row_idx
int64
f_0_ref__32
string
f_1_ref__31
string
f_2_ref__30
string
f_3_ref__29
string
f_4_ref__28
string
f_5_ref__27
string
f_6_ref__26
string
f_7_ref__25
string
f_8_ref__24
string
f_9_ref__23
string
f_10_ref__22
string
f_11_ref__21
string
f_12_ref__20
string
f_13_ref__19
string
f_14_ref__18
string
f_15_ref__17
string
f_16_ref__16
string
f_17_ref__15
string
f_18_ref__14
string
f_19_ref__13
string
f_20_ref__12
string
f_21_ref__11
string
f_22_ref__10
string
f_23_ref__9
string
f_24_ref__8
string
f_25_ref__7
string
f_26_ref__6
string
f_27_ref__5
string
f_28_ref__4
string
f_29_ref__3
string
f_30_ref__2
string
f_31_ref__1
string
f_32_ref_0
string
f_33_ref__1
string
f_34_ref__2
string
f_35_ref__3
string
f_36_ref__4
string
f_37_ref__5
string
f_38_ref__6
string
f_39_ref__7
string
f_40_ref__8
string
f_41_ref__9
string
f_42_ref__10
string
f_43_ref__11
string
f_44_ref__12
string
f_45_ref__13
string
f_46_ref__14
string
f_47_ref__15
string
f_48_ref__16
string
f_49_ref__17
string
f_50_ref__18
string
f_51_ref__19
string
f_52_ref__20
string
f_53_ref__21
string
f_54_ref__22
string
f_55_ref__23
string
f_56_ref__24
string
f_57_ref__25
string
f_58_ref__26
string
f_59_ref__27
string
f_60_ref__28
string
f_61_ref__29
string
f_62_ref__30
string
f_63_ref__31
string
f_64_ref__32
string
f_65_alt
string
f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
8,091
G
C
T
G
C
T
T
A
G
T
G
A
C
G
T
C
A
T
T
T
C
G
G
G
A
G
T
T
A
G
T
A
C
T
G
G
G
C
T
A
G
T
G
G
C
C
A
C
G
C
T
G
C
A
A
G
G
T
A
A
G
A
T
G
T
T
0.052838
0.035225
0.048924
0.031311
0.02544
0.027397
0.005871
0.048924
0.056751
0.029354
0.039139
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0.021526
0.017613
0.04501
0.029354
0.046967
0.048924
0.031311
0.003914
0.003914
0.001957
0.031311
0.046967
0.039139
0.021526
0.035225
0.027397
0.039139
0.019569
0.031311
0.029354
1
8,092
C
C
A
A
C
A
T
C
T
T
A
C
C
T
T
G
C
A
G
C
G
T
G
G
C
C
A
C
T
A
G
C
C
C
A
G
T
A
C
T
A
A
C
T
C
C
C
G
A
A
A
T
G
A
C
G
T
C
A
C
T
A
A
G
C
T
0.052838
0.033268
0.048924
0.031311
0.02544
0.02544
0.005871
0.048924
0.056751
0.029354
0.039139
0.027397
0.021526
0.017613
0.04501
0.031311
0.046967
0.050881
0.031311
0.003914
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0.001957
0.031311
0.046967
0.039139
0.021526
0.035225
0.029354
0.039139
0.019569
0.029354
0.029354
1
8,093
C
A
C
T
T
T
G
C
A
T
G
T
G
C
T
T
T
C
A
G
G
G
A
T
G
G
C
A
T
A
T
G
C
C
C
T
A
C
T
A
G
C
T
G
C
A
G
T
T
C
C
T
G
T
C
G
G
A
T
A
T
G
G
T
C
A
0.082192
0.037182
0.046967
0.060665
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0.001957
0.050881
0.023483
0.015656
0.021526
0.080235
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0.052838
0.048924
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0.02544
0.02544
0.005871
0.005871
0.001957
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0.023483
0.013699
0.031311
0.011742
0.050881
0.009785
0.015656
0.04501
0.062622
0.037182
1
8,094
C
C
C
T
A
C
T
A
G
C
T
G
C
A
G
T
T
C
C
T
G
T
C
G
G
A
T
A
T
G
G
T
C
T
C
T
A
C
T
C
T
G
C
T
T
T
T
T
T
C
C
C
T
A
T
C
C
T
G
A
C
A
T
A
C
T
0.078278
0.039139
0.043053
0.058708
0.043053
0.027397
0
0.048924
0.023483
0.013699
0.021526
0.078278
0.021526
0.056751
0.048924
0.023483
0.029354
0.02544
0.007828
0.005871
0.001957
0.003914
0.021526
0.013699
0.033268
0.013699
0.048924
0.007828
0.017613
0.04501
0.058708
0.039139
1
8,095
A
T
A
T
A
A
T
T
G
T
A
A
A
A
T
A
T
A
C
T
T
A
T
A
A
T
T
A
C
C
A
A
C
T
G
A
G
A
T
A
T
G
T
C
T
T
G
A
T
G
T
T
C
C
A
A
A
G
A
T
A
A
A
G
T
A
0.088063
0.039139
0.046967
0.054795
0.039139
0.027397
0
0.048924
0.021526
0.015656
0.02544
0.07045
0.023483
0.050881
0.046967
0.027397
0.029354
0.02544
0.009785
0.005871
0.001957
0.003914
0.023483
0.011742
0.031311
0.013699
0.052838
0.009785
0.019569
0.035225
0.062622
0.037182
1
8,096
T
A
A
T
T
G
T
T
A
G
A
G
A
C
T
T
T
T
T
T
T
C
C
C
C
A
G
G
A
C
C
T
T
T
T
C
C
A
G
T
G
G
T
G
A
G
T
T
T
A
A
T
G
G
T
G
G
G
A
T
C
T
G
T
T
C
0.07045
0.035225
0.031311
0.048924
0.041096
0.021526
0.005871
0.043053
0.043053
0.039139
0.019569
0.043053
0.029354
0.031311
0.027397
0.027397
0.052838
0.039139
0.027397
0.007828
0.009785
0.003914
0.033268
0.027397
0.031311
0.023483
0.027397
0.015656
0.029354
0.02544
0.056751
0.031311
1
8,097
A
A
T
T
G
T
T
A
G
A
G
A
C
T
T
T
T
T
T
T
C
C
C
C
A
G
G
A
C
C
T
T
T
T
C
C
A
G
T
G
G
T
G
A
G
T
T
T
A
A
T
G
G
T
G
G
G
A
T
C
T
G
T
T
G
C
0.07045
0.035225
0.031311
0.048924
0.041096
0.021526
0.005871
0.043053
0.043053
0.039139
0.019569
0.043053
0.031311
0.031311
0.027397
0.027397
0.052838
0.039139
0.027397
0.007828
0.009785
0.003914
0.031311
0.027397
0.031311
0.023483
0.027397
0.015656
0.029354
0.02544
0.056751
0.031311
1
8,098
G
G
G
G
G
C
C
A
T
G
C
T
C
A
G
A
A
C
A
A
C
A
G
A
T
C
C
C
A
C
C
A
T
T
A
A
A
C
T
C
A
C
C
A
C
T
G
G
A
A
A
A
G
G
T
C
C
T
G
G
G
G
A
A
A
C
0.076321
0.037182
0.031311
0.050881
0.043053
0.019569
0.005871
0.043053
0.041096
0.039139
0.019569
0.041096
0.029354
0.029354
0.029354
0.027397
0.052838
0.037182
0.023483
0.007828
0.009785
0.003914
0.033268
0.02544
0.033268
0.023483
0.027397
0.015656
0.029354
0.02544
0.056751
0.031311
1
8,099
T
T
T
T
A
C
T
T
G
T
A
A
G
T
T
C
A
T
T
A
C
C
T
G
T
A
T
A
A
T
T
C
C
A
A
C
C
A
G
C
A
G
A
G
T
C
A
G
G
G
C
A
C
T
G
G
C
A
A
T
C
A
G
G
A
T
0.091977
0.035225
0.035225
0.066536
0.04501
0.019569
0.007828
0.043053
0.043053
0.02544
0.019569
0.04501
0.027397
0.031311
0.031311
0.027397
0.04501
0.029354
0.021526
0.001957
0.005871
0
0.033268
0.017613
0.035225
0.023483
0.027397
0.009785
0.021526
0.029354
0.07045
0.033268
1
8,100
T
T
G
T
G
A
A
G
C
C
A
C
C
A
A
C
C
A
A
A
G
G
A
T
C
T
G
C
C
A
A
G
T
A
C
C
T
C
A
C
T
A
T
G
A
A
T
C
C
A
A
T
C
T
G
C
A
A
G
C
C
A
C
C
A
C
0.074364
0.029354
0.041096
0.054795
0.035225
0.031311
0.003914
0.035225
0.041096
0.031311
0.037182
0.039139
0.02544
0.021526
0.048924
0.039139
0.037182
0.050881
0.015656
0.001957
0.003914
0.001957
0.033268
0.033268
0.04501
0.007828
0.02544
0.027397
0.031311
0.029354
0.031311
0.035225
1
8,101
C
A
G
C
A
C
T
T
G
G
A
A
G
G
C
A
G
C
A
G
C
T
G
T
T
G
T
G
A
A
G
C
C
A
C
C
A
A
C
C
A
A
A
G
G
A
T
C
T
G
C
C
A
A
G
T
A
C
C
T
C
A
C
T
A
T
0.066536
0.027397
0.039139
0.054795
0.033268
0.029354
0.003914
0.033268
0.043053
0.035225
0.037182
0.037182
0.027397
0.021526
0.052838
0.037182
0.041096
0.052838
0.017613
0.001957
0.003914
0.001957
0.031311
0.037182
0.04501
0.007828
0.027397
0.029354
0.033268
0.027397
0.02544
0.037182
1
8,102
T
T
T
T
G
G
T
T
G
A
A
A
C
A
T
T
G
A
G
G
A
C
A
A
T
C
T
T
T
A
G
C
T
G
T
G
A
G
A
C
C
A
G
C
A
C
T
T
G
G
A
A
G
G
C
A
G
C
A
G
C
T
G
T
T
C
0.093933
0.027397
0.039139
0.050881
0.033268
0.027397
0.007828
0.029354
0.048924
0.035225
0.033268
0.033268
0.027397
0.023483
0.050881
0.033268
0.041096
0.048924
0.011742
0.001957
0.003914
0.001957
0.027397
0.039139
0.041096
0.011742
0.027397
0.029354
0.027397
0.02544
0.027397
0.039139
1
8,103
A
T
G
T
T
T
C
A
A
C
C
A
A
A
A
A
C
T
A
C
