row_idx
int64
f_0_ref__32
string
f_1_ref__31
string
f_2_ref__30
string
f_3_ref__29
string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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f_65_alt
string
f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
7,891
T
T
T
T
C
C
A
G
C
G
G
G
G
C
C
G
A
T
A
T
T
T
C
C
A
G
G
G
G
A
A
C
C
A
G
G
A
A
G
A
C
C
C
T
A
T
A
A
A
A
T
A
A
A
T
G
A
G
G
A
T
G
T
T
T
A
0.101761
0.021526
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1
7,892
C
T
T
T
T
C
C
A
G
C
G
G
G
G
C
C
G
A
T
A
T
T
T
C
C
A
G
G
G
G
A
A
C
C
A
G
G
A
A
G
A
C
C
C
T
A
T
A
A
A
A
T
A
A
A
T
G
A
G
G
A
T
G
T
T
A
0.103718
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1
7,893
A
C
T
T
A
C
G
A
C
A
G
G
A
C
C
T
T
C
T
T
T
T
C
C
A
G
C
G
G
G
G
C
C
G
A
T
A
T
T
T
C
C
A
G
G
G
G
A
A
C
C
A
G
G
A
A
G
A
C
C
C
T
A
T
A
T
0.099804
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0.019569
0.048924
0.037182
1
7,894
A
A
T
G
A
G
C
A
A
T
A
C
T
T
A
C
G
A
C
A
G
G
A
C
C
T
T
C
T
T
T
T
C
C
A
G
C
G
G
G
G
C
C
G
A
T
A
T
T
T
C
C
A
G
G
G
G
A
A
C
C
A
G
G
A
G
0.099804
0.019569
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0.066536
0.039139
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0.001957
0.031311
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0.033268
0.005871
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0.001957
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0.017613
0.050881
0.021526
0.029354
0.019569
0.037182
0.019569
0.048924
0.035225
1
7,895
T
T
G
G
G
C
C
A
G
G
C
C
T
G
C
C
G
T
C
G
A
T
G
C
C
A
G
G
G
A
G
G
C
C
C
T
G
A
A
A
G
C
A
G
A
G
T
T
A
T
T
T
C
A
A
G
T
T
T
A
C
T
C
A
G
G
0.058708
0.029354
0.041096
0.052838
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0.013699
0.007828
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0.029354
0.04501
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0.023483
0.033268
0.041096
0.02544
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0.037182
0.027397
0.003914
0.007828
0.003914
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0.048924
0.013699
0.035225
0.037182
0.037182
0.023483
0.033268
0.041096
1
7,896
T
G
G
G
C
C
A
A
T
T
G
G
G
C
C
A
G
G
C
C
T
G
C
C
G
T
C
G
A
T
G
C
C
A
G
G
G
A
G
G
C
C
C
T
G
A
A
A
G
C
A
G
A
G
T
T
A
T
T
T
C
A
A
G
T
G
0.054795
0.029354
0.043053
0.048924
0.037182
0.013699
0.007828
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0.037182
0.029354
0.046967
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0.039139
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0.048924
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0.003914
0.007828
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0.046967
0.013699
0.035225
0.037182
0.037182
0.02544
0.033268
0.039139
1
7,897
T
G
G
G
C
C
A
A
T
T
G
G
G
C
C
A
G
G
C
C
T
G
C
C
G
T
C
G
A
T
G
C
C
A
G
G
G
A
G
G
C
C
C
T
G
A
A
A
G
C
A
G
A
G
T
T
A
T
T
T
C
A
A
G
T
A
0.054795
0.029354
0.043053
0.048924
0.037182
0.013699
0.007828
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0.046967
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0.048924
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0.027397
0.003914
0.007828
0.003914
0.021526
0.037182
0.046967
0.013699
0.035225
0.037182
0.037182
0.02544
0.033268
0.039139
1
7,898
G
T
T
G
C
C
A
G
G
C
T
C
T
C
C
T
C
T
T
G
C
T
C
C
A
G
C
T
G
G
G
C
C
A
A
T
T
G
G
G
C
C
A
G
G
C
C
T
G
C
C
G
T
C
G
A
T
G
C
C
A
G
G
G
A
G
0.060665
0.029354
0.037182
0.050881
0.035225
0.011742
0.007828
0.037182
0.035225
0.029354
0.046967
0.039139
0.029354
0.033268
0.035225
0.02544
0.050881
0.039139
0.02544
0.003914
0.007828
0.003914
0.023483
0.037182
0.043053
0.011742
0.031311
0.037182
0.041096
0.02544
0.037182
0.037182
1
7,899
G
G
G
T
C
C
A
G
G
G
A
A
T
C
C
A
A
T
G
T
T
G
C
C
A
G
G
C
T
C
T
C
C
T
C
T
T
G
C
T
C
C
A
G
C
T
G
G
G
C
C
A
A
T
T
G
G
G
C
C
A
G
G
C
C
T
0.058708
0.029354
0.037182
0.04501
0.037182
0.011742
0.007828
0.037182
0.035225
0.033268
0.043053
0.039139
0.029354
0.035225
0.033268
0.027397
0.052838
0.043053
0.02544
0.003914
0.007828
0.003914
0.023483
0.037182
0.041096
0.011742
0.031311
0.039139
0.039139
0.02544
0.037182
0.037182
1
7,900
T
T
C
T
T
A
C
A
G
T
G
G
G
G
C
C
T
T
T
G
G
G
T
C
C
A
G
G
G
A
A
T
C
C
A
A
T
G
T
T
G
C
C
A
G
G
C
T
C
T
C
C
T
C
T
T
G
C
T
C
C
A
G
C
T
T
0.058708
0.029354
0.039139
0.039139
0.041096
0.011742
0.005871
0.039139
0.037182
0.033268
0.04501
0.035225
0.029354
0.033268
0.031311
0.029354
0.056751
0.043053
0.027397
0.003914
0.005871
0.003914
0.023483
0.035225
0.039139
0.015656
0.029354
0.039139
0.041096
0.023483
0.039139
0.035225
1
7,901
T
T
C
T
T
A
C
A
G
T
G
G
G
G
C
C
T
T
T
G
G
G
T
C
C
A
G
G
G
A
A
T
C
C
A
A
T
G
T
T
G
C
C
A
G
G
C
T
C
T
C
C
T
C
T
T
G
C
T
C
C
A
G
C
T
A
0.058708
0.029354
0.039139
0.039139
0.041096
0.011742
0.005871
0.039139
0.037182
0.033268
0.04501
0.035225
0.029354
0.033268
0.031311
0.029354
0.056751
0.043053
0.027397
0.003914
0.005871
0.003914
0.023483
0.035225
0.039139
0.015656
0.029354
0.039139
0.041096
0.023483
0.039139
0.035225
1
7,902
A
A
G
A
C
C
A
G
C
A
T
G
A
C
C
T
T
T
A
T
C
A
C
C
G
T
T
T
T
T
G
C
C
A
G
G
A
T
C
A
C
C
C
T
A
G
A
G
T
A
A
A
A
A
T
G
A
A
A
A
A
C
A
A
A
T
0.117417
0.031311
0.037182
0.033268
0.056751
0.031311
0.003914
0.019569
0.039139
0.027397
0.029354
0.035225
0.052838
0.050881
0.037182
0.039139
0.037182
0.031311
0.021526
0.005871
0.001957
0
0.029354
0.013699
0.023483
0.017613
0.035225
0.007828
0.027397
0.023483
0.041096
0.041096
1
7,903
A
C
C
T
A
C
C
C
G
A
G
C
A
C
C
A
G
C
A
A
G
A
C
C
A
G
C
A
T
G
A
C
C
T
T
T
A
T
C
A
C
C
G
T
T
T
T
T
G
C
C
A
G
G
A
T
C
A
C
C
C
T
A
G
A
T
0.121331
0.031311
0.041096
0.035225
0.054795
0.031311
0.003914
0.019569
0.039139
0.031311
0.027397
0.029354
0.048924
0.050881
0.039139
0.039139
0.037182
0.033268
0.021526
0.005871
0.001957
0
0.02544
0.013699
0.02544
0.017613
