row_idx
int64
f_0_ref__32
string
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string
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string
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string
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string
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f_65_alt
string
f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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G
G
G
T
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G
G
C
G
C
C
C
A
C
A
C
G
C
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C
G
G
C
C
A
C
A
A
C
T
C
C
C
G
G
G
G
C
T
T
C
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G
C
G
T
G
G
C
C
A
T
A
G
T
G
G
G
C
A
A
C
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A
C
T
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34,977
G
C
T
T
T
T
G
G
A
C
C
C
C
A
A
G
G
C
A
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C
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C
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A
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G
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C
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G
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C
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G
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34,978
C
C
C
C
A
T
A
T
T
C
C
T
T
C
C
C
T
T
C
T
C
G
T
A
C
G
T
C
A
T
G
T
C
G
G
G
C
C
A
C
C
T
C
C
T
T
G
G
T
C
A
G
G
C
C
T
A
A
C
A
G
C
T
C
T
T
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0
34,979
T
G
A
C
A
T
C
A
G
C
C
A
C
G
C
A
G
A
A
G
C
T
G
T
G
T
G
T
C
T
G
G
T
C
T
T
G
G
C
A
G
C
T
G
G
C
A
C
T
T
T
C
T
G
C
T
C
C
A
G
C
T
C
A
G
C
0.007828
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0.011742
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0
34,980
T
G
A
C
A
A
G
T
G
G
A
G
A
C
A
C
C
A
C
C
G
T
C
G
C
T
T
G
C
T
G
A
C
G
C
C
T
G
C
C
T
T
C
C
A
T
T
T
C
A
A
C
A
T
C
C
T
G
A
A
G
C
C
C
T
T
0.02544
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0.048924
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0.019569
0.037182
0
34,981
G
G
C
C
T
G
C
C
G
C
C
T
G
G
T
G
C
A
C
G
A
C
T
T
C
A
C
A
G
A
T
G
C
C
G
T
C
A
T
C
C
A
G
G
A
G
C
G
G
C
G
C
C
G
C
A
C
C
C
T
C
C
C
T
A
A
0.023483
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0.023483
0.035225
0.04501
0.052838
0.017613
0.009785
0.050881
0
34,982
G
C
T
G
G
C
A
T
G
G
G
A
A
A
C
T
G
G
G
G
G
T
T
T
C
C
T
G
G
T
A
A
C
T
G
G
A
C
T
C
C
T
A
G
C
A
A
A
C
T
C
C
C
A
A
G
G
A
T
T
C
A
G
G
T
A
0.019569
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0.003914
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0.04501
0.033268
0.023483
0.021526
0.07045
0.056751
0.015656
0.013699
0.021526
0
34,983
C
T
G
G
G
A
A
T
A
G
G
T
G
G
C
C
G
A
C
A
T
C
T
G
G
G
T
C
G
A
G
T
T
C
T
T
C
A
A
G
C
C
C
T
C
C
T
C
T
G
T
A
G
G
A
G
T
G
A
T
C
T
G
A
A
C
0.023483
0.011742
0.037182
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0.037182
0.039139
0.009785
0.037182
0.04501
0.02544
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0.013699
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0.043053
0.027397
0.056751
0.043053
0.048924
0.041096
0.007828
0.009785
0
0.021526
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0.033268
0.031311
0.031311
0.027397
0.041096
0.021526
0.017613
0.052838
0
34,984
A
A
C
G
A
T
G
A
A
G
G
G
G
A
T
G
A
T
G
G
G
A
C
C
C
A
G
C
C
A
T
A
C
C
G
T
A
A
A
G
C
C
C
T
G
G
G
A
A
T
A
G
G
T
G
G
C
C
G
A
C
A
T
C
T
T
0.021526
0.013699
0.039139
0.02544
0.039139
0.043053
0.009785
0.031311
0.048924
0.029354
0.046967
0.013699
0.027397
0.039139
0.031311
0.052838
0.048924
0.058708
0.048924
0.007828
0.009785
0
0.021526
0.046967
0.029354
0.033268
0.033268
0.031311
0.037182
0.021526
0.017613
0.041096
0
34,985
A
G
T
G
G
C
A
G
C
A
C
C
T
G
G
C
C
T
C
A
G
A
G
G
G
C
A
G
C
A
G
T
C
G
T
C
T
G
G
A
C
A
T
G
T
T
T
G
A
G
C
A
C
A
T
C
A
G
C
C
T
C
A
T
G
T
0.029354
0.017613
0.043053
0.015656
0.029354
0.02544
0.001957
0.031311
0.046967
0.039139
0.064579
0.015656
0.019569
0.043053
0.033268
0.015656
0.066536
0.056751
0.046967
0.001957
0.011742
0.003914
0.017613
0.056751
0.039139
0.041096
0.035225
0.035225
0.062622
0.013699
0.003914
0.035225
0
34,986
A
G
C
A
A
G
G
G
G
A
G
G
T
C
A
C
C
T
C
T
G
G
C
T
T
T
T
A
T
T
C
C
T
T
T
C
T
C
C
G
C
A
G
G
G
C
C
C
A
G
G
T
A
A
G
A
G
C
G
C
C
C
T
G
T
C
0.048924
0.021526
0.031311
0.017613
0.037182
0.041096
0.009785
0.021526
0.039139
0.027397
0.060665
0.007828
0.023483
0.029354
0.02544
0.048924
0.048924
0.056751
0.072407
0.013699
0.001957
0.013699
0.017613
0.050881
0.035225
0.033268
0.02544
0.019569
0.07045
0.007828
0.009785
0.031311
0
34,987
A
C
A
G
G
T
G
G
A
T
G
G
G
T
C
A
G
A
A
A
G
T
C
A
C
T
G
C
A
A
G
C
T
T
A
C
A
T
T
C
A
G
G
G
G
C
T
C
C
A
C
C
C
G
C
A
G
C
C
A
A
A
G
C
C
C
0.029354
0.027397
0.031311
0.011742
0.017613
0.037182
0.005871
0.029354
0.023483
0.037182
0.056751
0.009785
0.017613
0.035225
0.027397
0.027397
0.078278
0.056751
0.074364
0.023483
0.005871
0.027397
0.007828
0.029354
0.031311
0.031311
0.056751
0.058708
0.041096
0.003914
0.009785
0.039139
0
34,988
C
T
C
G
G
C
C
A
T
T
T
T
C
C
A
A
C
T
G
A
C
T
T
T
C
T
G
T
G
G
A
T
C
C
C
A
T
G
A
G
A
T
C
C
A
G
C
A
T
T
T
T
T
T
A
T
G
T
C
A
T
G
T
G
C
T
0.021526
0.013699
0.035225
0.011742
0.035225
0.035225
0.017613
0.013699
0.027397
0.046967
0.050881
0.013699
0.027397
0.052838
0.019569
0.052838
0.058708
0.074364
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0.015656
0.015656
0.017613
0.009785
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0.035225
0.021526
0.035225
0.068493
0.039139
0.013699
0.005871
0.039139
0
34,989
G
A
G
A
A
G
C
C
A
G
A
G
A
G
G
A
T
A
A
A
T
T
C
A
G
A
T
A
T
G
G
T
T
C
T
G
T
A
G
T
T
C
T
G
A
C
C
A
G
G
C
A
T
G
G
A
T
A
C
T
G
T
A
T
C
G
0.029354
0.046967
0.031311
0.033268
0.050881
0.029354
0.005871
0.029354
0.064579
0.029354
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0.043053
0.043053
0.037182
0.033268
0.064579
0.052838
0.019569
0
0.005871
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0.04501
0.019569
0.029354
0.019569
0.029354
0.015656
0.029354
0.046967
0
34,990
A
C
A
A
G
A
A
G
A
G
G
T
A
C
A
T
G
G
G
T
G
T
G
T
G
G
A
G
T
C
T
G
C
G
T
T
C
A
A
T
C
C
A
A
A
C
T
G
T
G
G
C
C
A
T
G
A
T
A
A
G
A
A
G
G
T
0.021526
0.037182
0.035225
0.021526
0.050881
0.031311
0.007828
0.027397
0.058708
0.033268
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0.015656
0.039139
