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int64
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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C
G
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32,379
T
G
T
G
T
C
T
G
G
G
G
T
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G
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C
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G
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G
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C
C
T
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G
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G
G
T
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A
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A
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A
A
A
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T
G
A
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C
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C
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A
A
G
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T
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32,380
G
G
G
A
C
C
C
G
G
C
C
G
G
C
T
G
C
A
G
G
T
C
G
G
C
G
T
C
C
A
C
C
T
G
C
C
T
C
T
T
C
C
T
G
G
C
G
C
C
G
C
C
C
T
G
G
C
T
G
C
T
G
C
C
C
G
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0.017613
0
32,381
C
G
A
G
G
A
G
T
C
G
G
G
A
G
G
G
G
G
C
G
G
C
T
C
C
T
C
C
A
T
C
T
C
C
T
C
C
G
A
T
C
T
G
A
A
G
T
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G
C
C
T
C
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A
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C
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T
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0
32,382
A
A
C
C
A
A
G
T
C
A
C
C
T
G
T
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A
G
G
G
T
G
T
C
T
G
A
A
A
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C
T
T
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G
G
G
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C
T
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C
T
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0
32,383
T
T
C
C
C
G
T
C
C
T
T
C
C
C
G
C
A
G
T
T
C
A
C
C
A
A
C
C
G
C
T
G
C
C
T
G
C
T
C
A
A
G
T
G
G
C
T
G
A
A
G
T
T
G
T
G
G
G
A
C
C
T
G
G
T
T
0.003914
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0
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0
0
0.02544
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32,384
T
G
T
C
C
T
C
T
G
A
C
C
T
C
C
C
C
C
A
A
G
G
C
C
G
C
C
A
T
C
A
A
C
G
T
C
C
T
C
C
T
G
A
G
C
A
T
C
C
T
G
A
A
C
C
G
C
A
A
G
G
G
G
C
C
T
0.001957
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0.031311
0
32,385
G
A
A
G
A
C
A
C
C
C
G
C
C
T
G
C
A
T
T
T
C
T
G
A
G
C
T
C
C
C
A
A
C
C
A
G
C
T
C
A
G
G
A
A
C
A
G
C
G
C
A
G
C
C
G
C
T
C
G
C
A
A
A
T
G
G
0.011742
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0
32,386
C
C
G
A
C
A
C
G
G
C
C
T
C
C
C
C
A
T
C
C
C
T
G
G
G
T
C
C
A
C
C
C
C
G
A
C
T
C
C
C
A
T
G
G
T
G
G
G
G
A
G
C
G
G
C
C
G
G
C
T
T
G
G
A
G
T
0.003914
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0
0
0.017613
0
32,387
A
G
G
A
C
G
G
T
G
C
C
G
A
G
G
G
A
G
G
C
G
T
C
A
G
C
A
C
G
G
A
G
C
A
A
A
A
C
A
T
T
C
G
C
A
C
A
T
G
A
T
G
G
C
C
G
A
G
A
G
C
T
C
C
G
G
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0
0
0.011742
0
32,388
A
C
C
T
A
G
A
G
A
C
G
G
A
T
G
G
T
C
G
C
A
C
G
C
A
T
G
A
T
T
G
T
C
G
G
C
A
T
C
T
C
A
C
A
G
G
T
G
T
G
A
T
T
A
C
C
A
C
C
G
C
T
T
C
C
G
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0
32,389
C
A
C
G
G
A
T
C
A
G
A
T
C
A
C
A
A
G
C
G
C
C
C
A
T
C
A
C
T
G
C
C
C
T
C
C
G
T
G
C
A
T
A
C
T
G
G
G
A
A
G
G
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G
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T
G
G
C
A
G
A
G
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A
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32,390
G
A
G
C
C
T
G
A
C
C
T
G
G
G
A
G
C
T
G
C
A
A
C
G
A
G
G
A
A
A
T
A
C
C
G
A
G
G
A
A
A
T
A
C
C
G
T
G
T
C
G
C
C
C
G
A
G
C
A
G
C
C
A
A
C
A
0.109589
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32,391
G
C
T
A
T
T
T
C
T
T
T
C
T
G
A
T
T
C
T
G
A
A
A
C
A
A
A
G
T
A
T
T
T
A
T
C
G
G
C
C
A
T
G
C
C
T
G
C
T
G
T
T
G
G
C
T
G
C
T
C
G
G
G
C
G
C
0.109589
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0.011742
0.037182
0.048924
0.023483
0.021526
0.017613
0.035225
0
32,392
C
C
G
T
G
T
G
G
A
G
A
T
G
G
G
C
C
G
G
A
G
A
G
C
C
T
G
C
G
G
G
G
C
C
A
C
G
C
C
C
C
G
G
C
G
C
G
G
G
C
G
G
C
G
A
C
T
C
A
G
G
C
T
C
C
T
0
0.001957
0.017613
0.005871
0.021526
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0
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0.029354
0.121331
0.054795
0.007828
0
0.015656
0
32,393
G
C
T
G
G
T
G
C
C
C
G
T
G
C
T
G
T
A
C
C
T
G
C
T
G
G
T
G
T
G
T
G
C
G
G
C
C
G
G
G
C
T
G
G
G
C
G
G
G
A
A
C
A
C
G
C
T
G
G
T
C
A
T
C
T
T
0.001957
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0
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0.04501
0.084149
0.041096
0.011742
0
0.029354
0
32,394
C
G
C
A
G
A
A
C
G
C
C
G
C
G
T
C
C
T
T
C
T
G
G
C
C
C
T
T
C
G
G
C
C
C
C
G
T
C
C
T
G
T
G
C
C
G
C
C
T
G
G
T
C
A
T
G
A
C
G
C
T
G
G
A
C
T
0.001957
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0
0.005871
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0.041096
0.046967
0.093933
0.02544
0.017613
0
0.02544
0
32,395
C
T
C
T
G
G
T
G
C
C
A
A
G
G
A
C
G
C
T
G
A
C
G
C
C
A
C
G
G
A
G
C
C
G
C
G
T
C
C
A
G
A
C
A
G
G
A
T
C
C
G
G
C
A
G
C
A
G
C
A
G
G
A
G
G
T
0.001957
0.023483
0.02544
0
0.029354