0.037182
0.009785
0.023483
0.021526
0.041096
0.041096
1
7,904
C
A
C
C
T
A
C
C
C
G
A
G
C
A
C
C
A
G
C
A
A
G
A
C
C
A
G
C
A
T
G
A
C
C
T
T
T
A
T
C
A
C
C
G
T
T
T
T
T
G
C
C
A
G
G
A
T
C
A
C
C
C
T
A
G
T
0.123288
0.031311
0.041096
0.035225
0.054795
0.031311
0.003914
0.019569
0.039139
0.031311
0.027397
0.029354
0.048924
0.050881
0.039139
0.039139
0.037182
0.033268
0.019569
0.005871
0.001957
0
0.02544
0.013699
0.02544
0.017613
0.037182
0.009785
0.023483
0.021526
0.041096
0.041096
1
7,905
A
T
C
T
G
T
A
C
A
C
A
A
G
T
T
A
G
C
A
C
C
T
A
C
C
C
G
A
G
C
A
C
C
A
G
C
A
A
G
A
C
C
A
G
C
A
T
G
A
C
C
T
T
T
A
T
C
A
C
C
G
T
T
T
T
T
0.123288
0.031311
0.041096
0.041096
0.056751
0.031311
0.003914
0.019569
0.037182
0.029354
0.02544
0.031311
0.04501
0.050881
0.041096
0.039139
0.035225
0.031311
0.019569
0.005871
0.001957
0
0.023483
0.011742
0.027397
0.017613
0.035225
0.009785
0.021526
0.023483
0.04501
0.043053
1
7,906
G
A
T
C
T
G
T
A
C
A
C
A
A
G
T
T
A
G
C
A
C
C
T
A
C
C
C
G
A
G
C
A
C
C
A
G
C
A
A
G
A
C
C
A
G
C
A
T
G
A
C
C
T
T
T
A
T
C
A
C
C
G
T
T
T
T
0.123288
0.031311
0.041096
0.041096
0.056751
0.031311
0.003914
0.019569
0.037182
0.029354
0.02544
0.031311
0.04501
0.050881
0.041096
0.039139
0.035225
0.031311
0.019569
0.005871
0.001957
0
0.023483
0.011742
0.027397
0.017613
0.035225
0.009785
0.019569
0.023483
0.046967
0.043053
1
7,907
G
A
C
T
T
A
C
C
T
G
G
A
A
G
C
C
T
G
G
A
G
G
A
C
C
A
G
G
G
G
G
A
C
C
C
T
G
T
T
C
A
C
C
T
T
T
T
C
C
A
C
C
T
T
G
A
A
C
A
C
C
C
T
G
A
T
0.07045
0.031311
0.033268
0.041096
0.04501
0.043053
0.007828
0.029354
0.029354
0.033268
0.046967
0.046967
0.013699
0.031311
0.04501
0.041096
0.04501
0.04501
0.021526
0.001957
0.001957
0
0.019569
0.039139
0.033268
0.02544
0.027397
0.013699
0.037182
0.027397
0.027397
0.04501
1
7,908
A
T
T
G
T
A
T
A
T
G
T
T
T
G
A
G
T
T
G
A
C
T
T
A
C
C
T
G
G
A
A
G
C
C
T
G
G
A
G
G
A
C
C
A
G
G
G
G
G
A
C
C
C
T
G
T
T
C
A
C
C
T
T
T
T
T
0.064579
0.031311
0.031311
0.039139
0.043053
0.043053
0.011742
0.029354
0.027397
0.033268
0.04501
0.043053
0.015656
0.035225
0.046967
0.041096
0.043053
0.048924
0.023483
0.001957
0.001957
0
0.021526
0.039139
0.033268
0.02544
0.027397
0.013699
0.039139
0.029354
0.023483
0.046967
1
7,909
T
T
C
A
C
C
A
G
C
G
G
G
A
C
C
T
G
A
G
G
G
G
C
C
A
G
G
C
A
G
A
C
C
C
T
A
A
A
A
A
T
G
A
A
A
A
G
A
A
A
T
A
C
A
A
A
T
C
T
C
A
A
T
C
C
T
0.091977
0.033268
0.033268
0.066536
0.037182
0.031311
0.009785
0.037182
0.029354
0.02544
0.02544
0.04501
0.021526
0.037182
0.046967
0.02544
0.031311
0.035225
0.027397
0.003914
0.003914
0.001957
0.023483
0.029354
0.033268
0.007828
0.02544
0.017613
0.015656
0.048924
0.054795
0.043053
1
7,910
T
T
C
A
C
C
A
G
C
G
G
G
A
C
C
T
G
A
G
G
G
G
C
C
A
G
G
C
A
G
A
C
C
C
T
A
A
A
A
A
T
G
A
A
A
A
G
A
A
A
T
A
C
A
A
A
T
C
T
C
A
A
T
C
C
A
0.091977
0.033268
0.033268
0.066536
0.037182
0.031311
0.009785
0.037182
0.029354
0.02544
0.02544
0.04501
0.021526
0.037182
0.046967
0.02544
0.031311
0.035225
0.027397
0.003914
0.003914
0.001957
0.023483
0.029354
0.033268
0.007828
0.02544
0.017613
0.015656
0.048924
0.054795
0.043053
1
7,911
T
T
T
G
C
C
A
A
C
T
T
C
A
C
C
A
G
C
G
G
G
A
C
C
T
G
A
G
G
G
G
C
C
A
G
G
C
A
G
A
C
C
C
T
A
A
A
A
A
T
G
A
A
A
A
G
A
A
A
T
A
C
A
A
A
T
0.093933
0.035225
0.033268
0.066536
0.037182
0.031311
0.009785
0.035225
0.029354
0.02544
0.02544
0.041096
0.023483
0.041096
0.04501
0.02544
0.029354
0.035225
0.027397
0.003914
0.003914
0.001957
0.023483
0.029354
0.035225
0.007828
0.02544
0.017613
0.015656
0.04501
0.054795
0.04501
1
7,912
G
T
T
T
G
C
C
A
A
C
T
T
C
A
C
C
A
G
C
G
G
G
A
C
C
T
G
A
G
G
G
G
C
C
A
G
G
C
A
G
A
C
C
C
T
A
A
A
A
A
T
G
A
A
A
A
G
A
A
A
T
A
C
A
A
T
0.093933
0.035225
0.033268
0.066536
0.037182
0.031311
0.009785
0.035225
0.029354
0.02544
0.02544
0.041096
0.023483
0.041096
0.04501
0.02544
0.029354
0.035225
0.027397
0.003914
0.003914
0.001957
0.023483
0.029354
0.035225
0.007828
0.023483
0.017613
0.015656
0.04501
0.054795
0.046967
1
7,913
A
C
T
C
A
C
C
C
T
T
T
C
T
C
C
T
G
G
T
T
T
G
C
C
A
A
C
T
T
C
A
C
C
A
G
C
G
G
G
A
C
C
T
G
A
G
G
G
G
C
C
A
G
G
C
A
G
A
C
C
C
T
A
A
A
T
0.097847
0.035225
0.035225
0.066536
0.037182
0.031311
0.009785
0.037182
0.029354
0.023483
0.023483
0.041096
0.023483
0.043053
0.041096
0.027397
0.027397
0.033268
0.027397
0.003914
0.003914
0.001957
0.021526
0.029354
0.037182
0.005871
0.023483
0.013699
0.015656
0.046967
0.058708
0.046967
1
7,914
A
C
T
T
G
T
T
T
T
A
C
T
C
A
C
C
C
T
T
T
C
T
C
C
T
G
G
T
T
T
G
C
C
A
A
C
T
T
C
A
C
C
A
G
C
G
G
G
A
C
C
T
G
A
G
G
G
G
C
C
A
G
G
C
A
T
0.09589
0.035225
0.035225
0.068493
0.035225
0.031311
0.009785
0.037182
0.031311
0.019569
0.023483
0.043053
0.027397
0.04501
0.043053
0.027397
0.02544
0.033268
0.027397
0.003914
0.003914
0.001957
0.023483
0.027397
0.037182
0.005871
0.023483
0.013699
0.015656
0.04501
0.056751
0.046967
1
7,915
C
A
C
T
T
A
C
T
C
T
T
G
G
A
C
C
A
G
C
A
G
G
A
C
C
A
G
G
G
A
G
A
C
C
A
A
A
C
T
C
A
C
C
A
T
G
G
A
G
A
C
C
C
T
A
G
A
C
A
A
A
A
C
A
T
T
0.099804
0.031311
0.043053
0.064579
0.04501
0.017613
0
0.04501
0.056751
0.015656
0.015656
0.048924
0.029354
0.046967
0.039139
0.027397
0.027397
0.029354
0.009785
0
0
0
0.033268
0.029354
0.04501
0.017613
0.023483
0.007828
0.021526
0.031311
0.054795
0.043053
1
7,916
A
T
G
A
A
G
T
A
A
C
A
C
T
T
A
C
T
C
T
T
G
G
A
C
C
A
G
C
A
G
G
A
C
C
A
G
G
G
A
G
A
C
C
A
A
A
C
T
C
A
C
C
A
T
G
G
A
G
A
C
C
C
T
A
G
G
0.09589
0.029354
0.043053
0.064579
0.043053
0.017613
0
0.04501
0.056751
0.015656
0.015656
0.062622
0.029354
0.046967
0.037182
0.027397
0.027397
0.029354
0.007828
0
0
0
0.033268
0.029354
0.043053
0.017613
0.023483
0.007828
0.019569
0.031311
0.056751
0.043053
1
7,917
T
G
A
A
A
G
T
T
A
A
T
G
A
A
G
T
A
A
C
A
C
T
T
A
C
T
C
T
T
G
G
A
C
C
A
G
C
A
G
G
A
C
C
A
G
G
G
A
G
A
C
C
A
A
A
C
T
C
A
C
C
A
T
G
G
G
0.088063
0.029354
0.043053
0.062622
0.043053
0.017613
0
0.048924
0.056751
0.015656