0.060665
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0.04501
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0.023483
0
0.003914
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0.041096
0.046967
0.017613
0.035225
0.029354
0.031311
0.017613
0.017613
0.050881
0
34,991
T
T
A
T
G
G
C
A
T
T
C
T
T
C
A
G
C
T
C
C
T
T
G
T
T
C
C
T
T
A
G
A
C
T
G
A
A
A
A
T
G
A
T
T
G
G
G
C
T
G
A
G
G
A
A
G
G
G
G
G
T
G
A
A
G
T
0.056751
0.023483
0.04501
0.033268
0.04501
0.029354
0
0.023483
0.031311
0.027397
0.062622
0.048924
0.029354
0.04501
0.037182
0.037182
0.035225
0.039139
0.033268
0.003914
0
0
0.031311
0.033268
0.039139
0.011742
0.023483
0.041096
0.035225
0.02544
0.02544
0.046967
0
34,992
T
G
C
T
G
G
T
G
G
T
G
G
C
C
A
A
A
G
G
C
G
T
G
G
G
C
T
T
G
G
T
G
T
G
T
A
T
C
A
C
G
G
C
C
C
T
G
C
T
G
G
G
C
T
G
T
T
T
T
C
T
C
C
T
C
G
0.017613
0.011742
0.039139
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0.033268
0.064579
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0.072407
0.04501
0.072407
0.043053
0.023483
0.011742
0.011742
0.009785
0.043053
0.029354
0.021526
0.037182
0.07045
0.041096
0.011742
0.003914
0.037182
0
34,993
C
A
C
G
G
C
C
C
T
G
C
T
G
G
G
C
T
G
T
T
T
T
C
T
C
C
T
C
A
T
C
C
T
C
C
T
C
T
C
C
T
A
T
G
C
C
T
T
C
A
T
C
G
T
G
G
C
C
G
C
C
A
T
C
T
C
0.017613
0.013699
0.04501
0.005871
0.033268
0.048924
0.021526
0.007828
0.031311
0.035225
0.07045
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0.029354
0.037182
0.02544
0.068493
0.046967
0.066536
0.035225
0.021526
0.011742
0.009785
0.005871
0.046967
0.035225
0.021526
0.033268
0.066536
0.04501
0.007828
0.003914
0.04501
0
34,994
C
C
T
C
A
T
C
C
T
C
C
T
C
T
C
C
T
A
T
G
C
C
T
T
C
A
T
C
G
T
G
G
C
C
G
C
C
A
T
C
T
T
G
A
A
G
A
T
C
C
C
T
T
C
T
G
C
T
G
A
A
G
G
T
C
A
0.019569
0.009785
0.052838
0.005871
0.031311
0.050881
0.015656
0.009785
0.035225
0.033268
0.068493
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0.021526
0.011742
0.007828
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0.043053
0.041096
0.023483
0.031311
0.064579
0.04501
0.005871
0.001957
0.04501
0
34,995
C
C
T
C
C
A
C
A
C
G
C
C
C
A
T
G
T
A
C
C
T
C
T
T
C
C
T
G
T
G
C
G
C
C
C
T
C
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C
C
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T
C
T
C
C
G
A
G
A
T
C
C
T
C
T
A
C
A
C
C
G
T
G
G
T
0.003914
0.013699
0.023483
0.005871
0.033268
0.029354
0.023483
0.013699
0.039139
0.060665
0.048924
0
0.027397
0.048924
0.007828
0.04501
0.074364
0.056751
0.043053
0.023483
0.015656
0.039139
0.007828
0.052838
0.033268
0.023483
0.046967
0.056751
0.043053
0.017613
0.001957
0.039139
0
34,996
C
A
T
C
A
G
C
T
G
G
A
G
G
T
G
G
G
G
G
A
A
G
A
C
A
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A
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A
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C
C
G
A
C
G
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G
A
T
G
A
A
T
T
G
G
G
T
C
A
C
T
G
T
G
G
A
G
T
G
A
T
G
0.023483
0.019569
0.02544
0.019569
0.031311
0.035225
0.015656
0.023483
0.041096
0.039139
0.050881
0.011742
0.029354
0.043053
0.021526
0.035225
0.064579
0.054795
0.039139
0.015656
0.013699
0.02544
0.009785
0.054795
0.033268
0.023483
0.037182
0.039139
0.046967
0.027397
0.009785
0.039139
0
34,997
A
G
A
G
G
G
G
C
C
C
C
G
C
A
C
C
T
C
A
G
G
G
T
C
C
G
G
C
C
A
C
A
C
A
G
C
T
G
G
G
T
T
G
T
G
A
T
G
G
G
T
T
C
C
G
A
A
A
A
C
A
C
T
G
A
T
0.02544
0.019569
0.031311
0.007828
0.041096
0.043053
0.005871
0.015656
0.048924
0.023483
0.074364
0.005871
0.021526
0.031311
0.029354
0.039139
0.052838
0.04501
0.076321
0.02544
0.005871
0.009785
0.007828
0.07045
0.02544
0.041096
0.023483
0.041096
0.058708
0.005871
0.003914
0.043053
0
34,998
T
G
T
C
C
C
A
G
C
T
G
A
G
C
C
T
G
T
C
C
T
G
G
C
T
G
G
G
C
C
T
C
T
G
G
C
C
A
G
T
G
G
C
A
G
C
A
T
C
C
C
C
T
T
G
G
C
T
G
C
T
C
C
T
C
G
0.021526
0.017613
0.027397
0.001957
0.017613
0.037182
0.013699
0.02544
0.029354
0.035225
0.080235
0.001957
0.017613
0.02544
0.015656
0.029354
0.076321
0.076321
0.080235
0.021526
0.005871
0.005871
0.017613
0.046967
0.021526
0.033268
0.033268
0.074364
0.066536
0.013699
0.009785
0.019569
0
34,999
C
A
G
A
G
G
T
G
A
C
C
T
C
T
C
C
T
T
G
A
T
G
T
T
C
T
C
T
T
G
G
T
C
G
A
A
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C
G
G
A
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G
G
T
C
G
T
A
G
A
C
C
T
G
C
A
G
G
T
G
A
G
T
0.031311
0.02544
0.037182
0.011742
0.029354
0.058708
0.003914
0.019569
0.054795
0.011742
0.076321
0.001957
0.017613
0.031311
0.033268
0.035225
0.052838
0.062622
0.074364
0.009785
0.007828
0.001957
0.011742
0.060665
0.035225
0.041096
0.02544
0.031311
0.058708
0.007828
0.005871
0.033268
0
35,000
A
C
T
T
C
A
C
A
G
A
T
G
C
C
G
T
C
A
T
C
C
A
G
G
A
G
C
G
G
C
G
C
T
G
C
A
C
C
C
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C
C
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A
C
T
C
A
G
G
G
T
A
T
T
G
A
T
G
A
T
T
T
C
C
0.031311
0.015656
0.054795
0.027397
0.02544
0.021526
0.005871
0.035225
0.052838
0.043053
0.043053
0.023483
0.029354
0.037182
0.039139
0.035225
0.056751
0.041096
0.023483
0.009785
0.001957
0.013699
0.015656
0.046967
0.04501
0.023483
0.052838
0.031311
0.041096
0.013699
0.013699
0.048924
0
35,001
C
T
G
A
G
C
C
A
C
C
A
G
C
C
C
A
G
G
T
A
C
A
G
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C
C
A
C
A
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A
T
G
G
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C
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G
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C
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C
G
G
G
G
G
C
T
C
A
T
G
A
G
C
A
C
A
T
T
G
C
0.027397
0.021526
0.035225
0.013699
0.060665
0.031311
0.007828
0.017613
0.04501
0.031311
0.037182
0.011742
0.046967
0.076321
0.027397
0.064579
0.046967
0.062622
0.035225
0.003914
0.005871
0.005871
0.011742
0.037182
0.037182
0.021526
0.027397
0.041096
0.027397
0.009785
0.005871
0.064579
0
35,002
A
A
T
G
A
T
T
G
G
G
C
T
A
A
G
G
A
A
G
G
G
G
G
T
G
A
A
G
A
C
A
G
T
A
T
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G
G
T
G
G
T
G
G
C
C
A
T
C
A
A
G
G
C
G
T
C
A
C
T
G
T
A
C
A
C
0.050881
0.019569
0.04501
0.033268
0.058708
0.023483
0.007828
0.021526
0.029354
0.031311
0.052838
0.048924
0.035225
0.04501
0.031311
0.052838
0.035225
0.037182
0.02544
0.005871
0.001957
0.007828
0.027397
0.027397
0.039139
0.015656
0.015656
0.039139
0.033268
0.023483
0.02544
0.052838
0
35,003
A
A
G
G
A
T
C
C
C
G
C
A
