Datasets:
TabBioMed
/
vep_pathogenic_coding

Dataset card Data Studio Files
xet
 Community
row_idx
int64
f_0_ref__32
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
2,447
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A
C
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C
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C
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T
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2,448
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A
A
A
G
G
A
A
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2,449
A
A
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C
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C
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1
2,450
C
G
A
A
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C
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A
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A
A
A
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A
G
G
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G
C
C
C
G
C
G
G
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C
A
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C
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C
A
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C
A
C
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A
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T
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A
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A
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G
A
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A
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T
T
C
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1
2,451
G
C
T
T
G
G
C
A
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T
T
A
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T
C
A
C
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T
A
C
A
C
A
G
A
C
C
T
C
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C
A
A
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A
T
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T
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T
A
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G
C
C
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G
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1
2,452
A
C
T
T
C
G
T
T
G
T
C
T
T
G
T
G
A
A
T
A
A
G
C
C
A
G
G
C
T
T
C
G
T
G
T
T
G
G
C
C
A
T
G
C
A
G
C
T
G
C
T
C
T
A
G
A
T
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A
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C
C
0.04501
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0.033268
1
2,453
T
T
A
C
T
T
C
G
T
T
G
T
C
T
T
G
T
G
A
A
T
A
A
G
C
C
A
G
G
C
T
T
C
G
T
G
T
T
G
G
C
C
A
T
G
C
A
G
C
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T