0.015656
0.062622
0.027397
0.046967
0.035225
0.029354
0.029354
0.029354
0.007828
0
0
0
0.035225
0.029354
0.043053
0.019569
0.023483
0.007828
0.019569
0.031311
0.056751
0.04501
1
7,918
T
G
A
A
A
G
T
T
A
A
T
G
A
A
G
T
A
A
C
A
C
T
T
A
C
T
C
T
T
G
G
A
C
C
A
G
C
A
G
G
A
C
C
A
G
G
G
A
G
A
C
C
A
A
A
C
T
C
A
C
C
A
T
G
G
A
0.088063
0.029354
0.043053
0.062622
0.043053
0.017613
0
0.048924
0.056751
0.015656
0.015656
0.062622
0.027397
0.046967
0.035225
0.029354
0.029354
0.029354
0.007828
0
0
0
0.035225
0.029354
0.043053
0.019569
0.023483
0.007828
0.019569
0.031311
0.056751
0.04501
1
7,919
A
G
G
A
C
C
G
G
C
A
G
C
A
C
C
A
C
T
C
T
C
A
C
C
T
G
G
G
G
G
A
C
C
G
C
G
T
T
C
C
C
C
C
T
G
A
A
A
A
A
A
G
T
G
A
T
T
A
G
A
A
G
A
A
G
T
0.072407
0.027397
0.035225
0.062622
0.029354
0.02544
0.005871
0.041096
0.050881
0.021526
0.029354
0.037182
0.027397
0.027397
0.027397
0.027397
0.043053
0.037182
0.027397
0.011742
0.009785
0.003914
0.033268
0.031311
0.052838
0.023483
0.021526
0.015656
0.037182
0.023483
0.043053
0.037182
1
7,920
A
G
G
A
C
C
T
C
G
G
C
T
T
C
C
A
A
T
A
G
G
A
C
C
A
G
T
A
G
G
A
C
C
G
G
C
A
G
C
A
C
C
A
C
T
C
T
C
A
C
C
T
G
G
G
G
G
A
C
C
G
C
G
T
T
T
0.080235
0.035225
0.033268
0.058708
0.037182
0.02544
0.003914
0.039139
0.046967
0.021526
0.029354
0.035225
0.027397
0.027397
0.035225
0.027397
0.041096
0.035225
0.027397
0.011742
0.007828
0.003914
0.033268
0.029354
0.048924
0.023483
0.021526
0.015656
0.035225
0.021526
0.043053
0.037182
1
7,921
A
A
C
A
T
A
A
G
A
T
T
T
T
A
C
C
T
T
G
T
T
T
C
C
A
T
C
A
G
G
C
C
C
T
G
G
G
G
G
T
C
C
A
G
A
A
G
G
A
C
C
T
C
G
G
C
T
T
C
C
A
A
T
A
G
T
0.088063
0.037182
0.029354
0.064579
0.037182
0.02544
0.001957
0.037182
0.043053
0.017613
0.029354
0.037182
0.027397
0.02544
0.037182
0.02544
0.04501
0.037182
0.035225
0.011742
0.005871
0.003914
0.027397
0.02544
0.052838
0.017613
0.021526
0.015656
0.037182
0.021526
0.041096
0.037182
1
7,922
A
A
A
C
A
T
A
A
G
A
T
T
T
T
A
C
C
T
T
G
T
T
T
C
C
A
T
C
A
G
G
C
C
C
T
G
G
G
G
G
T
C
C
A
G
A
A
G
G
A
C
C
T
C
G
G
C
T
T
C
C
A
A
T
A
A
0.088063
0.037182
0.029354
0.064579
0.037182
0.02544
0.001957
0.037182
0.043053
0.017613
0.029354
0.035225
0.027397
0.027397
0.037182
0.02544
0.04501
0.037182
0.035225
0.011742
0.005871
0.003914
0.027397
0.02544
0.052838
0.017613
0.021526
0.015656
0.037182
0.021526
0.041096
0.037182
1
7,923
G
G
A
G
T
C
C
A
C
T
A
G
G
A
C
C
A
G
A
T
G
G
A
C
C
A
G
C
A
G
T
G
C
C
C
A
C
A
G
C
A
C
C
A
A
C
C
A
C
A
C
C
A
G
G
T
T
C
A
C
C
C
T
T
G
T
0.048924
0.023483
0.037182
0.041096
0.039139
0.035225
0.003914
0.027397
0.058708
0.037182
0.043053
0.029354
0.021526
0.033268
0.037182
0.046967
0.04501
0.043053
0.027397
0
0.001957
0.001957
0.04501
0.039139
0.048924
0.017613
0.043053
0.023483
0.027397
0.017613
0.017613
0.037182
1
7,924
G
G
A
G
T
C
C
A
C
T
A
G
G
A
C
C
A
G
A
T
G
G
A
C
C
A
G
C
A
G
T
G
C
C
C
A
C
A
G
C
A
C
C
A
A
C
C
A
C
A
C
C
A
G
G
T
T
C
A
C
C
C
T
T
G
A
0.048924
0.023483
0.037182
0.041096
0.039139
0.035225
0.003914
0.027397
0.058708
0.037182
0.043053
0.029354
0.021526
0.033268
0.037182
0.046967
0.04501
0.043053
0.027397
0
0.001957
0.001957
0.04501
0.039139
0.048924
0.017613
0.043053
0.023483
0.027397
0.017613
0.017613
0.037182
1
7,925
C
T
C
T
C
C
T
G
G
G
A
G
T
C
C
A
C
T
A
G
G
A
C
C
A
G
A
T
G
G
A
C
C
A
G
C
A
G
T
G
C
C
C
A
C
A
G
C
A
C
C
A
A
C
C
A
C
A
C
C
A
G
G
T
T
T
0.050881
0.023483
0.039139
0.043053
0.039139
0.035225
0.003914
0.027397
0.058708
0.035225
0.04501
0.029354
0.019569
0.033268
0.039139
0.046967
0.043053
0.043053
0.027397
0
0
0
0.04501
0.039139
0.048924
0.017613
0.041096
0.023483
0.029354
0.017613
0.017613
0.037182
1
7,926
T
T
C
T
C
C
C
T
T
G
C
C
T
C
C
A
G
G
T
A
T
G
C
C
A
G
C
A
G
C
A
C
C
C
C
T
C
T
C
T
C
C
T
G
G
G
A
G
T
C
C
A
C
T
A
G
G
A
C
C
A
G
A
T
G
A
0.054795
0.027397
0.037182
0.046967
0.04501
0.035225
0.003914
0.021526
0.056751
0.035225
0.043053
0.029354
0.019569
0.037182
0.043053
0.04501
0.041096
0.04501
0.023483
0
0
0
0.04501
0.035225
0.050881
0.015656
0.039139
0.023483
0.029354
0.017613
0.017613
0.035225
1
7,927
T
A
T
G
T
A
A
T
A
G
G
G
G
T
C
A
A
C
A
C
G
T
A
C
C
T
T
T
T
C
T
C
C
C
T
T
G
C
C
T
C
C
A
G
G
T
A
T
G
C
C
A
G
C
A
G
C
A
C
C
C
C
T
C
T
T
0.058708
0.02544
0.037182
0.050881
0.043053
0.035225
0.003914
0.023483
0.048924
0.033268
0.04501
0.031311
0.017613
0.037182
0.043053
0.04501
0.037182
0.046967
0.023483
0
0
0
0.043053
0.033268
0.050881
0.013699
0.037182
0.027397
0.029354
0.021526
0.019569
0.037182
1
7,928
A
T
A
T
G
T
A
A
T
A
G
G
G
G
T
C
A
A
C
A
C
G
T
A
C
C
T
T
T
T
C
T
C
C
C
T
T
G
C
C
T
C
C
A
G
G
T
A
T
G
C
C
A
G
C
A
G
C
A
C
C
C
C
T
C
T
0.058708
0.02544
0.037182
0.050881
0.043053
0.035225
0.003914
0.023483
0.048924
0.033268
0.04501
0.029354
0.017613
0.037182
0.043053
0.046967
0.037182
0.046967
0.023483
0
0
0
0.043053
0.033268
0.050881
0.013699
0.037182
0.027397
0.029354
0.021526
0.019569
0.037182
1
7,929
G
T
T
A
C
C
A
A
T
T
T
C
A
C
C
T
C
T
G
A
G
A
C
C
A
G
G
T
T
C
A
C
C
C
T
G
A
A
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G
T
A
T
A
A
A
G
C
A
A
G
A
G
C
A
A
C
T
T
T
T
T
G
T
T
A
0.135029
0.031311
0.041096
0.088063
0.035225
0.023483
0.005871
0.023483
0.050881
0.011742
0.02544
0.043053
0.02544
0.035225
0.037182
0.017613
0.023483
0.02544
0.007828
0.001957
0.015656
0
0.017613
0.029354
0.062622
0.011742
0.013699
0.005871
0.023483
0.027397
0.064579
0.039139
1
7,930
T
C
T
G
C
C
A
G
G
G
T
T
A
C
C
A
A
T
T
T
C
A
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C
T
C
T
G
A
G
A
C
C
A
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G
T
T
C
A
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T
G
A
A
A
G
T
A
T
A
A
A
G
C
A
A
G
A
G
C
A
A
T
0.138943
0.031311
0.039139
0.091977
0.035225
0.023483
0.005871
0.023483
0.050881
0.009785
0.02544
0.046967
0.027397
0.033268
0.037182
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0.021526
0.02544
0.007828
