
G
A
G
G
C
G
T
0.003914
0.009785
0.019569
0.001957
0.017613
0.033268
0.031311
0.009785
0.017613
0.037182
0.04501
0.003914
0.009785
0.015656
0.017613
0.027397
0.035225
0.039139
0.105675
0.101761
0.035225
0.068493
0.007828
0.046967
0.011742
0.04501
0.023483
0.105675
0.04501
0.009785
0.001957
0.015656
0
31,141
A
G
C
T
G
G
C
C
C
G
A
C
T
C
C
C
T
C
A
G
A
T
T
A
G
G
G
T
C
T
G
C
T
T
A
T
C
T
G
A
A
G
G
A
G
T
A
G
A
A
A
C
T
G
A
G
T
C
G
T
A
C
T
C
T
A
0.019569
0.019569
0.033268
0.019569
0.033268
0.027397
0.009785
0.035225
0.04501
0.041096
0.050881
0.02544
0.021526
0.019569
0.015656
0.02544
0.074364
0.04501
0.062622
0.019569
0.015656
0.009785
0.021526
0.043053
0.035225
0.043053
0.031311
0.035225
0.052838
0.017613
0.021526
0.029354
0
31,142
T
G
C
T
C
C
T
G
G
C
A
T
C
C
G
A
T
G
T
G
T
A
A
A
G
G
C
T
G
G
G
A
T
G
C
T
G
C
T
C
G
A
C
A
T
C
C
T
A
C
A
A
T
G
G
A
C
A
G
G
A
C
A
G
A
A
0.04501
0.023483
0.027397
0.031311
0.043053
0.029354
0.005871
0.031311
0.04501
0.037182
0.031311
0.04501
0.033268
0.023483
0.027397
0.033268
0.062622
0.050881
0.052838
0.015656
0.013699
0.003914
0.027397
0.031311
0.02544
0.029354
0.029354
0.031311
0.037182
0.023483
0.029354
0.023483
0
31,143
C
A
G
A
A
G
G
G
C
G
G
C
G
G
G
C
A
G
C
A
G
C
A
G
C
A
G
C
C
A
G
A
C
G
C
T
G
A
G
C
C
G
G
G
G
C
C
C
C
A
T
G
G
T
G
G
C
G
C
G
C
C
C
G
A
G
0.005871
0.007828
0.017613
0.007828
0.009785
0.029354
0.023483
0.003914
0.015656
0.058708
0.041096
0
0.003914
0.007828
0.017613
0.023483
0.041096
0.035225
0.105675
0.101761
0.027397
0.109589
0.009785
0.050881
0.013699
0.027397
0.037182
0.103718
0.04501
0.007828
0.001957
0.007828
0
31,144
G
A
G
G
C
T
G
G
G
A
G
A
G
A
C
A
T
G
C
A
G
G
C
T
C
A
T
T
T
T
C
A
T
G
T
C
C
A
A
A
C
A
C
G
T
G
A
G
T
G
G
G
G
G
A
T
G
G
A
T
T
T
C
A
C
C
0.031311
0.013699
0.037182
0.005871
0.027397
0.02544
0.017613
0.021526
0.033268
0.050881
0.07045
0.001957
0.015656
0.031311
0.017613
0.039139
0.066536
0.050881
0.064579
0.017613
0.003914
0.015656
0.011742
0.060665
0.027397
0.033268
0.039139
0.050881
0.062622
0.005871
0.011742
0.037182
0
31,145
A
C
C
C
A
G
G
G
A
G
G
C
C
G
T
G
T
T
G
G
C
C
G
G
G
G
T
C
T
C
C
T
C
T
G
T
C
C
C
C
T
T
T
C
C
T
C
C
C
C
G
G
C
T
C
C
C
C
G
T
T
G
A
T
G
T
0.023483
0.019569
0.043053
0.009785
0.033268
0.031311
0.011742
0.019569
0.039139
0.037182
0.062622
0.011742
0.013699
0.035225
0.02544
0.035225
0.050881
0.04501
0.07045
0.029354
0.005871
0.019569
0.013699
0.050881
0.033268
0.031311
0.037182
0.050881
0.052838
0.011742
0.013699
0.031311
0
31,146
G
T
C
C
T
G
G
C
A
G
G
C
C
T
G
G
C
A
A
T
C
C
C
T
T
G
G
G
C
C
C
T
C
C
T
A
T
G
C
A
A
C
C
T
G
G
G
G
A
C
A
G
A
A
A
G
G
A
G
A
A
A
A
G
A
G
0.056751
0.019569
0.033268
0.037182
0.033268
0.02544
0.009785
0.033268
0.033268
0.027397
0.043053
0.017613
0.029354
0.033268
0.033268
0.039139
0.054795
0.054795
0.062622
0.009785
0.005871
0.005871
0.019569
0.027397
0.02544
0.027397
0.04501
0.039139
0.043053
0.015656
0.031311
0.027397
0
31,147
C
A
G
G
C
T
T
C
G
C
A
G
G
A
G
C
T
G
A
T
G
G
A
G
G
A
C
C
A
G
G
G
C
C
C
A
G
G
G
G
C
T
T
G
C
C
A
G
G
A
G
A
C
G
C
A
G
G
T
C
G
T
G
A
A
T
0.056751
0.033268
0.031311
0.039139
0.031311
0.033268
0.007828
0.017613
0.027397
0.037182
0.046967
0.027397
0.039139
0.039139
0.031311
0.02544
0.058708
0.052838
0.048924
0.009785
0.007828
0.005871
0.011742
0.027397