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0.011742
0.031311
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0.046967
0.072407
0.043053
0.009785
0.001957
0.02544
0
32,396
C
C
C
C
G
G
A
C
C
C
A
A
G
G
G
G
A
A
G
T
G
G
G
C
C
G
G
T
G
G
A
C
C
G
C
C
A
G
G
C
A
C
C
G
G
G
G
G
G
C
A
C
G
G
C
C
C
G
T
T
G
A
G
C
T
T
0.007828
0.007828
0.021526
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0.02544
0.04501
0.011742
0.015656
0.027397
0.037182
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0.029354
0.052838
0.084149
0.035225
0.005871
0.001957
0.023483
0
32,397
C
C
C
T
G
A
T
C
C
C
T
A
C
G
A
G
A
A
G
A
T
C
C
C
G
C
A
T
G
T
G
G
T
C
G
G
G
G
A
G
C
A
T
G
G
T
G
A
G
G
A
C
C
C
A
G
C
C
C
C
A
C
C
C
C
C
0.009785
0.007828
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0.003914
0.02544
0.04501
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0.02544
0.046967
0.086106
0.039139
0.005871
0.001957
0.027397
0
32,398
G
C
C
T
C
T
G
G
G
T
T
A
C
C
T
T
C
A
G
C
G
G
C
A
A
G
C
T
G
C
G
C
C
G
C
A
T
C
G
T
G
G
A
C
A
G
C
A
A
G
T
A
C
T
T
C
A
G
C
C
G
T
G
G
C
T
0.003914
0.003914
0.017613
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0.015656
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0.031311
0.011742
0.017613
0.054795
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0.013699
0.035225
0.046967
0.09002
0.041096
0.011742
0.001957
0.037182
0
32,399
G
T
C
A
C
C
A
T
C
G
C
C
C
T
G
G
A
G
A
G
G
C
C
T
G
A
C
A
T
T
G
A
T
C
C
C
G
G
C
A
G
C
A
C
C
G
T
G
A
G
T
C
A
G
C
C
A
A
C
C
C
C
A
T
C
C
0.003914
0.013699
0.021526
0.007828
0.021526
0.046967
0.029354
0.013699
0.031311
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0.02544
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0.060665
0.046967
0.064579
0.107632
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0
0.043053
0.02544
0.033268
0.02544
0.058708
0.054795
0.005871
0.001957
0.037182
0
32,400
C
A
G
C
C
A
A
T
G
G
G
A
T
C
T
G
G
A
G
G
G
A
G
G
C
A
C
A
G
G
A
C
T
C
T
G
C
G
G
G
C
G
G
A
G
A
G
T
G
C
A
C
A
G
A
G
G
C
A
A
C
G
G
A
G
C
0
0.005871
0.023483
0.005871
0.017613
0.021526
0.015656
0.007828
0.039139
0.048924
0.088063
0
0.021526
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0.017613
0.02544
0.084149
0.058708
0.103718
0.027397
0.013699
0.017613
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0.068493
0.015656
0.029354
0.056751
0.080235
0.072407
0.001957
0.001957
0.009785
0
32,401
T
A
C
G
A
G
T
G
C
G
G
A
C
G
C
T
G
G
C
G
G
G
C
C
G
T
G
G
G
G
A
G
C
G
T
G
G
T
G
G
G
G
A
C
T
G
C
A
G
G
G
A
G
C
C
C
C
C
C
T
G
G
G
T
C
T
0.007828
0.003914
0.015656
0.003914
0.019569
0.037182
0.015656
0.013699
0.021526
0.050881
0.07045
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0.013699
0.011742
0.007828
0.041096
0.07045
0.060665
0.09002
0.056751
0.021526
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0.060665
0.013699
0.031311
0.029354
0.09589
0.054795
0.011742
0.001957
0.021526
0
32,402
C
G
C
C
T
G
G
G
G
C
C
G
C
C
G
G
C
C
G
G
C
T
G
G
A
G
A
C
G
C
A
G
C
G
C
T
G
T
C
C
G
A
A
G
G
T
A
T
G
C
T
T
A
C
G
A
G
T
G
C
G
G
A
C
G
T
0.005871
0.001957
0.017613
0.003914
0.021526
0.029354
0.017613
0.011742
0.021526
0.058708
0.062622
0.001957
0.011742
0.009785
0.007828
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0.068493
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0.09002
0.07045
0.02544
0.039139
0.007828
0.060665
0.013699
0.031311
0.033268
0.105675
0.050881
0.007828
0.001957
0.019569
0
32,403
C
C
A
G
G
T
G
A
A
C
G
G
T
G
C
C
T
G
G
G
T
G
C
A
G
G
C
T
G
G
C
A
C
T
G
T
G
A
G
C
T
G
G
G
G
T
G
A
G
G
G
C
T
G
C
G
G
C
C
G
C
C
C
C
A
T
0
0.005871
0.019569
0.001957
0.029354
0.021526
0.011742
0.021526
0.033268
0.041096
0.062622
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0.005871
0.039139
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0.046967
0.105675
0.054795
0.009785
0.017613
0.009785
0.046967
0.021526
0.029354
0.048924
0.091977
0.050881
0.011742
0
0.027397
0
32,404
G
G
G
G
C
T
G
A
G
C
A
G
T
G
A
C
C
C
G
C
C
G
C
A
C
A
C
G
T
G
C
A
C
C
C
T
C
C
G
C
A
G
G
C
G
G
A
G
G
C
T
G
G
C
C
T
G
C
C
A
T
G
G
C
C
T
0.009785
0.009785
0.041096
0.003914
0.013699
0.035225
0.011742
0.031311
0.035225
0.041096
0.056751
0
0.011742
0.023483
0.019569
0.056751
0.060665
0.058708
0.074364
0.039139
0.013699
0.02544
0.003914
0.056751
0.033268
0.023483
0.058708
0.07045
0.048924
0.001957
0.001957
0.027397
0
32,405
G
G
A
C
C
C
T
G
G
C
T
G
T
C
C
G
T
A
G
G
G
T
G
A
G
C
C
T
G
T
G
T
C
C
T
C
C
A
C
T
C
C
C
G
T
C
C
T
G
C
C
A
G
G
C
G
G
C
C
T
T
G
G
C
T
G
0.017613
0.015656
0.017613
0.011742
0.037182
0.035225
0.02544
0.017613
0.035225
0.039139
0.060665
0.009785
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0.015656
0.019569
0.056751
0.066536
0.064579
0.068493
0.035225
0.005871
0.013699
0.017613
0.050881
0.015656
0.035225
0.035225
0.076321
0.048924
0.009785
0.009785
0.021526
0
32,406
A
G
G
A
C
G
G
G
A
G
T
G
G
A
G
G
A
C
A
C
A
G
G
C
T
C
A
C
C
C
T
A
C
G
G
A
C
A
G
C
C
A
G
G
G
T
C
C
A
C
G
C
C
T
C
T
G
T
G
G
G
G
A
A
G
G
0.017613
0.015656
0.017613
0.009785
0.035225
0.033268
0.023483
0.017613
0.033268
0.043053
0.062622
0.009785
0.009785
0.017613
0.019569
0.052838
0.066536
0.062622
0.068493
0.039139
0.005871
0.013699
0.017613
0.054795
0.013699
0.031311
0.035225
0.080235
0.050881
0.009785
0.009785
0.021526
0
32,407
G
C
T
C
T
C
C
C
T
G
C
C
G
T
C
A
G
A
G
C
C
C
T
C
A
C
C
C
T
G
G
G
C
C
C
C
A
C
A
C
A
C
A
G
G
T
C
C
C
C
C
T
G
C
G
C
A
G
T
G
G
C
T
C
G
A
0.011742
0.007828
0.019569
0
0.021526
0.04501
0.009785
0.011742
0.029354
0.04501
0.084149
0.001957
0.009785