0.001957
0.015656
0
0.017613
0.029354
0.060665
0.011742
0.011742
0.005871
0.023483
0.027397
0.064579
0.037182
1
7,931
T
C
T
G
C
C
A
G
G
G
T
T
A
C
C
A
A
T
T
T
C
A
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C
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G
A
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A
C
C
A
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G
T
T
C
A
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T
G
A
A
A
G
T
A
T
A
A
A
G
C
A
A
G
A
G
C
A
A
A
0.138943
0.031311
0.039139
0.091977
0.035225
0.023483
0.005871
0.023483
0.050881
0.009785
0.02544
0.046967
0.027397
0.033268
0.037182
0.017613
0.021526
0.02544
0.007828
0.001957
0.015656
0
0.017613
0.029354
0.060665
0.011742
0.011742
0.005871
0.023483
0.027397
0.064579
0.037182
1
7,932
A
G
C
A
C
C
A
T
C
T
C
T
G
C
C
A
G
G
G
T
T
A
C
C
A
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T
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C
A
C
C
T
C
T
G
A
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A
C
C
A
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G
T
T
C
A
C
C
C
T
G
A
A
A
G
T
A
T
A
A
A
G
G
0.142857
0.031311
0.039139
0.09589
0.033268
0.023483
0.005871
0.021526
0.048924
0.009785
0.02544
0.046967
0.027397
0.033268
0.037182
0.015656
0.023483
0.02544
0.007828
0.001957
0.015656
0
0.017613
0.02544
0.062622
0.011742
0.011742
0.005871
0.023483
0.02544
0.064579
0.039139
1
7,933
G
A
G
C
A
C
C
A
T
C
T
C
T
G
C
C
A
G
G
G
T
T
A
C
C
A
A
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T
C
A
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T
C
T
G
A
G
A
C
C
A
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G
T
T
C
A
C
C
C
T
G
A
A
A
G
T
A
T
A
A
A
A
0.142857
0.031311
0.039139
0.09589
0.033268
0.023483
0.005871
0.021526
0.048924
0.009785
0.02544
0.046967
0.027397
0.033268
0.037182
0.015656
0.023483
0.02544
0.007828
0.001957
0.015656
0
0.017613
0.02544
0.064579
0.011742
0.011742
0.005871
0.023483
0.023483
0.064579
0.039139
1
7,934
A
A
C
A
T
A
C
A
A
A
C
A
A
A
A
T
T
C
T
A
C
T
C
A
C
A
C
G
A
G
C
A
C
C
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T
C
T
C
T
G
C
C
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G
G
G
T
T
A
C
C
A
A
T
T
T
C
A
C
C
T
C
T
G
T
0.135029
0.029354
0.039139
0.09002
0.031311
0.02544
0.003914
0.02544
0.046967
0.009785
0.027397
0.048924
0.027397
0.035225
0.037182
0.017613
0.023483
0.027397
0.009785
0
0.015656
0
0.021526
0.02544
0.062622
0.013699
0.011742
0.005871
0.023483
0.02544
0.060665
0.043053
1
7,935
C
A
G
G
A
C
C
A
G
G
G
G
C
A
C
C
T
A
C
A
G
C
A
C
C
A
G
G
A
G
C
A
C
C
C
T
A
G
T
A
C
C
A
A
A
A
A
G
G
A
A
A
C
A
T
G
T
C
T
T
A
T
T
A
A
T
0.078278
0.023483
0.043053
0.048924
0.037182
0.033268
0.001957
0.031311
0.037182
0.041096
0.041096
0.04501
0.021526
0.02544
0.031311
0.035225
0.04501
0.035225
0.027397
0.007828
0
0.001957
0.041096
0.021526
0.037182
0.017613
0.033268
0.021526
0.029354
0.027397
0.046967
0.031311
1
7,936
G
G
T
C
A
C
C
T
G
T
G
G
C
T
C
C
A
G
C
A
G
G
A
C
C
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G
G
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C
A
C
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T
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C
A
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C
A
C
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A
G
G
A
G
C
A
C
C
C
T
A
G
T
A
C
C
A
A
A
A
A
T
0.074364
0.023483
0.043053
0.046967
0.037182
0.031311
0.001957
0.033268
0.037182
0.041096
0.043053
0.048924
0.023483
0.02544
0.029354
0.035225
0.043053
0.033268
0.027397
0.007828
0
0.001957
0.046967
0.021526
0.035225
0.015656
0.033268
0.021526
0.029354
0.029354
0.048924
0.029354
1
7,937
T
G
C
T
T
A
C
C
C
G
G
T
C
A
C
C
T
G
T
G
G
C
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C
C
A
G
C
A
G
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A
C
C
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G
G
G
C
A
C
C
T
A
C
A
G
C
A
C
C
A
G
G
A
G
C
A
C
C
C
T
A
G
T
0.076321
0.02544
0.043053
0.046967
0.039139
0.031311
0.001957
0.033268
0.037182
0.041096
0.041096
0.046967
0.023483
0.027397
0.029354
0.035225
0.041096
0.033268
0.027397
0.007828
0
0.001957
0.046967
0.021526
0.035225
0.015656
0.033268
0.021526
0.029354
0.029354
0.048924
0.027397
1
7,938
A
G
G
A
C
C
A
G
C
A
G
G
A
C
C
A
G
C
A
G
C
C
C
C
A
G
C
T
T
C
G
C
C
C
T
A
T
A
A
T
G
G
G
A
C
C
A
A
A
G
A
T
G
A
A
T
C
T
G
T
T
A
A
T
G
G
0.046967
0.029354
0.029354
0.043053
0.046967
0.035225
0.005871
0.033268
0.039139
0.023483
0.04501
0.035225
0.031311
0.039139
0.027397
0.037182
0.050881
0.041096
0.037182
0.003914
0.005871
0.003914
0.02544
0.035225
0.029354
0.029354
0.023483
0.015656
0.039139
0.02544
0.04501
0.041096
1
7,939
C
A
G
G
A
C
C
A
G
C
A
G
G
A
C
C
A
G
C
A
G
C
C
C
C
A
G
C
T
T
C
G
C
C
C
T
A
T
A
A
T
G
G
G
A
C
C
A
A
A
G
A
T
G
A
A
T
C
T
G
T
T
A
A
T
T
0.046967
0.029354
0.029354
0.043053
0.046967
0.035225
0.005871
0.033268
0.039139
0.023483
0.04501
0.035225
0.031311
0.039139
0.027397
0.037182
0.050881
0.043053
0.037182
0.003914
0.005871
0.003914
0.02544
0.035225
0.029354
0.029354
0.023483
0.015656
0.039139
0.02544
0.043053
0.041096
1
7,940
G
C
T
T
C
C
C
C
G
A
G
G
A
C
C
A
G
C
A
G
G
A
C
C
A
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C
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G
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A
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C
A
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C
C
C
C
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G
C
T
T
C
G
C
C
C
T
A
T
A
A
T
G
G
G
A
C
C
A
G
0.043053
0.029354
0.029354
0.041096
0.04501
0.035225
0.005871
0.037182
0.041096
0.023483
0.039139
0.035225
0.031311
0.037182
0.027397
0.039139
0.048924
0.043053
0.043053
0.005871
0.007828
0.003914
0.027397
0.035225
0.029354