A
A
T
G
G
A
G
T
T
C
T
C
T
C
T
A
T
T
A
T
C
T
A
T
G
T
A
A
G
T
G
T
T
G
C
T
T
C
T
T
G
C
T
C
C
C
0.113503
0.027397
0.050881
0.04501
0.031311
0.02544
0.007828
0.027397
0.058708
0.031311
0.029354
0.023483
0.031311
0.021526
0.050881
0.031311
0.037182
0.048924
0.011742
0.003914
0.005871
0.001957
0.021526
0.039139
0.048924
0.011742
0.023483
0.02544
0.031311
0.021526
0.023483
0.037182
1
8,104
A
G
A
C
G
A
C
A
A
T
G
G
T
G
A
G
C
A
A
T
C
C
A
G
C
A
G
T
G
A
A
A
T
C
A
G
C
A
A
G
A
T
T
G
G
T
A
T
C
A
C
C
A
A
T
A
T
T
T
T
G
A
A
A
A
C
0.093933
0.035225
0.021526
0.078278
0.058708
0.023483
0.011742
0.02544
0.029354
0.023483
0.011742
0.062622
0.033268
0.043053
0.052838
0.041096
0.033268
0.037182
0.005871
0.001957
0.007828
0.005871
0.019569
0.015656
0.037182
0.015656
0.031311
0.005871
0.021526
0.027397
0.04501
0.043053
1
8,105
T
G
T
A
T
T
A
G
T
A
C
T
A
A
G
A
G
G
A
A
C
A
C
C
A
C
A
C
T
C
A
C
C
C
C
C
T
T
G
G
G
A
T
G
G
A
T
T
T
A
A
C
A
A
T
G
C
C
A
G
C
A
T
T
G
T
0.099804
0.04501
0.043053
0.064579
0.052838
0.019569
0.009785
0.037182
0.031311
0.019569
0.019569
0.048924
0.021526
0.04501
0.039139
0.023483
0.027397
0.035225
0.013699
0.005871
0.003914
0
0.02544
0.011742
0.039139
0.019569
0.017613
0.013699
0.027397
0.035225
0.074364
0.029354
1
8,106
G
G
T
G
G
C
A
T
A
T
A
C
T
T
T
T
C
C
T
A
C
T
G
A
C
A
C
T
G
C
A
A
T
A
G
C
A
T
A
A
G
C
C
A
C
C
A
C
A
G
C
G
A
T
G
G
A
A
A
A
T
G
A
T
G
G
0.109589
0.029354
0.043053
0.037182
0.039139
0.033268
0.001957
0.029354
0.027397
0.039139
0.02544
0.04501
0.033268
0.048924
0.035225
0.041096
0.037182
0.046967
0.017613
0.001957
0.009785
0.001957
0.02544
0.015656
0.043053
0.013699
0.037182
0.011742
0.029354
0.019569
0.031311
0.039139
1
8,107
T
G
C
T
A
T
T
G
C
A
G
T
G
T
C
A
G
T
A
G
G
A
A
A
A
G
T
A
T
A
T
G
C
C
A
C
C
A
A
G
T
A
T
G
A
T
T
A
C
A
C
C
A
T
C
G
A
T
G
G
G
A
A
C
C
T
0.111546
0.031311
0.04501
0.043053
0.037182
0.033268
0.001957
0.031311
0.029354
0.033268
0.02544
0.043053
0.031311
0.043053
0.037182
0.043053
0.035225
0.046967
0.017613
0.001957
0.009785
0.001957
0.023483
0.015656
0.046967
0.013699
0.035225
0.011742
0.029354
0.015656
0.035225
0.039139
1
8,108
A
A
A
A
C
A
A
G
A
G
A
A
G
A
A
T
C
C
T
G
A
G
A
A
G
A
T
G
T
T
G
C
T
G
A
T
C
C
C
A
A
A
G
G
C
A
A
T
G
A
A
T
T
C
C
T
A
A
G
G
A
A
G
A
G
G
0.041096
0.021526
0.048924
0.04501
0.035225
0.02544
0.013699
0.027397
0.052838
0.019569
0.056751
0.015656
0.033268
0.027397
0.046967
0.02544
0.039139
0.035225
0.011742
0.009785
0.017613
0.009785
0.015656
0.052838
0.048924
0.027397
0.027397
0.02544
0.050881
0.027397
0.023483
0.041096
1
8,109
C
A
C
A
A
A
A
C
A
A
G
A
G
A
A
G
A
A
T
C
C
T
G
A
G
A
A
G
A
T
G
T
T
G
C
T
G
A
T
C
C
C
A
A
A
G
G
C
A
A
T
G
A
A
T
T
C
C
T
A
A
G
G
A
A
A
0.043053
0.021526
0.046967
0.046967
0.035225
0.02544
0.013699
0.027397
0.050881
0.019569
0.056751
0.015656
0.035225
0.027397
0.046967
0.02544
0.039139
0.035225
0.011742
0.009785
0.017613
0.009785
0.015656
0.052838
0.046967
0.027397
0.027397
0.02544
0.050881
0.027397
0.023483
0.041096
1
8,110
G
A
C
G
G
C
C
G
T
G
C
G
G
G
A
A
A
G
A
G
C
A
G
T
G
G
T
G
G
C
C
A
C
A
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A
A
G
A
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A
A
G
A
A
T
C
C
T
G
A
G
A
A
G
A
T
G
T
T
G
C
T
0.046967
0.02544
0.046967
0.041096
0.039139
0.027397
0.013699
0.02544
0.054795
0.017613
0.056751
0.015656
0.033268
0.031311
0.043053
0.02544
0.041096
0.037182
0.011742
0.009785
0.013699
0.009785
0.015656
0.050881
0.048924
0.02544
0.02544
0.02544
0.050881
0.029354
0.021526
0.039139
1
8,111
T
T
G
T
T
T
T
G
T
G
G
C
C
A
C
C
A
C
T
G
C
T
C
T
T
T
C
C
C
G
C
A
C
G
G
C
C
G
T
C
C
A
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G
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G
A
G
C
A
C
T
G
G
A
G
G
A
A
A
G
A
C
A
C
T
0.050881
0.02544
0.046967
0.046967
0.043053
0.023483
0.011742
0.027397
0.050881
0.017613
0.054795
0.017613
0.037182
0.027397
0.046967
0.027397
0.041096
0.033268
0.011742
0.009785
0.013699
0.007828
0.017613
0.04501
0.050881
0.021526
0.02544
0.023483
0.050881
0.029354
0.021526
0.041096
1
8,112
G
A
G
A
T
G
G
A
T
A
T
C
A
T
A
A
G
G
C
T
G
T
T
G
T
T
C
C
T
A
C
C
T
G
T
G
T
C
T
T
T
C
C
T
C
C
A
G
T
G
C
T
C
T
C
C
T
G
G
A
C
G
G
C
C
A
0.048924
0.023483
0.046967
0.046967
0.04501
0.02544
0.009785
0.027397
0.050881
0.023483
0.054795
0.017613
0.035225
0.029354
0.041096
0.031311
0.043053
0.029354
0.007828
0.009785
0.011742
0.007828
0.021526
0.043053
0.050881
0.021526
0.027397
0.023483
0.04501
0.031311
0.02544
0.043053
1
8,113
A
G
A
G
A
A
G
C
A
G
G
G
T
T
A
T
A
C
C
T
T
C
T
G
C
A
A
G
G
G
T
T
C
C
A
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A
A
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C
T
T
C
C
C
C
A
G
G
G
C
A
A
G
A
A
T
G
G
C
G
A
T
C
A
G
0.033268
0.027397
0.04501
0.037182
0.064579
0.019569
0.003914
0.021526
0.056751
0.035225
0.039139
0.029354
0.035225
0.039139
0.035225
0.037182
0.064579
0.031311
0.02544
0.003914
0.015656
0.003914
0.009785
0.033268
0.050881
0.02544
0.043053
0.019569
0.035225
0.017613
0.023483
0.037182
1
8,114
C
A
T
T
C
T
T
G
C
C
C
T
G
G
G
G
A
A
G
C
T
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T
G
G
A
A
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C
C
T
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C
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G
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A
C
C
C
T
G
C
T
T
C
T
C
T
G
C
A
T
A
C
C
G
0.033268
0.027397
0.04501
0.037182
0.064579
0.021526
0.003914
0.021526
0.054795
0.035225
0.041096
0.029354
0.033268
0.037182
0.035225
0.039139
0.064579
0.029354
0.02544
0.003914
0.015656
0.003914
0.009785
0.033268
0.050881
0.027397
0.041096
0.017613
0.035225
0.019569
0.023483
0.039139
1
8,115
G
T
C
A
C
A
C
A
G
C
T
G
C
A
T
A
A
A
C
A
T
C
C
C
T
T
T
C
A
G
G
T
T
G
G
C
A
A
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T
A
C
A
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C
A
G
C
T
G
C
C
A
A
G
A
C
C
G
A
C
T
G
C
C
C
0.031311
0.02544
0.046967
0.050881
0.041096
0.02544
0.001957
0.019569
0.058708
0.029354
0.033268
0.04501
0.041096
0.043053
0.035225
0.031311
0.054795
0.041096
0.033268
0.003914
0.009785
0.003914
0.013699
0.02544
0.052838
0.019569
0.046967
0.017613
0.035225
0.013699
0.033268
0.035225
1
8,116
T
A
T
T
T
G
G
A
C
T
G
T
T
G
A
C
T
G
T
G
G
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C
C
T
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A
G
A
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T
T
C
A
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T
T
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T
G
A
G
T
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A
C
G
T
A
A
A
A
C
C
C
A
G
A
T
T
T
C
C
T
A
A
0.093933
0.033268
0.035225
0.050881
0.043053
0.021526
0.009785
0.037182
0.048924
0.02544
0.02544
0.068493
0.033268
0.031311
0.02544
0.031311
0.039139
0.027397
0.015656
0.001957
0.003914
0