0.015656
0.007828
0.054795
0.076321
0.056751
0.113503
0.02544
0.015656
0.019569
0.003914
0.072407
0.013699
0.015656
0.056751
0.074364
0.046967
0.007828
0.005871
0.019569
0
32,408
C
C
C
A
C
A
A
C
T
G
C
A
C
C
T
G
C
T
C
T
C
G
G
G
G
A
C
T
C
T
T
G
T
C
A
T
T
C
A
G
G
A
T
C
C
T
G
T
C
G
T
A
C
C
A
C
T
C
A
C
G
G
T
T
G
G
0.003914
0.017613
0.033268
0.005871
0.035225
0.043053
0.017613
0.015656
0.033268
0.04501
0.072407
0.001957
0.011742
0.019569
0.027397
0.04501
0.078278
0.056751
0.068493
0.023483
0.015656
0.009785
0.009785
0.04501
0.027397
0.031311
0.054795
0.062622
0.04501
0.017613
0.001957
0.023483
0
32,409
A
C
A
G
T
G
A
G
G
G
T
G
T
G
A
G
C
T
G
C
T
G
C
A
C
C
T
G
C
T
C
C
T
G
G
C
T
G
T
G
G
G
G
C
T
T
C
T
C
C
A
G
G
A
C
C
C
C
T
C
C
T
G
G
C
C
0.017613
0.013699
0.023483
0.003914
0.029354
0.039139
0.007828
0.011742
0.017613
0.058708
0.066536
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0.009785
0.027397
0.013699
0.04501
0.086106
0.07045
0.109589
0.023483
0.001957
0.02544
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0.039139
0.017613
0.019569
0.04501
0.082192
0.039139
0.009785
0.007828
0.027397
0
32,410
G
C
T
C
A
G
G
G
C
C
C
T
G
C
G
G
A
G
G
C
C
A
G
G
A
G
G
G
G
T
C
C
T
G
G
A
G
A
A
G
C
C
C
C
A
C
A
G
C
C
A
G
G
A
G
C
A
G
G
T
G
C
A
G
C
C
0.013699
0.011742
0.021526
0.003914
0.031311
0.039139
0.007828
0.009785
0.017613
0.056751
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0.027397
0.013699
0.043053
0.088063
0.07045
0.109589
0.023483
0.001957
0.029354
0.003914
0.039139
0.015656
0.021526
0.043053
0.086106
0.039139
0.009785
0.007828
0.027397
0
32,411
G
G
C
C
A
T
G
T
G
C
C
G
C
A
T
C
T
C
T
G
G
A
C
A
G
G
T
G
G
C
T
G
C
G
C
T
G
G
A
A
G
G
C
G
T
C
C
C
T
C
A
T
A
A
A
G
C
T
C
A
G
G
G
C
C
T
0.011742
0.009785
0.021526
0.003914
0.027397
0.039139
0.007828
0.007828
0.015656
0.058708
0.07045
0.005871
0.013699
0.027397
0.011742
0.04501
0.086106
0.072407
0.105675
0.02544
0.001957
0.039139
0.003914
0.039139
0.015656
0.017613
0.043053
0.086106
0.041096
0.009785
0.007828
0.027397
0
32,412
G
G
C
C
T
G
G
A
G
G
C
T
G
T
A
C
C
T
G
G
C
C
T
T
G
C
C
T
T
C
G
G
C
G
G
A
A
A
T
C
C
T
G
A
G
G
T
C
T
G
A
G
T
C
G
C
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C
T
T
A
T
G
A
A
T
0.001957
0.007828
0.027397
0.003914
0.027397
0.043053
0.009785
0.013699
0.035225
0.037182
0.086106
0.005871
0.011742
0.005871
0.017613
0.043053
0.07045
0.062622
0.107632
0.029354
0.013699
0.021526
0.009785
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0.017613
0.027397
0.027397
0.082192
0.050881
0.015656
0.003914
0.019569
0
32,413
A
G
G
G
G
C
A
G
C
A
T
G
A
G
G
T
G
G
G
G
C
C
G
G
G
C
G
G
G
C
G
G
C
G
G
G
C
A
G
G
T
G
G
G
G
C
C
G
G
G
G
C
C
G
G
G
G
T
G
C
A
G
G
T
C
T
0.003914
0.005871
0.019569
0.001957
0.013699
0.033268
0.009785
0.011742
0.029354
0.056751
0.074364
0
0.005871
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0.003914
0.037182
0.09589
0.056751
0.105675
0.048924
0.011742
0.031311
0.001957
0.054795
0.023483
0.023483
0.052838
0.103718
0.043053
0.001957
0
0.02544
0
32,414
C
C
T
C
T
C
C
G
A
G
A
G
C
T
C
C
T
C
C
A
G
G
C
T
C
A
A
G
G
G
C
T
C
G
G
G
G
C
T
G
G
C
C
A
G
G
C
C
T
C
C
T
G
C
C
A
G
G
A
G
G
A
G
C
C
T
0.001957
0.009785
0.023483
0
0.017613
0.035225
0.017613
0.015656
0.023483
0.056751
0.066536
0.001957
0.011742
0.009785
0.023483
0.041096
0.064579
0.072407
0.091977
0.046967
0.019569
0.029354
0.001957
0.07045
0.007828
0.029354
0.033268
0.091977
0.058708
0.005871
0.001957
0.017613
0
32,415
C
A
G
A
A
G
G
G
C
C
G
G
G
G
T
G
C
C
A
G
C
G
C
C
A
G
T
G
C
C
C
A
T
T
A
T
G
G
G
C
A
G
G
G
C
T
G
G
G
C
C
T
C
A
C
G
T
C
T
G
G
G
C
C
A
C
0.011742
0.013699
0.019569
0.005871
0.029354
0.035225
0.009785
0.019569
0.021526
0.050881
0.07045
0.001957
0.003914
0.011742
0.019569
0.043053
0.084149
0.062622
0.093933
0.031311
0.017613
0.035225
0.003914
0.054795
0.015656
0.027397
0.048924
0.084149
0.04501
0.005871
0.003914
0.017613
0
32,416
G
G
C
A
A
C
T
G
T
G
G
C
C
G
T
G
A
C
G
G
C
G
G
C
C
A
C
C
A
G
C
A
C
G
G
C
C
T
C
A
A
T
C
A
C
C
T
G
C
A
G
G
C
A
G
G
G
C
C
G
G
T
G
G
A
T
0.027397
0.02544
0.017613
0.005871
0.023483
0.027397
0.019569
0.021526
0.015656
0.043053
0.064579
0
0.017613
0.019569
0.035225
0.037182
0.072407
0.056751
0.064579
0.039139
0.015656
0.031311
0.009785
0.04501
0.011742
0.021526
0.064579
0.088063
0.04501
0.009785
0.003914
0.019569
0
32,417
C
A
G
G
A
T
G
G
C
A
C
C
T
G
T
C
G
G
G
A
A
C
T
C
T
T
T
C
C
C
G
A
T
G
G
C
A
A
G
G
T
T
T
G
C
A
A
C
T
T
C
C
C
C
G
G
G
A
A
C
C
A
G
C
G
C
0.009785
0.013699
0.019569
0.011742
0.029354
0.029354
0.021526
0.011742
0.015656
0.04501
0.054795
0.007828
0.027397
0.027397
0.021526
0.050881
0.064579
0.066536
0.091977
0.039139
0.019569
0.029354
0.013699
0.029354
0.023483
0.021526
0.054795
0.078278
0.050881
0.005871
0
0.013699
0
32,418
C
T
G
G
T
G
C
T
G
C
A
C
G
G
C
C
G
A
G
A
C
T
C
C
C
T
G
C
T
G
C
C
C
G
G
A
T
C
C
A
T
C
C
A
C
T
T
C
G
T
G
A
T
C
G
G
G
G
A
C
C
C
G
G
C
T
0.011742
0.017613
0.019569
0.003914
0.023483
0.033268
0.033268
0.011742
0.019569
0.046967
0.066536
0.001957
0.023483
0.009785
0.017613
0.04501
0.072407
0.056751
0.076321
0.04501
0.027397
0.021526
0.007828
0.04501
0.023483
0.033268
0.046967
0.072407
0.062622
0.005871
0
0.017613
0
32,419
A
C
A
A
C
A
A
G
C
T
G
G
T
G
C
T
G
C
A
C
G
G
C
C
G
A
G
A
C
T
C
C
C
T
G
C
T
G
C
C
C
G
G
A
T
C
C
A
T
C
C
A
C
T
T
C
G
T
G
A
T
C
G
G
G
A
0.011742
0.017613
0.019569
0.003914
0.023483
0.033268
0.033268
0.011742
0.019569
0.048924
0.062622
0.001957
0.02544
0.011742
0.017613
0.04501
0.072407
0.058708
0.076321
0.04501
0.02544
0.021526
0.007828
0.043053
0.023483
0.033268
