Datasets:
TabBioMed
/
vep_pathogenic_coding

Dataset card Data Studio Files
xet
 Community
row_idx
int64
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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G
G
C
T
G
G
T
C
T
0.09002
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0.02544
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0.039139
0.027397
0
0.037182
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0.017613
0.019569
0.033268
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0.035225
0
35,193
C
T
C
C
G
G
A
A
C
C
G
C
C
G
C
G
C
G
C
C
G
G
G
G
A
C
C
C
C
G
C
T
C
C
C
C
G
C
G
G
C
T
C
A
G
T
C
C
G
T
C
C
G
C
C
C
C
G
G
C
C
T
C
G
G
T
0.001957
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0.005871
0
0
0.023483
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0.062622
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0
0.005871
0.005871
0
0.011742
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0.04501
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0.027397
0.02544
0.146771
0.050881
0.003914
0
0.007828
0
35,194
G
C
A
G
C
T
C
A
G
C
A
C
T
T
C
C
G
G
A
C
T
C
C
T
A
G
G
A
A
C
T
T
C
C
A
G
T
C
C
C
A
G
A
A
G
G
C
A
G
G
G
G
G
A
G
A
G
G
C
C
T
G
G
C
G
T
0.056751
0.021526
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0.04501
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0.041096
0.029354
0.027397
0.039139
0.035225
0.050881
0.02544
0.02544
0.02544
0
35,195
C
C
A
T
T
G
T
T
A
C
T
G
G
T
T
G
G
G
G
T
G
A
A
T
C
T
T
C
A
T
C
A
T
A
A
A
T
A
T
C
C
T
T
C
T
T
T
G
T
T
G
A
T
A
A
T
T
C
C
T
T
G
T
T
T
C
0.18591
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0.074364
0.033268
0.011742
0
0.031311
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0.017613
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0.054795
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0.02544
0.046967
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0
0.001957
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0.080235
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0.017613
0.001957
0.021526
0.011742
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0.050881
0
35,196
G
C
T
T
C
T
C
T
C
C
T
G
T
A
T
G
A
A
T
T
C
T
C
C
A
G
T
G
G
C
G
A
C
T
G
A
G
G
A
T
T
G
A
C
T
G
T
T
T
G
C
C
A
A
A
G
G
C
T
T
T
C
C
C
A
T
0.07045
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0.052838
0.052838
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0.058708
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0.064579
0.019569
0.017613
0.023483
0.027397
0.019569
0.039139
0.048924
0
35,197
C
C
A
T
G
G
C
T
C
A
T
C
A
C
T
T
A
C
T
A
A
C
C
A
T
C
A
G
A
G
C
A
C
T
C
A
C
A
C
G
G
G
A
G
A
G
A
A
A
C
C
G
T
A
T
G
A
A
T
G
T
A
T
G
A
T
0.04501
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0.050881
0.041096
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0.017613
0.027397
0.027397
0.027397
0.023483
0.056751
0
35,198
A
G
T
G
A
C
A
T
T
T
G
A
G
G
A
T
G
T
G
G
C
C
A
T
A
G
C
C
T
T
C
T
C
C
C
A
G
C
A
G
G
A
G
T
G
G
G
A
G
A
G
T
C
T
G
G
A
C
T
C
T
T
C
C
C
T
0.048924
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0
0.023483
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0.048924
0.011742
0.031311
0.017613
0.046967
0.02544
0.029354
0.037182
0
35,199
T
T
G
A
G
T
C
T
T
G
A
C
A
A
A
G
G
G
T
C
T
T
T
C
C
A
T
A
T
T
C
C
T
G
A
C
A
T
T
C
A
C
G
T
G
G
T
T
T
C
T
G
T
C
T
A
C
T
T
A
T
T
T
T
C
C
0.133072
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0
0.023483
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0.064579
0.013699
0.015656
0.015656
0.017613
0.021526
0.037182
0.050881
0
35,200
G
T
G
G
C
T
T
C
T
C
A
C
C
A
G
T
G
T
G
A
A
T
T
C
T
C
C
C
A
T
G
C
T
T
A
A
C
A
A
A
G
G
C
T
G
A
G
C
C
A
C
T
G
A
T
A
A
A
G
G
C
C
T
T
C
C
0.064579
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0.052838
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0
0.001957
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0.060665
0.013699
0.013699
0.017613
0.02544
0.041096
0.02544
0.054795
0
35,201
G
T
T
G
A
A
C
A
A
G
A
T
A
T
G
A
G
G
C
A
C
G
A
C
T
G
A
A
G
G
T
T
C
T
C
C
C
G
C
A
T
T
C
C
T
T
G
C
A
T
C
C
G
T
A
G
G
G
C
T
T
T
A
T
C
T
0.027397
0.019569
0.064579
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0.062622
0.013699
0.029354
0.037182
0.039139
0.037182
0.029354
0.048924
0
35,202
T
A
C
T
A
A
A
G
G
C
C
T
T
G
C
C
A
C
A
C
T
C
C
T
T
A
C
A
T
T
C
A
T
A
G
G
G
C
T
T
C
T
C
G
C
C
A
G
T
G
T
G
A
A
G
T
C
T
T
C
C
A
T
G
T
C
0.029354
0.017613
0.060665
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0.046967
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0.017613
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0.027397
0.021526
