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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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C
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4,348
A
T
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1
4,349
T
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G
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G
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1
4,350
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1
4,351
C
A
C
A
C
A
C
C
T
C
A
C
C
C
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A
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C
A
A
G
G
G
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C
C
T
T
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1
4,352
C
A
C
A
C
A
C
C
T
C
A
C
C
C
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C
G
A
T
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T
T
A
C
C
A
A
G
G
G
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T
T
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G
G
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T
C
A
C
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C
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C
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T
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1
4,353
T
T
G
A
C
T
A
C
C
T
G
C
G
C
T
T
C
C
T
G
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A
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G
C
G
C
T
T
T
C
G
C
C
A
C
C
A
T
C
T
G
G
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1
4,354
C
C
A
G
A
T
G
G
T
G
G
C
G
A
A
A
G
C
G
C
T
T
C
T
G
C
A
G
G
A
A
G
C
G
C
A
G
G
T
A
G
T
C
A
A
A
A
T
C
A
C
A
G
G
C
A
A
A
G
T
A
G
C
T
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T
0.101761
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1
4,355
G
G
G
A
G
T
C
C
T
T
C
T
G
C
C
C
A
A
G
A
T
G
A
A
G
C
C
T
C
T
C
C
T
C
T
A
T
C
A
G
A
A
T
G
G
A
G
G
G
C
C
A
G
T
T
A
T
A
A
C
A
G
T
G
C
C
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1
4,356
T
G
T
G
T
T
A
A
A
C
T
T
T
T
C
T
T
G
T
T
T
T
C
C
A
G
A
T
T
A
C
C
T
G
G
C
A
G
C
T
G
T
G
G
A
C
A
A
G
T
G
G
T
T
G
G
G
A
G
T
C
C
T
T
C
G
0.046967
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1
4,357
T
T
C
T
C
A
A
G
A
C
A
T
C
T
G
T
A
A
C
A
A
C
C
T
A
C
C
T
G
G
G
T
C
G
G
A
G
G
A
G
C
G
G
A
G
A
A
G
A
A
T
A
G
A
C
T
C
T
T
T
C
T
C
T
A
A
0.058708
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1
4,358
C
A
C
C
A
T
T
T
C
C
C
A
C
T
C
T
G
C
A
C
A
G
A
T
G
T
A
G
G
G
C
C
C
G
G
G
C
C
T
C
A
G
G
A
T
A
A
C
C
A
G
C
A
G
T
C
C
C
A
G
C
T
C
A
T
T
0.035225
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1
4,359
C
C
T
G
G
C
C
A
G
G
A
C
A
G
T
A
C
C
A
G
T
T
T
T
C
T
G
A
G
G
A
C
C
A
T
G
A
T
G
T
G
G
A
A
T
A
T
T
T
T
C
T
T
C
G
G
C
T
G
G
C
T
C
A
T
G
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1
4,360
C
A
G
A
A
A
A
C
T
G
G
T
A
C
T
G
T
C
C
T
G
G
C
C
A
G
G
G
C
T
C
A
T
G
A
A
A
G
T
T
C
C
A
G
G
G
C
A
C
A
T
A
C
C
T
G
C
C
A
A
G
A
C
A
C
A
0.035225
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0.031311
1
4,361
A
T
C
C
A
G
G
A
A
G
G
G
G
C
T
G
T
G
T
G
T
G
T
C
T
T
G
G
C
A
G
G
T
A
T
G
T
G
C
C
C
T
G
G
A
A
C
T
T
T
C
A
T
G
A
G
C
C
C
T
G
G
C
C
A
C
0.037182
0.013699
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0.033268
1
4,362
A
C
T
C
C
C
G
T
G
T
G
C
C
C
C
G
C
T
T
C
T
A
C
T
G
G
A
A
G
G
A
C
C
G
G
C
T
G
C
T
G
A
A
G
A
T
G
A
A
G
A
T
G
G
C
T
G
G
G
C
T
G
A
A
C
T
0.037182
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0.019569
0.02544
0.041096
0.041096
0.021526
0.019569
0.052838
1
4,363
C
T
T
C
C
T
C
A
A
G
G
A
T
G
G
C
C
A
G
C
C
A
T
T
T
C
G
C
T
A
C
A
T
C
T
C
A
G
G
A
A
G
C
A
T
T
C
A
C
T
A
C
T
C
C
C
G
T
G
T
G
C
C
C
C
C
0.033268
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0.033268
0.031311
0.023483
0.007828
0.031311
0.04501
0.04501
0.039139
0.021526
0.02544
0.048924
0.027397
0.031311
0.048924
0.050881
0.035225
0.017613
0.003914
0.005871
0.027397
0.04501
0.048924
0.021526
0.027397
0.043053
0.041096
0.02544
0.011742
0.046967
1
4,364
G
C
A
C
A
C
G
G
G
A
G
T
A
G
T
G
A
A
T
G
C
T
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G
G
C
C
A
T
C
C
T
T
G
A
G
G
A
A
G
G
A
G
C
0.029354
0.015656
0.039139
0.033268
0.031311
0.023483
0.007828
0.031311
0.04501
0.04501
0.041096
0.021526
0.02544
0.048924
0.027397
0.031311
0.050881
0.050881
0.035225
0.017613
0.003914
0.005871
0.027397
0.04501
0.046967
0.021526
0.027397
0.043053
0.041096
0.02544
0.011742
0.048924
1
4,365
G
C
T
G
G
C
C
A
T
C
C
T
T
G
A
G
G
A
A
G
G
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A
C
A
T
C
C
T
C
T
G
G
G
T
G
G
C
A
T
T
C
C
0.029354
0.013699
0.039139
0.037182
0.029354
0.02544
0.007828
0.029354
0.050881
0.041096
0.041096
0.023483
0.033268
0.050881
0.02544
0.031311
0.048924
0.050881
0.027397
0.013699
0.003914
0.005871
0.029354
0.04501
0.048924
0.017613
0.031311
0.035225
0.04501
0.027397
0.015656
0.04501
1
4,366
C
G
G
G
G
C
C
T
G
G
G
A
C
G
G
G
G
C
G
A
G
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A
C
T
G
C
A
G
G
A
A
C
T
T
G
T
A
G
G
G
C
C
0.007828
0.015656
0.039139
0.003914
0.011742
0.017613
0.009785
0.02544
0.029354
0.052838
0.062622
0.003914
0.007828
0.007828
0.023483
0.011742
0.072407
0.035225
0.068493
0.050881
0.019569
0.09002
0.019569
0.039139
0.029354
0.019569
0.054795
0.099804
0.033268
0.017613
0.005871
0.013699
1
4,367
C
A
G
C
C
G
C
C
G
A
A
T
A
A
C
C
C
C
T
G
C
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A
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A
G
C
C
A
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G
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A
C
G
T
C
T
A
G
C
0.013699
0.027397
0.037182
0.021526
0.017613
0.019569
0.035225
0.023483
0.031311
0.054795
0.033268
0.011742
0.019569
0.02544
0.031311
0.027397
0.04501
0.037182
