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int64
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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T
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T
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A
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G
A
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G
G
A
A
A
C
A
A
G
G
T
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T
A
T
A
T
T
T
A
C
C
T
G
C
T
G
G
A
C
T
G
C
T
C
C
C
C
G
T
C
T
C
C
T
C
T
G
C
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G
G
G
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C
A
G
G
C
C
A
C
G
T
G
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0
34,785
C
C
C
A
A
C
T
T
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G
G
G
G
A
T
C
C
C
A
C
A
G
T
C
T
A
C
C
T
T
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A
C
A
T
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A
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T
T
T
C
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A
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C
C
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0
34,786
C
A
A
A
G
G
C
C
T
T
T
G
C
C
T
C
A
C
T
G
A
C
T
A
C
A
G
C
T
C
C
C
C
C
A
A
C
T
T
G
G
G
G
G
A
T
C
C
C
A
C
A
G
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C
T
A
C
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T
T
G
A
C
A
T
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34,787
C
T
A
G
C
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A
T
A
C
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T
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G
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T
A
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T
G
G
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T
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A
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A
G
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C
C
C
T
C
T
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T
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A
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T
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34,788
C
T
T
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A
T
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C
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A
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G
T
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A
T
A
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C
G
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A
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G
G
C
A
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T
C
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0
34,789
A
G
T
G
A
G
A
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A
T
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T
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A
A
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34,790
C
A
A
T
C
A
C
T
T
C
C
T
G
G
C
T
A
T
G
G
G
A
C
C
T
C
A
C
T
A
C
A
T
C
T
C
T
C
C
C
C
A
C
T
A
C
A
A
C
T
T
G
G
C
C
A
A
G
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A
C
T
A
G
T
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0
34,791
C
T
A
T
G
G
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A
A
A
C
A
G
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A
C
T
C
A
C
A
C
T
T
C
C
A
T
G
A
C
T
T
A
C
A
C
A
G
A
G
A
A
G
A
G
T
G
A
A
G
T
G
T
C
T
T
C
T
T
C
A
A
T
C
G
0.021526
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0
34,792
A
C
T
C
A
G
T
G
A
G
G
A
C
A
C
T
C
A
G
A
A
C
C
A
C
A
G
A
A
A
A
C
C
A
T
C
C
A
A
A
G
A
C
A
G
A
G
T
C
C
G
C
C
A
C
C
C
C
A
G
C
T
G
C
T
T
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34,793
T
G
G
C
A
T
C
T
T
G
T
C
C
T
C
A
T
C
T
C
C
T
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C
T
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T
C
C
T
A
C
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C
C
C
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A
A
G
T
C
A
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34,794
C
T
C
T
G
T
T
G
T
G
A
G
G
A
T
G
G
T
T
G
T
T
G
A
T
G
G
T
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C
C
C
T
G
A
T
A
G
A
A
G
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G
C
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0
34,795
T
G
C
C
A
C
A
C
T
G
G
T
T
G
A
T
G
C
T
G
G
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C
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C
A
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C
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A
C
T
T
G
T
C
T
C
C
A
C
C
C
A
C
T
G
T
G
C
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0
34,796
T
T
G
A
T
G
G
A
G
T
C
C
C
C
A
G
A
G
A
G
G
A
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T
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C
A
C
T
T
G
T
T
T
C
T
G
C
A
T
T
G
C
T
T
T
0.027397
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0
34,797
G
C
C
A
T
A
C
T
G
A
G
G
T
T
C
C
A
T
G
T
G
G
G
G
A
T
G
A
C
G
A
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T
T