A
A
C
G
T
G
G
A
T
T
A
C
G
A
G
G
A
T
C
T
C
T
T
C
C
T
C
T
A
C
T
C
C
A
A
C
G
C
A
G
T
G
G
C
C
G
A
G
G
A
A
G
C
T
0.033268
0.015656
0.041096
0.021526
0.023483
0.033268
0.013699
0.019569
0.039139
0.037182
0.076321
0.019569
0.023483
0.017613
0.019569
0.039139
0.054795
0.041096
0.052838
0.015656
0.007828
0.013699
0.031311
0.04501
0.037182
0.019569
0.04501
0.04501
0.054795
0.017613
0.021526
0.023483
0
35,004
T
G
A
G
C
T
G
C
T
G
C
G
A
C
C
C
G
A
G
C
T
G
G
A
T
G
C
G
C
C
G
C
T
G
G
G
G
C
C
C
G
C
A
C
T
G
C
A
C
G
G
C
C
G
C
T
T
T
C
T
G
C
T
G
G
C
0.001957
0.007828
0.011742
0.003914
0.013699
0.027397
0.019569
0.005871
0.005871
0.046967
0.029354
0.001957
0.005871
0.015656
0.007828
0.019569
0.048924
0.029354
0.107632
0.129159
0.031311
0.138943
0.005871
0.021526
0.013699
0.033268
0.033268
0.136986
0.021526
0.005871
0.001957
0.015656
0
35,005
C
C
A
G
T
G
T
T
G
A
G
C
A
G
A
G
A
G
C
T
G
G
T
C
A
G
A
G
G
C
A
G
T
G
C
A
T
C
G
C
A
G
A
G
A
G
A
C
A
T
T
A
A
T
A
A
G
G
G
A
A
T
C
C
T
C
0.058708
0.027397
0.039139
0.019569
0.031311
0.031311
0.007828
0.029354
0.043053
0.033268
0.050881
0.013699
0.027397
0.02544
0.027397
0.041096
0.056751
0.046967
0.064579
0.005871
0.009785
0.011742
0.013699
0.046967
0.033268
0.023483
0.039139
0.027397
0.04501
0.007828
0.027397
0.033268
0
35,006
A
C
A
T
C
A
A
G
C
C
G
T
G
C
C
T
C
T
G
G
C
A
G
A
A
G
G
T
C
T
G
G
C
A
C
T
T
C
A
G
G
G
T
A
G
G
C
A
G
T
G
C
T
C
T
G
C
A
G
G
G
C
T
T
C
A
0.07045
0.017613
0.035225
0.023483
0.019569
0.017613
0.011742
0.035225
0.052838
0.039139
0.050881
0.017613
0.021526
0.019569
0.029354
0.029354
0.056751
0.043053
0.033268
0.013699
0.013699
0.015656
0.019569
0.066536
0.029354
0.017613
0.048924
0.04501
0.043053
0.019569
0.017613
0.02544
0
35,007
T
T
G
A
A
G
A
C
T
G
C
G
C
C
C
T
T
A
G
G
A
T
G
G
T
G
G
A
C
C
G
G
C
T
C
G
C
G
G
A
T
G
G
C
T
G
C
C
T
G
G
A
C
G
C
T
G
A
T
G
C
C
C
A
G
T
0.011742
0.023483
0.035225
0.013699
0.027397
0.048924
0.019569
0.021526
0.035225
0.04501
0.050881
0.005871
0.023483
0.023483
0.037182
0.050881
0.052838
0.060665
0.04501
0.027397
0.003914
0.023483
0.011742
0.052838
0.023483
0.037182
0.033268
0.039139
0.050881
0.005871
0.011742
0.046967
0
35,008
G
C
T
C
A
T
T
T
G
T
G
A
C
G
T
C
C
C
C
A
G
C
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C
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C
G
G
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C
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C
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G
T
C
T
T
G
T
G
C
C
C
C
A
G
C
A
G
C
C
T
T
G
G
C
A
T
0.015656
0.011742
0.029354
0.005871
0.02544
0.031311
0.019569
0.017613
0.039139
0.060665
0.050881
0.007828
0.019569
0.029354
0.02544
0.037182
0.086106
0.068493
0.052838
0.02544
0.011742
0.013699
0.005871
0.04501
0.021526
0.035225
0.060665
0.066536
0.046967
0.009785
0
0.023483
0
35,009
A
T
G
G
C
A
T
C
A
T
G
G
C
T
G
T
G
T
G
G
G
A
C
A
T
G
G
A
A
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C
A
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C
A
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G
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A
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C
A
C
A
T
G
C
T
A
A
C
T
G
G
A
C
A
C
A
C
A
G
0.035225
0.02544
0.039139
0.02544
0.050881
0.021526
0
0.031311
0.041096
0.04501
0.029354
0.021526
0.033268
0.048924
0.037182
0.052838
0.060665
0.062622
0.04501
0.001957
0.001957
0.003914
0.017613
0.031311
0.037182
0.017613
0.04501
0.035225
0.037182
0.007828
0.015656
0.041096
0
35,010
A
T
T
T
C
T
C
C
T
G
G
C
C
A
G
A
G
A
G
T
A
A
G
T
T
C
C
A
C
A
A
G
T
G
C
A
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C
G
T
G
T
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A
T
C
C
T
T
T
G
A
A
G
C
A
G
A
G
T
T
G
G
C
G
C
0.072407
0.02544
0.037182
0.050881
0.041096
0.027397
0.001957
0.019569
0.035225
0.031311
0.048924
0.031311
0.023483
0.039139
0.04501
0.029354
0.046967
0.048924
0.035225
0.001957
0.001957
0.005871
0.009785
0.043053
0.039139
0.011742
0.029354
0.033268
0.039139
0.023483
0.029354
0.041096
0
35,011
T
T
T
C
A
T
T
T
C
C
C
T
G
G
G
C
A
C
T
T
T
C
T
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A
C
T
C
C
A
A
G
T
C
C
T
G
G
G
G
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G
C
T
C
C
T
G
C
A
G
C
T
G
C
A
A
C
T
A
G
C
T
C
C
A
0.078278
0.023483
0.04501
0.039139
0.029354
0.031311
0.003914
0.027397
0.046967
0.035225
0.037182
0.021526
0.02544
0.037182
0.033268
0.035225
0.054795
0.054795
0.039139
0.003914
0.001957
0.001957
0.011742
0.035225
0.043053
0.021526
0.037182
0.027397
0.037182
0.011742
0.029354
0.039139
0
35,012
G
G
G
C
A
G
C
G
C
C
A
G
G
G
C
C
A
G
C
A
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C
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T
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C
A
G
C
A
G
C
A
T
G
G
T
G
G
A
G
G
G
C
A
T
0
0.001957
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0.125245
0.023483
0.007828
0
0.021526
0
35,013
T
G
T
G
G
G
C
C
C
C
C
A
C
C
A
C
C
C
G
G
C
C
A
C
T
A
T
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T
C
T
C
T
G
A
G
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C
C
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T
C
T
G
G
C
C
C
C
A
T
C
T
G
T
G
G
A
A
C
C
0.019569
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0
35,014
T
G
A
C
A
A
A
G
C
G
A
G
G
C
A
C
T
T
C
C
T
G
G
A
G
T
C
T
G
C
T
G
C
G
C
C
C
C
T
G
G
C
C
A
T
G
G
A
C
C
C
T
T
A
T
A
G
C
T
G
T
G
C
C
C
T
0.052838
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0
35,015
C
T
G
G
G
T
T
T
T
C
T
G
A
A
G
A
T
A
C
T
T
C
A
A
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A
C
A
A
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A
C
G
T
T
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C
A
A
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G
T
G
G
A
T
C
A
T
G
T
T
C
T
G
C
T
C
T
C
T
0.019569
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0.041096
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0
35,016
G
A
G
C
C
T
G
G
T
G
G
C
A
G
T
G
G
C
T
C
C
T
T
C
C
A
G
G
C
A
C
C
C
C
C
C
C
A
G
G
T
A
A
C
G
G
C
T
T
A
T
A
C
A
T
T
G
A
G
C
A
A
G
G
T
A
0.019569
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0.037182
0.029354
0.02544
0.046967
0.037182
0.007828
0.019569
0.035225
0
35,017
C
A
A
G
G
G
G
G
A
C
C
A
T
G
C
T
G
G
G
G
G
T
C
A
C
G
G
C
C
A
G
A
T
G
A
A
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A
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A
G
G
T
C
A
C
A
C
A