0.029354
0.023483
0.015656
0.035225
0.027397
0.043053
0.041096
1
7,941
G
C
T
T
C
C
C
C
G
A
G
G
A
C
C
A
G
C
A
G
G
A
C
C
A
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C
A
G
G
A
C
C
A
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C
A
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C
C
C
C
A
G
C
T
T
C
G
C
C
C
T
A
T
A
A
T
G
G
G
A
C
C
A
A
0.043053
0.029354
0.029354
0.041096
0.04501
0.035225
0.005871
0.037182
0.041096
0.023483
0.039139
0.035225
0.031311
0.037182
0.027397
0.039139
0.048924
0.043053
0.043053
0.005871
0.007828
0.003914
0.027397
0.035225
0.029354
0.029354
0.023483
0.015656
0.035225
0.027397
0.043053
0.041096
1
7,942
G
G
C
T
T
C
C
C
C
G
A
G
G
A
C
C
A
G
C
A
G
G
A
C
C
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C
A
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G
A
C
C
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C
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C
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G
C
T
T
C
G
C
C
C
T
A
T
A
A
T
G
G
G
A
C
C
T
0.043053
0.029354
0.029354
0.041096
0.04501
0.035225
0.005871
0.037182
0.041096
0.023483
0.039139
0.035225
0.031311
0.037182
0.027397
0.039139
0.048924
0.043053
0.043053
0.005871
0.007828
0.003914
0.027397
0.035225
0.029354
0.029354
0.023483
0.015656
0.037182
0.02544
0.043053
0.041096
1
7,943
C
A
A
A
T
C
C
A
T
T
G
G
G
G
C
C
A
G
C
A
G
G
A
C
C
G
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C
C
T
C
A
C
C
A
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G
T
T
C
A
C
C
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T
A
G
G
T
G
G
G
A
G
A
A
G
G
G
A
T
T
T
A
A
T
0.037182
0.037182
0.027397
0.031311
0.04501
0.046967
0.007828
0.019569
0.033268
0.043053
0.050881
0.019569
0.023483
0.027397
0.031311
0.037182
0.062622
0.054795
0.048924
0.009785
0.007828
0.001957
0.021526
0.035225
0.029354
0.029354
0.023483
0.02544
0.043053
0.017613
0.035225
0.035225
1
7,944
A
G
G
A
C
C
A
G
C
A
A
A
T
C
C
A
T
T
G
G
G
G
C
C
A
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C
A
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A
C
C
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C
T
C
A
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A
C
G
T
T
C
A
C
C
C
T
A
G
G
T
G
G
G
A
G
A
A
G
T
0.037182
0.037182
0.027397
0.035225
0.043053
0.046967
0.007828
0.021526
0.031311
0.043053
0.050881
0.019569
0.023483
0.027397
0.031311
0.037182
0.062622
0.052838
0.048924
0.009785
0.007828
0.001957
0.021526
0.035225
0.033268
0.02544
0.023483
0.02544
0.041096
0.017613
0.035225
0.037182
1
7,945
T
T
C
T
C
C
T
T
T
A
G
C
A
C
C
A
G
G
T
T
G
A
C
C
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C
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A
A
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A
A
C
A
G
T
T
A
C
A
G
C
T
C
T
G
G
T
A
T
T
0.043053
0.037182
0.029354
0.04501
0.04501
0.04501
0.011742
0.021526
0.027397
0.037182
0.043053
0.037182
0.029354
0.02544
0.035225
0.04501
0.052838
0.050881
0.035225
0.011742
0.003914
0
0.02544
0.023483
0.033268
0.019569
0.029354
0.019569
0.041096
0.021526
0.041096
0.033268
1
7,946
A
G
G
C
C
C
T
T
T
G
G
C
T
C
C
T
C
T
T
T
C
T
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C
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T
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A
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C
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C
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C
A
G
C
A
C
C
C
T
G
T
T
G
G
A
A
A
T
A
A
A
A
0.050881
0.037182
0.029354
0.04501
0.04501
0.041096
0.011742
0.023483
0.02544
0.037182
0.041096
0.041096
0.029354
0.02544
0.037182
0.04501
0.048924
0.048924
0.033268
0.011742
0.003914
0
0.02544
0.023483
0.033268
0.019569
0.029354
0.019569
0.041096
0.021526
0.041096
0.033268
1
7,947
T
T
C
A
C
C
C
T
T
A
G
G
C
C
C
T
T
T
G
G
C
T
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A
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C
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T
T
G
A
C
C
A
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C
A
G
C
A
C
C
C
T
G
T
T
T
0.046967
0.037182
0.029354
0.046967
0.043053
0.041096
0.011742
0.023483
0.02544
0.037182
0.041096
0.04501
0.029354
0.027397
0.035225
0.04501
0.048924
0.048924
0.033268
0.011742
0.003914
0
0.02544
0.023483
0.035225
0.017613
0.029354
0.019569
0.041096
0.019569
0.041096
0.035225
1
7,948
T
T
C
A
C
C
C
T
T
A
G
G
C
C
C
T
T
T
G
G
C
T
C
C
T
C
T
T
T
C
T
C
C
T
T
T
A
G
C
A
C
C
A
G
G
T
T
G
A
C
C
A
G
C
A
G
C
A
C
C
C
T
G
T
T
G
0.046967
0.037182
0.029354
0.046967
0.043053
0.041096
0.011742
0.023483
0.02544
0.037182
0.041096
0.04501
0.029354
0.027397
0.035225
0.04501
0.048924
0.048924
0.033268
0.011742
0.003914
0
0.02544
0.023483
0.035225
0.017613
0.029354
0.019569
0.041096
0.019569
0.041096
0.035225
1
7,949
A
G
C
T
C
C
A
A
C
G
G
G
G
C
C
T
G
T
G
G
G
A
C
C
A
A
C
A
A
C
A
C
C
G
T
T
T
T
C
A
C
C
C
T
T
A
G
G
C
C
C
T
T
T
G
G
C
T
C
C
T
C
T
T
T
T
0.052838
0.037182
0.031311
0.048924
0.037182
0.041096
0.011742
0.021526
0.027397
0.037182
0.043053
0.046967
0.029354
0.023483
0.033268
0.041096
0.050881
0.048924
0.035225
0.011742
0.003914
0
0.023483
0.023483
0.035225
0.015656
0.029354
0.019569
0.041096
0.017613
0.048924
0.031311
1
7,950
C
A
G
C
T
C
C
A
A
C
G
G
G
G
C
C
T
G
T
G
G
G
A
C
C
A
A
C
A
A
C
A
C
C
G
T
T
T
T
C
A
C
C
C
T
T
A
G
G
C
C
C
T
T
T
G
G
C
T
C
C
T
C
T
T
A
0.052838
0.037182
0.031311
0.048924
0.037182
0.041096
0.011742
0.021526
0.027397
0.037182
0.041096
0.046967
0.029354
0.023483
0.033268
0.041096
0.050881
0.050881
0.035225
0.011742
0.003914
0
0.023483
0.023483
0.035225
0.015656
0.029354
0.019569
0.041096
0.017613
0.048924
0.031311
1
7,951
G
T
G
A
A
T
T
C
A
A
C
T
T
A
C
A
G
C
T
G
G
G
C
C
A
G
C
A
G
C
T
C
C
A
A
C
G
G
G
G
C
C
T
G
T
G
G
G