0.041096
0.019569
0.02544
0.029354
0.046967
0.013699
0.031311
0.04501
0
31,148
A
G
A
C
T
T
G
A
A
A
T
T
G
A
C
A
A
T
T
T
G
G
G
G
T
C
C
T
G
A
G
A
T
T
G
A
A
A
C
A
G
G
A
G
T
C
A
A
A
A
C
C
A
G
A
G
C
C
C
A
G
G
G
T
A
C
0.029354
0.021526
0.023483
0.011742
0.031311
0.046967
0.011742
0.019569
0.031311
0.043053
0.064579
0.007828
0.011742
0.011742
0.02544
0.050881
0.07045
0.052838
0.060665
0.027397
0.013699
0.029354
0.011742
0.052838
0.023483
0.027397
0.043053
0.056751
0.041096
0.007828
0.007828
0.031311
0
31,149
C
T
C
A
G
C
C
C
G
C
T
G
A
T
T
T
T
T
G
G
T
C
T
T
T
T
G
T
C
C
T
T
T
G
A
T
C
C
A
G
C
A
G
T
T
C
C
C
A
C
G
T
G
G
A
T
G
T
T
G
T
A
C
T
G
G
0.029354
0.027397
0.041096
0.009785
0.04501
0.031311
0.023483
0.031311
0.029354
0.050881
0.056751
0.001957
0.013699
0.021526
0.02544
0.046967
0.074364
0.041096
0.037182
0.011742
0.007828
0.015656
0.017613
0.035225
0.029354
0.041096
0.037182
0.04501
0.035225
0.015656
0.023483
0.046967
0
31,150
T
T
T
T
G
C
C
G
T
T
G
A
A
T
A
A
G
C
G
T
T
C
C
C
A
C
G
A
G
C
A
A
T
G
A
T
T
C
C
T
T
C
A
A
T
G
A
A
A
G
A
A
A
T
T
A
T
C
T
G
A
G
G
A
A
A
0.088063
0.02544
0.035225
0.02544
0.027397
0.041096
0.021526
0.021526
0.035225
0.041096
0.048924
0.017613
0.007828
0.023483
0.027397
0.043053
0.052838
0.037182
0.037182
0.015656
0.009785
0.011742
0.013699
0.04501
0.04501
0.023483
0.037182
0.027397
0.033268
0.019569
0.015656
0.04501
0
31,151
A
T
A
G
G
A
A
G
A
C
A
G
A
G
A
C
C
T
C
A
G
T
G
A
A
A
A
T
G
T
T
C
C
T
C
A
A
G
G
A
C
C
T
C
A
C
A
C
C
A
T
T
C
C
T
T
T
G
A
C
T
C
A
T
G
T
0.07045
0.029354
0.046967
0.039139
0.043053
0.017613
0.005871
0.033268
0.046967
0.035225
0.037182
0.039139
0.017613
0.033268
0.043053
0.035225
0.041096
0.037182
0.027397
0.005871
0
0.007828
0.02544
0.037182
0.04501
0.027397
0.02544
0.029354
0.033268
0.009785
0.027397
0.046967
0
31,152
A
C
A
T
T
C
G
A
T
T
C
T
G
A
G
T
T
A
T
A
A
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A
T
C
A
T
A
T
A
A
T
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A
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T
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C
A
C
T
T
C
T
G
G
G
G
G
A
T
G
A
A
T
A
G
G
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31,153
G
G
A
A
C
T
T
T
G
A
C
C
C
C
T
A
T
A
C
C
T
C
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C
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G
G
T
C
T
T
G
C
A
G
A
T
G
T
G
C
T
G
C
A
C
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0.04501
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0
31,154
C
T
C
T
A
G
C
C
T
T
G
T
G
C
T
G
C
C
T
G
G
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G
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C
G
C
A
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C
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C
A
C
C
T
T
C
T
G
G
G
T
G
C
A
G
C
T
G
C
T
0.054795
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0
31,155
G
G
A
C
A
C
C
A
G
T
T
A
C
T
C
A
C
A
A
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A
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C
T
A
A
A
G
T
T
C
T
G
G
C
C
A
G
C
C
C
T
G
T
0.041096
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0.031311
0.009785
0.023483
0.039139
0
31,156
T
C
C
T
G
C
A
T
G
T
C
A
C
T
T
G
T
C
T
T
G
C