0.041096
0.02544
0.043053
0.015656
0.011742
0.013699
0.019569
0.031311
0.050881
0.04501
1
8,117
A
T
A
G
G
A
A
A
T
C
T
G
G
G
T
T
T
T
A
C
G
T
T
A
C
T
C
A
C
A
A
C
T
G
A
A
C
T
C
T
C
A
G
G
A
C
C
A
C
A
G
T
C
A
A
C
A
G
T
C
C
A
A
A
T
C
0.093933
0.033268
0.035225
0.050881
0.043053
0.021526
0.009785
0.037182
0.050881
0.02544
0.02544
0.068493
0.033268
0.031311
0.02544
0.031311
0.039139
0.027397
0.015656
0.001957
0.003914
0
0.041096
0.023483
0.043053
0.015656
0.011742
0.013699
0.019569
0.031311
0.050881
0.04501
1
8,118
A
A
A
G
G
T
A
C
T
T
A
C
G
T
T
T
T
T
G
T
A
A
T
T
C
T
T
G
G
T
A
C
T
T
T
T
G
T
A
G
A
T
A
T
C
T
G
T
G
C
T
A
G
G
G
A
T
G
C
T
T
C
C
A
A
G
0.11546
0.027397
0.046967
0.037182
0.048924
0.017613
0.009785
0.033268
0.046967
0.039139
0.029354
0.019569
0.021526
0.035225
0.041096
0.02544
0.041096
0.041096
0.021526
0.003914
0.001957
0
0.035225
0.023483
0.04501
0.027397
0.023483
0.019569
0.037182
0.029354
0.02544
0.029354
1
8,119
T
G
G
A
C
T
T
G
A
T
A
C
A
T
T
T
T
T
T
A
A
A
A
C
C
A
T
C
G
A
C
A
T
T
G
C
C
A
T
A
G
A
A
A
A
T
A
G
G
A
C
T
G
G
A
A
A
A
T
C
T
A
A
G
A
A
0.11546
0.02544
0.04501
0.068493
0.033268
0.015656
0
0.043053
0.046967
0.017613
0.035225
0.035225
0.021526
0.027397
0.043053
0.015656
0.033268
0.029354
0.023483
0
0.003914
0.003914
0.033268
0.031311
0.043053
0.019569
0.021526
0.019569
0.029354
0.031311
0.052838
0.035225
1
8,120
G
T
A
A
C
T
T
G
A
C
A
T
T
T
A
T
T
T
C
C
A
A
A
G
G
T
T
G
G
A
T
T
T
G
A
T
G
C
C
A
T
T
A
G
A
G
T
A
T
A
T
A
A
T
A
A
G
A
G
G
C
T
G
A
A
A
0.080235
0.023483
0.054795
0.050881
0.037182
0.015656
0.003914
0.029354
0.058708
0.035225
0.041096
0.04501
0.031311
0.029354
0.037182
0.011742
0.037182
0.027397
0.019569
0.001957
0
0.005871
0.033268
0.039139
0.037182
0.019569
0.017613
0.019569
0.035225
0.031311
0.054795
0.035225
1
8,121
C
T
C
C
A
A
C
A
A
C
G
T
C
C
A
G
G
A
A
A
G
A
T
A
T
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G
C
T
C
C
A
C
A
G
T
C
A
A
G
C
A
C
A
A
G
G
C
T
A
T
G
G
A
T
T
G
G
C
A
C
T
T
T
G
T
0.07045
0.033268
0.046967
0.052838
0.031311
0.019569
0.009785
0.039139
0.033268
0.035225
0.021526
0.04501
0.039139
0.031311
0.062622
0.029354
0.035225
0.052838
0.017613
0.001957
0.001957
0.001957
0.021526
0.02544
0.043053
0.013699
0.02544
0.019569
0.037182
0.023483
0.029354
0.048924
1
8,122
T
A
G
C
C
T
T
G
T
G
C
T
T
G
A
C
T
G
T
G
G
A
G
C
T
A
T
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T
C
T
T
T
C
C
T
G
G
A
C
G
T
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G
T
T
G
G
A
G
T
G
A
G
A
T
C
A
C
T
G
C
G
G
G
G
0.068493
0.033268
0.048924
0.048924
0.031311
0.021526
0.011742
0.041096
0.033268
0.035225
0.023483
0.039139
0.035225
0.029354
0.060665
0.029354
0.037182
0.052838
0.021526
0.001957
0.003914
0.001957
0.021526
0.02544
0.043053
0.015656
0.027397
0.021526
0.035225
0.02544
0.027397
0.046967
1
8,123
G
T
G
C
T
T
G
A
C
T
G
T
G
G
A
G
C
T
A
T
A
T
C
T
T
T
C
C
T
G
G
A
C
G
T
T
G
T
T
G
G
A
G
T
G
A
G
A
T
C
A
C
T
G
C
G
G
G
T
G
G
T
A
A
G
A
0.068493
0.033268
0.050881
0.046967
0.031311
0.019569
0.011742
0.041096
0.033268
0.037182
0.023483
0.039139
0.035225
0.027397
0.062622
0.029354
0.037182
0.050881
0.021526
0.001957
0.003914
0.001957
0.021526
0.02544
0.041096
0.015656
0.029354
0.021526
0.035225
0.02544
0.031311
0.04501
1
8,124
T
C
T
C
C
T
T
T
T
T
T
A
T
T
T
T
T
A
G
A
T
T
G
T
C
A
A
A
G
A
A
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T
C
C
A
A
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G
A
A
T
T
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A
T
G
T
G
A
A
T
G
T
G
T
A
T
T
T
T
G
C
A
T
C
0.078278
0.033268
0.048924
0.064579
0.041096
0.019569
0.003914
0.035225
0.041096
0.019569
0.033268
0.056751
0.031311
0.039139
0.041096
0.023483
0.037182
0.029354
0.007828
0.001957
0
0.005871
0.019569
0.023483
0.04501
0.013699
0.029354
0.011742
0.033268
0.031311
0.060665
0.039139
1
8,125
A
A
G
A
A
T
T
C
C
A
A
A
G
A
A
T
T
G
A
T
G
T
G
A
A
T
G
T
G
T
A
T
T
T
T
G
C
A
T
C
A
C
T
T
C
A
A
G
G
T
A
A
A
T
A
C
A
T
A
T
A
T
C
T
A
C
0.088063
0.033268
0.052838
0.064579
0.043053
0.017613
0.001957
0.033268
0.04501
0.017613
0.033268
0.054795
0.029354
0.039139
0.043053
0.015656
0.039139
0.029354
0.007828
0.001957
0
0.003914
0.015656
0.021526
0.046967
0.015656
0.029354
0.015656
0.031311
0.031311
0.060665
0.037182
1
8,126
G
T
C
T
T
T
C
T
T
T
T
G
A
A
G
A
T
T
A
T
G
T
G
A
T
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A
A
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C
T
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G
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C
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G
G
T
T
C
T
T
T
G
A
C
G
A
C
A
A
C
A
T
T
G
0.082192
0.035225
0.041096
0.04501
0.041096
0.027397
0.007828
0.029354
0.052838
0.031311
0.031311
0.035225
0.02544
0.043053
0.046967
0.02544
0.021526
0.027397
0.02544
0.007828
0.001957
0.005871
0.052838
0.027397
0.04501
0.02544
0.027397
0.013699
0.02544
0.019569
0.029354
0.043053
1
8,127
T
C
T
T
T
C
T
T
T
T
G
A
A
G
A
T
T
A
T
G
T
G
A
T
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A
A
A
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C
T
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C
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G
G
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C
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A
C
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A
C
A
A
C
A
T
T
A
C
0.082192
0.035225
0.041096
0.04501
0.041096
0.027397
0.007828
0.027397
0.052838
0.031311
0.031311
0.035225
0.02544
0.043053
0.046967
0.02544
0.023483
0.027397
0.02544
0.007828
0.001957
0.005871
0.052838
0.027397
0.04501
0.02544
0.027397
0.013699
0.02544
0.019569
0.029354
0.043053
1
8,128
C
G
A
C
A
A
C
A
T
T
A
G
A
A
A
G
G
A
C
A
C
A
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A
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T
A
T
A
C
T
C
T
A
T
C
T
A
C
A
G
A
A
C
C
T
0.088063
0.039139
0.039139
0.04501
0.041096
0.02544
0.007828
0.033268
0.050881
0.027397
0.031311
0.035225
0.027397
0.04501
0.046967
0.021526
0.023483
0.02544
0.019569
0.007828
0.001957
0.005871
0.052838
0.027397
0.04501
0.02544
0.023483
0.009785
0.027397
0.021526
0.031311
0.046967
1
8,129
A
C
A
T
T
A
G
A
A
A
G
G
A
C
A
C
A
T
T
C
T
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A
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T
C
T
A
T
C
T
A
C
A
G
A
A
C
C
A
A
G
T
G
G
0.088063
0.039139
0.041096
0.04501
0.039139
0.02544
0.007828
0.035225
0.052838
0.027397
0.029354
0.035225
0.027397
0.04501
0.046967
0.021526
0.021526
0.02544
0.019569
0.007828
0.001957
0.005871
0.050881
0.027397
0.046967
0.027397
0.023483
0.009785
0.027397
0.019569
0.031311
0.046967
1
8,130
A
T
C
T
T
T
C
T
T
C
A
T
C
A
A
A
A
T
A
T
G
C
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C
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G
A
A
A
A
A
T
A
T
T
G
A
G
C
T
T