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0.013699
0.007828
0.019569
0.033268
0.062622
0.013699
0.029354
0.033268
0.039139
0.043053
0.027397
0.052838
0
35,203
T
A
G
G
G
T
T
G
T
G
T
A
C
G
T
T
C
T
G
C
T
G
C
A
C
C
T
G
T
T
T
C
C
G
G
G
G
A
A
G
G
T
T
T
G
C
A
C
T
G
A
A
C
T
C
A
G
A
G
C
C
T
T
T
C
T
0.041096
0.031311
0.033268
0.013699
0.058708
0.031311
0.015656
0.021526
0.039139
0.023483
0.058708
0.013699
0.019569
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0.02544
0.062622
0.07045
0.041096
0.04501
0.011742
0.007828
0.003914
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0.033268
0.043053
0.021526
0.058708
0.043053
0.039139
0.011742
0.009785
0.031311
0
35,204
C
T
G
C
T
G
C
C
G
G
C
G
T
C
G
G
G
G
G
G
T
T
G
G
G
G
T
G
C
A
G
G
C
G
G
G
G
G
A
C
T
C
C
C
C
A
T
C
A
C
T
G
G
A
T
G
G
C
G
T
T
A
T
G
T
T
0.027397
0.023483
0.021526
0.001957
0.041096
0.041096
0.007828
0.015656
0.050881
0.031311
0.066536
0.001957
0.019569
0.02544
0.021526
0.035225
0.086106
0.056751
0.086106
0.015656
0.005871
0.017613
0.005871
0.050881
0.019569
0.04501
0.043053
0.048924
0.048924
0.001957
0.005871
0.029354
0
35,205
C
T
C
C
T
G
C
C
C
A
C
T
C
C
A
G
C
T
C
T
G
G
C
C
T
C
T
G
T
T
T
C
T
C
T
C
C
A
G
C
C
C
A
C
G
G
A
G
A
G
G
T
C
A
A
A
G
C
A
T
G
C
C
T
G
C
0.017613
0.017613
0.02544
0.009785
0.043053
0.037182
0.013699
0.009785
0.04501
0.058708
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0.02544
0.023483
0.043053
0.082192
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0.023483
0.029354
0.046967
0.058708
0.041096
0.011742
0.005871
0.027397
0
35,206
A
T
G
A
C
C
T
C
T
G
G
C
A
G
G
T
G
C
C
T
T
C
T
G
T
C
T
C
T
G
A
G
C
C
A
A
A
G
G
G
T
T
G
T
C
C
T
G
G
G
C
T
T
G
C
C
C
G
G
G
A
T
A
A
T
A
0.009785
0.019569
0.017613
0.007828
0.041096
0.035225
0.007828
0.011742
0.050881
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0.02544
0.017613
0.046967
0.088063
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0.021526
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0.07045
0.021526
0.019569
0.052838
0.064579
0.039139
0.009785
0.005871
0.02544
0
35,207
T
C
C
T
T
T
C
T
A
C
T
A
T
G
G
T
G
A
G
A
G
C
C
C
G
T
G
C
C
C
C
C
T
T
T
C
C
C
C
T
C
C
C
C
A
C
A
A
C
C
C
C
A
C
A
T
A
C
T
G
C
T
T
G
G
A
0.033268
0.023483
0.043053
0.017613
0.027397
0.033268
0.013699
0.02544
0.039139
0.021526
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0.054795
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0.039139
0.02544
0.035225
0.04501
0.054795
0.011742
0.009785
0.033268
0
35,208
G
G
A
G
G
G
G
A
C
C
T
C
A
G
T
G
C
C
A
G
C
C
T
G
T
G
T
C
C
T
C
T
C
C
A
T
C
T
G
T
C
C
C
C
C
C
A
T
T
C
T
C
T
T
G
A
C
A
A
A
T
A
T
A
T
T
0.035225
0.019569
0.021526
0.017613
0.035225
0.033268
0.005871
0.027397
0.037182
0.035225
0.043053
0.023483
0.02544
0.039139
0.02544
0.050881
0.058708
0.056751
0.07045
0.021526
0.007828
0.015656
0.013699
0.048924
0.021526
0.027397
0.046967
0.043053
0.04501
0.003914
0.009785
0.033268
0
35,209
C
T
G
A
A
G
G
C
G
A
A
G
T
C
G
C
T
G
C
C
T
A
G
G
A
T
G
G
C
C
A
G
C
T
G
G
T
C
C
C
T
G
G
C
G
A
T
G
A
G
C
A
G
T
G
G
C
T
G
G
A
A
G
A
C
T
0.017613
0.015656
0.037182
0
0.027397
0.031311
0.017613
0.021526
0.029354
0.052838
0.048924
0.007828
0.017613
0.029354
0.019569
0.046967
0.07045
0.07045
0.076321
0.027397
0.019569
0.021526
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0.02544
0.033268
0.043053
0.078278
0.037182
0.001957
0.007828
0.023483
0
35,210
G
T
G
G
C
A
T
A
G
A
C
A
T
C
C
T
C
G
G
C
C
T
C
G
G
G
G
A
T
G
T
C
T
G
T
G
C
G
T
C
T
C
T
C
G
A
A
G
C
G
G
C
C
A
C
C
G
G
T
C
C
A
G
T
G
C
0.011742
0.007828
0.027397
0.005871
0.027397
0.037182
0.027397
0.017613
0.021526
0.052838
0.048924
0.001957
0.009785
0.021526
0.017613
0.060665
0.062622
0.066536
0.07045
0.046967
0.019569
0.027397
0.009785
0.039139
0.017613
0.035225
0.043053
0.091977
0.035225
0.005871
0.005871
0.02544
0
35,211
C
C
C
C
A
C
A
G
G
C
G
G
G
C
A
G
C
C
A
G
C
A
C
G
A
A
G
A
G
G
C
T
C
G
G
G
C
C
C
A
G
C
A
C
C
A
G
T
G
G
C
T
T
G
C
A
G
G
A
C
A
C
C
A
C
G
0.003914
0.003914
0.023483
0.005871
0.023483
0.02544
0.019569
0.009785
0.017613
0.068493
0.062622
0
0.003914
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0.013699
0.046967
0.086106
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0.080235
0.062622
0.017613
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0.017613
0.019569
0.060665
0.119374
0.033268
0.007828
0.001957
0.013699
0
35,212
T
C
C
G
C
T
T
C
C
T
C
T
G
C
T
G
G
C
T
T
T
C
A
T
C
C
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C
C
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C
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C
C
T
G
T
C
T
T
C
T
T
G
T
T
C
T
G
T
C
T
C
C
0.017613
0.019569
0.031311
0.009785
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0.031311