C
A
C
G
T
C
G
A
C
C
T
C
A
G
C
T
C
0.019569
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0.029354
0.021526
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0.013699
0.017613
0.054795
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0.037182
0.023483
0.011742
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0.046967
0
35,018
C
T
G
C
C
T
C
T
G
C
A
C
G
G
G
G
G
T
G
G
A
G
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C
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C
G
A
A
C
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C
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C
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C
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C
C
C
G
T
C
C
A
C
A
C
T
G
G
T
C
A
C
C
A
T
0.017613
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0.027397
0
0.029354
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0.023483
0.033268
0.019569
0.043053
0.052838
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0.064579
0.060665
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0.013699
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0.023483
0.039139
0.037182
0.039139
0.060665
0.007828
0.003914
0.041096
0
35,019
G
C
G
A
C
C
T
G
C
T
G
G
C
T
C
C
C
G
T
C
C
A
C
A
C
T
G
G
T
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A
C
C
A
T
G
G
C
C
C
A
G
A
T
G
C
T
G
A
C
C
C
T
G
C
C
C
C
G
G
A
A
G
T
G
T
0.017613
0.017613
0.027397
0.001957
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0.04501
0.02544
0.031311
0.021526
0.041096
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0.066536
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0.013699
0.011742
0.011742
0.04501
0.021526
0.041096
0.043053
0.037182
0.058708
0.009785
0.003914
0.039139
0
35,020
G
G
A
T
C
A
T
G
T
C
C
C
T
C
A
C
G
C
A
G
A
T
G
T
C
G
A
A
G
T
C
C
C
G
G
G
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G
C
C
G
A
G
G
A
T
C
T
G
G
A
G
G
G
A
G
G
A
A
A
A
A
C
A
C
T
0.011742
0.015656
0.031311
0.003914
0.031311
0.039139
0.021526
0.02544
0.027397
0.035225
0.052838
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0.029354
0.033268
0.02544
0.050881
0.058708
0.064579
0.072407
0.031311
0.013699
0.011742
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0.046967
0.023483
0.041096
0.041096
0.041096
0.068493
0.009785
0.001957
0.031311
0
35,021
T
A
C
C
T
T
T
G
G
G
A
A
A
C
C
T
G
T
G
G
C
T
G
G
T
G
C
C
T
T
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A
T
G
A
T
C
A
A
C
A
T
G
A
C
T
G
T
T
A
A
T
G
G
T
G
T
A
G
G
G
T
A
C
T
C
0.043053
0.027397
0.035225
0.023483
0.046967
0.037182
0.003914
0.021526
0.027397
0.029354
0.07045
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0.029354
0.029354
0.033268
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0.062622
0.052838
0.048924
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0.007828
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0.015656
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0.02544
0.023483
0.031311
0.04501
0.04501
0.021526
0.027397
0.033268
0
35,022
G
G
A
G
A
G
T
G
C
C
C
T
C
A
G
A
G
A
A
C
C
T
T
C
C
A
G
A
A
G
G
G
T
C
A
C
C
C
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G
G
A
G
C
A
A
G
G
G
G
T
G
A
G
T
C
T
C
C
T
G
G
A
A
G
G
0.02544
0.021526
0.041096
0
0.017613
0.029354
0.017613
0.029354
0.062622
0.04501
0.056751
0
0.007828
0.011742
0.02544
0.033268
0.076321
0.058708
0.062622
0.021526
0.011742
0.011742
0.009785
0.068493
0.037182
0.037182
0.037182
0.064579
0.043053
0.001957
0
0.033268
0
35,023
C
C
C
A
A
C
C
C
C
G
G
C
A
C
T
G
C
A
G
G
G
C
G
A
G
C
C
A
G
G
C
G
T
T
G
A
G
C
C
T
G
G
C
C
A
C
T
T
C
G
G
C
G
T
G
T
G
C
G
T
A
G
A
C
A
C
0.001957
0.013699
0.027397
0
0.035225
0.039139
0.019569
0.015656
0.033268
0.04501
0.068493
0
0.003914
0.011742
0.021526
0.054795
0.088063
0.066536
0.068493
0.029354
0.017613
0.031311
0.005871
0.041096
0.019569
0.031311
0.062622
0.091977
0.033268
0.009785
0
0.011742
0
35,024
A
G
A
A
G
C
A
G
C
T
C
A
G
G
G
G
T
T
T
C
C
G
G
G
C
T
G
A
T
G
G
G
C
G
G
G
T
C
C
T
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C
G
G
G
G
G
G
C
G
T
C
G
T
G
T
C
C
C
G
C
G
C
G
C
A
0.021526
0.015656
0.011742
0.011742
0.011742
0.037182
0.029354
0.017613
0.027397
0.035225
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0.007828
0.011742
0.007828
0.015656
0.033268
0.046967
0.037182
0.109589
0.076321
0.02544
0.076321
0.011742
0.04501
0.015656
0.04501
0.039139
0.064579
0.048924
0.001957
0.007828
0.015656
0
35,025
T
C
C
G
T
G
C
C
A
G
C
C
C
C
A
G
C
C
G
G
G
A
C
C
C
C
A
C
A
A
G
G
C
A
A
A
G
A
C
C
A
A
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A
A
G
A
T
T
G
T
G
T
T
T
G
A
G
G
A
T
G
A
G
T
G
0.029354
0.015656
0.031311
0.013699
0.015656
0.02544
0.003914
0.029354
0.02544
0.033268
0.062622
0.011742
0.027397
0.017613
0.029354
0.031311
0.048924
0.048924
0.109589
0.039139
0.011742
0.019569
0.021526
0.050881
0.017613
0.019569
0.029354
0.078278
0.046967
0.007828
0.013699
0.033268
0
35,026
A
T
T
G
T
G
T
T
T
G
A
G
G
A
T
G
A
G
T
T
G
C
T
C
T
C
C
C
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G
G
C
C
C
T
C
C
T
G
G
G
C
G
C
C
A
A
G
A
A
G
C
C
T
A
T
T
G
G
A
G
C
C
A
T
T
0.029354
0.017613
0.033268
0.017613
0.023483
0.021526
0.003914
0.033268
0.02544
0.035225
0.060665
0.011742
0.029354
0.015656
0.033268
0.035225
0.052838
0.050881
0.099804
0.031311
0.009785
0.013699
0.021526
0.046967
0.019569
0.021526
0.029354
0.072407
0.048924
0.005871
0.015656
0.033268
0
35,027
A
C
T
C
A
T
G
G
A
G
G
C
T
C
A
G
C
A
G
G
C
C
G
A
G
G
A
G
G
T
G
G
C
G
G
T
G
C
T
C
G
A
A
G
C
C
A
C
T
G
C
A
A
G
G
G
C
C
C
T
G
G
G
G
A
T
0.015656
0.023483
0.035225
0.009785
0.048924
0.031311
0.005871
0.015656
0.019569
0.048924
0.054795
0.001957
0.007828
0.050881
0.037182
0.041096
0.058708
0.078278
0.080235
0.019569
0.009785
0.011742
0.005871
0.039139
0.02544
0.029354
0.037182
0.07045
0.050881
0.007828
0.003914
0.023483
0
35,028
C
C
G
T
T
C
C
C
A
C
C
G
C
A
G
C
T
G
C
T
C
C
A
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C
A
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C
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G
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C
T
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C
C
C
A
G
G
G
C
T
C
G
G
A
G
G
G
C
A
G
C
C
T
T
0.048924
0.021526
0.023483
0.015656
0.023483
0.02544
0.013699
0.02544
0.02544
0.068493
0.054795
0.009785
0.007828
0.017613
0.031311
0.033268
0.078278
0.048924
0.050881