0.043053
0.04501
0.019569
0.052838
0.023483
0.039139
0.037182
0.023483
0.035225
0.064579
0.031311
0.017613
0.017613
0.037182
1
4,368
C
A
G
C
C
G
C
C
G
A
A
T
A
A
C
C
C
C
T
G
C
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G
C
C
A
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G
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A
C
G
T
C
T
A
G
A
0.013699
0.027397
0.037182
0.021526
0.017613
0.019569
0.035225
0.023483
0.031311
0.054795
0.033268
0.011742
0.019569
0.02544
0.031311
0.027397
0.04501
0.037182
0.043053
0.04501
0.019569
0.052838
0.023483
0.039139
0.037182
0.023483
0.035225
0.064579
0.031311
0.017613
0.017613
0.037182
1
4,369
T
A
G
A
C
G
T
T
T
C
C
T
T
G
G
C
T
C
T
T
C
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G
G
C
T
G
G
A
0.013699
0.027397
0.037182
0.021526
0.017613
0.019569
0.035225
0.023483
0.031311
0.054795
0.033268
0.011742
0.019569
0.02544
0.031311
0.027397
0.04501
0.037182
0.043053
0.04501
0.019569
0.052838
0.021526
0.039139
0.037182
0.023483
0.035225
0.064579
0.031311
0.017613
0.017613
0.039139
1
4,370
T
A
G
A
C
G
T
T
T
C
C
T
T
G
G
C
T
C
T
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C
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A
G
G
G
G
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T
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T
T
C
G
G
C
G
G
C
T
G
G
C
0.013699
0.027397
0.037182
0.021526
0.017613
0.019569
0.035225
0.023483
0.031311
0.054795
0.033268
0.011742
0.019569
0.02544
0.031311
0.027397
0.04501
0.037182
0.043053
0.04501
0.019569
0.052838
0.021526
0.039139
0.037182
0.023483
0.035225
0.064579
0.031311
0.017613
0.017613
0.039139
1
4,371
T
A
G
A
C
G
T
T
T
C
C
T
T
G
G
C
T
C
T
T
C
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A
G
G
G
G
T
T
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T
T
C
G
G
C
G
G
C
T
G
G
G
0.013699
0.027397
0.037182
0.021526
0.017613
0.019569
0.035225
0.023483
0.031311
0.054795
0.033268
0.011742
0.019569
0.02544
0.031311
0.027397
0.04501
0.037182
0.043053
0.04501
0.019569
0.052838
0.021526
0.039139
0.037182
0.023483
0.035225
0.064579
0.031311
0.017613
0.017613
0.039139
1
4,372
T
C
C
A
G
C
C
G
C
C
G
A
A
T
A
A
C
C
C
C
T
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C
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A
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A
C
G
T
C
T
T
0.013699
0.027397
0.037182
0.021526
0.017613
0.019569
0.035225
0.023483
0.031311
0.054795
0.033268
0.011742
0.019569
0.02544
0.031311
0.027397
0.04501
0.037182
0.043053
0.04501
0.019569
0.052838
0.021526
0.039139
0.037182
0.02544
0.035225
0.064579
0.031311
0.017613
0.015656
0.039139
1
4,373
A
G
C
T
G
G
C
C
G
C
T
G
G
A
T
A
A
C
T
T
C
C
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C
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C
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G
A
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C
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T
G
T
C
T
C
G
T
C
C
A
G
C
C
G
C
C
G
A
A
A
0.021526
0.027397
0.037182
0.021526
0.021526
0.021526
0.039139
0.023483
0.035225
0.048924
0.031311
0.007828
0.017613
0.023483
0.029354
0.033268
0.046967
0.039139
0.037182
0.046967
0.019569
0.043053
0.013699
0.041096
0.039139
0.029354
0.033268
0.066536
0.031311
0.015656
0.017613
0.039139
1
4,374
G
C
T
G
G
A
C
G
A
G
A
C
A
G
T
G
G
T
G
A
A
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C
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C
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C
G
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T
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C
C
A
G
C
G
G
C
C
A
G
C
T
A
A
T
G
C
T
A
A
0.021526
0.027397
0.035225
0.021526
0.021526
0.021526
0.037182
0.023483
0.035225
0.048924
0.031311
0.007828
0.017613
0.023483
0.029354
0.033268
0.046967
0.039139
0.043053
0.048924
0.017613
0.043053
0.013699
0.043053
0.037182
0.027397
0.033268
0.066536
0.031311
0.015656
0.017613
0.039139
1
4,375
G
C
T
G
G
A
C
G
A
G
A
C
A
G
T
G
G
T
G
A
A
C
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C
A
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C
G
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A
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T
T
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T
C
C
A
G
C
G
G
C
C
A
G
C
T
A
A
T
G
C
T
A
T
0.021526
0.027397
0.035225
0.021526
0.021526
0.021526
0.037182
0.023483
0.035225
0.048924
0.031311
0.007828
0.017613
0.023483
0.029354
0.033268
0.046967
0.039139
0.043053
0.048924
0.017613
0.043053
0.013699
0.043053
0.037182
0.027397
0.033268
0.066536
0.031311
0.015656
0.017613
0.039139
1
4,376
C
C
G
C
A
T
C
G
C
G
G
C
G
G
G
G
G
A
A
G
T
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C
C
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C
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C
T
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C
A
A
A
G
A
G
A
T
G
A
T
T
G
A
G
A
A
C
T
T
0.027397
0.027397
0.039139
0.021526
0.021526
0.021526
0.037182
0.021526
0.033268
0.046967
0.035225
0.007828
0.017613
0.023483
0.031311
0.031311
0.043053
0.035225
0.041096
0.048924
0.019569
0.043053
0.013699
0.041096
0.037182
0.027397
0.031311
0.066536
0.031311
0.015656
0.021526
0.039139
1
4,377
C
A
T
C
G
C
G
G
C
G
G
G
G
G
A
A
G
T
T
A
T
C
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C
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C
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A
G
A
G
A
T
G
A
T
T
G
A
G
A
A
C
T
G
G
T
G
0.027397
0.027397
0.039139
0.021526
0.021526
0.021526
0.037182
0.021526
0.033268
0.046967
0.035225
0.007828
0.017613
0.023483
0.029354
0.031311
0.043053
0.037182
0.041096
0.048924
0.019569
0.043053
0.013699
0.041096
0.037182
0.027397
0.031311
0.066536
0.033268
0.015656
0.021526