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T
A
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C
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0.043053
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1
2,454
G
T
C
T
T
C
T
T
G
T
T
T
G
G
T
T
A
C
T
T
C
C
T
C
A
G
A
A
A
A
A
T
C
A
T
C
A
T
T
G
A
C
A
T
C
C
A
A
C
A
C
C
A
G
C
A
C
T
G
G
A
A
T
G
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A
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1
2,455
T
T
T
T
T
C
T
G
A
G
G
A
A
G
T
A
A
C
C
A
A
A
C
A
A
G
A
A
G
A
C
C
T
C
A
T
G
A
G
A
G
A
G
G
T
G
G
G
A
A
G
G
A
C
T
T
T
A
A
C
T
C
C
T
G
G
0.084149
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1
2,456
G
C
C
C
T
T
C
A
T
C
A
C
A
A
G
T
G
A
A
G
T
A
C
T
T
C
C
T
G
C
C
T
T
G
A
A
C
A
G
T
T
C
C
A
T
C
A
T
T
T
T
T
G
C
C
C
T
T
T
G
C
T
T
C
A
G
0.033268
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1
2,457
C
A
C
A
A
G
T
G
A
A
G
T
A
C
T
T
C
C
T
G
C
C
T
T
G
A
A
C
A
G
T
T
C
C
A
T
C
A
T
T
T
T
T
G
C
C
C
T
T
T
G
C
T
T
C
A
T
C
C
A
G
A
A
T
C
T
0.035225
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0.033268
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1
2,458
A
C
A
A
G
T
G
A
A
G
T
A
C
T
T
C
C
T
G
C
C
T
T
G
A
A
C
A
G
T
T
C
C
A
T
C
A
T
T
T
T
T
G
C
C
C
T
T
T
G
C
T
T
C
A
T
C
C
A
G
A
A
T
C
A
T
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1
2,459
A
C
T
T
C
C
T
G
C
C
T
T
G
A
A
C
A
G
T
T
C
C
A
T
C
A
T
T
T
T
T
G
C
C
C
T
T
T
G
C
T
T
C
A
T
C
C
A
G
A
A
T
C
A
C
G
C
C
T
A
C
C
C
A
T
T
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1
2,460
A
T
T
T
T
T
G
C
C
C
T
T
T
G
C
T
T
C
A
T
C
C
A
G
A
A
T
C
A
C
G
C
C
T
A
C
C
C
A
T
T
T
G
C
C
A
G
T
G
G
C
A
A
A
C
A
G
T
G
T
G
G
C
T
C
G
0.043053
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1
2,461
A
T
T
T
T
T
G
C
C
C
T
T
T
G
C
T
T
C
A
T
C
C
A
G
A
A
T
C
A
C
G
C
C
T
A
C
C
C
A
T
T
T
G
C
C
A
G
T
G
G
C
A
A
A
C
A
G
T
G
T
G
G
C
T
C
T
0.043053
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1
2,462
A
T
G
A
G
C
T
G
C
A
C
T
G
G
G
C
C
C
C
A
G
A
G
C
T
A
G
G
A
G
T
C
T
T
T
G
C
A
G
A
C
T
T
T
G
G
G
A
A
C
C
A
C
A
C
A
A
A
A
G
C
A
G
T
A
C
0.017613
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0.062622
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1
2,463
G
G
G
C
T
C
G
G
G
C
C
T
C
A
T
C
C
C
C
C
A
G
T
A
T
C
T
G
C
T
C
C
C
T
C
C
C
A
A
T
C
C
A
G
C
C
A
T
C
A
G
C
A
T
T
T
A
G
C
A
G
C
C
C
C
G
0.02544
0.013699
0.039139
0.015656
0.009785
0.046967
0.013699
0.019569
0.023483
0.048924
0.058708
0.009785
0.019569
0.021526
0.027397
0.029354
0.058708
0.07045
0.080235
0.031311
0.011742
0.009785
0.019569
0.033268
0.033268
0.021526
0.035225
0.066536
0.050881
0.02544
0.007828
0.021526
1
2,464
A
T
C
C
C
C
A
T
A
T
C
A
C
A
C
T
G
C
A
G
C
C
T
C
T
C
C
C
T
C
A
C
C
G
G
T
G
T
G
C
A
G
G
G
G
A
G
C
C
C
A
G
G
A
T
G
A
C
T
T
T
A
T
G
G
T
0.037182
0.02544
0.033268
0.023483