T
T
C
A
T
0.119374
0.02544
0.050881
0.068493
0.031311
0.029354
0.005871
0.029354
0.039139
0.023483
0.019569
0.035225
0.033268
0.04501
0.046967
0.023483
0.02544
0.033268
0.013699
0.009785
0.001957
0.001957
0.013699
0.021526
0.048924
0.011742
0.02544
0.007828
0.023483
0.035225
0.048924
0.050881
1
8,131
A
C
G
A
T
T
C
A
C
C
C
A
C
T
G
T
T
A
A
T
T
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G
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C
C
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G
A
T
G
G
T
G
G
G
A
C
T
A
G
C
A
G
T
T
T
T
0.037182
0.027397
0.02544
0.037182
0.029354
0.037182
0.013699
0.039139
0.039139
0.021526
0.037182
0.021526
0.033268
0.033268
0.035225
0.04501
0.046967
0.048924
0.027397
0.015656
0.017613
0.015656
0.019569
0.04501
0.031311
0.029354
0.031311
0.035225
0.031311
0.017613
0.023483
0.050881
1
8,132
T
C
A
G
C
T
C
A
G
T
A
A
C
T
G
A
C
T
T
A
C
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G
A
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C
G
A
A
G
A
A
A
A
G
G
T
A
G
A
T
T
A
T
G
A
0.091977
0.021526
0.033268
0.076321
0.037182
0.02544
0.003914
0.021526
0.04501
0.02544
0.029354
0.048924
0.023483
0.046967
0.029354
0.021526
0.037182
0.039139
0.021526
0.005871
0.005871
0
0.019569
0.033268
0.035225
0.021526
0.027397
0.017613
0.031311
0.023483
0.068493
0.031311
1
8,133
T
T
T
T
A
T
C
G
T
A
G
T
T
G
A
T
G
C
T
G
A
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T
G
G
A
G
G
A
T
A
T
G
T
T
G
C
T
G
C
T
A
C
0.099804
0.039139
0.046967
0.074364
0.023483
0.021526
0.001957
0.048924
0.031311
0.029354
0.023483
0.068493
0.027397
0.033268
0.050881
0.003914
0.02544
0.021526
0.007828
0.001957
0.003914
0
0.039139
0.021526
0.035225
0.003914
0.031311
0.009785
0.015656
0.048924
0.072407
0.037182
1
8,134
A
T
T
C
A
A
G
C
A
T
G
T
T
C
C
A
C
C
A
A
G
T
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T
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A
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A
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C
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T
G
T
C
T
A
C
A
A
C
C
A
A
A
G
A
A
A
A
C
C
0.113503
0.043053
0.043053
0.064579
0.074364
0.015656
0
0.033268
0.048924
0.023483
0.009785
0.056751
0.019569
0.035225
0.054795
0.04501
0.021526
0.027397
0.005871
0.001957
0.001957
0
0.035225
0.015656
0.041096
0.019569
0.02544
0.009785
0.013699
0.015656
0.052838
0.031311
1
8,135
C
A
C
A
T
C
T
G
C
A
C
C
A
A
G
T
C
T
T
T
G
C
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A
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A
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C
A
A
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T
A
A
A
A
A
A
A
C
C
C
A
A
T
A
A
T
C
A
T
A
0.111546
0.050881
0.037182
0.066536
0.048924
0.023483
0.005871
0.033268
0.029354
0.017613
0.023483
0.050881
0.029354
0.052838
0.050881
0.011742
0.019569
0.019569
0.011742
0.001957
0.007828
0.003914
0.031311
0.015656
0.041096
0.011742
0.023483
0.005871
0.015656
0.037182
0.064579
0.04501
1
8,136
A
A
T
G
C
C
T
T
C
A
T
C
C
T
C
T
G
C
T
T
T
G
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G
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C
C
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C
A
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T
A
C
A
T
C
A
C
C
A
A
T
G
G
C
A
T
A
G
A
C
0.080235
0.035225
0.041096
0.066536
0.058708
0.029354
0
0.033268
0.031311
0.035225
0.011742
0.035225
0.02544
0.048924
0.056751
0.043053
0.039139
0.04501
0.009785
0
0
0
0.015656
0.015656
0.043053
0.009785
0.033268
0.017613
0.009785
0.033268
0.043053
0.052838
1
8,137
G
C
A
C
A
T
T
G
A
C
T
A
C
A
A
T
T
G
T
G
T
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T
G
A
A
G
T
T
G
C
T
T
G
G
G
T
T
G
G
C
A
C
0.062622
0.035225
0.041096
0.062622
0.060665
0.029354
0
0.029354
0.037182
0.041096
0.015656
0.041096
0.029354
0.046967
0.052838
0.046967
0.04501
0.041096
0.007828
0
0
0
0.015656
0.021526
0.041096
0.009785
0.037182
0.015656
0.011742
0.02544
0.043053
0.052838
1
8,138
G
T
T
A
A
T
A
A
T
T
A
C
C
G
G
A
T
G
T
G
C
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A
C
A
G
G
A
T
G
C
T
C
C
A
T
A
T
T
C
C
A
C
0.101761
0.021526
0.064579
0.072407
0.029354
0.013699
0.003914
0.013699
0.052838
0.050881
0.027397
0.050881
0.031311
0.02544
0.052838
0.013699
0.033268
0.027397
0.013699
0.003914
0
0.003914
0.027397
0.019569
0.052838
0.015656
0.033268
0.013699
0.031311
0.009785
0.052838
0.035225
1
8,139
T
G
A
A
G
A
T
A
T
A
G
C
T
A
G
A
G
T
C
T
G
T
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C
A
A
C
A
T
A
T
A
G
A
A
T
T
G
A
T
G
G
T
T
0.103718
0.021526
0.064579
0.076321
0.031311
0.013699
0.003914
0.013699
0.054795
0.046967
0.027397
0.050881
0.031311
0.02544
0.050881
0.015656
0.033268
0.023483
0.011742
0.003914
0
0.003914
0.027397
0.017613
0.056751
0.015656
0.033268
0.009785
0.031311
0.009785
0.052838
0.037182
1
8,140
T
T
T
G
C
C
A
A
A
T
G
A
C
G
C
A
G
C
A
A
G
A
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C
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C
T
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A
T
A
A
G
G
T
C
T
G
C
A
A
G
G
G
A
A
G
A
A
C
0.103718
0.019569
0.048924
0.088063
0.031311
0.015656
0.001957
0.021526
0.04501
0.037182
0.023483
0.066536
0.023483
0.033268
0.050881
0.017613
0.029354
0.029354
0.007828
0.003914
0
0.001957
0.031311
0.017613
0.054795
0.015656
0.035225
0.007828
0.033268
0.017613
0.052838
0.033268
1
8,141
G
G
T
C
A
C
A
A
T
G
C
T
G
T
C
C
T
G
T
C
A
C
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A
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C
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C
A
G
T
G
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C
C
T
G
T
C
T
C
G
G
A
A
T
C
A
C
A
A
G
G
A
A
0.07045
0.027397
0.043053
0.060665
0.060665
0.023483
0.017613
0.027397
0.037182
0.023483
0.031311
0.015656
0.031311
0.037182
0.04501
0.048924
0.033268
0.041096
0.015656
0.001957
0.005871
0.005871
0.019569
0.023483
0.041096
0.023483
0.02544
0.011742
0.039139
0.031311
0.043053
0.037182
1
8,142
A
G
T
G
G
C
T
A
A
A
G
G
G
C
T
C
T
A
G
C
C
C
C
G
G
C
A
A
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A
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G
C
C
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G
T
C
T
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C
T
G
C
C
T
T
G
G
A
A
G
G
T
G
A
G
G
A
T
C
T
0.066536
0.02544
0.041096
0.048924
0.039139
0.011742
0.011742
0.027397
0.060665
0.02544
0.037182
0.035225
0.027397
0.037182
0.041096
0.023483
0.046967
0.037182
0.021526
0.007828
0.003914
0
0.027397
0.035225
0.058708
0.023483
0.027397
0.033268
0.037182
0.017613
0.017613
0.04501
1
8,143
C
A
A
A
G
A
A
G
G
C
A
C
A
G
T
C
T
A
G
T
A
A
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C
A
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G
C
C