0.027397
0.050881
0.056751
0.050881
0.009785
0.005871
0.019569
0
35,213
C
A
C
T
A
C
T
C
A
C
C
A
T
C
A
G
C
A
G
G
C
C
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C
T
G
G
A
G
T
T
C
T
G
T
G
T
A
G
A
C
T
G
C
C
0.066536
0.033268
0.035225
0.039139
0.035225
0.029354
0.009785
0.033268
0.056751
0.023483
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0.04501
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0.009785
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0.023483
0.041096
0.041096
0.027397
0.031311
0.029354
0.043053
0.019569
0.027397
0.019569
0
35,214
T
C
A
G
C
T
C
C
T
G
T
T
T
C
T
G
A
T
G
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A
C
C
G
G
G
A
C
A
G
C
T
G
C
C
T
G
C
A
C
T
0.023483
0.031311
0.029354
0.013699
0.035225
0.029354
0.009785
0.017613
0.035225
0.046967
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0.011742
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0.019569
0.031311
0.039139
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0.04501
0.07045
0.02544
0.019569
0.007828
0.009785
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0.033268
0.019569
0.039139
0.058708
0.039139
0.003914
0.009785
0.039139
0
35,215
C
T
T
C
T
C
A
T
C
G
A
G
C
C
T
G
A
A
G
T
T
G
T
C
A
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G
A
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T
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C
C
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T
T
A
A
C
T
G
T
G
T
G
T
T
A
T
T
G
G
T
G
C
T
0.023483
0.017613
0.021526
0.021526
0.039139
0.037182
0.015656
0.021526
0.029354
0.043053
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0.02544
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0.046967
0.076321
0.054795
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0.043053
0.021526
0.027397
0.046967
0.050881
0.04501
0.021526
0.019569
0.027397
0
35,216
G
C
C
C
A
C
T
G
C
C
A
C
A
G
C
C
C
C
A
G
T
C
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T
G
C
T
G
C
T
C
C
A
C
T
T
T
G
C
T
G
C
C
T
0.058708
0.015656
0.027397
0.031311
0.043053
0.029354
0
0.033268
0.019569
0.046967
0.041096
0.019569
0.013699
0.033268
0.035225
0.058708
0.066536
0.058708
0.052838
0.009785
0.007828
0.005871
0.009785
0.037182
0.027397
0.013699
0.054795
0.056751
0.023483
0.017613
0.011742
0.039139
0
35,217
T
G
T
T
C
C
T
G
C
T
T
C
C
C
C
C
G
G
C
C
T
C
A
C
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G
A
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C
T
C
C
A
G
G
G
T
A
T
C
C
T
C
C
A
G
G
G
T
0.003914
0.013699
0.021526
0.009785
0.039139
0.037182
0.009785
0.017613
0.021526
0.046967
0.066536
0.013699
0.015656
0.027397
0.019569
0.046967
0.072407
0.068493
0.09002
0.027397
0.007828
0.009785
0.009785
0.048924
0.021526
0.02544
0.037182
0.062622
0.062622
0.019569
0.003914
0.021526
0
35,218
T
C
G
G
T
G
G
G
G
C
C
T
G
C
A
C
T
G
T
T
C
C
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G
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G
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G
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T
G
C
C
C
T
G
T
G
A
G
G
A
C
G
G
C
C
G
C
C
0.041096
0.019569
0.031311
0.021526
0.037182
0.02544
0.017613
0.023483
0.027397
0.037182
0.043053
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0.021526
0.027397
0.031311
0.041096
0.060665
0.050881
0.064579
0.039139
0.015656
0.017613
0.001957
0.037182
0.02544
0.033268
0.041096
0.062622
0.043053
0.009785
0.015656
0.031311
0
35,219
C
A
T
T
C
T
T
C
A
G
C
T
C
C
T
C
G
A
T
C
T
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C
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A
G
C
T
G
A
G
G
G
C
C
A
G
C
G
C
C
T
T
G
T
0.031311
0.015656
0.021526
0.011742
0.017613
0.029354
0.017613
0.007828
0.029354
0.050881
0.062622
0.005871
0.019569
0.021526
0.017613
0.029354
0.068493
0.046967
0.080235
0.039139
0.019569
0.04501
0.007828
0.052838
0.015656
0.021526
0.056751
0.076321
0.043053
0.005871
0.015656
0.015656
0
35,220
C
C
C
G
C
A
G
C
T
T
C
C
G
C
C
T
G
T
G
C
G
T
C
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G
G
A
G
G
C
A
G
C
C
C
A
C
G
T
A
G
C
A
G
T
0.009785
0.015656
0.027397
0.003914
0.029354
0.037182
0.023483
0.007828
0.031311
0.048924
0.066536
0
0.011742
0.007828
0.023483
0.046967
0.07045
0.058708
0.060665
0.058708
0.001957
0.033268
0.009785
0.046967
0.017613
0.02544
0.039139
0.099804
0.046967
0.011742
0.005871
0.021526
0
35,221
A
A
G
A
C
G
A
A
C
C
A
G
T
G
A
T
T
G
C
C
G
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C
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G
T
A
T
C
C
A
T
G
G
T
G
G
T
G
G
C
C
A
C
G
0.007828
0.013699
0.029354
0.003914