A
C
C
A
A
C
A
A
C
A
C
C
G
T
T
T
T
T
0.04501
0.037182
0.033268
0.048924
0.039139
0.043053
0.011742
0.021526
0.031311
0.037182
0.039139
0.048924
0.023483
0.023483
0.033268
0.041096
0.054795
0.050881
0.035225
0.011742
0.003914
0
0.019569
0.023483
0.041096
0.017613
0.029354
0.019569
0.037182
0.019569
0.04501
0.033268
1
7,952
A
C
T
T
C
C
A
G
C
A
G
G
A
C
C
G
G
G
G
G
G
A
C
C
A
T
T
T
G
G
A
C
C
C
T
A
A
A
T
G
C
A
A
A
C
A
A
A
A
A
G
A
T
G
G
A
G
T
C
A
A
A
T
C
A
T
0.097847
0.033268
0.046967
0.064579
0.033268
0.019569
0.003914
0.039139
0.043053
0.019569
0.019569
0.043053
0.029354
0.039139
0.046967
0.023483
0.02544
0.027397
0.023483
0.011742
0.005871
0.005871
0.017613
0.029354
0.056751
0.019569
0.019569
0.005871
0.033268
0.019569
0.041096
0.054795
1
7,953
A
C
T
T
C
C
A
G
C
A
G
G
A
C
C
G
G
G
G
G
G
A
C
C
A
T
T
T
G
G
A
C
C
C
T
A
A
A
T
G
C
A
A
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A
A
A
A
A
G
A
T
G
G
A
G
T
C
A
A
A
T
C
A
G
0.097847
0.033268
0.046967
0.064579
0.033268
0.019569
0.003914
0.039139
0.043053
0.019569
0.019569
0.043053
0.029354
0.039139
0.046967
0.023483
0.02544
0.027397
0.023483
0.011742
0.005871
0.005871
0.017613
0.029354
0.056751
0.019569
0.019569
0.005871
0.033268
0.019569
0.041096
0.054795
1
7,954
A
T
C
A
C
C
A
C
G
A
C
T
T
C
C
A
G
C
A
G
G
A
C
C
G
G
G
G
G
G
A
C
C
A
T
T
T
G
G
A
C
C
C
T
A
A
A
T
G
C
A
A
A
C
A
A
A
A
A
G
A
T
G
G
A
A
0.097847
0.035225
0.04501
0.066536
0.033268
0.021526
0.003914
0.039139
0.039139
0.019569
0.021526
0.04501
0.027397
0.037182
0.046967
0.023483
0.02544
0.02544
0.023483
0.011742
0.005871
0.005871
0.017613
0.031311
0.052838
0.019569
0.019569
0.005871
0.031311
0.021526
0.04501
0.054795
1
7,955
G
G
G
G
C
C
T
C
C
A
T
C
A
C
C
A
C
G
A
C
T
T
C
C
A
G
C
A
G
G
A
C
C
G
G
G
G
G
G
A
C
C
A
T
T
T
G
G
A
C
C
C
T
A
A
A
T
G
C
A
A
A
C
A
A
A
0.093933
0.033268
0.046967
0.064579
0.033268
0.02544
0.001957
0.039139
0.039139
0.019569
0.023483
0.043053
0.027397
0.037182
0.048924
0.02544
0.02544
0.029354
0.02544
0.009785
0.005871
0.005871
0.017613
0.031311
0.052838
0.019569
0.019569
0.005871
0.029354
0.021526
0.043053
0.054795
1
7,956
A
C
T
C
A
C
A
G
G
G
G
G
G
C
C
T
C
C
A
T
C
A
C
C
A
C
G
A
C
T
T
C
C
A
G
C
A
G
G
A
C
C
G
G
G
G
G
G
A
C
C
A
T
T
T
G
G
A
C
C
C
T
A
A
A
G
0.093933
0.031311
0.04501
0.062622
0.033268
0.02544
0.001957
0.039139
0.039139
0.019569
0.02544
0.043053
0.02544
0.037182
0.048924
0.02544
0.02544
0.029354
0.027397
0.009785
0.005871
0.005871
0.021526
0.031311
0.050881
0.019569
0.021526
0.011742
0.027397
0.021526
0.039139
0.054795
1
7,957
A
T
T
G
T
A
A
A
T
A
C
T
C
A
C
A
G
G
G
G
G
G
C
C
T
C
C
A
T
C
A
C
C
A
C
G
A
C
T
T
C
C
A
G
C
A
G
G
A
C
C
G
G
G
G
G
G
A
C
C
A
T
T
T
G
T
0.093933
0.033268
0.04501
0.064579
0.029354
0.02544
0.001957
0.041096
0.039139
0.019569
0.02544
0.043053
0.02544
0.035225
0.048924
0.023483
0.027397
0.029354
0.027397
0.009785
0.005871
0.005871
0.021526
0.031311
0.050881
0.019569
0.017613
0.011742
0.027397
0.021526
0.043053
0.054795
1
7,958
C
G
A
G
A
G
T
C
C
A
T
T
G
T
A
A
A
T
A
C
T
C
A
C
A
G
G
G
G
G
G
C
C
T
C
C
A
T
C
A
C
C
A
C
G
A
C
T
T
C
C
A
G
C
A
G
G
A
C
C
G
G
G
G
G
G
0.093933
0.033268
0.04501
0.064579
0.031311
0.02544
0.001957
0.041096
0.039139
0.017613
0.02544
0.043053
0.02544
0.035225
0.048924
0.021526
0.02544
0.029354
0.027397
0.011742
0.007828
0.005871
0.021526
0.031311
0.050881
0.021526
0.015656
0.011742
0.027397
0.021526
0.043053
0.054795
1
7,959
G
C
G
A
G
A
G
T
C
C
A
T
T
G
T
A
A
A
T
A
C
T
C
A
C
A
G
G
G
G
G
G
C
C
T
C
C
A
T
C
A
C
C
A
C
G
A
C
T
T
C
C
A
G
C
A
G
G
A
C
C
G
G
G
G
T
0.093933
0.033268
0.04501
0.064579
0.029354
0.02544
0.001957
0.041096
0.039139
0.017613
0.02544
0.043053
0.02544
0.035225
0.048924
0.021526
0.02544
0.029354
0.027397
0.011742
0.007828
0.005871
0.021526
0.031311
0.050881
0.021526
0.015656
0.011742
0.029354
0.021526
0.043053
0.054795
1
7,960
G
C
G
A
G
A
G
T
C
C
A
T
T
G
T
A
A
A
T
A
C
T
C
A
C
A
G
G
G
G
G
G
C
C
T
C
C
A
T
C
A
C
C
A
C
G
A
C
T
T
C
C
A
G
C
A
G
G
A
C
C
G
G
G
G
A
0.093933
0.033268
0.04501
0.064579
0.029354
0.02544
0.001957
0.041096
0.039139
0.017613
0.02544
0.043053
0.02544
0.035225
0.048924
0.021526
0.02544
0.029354
0.027397
0.011742
0.007828
0.005871
0.021526
0.031311
0.050881
0.021526
0.015656
0.011742
0.029354
0.021526
0.043053
0.054795
1
7,961
G
G
G
G
A
C
C
A
G
T
C
C
G
T
C
C
A
G
C
A
G
C
A
C
C
A
G
G
G
A
A
A
C
C
A
G
T
C
A
T
A
C
C
C
T
A
A
G
A
G
C
C
A
A
G
C
A
C
A
T
T
A
G
A
A
G
0.056751
0.029354
0.046967
0.046967
0.031311
0.035225
0.007828
0.033268
0.035225
0.027397
0.04501
0.04501
0.019569
0.041096
0.027397
0.02544
0.046967
0.048924
0.023483
0.001957
0.001957
0.003914
0.023483
0.023483
0.048924
0.02544
0.019569
0.023483
0.037182
0.029354
0.046967
0.041096
1
7,962
A
C
A
G
T
G
A
T
T
T
A
C
T
T
A
C
A
G
A
G
G
G
T
C
C
T
G
G
G
G
G
A
C
C
A
G
T
C
C
G
T
C
C
A
G
C
A
G
C
A
C
C
A
G
G
G
A
A
A
C
C
A
G
T
C
G
0.054795
0.02544
0.048924
0.04501
0.031311
0.035225
0.005871
0.035225
0.037182
0.027397
0.046967
0.041096
0.017613
0.041096
0.023483
0.02544
0.050881
0.046967
0.031311
0.001957
0.001957
0.001957
0.023483
0.023483
0.050881
0.027397
0.019569
0.02544
0.037182
0.029354
0.043053
0.043053
1
7,963
G
A
C
A
C
G
T
T
T
A
C
A
G
T
G
A
T
T
T
A
C
T
T
A
C
A
G
A
G
G
G
T
C
C
T
G
G
G
G
G
A
C
C
A
G
T
C
C
G
T
C
C
A
G
C
A
G
C
A
C
C
A
G
G
G
T
0.066536
0.02544
0.048924
0.043053
0.031311
0.035225
0.005871
0.035225
0.037182
0.027397
0.046967
0.041096
0.017613
0.039139
0.021526
0.02544
0.050881
0.046967
0.029354
0.001957
0.001957
0.001957
0.023483
0.023483
0.052838
0.027397
0.013699
0.023483
0.037182
0.029354
0.043053
0.04501
1
7,964
C
A
G
G
A
C
C
A
G
G
G
G
G
A
C
C
A
G
G
A
G
G
G
C
C
A
G
A
A
A
T
A
C
C
C
T
A
T
G
A
G
C
A
A
A
T
G
T
A
C
A
A
G
G
T
C
A
T
T
T
C
C
T
T
T
T
0.060665
0.02544
0.054795
0.046967
0.023483
0.037182
0.003914
0.023483
0.050881
0.02544
0.052838
0.033268