T
G
T
T
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C
A
A
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G
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C
T
G
G
T
A
G
A
G
T
G
T
G
T
T
T
G
C
A
G
G
T
C
0.101761
0.027397
0.035225
0.052838
0.052838
0.027397
0.003914
0.031311
0.039139
0.027397
0.041096
0.048924
0.015656
0.027397
0.037182
0.043053
0.039139
0.029354
0.013699
0
0.007828
0
0.02544
0.039139
0.02544
0.015656
0.037182
0.023483
0.021526
0.029354
0.052838
0.027397
1
8,144
G
G
A
C
A
T
T
G
G
A
A
A
A
A
T
A
A
A
G
G
T
C
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A
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T
C
T
C
A
C
T
T
T
G
T
G
G
A
A
G
T
C
T
T
T
0.099804
0.029354
0.046967
0.050881
0.031311
0.02544
0.003914
0.041096
0.050881
0.023483
0.031311
0.068493
0.021526
0.029354
0.035225
0.021526
0.031311
0.02544
0.021526
0.001957
0.001957
0.003914
0.033268
0.033268
0.050881
0.017613
0.015656
0.007828
0.02544
0.033268
0.041096
0.04501
1
8,145
T
T
A
C
A
A
T
A
T
T
C
T
C
C
C
G
A
G
G
G
T
C
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G
T
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G
G
G
T
G
A
T
G
G
T
T
G
G
A
G
G
C
C
0.107632
0.02544
0.039139
0.062622
0.035225
0.021526
0
0.046967
0.043053
0.023483
0.023483
0.046967
0.027397
0.027397
0.037182
0.029354
0.035225
0.029354
0.023483
0.005871
0.003914
0.001957
0.039139
0.023483
0.046967
0.013699
0.021526
0.015656
0.023483
0.035225
0.043053
0.041096
1
8,146
C
T
A
T
T
T
A
C
T
G
T
T
T
A
T
A
A
A
G
C
A
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T
G
G
T
T
T
G
G
G
C
T
C
T
G
A
G
G
G
T
C
G
0.082192
0.029354
0.04501
0.052838
0.04501
0.015656
0.011742
0.037182
0.043053
0.031311
0.019569
0.037182
0.035225
0.046967
0.043053
0.029354
0.033268
0.021526
0.021526
0.001957
0.005871
0.011742
0.029354
0.023483
0.033268
0.019569
0.039139
0.009785
0.015656
0.031311
0.050881
0.046967
1
8,147
G
A
A
A
T
C
T
G
T
A
T
G
G
A
A
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T
T
T
G
T
G
T
T
A
G
0.082192
0.043053
0.041096
0.060665
0.066536
0.009785
0.003914
0.031311
0.031311
0.021526
0.023483
0.031311
0.033268
0.054795
0.046967
0.031311
0.043053
0.033268
0.021526
0
0.003914
0.003914
0.009785
0.013699
0.041096
0.017613
0.035225
0.013699
0.033268
0.019569
0.056751
0.041096
1
8,148
A
C
T
T
T
G
A
T
C
T
C
A
T
T
T
A
T
G
T
A
C
A
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A
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C
C
T
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T
G
T
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T
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G
A
A
A
A
G
C
C
A
G
T
G
A
T
G
A
T
C
T
C
A
G
0.086106
0.035225
0.04501
0.068493
0.052838
0.013699
0.001957
0.027397
0.037182
0.031311
0.017613
0.054795
0.041096
0.04501
0.054795
0.019569
0.035225
0.033268
0.015656
0.001957
0.001957
0.001957
0.015656
0.017613
0.035225
0.009785
0.027397
0.017613
0.021526
0.031311
0.058708
0.043053
1
8,149
G
C
C
A
T
C
A
T
T
G
T
C
C
A
A
C
A
A
A
G
T
C
C
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A
T
G
A
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G
C
C
C
T
G
T
G
C
A
A
A
A
G
A
A
A
G
A
A
C
T
0.105675
0.035225
0.04501
0.076321
0.046967
0.021526
0.009785
0.033268
0.021526
0.019569
0.023483
0.07045
0.023483
0.041096
0.046967
0.033268
0.019569
0.027397
0.019569
0
0
0.001957
0.02544
0.005871
0.04501
0.005871
0.027397
0.009785
0.019569
0.035225
0.064579
0.039139
1
8,150
T
T
T
T
C
T
T
G
C
C
A
T
C
A
T
T
G
T
C
C
A
A
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T
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C
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A
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C
A
A
A
A
T
G
C
C
C
T
G
T
G
C
A
A
A
A
G
C
0.105675
0.035225
0.043053
0.074364
0.046967
0.021526
0.009785
0.031311
0.023483
0.021526
0.023483
0.068493
0.023483
0.041096
0.046967
0.033268
0.021526
0.027397
0.019569
0
0
0.001957
0.02544
0.009785
0.043053
0.005871
0.027397
0.011742
0.019569
0.035225
0.062622
0.039139
1
8,151
A
G
T
T
T
C
C
C
A
A
T
T
T
C
T
G
A
C
C
G
A
G
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G
A
A
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C
A
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A
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A
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T
C
A
T
C
C
C
A
A
T
G
T
C
C
T
C
T
C
G
C
C
0.060665
0.023483
0.037182
0.04501
0.035225
0.023483
0.001957
0.043053
0.039139
0.029354
0.031311
0.013699
0.033268
0.060665
0.023483
0.037182
0.043053
0.043053
0.015656
0.005871
0.013699
0.005871
0.029354
0.033268
0.048924
0.027397
0.033268
0.021526
0.035225
0.017613
0.033268
0.054795
1
8,152
T
G
G
A
G
A
T
C
T
T
C
G
A
A
A
T
T
T
C
A
T
T
C
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A
A
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T
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A
C
T
G
C
C
A
A
G
C
T
T
A
C
T
A
A
C
T
G
T
0.056751
0.019569
0.046967
0.050881
0.02544
0.023483
0
0.037182
0.043053
0.035225
0.041096
0.017613
0.031311
0.052838
0.033268
0.021526
0.039139
0.039139
0.019569
0.003914
0.013699
0.005871
0.033268
0.037182
0.054795
0.027397
0.033268
0.015656
0.04501
0.017613
0.029354
0.048924
1
8,153
T
T
T
G
C
T
T
G
C
A
A
G
A
T
A
T
T
T
C
A
T
G
C
C
T
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A
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A
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C
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G
C
C
A
A
T
A
A
G
A
T
C
T
T
T
T
A
C
A
G
A
0.078278
0.031311
0.064579
0.048924
0.043053
0.007828
0
0.039139
0.066536
0.027397
0.02544
0.029354
0.037182
0.021526
0.056751
0.019569
0.04501
0.039139
0.015656
0
0.005871
0.001957
0.017613
0.033268
0.035225
0.021526
0.029354
0.031311
0.02544
0.017613
0.052838
0.031311
1
8,154
T
T
G
G
T
C
T
T
C
A
A
G
T
A
G
C
C
A
A
A
G
G
C
A
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G
A
A
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T
C
T
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C
A
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C
A
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A
G
T
T
T
G
T
C
C
A
C
A
G
A
G
A
C
T
T
G
G
0.084149
0.029354
0.066536
0.054795
0.039139
0.007828
0
0.037182
0.068493
0.02544
0.02544
0.031311
0.039139
0.023483
0.054795
0.015656
0.039139
0.039139
0.013699
0
0.005871
0.001957
0.017613
0.033268
0.039139
0.021526
0.027397
0.027397
0.029354
0.017613
0.056751
0.027397
1
8,155
G
A
C
T
T
T
C
C
A
A
A
G
C
C
A
T
C
C
A
C
T
T
C
A
C
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G
G
C
A
G
C
T
T
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G
C
A
C
C
T
G
T
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T
T
G
T
T
G
T
G
T
A
C
A
C
T
A
T
A
G
T