0.048924
0.068493
0.064579
0.005871
0
0.017613
0
32,420
C
G
T
G
G
T
C
T
T
C
C
T
C
A
G
C
C
C
T
G
G
T
T
T
C
G
T
C
A
C
T
G
C
C
C
T
G
C
G
A
G
C
C
C
T
G
T
C
C
T
T
C
T
G
C
A
G
C
T
G
G
G
T
C
C
A
0.011742
0.015656
0.023483
0.001957
0.021526
0.031311
0.037182
0.019569
0.02544
0.046967
0.062622
0
0.019569
0.011742
0.017613
0.056751
0.078278
0.056751
0.060665
0.039139
0.017613
0.019569
0.005871
0.046967
0.023483
0.031311
0.062622
0.07045
0.056751
0.005871
0
0.021526
0
32,421
T
G
A
C
G
A
A
A
C
C
A
G
G
G
C
T
G
A
G
G
A
A
G
A
C
C
A
C
G
T
T
C
C
T
G
G
T
G
G
A
G
G
C
G
T
T
T
G
G
G
A
A
A
A
C
G
A
G
G
G
T
G
G
G
G
T
0.011742
0.019569
0.02544
0.001957
0.023483
0.029354
0.029354
0.021526
0.02544
0.04501
0.060665
0
0.023483
0.013699
0.017613
0.054795
0.076321
0.052838
0.064579
0.041096
0.017613
0.021526
0.005871
0.04501
0.029354
0.029354
0.060665
0.068493
0.056751
0.001957
0
0.02544
0
32,422
G
A
G
A
G
G
G
G
C
C
G
A
G
G
A
G
T
C
C
T
G
T
G
G
G
G
G
G
C
C
C
C
T
G
T
G
C
T
C
A
G
A
G
G
C
A
G
C
T
C
G
G
A
G
C
T
C
C
T
G
C
C
T
G
T
C
0.013699
0.007828
0.02544
0
0.013699
0.023483
0.009785
0.019569
0.02544
0.054795
0.09002
0
0.003914
0.007828
0.011742
0.027397
0.086106
0.062622
0.103718
0.033268
0.013699
0.013699
0.003914
0.076321
0.015656
0.021526
0.037182
0.103718
0.058708
0.009785
0.005871
0.019569
0
32,423
G
G
G
A
C
A
G
G
C
A
G
G
A
G
C
T
C
C
G
A
G
C
T
G
C
C
T
C
T
G
A
G
C
A
C
A
G
G
G
G
C
C
C
C
C
C
A
C
A
G
G
A
C
T
C
C
T
C
G
G
C
C
C
C
T
A
0.013699
0.007828
0.02544
0
0.013699
0.023483
0.009785
0.019569
0.023483
0.056751
0.09002
0
0.003914
0.007828
0.011742
0.027397
0.088063
0.064579
0.103718
0.033268
0.013699
0.013699
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0.072407
0.015656
0.021526
0.037182
0.103718
0.058708
0.009785
0.005871
0.019569
0
32,424
C
G
T
C
C
A
C
A
G
C
C
A
G
G
G
C
G
C
C
A
G
G
C
T
G
G
C
T
G
C
T
C
T
G
G
A
G
G
G
G
C
G
G
C
T
G
C
C
C
G
T
G
G
C
C
C
A
C
C
C
T
G
G
C
A
C
0.007828
0.005871
0.021526
0
0.015656
0.02544
0.009785
0.017613
0.015656
0.062622
0.088063
0
0.001957
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0.015656
0.033268
0.091977
0.054795
0.09002
0.043053
0.019569
0.029354
0.001957
0.07045
0.011742
0.02544
0.046967
0.111546
0.048924
0.005871
0
0.02544
0
32,425
T
G
C
A
G
G
G
C
G
T
C
C
C
T
C
T
G
G
G
C
C
T
T
G
T
G
T
G
C
C
T
T
C
C
T
T
T
C
C
C
G
G
G
C
C
C
G
C
T
G
C
T
G
G
C
T
C
C
T
C
T
C
G
C
C
A
0.003914
0.017613
0.019569
0
0.029354
0.02544
0.021526
0.013699
0.017613
0.062622
0.082192
0
0.001957
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0.037182
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0.052838
0.072407
0.04501
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0.056751
0.017613
0.029354
0.04501
0.103718
0.048924
0.005871
0
0.023483
0
32,426
A
A
G
A
G
A
G
C
C
A
G
G
C
T
G
T
G
G
C
T
C
A
G
G
C
A
G
T
C
A
A
C
C
G
G
T
C
A
C
A
G
G
C
C
T
C
G
G
T
G
C
A
G
G
G
G
G
A
G
C
T
G
G
C
G
T
0.007828
0.017613
0.023483
0.001957
0.027397
0.021526
0.029354
0.015656
0.017613
0.052838
0.068493
0
0.007828
0.005871
0.021526
0.039139
0.074364
0.048924
0.058708
0.068493
0.009785
0.041096
0.005871
0.048924
0.019569
0.027397
0.041096
0.111546
0.052838
0.007828
0.001957
0.023483
0
32,427
A
A
G
G
T
G
G
A
C
C
T
G
T
G
A
C
C
T
C
C
C
A
G
T
T
T
C
C
A
C
T
C
C
C
C
A
T
G
A
C
A
C
T
A
C
C
C
G
G
C
C
C
C
C
A
T
G
G
C
C
C
C
C
A
G
T
0.013699
0.021526
0.027397
0.007828
0.043053
0.037182
0.019569
0.027397
0.019569
0.037182
0.046967
0.005871
0.017613
0.031311
0.013699
0.062622
0.058708
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0.035225
0.009785
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0.041096
0.031311
0.035225
0.023483
0.050881
0.056751
0.007828
0.011742
0.037182
0
32,428
A
T
G
A
A
T
G
G
C
T
T
C
C
C
G
G
A
C
G
G
C
G
A
G
T
C
G
A
A
C
C
T
C
T
G
A
G
G
G
T
G
C
T
G
G
C
T
C
C
A
T
C
C
T
G
C
A
G
G
A
C
A
G
A
T
G
0.005871
0.013699
0.027397
0.005871
0.02544
0.033268
0.013699
0.013699
0.033268
0.058708
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0.023483
0.013699
0.037182
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0.068493
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0.027397
0.027397
0.001957
0.07045
0.031311
0.031311
0.027397
0.062622
0.066536
0.003914
0.001957
0.023483
0
32,429
C
A
T
G
A
A
T
G
G
C
T
T
C
C
C
G
G
A
C
G
G
C
G
A
G
T
C
G
A
A
C
C
T
C
T
G
A
G
G
G
T
G
C
T
G
G
C
T
C
C
A
T
C
C
T
G
C
A
G
G
A
C
A
G
A
C
0.005871
0.013699
0.027397
0.005871
0.02544
0.033268
0.013699
0.013699
0.033268
0.058708
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0.013699
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0.07045
0.031311
0.031311
0.027397
0.062622
0.066536
0.003914
0.001957
0.023483
0
32,430
G
C
A
G
C
G
T
C
T
C
C
C
G
G
A
G
C
A
G
G
A
T
G
A
A
G
C
C
G
G
G
C
T
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C
G
T
C
T
G
C
T
G
C
C
G
A
C
A
C
T
G
C
G
C
C
T
C
C
A
T
C
A
G
C
C
0.009785
0.02544
0.031311
0.005871
0.017613
0.033268
0.019569
0.015656
0.029354
0.04501
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0.013699
0.027397
0.033268
0.07045
0.054795
0.076321
0.056751
0.019569
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0.037182
0.029354
0.021526
0.054795
0.082192
0.04501
0.005871
0.007828
0.017613
0
32,431
C
T
G
A
C
C
A
G
G
C
G
C
C
A
C
T
A
A
C
C
T
T
G
G
A
G
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C
C
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C
T
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G
G
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C
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C