C
T
C
C
C
C
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G
G
C
T
C
G
T
G
A
G
T
T
C
C
T
G
T
G
A
G
G
A
G
A
C
0.054795
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0
34,798
A
G
A
C
T
G
C
A
G
T
G
G
C
T
T
C
A
G
T
G
A
T
G
T
A
T
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C
T
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T
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T
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C
C
C
T
C
A
A
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G
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T
G
A
A
C
C
C
C
T
T
T
A
T
C
T
A
T
A
G
T
G
0.056751
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0.04501
0
34,799
T
G
G
G
G
C
A
G
G
T
T
T
G
G
G
G
G
T
G
T
A
C
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C
A
C
C
T
A
G
G
A
A
G
A
C
T
G
C
A
G
T
G
G
C
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0
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0
0
0
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0
34,800
C
A
G
A
A
C
T
A
A
T
G
T
A
C
A
C
C
C
C
A
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A
A
A
C
A
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A
G
A
G
G
T
G
A
C
A
G
C
C
A
C
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0.052838
0
34,801
C
C
T
G
G
T
T
C
A
G
A
G
T
C
T
G
A
T
G
G
T
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T
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C
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C
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C
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C
A
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C
G
T
T
G
A
A
A
T
C
C
C
T
T
T
G
T
T
C
T
T
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0.054795
0
34,802
T
C
T
T
C
T
C
T
C
C
A
T
G
T
T
C
A
T
G
A
G
C
A
C
T
A
T
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G
A
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C
C
C
T
G
G
T
T
C
A
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A
G
T
C
T
G
A
T
G
G
T
A
T
T
G
C
A
G
C
T
G
T
T
0.046967
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0
34,803
T
T
T
A
A
C
C
A
C
A
A
C
C
A
C
A
G
T
C
C
C
A
A
A
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A
T
C
C
T
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G
T
G
A
A
C
A
T
C
C
A
A
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C
T
C
A
G
A
A
T
C
A
G
A
G
T
A
T
C
A
C
T
T
C
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0
34,804
C
A
T
T
G
T
G
G
C
C
A
G
G
T
A
C
A
T
G
G
A
C
A
G
G
A
A
C
A
G
C
A
T
G
A
A
G
A
G
G
A
T
G
G
G
C
T
G
C
A
G
C
T
C
C
G
G
A
T
C
C
C
C
T
G
C
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0
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0.064579
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0
34,805
C
A
G
T
C
C
C
C
A
A
G
A
T
G
C
T
A
G
T
G
A
G
C
A
T
C
C
A
G
G
C
A
C
G
G
A
G
C
A
A
A
G
A
C
A
T
C
T
C
C
T
A
C
A
T
G
G
G
G
T
G
C
C
T
C
T
0.035225
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0
0
0.013699
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0.021526
0.007828
0.052838
0
34,806
A
C
A
G
C
T
C
A
C
C
T
G
C
T
T
C
A
A
G
G
A
T
G
T
G
G
A
C
A
T
T
T
C
T
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A
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C
T
T
C
T
G
T
G
A
C
C
C
T
T
C
T
C
A
A
C
T
C
C
T
C
C
T
0.060665
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0
34,807
G
G
A
T
C
C
T
T
T
T
C
T
C
T
T
A
C
T
A
T
A
A
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G
T
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C
C
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C
A
T
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C
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G
A
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A
G
T
T
C
C
A
A
C
A
T
C
A
G
A
T
G
G
G
A
A
G
T
0.04501
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0.02544
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0.037182
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0.027397
0.046967
0
34,808
T
C
C
T
G
G
G
G
G
A
A
A
A
A
C
A
T
C
C
A
A
T
G
G
C
A
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A
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C
A
C
G
G
T
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A
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A
C
T
T
A
C
T
A
G
G
A
A
G
T
A
T
T
C
C
T
G
G
T
C
T
T
T
0.084149
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0
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0
34,809
A
G
T
G
C
T
T
G
T
G
C
T
A
A
A
G
G
C
T
T
T
T
T
C
A
C
A
C
T
G
A
A
T
A
C
A
T
T
T
A
T
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A
G
G
C
T
T
C
T
C
T
C
C
A
G
T
G
T
G
A
G
T
T
C
A
0.046967
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0
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0.046967
0
34,810
C
T
G
C
T
C
G
A
A
C
A
G
T
T
G
C
T
G
G
G
G
A
G
A
C
T
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C
T
T
T
T
T
G
C
T
C
A
G
T
G
T
C
C
T
C
C
A
G
A
A
A
A
G
A
A
A
G
A
T
C
C
A
G
A
C
0.04501
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0.031311
0.033268
0.023483
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0.017613
0.021526
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0.013699