A
T
C
0.111546
0.029354
0.043053
0.066536
0.046967
0.019569
0.005871
0.046967
0.037182
0.015656
0.013699
0.050881
0.027397
0.035225
0.050881
0.031311
0.037182
0.039139
0.001957
0.001957
0
0
0.017613
0.015656
0.048924
0.017613
0.015656
0.015656
0.019569
0.041096
0.043053
0.052838
1
8,156
A
A
C
G
C
T
G
G
C
C
T
T
T
T
C
C
A
G
A
G
G
C
G
A
C
C
T
C
T
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C
A
T
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G
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C
T
C
T
C
G
G
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C
G
C
T
G
G
G
G
T
C
C
C
T
G
C
T
A
G
G
G
C
C
0.076321
0.021526
0.048924
0.029354
0.021526
0.039139
0.011742
0.015656
0.046967
0.043053
0.041096
0.009785
0.009785
0.02544
0.033268
0.033268
0.039139
0.04501
0.058708
0.021526
0.011742
0.021526
0.019569
0.039139
0.048924
0.019569
0.035225
0.041096
0.029354
0.013699
0.019569
0.029354
1
8,157
C
C
C
T
A
G
C
A
G
G
G
A
C
C
C
C
A
G
C
G
C
C
C
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A
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A
G
A
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C
A
T
G
C
A
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G
G
T
C
G
C
C
T
C
T
G
G
A
A
A
A
G
G
C
C
A
G
C
G
T
T
G
A
0.076321
0.021526
0.048924
0.031311
0.021526
0.039139
0.011742
0.015656
0.046967
0.043053
0.041096
0.009785
0.009785
0.02544
0.033268
0.033268
0.039139
0.04501
0.058708
0.021526
0.011742
0.021526
0.019569
0.039139
0.048924
0.019569
0.035225
0.041096
0.027397
0.013699
0.019569
0.029354
1
8,158
C
C
C
T
A
G
C
A
G
G
G
A
C
C
C
C
A
G
C
G
C
C
C
G
A
G
A
G
A
C
C
A
T
G
C
A
G
A
G
G
T
C
G
C
C
T
C
T
G
G
A
A
A
A
G
G
C
C
A
G
C
G
T
T
G
G
0.076321
0.021526
0.048924
0.031311
0.021526
0.039139
0.011742
0.015656
0.046967
0.043053
0.041096
0.009785
0.009785
0.02544
0.033268
0.033268
0.039139
0.04501
0.058708
0.021526
0.011742
0.021526
0.019569
0.039139
0.048924
0.019569
0.035225
0.041096
0.027397
0.013699
0.019569
0.029354
1
8,159
A
C
A
A
C
G
C
T
G
G
C
C
T
T
T
T
C
C
A
G
A
G
G
C
G
A
C
C
T
C
T
G
C
A
T
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G
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C
T
C
T
C
G
G
G
C
G
C
T
G
G
G
G
T
C
C
C
T
G
C
T
A
G
G
T
0.076321
0.021526
0.048924
0.031311
0.021526
0.039139
0.011742
0.015656
0.046967
0.043053
0.041096
0.011742
0.009785
0.02544
0.033268
0.033268
0.039139
0.04501
0.058708
0.021526
0.011742
0.021526
0.019569
0.037182
0.048924
0.019569
0.035225
0.041096
0.027397
0.013699
0.019569
0.029354
1
8,160
G
A
G
G
T
C
G
C
C
T
C
T
G
G
A
A
A
A
G
G
C
C
A
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C
G
T
T
G
T
C
T
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A
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T
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C
A
G
G
T
G
A
G
A
A
G
G
T
G
G
C
C
A
A
C
T
0.074364
0.02544
0.050881
0.027397
0.023483
0.037182
0.011742
0.021526
0.050881
0.039139
0.039139
0.011742
0.011742
0.027397
0.033268
0.035225
0.039139
0.043053
0.054795
0.015656
0.011742
0.019569
0.021526
0.039139
0.050881
0.017613
0.037182
0.035225
0.02544
0.015656
0.021526
0.031311
1
8,161
G
C
C
T
C
T
G
G
A
A
A
A
G
G
C
C
A
G
C
G
T
T
G
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C
C
A
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C
A
G
G
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G
A
G
A
A
G
G
T
G
G
C
C
A
A
C
C
G
A
G
C
T
C
0.074364
0.02544
0.050881
0.029354
0.023483
0.037182
0.011742
0.019569
0.052838
0.037182
0.039139
0.011742
0.013699
0.027397
0.035225
0.033268
0.037182
0.043053
0.054795
0.015656
0.011742
0.019569
0.021526
0.041096
0.050881
0.017613
0.033268
0.035225
0.02544
0.015656
0.021526
0.033268
1
8,162
T
A
T
G
T
C
T
G
A
C
A
A
T
T
C
C
A
G
G
C
G
C
T
G
T
C
T
G
T
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T
C
C
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C
C
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C
A
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T
T
G
G
T
C
T
G
G
T
C
C
A
G
C
T
A
A
A
A
T
T
0.072407
0.021526
0.035225
0.084149
0.04501
0.015656
0
0.021526
0.058708
0.017613
0.029354
0.078278
0.033268
0.039139
0.046967
0.011742
0.039139
0.037182
0.009785
0
0
0.003914
0.021526
0.031311
0.04501
0.021526
0.011742
0.017613
0.033268
0.027397
0.048924
0.041096
1
8,163
T
T
T
C
C
A
A
T
T
T
T
T
C
A
G
A
T
A
G
A
T
T
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T
C
A
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C
A
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A
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C
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A
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T
T
T
G
G
T
A
T
A
T
G
T
C
T
G
A
C
A
A
T
C
0.068493
0.023483
0.035225
0.078278
0.041096
0.019569
0
0.017613
0.060665
0.023483
0.031311
0.080235
0.033268
0.039139
0.046967
0.007828
0.041096
0.041096
0.007828
0
0
0.003914
0.021526
0.033268
0.043053
0.017613
0.017613
0.021526
0.031311
0.029354
0.048924
0.035225
1
8,164
A
G
A
C
A
T
A
T
A
C
C
A
A
A
T
C
C
C
T
T
C
T
G
T
T
G
A
T
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C
T
G
C
T
G
A
C
A
A
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C
T
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C
T
G
A
A
A
A
A
T
T
G
G
A
A
A
G
G
T
A
T
G
A
0.066536
0.023483
0.035225
0.078278
0.041096
0.019569
0
0.017613
0.062622
0.023483
0.031311
0.076321
0.033268
0.039139
0.046967
0.009785
0.041096
0.041096
0.007828
0
0
0.003914
0.023483
0.035225
0.043053
0.017613
0.017613
0.021526
0.031311
0.029354
0.046967
0.035225
1
8,165
A
A
A
T
C
C
C
T
T
C
T
G
T
T
G
A
T
T
C
T
G
C
T
G
A
C
A
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C
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T
C
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A
A
A
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G
A
A
A
G
G
T
A
T
G
T
T
C
A
T
G
T
A
C
A
T
C
0.078278
0.023483
0.035225
0.080235
0.041096
0.017613
0
0.017613
0.062622
0.021526
0.027397
0.078278
0.033268
0.039139
0.048924
0.007828
0.037182
0.041096
0.007828
0
0
0.003914
0.021526
0.035225
0.043053
0.017613
0.017613
0.019569
0.031311
0.027397
0.048924
0.035225
1
8,166
A
T
T
G
G
T
C
C
C
A
C
T
T
T
T
T
A
T
T
C
T
T
T
T
G
C
A
G
A
G
A
A
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G
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A
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A
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A
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C
T
G
G
C
T
T
C
A
A
A
G
A
A
A
A
A
T
C
C
T
G
0.091977
0.031311
0.035225
0.066536
0.04501
0.017613
0.001957
0.029354
0.046967
0.009785
0.023483
0.072407
0.037182
0.050881
0.041096
0.031311
0.019569
0.037182
0.015656
0.001957
0.005871
0.001957
0.029354
0.027397
0.043053
0.009785
0.023483