0.015656
0.046967
0.015656
0.021526
0.037182
0.037182
0.07045
0.001957
0.009785
0.02544
0.015656
0.046967
0.072407
0.07045
0.074364
0.027397
0.013699
0.013699
0.009785
0.054795
0.02544
0.02544
0.054795
0.074364
0.04501
0.013699
0.005871
0.019569
0
35,222
T
G
A
G
C
A
G
G
A
G
C
A
C
G
T
C
C
A
C
G
G
C
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C
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G
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T
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C
C
C
A
C
G
A
A
G
A
C
C
A
C
C
A
G
G
G
C
C
T
0.007828
0.015656
0.029354
0.007828
0.017613
0.048924
0.017613
0.02544
0.043053
0.035225
0.054795
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0.015656
0.027397
0.017613
0.056751
0.062622
0.074364
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0.013699
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0.011742
0.054795
0.029354
0.019569
0.04501
0.072407
0.035225
0.017613
0.005871
0.027397
0
35,223
A
G
A
G
G
A
T
G
A
A
G
G
G
C
A
G
G
G
G
C
C
A
G
T
G
C
A
T
G
C
C
A
T
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G
G
C
T
G
C
C
T
C
C
A
C
C
A
T
G
C
G
G
A
A
A
G
G
C
A
G
G
A
A
C
C
0.003914
0.011742
0.02544
0.011742
0.021526
0.048924
0.017613
0.023483
0.04501
0.041096
0.052838
0.005871
0.015656
0.02544
0.015656
0.060665
0.076321
0.072407
0.04501
0.029354
0.011742
0.015656
0.007828
0.052838
0.033268
0.023483
0.050881
0.07045
0.035225
0.015656
0
0.033268
0
35,224
G
C
G
T
T
T
T
G
T
G
T
G
G
A
T
C
A
T
G
C
T
C
T
C
C
C
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G
C
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C
C
T
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G
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G
G
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G
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C
C
C
A
G
A
G
G
C
G
G
C
G
C
C
G
A
G
C
C
G
T
G
G
A
0.019569
0.021526
0.027397
0.021526
0.021526
0.046967
0.027397
0.02544
0.035225
0.046967
0.031311
0.011742
0.023483
0.021526
0.02544
0.064579
0.068493
0.066536
0.048924
0.019569
0.013699
0.021526
0.007828
0.035225
0.037182
0.023483
0.048924
0.046967
0.027397
0.011742
0.007828
0.043053
0
35,225
A
T
G
C
A
G
C
C
C
C
A
C
A
G
C
C
A
C
T
C
A
C
C
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A
A
G
C
A
C
C
A
T
T
G
T
G
G
C
C
A
G
G
C
A
C
C
C
C
C
T
G
C
C
A
G
G
A
G
C
C
G
C
G
G
C
0.019569
0.013699
0.039139
0.013699
0.023483
0.02544
0.007828
0.021526
0.056751
0.046967
0.050881
0.007828
0.021526
0.033268
0.029354
0.031311
0.078278
0.072407
0.062622
0.013699
0.007828
0.005871
0.011742
0.046967
0.029354
0.02544
0.058708
0.07045
0.041096
0.007828
0.007828
0.017613
0
35,226
C
A
C
T
G
G
A
G
T
C
A
G
G
C
A
G
G
T
T
C
C
A
G
G
C
T
T
T
G
G
C
G
T
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G
C
A
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A
T
G
C
T
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T
G
G
G
C
A
A
C
A
G
G
G
T
C
G
G
G
G
A
A
G
C
0.021526
0.011742
0.035225
0.015656
0.023483
0.015656
0.009785
0.019569
0.037182
0.048924
0.058708
0.003914
0.017613
0.029354
0.033268
0.031311
0.082192
0.078278
0.076321
0.015656
0.009785
0.011742
0.003914
0.04501
0.02544
0.021526
0.058708
0.088063
0.046967
0.003914
0.003914
0.015656
0
35,227
C
C
A
A
C
T
G
C
T
T
C
T
C
T
G
G
T
C
C
C
T
T
G
G
C
C
A
A
G
G
G
C
C
T
C
A
C
T
G
A
C
T
T
T
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G
A
G
C
C
A
G
C
T
G
C
C
C
C
T
C
C
G
G
C
A
0.017613
0.009785
0.031311
0.013699
0.023483
0.017613
0.007828
0.021526
0.04501
0.043053
0.064579
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0.009785
0.027397
0.027397
0.033268
0.082192
0.078278
0.086106
0.013699
0.009785
0.011742
0.003914
0.054795
0.02544
0.02544
0.054795
0.091977
0.046967
0.001957
0.001957
0.013699
0
35,228
A
C
C
T
T
C
T
G
C
C
A
C
C
C
A
G
C
C
T
G
C
T
C
C
C
A
A
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G
C
G
C
C
A
G
C
T
A
C
C
C
C
A
G
A
C
G
C
C
C
C
C
C
C
T
A
C
C
A
C
A
G
G
T
G
T
0.037182
0.023483
0.035225
0.015656
0.021526
0.048924
0.017613
0.02544
0.035225
0.043053
0.048924
0.011742
0.011742
0.021526
0.033268
0.039139
0.052838
0.07045
0.074364
0.011742
0.005871
0.023483
0.029354
0.035225
0.027397
0.027397
0.027397
0.046967
0.035225
0.023483
0.013699
0.02544
0
35,229
G
T
C
C
C
A
G
G
C
T
G
T
G
C
A
C
G
C
C
A
T
G
T
C
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C
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C
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G
G
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C
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G
A
A
G
A
G
C
C
T
G
A
G
A
G
T
C
G
G
G
C
T
T
0.007828
0.013699