0.02544
0.005871
0.021526
0.017613
0.054795
0.021526
0.021526
0.054795
0.058708
0.043053
0.011742
0.007828
0.031311
0
35,029
T
G
C
G
C
C
G
T
C
C
T
C
T
A
G
C
A
C
C
A
A
A
T
T
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G
G
G
T
C
C
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C
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A
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C
A
G
C
T
C
C
T
C
T
A
C
T
G
C
C
C
T
G
C
T
0.009785
0.011742
0.021526
0.007828
0.007828
0.037182
0.007828
0.013699
0.017613
0.041096
0.052838
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0.015656
0.013699
0.021526
0.02544
0.039139
0.041096
0.119374
0.084149
0.02544
0.078278
0.015656
0.046967
0.013699
0.023483
0.04501
0.09002
0.050881
0.007828
0.005871
0.005871
0
35,030
G
G
C
C
C
T
A
C
T
G
C
G
C
C
A
A
G
G
C
G
G
G
G
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C
C
C
C
A
A
C
G
C
T
C
G
G
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A
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A
T
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G
A
G
C
C
T
G
G
G
T
C
C
G
G
G
G
C
G
G
G
G
T
0.009785
0.013699
0.023483
0.009785
0.003914
0.037182
0.009785
0.017613
0.019569
0.037182
0.052838
0.005871
0.019569
0.007828
0.029354
0.02544
0.037182
0.050881
0.131115
0.07045
0.019569
0.068493
0.021526
0.046967
0.011742
0.02544
0.037182
0.080235
0.056751
0.005871
0.005871
0.007828
0
35,031
C
G
C
C
G
C
G
T
G
G
G
G
C
T
G
C
C
G
C
C
G
C
G
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C
C
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G
G
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G
C
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C
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A
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A
G
G
A
G
C
G
G
A
C
C
C
G
G
C
G
C
T
G
C
A
0.005871
0.009785
0.017613
0.001957
0.011742
0.043053
0.013699
0.015656
0.031311
0.037182
0.07045
0.001957
0.021526
0.009785
0.013699
0.019569
0.076321
0.041096
0.07045
0.066536
0.021526
0.07045
0.007828
0.050881
0.013699
0.04501
0.048924
0.074364
0.060665
0.007828
0.001957
0.017613
0
35,032
G
C
C
A
T
G
C
A
G
A
G
G
T
G
A
C
A
A
C
A
G
G
G
A
C
A
T
T
G
G
C
T
T
G
G
A
G
G
C
T
G
A
C
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C
A
G
G
A
C
C
C
C
C
C
A
G
C
C
T
C
C
C
T
G
G
0.021526
0.017613
0.015656
0.011742
0.033268
0.041096
0.011742
0.017613
0.048924
0.039139
0.064579
0.005871
0.017613
0.031311
0.02544
0.031311
0.07045
0.062622
0.07045
0.015656
0.013699
0.009785
0.011742
0.072407
0.017613
0.046967
0.027397
0.04501
0.056751
0.007828
0.001957
0.035225
0
35,033
C
C
A
C
A
G
G
C
A
G
T
G
G
C
A
G
T
C
A
G
A
A
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T
C
C
A
G
G
G
G
T
T
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C
C
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G
G
G
G
C
T
A
T
G
A
G
C
T
G
G
A
C
T
C
C
G
0.001957
0.013699
0.023483
0.009785
0.029354
0.04501
0.007828
0.031311
0.035225
0.04501
0.062622
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0.023483
0.043053
0.086106
0.072407
0.058708
0.017613
0.007828
0.001957
0.009785
0.054795
0.023483
0.046967
0.048924
0.052838
0.054795
0.009785
0
0.037182
0
35,034
C
C
C
C
C
T
C
C
C
G
C
C
A
C
C
T
C
C
T
G
G
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G
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G
G
G
C
C
A
G
C
G
C
G
T
C
T
T
C
A
T
C
T
C
0.054795
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0.056751
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0.013699
0.02544
0
35,035
A
A
G
C
A
A
G
G
G
C
A
C
T
G
C
T
A
T
G
G
A
G
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G
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G
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C
A
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C
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G
C
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C
G
T
C
G
C
C
G
G
C
G
C
T
T
G
G
G
G
G
T
T
0.027397
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0.027397
0.021526
0.035225
0.054795
0.037182
0.009785
0.005871
0.02544
0
35,036
G
C
G
C
T
G
A
C
A
G
C
G
G
A
C
C
A
A
G
C
C
G
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T
C
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C
G
A
G
G
A
T
G
C
G
G
A
T
G
A
T
G
G
T
G
T
0.005871
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0.093933
0.037182
0.011742
0
0.021526
0
35,037
A
A
G
G
C
T
C
G
C
G
G
G
A
A
T
G
A
G
T
A
T
C
A
G
C
C
G
A
G
C
A
A
C
A
T
C
A
A
A
C
G
C
A
A
G
A
A
C
A
A
G
C
A
C
G
G
C
T
G
G
G
T
C
C
G
T
0.013699
0.013699
0.02544
0.011742
0.007828
0.029354
0.021526
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0.023483
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0.058708
0.019569
0.031311
0.050881
0.082192
0.039139
0.003914
0
0.033268
0
35,038
G
G
A
G
G
G
C
C
T
C
C
G
G
G
C
T
T
G
G
G
C
C
G
G
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C
C
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C
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G
C
G
C
T
C
A
G
C
G
A
A
G
C
T
G
A
C
C
T
T
C
T
0
0.009785
0.021526
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0.005871
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0.02544
0.005871
0.013699
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0.123288
0.093933
0.033268
0.054795
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0.088063
0.02544
0.031311
0.013699
0.105675
0.09002
0.001957
0
0.011742
0
35,039
T
G
C
C
A
G
G
C
G
C
G
G
G
C
A
G
A
G
G
C
T
C
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C
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C
A
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G
G
T
G
C
A
C
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A
G
T
G
G
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C
A
C
T
G
G
A
C
C
C
C
C
C
A
A
T
G
C
G
G
C
0.005871
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0.02544
0.005871
0.023483
0.043053
0.013699
0.021526
0.043053
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0.093933
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0.021526
0.029354
0.033268
0.058708
0.04501
0.013699
0.005871
0.027397
0
35,040
C
C
G
C
C
C
G
G
G
G
A
C
C
C
G
C
C
G
C
C
T
G
G
G
G
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C
G
A
C
G
A
C
C
T
G
C
G
G
C
G
C
C
G
G
C
T
G
G
C
A
G
A
G
G
C
T
G
C
C
G
A
G
C
G
G
0.007828
0.013699
0.009785