0.015656
0.029354
0.021526
0.048924
0.037182
1
8,167
A
A
T
G
A
G
T
T
T
A
G
G
A
T
T
T
T
T
C
T
T
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A
A
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C
C
A
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C
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C
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C
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T
C
T
C
T
G
C
A
A
A
A
G
A
A
T
A
A
A
A
A
G
T
T
0.09002
0.029354
0.035225
0.066536
0.041096
0.017613
0.001957
0.031311
0.04501
0.009785
0.02544
0.074364
0.039139
0.050881
0.041096
0.029354
0.019569
0.037182
0.015656
0.001957
0.005871
0.001957
0.029354
0.027397
0.043053
0.009785
0.023483
0.015656
0.031311
0.023483
0.048924
0.037182
1
8,168
A
T
G
A
G
A
T
C
C
T
T
A
C
C
C
C
T
A
A
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A
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A
T
C
T
C
C
A
G
A
A
A
A
A
A
C
A
T
C
G
C
T
0.101761
0.033268
0.035225
0.068493
0.041096
0.019569
0.003914
0.031311
0.041096
0.011742
0.02544
0.062622
0.037182
0.043053
0.04501
0.027397
0.015656
0.039139
0.017613
0.003914
0.005871
0.001957
0.031311
0.029354
0.037182
0.011742
0.019569
0.011742
0.037182
0.023483
0.054795
0.031311
1
8,169
A
T
G
A
G
A
T
C
C
T
T
A
C
C
C
C
T
A
A
A
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A
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A
T
C
T
C
C
A
G
A
A
A
A
A
A
C
A
T
C
G
C
A
0.101761
0.033268
0.035225
0.068493
0.041096
0.019569
0.003914
0.031311
0.041096
0.011742
0.02544
0.062622
0.037182
0.043053
0.04501
0.027397
0.015656
0.039139
0.017613
0.003914
0.005871
0.001957
0.031311
0.029354
0.037182
0.011742
0.019569
0.011742
0.037182
0.023483
0.054795
0.031311
1
8,170
A
C
A
T
A
A
T
G
A
A
T
G
T
A
C
A
A
A
T
G
A
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C
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G
A
T
T
C
C
A
T
A
G
A
A
C
A
T
A
A
A
T
C
T
0.107632
0.031311
0.039139
0.074364
0.037182
0.017613
0.003914
0.029354
0.041096
0.013699
0.02544
0.064579
0.037182
0.043053
0.04501
0.023483
0.011742
0.035225
0.017613
0.003914
0.005871
0.001957
0.031311
0.027397
0.037182
0.011742
0.021526
0.009785
0.037182
0.023483
0.060665
0.029354
1
8,171
C
A
G
T
A
A
G
A
G
A
G
G
C
T
G
T
A
C
T
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C
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A
A
A
A
A
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A
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A
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A
A
A
T
T
A
A
A
T
T
T
0.074364
0.02544
0.050881
0.050881
0.037182
0.017613
0.001957
0.035225
0.046967
0.023483
0.037182
0.072407
0.021526
0.04501
0.033268
0.02544
0.023483
0.027397
0.021526
0.003914
0.003914
0.005871
0.033268
0.035225
0.04501
0.015656
0.021526
0.023483
0.027397
0.02544
0.048924
0.039139
1
8,172
A
G
G
A
A
G
C
T
A
T
G
A
T
T
C
T
T
C
C
C
A
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T
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G
T
G
A
C
T
T
C
C
T
A
C
A
A
A
A
G
G
G
G
A
C
0.076321
0.02544
0.050881
0.050881
0.041096
0.017613
0.003914
0.031311
0.046967
0.023483
0.037182
0.072407
0.023483
0.048924
0.033268
0.021526
0.021526
0.023483
0.021526
0.003914
0.005871
0.005871
0.031311
0.035225
0.043053
0.015656
0.021526
0.019569
0.027397
0.031311
0.050881
0.037182
1
8,173
C
C
T
T
T
T
G
T
A
G
G
A
A
G
T
C
A
C
C
A
A
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C
A
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A
A
G
A
A
T
C
A
T
A
G
C
T
T
C
C
T
A
T
G
G
0.076321
0.023483
0.050881
0.050881
0.043053
0.017613
0.003914
0.029354
0.046967
0.023483
0.037182
0.072407
0.023483
0.048924
0.033268
0.021526
0.021526
0.023483
0.021526
0.003914
0.005871
0.005871
0.031311
0.035225
0.043053
0.017613
0.021526
0.019569
0.027397
0.031311
0.048924
0.039139
1
8,174
C
C
T
T
T
T
G
T
A
G
G
A
A
G
T
C
A
C
C
A
A
A
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C
A
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T
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C
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C
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G
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A
A
G
A
A
T
C
A
T
A
G
C
T
T
C
C
T
A
T
G
T
0.076321
0.023483
0.050881
0.050881
0.043053
0.017613
0.003914
0.029354
0.046967
0.023483
0.037182
0.072407
0.023483
0.048924
0.033268
0.021526
0.021526
0.023483
0.021526
0.003914
0.005871
0.005871
0.031311
0.035225
0.043053
0.017613
0.021526
0.019569
0.027397
0.031311
0.048924
0.039139
1
8,175
G
G
A
A
G
T
C
A
C
C
A
A
A
G
C
A
G
T
A
C
A
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A
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A
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C
A
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A
G
C
T
T
C
C
T
A
T
G
A
C
C
C
G
G
A
T
A
G
0.074364
0.023483
0.048924
0.052838
0.043053
0.015656
0.003914
0.029354
0.046967
0.023483
0.039139
0.072407
0.023483
0.050881
0.033268
0.021526
0.021526
0.023483
0.021526
0.003914
0.005871
0.005871
0.033268
0.035225
0.043053
0.017613
0.021526
0.019569
0.027397
0.029354
0.048924
0.039139
1
8,176
C
A
A
A
G
C
A
G
T
A
C
A
G
C
C
T
C
T
C
T
T
A
C
T
G
G
G
A
A
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A
A
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C
A
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C
T
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C
C
T
A
T
G
A
C
C
C
G
G
A
T
A
A
C
A
A
G
G
A
G
G
A
0.074364
0.023483
0.048924
0.052838
0.041096
0.017613
0.003914
0.031311
0.046967
0.027397
0.037182
0.068493
0.023483
0.046967
0.033268
0.023483
0.021526
0.023483
0.021526
0.003914
0.005871
0.005871
0.035225
0.035225
0.043053
0.017613
0.021526
0.019569
0.027397
0.029354
0.048924
0.039139
1
8,177
C
G
A
T
A
G
A
G
C
G
T
T
C
C
T
C
C
T
T
G
T
T
A
T
C
C
G
G
G
T
C
A
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A
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C
T
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A
T
T
C
T
T
C
C
C
A
G
T
A
A
G
A
G
A
G
G
C
C
0.072407
0.021526
0.050881
0.052838
0.041096
0.019569
0.003914
0.031311
0.04501
0.027397
0.037182
0.068493
0.023483
0.046967
0.033268
0.023483
0.023483
0.02544
0.019569
0.003914
0.005871
0.005871
0.035225
0.033268
0.043053
0.015656
0.021526
0.019569
0.02544
0.035225
0.048924
0.039139
1
8,178
G
C
C
T
A
T
G
C
C
T
A
G
A
T
A
A
A
T
C
G
C
G
A
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T
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C
G
G
G
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C
A
T
A
G
G
A
A
G
C
T
A
T
G
A
T
0.074364
0.017613
0.050881
0.058708
0.037182
0.019569
0.003914
0.029354
0.04501
0.027397
0.039139
0.066536
0.023483
0.048924
0.029354
0.021526
0.023483