0.048924
0.029354
0.001957
0.029354
0.037182
0.035225
0.039139
0.033268
0.035225
0.052838
0.035225
0.037182
0.046967
0.04501
0.043053
0.013699
0.011742
0.003914
0.023483
0.035225
0.037182
0.021526
0.037182
0.029354
0.039139
0.02544
0.011742
0.041096
1
2,465
T
G
T
G
T
C
C
A
G
A
T
C
T
G
G
C
A
C
C
C
T
G
A
C
T
T
A
T
G
A
A
G
C
A
G
T
T
C
A
C
C
A
A
A
C
A
A
C
G
C
A
A
G
T
T
G
G
A
T
T
G
G
G
G
C
A
0.101761
0.037182
0.048924
0.082192
0.033268
0.019569
0.009785
0.035225
0.039139
0.009785
0.019569
0.04501
0.037182
0.039139
0.058708
0.023483
0.013699
0.029354
0.015656
0
0.009785
0.003914
0.02544
0.015656
0.04501
0.017613
0.023483
0.009785
0.019569
0.019569
0.062622
0.048924
1
2,466
G
C
T
G
C
G
C
C
A
G
G
A
A
A
A
G
A
C
A
A
G
G
C
T
A
A
T
T
G
G
G
C
C
C
A
A
C
T
G
C
C
C
T
G
G
A
G
T
C
A
T
C
A
A
T
G
T
G
A
G
T
G
C
A
A
G
0.09589
0.035225
0.039139
0.062622
0.056751
0.009785
0.007828
0.027397
0.023483
0.033268
0.037182
0.027397
0.015656
0.041096
0.048924
0.031311
0.04501
0.027397
0.011742
0.003914
0.007828
0.007828
0.009785
0.027397
0.043053
0.017613
0.033268
0.035225
0.023483
0.017613
0.046967
0.048924
1
2,467
T
A
T
C
A
C
T
G
A
A
G
G
A
A
T
T
C
C
C
C
A
G
C
A
G
G
A
C
A
T
G
G
T
A
C
G
A
G
T
C
A
A
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C
A
C
A
A
A
C
T
G
C
T
G
C
G
C
C
A
G
G
A
A
A
A
0.088063
0.029354
0.039139
0.062622
0.052838
0.013699
0.007828
0.027397
0.027397
0.033268
0.035225
0.027397
0.013699
0.04501
0.043053
0.029354
0.046967
0.031311
0.017613
0.003914
0.007828
0.007828
0.009785
0.027397
0.041096
0.023483
0.033268
0.035225
0.021526
0.021526
0.046967
0.048924
1
2,468
G
A
T
G
T
G
T
C
T
G
G
C
C
T
C
C
T
T
T
C
C
C
T
G
G
A
G
T
G
G
T
T
C
C
T
C
C
A
A
C
G
A
G
T
T
T
G
G
T
G
C
C
A
T
A
T
T
C
C
A
A
T
G
C
C
G
0.091977
0.035225
0.058708
0.048924
0.035225
0.027397
0.001957
0.02544
0.048924
0.043053
0.039139
0.037182
0.017613
0.021526
0.054795
0.021526
0.035225
0.039139
0.017613
0
0.003914
0.001957
0.033268
0.031311
0.04501
0.011742
0.029354
0.027397
0.023483
0.021526
0.041096
0.029354
1
2,469
C
G
T
G
A
A
C
A
T
C
A
C
C
C
A
C
A
T
T
G
C
C
A
T
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C
A
G
G
C
C
T
T
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A
G
A
G
A
G
G
A
G
T
G
T
C
T
C
T
C
C
A
G
G
T
G
A
G
T
C
C
C
C
A
C
0.027397
0.021526
0.033268
0.029354
0.033268
0.027397
0.003914
0.027397
0.035225
0.048924
0.052838
0.009785
0.021526
0.029354
0.02544
0.039139
0.07045
0.07045
0.07045
0.005871
0.003914
0.001957
0.011742
0.048924
0.031311
0.02544
0.033268
0.041096
0.058708
0.005871
0.027397
0.027397
1
2,470
C
T
G
T
T
C
T
G
C
C
A
C
A
A
G
C
T
C
C
A
C
A
G
T
C
A
C
T
T
C
C
C
C
C
T
G
C
A
G
C
A
G
C
T
G
G
A
T
G
C
T
A
G
T
G
T
T
G
C
C
C
A
G
G
T
T
0.046967
0.029354
0.043053
0.027397
0.039139
0.02544
0
0.037182
0.058708
0.043053
0.039139
0.003914
0.021526
0.031311
0.02544
0.046967
0.066536
0.054795