0.019569
0.029354
0.043053
0.019569
0.043053
0.050881
0.037182
0.001957
0.007828
0.001957
0.017613
0.037182
0.046967
0.019569
0.033268
0.029354
0.039139
0.021526
0.037182
0.02544
1
7,965
C
A
G
G
A
C
C
A
G
G
G
G
G
A
C
C
A
G
G
A
G
G
G
C
C
A
G
A
A
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T
A
C
C
C
T
A
T
G
A
G
C
A
A
A
T
G
T
A
C
A
A
G
G
T
C
A
T
T
T
C
C
T
T
T
G
0.060665
0.02544
0.054795
0.046967
0.023483
0.037182
0.003914
0.023483
0.050881
0.02544
0.052838
0.033268
0.019569
0.029354
0.043053
0.019569
0.043053
0.050881
0.037182
0.001957
0.007828
0.001957
0.017613
0.037182
0.046967
0.019569
0.033268
0.029354
0.039139
0.021526
0.037182
0.02544
1
7,966
T
T
T
C
C
C
A
G
C
A
G
G
A
C
C
A
G
G
G
G
G
A
C
C
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C
C
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A
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T
A
T
G
A
G
C
A
A
A
T
G
T
A
C
A
A
G
G
T
C
A
A
0.054795
0.023483
0.054795
0.046967
0.021526
0.037182
0.003914
0.023483
0.050881
0.02544
0.054795
0.035225
0.019569
0.027397
0.043053
0.019569
0.04501
0.050881
0.037182
0.001957
0.007828
0.001957
0.017613
0.037182
0.046967
0.019569
0.037182
0.029354
0.039139
0.023483
0.037182
0.02544
1
7,967
C
T
T
T
C
C
C
A
G
C
A
G
G
A
C
C
A
G
G
G
G
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C
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A
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G
T
C
T
0.054795
0.023483
0.054795
0.046967
0.021526
0.037182
0.003914
0.023483
0.050881
0.02544
0.054795
0.035225
0.019569
0.027397
0.043053
0.019569
0.04501
0.050881
0.037182
0.001957
0.007828
0.001957
0.017613
0.037182
0.04501
0.019569
0.037182
0.031311
0.039139
0.023483
0.037182
0.02544
1
7,968
A
A
G
C
C
C
T
T
C
T
T
T
C
C
C
A
G
C
A
G
G
A
C
C
A
G
G
G
G
G
A
C
C
A
G
G
A
G
G
G
C
C
A
G
A
A
A
T
A
C
C
C
T
A
T
G
A
G
C
A
A
A
T
G
T
T
0.054795
0.023483
0.056751
0.046967
0.021526
0.037182
0.003914
0.02544
0.050881
0.027397
0.052838
0.033268
0.019569
0.02544
0.04501
0.019569
0.04501
0.050881
0.037182
0.001957
0.007828
0.001957
0.015656
0.039139
0.04501
0.019569
0.037182
0.031311
0.037182
0.023483
0.037182
0.02544
1
7,969
A
G
G
A
C
C
A
C
G
A
A
G
C
C
C
T
T
C
T
T
T
C
C
C
A
G
C
A
G
G
A
C
C
A
G
G
G
G
G
A
C
C
A
G
G
A
G
G
G
C
C
A
G
A
A
A
T
A
C
C
C
T
A
T
G
T
0.050881
0.023483
0.056751
0.043053
0.021526
0.037182
0.003914
0.02544
0.052838
0.031311
0.052838
0.033268
0.019569
0.02544
0.043053
0.019569
0.046967
0.048924
0.037182
0.001957
0.007828
0.001957
0.017613
0.043053
0.043053
0.019569
0.035225
0.029354
0.037182
0.02544
0.037182
0.027397
1
7,970
C
T
G
G
A
C
C
T
T
G
G
T
C
A
C
C
A
C
G
A
G
G
A
C
C
A
C
G
A
A
G
C
C
C
T
T
C
T
T
T
C
C
C
A
G
C
A
G
G
A
C
C
A
G
G
G
G
G
A
C
C
A
G
G
A
T
0.052838
0.02544
0.056751
0.041096
0.023483
0.037182
0.003914
0.02544
0.050881
0.033268
0.052838
0.029354
0.021526
0.021526
0.04501
0.019569
0.050881
0.048924
0.037182
0.001957
0.007828
0.001957
0.015656
0.039139
0.04501
0.019569
0.035225
0.031311
0.035225
0.02544
0.035225
0.029354
1
7,971
G
G
G
G
A
C
C
A
A
C
T
G
C
A
C
C
T
A
C
T
T
C
T
C
C
A
G
T
T
C
G
G
C
C
A
A
C
T
G
G
A
C
C
T
T
G
G
T
C
A
C
C
A
C
G
A
G
G
A
C
C
A
C
G
A
T
0.048924
0.019569
0.056751
0.041096
0.02544
0.033268
0.003914
0.02544
0.050881
0.039139
0.048924
0.027397
0.023483
0.021526
0.043053
0.027397
0.052838
0.050881
0.041096
0.001957
0.007828
0.001957
0.015656
0.037182
0.04501
0.017613
0.039139
0.033268
0.035225
0.023483
0.031311
0.029354
1
7,972
C
T
C
A
C
C
A
G
C
G
A
A
G
C
C
A
G
G
G
G
G
A
C
C
A
A
C
T
G
C
A
C
C
T
A
C
T
T
C
T
C
C
A
G
T
T
C
G
G
C
C
A
A
C
T
G
G
A
C
C
T
T
G
G
T
T
0.052838
0.019569
0.052838
0.043053
0.027397
0.033268
0.003914
0.02544
0.046967
0.039139
0.048924
0.027397
0.02544
0.021526
0.041096
0.029354
0.052838
0.050881
0.041096
0.001957
0.009785
0.001957
0.015656
0.039139
0.041096
0.017613
0.035225
0.033268
0.035225
0.023483
0.031311
0.031311
1
7,973
C
T
C
T
C
C
A
G
A
G
G
G
A
C
C
C
T
T
C
T
C
A
C
C
A
G
C
G
A
A
G
C
C
A
G
G
G
G
G
A
C
C
A
A
C
T
G
C
A
C
C
T
A
C
T
T
C
T
C
C
A
G
T
T
C
T
0.046967
0.015656
0.050881
0.046967
0.029354
0.031311
0.003914
0.023483
0.046967
0.039139
0.048924
0.02544
0.02544
0.023483
0.043053
0.029354
0.052838
0.050881
0.043053
0.003914
0.009785
0.001957
0.013699
0.041096
0.041096
0.019569
0.035225
0.033268
0.037182
0.023483
0.029354
0.033268
1
7,974
A
C
T
T
A
C
A
G
C
A
G
T
A
C
C
A
G
C
C
T
C
T
C
C
A
G
A
G
G
G
A
C
C
C
T
T
C
T
C
A
C
C
A
G
C
G
A
A
G
C
C
A
G
G
G
G
G
A
C
C
A
A
C
T
G
T
0.04501
0.019569
0.050881
0.041096
0.031311
0.031311
0.003914
0.027397
0.046967
0.039139
0.048924
0.023483
0.027397
0.021526
0.041096
0.031311
0.054795
0.046967
0.039139
0.003914
0.009785
0.001957
0.013699
0.043053
0.041096
0.019569
0.035225
0.033268
0.037182
0.023483
0.029354
0.037182
1
7,975
G
T
T
G
G
A
A
A
T
C
A
C
T
T
A
C
A
G
C
A
G
T
A
C
C
A
G
C
C
T
C
T
C
C
A
G
A
G
G
G
A
C
C
C
T
T
C
T
C
A
C
C
A
G
C
G
A
A
G
C
C
A
G
G
G
T
0.046967
0.019569
0.054795
0.039139
0.031311
0.029354
0.003914
0.027397
0.046967
0.041096
0.048924
0.021526
0.027397
0.021526
0.043053
0.031311
0.052838
0.04501
0.039139
0.003914
0.009785
0.001957
0.013699
0.043053
0.041096
0.019569
0.035225
0.031311
0.037182
0.021526
0.033268
0.037182
1
7,976
G
A
A
G
A
C
C
C
T
G
A
G
G
A
C
C
T
G
G
A
G
T
G
C
C
A
G
G
A
G
G
T
C
C
C
T
A
A
A
T
A
G
A
G
A
A
A
A
A
A
T
A
C
T
G
A
G
T
A
T
T
A
T
G
G
T
0.064579
0.019569
0.046967
0.04501
0.037182
0.039139
0.005871
0.031311
0.054795
0.021526
0.037182
0.048924
0.037182
0.037182
0.029354
0.043053
0.039139
0.039139
0.011742
0.001957
0.003914
0
0.02544
0.035225
0.035225
0.029354
0.017613
0.015656
0.023483
0.021526
0.046967
0.054795
1
7,977
A
G
C
A
C
C
A
A
G
A
A
G
A
C
C
C
T
G
A
G
G
A
C
C
T
G
G
A
G
T
G
C
C
A
G
G
A
G
G
T
C
C
C
T
A
A
A
T
A
G
A
G
A
A
A
A
A
A
T
A
C
T
G
A
G
T
0.060665
0.019569
0.050881