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C
A
T
T
G
A
T
G
C
G
A
C
T
C
C
A
C
T
C
C
G
0.027397
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0
31,157
T
C
T
T
T
G
A
T
T
A
C
A
G
C
A
C
A
C
A
C
T
C
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C
T
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G
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T
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C
C
T
G
G
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C
C
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G
T
T
G
T
C
A
T
G
T
A
G
C
T
G
G
T
G
T
C
A
0.033268
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0.027397
0.039139
0.048924
0.031311
0.050881
0.015656
0.029354
0.037182
0
31,158
C
T
G
C
C
A
T
G
C
T
C
C
C
T
C
C
A
G
C
T
G
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G
A
C
A
G
T
T
T
C
C
C
A
T
C
C
T
T
G
G
T
T
0.013699
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0.043053
0.041096
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0.031311
0.074364
0.009785
0.011742
0.037182
0
31,159
C
G
G
C
T
C
A
T
C
C
C
G
A
A
A
G
G
G
C
T
C
A
C
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C
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A
C
A
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T
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A
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A
G
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G
T
T
T
A
T
C
A
G
G
G
C
T
T
T
G
C
C
0.048924
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0.037182
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0.027397
0.017613
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0.039139
0.04501
0.023483
0.04501
0.02544
0.033268
0.015656
0.015656
0.060665
0
31,160
C
C
A
C
A
G
C
T
G
C
C
G
G
C
A
C
A
G
G
A
C
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T
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C
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A
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C
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C
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A
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G
G
C
T
G
A
T
G
G
T
C
A
C
C
A
G
C
A
G
C
A
T
0.033268
0.029354
0.021526
0.015656
0.039139
0.023483
0.02544
0.031311
0.033268
0.033268
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0.035225
0.066536
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0.031311
0.007828
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0.048924
0.02544
0.029354
0.029354
0.060665
0.039139
0.02544
0.015656
0.052838
0
31,161
T
G
C
A
A
G
T
T
T
T
C
A
A
G
T
T
T
C
A
T
C
C
C
C
G
A
A
A
T
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T
C
C
A
A
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C
A
C
T
C
C
T
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G
A
G
G
T
G
G
A
G
C
C
C
T
G
G
A
C
T
G
G
G
T
0.021526
0.011742
0.027397
0.015656
0.019569
0.033268
0.015656
0.029354
0.017613
0.052838
0.064579
0.001957
0.009785
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0.021526
0.050881
0.074364
0.046967
0.109589
0.023483
0.007828
0.003914
0.007828
0.054795
0.023483
0.031311
0.048924
0.054795
0.048924
0.003914
0.009785
0.04501