0.037182
1
4,378
T
A
T
C
C
A
G
C
G
G
C
C
A
G
C
T
A
A
T
G
C
T
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G
T
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C
G
G
A
G
G
G
A
G
T
C
G
A
G
C
C
G
G
0.023483
0.027397
0.041096
0.017613
0.023483
0.021526
0.037182
0.023483
0.031311
0.046967
0.037182
0.013699
0.017613
0.021526
0.027397
0.035225
0.041096
0.037182
0.041096
0.048924
0.019569
0.043053
0.013699
0.043053
0.035225
0.02544
0.029354
0.064579
0.037182
0.017613
0.023483
0.033268
1
4,379
A
G
T
G
A
G
C
C
C
G
G
C
T
C
G
A
C
T
C
C
C
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C
C
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T
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C
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T
T
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C
A
A
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A
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C
T
T
T
G
A
T
A
G
C
A
T
T
A
G
C
T
G
G
C
C
G
0.023483
0.027397
0.039139
0.017613
0.023483
0.021526
0.041096
0.02544
0.031311
0.043053
0.037182
0.013699
0.017613
0.021526
0.02544
0.037182
0.039139
0.037182
0.041096
0.048924
0.019569
0.043053
0.015656
0.043053
0.035225
0.023483
0.029354
0.064579
0.035225
0.021526
0.023483
0.033268
1
4,380
A
A
G
T
G
A
G
C
C
C
G
G
C
T
C
G
A
C
T
C
C
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C
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T
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C
T
T
T
G
A
T
A
G
C
A
T
T
A
G
C
T
G
G
C
C
0.023483
0.029354
0.039139
0.017613
0.023483
0.021526
0.041096
0.02544
0.031311
0.043053
0.037182
0.013699
0.017613
0.021526
0.02544
0.037182
0.039139
0.035225
0.041096
0.048924
0.019569
0.043053
0.015656
0.043053
0.035225
0.023483
0.029354
0.064579
0.035225
0.021526
0.023483
0.033268
1
4,381
C
C
A
G
C
T
A
A
T
G
C
T
A
T
C
A
A
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A
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A
G
T
C
G
A
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G
G
C
T
C
A
C
T
T
A
G
0.023483
0.029354
0.039139
0.017613
0.023483
0.021526
0.041096
0.02544
0.031311
0.043053
0.037182
0.013699
0.017613
0.021526
0.02544
0.037182
0.039139
0.035225
0.041096
0.048924
0.019569
0.043053
0.015656
0.043053
0.035225
0.023483
0.029354
0.064579
0.035225
0.021526
0.023483
0.033268
1
4,382
A
A
C
A
A
T
C
A
C
T
T
G
A
A
T
A
C
T
T
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T
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T
C
A
A
A
C
A
G
A
A
A
A
T
A
A
T
T
T
A
T
G
0.078278
0.039139
0.031311
0.058708
0.050881
0.013699
0.005871
0.037182
0.04501
0.017613
0.035225
0.043053
0.029354
0.033268
0.052838
0.02544
0.041096
0.023483
0.017613
0.005871
0
0.003914
0.02544
0.037182
0.039139
0.015656
0.033268
0.019569
0.029354
0.027397
0.037182
0.046967
1
4,383
T
A
A
C
A
A
T
C
A
C
T
T
G
A
A
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T
C
A
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A
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A
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A
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T
A
A
T
T
T
A
C
0.078278
0.039139
0.031311
0.058708
0.048924
0.013699
0.005871
0.037182
0.04501
0.017613
0.035225
0.043053
0.029354
0.033268
0.052838
0.02544
0.041096
0.023483
0.017613
0.005871
0
0.003914
0.02544
0.037182
0.039139
0.015656
0.033268
0.019569
0.031311
0.027397
0.037182
0.046967
1
4,384
T
A
A
C
A
A
T
C
A
C
T
T
G
A
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A
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A
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A
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0.078278
0.039139
0.031311
0.058708
0.048924
0.013699
0.005871
0.037182
0.04501
0.017613
0.035225
0.043053
0.029354
0.033268
0.052838
0.02544
0.041096
0.023483
0.017613
0.005871
0
0.003914
0.02544
0.037182
0.039139
0.015656
0.033268
0.019569
0.031311
0.027397
0.037182
0.046967
1
4,385
T
T
C
T
G
T
T
T
G
A
T
T
T
G
C
C
A
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G
A
T
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T
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A
A
A
G
A
G
G
G
A
G
T
0.076321
0.039139
0.029354
0.058708
0.052838
0.013699
0.005871
0.039139
0.043053
0.017613
0.033268
0.043053
0.031311
0.035225
0.052838
0.027397
0.043053
0.023483
0.017613
0.005871
0
0.003914
0.021526
0.037182
0.037182
0.015656
0.033268
0.019569
0.029354
0.027397
0.037182
0.048924
1
4,386
C
A
G
T
T
T
A
G
A
T
G
C
A
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A
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C
C
T
G
A
A
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T
T
G
A
T
T
C
A
0.078278
0.037182
0.029354
0.062622
0.050881
0.013699
0.005871
0.037182
0.041096
0.017613
0.031311
0.04501
0.033268
0.035225
0.052838
0.029354
0.041096
0.023483
0.017613
0.005871
0
0.003914
0.021526
0.035225
0.035225
0.015656
0.033268
0.019569
0.027397
0.027397
0.041096
0.050881
1
4,387
G
A
G
G
G
A
G
G
C
C
T
G
A
A
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T
T
G
A
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A
T
C
A
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G
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A
A
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T
A
A
A
A
C
C
T
C
A
0.080235
0.035225
0.033268
0.062622
0.050881
0.013699
0.003914
0.039139
0.043053
0.015656
0.029354
0.048924
0.035225
0.033268
0.050881
0.031311
0.039139
0.02544
0.017613
0.003914
0
0.003914
0.021526
0.035225
0.035225
0.013699
0.029354
0.017613
0.027397
0.029354
0.04501
0.048924
1
4,388
C
T
G
C
T
A
C
T
T
T
G
A
G
G
T
T
T
T
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T
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G
A
T