0.02544
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0.02544
0.017613
0.037182
0.123288
0.041096
0.009785
0.009785
0.007828
0
35,041
G
C
T
G
G
A
A
G
T
T
G
C
G
G
T
C
C
A
G
C
A
C
C
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C
G
G
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C
C
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C
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G
C
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A
G
T
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G
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C
G
A
A
G
C
A
G
G
C
G
G
T
G
C
C
C
A
G
G
A
0.005871
0.015656
0.015656
0.001957
0.015656
0.041096
0.019569
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0.033268
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0
0.017613
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0.048924
0.056751
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0.060665
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0.07045
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0.058708
0.015656
0.027397
0.041096
0.074364
0.058708
0.009785
0.003914
0.019569
0
35,042
G
C
G
G
C
C
G
C
C
T
T
C
C
G
A
G
G
C
C
T
G
G
G
G
C
G
C
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G
C
A
T
C
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C
C
C
C
G
C
C
C
G
C
C
C
A
G
G
G
G
C
C
A
G
T
C
C
T
G
G
G
T
C
C
A
0.009785
0.013699
0.023483
0.001957
0.011742
0.037182
0.017613
0.013699
0.021526
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0.060665
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0.017613
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0.052838
0.072407
0.09589
0.060665
0.017613
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0.001957
0.039139
0.019569
0.023483
0.037182
0.117417
0.041096
0.001957
0.001957
0.021526
0
35,043
G
C
G
A
G
C
C
C
A
G
A
C
C
C
T
T
C
C
T
G
G
C
C
T
G
C
G
G
G
G
G
G
C
A
G
G
C
C
G
C
G
C
C
C
G
C
G
C
C
T
G
G
G
C
C
T
G
G
A
C
C
G
A
G
G
A
0.009785
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0.017613
0
0.007828
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0.029354
0.009785
0.02544
0.029354
0.058708
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0.015656
0.011742
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0.021526
0.052838
0.031311
0.109589
0.088063
0.033268
0.068493
0.015656
0.037182
0.017613
0.046967
0.041096
0.091977
0.048924
0.003914
0.003914
0.011742
0
35,044
C
T
T
C
C
T
G
C
A
G
C
T
G
G
C
T
G
A
C
C
A
G
T
G
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C
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C
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C
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C
C
C
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C
A
A
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G
T
G
A
C
C
A
G
G
C
T
G
C
C
C
A
G
A
G
G
C
T
0.019569
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0.013699
0.009785
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0.013699
0.015656
0.037182
0.048924
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0.017613
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0.02544
0.046967
0.084149
0.066536
0.068493
0.017613
0.009785
0.017613
0.007828
0.052838
0.021526
0.033268
0.046967
0.050881
0.04501
0.005871
0.001957
0.033268
0
35,045
T
C
C
C
T
C
C
T
G
T
T
C
C
C
A
T
G
G
G
A
C
C
T
C
C
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A
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C
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G
C
C
G
T
C
C
A
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A
G
T
G
C
A
G
G
A
T
A
C
A
T
C
A
T
T
G
G
C
A
C
C
A
A
T
0.023483
0.019569
0.035225
0.021526
0.039139
0.033268
0.005871
0.02544
0.041096
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0.064579
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0.037182
0.02544
0.041096
0.041096
0.050881
0.007828
0.007828
0.037182
0
35,046
A
G
T
C
T
G
G
C
T
G
C
C
T
G
G
G
A
C
A
A
G
C
C
C
C
T
C
C
T
T
C
C
C
G
C
T
C
A
G
C
C
T
C
A
G
T
T
T
C
C
T
C
A
T
C
T
G
T
A
T
A
A
T
G
G
T
0.066536
0.023483
0.031311
0.041096
0.037182
0.021526
0.007828
0.023483
0.04501
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0.064579
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0.011742
0
0.011742
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0.031311
0.015656
0.031311
0.043053
0.039139
0.023483
0.031311
0.029354
0
35,047
G
G
G
C
T
C
A
G
C
C
A
C
A
G
C
T
A
C
G
T
C
T
T
C
A
C
G
C
T
G
G
G
C
A
T
A
G
C
T
G
C
C
C
A
A
A
T
C
G
T
C
A
G
G
C
A
C
C
T
C
C
T
C
C
T
T
0.007828
0.003914
0.031311
0.001957
0.021526
0.029354
0.017613
0.013699
0.017613
0.07045
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0.013699
0.017613
0.021526
0.031311
0.074364
0.058708
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0.019569
0.02544
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0.082192
0.013699
0.039139
0.031311
0.066536
0.072407
0.007828
0.001957
0.033268
0
35,048
A
G
A
C
C
C
C
A
A
A
C
C
G
A
G
T
G
T
C
T
C
C
C
G
G
A
C
C
C
A
G
C
C
G
C
G
G
G
A
G
G
T
G
C
G
C
C
G
G
G
C
A
G
C
C
T
C
T
T
C
T
G
T
G
C
A
0.011742
0.005871
0.033268
0.003914
0.007828
0.031311
0.017613
0.009785
0.04501
0.058708
0.04501
0
0.005871
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0.021526
0.037182
0.056751
0.07045
0.107632
0.060665
0.017613
0.041096
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0.064579
0.023483
0.023483
0.035225
0.099804
0.04501
0
0
0.009785
0
35,049
C
T
C
G
G
T
A
G
A
A
G
C
A
G
G
G
G
T
C
A
A
A
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A
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G
C
C
C
G
C
A
C
G
C
C
A
G
A
C
G
T
G
C
G
G
T
0.013699
0.009785
0.039139
0.007828
0.031311
0.043053
0.011742
0.013699
0.033268
0.052838
0.054795
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0.027397
0.033268
0.048924
0.043053
0.046967
0.015656
0.003914
0.039139
0
35,050
C
A
G
C
T
C
T
T
A
C
C
T
A
G
C
G
G
G
C
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G
G
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G
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C
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T
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C
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G
C
A
G
A
G
C
C
G
G
G
A
G
G
C
A
G
C
G
A
C
0.019569
0.007828
0.041096
0.001957
0.013699