0
31,162
C
C
T
G
C
T
G
G
C
A
G
C
C
C
G
C
A
G
T
G
C
C
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C
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G
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C
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C
T
C
T
G
G
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C
C
A
G
G
A
C
A
A
A
C
T
C
T
A
A
A
T
A
T
T
G
T
C
C
C
T
C
G
0.023483
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0.078278
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0.019569
0.041096
0.04501
0.039139
0.052838
0.007828
0.007828
0.031311
0
31,163
C
C
C
G
G
A
G
G
A
A
G
G
A
A
T
G
G
C
A
G
G
G
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C
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A
C
T
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T
C
C
C
C
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G
T
G
C
T
C
A
G
A
A
G
C
A
G
C
A
G
A
C
T
C
C
A
T
G
0.072407
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0.027397
0.041096
0.052838
0.043053
0.007828
0.015656
0.027397
0
31,164
A
G
C
T
G
A
C
G
A
T
G
C
C
C
G
T
C
A
G
G
T
A
C
C
A
C
G
T
G
C
C
C
C
G
G
T
A
G
T
G
G
G
T
G
G
C
A
T
G
T
G
G
G
C
C
T
C
C
A
C
T
G
T
C
C
T
0.013699
0.009785
0.019569
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0.07045
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0.02544
0
31,165
A
G
C
C
T
G
C
T
G
T
T
G
G
G
C
T
G
C
G
T
T
T
C
C
T
A
G
G
C
A
G
C
C
A
C
G
T
G
G
T
C
C
C
C
A
G
G
G
C
C
C
C
A
G
A
G
G
T
A
A
A
C
C
C
T
A
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0.017613
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0.021526
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0.043053
0.029354
0.035225
0.058708
0.050881
0.007828
0.007828
0.02544
0
31,166
T
G
A
A
C
T
T
G
T
C
T
C
C
A
T
C
T
T
C
C
A
C
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C
C
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C
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T
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G
G
G
A
C
T
T
T
T
A
A
T
C
A
G
C
A
C
A
C
G
T
G
C
T
T
T
G
C
C
A
C
0.084149
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0.021526
0.031311
0.027397
0.048924
0.035225
0
31,167
A
G
A
C
A
G
G
C
C
T
T
C
C
C
C
A
A
C
C
A
C
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C
G
C
C
C
C
C
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G
C
G
C
C
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C
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G
C
C
C
C
T
C
G
C
C
C
T
C
A
C
C
C
G
T
G
C
C
C
A
T
0.017613
0.027397
0.021526
0.005871
0.033268
0.035225
0.029354
0.021526
0.048924
0.043053
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0.021526
0.033268
0.046967
0.048924
0.037182
0.015656
0.011742
0.033268
0
31,168
C
T
T
C
A
G
A
C
C
A
A
T
G
A
G
C
G
T
C
A
G
G
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C
C
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A
A
A
G
T
G
A
G
G
C
C
C
C
G
A
G
T
A
C
A
T
0.021526
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0.029354
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0.013699
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0.023483
0.037182
0.021526
0.07045
0.052838
0.011742
0.001957
0.031311
0
31,169
G
C
C
C
C