0.013699
0
0.019569
0.035225
0.013699
0.027397
0.035225
0.027397
0.052838
0.001957
0.015656
0.009785
0.013699
0.041096
0.050881
0.052838
0.109589
0.068493
0.019569
0.052838
0.013699
0.064579
0.009785
0.035225
0.021526
0.09002
0.048924
0.007828
0.003914
0.021526
0
35,230
T
A
A
C
C
C
A
C
C
G
C
T
C
T
G
T
C
C
A
G
C
T
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A
G
A
C
C
A
T
A
T
G
G
G
T
G
A
C
A
G
C
C
G
0.021526
0.017613
0.027397
0.003914
0.019569
0.041096
0.013699
0.031311
0.041096
0.043053
0.043053
0.011742
0.019569
0.035225
0.017613
0.037182
0.07045
0.066536
0.062622
0.027397
0.015656
0.017613
0.007828
0.052838
0.02544
0.037182
0.039139
0.054795
0.043053
0.013699
0.005871
0.035225
0
35,231
G
G
T
C
A
T
G
C
T
G
A
T
A
G
C
C
A
T
G
T
A
T
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C
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G
G
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A
G
G
A
G
G
G
G
A
A
G
G
C
A
A
C
A
T
A
C
C
0.019569
0.015656
0.027397
0.001957
0.035225
0.033268
0.019569
0.009785
0.02544
0.043053
0.068493
0.011742
0.031311
0.041096
0.015656
0.046967
0.046967
0.056751
0.086106
0.021526
0.015656
0.017613
0.015656
0.054795
0.027397
0.019569
0.027397
0.052838
0.060665
0.015656
0.003914
0.031311
0
35,232
G
G
A
C
C
C
C
C
C
A
C
T
G
G
A
C
A
C
A
G
A
T
G
T
T
C
T
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G
T
C
C
C
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G
A
G
C
T
C
C
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A
G
C
G
C
C
A
C
T
C
G
C
C
C
A
T
T
C
A
G
A
T
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0
35,233
C
T
G
G
G
G
G
A
C
C
A
T
C
G
G
G
G
A
C
C
T
G
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G
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A
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C
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A
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G
G
C
A
G
C
A
A
A
G
G
G
G
A
C
C
G
T
T
C
C
C
0.023483
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0.029354
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0.005871
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0
35,234
T
C
C
T
C
C
T
G
T
T
T
A
T
T
C
T
G
C
T
C
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A
A
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A
A
G
C
C
G
A
C
C
C
C
T
A
T
C
C
C
T
A
T
C
0.013699
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0.033268
0.056751
0.082192
0.005871
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0.015656
0
35,235
C
C
A
G
T
G
T
C
G
G
G
C
C
A
A
G
G
C
C
G
A
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G
C
C
C
G
C
A
G
C
G
G
G
G
T
C
A
G
T
G
A
T
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0
0.02544
0
35,236
G
G
A
G
A
C
C
C
C
A
C
C
T
G
G
A
A
G
G
C
T
G
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C
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G
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T
G
C
C
T
G
C
T
C
A
G
C
T
G
G
A
G
A
G
A
G
G
0.009785
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0.043053
0.101761
0.052838
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0.001957
0.021526
0
35,237
T
C
A
A
A
G
T
C
T
T
C
T
G
G
C
C
T
C
C
A
G
G
G
A
A
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C
T
C
C
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C
C
C
T
T
C
T
T
A
G
C
A
G
C
C
T
C
C
T
T
G
G
G
G
A
C
C
T
A
G
G
G
G
T
0.043053
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0.050881
0.060665
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0.019569
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0
35,238
A
G
G
G
T
C
A
T
C
A
G
A
G
T
G
T
T
G
G
A
T
G
A
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G
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C
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C
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A
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C
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T
G
C
T
T
G
A
G
C
A
G
C
A
G
C
A
G
C
A
T
C
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0
35,239
T
C
C
T
C
A
G
A
C
G
G
C
C
T
C
C
T
G
T
T
T
C
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C
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A
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G
C
A
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G
G
G
G
A
G
A
G
A
G
G
G
G
A
G
A
A
G
C
A
G
T
0.013699
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0
0.011742
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0
0.017613
0
35,240
T
C
T
G
C
T
C
A
G
C
A
T
T
G
A
G
G
C
A
G
G
A
G
A
C
C
T
G
G
A
G
G
T
T
C
T
A
G
G
G
G
G
C
A
G
C
A
G
G
G
G
A