0.021526
0.005871
0.019569
0.031311
0.056751
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0.023483
0.068493
0.043053
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0.04501
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0.013699
0.054795
0.031311
0.027397
0.043053
0.084149
0.050881
0.003914
0.007828
0.019569
0
35,051
G
C
G
A
C
T
A
C
G
C
G
G
C
C
G
C
G
G
A
G
A
C
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C
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C
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C
T
G
C
T
C
C
G
A
G
G
T
G
A
G
A
C
A
C
T
C
T
0.019569
0.015656
0.019569
0.003914
0.013699
0.041096
0.015656
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0.050881
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0.117417
0.019569
0.041096
0.019569
0.033268
0.031311
0.078278
0.035225
0.009785
0.005871
0.021526
0
35,052
A
C
A
C
A
A
C
T
G
G
T
G
T
T
G
G
A
G
C
A
G
G
G
G
T
C
C
T
C
C
A
T
C
C
G
T
A
C
C
T
G
G
C
G
C
C
A
G
G
A
G
C
G
T
G
G
C
G
C
G
G
T
G
G
C
T
0.007828
0.019569
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0.04501
0.037182
0.017613
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0.052838
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0.005871
0.015656
0.046967
0.066536
0.056751
0.056751
0.050881
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0.093933
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0.013699
0.029354
0.04501
0.066536
0.043053
0.023483
0.007828
0.015656
0
35,053
C
A
C
C
A
T
G
T
A
T
T
G
G
C
C
A
G
C
C
C
G
G
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C
A
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A
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A
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T
G
A
A
T
G
G
C
A
G
C
C
T
G
T
G
G
G
C
C
C
0.011742
0.019569
0.019569
0.017613
0.033268
0.043053
0.013699
0.013699
0.04501
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0.072407
0.013699
0.009785
0.02544
0.02544
0.033268
0.076321
0.058708
0.072407
0.021526
0.007828
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0.052838
0.021526
0.031311
0.046967
0.068493
0.041096
0.017613
0.007828
0.021526
0
35,054
C
A
A
C
C
T
G
G
T
T
A
T
C
C
G
G
G
G
T
C
T
C
C
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A
C
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C
A
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C
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C
C
A
A
C
T
T
G
G
A
C
A
C
C
T
T
G
A
T
G
T
0.054795
0.023483
0.029354
0.021526
0.027397
0.04501
0.011742
0.02544
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0.037182
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0.021526
0.02544
0.031311
0.039139
0.04501
0.013699
0.021526
0.033268
0
35,055
C
T
C
C
C
C
T
G
G
G
G
C
T
G
T
G
G
G
G
C
T
C
T
A
C
G
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A
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G
G
T
G
A
C
C
T
G
G
G
T
G
G
T
C
C
C
C
C
T
0.052838
0.011742
0.043053
0.005871
0.031311
0.035225
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0.027397
0.052838
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0.033268
0.035225
0.029354
0.043053
0.050881
0.005871
0.005871
0.033268
0
35,056
G
T
C
T
C
T
T
G
G
G
C
C
C
C
C
A
A
G
G
C
G
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A
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C
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C
C
T
T
G
G
T
G
T
G
G
A
G
T
G
T
C
G
G
G
T
0.019569
0.007828
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0.013699
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0.035225
0.035225
0.07045
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0.013699
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0.017613
0.031311
0.041096
0.080235
0.043053
0.005871
0.011742
0.031311
0
35,057
C
G
A
C
A
A
G
T
A
C
C
A
G
T
A
G
T
G
C
A
G
G
A
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C
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C
G
C
A
A
A
C
A
T
G
C
T
C
G
C
T
A
T
A
A
C
0.017613
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0.017613
0.021526
0.060665
0.02544
0.023483
0.039139
0.058708
0.060665
0.021526
0.015656
0.013699
0
35,058
G
A
A
A
A
A
T
G
C
T
G
A
A
T
A
T
G
A
T
A
G
C
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G
C
T
C
C
G
C
C
A
C
C
T
T
G
A
A
C
A
C
A
T
0.031311
0.031311
0.039139
0.023483
0.029354
0.035225
0
0.027397
0.031311
0.037182
0.064579
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0.021526
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0.029354
0.056751
0.052838
0.074364
0.011742
0.001957
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0.023483
0.043053
0.043053
0.019569
0.015656
0.046967
0.048924
0.011742
0.013699
0.046967
0
35,059
C
C
C
G
A
T
G
A
G
C
A
A
A
A
G
A
G
A
C
A
C
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C
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A
C
T
C
G
G
G
T
T
C
C
T
G
T
G
T
A
A
C
T
T
0.031311
0.021526
0.027397
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0.041096
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0.023483
0.054795
0.072407
0.062622
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0.011742
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0
0.011742
0.052838
0.027397
0.035225
0.027397
0.043053
0.041096
0.009785
0.015656
0.041096
0
35,060
G
G
T
C
A
A
G
G
G
C
T
C
C
G
T
T
C
C
G
G
G
G
C
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A
A
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T
C
C
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G
T
G
C
G
G
G
G
T
C
A
G
G
G
A
T
T
C
G
G
A
A
C
G
0.015656
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0.029354
0.035225
0.043053
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0.041096
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0.029354
0.021526
0.027397
0.033268
0.052838
0.017613
0.015656
0.029354
0
35,061
C
C
A
G
C
T
C
T
T
A
C
C
T
G
T
A
A
A
G
G
G
A
G
T
A
T
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G
T
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A
T
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C
A
C
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C
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A
G
C
T
T
T
C
A
G
C
A
G
C
A
C
C
A
C
C
A
G
C
A
C
C
A
C
0.019569
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0.088063
0.062622