0.027397
0.050881
0
34,811
T
G
A
C
A
C
G
T
T
C
T
C
A
C
C
T
C
G
C
G
G
G
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T
G
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C
A
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C
T
G
C
T
G
A
T
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C
C
C
A
T
G
G
T
A
A
G
C
T
C
T
G
T
T
G
C
T
C
T
T
T
0.035225
0.027397
0.023483
0.048924
0.039139
0.033268
0.007828
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0.021526
0.035225
0.050881
0
34,812
C
T
C
C
A
G
T
G
T
G
A
G
T
T
C
G
T
G
T
G
T
G
A
A
C
G
T
T
A
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G
T
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A
A
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C
C
T
G
A
A
G
G
C
T
T
T
C
C
C
A
C
A
T
T
C
T
C
0.066536
0.033268
0.058708
0.048924
0.050881
0.015656
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0.021526
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0.039139
0.021526
0.066536
0.019569
0.048924
0.021526
0.027397
0.009785
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0.007828
0.005871
0.017613
0.02544
0.072407
0.003914
0.031311
0.015656
0.035225
0.023483
0.048924
0.046967
0
34,813
G
A
G
C
A
A
A
T
G
C
T
T
T
A
C
C
G
C
A
T
T
C
C
T
T
A
C
A
T
T
C
A
C
A
G
G
C
C
T
T
T
T
C
T
C
C
A
G
T
G
T
G
A
G
T
T
C
T
T
A
A
A
T
G
G
T
0.068493
0.029354
0.064579
0.043053
0.060665
0.011742
0.011742
0.031311
0.029354
0.029354
0.037182
0.027397
0.009785
0.068493
0.019569
0.050881
0.021526
0.027397
0.015656
0.003914
0.009785
0.005871
0.011742
0.031311
0.068493
0.003914
0.033268
0.021526
0.035225
0.029354
0.048924
0.039139
0
34,814
T
C
T
T
G
A
T
G
C
A
C
A
G
G
A
G
C
T
G
A
A
G
G
A
C
A
G
G
A
T
G
A
C
G
G
A
A
C
T
G
T
T
G
C
C
C
C
T
G
A
G
C
T
C
G
G
T
C
C
T
G
G
A
G
C
T
0.011742
0.017613
0.027397
0.017613
0.033268
0.04501
0.011742
0.021526
0.033268
0.023483
0.066536
0.011742
0.023483
0.04501
0.039139
0.027397
0.062622
0.064579
0.046967
0.021526
0.001957
0.015656
0.009785
0.04501
0.019569
0.048924
0.031311
0.050881
0.056751
0.017613
0.003914
0.046967
0
34,815
T
G
G
C
C
G
A
G
A
G
G
G
A
C
C
C
A
T
C
A
G
C
T
G
C
C
C
G
G
A
G
C
C
G
C
G
C
A
T
C
C
A
G
G
C
T
C
C
G
C
A
T
G
A
G
G
G
T
C
T
C
C
A
T
G
T
0.015656
0.019569
0.029354
0.015656
0.037182
0.04501
0.011742
0.019569
0.039139
0.029354
0.060665
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0.021526
0.054795
0.072407
0.046967
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0.009785
0.017613
0.011742
0.052838
0.021526
0.054795
0.019569
0.039139
0.064579
0.017613
0.005871
0.033268
0
34,816
C
C
A
C
C
C
T
C
T
T
A
C
C
C
G
G
C
A
G
C
C
A
T
C
C
T
G
G
G
G
G
A
C
G
C
T
G
A
C
A
G
T
G
G
C
T
G
C
T
G
T
C
G
T
C
T
G
G
T
T
G
A
A
A
G
T
0.021526
0.019569
0.035225
0.011742
0.023483
0.027397
0.02544
0.031311
0.046967
0.052838
0.039139
0
0.009785
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0.037182
0.078278
0.058708
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0.031311
0.023483
0.013699
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0.04501
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0.035225
0.058708
0.043053
0.009785
0.003914
0.029354
0
34,817
A
G
G
G
T
C
T
C
C
C
T
T
G
G
G
A
C
C
A
G
G
G
G
G
T
C
C
C
T
G
C
A
C
G
C
C
T
G
G
C
A
A
C
C
C
C
T
G
A
T
C
T
C
C
T
T
T
C
T
C
A
C
C
A
G
T
0.027397
0.019569
0.029354
0.02544
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0.039139
0.011742
0.011742
0.052838
0.017613
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0.029354
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0.11546
0.011742
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0.011742
0.060665
0.035225
0.035225
0.021526
0.02544
0.07045
0.001957
0.009785
0.029354
0
34,818
A
G
G
G
A
G
C
A
G
A
C
G
G
G
G
C
T
C
A
G
G
G
G
C
G
C
C
G
G
G
G
A
C
C
C
C
C
A
G
G
C
C
T
C
T
T
T
G
G
G
C
A
G
A
A
A
G
G
A
G
A
T
G
A
C
T
0.023483
0.035225
0.039139
0.015656
0.023483
0.046967
0.007828
0.035225
0.043053
0.013699
0.064579
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0.039139
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0.052838
0.048924
0.097847
0.017613
0.005871
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0.011742
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0.02544
0.039139
0.027397
0.037182
0.046967
0.003914
0.02544
0.041096
0
34,819
G
C
C
C
T
A
G
G
A
A
T
G
G
G
A
T
G
G
G
C
A
A
G
T
C
A
C
T
T
A
C
C
C
G
G
G
A
C
C
C
C
T
T
C
T
T
G
C
C
T
G
C
A
G
G
G
C
C
A
A
C
G
G
G
G
G
0.015656
0.019569
0.031311
0.013699
0.02544
0.035225
0.005871
0.017613
0.023483
0.027397
0.091977
0.009785
0.019569
0.023483
0.019569
0.027397
0.080235
0.064579
0.105675
0.007828
0.003914
0.009785
0.009785
0.039139
0.031311
0.021526
0.037182
0.07045
0.058708
0.013699
0.013699
0.02544
0
34,820
C
T
C
A
C
T
C
A
C
C
A
C
T
G
T
G
G
C
T
G
C
C
G
G
T
G
C
C
A
G
G
T
T
G
T
C
A
C
A
G
T
C
G
G
G
G
A
G
G
T
A
C
C
G
C
T
C
A
C
A
A
G
C
C
T
A
0.003914
0.015656
0.027397
0.015656
0.029354
0.046967
0.005871
0.031311
0.027397
0.039139
0.068493
0.015656
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0.019569
0.043053
0.066536
0.052838
0.078278
0.009785
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0.017613
0.052838
0.019569
0.041096
0.027397
0.037182