A
G
T
G
G
G
G
A
A
A
A
G
C
C
0.035225
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0
0.021526
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0
35,241
G
C
T
G
C
C
A
G
A
G
G
A
C
C
C
C
C
C
C
G
A
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G
A
G
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C
A
T
T
G
G
A
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G
C
A
G
A
A
G
C
C
C
C
C
C
A
A
G
A
G
C
G
A
A
C
C
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0.048924
0.037182
0.011742
0.011742
0.027397
0
35,242
C
A
C
T
C
T
G
G
G
A
G
A
C
A
C
G
A
G
C
T
C
G
G
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C
C
C
C
A
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C
T
C
A
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A
G
C
G
G
C
C
G
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C
C
T
G
G
C
A
C
T
C
A
T
A
C
T
C
C
G
C
G
T
T
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0.054795
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0
35,243
C
A
G
G
A
A
T
T
T
G
G
A
C
C
T
G
A
C
C
T
G
A
T
G
G
A
A
G
G
T
G
G
C
T
C
C
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T
C
C
A
A
C
A
G
G
A
C
C
C
C
A
T
C
T
C
G
G
A
A
C
C
A
C
A
T
0.015656
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0.041096
0
35,244
C
C
C
C
G
C
T
G
T
G
G
T
C
C
C
T
G
G
A
C
C
A
T
C
G
C
T
G
G
A
G
G
T
G
G
C
C
C
G
A
G
C
T
C
A
C
A
T
G
C
T
G
G
C
T
T
T
G
G
G
G
C
C
A
C
C
0.007828
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0.027397
0
35,245
G
A
C
C
C
A
G
G
G
C
A
G
C
C
G
T
G
C
C
C
A
T
T
T
C
C
C
C
A
G
G
G
C
A
T
G
G
A
G
G
T
G
A
G
A
T
A
C
A
G
A
G
T
G
G
G
T
A
C
A
G
G
A
T
G
G
0.041096
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0.027397
0.02544
0.048924
0.054795
0.041096
0.023483
0.013699
0.027397
0
35,246
T
C
T
C
C
C
T
G
T
T
C
C
G
G
C
C
C
C
C
A
C
T
C
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C
T
C
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T
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C
C
G
G
A
T
G
T
G
G
G
T
C
C
C
T
C
T
C
T
C
T
G
C
C
G
C
T
C
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0.062622
0.064579
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0
0.013699
0
35,247
C
C
T
C
C
C
G
T
T
G
C
T
C
C
T
G
T
G
C
C
T
G
C
T
G
C
C
G
C
T
G
G
C
C
C
C
T
G
C
C
T
C
A
T
C
C
C
C
A
C
C
C
C
A
G
T
C
A
G
C
C
A
C
A
C
T
0.007828
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0
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0.027397
0
35,248
G
A
G
C
A
C
T
G
C
A
A
C
G
C
C
G
G
G
T
G
C
G
G
A
G
G
C
T
G
C
A
A
C
G
G
T
G
C
C
A
G
G
A
G
C
G
G
C
A
C
C
A
G
G
C
G
C
A
G
C
T
G
C
A
G
T
0.021526
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0.021526
0.017613
0.058708
0.09589
0.031311
0.005871
0
0.021526
0
35,249
T
G
C
T
C
C
T
G
A
C
C
C
C
C
C
T
G
G
C
C
C
C
T
G
C
G
C
C
A
A
C
T
C
C
T
G
A
G
C
G
G
T
C
A
C
A
A
C
C
T
G
A
A
G
T
C
C
C
T
G
C
C
C
A
A
T
0.001957
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0.017613
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0.013699
0.02544
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0.066536
0.093933
0.035225
0.005871
0
0.015656
0
35,250
C
A
A
G
C
T
A
G
G
G
G
A
C
G
A
T
G
A
T
G
T
G
G
C
A
G
A
T
G
G
C
T
T
G
G
C
C
T
T
C
C
A
C
G
C
C
A
A
G
C
G
C
A
G
C
T
A
C
C
A
G
C
C
C
C
C
0.050881
0.011742
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0.011742
0.02544
0.021526
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0.029354
0.027397
0.029354
0.074364
0.039139
0.015656
0.001957
0.035225
0
35,251
C
G
G
T
G
A
C
G
C
C
A
G
G
C
T
G
G
G
T
A
T
C
C
A
C
G
G
G
G
G
G
C
T
G
C
A
G
G
A
G
C
C
C
A
T
C
A
C
A
G
G
C
A
C
T
T
G
A
C
A
G
G
G
T
C
A
0.003914
0.013699
0.021526
0
0.019569
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0.02544
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0.02544
0.033268
0.097847
0.054795
0.009785
0.001957
0.029354
0
35,252
C
A
G
G
G
C
T
C
A
C
T
C
C
A
G
C
G
G
G
C
A
G
G
G
C
T
G
C
C
C
T
G
T
A
A
C
A
G
A
C
C
A
A
G
T
G
C
A
C
C
T
G
G
G
G
T
A
G
A
G
A
G
A
A
G
G
0.005871
0.017613
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0.086106
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0.04501
0.048924
0.046967
0.013699
0.009785
0.02544
0
35,253
C
C
G
T
G
G
C
T
C
A
C
A
C
C
T
T
A
T
T
C
A
A
C
A
T
C
A
G
A
A
A
A
T
T
C
A
C
A
C
T
G
G
T
G
A
A
A
A
A
C
C
C
T
T
T
G
G
A
T
G
T
A
A
G
G
C
0.043053
0.021526
0.048924
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0.021526
0.031311
0.039139
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0.060665
0.031311
0.029354
0.027397
0.027397
0.017613
0.027397
0.068493
0
35,254
T
A
C
A
G
G
C
A
A
A
G
G
G
G
T
T
T
T
C
C
C
C
A
C
T
G
T
A
A
A
T
T
C
T
C
T
G
C
T
G
G
C
T
G
A
G
G
T
G
T
G
A
C
A
T
C
T
G
A
A