0.041096
0
0.003914
0
0.013699
0.054795
0.052838
0.017613
0.037182
0.02544
0.04501
0.007828
0.021526
0.039139
1
2,471
C
T
A
G
G
C
T
G
C
T
C
T
T
G
A
T
T
T
C
C
T
G
T
A
A
C
T
T
G
G
C
C
C
T
C
C
A
G
G
G
A
G
A
C
A
G
G
T
C
C
A
T
C
A
A
G
A
G
T
G
G
T
T
G
C
T
0.041096
0.02544
0.046967
0.019569
0.041096
0.039139
0.003914
0.019569
0.050881
0.017613
0.062622
0.005871
0.027397
0.048924
0.021526
0.046967
0.050881
0.064579
0.043053
0.001957
0.003914
0.005871
0.013699
0.039139
0.056751
0.027397
0.02544
0.033268
0.056751
0.005871
0.013699
0.039139
1
2,472
A
G
G
G
A
G
A
C
A
G
G
T
C
C
A
T
C
A
A
G
A
G
T
G
G
T
T
G
C
A
C
C
C
A
G
G
A
T
G
T
G
C
G
C
T
G
A
A
A
G
G
G
T
G
A
C
C
A
A
G
C
G
G
C
C
G
0.041096
0.023483
0.048924
0.021526
0.041096
0.041096
0.003914
0.015656
0.056751
0.019569
0.062622
0.009785
0.027397
0.043053
0.021526
0.043053
0.054795
0.064579
0.04501
0.001957
0.003914
0.005871
0.015656
0.037182
0.054795
0.027397
0.02544
0.031311
0.054795
0.007828
0.017613
0.031311
1
2,473
G
T
T
G
C
A
C
C
C
A
G
G
A
T
G
T
G
C
G
C
T
G
A
A
A
G
G
G
T
G
A
C
C
A
A
G
C
G
G
C
C
T
G
C
A
C
G
A
T
G
T
C
C
A
C
A
C
G
A
G
G
G
T
C
A
G
0.041096
0.021526
0.050881
0.023483
0.037182
0.043053
0.003914
0.017613
0.052838
0.021526
0.066536
0.013699
0.02544
0.043053
0.021526
0.039139
0.050881
0.060665
0.043053
0.001957
0.003914
0.005871
0.019569
0.037182
0.054795
0.02544
0.02544
0.029354
0.054795
0.013699
0.019569
0.031311
1
2,474
A
G
G
G
T
G
A
C
C
A
A
G
C
G
G
C
C
T
G
C
A
C
G
A
T
G
T
C
C
A
C
A
C
G
A
G
G
G
T
C
A
A
A
A
A
T
C
C
T
T
A
G
G
A
A
A
G
A
A
A
A
C
C
A
T
G
0.043053
0.02544
0.050881
0.023483
0.043053
0.037182
0.003914
0.021526
0.056751
0.021526
0.060665
0.013699
0.021526
0.039139
0.02544
0.039139
0.052838
0.056751
0.039139
0.001957
0.003914
0.005871
0.019569
0.037182
0.056751
0.031311
0.02544
0.029354
0.052838
0.011742
0.017613
0.031311
1
2,475
T
C
T
C
T
G
C
T
C
C
C
C
T
T
G
C
C
C
A
C
C
T
C
T
G
C
T
G
G
A
A
G
C
G
G
T
C
A
T
T
G
A
T
G
G
A
G
A
C
C
C
A
A
A
T
A
T
C
A
A
A
G
T
A
G
T
0.04501
0.019569
0.048924
0.02544
0.033268
0.02544
0.001957
0.031311
0.041096
0.043053
0.035225
0.027397
0.031311
0.050881
0.043053
0.027397
0.052838
0.048924
0.046967
0.005871
0.005871
0.005871
0.021526
0.027397
0.033268
0.027397
0.052838
0.031311
0.033268
0.017613
0.019569
0.039139
1
2,476
T
C
T
A
C
T
T
T
G
A
T
A
T
T
T
G
G
G
T
C
T
C
C
A
T
C
A
A
T
G
A
C
C
G
C
T
T
C
C
A
G
C
A
G
A
G
G
T
G
G
G
C
A
A
G
G
G
G
A
G
C
A
G
A
G
T
0.04501
0.019569
0.048924
0.02544
0.033268
0.02544
0.001957
0.031311
0.041096
0.043053
0.035225
0.027397
0.031311
0.052838
0.043053
0.027397
0.052838
0.048924
0.046967
0.005871
0.005871
0.005871
0.021526
0.027397
0.033268
0.027397
0.052838
0.031311
0.033268
0.017613
0.017613
0.039139
1
2,477
T
T
C
C
C
A
G
G
G
C
T
A
T
A
A
C
A
A
C
T
G
G
A
C
A
A
A
T
G
G
G
C
T
G
T
A
T
G
G
C
T
A
T
T
C
C
T
G
G
G
A
C
A
T
G
A
T
G
G
T
G
C
A
C
T
G