0.048924
0.013699
0.019569
0.058708
0
34,821
C
A
T
C
T
G
T
G
A
G
G
T
T
G
A
C
C
T
G
C
T
G
G
G
G
G
A
G
G
G
G
G
C
G
G
A
A
G
G
G
G
T
C
A
C
C
T
A
G
G
A
G
A
C
C
C
A
G
C
G
C
T
G
G
C
T
0.011742
0.013699
0.029354
0.003914
0.017613
0.046967
0.007828
0.027397
0.02544
0.04501
0.062622
0.007828
0.017613
0.02544
0.017613
0.048924
0.074364
0.064579
0.099804
0.02544
0
0.013699
0.011742
0.04501
0.023483
0.029354
0.041096
0.060665
0.04501
0.007828
0.003914
0.04501
0
34,822
C
T
T
C
C
A
G
G
C
A
T
G
A
A
G
A
G
G
A
G
G
C
G
G
C
A
G
G
G
C
C
A
C
A
T
C
G
T
G
G
T
G
A
T
C
A
G
C
A
G
T
G
T
C
A
T
G
G
G
C
C
T
G
C
A
G
0.02544
0.013699
0.037182
0.02544
0.021526
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0.013699
0.029354
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0.021526
0.043053
0.031311
0.031311
0.037182
0.046967
0.04501
0.013699
0.023483
0.041096
0
34,823
G
T
T
T
G
A
G
G
G
G
A
A
G
C
T
T
C
T
G
G
C
G
C
A
G
G
T
T
T
C
T
A
T
G
G
C
T
G
A
G
T
T
C
C
C
A
G
G
C
A
C
T
G
A
C
C
C
T
G
A
G
A
C
C
C
C
0.039139
0.02544
0.015656
0.009785
0.021526
0.041096
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0.027397
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0.011742
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0.02544
0.023483
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0.076321
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0.062622
0.015656
0.013699
0.017613
0.011742
0.054795
0.021526
0.037182
0.035225
0.052838
0.04501
0.009785
0.005871
0.041096
0
34,824
A
G
G
G
T
C
T
C
A
G
G
G
T
C
A
G
T
G
C
C
T
G
G
G
A
A
C
T
C
A
G
C
C
A
T
A
G
A
A
A
C
C
T
G
C
G
C
C
A
G
A
A
G
C
T
T
C
C
C
C
T
C
A
A
A
T
0.039139
0.02544
0.015656
0.009785
0.023483
0.041096
0.015656
0.027397
0.029354
0.039139
0.062622
0.011742
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0.023483
0.035225
0.074364
0.060665
0.062622
0.015656
0.013699
0.017613
0.011742
0.054795
0.021526
0.037182
0.035225
0.052838
0.04501
0.009785
0.005871
0.041096
0
34,825
A
T
A
G
C
G
C
C
A
G
T
G
C
T
T
G
G
G
G
G
G
A
T
A
G
A
G
G
T
A
G
G
C
G
G
C
C
A
G
C
G
G
G
G
G
C
A
G
C
G
T
C
A
G
G
G
C
G
C
A
G
A
G
C
A
T
0.001957
0.013699
0.035225
0.001957
0.013699
0.041096
0.017613
0.019569
0.023483
0.056751
0.052838
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0.011742
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0.019569
0.043053
0.086106
0.072407
0.062622
0.033268
0.013699
0.048924
0.007828
0.02544
0.031311
0.023483
0.058708
0.09002
0.027397
0.009785
0
0.027397
0
34,826
T
A
C
C
T
T
T
T
C
A
T
C
C
T
C
G
T
C
T
T
T
T
T
C
A
T
C
A
G
A
A
A
T
C
T
G
T
G
G
A
T
T
T
A
C
T
T
T
T
T
C
A
G
G
T
T
C
T
T
T
T
T
C
T
T
C
0.097847
0.023483
0.046967
0.013699
0.035225
0.035225
0.013699
0.023483
0.048924
0.031311
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0.023483
0.041096
0.046967
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0.011742
0.013699
0.015656
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0.031311
0.04501
0.02544
0.02544
0.037182
0.02544
0.017613
0.015656
0.037182
0
34,827
G
C
C
C
A
G
C
A
G
C
C
C
G
G
G
G
C
C
A
G
A
C
C
C
T
G
C
C
T
G
G
C
C
G
C
T
T
G
T
T
G
C
C
T
G
T
A
A
G
C
C
T
C
T
G
G
C
C
A
A
G
G
A
G
C
T
0.009785
0.003914
0.023483
0.005871
0.027397
0.035225
0.021526
0.015656
0.027397
0.054795
0.064579
0
0.013699
0.019569
0.019569
0.048924
0.076321
0.056751
0.093933
0.031311
0.013699
0.017613
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0.054795
0.007828
0.043053
0.043053
0.076321
0.041096
0.003914
0.005871
0.037182
0
34,828
T
T
T
T
A
G
G
C
A
A
C
G
G
G
G
T
C
T
C
T
A
T
G
C
C
C
A
A
C
A
A
C
T
T
G
G
G
C
T
G
G
T
C
A
C
A
G
G
A
G
G
T
G
C
T
G
C
A
T
G
T
C
A
C
C
A
0.029354
0.031311
0.033268
0.021526
0.041096
0.029354
0.011742
0.023483
0.033268
0.033268
0.060665
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0.039139
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0.060665
0.035225
0.056751
0.02544
0.007828
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0.017613
0.039139
0.031311
0.02544
0.060665
0.052838
0.037182
0.011742
0.015656
0.033268
0
34,829
G
T
G
G
A
C
C
T
G
G
G
C
C
T
C
C
G
A
G
A
C
T
G
G
G
A
A
C
A
G
C
C
C
G
T
C
C
A
G
G
G
A
A
C
A
G
A
C
C
A
C
G
G
T
C
C
C
C
T
G
C
G
T
G
T
T
0.007828
0.017613
0.027397
0.005871
0.035225
0.041096
0.019569
0.031311
0.04501
0.023483
0.060665
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0.011742
0.017613
0.013699
0.050881
0.068493
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0.091977
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0.013699
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0.043053
0.031311
0.048924
0.033268
0.050881
0.046967
0.009785
0.005871
0.029354
0
34,830
G
G
C
T
C
A
C
T
C
A
C
A
G
A
G
C
A
C
A
T
T
C
A
C
G
G
T
C
A
C
C
T
T
G
C
G
G
G
T
G
A
C
C
T
C
C
C
C
T
T
G
A
G
T
G
C
T
C
C
T
G
G
C
C
C
C
0.02544
0.013699
0.019569
0.023483
0.033268
0.033268
0.013699
0.029354
0.031311
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0.021526
0.033268
0.037182
0.052838
0.041096
0.015656
0.007828
0.043053
0
34,831
C
C
G
G
T
T
T
T
C
G
C
C
C
C
C
C
A
G
G
G
T
G
A
C
G
T
T
G
C
A
G
A
C
C
A
G
C
T
G
C
C
T
G
G
C
A
C
C
C
T
C
C
T
G
C
T
C
T
G
C
G
C
T
A
G
T
0.009785
0.021526
0.019569
0.007828
0.017613
0.037182
0.02544
0.023483
0.035225
0.037182
0.060665
0
0.009785