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T
G
A
A
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C
A
A
C
T
T
C
A
T
0.084149
0.035225
0.031311
0.064579
0.052838
0.015656
0.003914
0.039139
0.039139
0.015656
0.027397
0.048924
0.035225
0.035225
0.052838
0.031311
0.039139
0.027397
0.017613
0.003914
0
0.003914
0.021526
0.029354
0.033268
0.013699
0.029354
0.017613
0.02544
0.031311
0.04501
0.048924
1
4,389
C
T
G
C
T
A
C
T
T
T
G
A
G
G
T
T
T
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G
A
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A
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A
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C
T
T
C
A
G
0.084149
0.035225
0.031311
0.064579
0.052838
0.015656
0.003914
0.039139
0.039139
0.015656
0.027397
0.048924
0.035225
0.035225
0.052838
0.031311
0.039139
0.027397
0.017613
0.003914
0
0.003914
0.021526
0.029354
0.033268
0.013699
0.029354
0.017613
0.02544
0.031311
0.04501
0.048924
1
4,390
C
T
G
C
T
A
C
T
T
T
G
A
G
G
T
T
T
T
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G
A
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G
A
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C
A
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C
T
T
C
A
A
0.084149
0.035225
0.031311
0.064579
0.052838
0.015656
0.003914
0.039139
0.039139
0.015656
0.027397
0.048924
0.035225
0.035225
0.052838
0.031311
0.039139
0.027397
0.017613
0.003914
0
0.003914
0.021526
0.029354
0.033268
0.013699
0.029354
0.017613
0.02544
0.031311
0.04501
0.048924
1
4,391
C
C
T
G
C
T
A
C
T
T
T
G
A
G
G
T
T
T
T
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T
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G
A
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T
G
A
A
T
C
A
A
C
T
T
C
T
0.084149
0.035225
0.031311
0.064579
0.052838
0.015656
0.003914
0.039139
0.037182
0.015656
0.027397
0.050881
0.035225
0.035225
0.052838
0.031311
0.039139
0.027397
0.017613
0.003914
0
0.003914
0.021526
0.029354
0.033268
0.013699
0.029354
0.017613
0.02544
0.031311
0.04501
0.048924
1
4,392
G
T
A
T
C
T
A
A
C
A
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A
A
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A
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A
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C
T
A
C
T
A
G
T
A
A
A
C
T
G
C
A
G
T
C
C
C
0.131115
0.031311
0.050881
0.048924
0.039139
0.021526
0
0.039139
0.062622
0.017613
0.029354
0.031311
0.035225
0.033268
0.04501
0.017613
0.035225
0.021526
0.003914
0
0.005871
0.001957
0.021526
0.041096
0.043053
0.019569
0.019569
0.007828
0.021526
0.031311
0.043053
0.048924
1
4,393
A
G
G
A
C
T
G
C
A
G
T
T
T
A
C
T
A
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A
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C
T
T
C
T
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T
T
A
G
A
T
A
T
0.131115
0.031311
0.050881
0.048924
0.039139
0.021526
0
0.039139
0.062622
0.017613
0.029354
0.031311
0.035225
0.033268
0.043053
0.017613
0.035225
0.021526
0.003914
0
0.005871
0.001957
0.021526
0.041096
0.043053
0.019569
0.019569
0.007828
0.021526
0.031311
0.04501
0.048924
1
4,394
A
G
A
T
C
T
G
G
A
T
A
T
T
G
T
A
T
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T
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G
T
C
C
T
T
T
G
A
G
G
A
T
T
T
A
G
C
C
A
T
0.136986
0.033268
0.046967
0.052838
0.037182
0.023483
0
0.039139
0.056751
0.017613
0.029354
0.035225
0.035225
0.033268
0.041096
0.017613
0.033268
0.021526
0.003914
0
0.005871
0.001957
0.023483
0.037182
0.043053
0.015656
0.019569
0.007828
0.021526
0.033268
0.048924
0.046967
1
4,395
C
A
C
A
T
T
T
C
T
T
G
A
A
T
C
T
T
T
A
G
C
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T
A
G
A
A
A
T
A
C
T
G
G
C
T
A
A
A
T
C
C
G
0.138943
0.033268
0.048924
0.052838
0.037182
0.027397
0
0.037182
0.058708
0.009785
0.029354
0.04501
0.035225
0.039139
0.041096
0.011742
0.029354
0.023483
0.003914
0
0.003914
0
0.02544
0.031311
0.04501
0.015656
0.015656
0.003914
0.021526
0.041096
0.048924
0.04501
1
4,396
T
A
T
T
T
T
A
C
A
C
A
T
T
T
C
T
T
G
A
A
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C
C
A
T
A
G
G
T
A
G
A
A
A
T
A
C
T
G
G
C
G
0.142857
0.035225
0.048924
0.052838
0.037182
0.027397
0
0.037182
0.056751
0.009785
0.029354
0.04501
0.035225
0.039139
0.039139
0.011742
0.029354
0.023483
0.003914
0
0.003914
0
0.02544
0.029354
0.048924
0.013699
0.013699
0.003914
0.021526
0.041096
0.048924
0.04501
1
4,397
A
T
T
T
T
C
T
T
T
T
C
T
T
C
C
T
T
A
G
G
C
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C
A
T
G
T
T
A
C
T
A
T
T
A
C
A
A
C
G
A
G
0.093933
0.027397
0.048924
0.048924
0.041096
0.019569
0.007828
0.039139
0.041096
0.027397
0.02544
0.052838
0.035225
0.04501
0.039139
0.035225
0.035225
0.029354
0.005871
0
0.003914
0
0.019569
0.027397
0.043053
0.015656
0.027397
0.015656
0.019569
0.029354
0.043053
0.056751
1
4,398
C
A
T
A
A
G
C
C
A
T
G
T
G
G
C
T
C
A
T
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T
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T
G
G
A
A
A
G
T
G
T
G
C
A
T
A
C
A
G
G
T
T
0.086106
0.02544
0.052838
0.048924
0.039139
0.017613
0.007828
0.039139
0.043053
0.027397
0.02544
0.060665
0.039139
0.046967
0.037182
0.033268
0.035225
0.02544
0.005871
0
0.003914
0
0.019569
0.027397
0.043053
0.013699
0.027397
0.015656
0.017613
0.031311
0.04501
0.058708
1
4,399
A
T
A
T
A
T
A
T
G
A
G
T
A
A
A
A
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A
A
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T
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C
C
A
T
C
A
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C
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T
T
T
T
C
G
T
T
T
0.080235
0.02544
0.052838
0.041096
0.041096
0.021526
0.011742
0.035225
0.043053
0.029354
0.031311
0.054795
0.039139
0.04501