T
G
G
A
A
T
0.093933
0.019569
0.048924
0.058708
0.041096
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0.005871
0.02544
0.052838
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0
0.009785
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0.064579
0.005871
0.017613
0.017613
0.027397
0.031311
0.035225
0.050881
0
35,255
T
T
T
T
C
T
C
A
T
G
C
T
T
G
G
T
A
T
T
G
A
G
G
A
G
T
G
A
T
T
T
C
T
C
C
C
A
T
C
C
A
G
T
A
C
T
G
T
C
A
C
C
A
A
A
C
T
T
C
T
C
T
T
T
T
C
0.086106
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0
0
0.027397
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0.07045
0.013699
0.017613
0.007828
0.027397
0.02544
0.035225
0.060665
0
35,256
T
G
T
C
C
A
T
C
A
G
A
A
A
A
C
T
C
A
C
A
A
G
G
T
A
G
A
A
A
C
C
A
C
G
G
G
A
A
T
T
C
A
G
T
A
A
G
T
A
A
T
G
T
G
G
C
T
T
T
T
T
T
T
G
T
T
0.091977
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0.046967
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0.04501
0.017613
0.011742
0.015656
0.027397
0.039139
0.041096
0.043053
0
35,257
T
G
T
C
T
G
T
A
G
C
C
T
C
A
T
T
A
T
T
G
T
C
C
A
A
G
A
A
A
T
T
A
T
T
G
T
G
A
A
A
T
C
C
C
C
A
A
G
T
T
T
T
C
C
A
T
G
T
A
C
C
T
A
C
A
C
0.072407
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0.037182
0.062622
0.050881
0.015656
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0.064579
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0.054795
0.013699
0.023483
0.011742
0.021526
0.046967
0.043053
0.029354
0
35,258
A
T
T
C
A
T
A
G
G
G
T
T
T
T
T
C
A
C
C
A
G
T
A
T
G
A
A
T
T
C
T
C
T
G
A
T
G
T
C
G
A
G
T
A
A
G
A
T
C
T
G
A
G
C
C
A
C
A
A
C
T
A
A
A
G
C
0.062622
0.027397
0.054795
0.056751
0.048924
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0.007828
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0.017613
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0.009785
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0.015656
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0.015656
0.031311
0.072407
0.013699
0.003914
0.013699
0.021526
0.029354
0.054795
0.064579
0
35,259
C
T
T
C
T
G
C
T
C
C
A
G
G
G
C
A
T
G
C
A
C
C
A
T
G
C
G
T
G
A
G
A
T
A
T
T
C
T
A
A
T
T
A
T
A
T
A
C
A
C
G
T
T
C
A
T
A
A
A
C
A
T
A
T
G
G
0.050881
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0.017613
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0.041096
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0.02544
0.023483
0.046967
0.031311
0.031311
0.027397
0.031311
0.027397
0
35,260
C
T
T
C
T
C
T
C
A
G
A
G
T
T
C
A
T
C
C
C
T
A
A
C
C
G
T
A
C
A
T
A
T
G
C
G
A
A
A
T
C
A
T
A
C
A
G
C
T
G
A
G
A
A
A
C
C
C
T
A
T
G
A
A
T
C
0.07045
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0.076321
0.011742
0.017613
0.005871
0.021526
0.037182
0.027397
0.062622
0
35,261
A
A
T
T
T
A
A
G
A
G
G
C
C
T
T
C
T
T
T
C
A
T
T
T
A
A
T
A
T
A
C
T
T
G
G
T
G
T
C
T
C
T
C
A
C
C
T
G
T
A
T
G
A
C
C
T
C
T
C
T
T
A
T
G
T
C
0.09589
0.019569
0.054795
0.064579
0.035225
0.023483
0
0.027397
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0.029354
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0.023483
0.023483
0.019569
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0
0.003914
0
0.015656
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0.062622
0.011742
0.011742
0.011742
0.023483
0.031311
0.052838
0.048924
0
35,262
A
G
G
T
T
G
A
G
T
A
A
T
T
C
C
A
G
A
A
T
C
A
T
G
A
T
T
A
A
A
G
G
C
A
C
A
T
T
T
G
T
T
A
T
T
T
T
C
A
C
T
A
T
G
T
T
T
T
T
T
G
C
T
T
T
T
0.060665
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0.035225
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0.033268
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0.066536
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0.011742
0
0.001957
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0.060665
0.009785
0.031311
0.015656
0.043053
0.029354
0.04501
0.052838
0
35,263
T
C
C
T
C
T
G
A
T
G
C
T
G
A
C
T
A
A
T
T
T
G
T
G
A
G
C
T
G
G
A
A
C
G
A
A
A
G
G
C
T
T
T
C
C
C
A
C
A
T
T
C
C
T
T
A
C
A
T
T
T
A
T
G
A
T
0.074364
0.019569
0.050881
0.054795
0.037182
0.021526
0.011742
0.02544
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0.027397
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0.058708
0.013699
0.019569
0.013699
0.043053
0.027397
0.048924
0.052838
0
35,264
G
G
G
A
C
G
G
G
T
A
A
A
G
G
C
C
T
T
C
C
C
A
C
A
C
G
C
C
T
T
A
C
T
T
T
C
A
T
A
G
T
A
T
T
T
C
T
C
A
T
C
A
G
T
A
T
G
G
A
T
C
C
T
C
T
A
0.054795
0.017613
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0.043053
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0.054795
0.011742
0.019569
0.017613
0.039139
0.033268
0.037182
0.056751
0
35,265
T
T
A
T
C
T
G
A
T
G
A
A
G
G
C
T
C
A
G
C
T
G
T
G
T
G
T
C
A
T
A
A
C
G
A
A
A
A
G
C
C
T
T
T
C
C
A
C
A
T
T
C
C