0.009785
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0.029354
0.060665
0.043053
0.086106
0.048924
0.029354
0.04501
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0.058708
0.035225
0.033268
0.029354
0.064579
0.050881
0.019569
0.003914
0.019569
0
34,832
T
G
G
A
A
C
T
C
C
C
T
C
C
A
G
T
G
T
G
A
C
C
A
G
A
G
C
T
T
G
G
G
C
C
C
C
A
G
C
T
G
C
G
C
A
G
G
T
T
A
C
T
G
T
C
A
C
C
A
T
C
T
G
C
C
T
0.003914
0.017613
0.023483
0.007828
0.019569
0.04501
0.027397
0.017613
0.029354
0.046967
0.054795
0.011742
0.015656
0.011742
0.011742
0.035225
0.060665
0.043053
0.09002
0.041096
0.031311
0.043053
0.009785
0.054795
0.027397
0.037182
0.027397
0.050881
0.04501
0.019569
0.009785
0.029354
0
34,833
A
G
C
A
G
G
G
T
G
A
A
G
C
T
G
G
G
T
T
T
A
A
C
C
T
T
C
C
T
G
A
A
T
G
G
G
G
T
C
C
A
G
G
G
A
C
A
C
T
C
C
A
C
A
T
C
T
G
C
C
A
C
A
T
A
C
0.039139
0.017613
0.035225
0.015656
0.019569
0.035225
0.009785
0.015656
0.037182
0.050881
0.066536
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0.019569
0.017613
0.023483
0.033268
0.07045
0.064579
0.076321
0.021526
0.003914
0.005871
0.017613
0.046967
0.037182
0.019569
0.039139
0.056751
0.060665
0.009785
0.007828
0.021526
0
34,834
T
C
G
G
C
T
G
C
A
T
A
G
A
C
G
T
G
A
G
G
G
G
C
A
G
A
T
A
G
G
T
G
C
T
C
T
C
C
T
C
C
C
T
A
A
C
A
T
G
G
T
A
A
C
T
G
C
C
G
C
T
C
C
G
T
G
0.011742
0.019569
0.031311
0.015656
0.02544
0.037182
0.031311
0.023483
0.035225
0.046967
0.029354
0.011742
0.021526
0.017613
0.02544
0.04501
0.050881
0.048924
0.082192
0.039139
0.011742
0.043053
0.015656
0.037182
0.021526
0.039139
0.037182
0.037182
0.043053
0.015656
0.019569
0.029354
0
34,835
G
C
A
C
C
A
C
C
G
T
G
A
G
G
C
T
G
G
T
C
C
G
G
G
G
C
G
A
C
C
C
A
T
C
C
T
C
C
A
C
T
T
G
G
C
A
G
C
G
C
A
G
G
G
T
G
A
A
G
T
T
C
T
G
G
C
0.011742
0.019569
0.02544
0.005871
0.015656
0.039139
0.015656
0.027397
0.027397
0.068493
0.048924
0.005871
0.005871
0.013699
0.011742
0.050881
0.072407
0.060665
0.074364
0.035225
0.017613
0.02544
0.009785
0.066536
0.023483
0.027397
0.043053
0.056751
0.048924
0
0.015656
0.029354
0
34,836
G
A
C
C
A
G
T
C
C
C
A
C
C
T
C
C
G
G
A
C
A
C
G
T
C
G
A
C
T
C
A
C
T
G
T
A
C
A
C
G
G
T
G
A
T
G
T
T
A
G
A
G
G
A
G
C
C
T
G
T
T
A
T
C
T
C
0.021526
0.023483
0.019569
0.021526
0.048924
0.02544
0.015656
0.037182
0.066536
0.033268
0.033268
0.013699
0.027397
0.019569
0.043053
0.04501
0.076321
0.056751
0.039139
0.009785
0.007828
0.005871
0.009785
0.064579
0.015656
0.043053
0.039139
0.037182
0.037182
0.015656
0.007828
0.039139
0
34,837
G
A
G
A
C
A
G
A
A
G
G
G
T
T
C
C
T
G
C
C
T
T
C
A
T
G
G
T
C
C
A
G
T
G
G
G
A
A
A
G
G
T
A
G
A
A
T
C
C
A
T
C
A
G
A
G
A
C
C
G
G
G
G
A
G
G
0.027397
0.031311
0.043053
0.013699
0.043053
0.031311
0.007828
0.02544
0.041096
0.029354
0.074364
0.003914
0.019569
0.02544
0.02544
0.041096
0.064579
0.041096
0.056751
0.011742
0.005871
0.009785
0.009785
0.050881
0.052838
0.02544
0.037182
0.029354
0.066536
0.009785
0.009785
0.035225
0
34,838
G
A
G
C
C
T
C
T
T
C
T
G
G
C
C
T
C
C
T
T
C
T
G
A
G
T
T
C
T
C
C
C
C
G
G
T
C
T
C
T
G
A
T
G
G
A
T
T
C
T
A
C
C
T
T
T
C
C
C
A
C
T
G
G
A
T
0.023483
0.031311
0.043053
0.011742
0.04501
0.031311
0.005871
0.02544
0.037182
0.031311
0.076321
0.005871
0.019569
0.027397
0.02544
0.041096
0.062622
0.041096
0.060665
0.011742
0.003914
0.009785
0.013699
0.050881
0.050881
0.021526
0.037182
0.031311
0.066536
0.013699
0.009785
0.033268
0
34,839
C
A
G
T
G
G
C
T
C
C
C
G
C
G
G
C
C
T
G
T
C
T
G
C
C
G
G
C
T
G
G
C
C
G
A
C
T
G
C
C
T
T
G
T
G
A
G
C
C
T
T
G
G
C
C
T
T
C
T
T
C
C
C
A
A
T
0.011742
0.015656
0.033268
0.003914
0.035225
0.037182
0.009785
0.02544
0.019569
0.04501
0.062622
0.005871
0.013699
0.023483
0.02544
0.054795
0.074364
0.074364
0.078278
0.02544
0.005871
0.015656
0.015656
0.029354
0.02544
0.029354
0.043053
0.078278
0.046967
0.007828
0.001957
0.02544
0
34,840
T
G
G
C
T
C
C
C
G
C
G
G
C
C
T
G
T
C
T
G
C
C
G
G
C
T
G
G
C
C
G
A
C
T
G
C
C
T
T
G
T
G
A
G
C
C
T
T
G
G
C
C
T
T
C
T
T
C
C
C
A
A
A
C
A
A
0.011742
0.015656
0.033268
0.003914
0.035225
0.037182
0.007828
0.02544
0.019569
0.04501
0.062622
0.005871
0.013699
0.023483
0.02544
0.054795
0.074364
0.074364
0.078278
0.029354
0.005871
0.015656
0.015656
0.029354
0.02544
0.027397
0.043053
0.080235
0.04501
0.007828
0.001957
0.02544
0
34,841
G
G
C
G
A
G
A
A
G
T
G
T
G
T
C
C
T
C
C
A
C
G
T
C
A
T
G
A
A
C
G
G
T
G
C
T
G
T
C
A
T
G
T
A
C
C
A
G
A
T
C
G
A
C
A
G
C
G
T
T
G
T
C
C
G
C
0.003914
0.013699
0.023483
0.013699
0.041096
0.035225
0.021526
0.02544
0.017613
0.041096
0.043053
0.001957
0.02544
0.056751
0.029354
0.056751
0.060665
0.066536
0.050881
0.023483
0.015656
0.021526
0.003914
0.039139
0.021526
0.035225
0.052838
0.052838
0.04501
0.017613
0
0.043053
0
34,842
G
C
C
G
A
G
T
G
G
A
A
G
T
C
T
G
T
G
G
T
C
A
T
C
C
T
G
G
T
G
C
C
C
G
T
G
C
G
A
C
T
G
G
G
T
G
G
C
G
A
G
A
C
T
C
T
C
A
A
C
C
C
C
G
T
T
0.043053
0.033268
0.023483
0.017613
0.035225
0.043053
0.017613
0.023483
0.031311
0.035225
0.056751
0.003914
0.021526
0.015656
0.039139
0.050881
0.056751
0.050881
0.062622
0.015656
0.013699
0.019569
0.019569
0.043053
0.02544
0.02544
0.037182
0.048924
0.031311
0.009785
0.009785
0.039139
0
34,843
A
G
C
G
G
A
G
G
A
A
A
C
A
A
C
A
G
G
G
G
C
C
C
A
A
G
A
A
C
A
G
C
T
C
C
T
G
A
G
C
A
C
C
A
G
G
G
A
G
C
A
G
G
C
A
G
G
G
G
C
C
T
C
A
G
C
0.015656
0.013699
0.037182
0.009785
0.031311