0.037182
0.035225
0.037182
0.02544
0.005871
0
0.003914
0
0.021526
0.027397
0.039139
0.015656
0.031311
0.017613
0.017613
0.033268
0.043053
0.056751
1
4,400
A
G
G
G
G
C
T
T
T
C
A
G
T
T
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T
C
C
A
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T
A
T
A
A
C
A
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A
T
T
A
A
T
A
T
C
C
A
G
0.101761
0.02544
0.033268
0.082192
0.023483
0.013699
0.003914
0.027397
0.04501
0.029354
0.019569
0.072407
0.037182
0.035225
0.050881
0.013699
0.023483
0.041096
0.021526
0.003914
0
0
0.027397
0.037182
0.031311
0.007828
0.02544
0.017613
0.035225
0.021526
0.058708
0.033268
1
4,401
G
A
A
A
A
A
T
C
A
A
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T
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C
A
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A
G
C
T
T
G
0.088063
0.031311
0.04501
0.050881
0.041096
0.021526
0.001957
0.039139
0.048924
0.033268
0.02544
0.02544
0.027397
0.029354
0.043053
0.029354
0.046967
0.043053
0.02544
0
0.003914
0.001957
0.029354
0.027397
0.048924
0.021526
0.023483
0.015656
0.031311
0.021526
0.037182
0.041096
1
4,402
C
A
G
A
G
A
C
C
C
A
C
T
C
C
C
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A
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A
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T
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A
T
A
T
T
C
T
T
C
0.09589
0.035225
0.048924
0.041096
0.037182
0.023483
0.001957
0.041096
0.058708
0.039139
0.019569
0.02544
0.029354
0.02544
0.050881
0.023483
0.043053
0.04501
0.017613
0
0.003914
0.001957
0.031311
0.035225
0.039139
0.023483
0.021526
0.015656
0.02544
0.021526
0.039139
0.039139
1
4,403
T
C
A
G
A
G
A
C
C
C
A
C
T
C
C
C
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A
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T
T
T
C
C
C
A
T
A
T
T
C
T
T
0.09589
0.035225
0.050881
0.041096
0.037182
0.023483
0.001957
0.041096
0.058708
0.039139
0.019569
0.02544
0.029354
0.02544
0.050881
0.023483
0.043053
0.04501
0.017613
0
0.003914
0.001957
0.031311
0.035225
0.037182
0.023483
0.021526
0.015656
0.02544
0.021526
0.039139
0.039139
1
4,404
T
A
C
T
C
T
T
T
T
G
T
T
T
T
T
C
T
T
T
T
C
C
A
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C
A
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T
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A
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G
C
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G
C
A
T
T
A
G
T
T
T
C
T
C
A
G
T
T
A
A
A
A
G
0.123288
0.043053
0.039139
0.043053
0.046967
0.023483
0.001957
0.039139
0.048924
0.021526
0.027397
0.046967
0.023483
0.035225
0.035225
0.023483
0.037182
0.033268
0.019569
0.001957
0.001957
0.001957
0.027397
0.033268
0.033268
0.017613
0.019569
0.011742
0.02544
0.02544
0.056751
0.031311
1
4,405
A
A
A
A
G
A
T
T
T
T
T
T
T
A
T
A
T
A
G
G
T
T
A
T
C
G
A
C
A
T
A
C
C
G
A
C
T
A
A
C
A
G
C
A
T
T
T
C
C
A
A
A
G
A
T
G
G
A
G
C
G
A
A
T
A
T
0.09589
0.046967
0.046967
0.046967
0.054795
0.023483
0.007828
0.027397
0.046967
0.021526
0.023483
0.052838
0.037182
0.043053
0.041096
0.027397
0.02544
0.029354
0.011742
0.003914
0.007828
0.003914
0.02544
0.021526
0.039139
0.021526
0.013699
0.007828
0.02544
0.017613
0.062622
0.039139
1
4,406
T
C
T
T
C
A
C
T
G
A
G
T
A
G
T
T
T
G
C
A
T
T
G
G
A
T
A
T
G
T
A
A
C
C
A
T
T
C
A
T
T
T
T
G
A
A
G
G
C
T
A
G
G
G
T
T
T
T
A
T
C
C
T
C
A
T
0.091977
0.039139
0.039139
0.052838
0.041096
0.029354
0.001957
0.029354
0.037182
0.013699
0.033268
0.023483
0.029354
0.062622
0.039139
0.033268
0.023483
0.048924
0.029354
0.003914
0.001957
0
0.017613
0.031311
0.056751
0.015656
0.019569
0.011742
0.04501
0.013699
0.035225
0.048924
1
4,407
A
A
A
C
C
C
T
A
G
C
C
T
T
C
A
A
A
A
T
G
A
A
T
G
G
T
T
A
C
A
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A
T
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C
A
A
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C
A
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T
A
C
T
C
A
G
T
G
A
A
G
A
A
G
T
G
C
A
T
C
C
0.091977
0.041096
0.039139
0.052838
0.041096
0.029354
0.001957
0.029354
0.037182
0.015656
0.031311
0.023483
0.027397
0.060665
0.041096
0.031311
0.02544
0.048924
0.027397
0.003914
0.001957
0
0.017613
0.031311
0.056751
0.017613
0.019569
0.011742
0.043053
0.013699
0.035225
0.050881
1
4,408
A
A
A
C
T
A
C
T
C
A
G
T
G
A
A
G
A
A
G
T
G
C
A
T
C
T
T
C
T
T
A
C
T
C
T
T
C
A
T
C
A
A
C
C
G
T
A
A
G
T
T
A
A
A
A
A
G
A
A
C
C
A
C
A
T
G
0.09002
0.043053
0.04501
0.046967
0.037182
0.029354
0.001957
0.033268
0.043053
0.017613
0.037182
0.023483
0.023483
0.050881
0.041096
0.027397
0.029354
0.04501
0.02544
0.003914
0.001957
0
0.019569
0.037182
0.054795
0.015656
0.019569
0.013699
0.043053
0.015656
0.039139
0.04501
1
4,409
T
G
A
A
C
T
G
G
T
T
G
C
T
T
T
C
T
T
T
T
T
A
T
T
G
T
T
T
A
G
A
T
C
G
T
C
T
G
G
T
A
G
A
A
T
C
A
A
C
T
T
C
C
T
T
G
A
G
A
A
A
A
G
C
C
A
0.058708
0.029354
0.046967
0.02544
0.062622
0.031311
0.001957
0.037182
0.043053
0.019569
0.050881
0.02544
0.031311
0.039139
0.035225
0.04501
0.046967
0.031311
0.021526
0.001957
0.005871
0.001957
0.023483
0.033268
0.04501
0.017613
0.027397
0.021526
0.031311
0.041096
0.019569
0.046967
1
4,410
T
G
A
A
C
T
G
G
T
T
G
C
T
T
T
C
T
T
T
T
T
A
T
T
G
T
T
T
A
G
A
T
C
G
T
C
T
G
G
T
A
G
A
A
T
C
A
A
C
T
T
C
C
T
T
G
A
G
A
A
A
A
G
C
C
T
0.058708
0.029354
0.046967
0.02544
0.062622
0.031311
0.001957
0.037182
0.043053
0.019569
0.050881
0.02544
0.031311
0.039139
0.035225
0.04501
0.046967
0.031311
0.021526
0.001957
0.005871
0.001957
0.023483
0.033268
0.04501
0.017613
0.027397
0.021526
0.031311
0.041096
0.019569
0.046967
1
4,411
T
C
T
G
G
T
A
G
A
A
T
C
A
A
C
T
T
C
C
T
T
G
A
G
A
A
A
A
G
C
C
A
T
A
G
A
A
A
C
A
G
T
G
T
A
T
G
C
A
G
C
C
T
A
T
T
T
G
C
C
C
A
A
A
A
G
0.062622
0.029354
0.046967
0.031311
0.058708
0.033268
0.001957
0.037182