0.023483
0.021526
0.003914
0.005871
0.005871
0.033268
0.033268
0.04501
0.015656
0.021526
0.019569
0.02544
0.035225
0.052838
0.041096
1
8,179
A
T
A
A
G
C
C
T
A
T
G
C
C
T
A
G
A
T
A
A
A
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C
G
C
G
A
T
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G
A
G
C
G
T
T
C
C
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C
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T
T
A
T
C
C
G
G
G
T
C
A
T
A
G
G
A
A
G
C
T
T
0.076321
0.017613
0.048924
0.060665
0.037182
0.019569
0.003914
0.029354
0.04501
0.027397
0.039139
0.066536
0.023483
0.048924
0.027397
0.021526
0.023483
0.021526
0.019569
0.003914
0.005871
0.005871
0.033268
0.033268
0.04501
0.015656
0.021526
0.019569
0.02544
0.035225
0.056751
0.041096
1
8,180
A
T
A
A
G
C
C
T
A
T
G
C
C
T
A
G
A
T
A
A
A
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C
G
C
G
A
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A
G
C
G
T
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C
C
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C
T
T
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T
T
A
T
C
C
G
G
G
T
C
A
T
A
G
G
A
A
G
C
T
G
0.076321
0.017613
0.048924
0.060665
0.037182
0.019569
0.003914
0.029354
0.04501
0.027397
0.039139
0.066536
0.023483
0.048924
0.027397
0.021526
0.023483
0.021526
0.019569
0.003914
0.005871
0.005871
0.033268
0.033268
0.04501
0.015656
0.021526
0.019569
0.02544
0.035225
0.056751
0.041096
1
8,181
G
C
A
G
T
G
T
C
C
T
C
A
C
A
A
T
A
A
A
G
A
G
A
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C
A
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C
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C
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A
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A
A
A
T
C
G
C
G
A
T
A
G
A
G
C
G
T
T
C
C
T
0.076321
0.017613
0.043053
0.066536
0.037182
0.017613
0.003914
0.02544
0.041096
0.027397
0.043053
0.068493
0.021526
0.052838
0.021526
0.021526
0.02544
0.021526
0.019569
0.003914
0.005871
0.005871
0.035225
0.033268
0.04501
0.013699
0.02544
0.023483
0.027397
0.031311
0.060665
0.037182
1
8,182
T
T
C
C
A
A
T
G
T
G
A
T
G
A
A
G
G
C
C
A
A
A
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G
C
T
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G
G
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C
A
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G
T
C
C
T
C
A
C
A
A
T
A
A
A
G
A
G
A
A
G
G
C
0.072407
0.015656
0.04501
0.082192
0.035225
0.013699
0.003914
0.023483
0.039139
0.027397
0.043053
0.066536
0.02544
0.048924
0.02544
0.017613
0.02544
0.019569
0.017613
0.003914
0.005871
0.005871
0.029354
0.031311
0.041096
0.013699
0.02544
0.023483
0.029354
0.029354
0.076321
0.037182
1
8,183
G
G
A
C
A
C
T
G
C
T
C
C
T
A
C
A
C
C
C
A
G
C
C
A
T
T
T
T
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G
G
C
C
T
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C
A
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C
A
C
A
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T
G
G
A
A
T
G
C
A
G
A
T
G
A
G
A
A
T
A
G
C
T
G
0.068493
0.015656
0.04501
0.086106
0.035225
0.013699
0.003914
0.023483
0.039139
0.027397
0.043053
0.062622
0.027397
0.046967
0.027397
0.017613
0.027397
0.019569
0.017613
0.003914
0.005871
0.005871
0.029354
0.029354
0.041096
0.013699
0.02544
0.023483
0.029354
0.029354
0.078278
0.037182
1
8,184
C
A
A
A
C
T
A
A
A
C
A
T
A
G
C
T
A
T
T
C
T
C
A
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C
A
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C
C
A
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G
C
C
A
A
A
A
A
T
G
G
C
T
G
G
G
T
G
T
A
T
0.066536
0.015656
0.04501
0.086106
0.037182
0.013699
0.003914
0.023483
0.039139
0.027397
0.041096
0.064579
0.029354
0.046967
0.027397
0.017613
0.029354
0.019569
0.017613
0.003914
0.005871
0.005871
0.027397
0.027397
0.043053
0.011742
0.02544
0.023483
0.027397
0.031311
0.076321
0.039139
1
8,185
T
G
C
A
G
A
T
G
A
G
A
A
T
A
G
C
T
A
T
G
T
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T
A
C
T
T
C
C
T
T
G
C
A
C
A
G
G
C
C
C
C
G
0.074364
0.019569
0.041096
0.082192
0.037182
0.011742
0.003914
0.02544
0.037182
0.027397
0.043053
0.062622
0.027397
0.04501
0.02544
0.015656
0.031311
0.019569
0.015656
0.003914
0.005871
0.005871
0.031311
0.029354
0.039139
0.009785
0.027397
0.02544
0.029354
0.033268
0.080235
0.033268
1
8,186
A
T
T
A
T
C
T
A
A
C
T
T
T
C
C
A
T
T
T
T
T
C
T
T
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A
G
A
C
T
T
T
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A
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C
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G
T
C
A
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C
C
G
T
G
T
T
C
T
A
G
A
T
A
A
A
A
T
A
A
C
0.084149
0.039139
0.04501
0.088063
0.031311
0.015656
0.001957
0.041096
0.04501
0.027397
0.021526
0.084149
0.017613
0.029354
0.041096
0.007828
0.027397
0.019569
0.005871
0.003914
0
0.001957
0.046967
0.013699
0.052838
0.017613
0.019569
0.009785
0.021526
0.02544
0.078278
0.035225
1
8,187
C
A
G
G
T
T
G
T
T
G
G
A
A
A
G
G
A
G
A
C
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A
A
C
A
A
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T
T
G
T
C
C
A
A
T
A
C
T
T
A
T
T
T
T
A
T
C
T
A
G
A
A
C
A
C
G
G
C
T
T
G
A
C
A
G
0.074364
0.043053
0.048924
0.078278
0.031311
0.02544
0.001957
0.043053
0.043053
0.02544
0.023483
0.078278
0.015656
0.027397
0.04501
0.011742
0.027397
0.02544
0.009785
0.003914
0
0.001957
0.046967
0.013699
0.048924
0.019569
0.017613
0.009785
0.017613
0.027397
0.076321
0.037182
1
8,188
T
T
G
T
T
A
G
T
C
T
C
C
T
T
T
C
C
A
A
C
A
A
C
C
T
G
A
A
C
A
A
A
T
T
T
G
A
T
G
A
A
G
T
A
T
G
T
A
C
C
T
A
T
T
G
A
T
T
T
A
A
T
C
T
T
G
0.080235
0.043053
0.052838
0.082192
0.031311
0.02544
0.001957
0.039139
0.04501
0.02544
0.02544
0.074364
0.019569
0.023483
0.043053
0.011742
0.02544
0.023483
0.009785
0.003914
0
0.001957
0.043053
0.013699
0.050881
0.017613
0.013699
0.009785
0.017613
0.02544
0.084149
0.035225
1
8,189
C
T
A
A
A
A
G
A
T
T
A
A
A
T
C
A
A
T
A
G
G
T
A
C
A
T
A
C
T
T
C
A
T
C
A
A
A
T
T
T
G
T
T
C
A
G
G
T
T
G
T
T
G
G
A
A
A
G
G
A
G
A
C
T
A
C
0.078278
0.043053
0.050881
0.082192
0.031311
0.02544
0.001957
0.039139
0.04501
0.02544
0.02544
0.074364
0.019569
0.023483
0.043053
0.011742
0.027397
0.023483
0.009785
0.003914
0
0.001957
0.043053
0.013699
0.048924
0.019569
0.013699
0.009785
0.017613
0.02544
0.084149
0.037182
1
8,190
A
G
C
G
A
T
C
C
A
C
A
C
G
A
A
A
T
G
T
G
C
C
A
A
T
G
C
A
A
G
T
C
C
C
T
G
G
A
A
A
A
T
A
A
A
A
G
C
A
C
A
G
C
A
A
A
A
A
C
A
G
G
T
G
T
T
0.101761
0.033268
0.04501
0.041096
0.043053
0.017613
0.005871
0.037182
0.02544
0.033268
0.033268
0.039139
0.02544
0.046967
0.037182
0.037182
0.031311
0.031311
0.021526
0.001957
0.007828
0.003914
0.035225
0.017613
0.04501
0.013699
0.043053
0.017613
0.031311
0.019569
0.039139
0.037182
1