0.017613
0.007828
0.02544
0.037182
0.056751
0.058708
0.003914
0.027397
0.017613
0.035225
0.039139
0.072407
0.060665
0.066536
0.021526
0.007828
0.017613
0.009785
0.056751
0.021526
0.015656
0.043053
0.078278
0.04501
0.013699
0.003914
0.031311
0
34,844
T
G
A
G
C
A
G
G
A
G
G
G
A
G
A
C
T
G
G
A
G
C
C
A
G
C
A
G
G
A
G
C
T
G
C
A
C
T
G
T
G
A
G
G
A
C
C
C
C
A
A
C
T
T
C
A
A
C
G
T
A
G
G
T
A
C
0.011742
0.013699
0.039139
0.005871
0.013699
0.029354
0.035225
0.029354
0.029354
0.035225
0.058708
0.001957
0.015656
0.003914
0.02544
0.037182
0.07045
0.060665
0.105675
0.029354
0.015656
0.021526
0.005871
0.037182
0.033268
0.043053
0.031311
0.064579
0.052838
0.011742
0
0.031311
0
34,845
T
A
G
G
T
C
C
T
G
G
G
G
A
G
A
T
G
C
A
G
T
G
G
C
T
C
A
C
C
C
C
T
C
C
T
C
T
T
C
C
T
C
C
A
T
T
T
C
C
T
C
T
T
C
A
T
C
T
T
C
C
T
C
C
T
T
0.033268
0.017613
0.029354
0.023483
0.031311
0.029354
0.005871
0.02544
0.043053
0.027397
0.074364
0.013699
0.019569
0.04501
0.019569
0.033268
0.058708
0.052838
0.039139
0.007828
0.003914
0.015656
0.015656
0.066536
0.039139
0.02544
0.033268
0.041096
0.064579
0.015656
0.009785
0.039139
0
34,846
A
C
C
C
A
C
C
T
G
G
A
G
T
C
T
G
T
G
A
T
T
G
G
A
A
G
T
C
T
C
C
C
C
G
T
C
T
G
A
G
T
T
C
T
C
C
T
C
A
T
C
A
A
C
A
T
A
T
T
T
G
C
T
G
T
T
0.062622
0.023483
0.029354
0.023483
0.023483
0.02544
0.007828
0.021526
0.039139
0.04501
0.043053
0.02544
0.019569
0.033268
0.027397
0.027397
0.058708
0.054795
0.07045
0.017613
0.011742
0.013699
0.011742
0.050881
0.043053
0.02544
0.02544
0.04501
0.04501
0.001957
0.003914
0.043053
0
34,847
T
G
G
G
G
A
T
G
A
G
G
A
C
A
G
C
A
G
G
G
C
A
G
T
C
A
C
C
A
T
C
T
T
G
A
A
G
C
A
C
C
T
C
A
G
C
C
A
C
T
C
C
C
T
G
C
C
A
A
G
A
G
A
G
A
C
0.017613
0.013699
0.027397
0.009785
0.02544
0.033268
0.011742
0.035225
0.035225
0.037182
0.058708
0.011742
0.027397
0.033268
0.02544
0.043053
0.062622
0.054795
0.062622
0.019569
0.005871
0.013699
0.015656
0.062622
0.021526
0.029354
0.043053
0.039139
0.058708
0.019569
0.003914
0.041096
0
34,848
G
A
T
G
C
A
C
C
T
T
G
G
A
C
T
T
G
G
T
G
G
A
G
A
G
A
A
G
G
C
T
T
C
G
G
G
T
T
T
G
G
G
G
T
G
T
A
T
T
T
C
G
T
G
G
A
C
A
G
A
G
T
G
G
G
T
0.019569
0.015656
0.02544
0.019569
0.033268
0.050881
0.013699
0.017613
0.029354
0.041096
0.056751
0.003914
0.019569
0.031311
0.02544
0.060665
0.052838
0.062622
0.072407
0.019569
0.007828
0.017613
0.017613
0.046967
0.029354
0.023483
0.033268
0.048924
0.041096
0.015656
0.005871
0.041096
0
34,849
A
G
G
T
G
A
G
C
C
C
G
C
C
G
C
G
G
C
T
G
G
G
A
C
G
G
C
T
C
A
G
G
C
C
C
T
G
C
T
G
T
C
T
G
C
T
G
A
G
C
T
C
C
T
A
G
G
C
A
G
A
G
C
T
G
G
0.02544
0.015656
0.035225
0.019569
0.029354
0.033268
0.011742
0.013699
0.046967
0.050881
0.046967
0.011742
0.021526
0.033268
0.027397
0.037182
0.056751
0.058708
0.078278
0.013699
0.015656
0.021526
0.017613
0.046967
0.031311
0.02544
0.043053
0.04501
0.041096
0.009785
0.011742
0.023483
0
34,850
C
C
A
C
T
G
G
G
A
A
A
T
G
G
A
A
G
A
C
C
T
T
G
C
A
G
C
C
C
A
G
G
T
C
T
T
T
G
T
A
G
A
C
C
A
A
G
A
T
T
A
G
A
T
T
G
T
G
G
T
C
A
A
C
A
C
0.04501
0.027397
0.027397
0.027397
0.031311
0.043053
0.015656
0.021526
0.041096
0.037182
0.039139
0.013699
0.027397
0.027397
0.039139
0.033268
0.064579
0.068493
0.04501
0.017613
0.001957
0.015656
0.02544
0.021526
0.023483
0.033268
0.033268
0.050881
0.031311
0.017613
0.021526
0.031311
0
34,851
C
G
C
C
T
T
C
C
C
G
T
G
C
T
C
A
C
C
C
A
C
A
G
C
C
T
T
G
C
A
G
G
C
C
T
T
C
G
T
G
T
G
G
G
G
G
T
C
C
A
G
C
T
G
G
A
A
G
C
C
T
T
C
C
T
T
0.019569
0.021526
0.033268
0.005871
0.027397
0.027397
0.009785
0.023483
0.033268
0.04501
0.066536
0.015656
0.023483
0.017613
0.023483
0.041096
0.068493
0.056751
0.078278
0.021526
0.015656
0.011742
0.013699
0.052838
0.029354
0.019569
0.041096
0.066536
0.050881
0.005871
0.007828
0.02544
0
34,852
A
A
C
C
C
A
A
G
C
C
A
T
T
G
C
A
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C
C
A
G
A
T
G
A
A
T
A
A
A
T
A
T
A
T
A
A
T
0.046967
0.035225
0.037182
0.019569
0.039139
0.027397
0.015656
0.017613
0.050881
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0.046967
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0.029354
0.048924
0.052838
0.003914
0.009785
0.033268
0
34,853
C
T
G
G
G
A
G
C
T
G
T
C
A
T
C
G
A
A
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T
C
A
C
A
G
A
T
G
T
G
A
A
A
C
T
G
C
A
G
C
0.058708
0.023483
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0
34,854
A
G
T
G
C
C
C
G
C
T
G
C
A
G
C
T
A
C
C
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T
A
G
C
A
T
C
A
C
A
G
A
G
C
G
A
A
G
C
T
C
0.005871
0.011742
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0.046967
0.09002
0.041096
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0.007828
0.019569
0
34,855
C
A
G
C
G
T
G
C
G
C
T
C
C
A
C
C
C
G
C
G
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G
C
A
C
C
A
T
A
C
T
G
A
G
G
G
T
A
G
A
T
0
0.003914
0.011742
0.005871
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0.041096
0.033268
0.02544
0.013699
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0.043053
0.013699
0.035225
0.04501
0.082192
0.050881
0.011742
0
0.017613
0
34,856
C
T
C
G
C
C
A
T
C
A
C
A
T
C
C
C
A
T
C
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G
A
G
C
C
T
C
C
T
C
C
T
A
C
C
T
C
G
A
G
C
0.019569
0.017613
0.023483
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0.027397