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C
T
G
A
T
C
C
G
C
T
C
C
T
C
C
A
C
C
A
C
C
C
0.013699
0.011742
0.02544
0.007828
0.023483
0.04501
0.013699
0.023483
0.033268
0.043053
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0.04501
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0.017613
0.04501
0.037182
0.07045
0.054795
0.001957
0.003914
0.023483
0
32,432
C
T
C
A
C
G
C
C
C
T
G
A
A
C
G
T
G
G
G
G
C
C
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A
G
G
G
C
C
C
A
G
T
0.015656
0.017613
0.021526
0.005871
0.031311
0.031311
0.023483
0.017613
0.027397
0.043053
0.054795
0
0.017613
0.019569
0.023483
0.062622
0.068493
0.062622
0.076321
0.035225
0.021526
0.021526
0.003914
0.050881
0.015656
0.015656
0.064579
0.086106
0.035225
0.007828
0.005871
0.015656
0
32,433
C
C
T
G
C
T
G
A
G
C
T
C
C
C
C
C
G
A
G
G
A
C
A
T
G
A
T
C
G
A
G
G
C
G
G
C
C
C
G
A
T
A
C
T
A
C
G
A
G
G
A
G
A
A
G
G
G
C
G
T
G
C
A
G
A
T
0.015656
0.011742
0.029354
0.005871
0.023483
0.029354
0.011742
0.017613
0.021526
0.056751
0.064579
0.003914
0.023483
0.023483
0.019569
0.035225
0.072407
0.052838
0.080235
0.037182
0.023483
0.021526
0.005871
0.052838
0.021526
0.019569
0.041096
0.084149
0.041096
0.015656
0.005871
0.031311
0
32,434
C
T
G
A
G
A
T
G
T
G
G
G
C
A
G
C
C
C
A
C
A
C
C
T
C
C
C
G
G
A
G
A
T
G
G
A
G
G
T
A
C
C
A
C
C
G
T
G
G
G
A
C
T
G
G
G
C
T
C
C
C
T
G
G
C
C
0.011742
0.009785
0.013699
0.007828
0.033268
0.035225
0.019569
0.017613
0.023483
0.064579
0.052838
0.003914
0.011742
0.015656
0.007828
0.052838
0.082192
0.054795
0.078278
0.046967
0.011742
0.023483
0.009785
0.052838
0.015656
0.02544
0.052838
0.068493
0.050881
0.017613
0.007828
0.019569
0
32,435
C
C
T
G
G
C
C
G
G
C
T
C
T
G
G
C
C
C
C
A
G
G
G
C
T
C
G
G
C
C
C
T
C
C
C
C
G
G
G
T
C
C
T
G
T
C
C
A
C
C
A
G
C
C
A
G
C
A
G
G
A
C
C
T
C
G
0.007828
0.011742
0.013699
0.003914
0.017613
0.027397
0.033268
0.015656
0.019569
0.046967
0.062622
0.001957
0.011742
0.017613
0.013699
0.04501
0.068493
0.064579
0.062622
0.054795
0.017613
0.050881
0.005871
0.056751
0.009785
0.035225
0.037182
0.101761
0.050881
0.001957
0.005871
0.02544
0
32,436
T
C
T
C
T
T
G
C
T
C
A
T
T
A
A
A
G
G
A
C
A
G
C
G
T
C
T
C
T
C
T
C
C
G
A
T
C
A
A
T
T
T
G
T
C
C
A
G
T
C
T
T
G
A
A
G
T
C
A
A
A
G
A
C
G
T
0.048924
0.033268
0.050881
0.02544
0.04501
0.02544
0.009785
0.039139
0.056751
0.039139
0.035225
0.007828
0.019569
0.021526
0.039139
0.037182
0.056751
0.04501
0.023483
0.011742
0.005871
0.011742
0.02544
0.037182
0.048924
0.037182
0.023483
0.027397
0.039139
0.009785
0.021526
0.041096
0
32,437
G
G
C
C
C
G
C
T
C
G
C
T
G
A
G
G
A
T
G
G
C
C
A
C
G
G
A
G
A
T
G
A
C
G
C
T
G
T
T
C
A
C
T
G
C
C
A
G
C
A
G
G
T
T
C
T
T
C
C
T
G
G
A
A
C
T
0.029354
0.02544
0.048924
0.013699
0.046967
0.035225
0.011742
0.035225
0.050881
0.023483
0.031311
0.017613
0.019569
0.043053
0.019569
0.052838
0.058708
0.050881
0.039139
0.021526
0.013699
0.015656
0.003914
0.029354
0.046967
0.033268
0.04501
0.035225
0.033268
0.017613
0.019569
0.031311
0
32,438
A
A
C
C
T
G
A
G
G
T
C
G
A
G
A
G
T
T
C
A
A
G
A
C
C
A
G
C
C
T
G
G
C
C
A
A
C
A
T
G
G
T
G
A
A
A
C
T
C
C
G
T
C
T
G
T
A
C
T
A
A
A
A
A
T
A
0.050881
0.037182
0.033268
0.027397
0.037182
0.033268
0.015656
0.035225
0.031311
0.023483
0.039139
0.019569
0.023483
0.027397
0.033268
0.046967
0.046967
0.056751
0.046967
0.009785
0.017613
0.019569
0.009785
0.041096
0.027397
0.021526
0.029354
0.041096
0.031311
0.015656
0.037182
0.033268
0
32,439
G
G
C
C
A
T
G
C
T
C
A
C
C
T
T
C
T
T
C
T
T
C
T
C
G
G
G
A
G
A
C
G
T
G
T
G
G
G
C
G
C
T
C
T
T
G
G
G
C
T
C
G
C
C
G
T
C
T
C
C
T
T
C
G
C
C
0.007828
0.005871
0.027397
0.003914
0.019569
0.041096
0.011742
0.019569
0.027397
0.060665
0.058708
0
0.003914
0.015656
0.009785
0.046967
0.078278
0.054795
0.078278
0.041096
0.021526
0.046967
0.005871
0.056751
0.02544
0.039139
0.043053
0.068493
0.04501
0
0.001957
0.033268
0
32,440
A
T
C
C
T
G
G
A
T
G
T
G
G
A
C
C
T
G
T
G
T
G
G
C
C
C
C
A
G
T
A
T
C
C
C
C
C
G
C
A
T
G
C
T
C
G
G
G
G
C
G
C
A
G
G
G
C
A
G
G
G
C
T
G
T
A
0.015656
0.011742
0.021526
0.003914
0.021526
0.033268
0.023483
0.007828
0.023483
0.041096
0.064579
0.001957
0.015656
0.02544
0.007828
0.046967
0.064579
0.054795
0.074364
0.064579
0.007828
0.04501
0.007828
0.041096
0.02544
0.021526
0.052838
0.091977
0.056751
0.005871
0.003914
0.015656
0
32,441
C
G
G
C
T
G
C
A
A
G
G
T
G
G
C
C
T
T
A
G
T
C
A
G
G
G
G
A
G
G
C
A
C
G
C
G
G
G
C
G
T
C
G
C
G
T
C
C
A
G
A
A
T
C
T
T
C
T
G
G
G
C
T
A
T
T
0.005871
0.009785
0.019569
0.007828
0.011742
0.031311
0.023483
0.013699
0.033268
0.054795
0.066536
0.001957
0.009785
0.015656
0.009785
0.043053
0.084149
0.066536
0.072407
0.033268
0.015656
0.041096
0.005871
0.058708
0.023483
0.027397
0.054795
0.088063
0.046967
0
0.003914
0.019569
0
32,442
T
C
G
A
T
A
A
A
G
G
G
A
A
G
A
C
G
A
T
G
A
C
A
G
T
G
G
G
C
C
G
G
C
G
G
C
T
T
C
C
C
A
C
A
G
C
T
C
T
G
C
A
C
G
G
G
G
C
C
T
G
C
C
A
G
T
0.023483
0.007828
0.017613
0.009785
0.013699
0.029354
0.017613
0.019569
0.037182
0.033268
0.07045
0.005871
0.017613
0.005871
0.003914
0.041096
0.082192
0.052838
0.109589
0.043053
0.015656
0.017613
0.003914
0.056751
0.02544
0.027397
0.041096
0.084149
0.050881
0.003914
0.005871
0.02544
0
32,443
T
T
C
T
C
G
A
T
A
A
A
G
G
G
A
A
G
A
C
G
A
T
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A
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G
T
G
G
G
C
C
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G
C
G
G
C
T
T
C
C
C
A
C
A
G
C
T
C
T
G
C
A
C
G
G
G
G
C
C
T
G
C
T
0.023483
0.005871
0.017613
0.009785
0.013699
0.029354
0.017613
0.019569
0.037182
0.035225
0.07045
0.005871