0.043053
0.037182
0.039139
0.005871
0.031311
0.056751
0.02544
0.037182
0.04501
0.037182
0.037182
0.029354
0.043053
0.039139
0.039139
0.011742
0.001957
0.003914
0
0.02544
0.035225
0.037182
0.029354
0.017613
0.015656
0.023483
0.021526
0.04501
0.054795
1
7,978
G
A
G
C
A
C
C
A
A
G
A
A
G
A
C
C
C
T
G
A
G
G
A
C
C
T
G
G
A
G
T
G
C
C
A
G
G
A
G
G
T
C
C
C
T
A
A
A
T
A
G
A
G
A
A
A
A
A
A
T
A
C
T
G
A
T
0.062622
0.019569
0.050881
0.043053
0.037182
0.039139
0.005871
0.031311
0.056751
0.02544
0.037182
0.04501
0.035225
0.037182
0.029354
0.043053
0.039139
0.039139
0.011742
0.001957
0.003914
0
0.02544
0.035225
0.037182
0.029354
0.017613
0.015656
0.023483
0.021526
0.04501
0.054795
1
7,979
G
A
G
A
C
C
C
A
G
A
A
T
A
C
C
A
G
G
A
G
C
A
C
C
A
A
G
A
A
G
A
C
C
C
T
G
A
G
G
A
C
C
T
G
G
A
G
T
G
C
C
A
G
G
A
G
G
T
C
C
C
T
A
A
A
T
0.056751
0.017613
0.054795
0.043053
0.035225
0.041096
0.005871
0.033268
0.054795
0.02544
0.039139
0.043053
0.035225
0.035225
0.027397
0.043053
0.039139
0.039139
0.011742
0.001957
0.003914
0
0.027397
0.033268
0.037182
0.029354
0.017613
0.015656
0.023483
0.02544
0.050881
0.052838
1
7,980
T
C
G
A
G
C
C
A
G
G
G
A
G
A
C
C
C
A
G
A
A
T
A
C
C
A
G
G
A
G
C
A
C
C
A
A
G
A
A
G
A
C
C
C
T
G
A
G
G
A
C
C
T
G
G
A
G
T
G
C
C
A
G
G
A
G
0.054795
0.015656
0.054795
0.041096
0.037182
0.041096
0.005871
0.035225
0.056751
0.02544
0.039139
0.043053
0.035225
0.033268
0.02544
0.046967
0.039139
0.039139
0.011742
0.001957
0.003914
0
0.029354
0.033268
0.037182
0.031311
0.015656
0.015656
0.023483
0.02544
0.048924
0.052838
1
7,981
G
A
G
G
G
C
C
G
G
C
A
A
T
G
C
C
A
A
G
A
G
G
A
C
C
A
G
G
T
T
C
A
C
C
C
T
A
A
A
C
A
G
G
C
A
G
A
G
A
A
G
A
T
A
A
A
A
T
G
A
C
A
T
T
C
T
0.046967
0.027397
0.037182
0.041096
0.041096
0.035225
0.009785
0.029354
0.039139
0.027397
0.046967
0.023483
0.027397
0.043053
0.031311
0.037182
0.041096
0.043053
0.029354
0.009785
0.007828
0
0.023483
0.041096
0.050881
0.021526
0.017613
0.021526
0.043053
0.029354
0.02544
0.050881
1
7,982
G
G
G
C
C
C
C
A
G
G
A
G
G
G
C
C
G
G
C
A
A
T
G
C
C
A
A
G
A
G
G
A
C
C
A
G
G
T
T
C
A
C
C
C
T
A
A
A
C
A
G
G
C
A
G
A
G
A
A
G
A
T
A
A
A
T
0.048924
0.027397
0.039139
0.043053
0.041096
0.035225
0.009785
0.029354
0.039139
0.029354
0.046967
0.021526
0.02544
0.043053
0.031311
0.037182
0.041096
0.041096
0.027397
0.009785
0.007828
0
0.023483
0.041096
0.050881
0.021526
0.019569
0.021526
0.041096
0.027397
0.027397
0.050881
1
7,983
G
A
C
T
C
C
A
G
G
A
C
T
A
C
C
C
A
C
A
G
C
A
C
C
A
G
G
A
G
G
A
C
C
A
C
G
G
G
C
C
C
C
A
G
G
A
G
G
G
C
C
G
G
C
A
A
T
G
C
C
A
A
G
A
G
T
0.048924
0.02544
0.041096
0.04501
0.037182
0.035225
0.007828
0.027397
0.039139
0.029354
0.046967
0.023483
0.02544
0.043053
0.035225
0.037182
0.039139
0.04501
0.029354
0.009785
0.005871
0
0.027397
0.035225
0.052838
0.019569
0.023483
0.02544
0.041096
0.02544
0.02544
0.046967
1
7,984
T
G
A
C
T
C
C
A
G
G
A
C
T
A
C
C
C
A
C
A
G
C
A
C
C
A
G
G
A
G
G
A
C
C
A
C
G
G
G
C
C
C
C
A
G
G
A
G
G
G
C
C
G
G
C
A
A
T
G
C
C
A
A
G
A
T
0.050881
0.02544
0.041096
0.04501
0.037182
0.035225
0.007828
0.027397
0.039139
0.029354
0.046967
0.023483
0.02544
0.041096
0.035225
0.037182
0.039139
0.04501
0.029354
0.009785
0.005871
0
0.027397
0.035225
0.052838
0.019569
0.023483
0.02544
0.041096
0.02544
0.02544
0.046967
1
7,985
A
C
G
A
C
C
A
G
C
T
T
C
A
C
C
A
G
G
A
G
C
A
C
C
G
T
T
G
A
C
T
C
C
A
G
G
A
C
T
A
C
C
C
A
C
A
G
C
A
C
C
A
G
G
A
G
G
A
C
C
A
C
G
G
G
T
0.056751
0.029354
0.041096
0.04501
0.037182
0.035225
0.005871
0.031311
0.041096
0.02544
0.046967
0.023483
0.021526
0.039139
0.037182
0.035225
0.039139
0.04501
0.031311
0.007828
0.005871
0
0.027397
0.035225
0.052838
0.019569
0.023483
0.02544
0.039139
0.02544
0.02544
0.04501
1
7,986
A
C
T
C
A
C
A
T
C
A
C
G
A
C
C
A
G
C
T
T
C
A
C
C
A
G
G
A
G
C
A
C
C
G
T
T
G
A
C
T
C
C
A
G
G
A
C
T
A
C
C
C
A
C
A
G
C
A
C
C
A
G
G
A
G
A
0.064579
0.029354
0.041096
0.046967
0.033268
0.035225
0.005871
0.031311
0.041096
0.02544
0.046967
0.023483
0.021526
0.035225
0.037182
0.033268
0.039139
0.043053
0.031311
0.007828
0.005871
0
0.027397
0.037182
0.052838
0.019569
0.023483
0.02544
0.039139
0.023483
0.027397
0.04501
1
7,987
G
A
C
T
C
A
C
A
T
C
A
C
G
A
C
C
A
G
C
T
T
C
A
C
C
A
G
G
A
G
C
A
C
C
G
T
T
G
A
C
T
C
C
A
G
G
A
C
T
A
C
C
C
A
C
A
G
C
A
C
C
A
G
G
A
T
0.064579
0.029354
0.041096
0.046967
0.033268
0.035225
0.005871
0.031311
0.041096
0.02544
0.046967
0.02544
0.021526
0.035225
0.037182
0.033268
0.039139
0.043053
0.031311
0.007828
0.005871
0
0.027397
0.037182
0.052838
0.019569
0.023483
0.02544
0.037182
0.023483
0.027397
0.04501
1
7,988
T
T
G
A
C
C
A
T
C
G
C
G
A
C
C
T
G
G
G
G
G
A
C
C
A
T
C
G
T
T
C
C
C
A
G
G
G
T
T
G
C
C
C
T
G
T
G
A
A
G
A
C
A
C
C
A
C
A
C
A
A
A
T
T
A
T
0.072407
0.039139
0.033268
0.035225
0.033268
0.048924
0.009785
0.027397
0.029354
0.031311
0.039139
0.021526
0.019569
0.029354
0.043053
0.037182
0.046967
0.048924
0.041096
0.011742
0.007828
0.009785
0.027397
0.019569
0.033268
0.021526
0.041096
0.031311
0.019569
0.021526
0.031311
0.037182
1
7,989
A
C
T
G
A
C
C
T
T
G
T
G
T
C
C
G
G
G
T
T
G
A
C
C
A
T
C
G
C
G
A
C
C
T
G
G
G
G
G
A
C
C
A
T
C
G
T
T
C
C
C
A
G
G
G
T
T
G
C
C
C
T
G
T
G
A
0.064579
0.039139
0.031311
0.031311
0.033268
0.048924
0.009785
0.031311
0.029354
0.031311
0.041096
0.017613
0.019569
0.029354
0.041096
0.039139
0.052838
0.048924
0.043053
0.011742
0.007828
0.009785
0.027397
0.021526
0.029354
0.023483
0.04501
0.031311
0.021526
0.021526
0.031311
0.035225
1
7,990
T
G
A
A
A
A
G
T
G
T
A
C
T
G
A
C
C
T
T
G
T
G
T
C
C
G
G
G
T
T
G
A
C
C
A
T
C
G
C
G
A
C
C
T
G
G
G
G
G
A
C
C
A
T
C
G
T
T
C
C
C
A
G
G
G
A
0.062622
0.039139
0.029354
0.031311
0.033268
0.048924
0.011742
0.031311
0.029354
0.033268
0.039139
0.017613
0.019569
0.029354
0.039139
0.041096
0.052838
0.048924
0.04501
0.011742
0.009785
0.009785
0.02544
0.023483
0.031311
0.023483
0.04501
0.029354
0.021526
0.021526
0.029354
0.035225
1