0.041096
0.007828
0.021526
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0.086106
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0.027397
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0.068493
0.007828
0.005871
0.015656
0
34,857
T
G
C
C
C
C
C
C
A
C
A
G
G
A
A
C
C
T
G
C
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C
T
T
C
A
G
C
A
G
C
C
G
C
C
A
G
G
G
C
T
T
0.009785
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0.017613
0.033268
0.043053
0.048924
0.039139
0.031311
0.007828
0.035225
0
34,858
C
C
C
T
C
A
A
C
G
G
T
G
T
G
T
A
C
A
G
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A
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C
C
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G
A
A
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A
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C
C
T
G
G
G
T
C
T
C
T
0.015656
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0.043053
0.076321
0.041096
0.013699
0.007828
0.035225
0
34,859
G
C
A
G
G
A
T
G
A
A
G
C
C
G
T
G
G
A
A
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A
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C
G
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G
C
A
C
T
T
T
G
G
A
C
A
A
A
G
G
A
T
0.017613
0.011742
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0.031311
0.02544
0.041096
0.050881
0.027397
0.017613
0.027397
0
34,860
T
T
T
T
C
A
A
T
T
T
T
T
T
C
T
T
T
T
G
T
A
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C
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C
G
C
A
G
G
C
T
G
G
T
C
T
T
G
A
A
C
T
G
C
G
0.052838
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0.029354
0.017613
0.019569
0.031311
0
34,861
C
T
G
C
A
G
C
T
T
G
A
T
C
C
T
C
T
T
G
T
C
A
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C
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G
A
A
A
T
C
G
A
T
G
C
C
C
A
C
A
G
T
A
C
T
0.056751
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0.031311
0.039139
0.041096
0.041096
0.052838
0.011742
0
0.033268
0
34,862
C
T
G
G
C
T
C
T
G
G
A
G
T
C
C
T
G
G
A
C
C
A
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G
A
G
C
T
G
T
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C
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C
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C
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A
G
A
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C
C
T
T
G
T
C
C
G
A
G
G
A
A
G
A
G
C
C
T
A
G
G
T
0.015656
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0.027397
0.009785
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0.021526
0.037182
0.046967
0.046967
0.048924
0.021526
0.009785
0.035225
0
34,863
C
T
T
C
T
C
T
C
C
C
T
G
G
C
G
G
C
C
T
G
T
G
G
G
G
C
T
C
A
G
C
A
C
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T
C
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G
C
A
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G
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G
T
G
T
G
G
G
A
C
C
T
T
G
A
C
T
G
A
G
C
C
A
0.021526
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0.009785
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0.027397
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0.04501
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0.011742
0.027397
0.033268
0.088063
0.060665
0.078278
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0.027397
0.029354
0.046967
0.060665
0.056751
0.001957
0.001957
0.033268
0
34,864
T
G
C
T
G
A
A
A
G
G
T
G
G
C
T
G
G
G
A
G
A
G
G
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C
C
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G
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C
A
C
A
G
T
C
G
G
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G
T
C
A
G
A
G
T
C
C
C
A
G
G
A
G
G
G
G
A
G
T
G
G
A
G
0.029354
0.007828
0.02544
0.02544
0.02544
0.04501
0
0.031311
0.029354
0.021526
0.072407
0.015656
0.019569
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0.027397
0.037182
0.066536
0.048924
0.09002
0.019569
0.001957
0.005871
0.009785
0.052838
0.019569
0.046967
0.031311
0.039139
0.058708
0.009785
0.011742
0.048924
0
34,865
T
G
G
T
G
C
T
G
G
A
C
A
A
A
T
G
G
T
T
G
C
T
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C
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A
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C
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A
C
C
T
C
C
C
A
G
G
G
C
C
T
G
G
T
G
G
C
G
0.009785
0.005871
0.023483
0.005871
0.023483
0.039139
0.005871
0.023483
0.031311
0.064579
0.058708
0.011742
0.023483
0.033268
0.013699
0.043053
0.09002
0.074364
0.074364
0.011742
0.005871
0.007828
0.011742
0.052838
0.019569
0.021526
0.052838
0.058708
0.048924
0.021526
0.001957
0.029354
0
34,866
T
C
C
C
C
C
T
C
C
C
G
G
C
G
C
A
G
C
A
G
A
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C
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C
C
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C
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T
C
A
G
C
A
T
C
G
A
C
A
A
T
G
A
C
C
A
C
T
0.019569
0.005871
0.031311
0.017613
0.023483
0.027397
0.009785
0.011742
0.027397
0.066536
0.054795
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0.019569