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0.029354
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0.041096
0
0.041096
0.023483
0.013699
0.058708
0.058708
0.046967
0.009785
0.007828
0.015656
0
35,062
C
T
G
G
G
A
C
A
C
C
T
G
G
C
G
C
A
A
C
A
A
G
G
C
G
G
T
G
G
T
G
C
C
T
C
C
C
A
G
G
C
G
G
T
C
C
G
G
G
G
A
G
C
C
A
A
T
G
G
T
G
T
C
C
A
A
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0.011742
0.033268
0.04501
0.07045
0.060665
0.009785
0.005871
0.013699
0
35,063
A
G
C
C
T
G
T
G
A
G
G
T
C
C
A
G
G
G
T
A
T
G
C
T
G
G
T
G
C
C
G
C
C
G
A
T
G
G
C
A
C
C
C
A
C
C
G
G
C
C
A
T
T
C
C
A
C
A
T
G
C
A
A
C
G
T
0.001957
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0.023483
0.011742
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0.048924
0.080235
0.052838
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0.003914
0.019569
0
35,064
G
G
G
G
C
A
G
G
G
T
G
A
C
A
G
C
C
A
T
G
T
C
T
A
C
A
G
G
C
A
C
A
T
A
C
A
C
G
T
G
A
G
G
T
G
G
C
T
T
G
T
C
C
C
C
T
T
C
C
T
C
A
G
C
A
A
0.02544
0.009785
0.031311
0.011742
0.041096
0.035225
0.005871
0.017613
0.037182
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0.02544
0.043053
0.084149
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0.07045
0.015656
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0.007828
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0.031311
0.023483
0.043053
0.037182
0.060665
0.046967
0.003914
0.003914
0.037182
0
35,065
C
G
A
G
A
A
A
A
T
C
A
A
G
A
C
T
G
G
C
A
C
C
C
A
G
A
A
A
C
A
G
G
C
G
A
A
A
A
C
A
G
A
C
A
T
G
G
C
A
T
T
T
A
A
G
A
C
C
A
G
T
G
T
G
G
T
0.02544
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0.033268
0.011742
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0.037182
0.005871
0.019569
0.027397
0.046967
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0.046967
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0.003914
0.039139
0
35,066
A
A
A
T
G
C
C
A
T
G
T
C
T
G
T
T
T
T
C
G
C
C
T
G
T
T
T
C
T
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G
G
T
G
C
C
A
G
T
C
T
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G
A
T
T
T
T
C
T
C
G
G
C
T
T
C
C
A
A
A
G
G
A
A
G
0.027397
0.015656
0.033268
0.013699
0.037182
0.037182
0.005871
0.019569
0.02544
0.046967
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0.031311
0.033268
0.068493
0.046967
0.005871
0.003914
0.039139
0
35,067
C
A
C
T
T
G
G
G
G
T
G
G
A
G
C
C
T
T
G
A
C
A
T
T
T
G
C
C
A
C
T
G
T
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G
G
A
G
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G
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C
C
A
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A
C
A
C
A
G
A
G
T
C
T
T
G
A
G
G
A
T
G
G
C
0.023483
0.021526
0.037182
0.011742
0.023483
0.052838
0.003914
0.017613
0.031311
0.04501
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0.027397
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0.066536
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0.003914
0.037182
0
35,068
G
A
C
C
C
T
G
C
C
A
C
A
G
A
C
A
T
A
T
C
C
A
G
C
G
T
C
C
A
C
G
A
T
G
A
C
C
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C
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A
C
C
C
A
A
G
A
C
T
A
G
C
C
C
A
G
T
T
C
C
0.019569
0.019569
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0.054795
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0.04501
0.027397
0.048924
0.035225
0.017613
0.007828
0.033268
0
35,069
T
C
T
C
C
G
G
A
G
C
C
C
T
G
G
C
T
T
T
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T
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T
C
T
T
C
A
C
T
G
A
G
T
C
A
C
C
C
T
C
T
G
0.015656
0.011742
0.021526
0.005871
0.02544
0.052838
0.019569
0.02544
0.046967
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0.043053
0.011742
0.003914
0.031311
0
35,070
T
G
C
A
G
G
G
T
C
C
T
C
A
T
G
C
T
G
C
C
A
G
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C
A
C
A
C
C
A
G
A
C
G
G
T
C
A
C
C
A
T
C
G
0.019569
0.019569
0.029354
0.007828
0.029354
0.048924
0.019569
0.019569
0.041096
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0.029354
0.046967
0.043053
0.04501
0.046967
0.013699
0.007828
0.031311
0
35,071
T
C
A
T
G
G
T
G
A
A
C
A
A
G
G
A
G
A
C
C
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C
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T
C
T
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C
A
G
A
C
C
C
C
A
G
T
C
G
C
0.013699
0.015656
0.031311
0.009785
0.02544
0.037182
0.013699
0.019569
0.041096
0.039139
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0.007828
0.023483
0.033268
0.021526
0.033268
0.080235
0.064579
0.066536
0.023483
0.007828
0.021526
0.003914
0.039139
0.033268
0.039139
0.043053
0.056751
0.050881
0.007828
0.003914
0.035225
0
35,072
G
C
A
T
C
C
T
C
C
A
G
C
C
C
C
C
G
C
T
C
A
C
C
C
C
A
G
T
C
T
C
C
T
G
G
A
C
A
A
A
A
T
G
G
A
G
A
A
A
G
C
G
C
C
T
C
C
A
C
A
G
C
C
C
C
C
0.015656
0.015656
0.029354
0.009785
0.027397
0.02544
0.023483
0.013699
0.031311
0.046967
0.052838
0.001957
0.029354
0.02544
0.031311
0.035225
0.064579
0.062622
0.064579
0.037182
0.013699
0.033268
0.011742
0.039139
0.021526
0.031311
0.043053
0.076321
0.052838
0.007828
0.001957
0.023483
0
35,073
C
A
G
C
A
A
C
A
C
C
A
G
G
A
G
C
A
T
C
T
G
A
G
A
G
C
C
A
T
T
C
A
C
C
G
T
C
C
T
G
A
G
T
T
C
T
T
G
C
C
C
G
G
G
C
A
T
G
G
C
T
G
T
G
C
G
0.017613
0.021526
0.017613
0.011742
0.017613
0.033268
0.013699
0.031311
0.039139
0.043053
0.046967
0.007828
0.013699
0.017613
0.017613
0.02544
0.066536
0.041096
0.07045
0.054795
0.019569
0.033268
0.017613
0.058708
0.021526
0.035225
0.048924
0.058708
0.050881
0.013699
0.013699
0.019569
0
35,074
G
C
G
C
A
A
G
T
T
T
C
C
C
G
G
G
A
C
C
C
T
C
A
G
A
G
T
T
G
C
A
C
T
C
C
G
A
A
G
A
C
T
C
C
A
G
A
T
T
C
C
G
A
G
A
G
T
T
G
C
G
G
A
A
A
A
0.015656
0.021526
0.02544
0.011742
0.011742
0.031311
0.013699
0.027397
0.04501
0.041096
0.046967
0.009785
0.02544
0.019569
0.023483
0.021526
0.064579
0.039139
0.072407
0.052838
0.019569
0.027397
0.011742
0.058708
0.02544
0.033268
0.048924
0.058708
0.050881
0.007828
0.009785
0.027397
0
35,075
G
G
C
G
C
C
G
C
A
G
A
G
C
G
C
G
T
G
C
G
C
G
C
A
A
C
G
G
G
G
A
C
C
A
C
T
G
T
C
C
G
C
T
C
G
G
G
C
C
C
G
G
G
C
G
T
T
G
C
T
G
C
C
G
T
G
0.005871
0.013699
0.021526
0.007828
0.021526
0.029354
0.043053
0.015656
0.017613
0.048924
0.023483
0
0.011742
0.015656
0.029354
0.04501
0.062622
0.037182
0.054795
0.076321
0.031311
0.09589
0.001957
0.019569
0.015656
0.048924
0.074364
0.082192
0.027397
0.001957
0
0.019569
0