0.017613
0.005871
0.001957
0.041096
0.082192
0.050881
0.109589
0.043053
0.015656
0.017613
0.003914
0.058708
0.02544
0.027397
0.041096
0.086106
0.050881
0.003914
0.005871
0.02544
0
32,444
A
G
T
C
C
A
G
G
G
C
A
G
C
C
C
C
T
T
C
T
T
C
T
T
G
C
A
C
T
C
G
T
C
C
T
G
C
A
C
G
T
C
C
C
G
G
G
C
G
G
T
C
A
T
A
T
C
C
A
G
G
C
A
C
A
T
0.011742
0.017613
0.035225
0.003914
0.017613
0.021526
0.041096
0.015656
0.029354
0.048924
0.048924
0.015656
0.029354
0.033268
0.021526
0.033268
0.048924
0.041096
0.050881
0.035225
0.019569
0.060665
0.013699
0.04501
0.029354
0.033268
0.039139
0.054795
0.046967
0.011742
0.005871
0.039139
0
32,445
T
T
T
T
A
C
T
T
A
T
T
A
T
G
C
A
T
T
T
T
C
A
A
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A
A
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A
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T
A
C
C
A
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A
A
G
C
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A
A
C
A
T
T
C
T
G
C
T
G
A
A
T
T
T
T
A
T
A
C
C
0.119374
0.029354
0.041096
0.088063
0.046967
0.019569
0.009785
0.023483
0.048924
0.017613
0.013699
0.056751
0.037182
0.048924
0.027397
0.019569
0.023483
0.02544
0.005871
0.003914
0.005871
0
0.031311
0.007828
0.046967
0.007828
0.011742
0.013699
0.009785
0.043053
0.080235
0.035225
0
32,446
A
T
T
A
T
T
G
A
A
A
C
C
T
A
C
C
A
G
A
T
T
A
G
C
C
A
T
A
T
T
T
G
T
C
T
G
C
A
G
A
T
C
T
G
A
A
A
G
G
G
T
A
G
T
G
A
A
A
A
T
C
C
T
C
G
G
0.086106
0.015656
0.027397
0.09002
0.033268
0.023483
0
0.02544
0.037182
0.015656
0.02544
0.068493
0.048924
0.052838
0.041096
0.023483
0.027397
0.035225
0.007828
0.003914
0.003914
0.003914
0.031311
0.017613
0.029354
0.011742
0.027397
0.023483
0.017613
0.031311
0.064579
0.048924
0
32,447
G
G
G
C
A
G
G
C
C
C
G
G
G
G
T
C
T
T
G
G
A
G
A
G
C
G
T
C
T
G
G
G
C
G
T
A
G
T
C
G
G
A
G
A
T
G
G
C
C
C
G
G
G
T
C
A
C
G
G
G
G
T
T
C
C
T
0.001957
0.007828
0.027397
0
0.015656
0.033268
0.037182
0.013699
0.02544
0.037182
0.046967
0.001957
0.017613
0.019569
0.007828
0.033268
0.056751
0.054795
0.109589
0.07045
0.021526
0.046967
0.009785
0.029354
0.02544
0.048924
0.029354
0.084149
0.054795
0.009785
0.001957
0.019569
0
32,448
G
A
A
G
A
C
C
C
C
C
A
G
C
T
A
C
T
T
C
G
T
G
A
C
G
C
G
A
G
A
G
G
C
C
C
C
C
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C
C
G
C
A
T
C
C
A
C
G
C
C
A
T
G
T
C
C
C
C
G
G
A
C
A
T
0
0.007828
0.027397
0
0.015656
0.027397
0.029354
0.015656
0.023483
0.043053
0.052838
0.001957
0.017613
0.023483
0.007828
0.033268
0.060665
0.062622
0.11546
0.056751
0.019569
0.046967
0.013699
0.031311
0.02544
0.037182
0.033268
0.09002
0.054795
0.009785
0.001957
0.013699
0
32,449
G
G
G
C
T
G
G
C
A
G
A
T
G
G
T
G
T
T
T
C
T
T
C
C
C
A
C
A
C
G
C
C
T
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T
T
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C
C
C
A
A
G
C
T
G
A
C
C
G
C
C
G
A
C
A
T
A
A
G
A
G
G
T
T
C
0.019569
0.019569
0.037182
0.013699
0.039139
0.02544
0.013699
0.013699
0.029354
0.056751
0.064579
0.013699
0.011742
0.011742
0.029354
0.041096
0.078278
0.066536
0.074364
0.019569
0.011742
0.009785
0.009785
0.037182
0.033268
0.023483
0.033268
0.082192
0.043053
0.007828
0.007828
0.021526
0
32,450
C
A
T
C
T
C
A
A
T
C
G
T
T
T
C
T
T
C
C
T
A
T
T
T
G
C
C
C
T
T
T
T
T
C
T
C
T
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G
T
T
T
G
G
T
G
A
G
A
T
G
T
G
G
C
T
T
T
C
C
A
C
T
C
A
C
0.052838
0.033268
0.039139
0.015656
0.033268
0.035225
0.015656
0.017613
0.02544
0.04501
0.050881
0.015656
0.029354
0.037182
0.033268
0.031311
0.043053
0.041096
0.046967
0.019569
0.021526
0.02544
0.02544
0.031311
0.043053
0.019569
0.029354
0.037182
0.037182
0.017613
0.011742
0.039139
0
32,451
C
G
G
T
G
T
G
T
G
C
C
A
G
G
G
T
G
C
A
G
T
G
G
G
T
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A
G
C
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C
C
T
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C
C
C
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G
G
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C
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G
C
G
G
C
T
G
G
G
C
C
T
G
C
G
T
G
T
A
C
C
0.009785
0.015656
0.015656
0
0.056751
0.041096
0.009785
0.019569
0.023483
0.056751
0.062622
0
0.003914
0.007828
0.015656
0.068493
0.093933
0.058708
0.064579
0.035225
0.011742
0.033268
0.005871
0.04501
0.013699
0.027397
0.052838
0.076321
0.039139
0.015656
0.001957
0.017613
0
32,452
G
G
C
G
G
T
G
T
G
T
G
C
C
A
G
G
G
T
G
C
A
G
T
G
G
G
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C
A
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C
T
C
C
T
G
C
C
C
A
G
G
G
C
C
C
G
G
C
G
G
C
T
G
G
G
C
C
T
G
C
G
T
G
T
G
0.009785
0.015656
0.015656
0
0.056751
0.041096
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0.023483
0.054795
0.064579
0
0.003914
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0.093933
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0.064579
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0.013699
0.027397
0.052838
0.076321
0.039139
0.015656
0.001957
0.017613
0
32,453
T
G
A
A
G
C
T
G
T
G
G
C
C
T
C
T
T
C
C
C
A
A
A
G
C
C
T
T
G
C
T
G
T
C
C
A
A
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A
A
C
A
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A
G
C
C
C
C
A
G
A
C
A
A
C
G
G
C
C
C
T
A
T
C
C
0.001957
0.011742
0.029354
0.007828
0.046967
0.031311
0.011742
0.013699
0.021526
0.062622
0.062622
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0.086106
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0.013699
0.035225
0.033268
0.084149
0.046967
0.003914