0.023483
0.023483
0.033268
0.078278
0.052838
0.09589
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0.019569
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0.039139
0.023483
0.02544
0.050881
0.078278
0.029354
0.007828
0.007828
0.031311
0
34,867
G
G
A
C
C
A
C
C
C
T
C
A
G
G
A
T
T
T
C
C
G
A
G
A
C
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A
C
C
C
T
G
C
C
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A
T
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C
G
G
A
C
C
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G
G
G
C
A
G
T
G
T
C
C
G
A
A
C
C
T
T
T
C
T
0.068493
0.009785
0.035225
0.011742
0.027397
0.031311
0.001957
0.027397
0.054795
0.048924
0.062622
0.007828
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0.017613
0.035225
0.082192
0.048924
0.04501
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0.011742
0.009785
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0.066536
0.031311
0.031311
0.037182
0.048924
0.043053
0.011742
0.007828
0.035225
0
34,868
A
G
A
A
A
T
C
A
C
T
A
G
G
T
G
G
C
A
C
C
T
G
T
T
C
C
T
C
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G
G
A
C
G
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C
T
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G
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C
C
C
T
G
C
A
C
C
A
G
G
G
C
A
C
A
C
A
G
T
G
G
G
T
0.013699
0.017613
0.023483
0.017613
0.039139
0.043053
0.021526
0.017613
0.041096
0.019569
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0.064579
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0.029354
0.035225
0.033268
0.052838
0.048924
0.015656
0.003914
0.029354
0
34,869
G
G
A
C
C
A
C
A
C
G
G
G
G
T
A
G
T
G
G
C
C
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C
C
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C
C
A
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C
A
C
G
T
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G
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C
C
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C
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G
G
C
C
G
C
C
G
C
C
A
G
C
T
G
T
T
T
C
T
T
0.011742
0.007828
0.021526
0.007828
0.046967
0.035225
0.019569
0.023483
0.029354
0.050881
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0.078278
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0.068493
0.021526
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0.031311
0.019569
0.035225
0.037182
0.07045
0.035225
0.013699
0.001957
0.031311
0
34,870
C
A
C
T
G
T
G
T
C
C
A
G
C
A
T
A
A
A
A
A
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G
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C
C
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G
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T
C
T
T
G
A
A
G
T
G
C
A
G
G
C
G
G
T
T
0.011742
0.007828
0.029354
0.007828
0.041096
0.031311
0.021526
0.023483
0.035225
0.058708
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0.013699
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0.019569
0.031311
0.041096
0.072407
0.033268
0.015656
0.003914
0.029354
0
34,871
C
T
C
A
C
A
T
G
G
T
T
T
G
T
G
T
T
C
A
C
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A
G
A
T
G
A
A
C
G
A
C
C
C
A
T
G
A
G
G
A
T
0.066536
0.027397
0.048924
0.04501
0.060665
0.021526
0.015656
0.031311
0.050881
0.023483
0.023483
0.050881
0.021526
0.058708
0.035225
0.033268
0.029354
0.035225
0.011742
0
0.005871
0.001957
0.013699
0.037182
0.04501
0.02544
0.015656
0.009785
0.027397
0.043053
0.041096
0.043053
0
34,872
T
G
A
T
G
C
T
G
G
A
A
A
C
T
T
T
C
A
G
G
A
A
C
C
T
G
A
C
C
T
C
T
T
T
A
G
G
T
A
A
G
G
A
T
G
A
C
A
A
T
A
T
T
C
C
T
T
C
C
C
T
C
A
G
T
A
0.068493
0.02544
0.033268
0.04501
0.037182
0.02544
0.007828
0.037182
0.046967
0.023483
0.043053
0.033268
0.027397
0.039139
0.019569
0.039139
0.050881
0.041096
0.027397
0.001957
0
0.001957
0.029354
0.035225
0.056751
0.023483
0.019569
0.017613
0.04501
0.019569
0.027397
0.050881
0
34,873
C
A
T
A
T
G
C
C
T
T
G
T
G
T
C
C
A
A
T
G
T
C
A
C
C
T
C
T
G
A
T
G
T
T
C
A
T
A
T
T
A
A
A
A
G
A
T
G
A
G
T
T
A
C
C
T
A
G
G
C
C
A
A
C
T
C
0.074364
0.031311
0.068493
0.037182
0.054795
0.021526
0
0.041096
0.041096
0.017613
0.031311
0.043053
0.021526
0.054795
0.039139
0.035225
0.02544
0.035225
0.021526
0.001957
0.003914
0.001957
0.011742
0.02544
0.056751
0.02544
0.017613
0.011742
0.035225
0.02544
0.041096
0.046967
0
34,874
A
A
G
G
G
T
T
T
C
C
C
A
C
A
T
T
C
C
T
T
A
C
A
T
G
C
A
T
A
G
G
G
C
T
T
C
T
C
T
C
C
A
T
T
G
T
G
T
G
T
C
C
T
A
C
C
A
C
G
T
A
T
T
C
A
T
0.052838
0.023483
0.056751
0.035225
0.048924
0.017613
0.009785
0.031311
0.041096
0.023483
0.046967
0.035225
0.021526
0.056751
0.027397
0.04501
0.027397
0.02544
0.029354
0.003914
0.011742
0.001957
0.019569
0.039139
0.068493
0.017613
0.031311
0.017613
0.041096
0.021526
0.017613
0.052838
0
34,875
G
A
A
A
G
C
C
T
T
C
A
G
A
T
C
T
G
C
C
C
C
A
A
A
T
C
T
T
C
A
A
T
T
G
C
A
T
G
G
T
A
G
G
A
C
T
C
A
C
A
C
T
G
G
A
G
A
G
A
A
A
C
C
G
T
C
0.066536
0.023483
0.060665
0.039139
0.048924
0.017613
0.007828
0.029354
0.056751
0.015656
0.029354
0.04501
0.027397
0.056751
0.02544
0.04501
0.027397
0.035225
0.017613
0.007828
0.015656
0
0.007828
0.035225
0.072407
0.017613
0.027397
0.015656
0.039139
0.017613
0.027397
0.041096
0