0.041096
0.021526
0.048924
0.02544
0.029354
0.035225
0.035225
0.046967
0.046967
0.031311
0.019569
0.001957
0.005871
0.001957
0.027397
0.029354
0.048924
0.017613
0.027397
0.019569
0.029354
0.037182
0.023483
0.046967
1
4,412
T
T
C
C
T
T
G
A
G
A
A
A
A
G
C
C
A
T
A
G
A
A
A
C
A
G
T
G
T
A
T
G
C
A
G
C
C
T
A
T
T
T
G
C
C
C
A
A
A
A
A
C
A
C
A
C
A
C
C
C
A
T
T
C
C
T
0.062622
0.029354
0.04501
0.029354
0.058708
0.033268
0.001957
0.037182
0.043053
0.021526
0.052838
0.023483
0.029354
0.035225
0.033268
0.048924
0.04501
0.029354
0.019569
0.001957
0.005871
0.001957
0.029354
0.033268
0.046967
0.017613
0.027397
0.019569
0.031311
0.035225
0.023483
0.046967
1
4,413
G
T
C
T
T
G
G
T
T
G
A
G
G
A
G
T
T
T
G
G
T
G
C
T
A
C
A
T
T
A
C
C
T
G
A
G
G
T
A
C
A
G
G
A
A
T
G
G
G
T
G
T
G
T
G
T
T
T
T
T
G
G
G
C
A
G
0.060665
0.029354
0.043053
0.033268
0.056751
0.033268
0.003914
0.029354
0.043053
0.021526
0.056751
0.027397
0.02544
0.043053
0.033268
0.046967
0.04501
0.027397
0.015656
0
0.003914
0.003914
0.027397
0.035225
0.046967
0.015656
0.037182
0.023483
0.029354
0.031311
0.023483
0.046967
1
4,414
G
T
C
T
T
G
G
T
T
G
A
G
G
A
G
T
T
T
G
G
T
G
C
T
A
C
A
T
T
A
C
C
T
G
A
G
G
T
A
C
A
G
G
A
A
T
G
G
G
T
G
T
G
T
G
T
T
T
T
T
G
G
G
C
A
C
0.060665
0.029354
0.043053
0.033268
0.056751
0.033268
0.003914
0.029354
0.043053
0.021526
0.056751
0.027397
0.02544
0.043053
0.033268
0.046967
0.04501
0.027397
0.015656
0
0.003914
0.003914
0.027397
0.035225
0.046967
0.015656
0.037182
0.023483
0.029354
0.031311
0.023483
0.046967
1
4,415
A
G
T
C
T
T
G
G
T
T
G
A
G
G
A
G
T
T
T
G
G
T
G
C
T
A
C
A
T
T
A
C
C
T
G
A
G
G
T
A
C
A
G
G
A
A
T
G
G
G
T
G
T
G
T
G
T
T
T
T
T
G
G
G
C
T
0.060665
0.029354
0.041096
0.033268
0.056751
0.033268
0.003914
0.029354
0.043053
0.021526
0.058708
0.027397
0.02544
0.043053
0.033268
0.046967
0.04501
0.027397
0.015656
0
0.003914
0.003914
0.027397
0.035225
0.046967
0.015656
0.037182
0.023483
0.029354
0.031311
0.023483
0.046967
1
4,416
T
T
A
G
A
A
A
T
C
A
G
T
C
C
C
C
A
G
A
A
T
G
T
G
G
A
T
G
T
T
A
A
T
G
T
G
C
A
C
C
C
C
A
C
A
A
A
G
C
A
T
G
A
A
G
T
T
C
A
C
T
T
C
C
T
A
0.054795
0.021526
0.04501
0.033268
0.043053
0.019569
0.007828
0.033268
0.050881
0.037182
0.037182
0.019569
0.029354
0.035225
0.029354
0.043053
0.050881
0.043053
0.033268
0.005871
0.009785
0.007828
0.015656
0.046967
0.041096
0.015656
0.037182
0.031311
0.035225
0.021526
0.029354
0.035225
1
4,417
A
G
G
A
A
T
T
G
G
A
G
C
C
C
A
G
G
A
G
C
T
T
G
C
T
C
T
C
G
A
T
G
T
G
C
T
G
C
T
G
C
A
C
C
C
G
C
T
C
C
A
G
G
A
T
G
C
T
C
T
C
C
T
C
G
G
0.050881
0.027397
0.039139
0.033268
0.041096
0.023483
0.005871
0.033268
0.04501
0.035225
0.046967
0.027397
0.02544
0.031311
0.029354
0.04501
0.048924
0.043053
0.033268
0.005871
0.009785
0.005871
0.021526
0.046967
0.041096
0.015656
0.033268
0.035225
0.037182
0.015656
0.029354
0.037182
1
4,418
A
G
A
G
A
A
G
T
A
G
C
T
G
G
A
T
G
A
G
A
A
G
C
G
C
C
C
T
G
A
C
C
T
G
G
G
T
G
A
A
G
T
A
C
A
T
C
C
T
G
G
A
G
G
A
A
T
T
G
G
A
G
C
C
C
C
0.050881
0.029354
0.046967
0.029354
0.035225
0.023483
0.007828
0.029354
0.046967
0.035225
0.052838
0.023483
0.023483
0.033268
0.027397
0.037182
0.04501
0.04501
0.033268
0.005871
0.007828
0.005871
0.027397
0.04501
0.046967
0.013699
0.033268
0.035225
0.04501
0.015656
0.031311
0.031311
1
4,419
C
A
G
A
G
A
A
G
T
A
G
C
T
G
G
A
T
G
A
G
A
A
G
C
G
C
C
C
T
G
A
C
C
T
G
G
G
T
G
A
A
G
T
A
C
A
T
C
C
T
G
G
A
G
G
A
A
T
T
G
G
A
G
C
C
G
0.050881
0.029354
0.046967
0.029354
0.033268
0.023483
0.007828
0.029354
0.046967
0.035225
0.052838
0.023483
0.023483
0.033268
0.027397
0.037182
0.04501
0.04501
0.033268
0.005871
0.007828
0.005871
0.027397
0.046967
0.046967
0.013699
0.033268
0.035225
0.04501
0.015656
0.031311
0.031311
1
4,420
C
A
G
A
G
A
A
G
T
A
G
C
T
G
G
A
T
G
A
G
A
A
G
C
G
C
C
C
T
G
A
C
C
T
G
G
G
T
G
A
A
G
T
A
C
A
T
C
C
T
G
G
A
G
G
A
A
T
T
G
G
A
G
C
C
A
0.050881
0.029354
0.046967
0.029354
0.033268
0.023483
0.007828
0.029354
0.046967
0.035225
0.052838
0.023483
0.023483
0.033268
0.027397
0.037182
0.04501
0.04501
0.033268
0.005871
0.007828
0.005871
0.027397
0.046967
0.046967
0.013699
0.033268
0.035225
0.04501
0.015656
0.031311
0.031311
1
4,421
C
T
T
G
G
C
A
C
A
G
C
A
T
C
A
A
A
C
C
A
A
G
T
T
A
T
A
C
C
T
T
C
T
C
A
A
C
A
C
C
A
C
C
A
A
G
C
T
T
A
G
G
T
A
A
A
T
C
A
G
C
T
G
A
G
C
0.060665
0.04501
0.039139
0.037182
0.054795
0.039139
0.003914
0.037182
0.031311
0.037182
0.037182
0.023483
0.015656
0.029354
0.052838
0.04501
0.039139
0.046967
0.017613
0.003914
0.007828
0
0.027397
0.037182
0.035225
0.017613
0.029354
0.019569
0.029354
0.027397
0.035225
0.037182
1
4,422
G
C
T
C
T
G
C
T
T
G
T
T
C
A
C
A
C
A
C
T
C
A
G
C
T
G
A
T
T
T
A
C
C
T
A
A
G
C
T
T
G
G
T
G
G
T
G
T
T
G
A
G
A
A
G
G
T
A
T
A
A
C
T
T
G
A
0.060665
0.048924
0.039139
0.031311
0.058708
0.041096
0.003914
0.037182
0.031311
0.037182
0.037182
0.015656
0.015656
0.031311
0.056751
0.04501
0.041096
0.046967
0.021526
0.003914
0.007828
0
0.027397
0.035225
0.033268
0.017613
0.033268
0.019569
0.027397
0.027397
0.031311
0.035225
1
4,423
T
G
T
T
C
T
T
G
C
T
T
C
T
T
C
C
T
A
G
G
A
G
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C
C
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C
T
C
T
T
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C
T
T
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C
C
A
T
G
C
T
T
G
C
C
T
T
A
G
A
T
A
G
T
C
A
0.046967
0.021526
0.064579
0.039139
0.035225
0.023483
0.003914
0.019569
0.052838
0.043053
0.041096
0.02544
0.023483
0.041096
0.048924
0.02544
0.043053
0.050881
0.027397
0.009785
0.001957
0.003914
0.011742
0.037182
0.060665
0.019569
0.031311
0.031311
0.04501
0.013699
0.015656
0.041096
1
4,424
T
G
T
T
C
T
T
G
C
T
T
C
T
T
C
C
T
A
G
G
A
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C
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C
A
T
G
C
T
T
G
C
C
T
T
A
G
A
T
A
G
T
C
C
0.046967
0.021526
0.064579
0.039139
0.035225
0.023483