T
T
A
C
A
T
T
T
A
T
G
G
T
0.048924
0.013699
0.050881
0.031311
0.052838
0.021526
0.015656
0.031311
0.035225
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0.058708
0.019569
0.015656
0.015656
0.04501
0.033268
0.029354
0.050881
0
35,266
G
G
C
A
C
A
C
A
C
A
T
A
G
G
G
T
T
T
C
T
C
T
C
C
T
G
T
G
T
G
A
A
C
T
G
G
C
T
G
A
T
G
C
A
C
C
A
G
G
A
G
C
T
G
A
G
A
C
T
T
G
G
A
G
G
T
0.052838
0.019569
0.04501
0.043053
0.043053
0.019569
0.001957
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0.068493
0.021526
0.031311
0.017613
0.033268
0.023483
0.017613
0.064579
0
35,267
A
G
G
T
T
T
C
T
C
T
C
C
A
G
T
A
T
G
A
A
T
T
A
T
T
T
G
A
T
G
T
G
C
A
A
T
C
A
A
G
T
G
T
G
C
C
T
T
C
T
G
A
A
T
G
A
A
G
G
C
C
A
G
T
C
T
0.048924
0.023483
0.039139
0.054795
0.052838
0.021526
0.005871
0.039139
0.048924
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0.066536
0.017613
0.027397
0.019569
0.029354
0.02544
0.02544
0.064579
0
35,268
T
T
T
C
T
C
T
C
T
A
C
T
T
T
G
A
A
C
T
T
T
C
T
T
A
T
G
T
G
T
A
A
C
G
A
G
G
T
T
G
G
A
A
T
T
A
T
T
G
C
T
G
A
A
G
A
C
C
T
T
C
C
C
A
T
T
0.035225
0.019569
0.046967
0.048924
0.04501
0.019569
0.007828
0.043053
0.050881
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0.072407
0.015656
0.035225
0.021526
0.029354
0.033268
0.013699
0.064579
0
35,269
G
T
G
T
C
T
C
T
C
T
C
C
A
G
T
A
T
G
A
A
T
T
T
T
C
T
C
A
T
G
T
A
T
A
C
T
G
A
G
A
T
C
T
G
A
G
T
T
A
T
A
A
G
G
G
A
A
A
C
C
T
T
T
C
C
A
0.068493
0.021526
0.037182
0.052838
0.054795
0.015656
0.003914
0.033268
0.052838
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0.013699
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0.072407
0.009785
0.02544
0.019569
0.031311
0.035225
0.007828
0.060665
0
35,270
A
T
T
G
A
A
C
C
T
G
G
G
A
A
G
T
C
C
A
G
G
C
T
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C
A
G
T
G
A
G
C
C
G
T
G
A
T
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G
C
A
C
C
A
C
A
G
C
A
C
T
C
C
A
G
C
C
T
G
A
G
G
A
T
T
0.078278
0.027397
0.027397
0.052838
0.050881
0.019569
0.005871
0.033268
0.029354
0.033268
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0.009785
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0.02544
0.037182
0.029354
0.015656
0.023483
0.031311
0.037182
0.035225
0.029354
0.033268
0
35,271
G
T
G
T
T
T
T
G
A
G
G
T
T
T
G
A
T
T
T
C
C
A
G
C
T
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G
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C
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C
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T
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C
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T
G
C
A
T
A
C
A
T
A
A
G
G
C
T
T
C
T
C
T
T
0.037182
0.019569
0.04501
0.019569
0.07045
0.031311
0.011742
0.02544
0.035225
0.039139
0.054795
0.011742
0.005871
0.029354
0.023483
0.076321
0.050881
0.035225
0.039139
0.009785
0.005871
0.015656
0.007828
0.050881
0.029354
0.027397
0.033268
0.039139
0.031311
0.015656
0.031311
0.041096
0
35,272
C
C
G
G
C
A
G
T
C
A
C
A
C
C
T
C
A
T
T
A
G
A
C
A
C
C
A
G
A
G
G
A
C
A
C
A
T
T
C
A
G
G
A
G
A
G
A
A
G
C
C
T
T
A
T
A
T
T
T
G
C
A
G
A
A
T
0.041096
0.015656
0.04501
0.017613
0.076321
0.023483
0.003914
0.035225
0.041096
0.031311
0.054795
0.023483
0.011742
0.033268
0.017613
0.080235
0.054795
0.031311
0.029354
0.009785
0.003914
0.001957
0.021526
0.041096
0.029354
0.027397
0.04501
0.039139
0.033268
0.015656
0.033268
0.031311
0
35,273
A
T
T
C
A
T
T
A
C
C
T
A
T
C
A
A
A
G
A
T
T
C
C
T
T
C
T
C
A
G
C
A
T
G
G
A
G
T
C
T
T
T
T
A
T
A
T
T
C
A
A
T
T
A
T
G
A
C
T
G
A
A
T
T
T
C
0.072407
0.021526
0.043053
0.074364
0.027397
0.021526
0.005871
0.037182
0.041096
0.023483
0.031311
0.043053
0.02544
0.052838
0.027397
0.019569
0.035225
0.029354
0.02544
0.001957
0.001957
0.001957
0.015656
0.039139
0.064579
0.011742
0.015656
0.005871
0.035225
0.039139
0.046967
0.062622
0
35,274
C
T
C
A
G
A
C
T
G
G
A
G
C
A
G
G
A
A
G
A
A
G
C
A
C
C
A
T
G
G
A
T
T
G
G
T
G
A
G
G
C
A
G
C
A
T
G
C
C
C
G
G
G
C
T
G
C
C
A
C
T
G
T
T
G
G
0.039139
0.02544
0.052838
0.02544
0.029354
0.037182
0.003914
0.02544
0.043053
0.043053
0.048924
0.015656
0.02544
0.035225
0.041096
0.041096
0.048924
0.052838
0.037182
0.013699
0.003914
0.001957
0.011742
0.04501
0.035225
0.017613
0.046967
0.037182
0.039139
0.011742
0.027397
0.037182
0
35,275
T
C
T
G
G
C
T
G
A
A
G
G
A
T
T
T
T
C
C
A
C
A
T
T
C
T
C
T
G
C
A
A
C
G
A
T
A
C
G
G
T
C
T
T
T
C
T
C
C
T
G
T
G
T
G
C
A
T
T
T
T
T
C
G
A
T
0.097847
0.023483
0.039139
0.046967
0.052838
0.029354
0.005871
0.023483
0.050881
0.021526
0.031311
0.021526
0.015656
0.048924
0.031311
0.04501
0.043053
0.033268
0.027397
0.007828
0.009785
0.003914
0.007828
0.037182
0.064579
0.019569
0.033268
0.015656
0.027397
0.021526
0.013699
0.048924
0