0.001957
0.027397
0
32,454
C
T
C
T
C
A
T
T
C
T
T
T
A
C
C
T
G
C
T
C
T
C
C
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T
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C
A
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G
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T
G
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G
C
A
G
G
A
A
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C
A
C
C
C
A
G
A
C
A
C
C
C
G
C
A
C
C
C
G
G
T
0.011742
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0.04501
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0.031311
0.019569
0.064579
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0.023483
0.023483
0.062622
0.054795
0.039139
0.009785
0.007828
0.035225
0
32,455
T
C
T
C
T
G
G
C
C
T
T
C
T
G
C
C
T
A
G
C
C
C
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C
A
C
C
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G
G
C
C
T
G
T
G
T
C
C
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A
G
C
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C
C
G
C
C
A
C
C
A
C
C
A
C
C
A
C
C
A
C
A
A
0.005871
0.005871
0.035225
0.001957
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0
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0.02544
0.043053
0.074364
0.041096
0.013699
0.003914
0.023483
0
32,456
C
G
G
G
G
C
C
T
G
C
A
A
A
G
C
C
C
C
T
G
G
G
G
G
A
C
A
G
G
T
A
G
C
G
G
G
C
G
G
G
G
G
C
T
G
T
G
G
C
A
A
T
G
T
G
G
T
G
C
C
T
G
G
C
T
T
0.005871
0.009785
0.033268
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0.019569
0.017613
0.019569
0.011742
0.015656
0.050881
0.074364
0
0.003914
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0.064579
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0.046967
0.027397
0.015656
0.041096
0.111546
0.060665
0.007828
0.005871
0.005871
0
32,457
C
G
A
A
G
A
C
T
T
C
C
C
C
A
G
C
C
T
C
T
C
T
G
C
C
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C
C
A
C
T
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C
C
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T
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C
T
C
C
A
C
T
G
C
A
G
C
A
A
C
C
C
C
G
G
G
C
C
A
0
0.007828
0.033268
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0.046967
0.007828
0.015656
0.021526
0.056751
0.068493
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0.080235
0.074364
0.09589
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0.009785
0.029354
0.007828
0.041096
0.027397
0.013699
0.056751
0.084149
0.043053
0.013699
0
0.011742
0
32,458
G
A
A
G
G
C
C
G
C
T
G
C
A
G
C
A
C
G
G
A
G
C
A
G
T
T
C
A
C
C
C
A
C
G
C
C
T
T
C
C
G
C
A
C
C
G
A
G
A
T
C
G
A
C
C
T
C
A
A
G
G
C
C
C
A
T
0.001957
0.009785
0.019569
0
0.019569
0.041096
0.019569
0.02544
0.02544
0.046967
0.060665
0.001957
0.013699
0.019569
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0.052838
0.076321
0.04501
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0.050881
0.031311
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0.046967
0.021526
0.031311
0.064579
0.078278
0.035225
0.011742
0.005871
0.021526
0
32,459
C
G
G
C
C
A
C
G
C
G
G
C
C
A
G
C
C
C
C
G
G
G
C
T
C
C
T
C
T
G
G
G
C
C
A
C
G
C
G
T
G
T
C
A
C
G
T
C
A
A
C
A
C
T
C
G
C
C
G
G
G
C
T
C
C
T
0.02544
0.021526
0.019569
0.021526
0.02544
0.029354
0.027397
0.017613
0.02544
0.035225
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0.021526
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0.02544
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0.037182
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0.043053
0.052838
0.078278
0.019569
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0.017613
0.029354
0.021526
0.093933
0.02544
0.013699
0.017613
0.029354
0
32,460
C
C
C
T
C
T
C
C
C
C
C
G
A
A
C
C
C
G
C
A
G
C
C
C
G
C
G
A
G
G
C
T
C
C
T
C
T
C
C
T
G
C
T
G
C
C
C
T
C
G
T
G
G
G
T
T
C
A
G
G
A
G
C
T
G
T
0
0.007828
0.009785
0
0.009785
0.02544
0.027397
0.007828
0.019569
0.064579
0.052838
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0.005871
0.003914
0.033268
0.066536
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0.099804
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0.107632
0.003914
0.064579
0.013699
0.021526
0.043053
0.09002
0.054795
0.009785
0
0.013699
0
32,461
G
A
T
C
C
C
T
G
C
C
T
G
G
G
A
G
C
T
C
C
T
G
C
G
T
C
G
C
G
T
C
T
C
C
C
A
C
A
G
C
T
C
C
T
G
A
A
C
C
C
A
C
G
A
G
G
G
C
A
G
C
A
G
G
A
G
0.001957
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0.013699
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0.023483
0.064579
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0.031311
0.07045
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0.015656
0.103718
0.003914
0.062622
0.019569
0.021526
0.046967
0.084149
0.056751
0.009785
0
0.013699
0
32,462
G
G
C
A
G
G
G
C
A
G
G
C
C
A
A
G
G
C
G
G
T
T
T
G
C
T
G
C
G
G
G
G
T
C
C
A
C
C
G
C
T
G
G
G
C
G
G
G
A
G
A
C
G
T
C
T
C
T
C
C
G
A
A
G
T
G
0.009785
0.011742
0.021526
0.005871
0.013699
0.033268
0.029354
0.007828
0.033268
0.035225
0.064579
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0.001957
0.007828
0.015656
0.02544
0.054795
0.037182
0.09589
0.068493
0.015656
0.082192
0.007828
0.054795
0.019569
0.039139
0.037182
0.088063
0.048924
0.007828
0.003914
0.017613
0
32,463
G
T
C
T
T
C
C
T
G
T
G
T
G
G
A
C
T
C
C
C
T
C
T
G
G
A
G
C
G
T
G
G
C
C
C
A
G
G
C
C
C
T
G
T
T
G
G
T
G
C
T
G
T
G
C
C
C
T
G
G
G
A
C
T
G
T
0.001957
0.007828
0.015656
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0.035225
0.031311
0.023483
0.017613
0.027397
0.074364