0.003914
0.019569
0.052838
0.043053
0.041096
0.02544
0.023483
0.041096
0.048924
0.02544
0.043053
0.050881
0.027397
0.009785
0.001957
0.003914
0.011742
0.037182
0.060665
0.019569
0.031311
0.031311
0.04501
0.013699
0.015656
0.041096
1
4,425
T
G
T
T
G
A
G
T
T
T
C
T
G
A
A
G
A
A
G
A
A
G
G
C
T
G
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T
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T
A
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C
T
C
T
T
T
G
G
A
A
A
T
T
G
A
T
G
A
G
G
A
0.050881
0.023483
0.052838
0.041096
0.02544
0.029354
0.005871
0.023483
0.050881
0.050881
0.031311
0.021526
0.023483
0.039139
0.041096
0.02544
0.046967
0.056751
0.027397
0.013699
0
0.007828
0.019569
0.035225
0.052838
0.017613
0.031311
0.035225
0.037182
0.017613
0.023483
0.041096
1
4,426
T
G
T
T
G
A
G
T
T
T
C
T
G
A
A
G
A
A
G
A
A
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C
T
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C
T
C
T
T
T
G
G
A
A
A
T
T
G
A
T
G
A
G
G
C
0.050881
0.023483
0.052838
0.041096
0.02544
0.029354
0.005871
0.023483
0.050881
0.050881
0.031311
0.021526
0.023483
0.039139
0.041096
0.02544
0.046967
0.056751
0.027397
0.013699
0
0.007828
0.019569
0.035225
0.052838
0.017613
0.031311
0.035225
0.037182
0.017613
0.023483
0.041096
1
4,427
T
T
G
G
A
T
T
A
C
C
C
C
T
T
C
T
G
A
T
T
G
A
C
A
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C
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G
A
C
T
G
C
C
T
A
T
C
T
T
C
A
T
T
C
T
T
T
0.068493
0.027397
0.04501
0.037182
0.031311
0.021526
0.009785
0.033268
0.029354
0.029354
0.046967
0.027397
0.037182
0.035225
0.033268
0.033268
0.052838
0.037182
0.048924
0.003914
0.007828
0.001957
0.021526
0.017613
0.043053
0.021526
0.043053
0.027397
0.039139
0.013699
0.031311
0.043053
1
4,428
T
G
A
C
A
A
C
T
A
T
G
T
G
C
C
C
C
C
T
T
T
G
G
A
G
G
G
A
C
T
G
C
C
T
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T
C
G
A
C
T
A
G
C
C
A
C
T
G
A
G
G
T
C
A
T
0.066536
0.023483
0.046967
0.037182
0.031311
0.019569
0.007828
0.037182
0.027397
0.033268
0.04501
0.027397
0.037182
0.035225
0.031311
0.033268
0.052838
0.037182
0.048924
0.001957
0.007828
0.001957
0.02544
0.017613
0.039139
0.023483
0.041096
0.02544
0.039139
0.015656
0.037182
0.04501
1
4,429
T
A
T
C
T
G
C
T
T
G
A
T
C
A
C
T
G
A
C
C
T
C
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G
G
C
T
A
G
T
C
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A
A
G
A
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T
G
A
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A
T
A
G
G
C
A
G
T
C
C
C
T
C
C
A
A
A
G
G
G
G
0.066536
0.023483
0.046967
0.039139
0.027397
0.019569
0.009785
0.037182
0.031311
0.031311
0.043053
0.027397
0.039139
0.035225
0.029354
0.033268
0.048924
0.037182
0.048924
0.003914
0.007828
0.001957
0.027397
0.019569
0.041096
0.021526
0.039139
0.02544
0.039139
0.015656
0.039139
0.043053
1
4,430
T
A
T
C
T
G
C
T
T
G
A
T
C
A
C
T
G
A
C
C
T
C
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G
G
C
T
A
G
T
C
G
A
A
G
A
A
T
G
A
A
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A
T
A
G
G
C
A
G
T
C
C
C
T
C
C
A
A
A
G
G
G
A
0.066536
0.023483
0.046967
0.039139
0.027397
0.019569
0.009785
0.037182
0.031311
0.031311
0.043053
0.027397
0.039139
0.035225
0.029354
0.033268
0.048924
0.037182
0.048924
0.003914
0.007828
0.001957
0.027397
0.019569
0.041096
0.021526
0.039139
0.02544
0.039139
0.015656
0.039139
0.043053
1
4,431
C
C
G
A
A
A
T
G
C
T
T
A
G
T
A
T
C
T
G
C
T
T
G
A
T
C
A
C
T
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A
C
C
T
C
A
G
T
G
G
C
T
A
G
T
C
G
A
A
G
A
A
T
G
A
A
G
A
T
A
G
G
C
A
G
A
0.058708
0.023483
0.04501
0.043053
0.029354
0.019569
0.009785
0.035225
0.031311
0.031311
0.043053
0.027397
0.039139
0.037182
0.029354
0.033268
0.048924
0.037182
0.048924
0.003914
0.007828
0.001957
0.027397
0.019569
0.041096
0.021526
0.039139
0.02544
0.039139
0.015656
0.043053
0.043053
1
4,432
T
A
T
G
T
A
C
T
G
C
T
T
C
C
G
G
A
T
G
G
A
A
T
A
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A
A
C
A
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C
G
C
A
T
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C
T
T
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C
T
G
A
G
G
C
T
T
T
C
A
A
A
A
C
A
T
T
C
C
T
T
0.072407
0.02544
0.035225
0.050881
0.035225
0.027397
0.009785
0.031311
0.039139
0.027397
0.041096
0.031311
0.033268
0.041096
0.02544
0.023483
0.046967
0.031311
0.02544
0.007828
0.011742
0.005871
0.027397
0.031311
0.050881
0.021526
0.021526
0.015656
0.037182
0.033268
0.033268
0.048924
1
4,433
T
C
A
G
T
A
A
A
G
A
A
T
G
C
G
C
T
A
T
G
T
T
C
T
A
T
T
C
C
A
T
C
C
G
G
A
A
G
C
A
G
T
A
C
A
T
A
T
C
T
G
A
G
G
A
G
T
C
G
A
C
C
C
T
C
T
0.076321
0.02544
0.031311
0.056751
0.039139
0.02544
0.009785
0.031311
0.039139
0.027397
0.039139
0.029354
0.027397
0.041096
0.029354
0.023483
0.046967
0.029354
0.021526
0.007828
0.011742
0.005871
0.027397
0.031311
0.054795
0.023483
0.021526
0.015656
0.035225
0.033268
0.031311
0.050881
1
4,434
C
C
T
G
G
G
G
T
G
C
C
A
G
T
G
T
G
C
A
T
C
A
C
C
A
C
T
G
T
A
C
C
T
G
C
T
G
G
C
C
T
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A
G
A
G
G
G
T
C
G
A
C
T
C
C
T
C
A
G
A
T
A
T
G
C
0.080235
0.031311
0.031311
0.054795
0.04501
0.027397
0.009785
0.033268
0.041096
0.021526
0.037182
0.023483
0.029354
0.041096
0.035225
0.027397
0.043053
0.029354
0.017613
0.007828
0.011742
0.005871
0.02544
0.033268
0.050881
0.023483
0.019569
0.013699
0.033268
0.033268
0.031311
0.050881
1
4,435
T
C
C
T
G
G
G
G
T
G
C
C
A
G
T
G
T
G
C
A
T
C
A
C
C
A
C
T
G
T
A
C
C
T
G
C
T
G
G
C
C
T
G
A
G
A
G
G
G
T
C
G
A
C
T
C
C
T
C
A
G
A
T
A
T
G
0.080235
0.031311
0.031311
0.054795
0.046967
0.027397
0.009785
0.033268
0.041096
0.021526
0.037182
0.023483
0.029354
0.041096
0.035225
0.027397
0.043053
0.029354
0.017613
0.007828
0.011742
0.005871
0.02544
0.033268
0.050881
0.023483
0.017613