C
A
A
C
C
C
C
A
A
T
G
G
C
C
A
T
C
C
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T
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C
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C
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T
G
C
C
C
A
C
C
A
T
G
T
C
T
G
A
G
G
C
T
T
0.009785
0.017613
0.017613
0.005871
0.039139
0.037182
0.011742
0.007828
0.019569
0.043053
0.076321
0
0.011742
0.013699
0.019569
0.039139
0.084149
0.052838
0.111546
0.041096
0.009785
0.027397
0.005871
0.039139
0.021526
0.035225
0.04501
0.076321
0.056751
0.001957
0
0.021526
0
31,170
C
T
G
T
G
T
C
A
G
G
G
G
A
C
G
C
T
C
C
T
G
G
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C
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C
T
C
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G
G
G
A
C
A
C
T
G
G
C
C
C
G
G
A
A
0.011742
0.011742
0.015656
0.003914
0.031311
0.04501
0.011742
0.009785
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0.013699
0.037182
0.046967
0.074364
0.052838
0.005871
0
0.021526
0
31,171
G
C
C
A
C
C
G
C
T
C
C
G
G
C
T
C
G
C
G
G
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T
C
C
A
C
G
C
G
G
A
A
C
G
C
C
C
C
G
C
G
C
0.003914
0.011742
0.011742
0
0.005871
0.023483
0.021526
0.007828
0.011742
0.041096
0.046967
0
0.009785
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0.013699
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0.117417
0.125245
0.04501
0.113503
0.003914
0.056751
0.017613
0.029354
0.027397
0.121331
0.050881
0.003914
0
0.005871
0
31,172
T
T
T
G
T
C
T
T
C
A
T
T
T
T
C
A
A
T
C
T
A
C
A
T
T
A
A
A
A
A
C
A
T
A
C
A
C
G
T
G
A
A
C
A
A
T
T
T
C
A
A
C
A
A
C
A
T
G
T
C
T
T
C
T
G
C
0.076321
0.039139
0.046967
0.043053
0.048924
0.013699
0.013699
0.029354
0.060665
0.035225
0.023483
0.031311
0.031311
0.035225
0.037182
0.015656
0.054795
0.033268
0.015656
0.003914
0.009785
0.003914
0.019569
0.027397
0.050881
0.031311
0.02544
0.013699
0.033268
0.017613
0.041096
0.037182
0
31,173
G
C
A
T
T
T
T
A
G
T
T
T
G
T
C
T
T
C
A
T
T
T
T
C
A
A
T
C
T
A
C
A
T
T
A
A
A
A
A
C
A
T
A
C
A
C
G
T
G
A
A
C
A
A
T
T
T
C
A
A
C
A
A
C
A
C
0.076321
0.039139
0.046967
0.043053
0.046967
0.015656
0.013699
0.029354
0.058708
0.035225
0.027397
0.023483
0.031311
0.035225
0.037182
0.015656
0.054795
0.033268
0.015656
0.003914
0.009785
0.003914
0.021526
0.027397
0.048924
0.033268
0.02544
0.013699
0.035225
0.017613
0.043053
0.037182
0
31,174
T
A
C
A
C
A
A
A
G
C
G
T
T
T
A
C
C
T
A
G
A
A
G
A
T
G
C
A
C
T
G
G
C
G
C
C
C
G
C
C
T
G
T
A
T
G
A
G
A
G
T
C
G
G
C
A
T
G
A
C
G
G
C
C
A
T
0.09002
0.017613
0.037182
0.029354
0.039139
0.017613
0.021526
0.041096
0.027397
0.035225
0.035225
0.023483
0.017613
0.031311
0.041096
0.043053
0.043053
0.031311
0.021526
0.015656
0.011742
0.017613
0.015656
0.043053
0.019569
0.029354
0.048924
0.033268
0.031311
0.027397
0.023483
0.039139
0
31,175
T
T
C
A
G
G
T
T
G
G
C
C
G
G
T
G
T
C
A
G
C
C
G
T
G
C
G
T
C
A
T
C
C
G
G
A
A
G
G
C
T
G
C
C
A
T
A
A
G
C
C
T
G
C
G
T
T
T
C
G
C
A
G
A
G
T
0.052838
0.02544
0.041096
0.013699
0.035225
0.019569
0.031311
0.013699
0.046967
0.048924
0.029354
0.013699
0.033268
0.021526
0.031311
0.031311
0.056751
0.02544
0.023483
0.046967
0.021526
0.041096
0.011742
0.029354
0.039139
0.033268
0.039139
0.054795
0.02544
0.009785
0.011742
0.041096
0