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0.005871
0.009785
0.011742
0.048924
0.088063
0.068493
0.07045
0.029354
0.013699
0.046967
0.017613
0.050881
0.009785
0.027397
0.039139
0.084149
0.037182
0.023483
0.005871
0.015656
0
32,464
G
C
C
C
T
C
C
C
C
G
G
C
C
G
C
G
C
A
G
T
C
A
C
C
T
A
C
C
A
G
G
A
T
G
G
C
C
A
G
C
T
G
G
G
C
G
T
A
G
G
C
T
A
C
C
C
C
G
A
G
C
A
C
C
A
C
0.007828
0.001957
0.021526
0.003914
0.033268
0.033268
0.021526
0.013699
0.027397
0.074364
0.052838
0.001957
0.003914
0.005871
0.013699
0.052838
0.09002
0.064579
0.080235
0.033268
0.015656
0.046967
0.013699
0.04501
0.009785
0.031311
0.046967
0.086106
0.029354
0.015656
0.003914
0.017613
0
32,465
C
A
G
C
A
C
T
C
C
T
G
G
G
G
A
G
A
A
G
A
C
A
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A
G
A
C
G
C
T
G
G
C
G
C
T
G
C
A
G
A
G
G
C
T
G
G
G
G
G
A
G
C
T
G
G
G
G
C
C
A
C
C
C
A
T
0.009785
0.015656
0.021526
0.003914
0.031311
0.033268
0.011742
0.017613
0.029354
0.062622
0.068493
0
0.003914
0.011742
0.015656
0.039139
0.093933
0.068493
0.084149
0.027397
0.007828
0.023483
0.009785
0.050881
0.021526
0.033268
0.041096
0.080235
0.052838
0.005871
0.003914
0.019569
0
32,466
T
C
T
C
C
G
T
G
A
T
G
T
T
C
T
T
G
C
G
T
A
T
C
T
G
G
G
C
T
C
G
G
T
G
C
T
G
C
C
G
C
T
C
G
T
G
C
T
T
G
G
G
C
T
C
T
G
C
C
G
C
C
A
C
G
C
0.007828
0.013699
0.017613
0.001957
0.029354
0.023483
0.023483
0.017613
0.02544
0.064579
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0.033268
0.013699
0.04501
0.09589
0.056751
0.078278
0.029354
0.013699
0.027397
0.005871
0.039139
0.015656
0.023483
0.076321
0.078278
0.033268
0.011742
0.003914
0.02544
0
32,467
A
G
A
G
G
C
A
G
T
T
T
G
T
G
C
A
G
C
T
C
G
G
G
G
A
C
G
A
G
G
C
C
T
G
G
C
T
G
G
T
G
G
C
A
T
G
T
G
C
C
T
G
G
C
C
C
C
C
G
T
T
C
C
C
C
C
0.003914
0.021526
0.017613
0.005871
0.02544
0.048924
0.039139
0.015656
0.019569
0.048924
0.048924
0.001957
0.011742
0.019569
0.023483
0.060665
0.064579
0.058708
0.068493
0.043053
0.017613
0.029354
0.011742
0.039139
0.019569
0.035225
0.050881
0.066536
0.037182
0.011742
0.001957
0.031311
0
32,468
G
G
T
G
G
C
C
C
A
G
G
T
G
C
T
G
G
T
G
G
A
G
C
A
C
A
A
T
G
T
C
A
T
G
C
A
C
A
C
C
T
A
C
G
C
T
G
C
C
C
C
A
G
G
T
G
A
G
G
G
A
T
G
A
G
C
0.003914
0.011742
0.017613
0.003914
0.017613
0.043053
0.013699
0.023483
0.007828
0.04501
0.068493
0
0.005871
0.013699
0.013699
0.054795
0.07045
0.062622
0.150685
0.039139
0.005871
0.019569
0.005871
0.050881
0.017613
0.023483
0.037182
0.078278
0.048924
0.007828
0.001957
0.035225
0
32,469
G
C
C
G
G
C
A
G
G
G
G
G
G
A
G
T
C
A
C
G
C
G
C
G
G
G
C
G
C
C
A
C
T
C
T
G
C
C
G
C
A
G
G
G
G
C
G
G
G
C
T
G
C
G
C
G
T
G
C
G
C
A
A
G
G
G
0.009785
0.005871
0.029354
0.007828
0.015656
0.021526
0.029354
0.015656
0.021526
0.050881
0.043053
0.007828
0.011742
0.017613
0.009785
0.037182
0.052838
0.041096
0.093933
0.068493
0.007828
0.09002
0.013699
0.035225
0.021526
0.021526
0.04501
0.084149
0.04501
0.017613
0.011742
0.015656
0
32,470
C
T
G
A
G
C
A
G
A
G
C
C
A
A
G
A
A
G
C
C
C
T
C
C
A
G
C
C
A
C
A
A
C
C
C
C
C
A
C
A
G
C
G
G
C
C
A
G
C
A
C
C
A
G
C
A
G
C
A
G
C
A
G
C
A
T
0.003914
0.009785
0.031311
0
0.023483
0.041096
0.005871
0.013699
0.021526
0.082192
0.078278
0.003914
0.005871
0.013699
0.019569
0.046967
0.099804
0.062622
0.099804
0.009785
0
0.011742
0.007828
0.056751
0.015656
0.023483
0.064579
0.058708
0.050881
0.003914
0.003914
0.029354
0
32,471
C
A
G
C
A
C
C
A
G
C
A
G
C
A
G
C
A
G
C
A
G
C
A
G
G
A
G
C
A
G
G
C
T
C
A
C
G
G
C
T
C
T
C
C
A
G
C
C
C
C
C
G
C
A
G
G
A
G
G
G
C
T
T
G
G
C
0.003914
0.009785
0.031311
0.003914
0.02544
0.041096
0.005871
0.011742
0.021526
0.074364
0.078278
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0.009785
0.017613
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0.046967
0.091977
0.060665
0.097847
0.011742
0.001957
0.011742
0.007828
0.054795
0.017613
0.023483
0.062622
0.058708
0.050881
0.003914
0.003914
0.031311
0
32,472
A
C
C
C
A
C
C
T
C
T
G
C
C
T
T
G
A
C
G
G
C
C
G
C
G
C
A
C
C
C
C
T
T
A
G
G
A
A
G
T
G
G
C
T
G
T
C
C
A
G
C
G
C
C
T
G
C
C
T
G
T
G
C
T
G
C
0.011742
0.017613
0.027397
0.001957
0.031311
0.037182
0.007828
0.005871
0.031311
0.050881
0.088063
0.003914
0.02544
0.019569
0.023483
0.037182
0.09002
0.066536
0.076321
0.009785
0.007828
0.017613
0.007828
0.050881
0.015656
0.02544
0.041096
0.080235
0.046967
0.001957
0.009785
0.031311
0
32,473
C
A
C
C
C
A
G
G
C
G
C
A
G
T
C
G
C
T
C
T
G
G
A
T
C
C
T
C
C
C
A
A
C
C
T
A
A
A
G
C
T
A
A
A
T
C
T
A
G
A
A
C
G
C
C
A
C
C
C
A
G
A
C
G
C
A
0.052838
0.02544
0.050881
0.029354
0.029354
0.033268
0.009785
0.017613
0.078278
0.029354
0.041096
0.001957
0.037182
0.02544
0.039139
0.02544
0.048924
0.04501
0.027397
0.011742
0.009785
0.027397
0.023483
0.043053
0.050881
0.037182
0.021526
0.027397
0.037182
0.001957
0.015656
0.04501
0
32,474
G
C
G
C
G
C
G
G
A
C
T
C
C
A
C
T
C
C
G
C
C
C
G
C
C
A
C
C
A
G
C
G
C
G
T
G
A
A
T
T
T
C
C
C
G
G
T
G
G
C
C
G
C
A
G
G
C
C
T
C
T
G
G
G
A
A
0.009785
0.009785
0.015656
0.007828
0.007828
0.033268
0.021526
0.021526
0.021526
0.052838
0.04501
0
0.007828
0.015656
0.013699
0.043053
0.064579
0.066536
0.088063
0.058708
0.005871
0.074364
0.013699
0.048924
0.013699
0.027397
0.041096
0.09002
0.046967
0.003914
0.005871
0.023483
0
32,475
C
T
C
T
A
G
C
C
G
T
A
G
T
A
T
G
A
T
C
T
G
G
G
A
T
T
C
C
A
T
G
T
T
T
T
G
T
G
C
T
G
G
T
G
C
T
G
A
G
G
A
T
G
G
C
A
G
T
G
T
A
G
A
C
A
G
0.035225
0.029354
0.023483
0.02544
0.04501
0.052838
0.001957
0.021526
0.048924
0.039139
0.058708
0.015656
0.019569
0.02544
0.027397
0.052838
0.058708
0.048924
0.054795
0.005871
0
0
0.027397
0.058708
0.027397
0.015656
0.043053
0.019569
0.043053
0.023483
0.023483
0.027397
0