0.013699
0.033268
0.033268
0.031311
0.050881
1
4,436
A
A
A
T
A
T
C
C
T
G
C
A
G
C
T
T
G
C
T
A
A
C
C
T
G
C
C
T
G
A
T
C
T
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T
A
C
A
A
A
G
T
C
T
T
T
G
A
G
A
G
G
T
G
T
T
A
A
A
T
A
T
G
G
T
C
0.046967
0.029354
0.050881
0.041096
0.076321
0.015656
0
0.039139
0.041096
0.019569
0.029354
0.076321
0.033268
0.037182
0.035225
0.054795
0.041096
0.039139
0.011742
0.001957
0.001957
0.003914
0.019569
0.017613
0.033268
0.019569
0.029354
0.017613
0.037182
0.02544
0.050881
0.023483
1
4,437
C
C
C
A
C
A
G
T
G
C
A
T
A
A
A
T
A
A
C
C
A
T
A
T
T
T
A
A
C
A
C
C
T
C
T
C
A
A
A
G
A
C
T
T
T
G
T
A
T
A
G
A
T
C
A
G
G
C
A
G
G
T
T
A
G
C
0.052838
0.029354
0.050881
0.041096
0.074364
0.013699
0
0.039139
0.043053
0.017613
0.027397
0.074364
0.033268
0.039139
0.035225
0.052838
0.043053
0.039139
0.009785
0.001957
0.001957
0.003914
0.015656
0.019569
0.035225
0.019569
0.031311
0.017613
0.037182
0.02544
0.048924
0.02544
1
4,438
G
C
T
G
T
A
G
T
T
G
G
A
G
G
A
G
T
C
T
G
T
T
C
T
C
C
A
T
C
C
A
G
C
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G
G
G
T
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G
A
T
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C
T
G
C
T
C
A
G
G
T
G
C
C
C
C
A
C
G
T
T
G
T
T
0.011742
0.017613
0.021526
0.015656
0.02544
0.033268
0.013699
0.019569
0.041096
0.043053
0.066536
0.009785
0.017613
0.019569
0.019569
0.037182
0.080235
0.072407
0.068493
0.019569
0.013699
0.003914
0.005871
0.062622
0.031311
0.02544
0.033268
0.072407
0.054795
0.011742
0.003914
0.027397
1
4,439
G
A
G
C
C
C
A
C
T
C
G
G
C
T
G
T
C
C
T
G
G
C
T
C
T
G
C
A
G
G
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G
T
G
T
G
A
C
C
A
C
T
C
C
C
A
G
A
C
A
G
A
C
T
C
C
C
T
G
G
A
G
G
A
C
C
0.011742
0.013699
0.039139
0.005871
0.023483
0.027397
0.009785
0.023483
0.037182
0.062622
0.068493
0.001957
0.021526
0.013699
0.02544
0.027397
0.078278
0.043053
0.054795
0.02544
0.021526
0.02544
0.009785
0.062622
0.029354
0.035225
0.039139
0.060665
0.050881
0.007828
0.003914
0.039139
1
4,440
T
G
G
C
G
C
C
T
C
T
G
T
A
G
G
C
C
G
A
C
T
G
C
T
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A
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C
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C
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C
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C
T
G
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C
C
G
C
G
A
C
G
A
C
G
T
G
C
T
G
C
T
G
G
C
0.007828
0.015656
0.031311
0.007828
0.019569
0.033268
0.021526
0.019569
0.037182
0.039139
0.058708
0.005871
0.011742
0.021526
0.015656
0.019569
0.064579
0.050881
0.058708
0.052838
0.021526
0.048924
0.003914
0.054795
0.02544
0.046967
0.037182
0.062622
0.066536
0.011742
0.013699
0.013699
1
4,441
T
G
G
C
C
T
C
T
G
G
G
T
C
A
A
A
T
T
T
C
T
C
C
C
A
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A
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C
T
C
A
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A
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A
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A
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T
C
G
A
A
G
T
C
G
T
C
C
T
C
A
C
T
C
A
G
G
G
G
C
C
0.013699
0.017613
0.02544
0.015656
0.021526
0.02544
0.013699
0.029354
0.043053
0.023483
0.043053
0.013699
0.041096
0.058708
0.027397
0.029354
0.046967
0.066536
0.060665
0.02544
0.021526
0.013699
0.005871
0.060665
0.027397
0.031311
0.027397
0.056751
0.052838
0.011742
0.003914
0.04501
1
4,442
A
G
C
C
C
C
T
G
A
G
T
G
A
G
G
A
C
G
A
C
T
T
C
G
A
T
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T
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C
T
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C
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A
G
A
A
A
T
T
T
G
A
C
C
C
A
G
A
G
G
C
C
C
0.013699
0.017613
0.02544
0.015656
0.021526
0.02544
0.013699
0.029354
0.043053
0.023483
0.043053
0.013699
0.041096
0.056751
0.027397
0.029354
0.046967
0.066536
0.060665
0.02544
0.021526
0.013699
0.005871
0.060665
0.027397
0.033268
0.027397
0.056751
0.052838
0.011742
0.003914
0.04501
1
4,443
A
T
T
T
C
T
C
C
C
A
G
A
T
C
T
C
A
T
A
G
A
A
C
A
T
A
T
C
G
A
A
G
T
C
G
T
C
C
T
C
A
C
T
C
A
G
G
G
G
C
T
C
G
G
T
G
C
T
C
T
C
C
T
C
C
C
0.013699
0.015656
0.023483
0.015656
0.021526
0.027397
0.017613
0.027397
0.043053
0.023483
0.041096
0.013699
0.04501
0.054795
0.027397
0.033268
0.048924
0.068493
0.060665
0.02544
0.021526
0.013699
0.005871
0.056751
0.02544
0.033268
0.027397
0.056751
0.050881
0.011742
0.003914
0.04501
1
4,444
G
G
C
C
A
C
G
C
T
G
A
A
G
T
T
C
T
C
C
A
G
G
A
T
G
A
T
G
G
C
A
A
T
G
T
A
C
A
T
G
T
T
G
A
C
C
A
C
G
A
T
G
A
G
G
A
A
G
G
A
G
A
T
G
A
C
0.007828
0.021526
0.023483
0.013699
0.029354
0.02544
0.017613
0.029354
0.035225
0.029354
0.039139
0.013699
0.039139
0.060665
0.029354
0.035225
0.048924
0.066536
0.048924
0.02544
0.029354
0.013699
0.005871
0.054795
0.02544
0.033268
0.033268
0.060665
0.04501
0.011742
0.003914
0.043053
1
4,445
A
C
G
C
T
G
A
A
G
T
T
C
T
C
C
A
G
G
A
T
G
A
T
G
G
C
A
A
T
G
T
A
C
A
T
G
T
T
G
A
C
C
A
C
G
A
T
G
A
G
G
A
A
G
G
A
G
A
T
G
A
T
G
A
T
G
0.007828
0.021526
0.023483
0.013699
0.029354
0.02544
0.017613
0.029354
0.035225
0.029354
0.039139
0.013699
0.039139
0.060665
0.029354
0.035225
0.048924
0.066536
0.048924
0.02544
0.029354
0.013699
0.005871
0.054795
0.02544
0.033268
0.033268
0.060665
0.043053
0.011742
0.003914
0.04501
1
4,446
G
C
T
G
A
A
G
T
T
C
T
C
C
A
G
G
A
T
G
A
T
G
G
C
A
A
T
G
T
A
C
A
T
G
T
T
G
A
C
C
A
C
G
A
T
G
A
G
G
A
A
G
G
A
G
A
T
G
A
T
G
A
T
G
T
A
0.007828
0.021526
0.023483
0.013699
0.029354
0.02544
0.017613
0.029354
0.035225
0.029354
0.039139
0.015656
0.039139
0.058708
0.029354
0.035225
0.048924
0.064579
0.048924
0.02544
0.029354
0.013699
0.005871
0.054795
0.02544
0.033268
0.033268
0.060665
0.043053
0.011742
0.005871
0.04501
1