0.04501
0.023483
0.039139
0.027397
0.041096
0.033268
0.007828
0.021526
0.039139
0.052838
0.041096
0.019569
0.021526
0.029354
0.037182
0.041096
0.058708
0.050881
0.064579
0.007828
0.001957
0.005871
0.023483
0.033268
0.037182
0.019569
0.037182
0.033268
0.033268
0.019569
0.015656
0.037182
1
2,478
T
A
T
G
T
A
T
T
T
T
C
T
C
C
C
T
G
C
T
T
T
C
C
T
A
G
G
T
A
T
G
T
T
C
T
C
C
T
A
C
G
T
C
A
T
G
C
T
G
G
C
C
A
G
C
A
G
C
C
C
T
C
T
C
T
C
0.043053
0.02544
0.039139
0.015656
0.02544
0.019569
0.007828
0.029354
0.04501
0.054795
0.066536
0.015656
0.007828
0.015656
0.02544
0.027397
0.076321
0.041096
0.050881
0.009785
0.007828
0.009785
0.019569
0.060665
0.048924
0.011742
0.043053
0.056751
0.043053
0.017613
0.005871
0.033268
1
2,479
A
C
T
G
G
T
A
T
G
T
G
T
T
T
C
T
C
C
T
G
G
A
C
A
A
G
A
C
A
T
C
A
T
G
G
A
A
C
A
A
C
C
A
C
T
C
C
T
A
T
C
T
G
T
A
T
G
G
G
T
T
G
T
T
G
C
0.060665
0.037182
0.029354
0.041096
0.043053
0.033268
0
0.027397
0.02544
0.021526
0.043053
0.037182
0.037182
0.048924
0.041096
0.027397
0.04501
0.060665
0.050881
0.003914
0
0.003914
0.021526
0.023483
0.027397
0.019569
0.021526
0.027397
0.04501
0.019569
0.039139
0.037182
1
2,480
G
G
T
T
C
T
T
G
A
T
G
G
T
G
C
T
A
G
A
C
A
T
T
C
C
C
C
A
G
G
A
G
C
G
G
G
G
G
C
T
C
A
G
C
T
C
T
C
T
G
G
A
C
C
G
G
A
A
A
T
A
C
C
T
T
T
0.02544
0.023483
0.035225
0.043053
0.04501
0.027397
0.001957
0.035225
0.04501
0.041096
0.031311
0.021526
0.023483
0.037182
0.037182
0.039139
0.066536
0.050881
0.04501
0.009785
0.001957
0.005871
0.027397
0.023483
0.04501
0.023483
0.043053
0.035225
0.029354
0.021526
0.019569
0.039139
1
2,481
T
G
G
C
G
G
G
C
G
G
C
A
T
C
T
G
C
C
A
G
T
G
C
C
T
G
G
C
T
G
A
G
C
G
C
T
A
C
T
C
C
G
T
C
A
T
C
C
T
G
C
T
C
G
A
C
A
C
G
C
T
G
C
T
G
T
0.007828
0.003914
0.02544
0.011742
0.019569
0.031311
0.009785
0.02544
0.035225
0.048924
0.062622
0.003914
0.011742
0.031311
0.019569
0.048924
0.07045
0.066536
0.076321
0.019569
0.005871
0.031311
0.019569
0.056751
0.017613
0.021526
0.066536
0.068493
0.048924
0.011742
0.003914
0.017613
1
2,482
A
G
A
C
T
T
C
C
T
G
T
A
G
G
C
A
A
T
G
C
C
C
T
A
G
G
G
C
T
C
T
G
C
A
C
T
G
C
A
A
T
G
C
T
T
G
C
T
C
C
A
G
G
C
T
T
T
G
G
C
A
C
C
A
G
T
0.021526
0.013699
0.015656
0.023483
0.027397
0.035225
0.007828
0.017613
0.031311
0.035225
0.050881
0.013699
0.046967
0.068493
0.021526
0.041096
0.058708
0.082192
0.062622
0.005871
0.005871
0.003914
0.019569
0.041096
0.021526
0.023483
0.041096
0.04501
0.058708
0.009785
0.011742
0.037182
1
2,483
C
G
T
G
C
A
G
T
A
T
T
C
C
T
C
C
G
C
T
T
C
C
A
A
T
A
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C
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T
C
T
T
G
G
C
T
T
T
C
A
A
G
T
G
T
T
C
A
G
0.064579
0.035225
0.04501
0.02544
0.043053
0.02544
0.009785
0.043053
0.029354
0.033268
0.043053
0.02544
0.019569
0.011742
0.048924
0.039139
0.056751
0.048924
0.029354
0.009785
0.011742
0.011742
0.003914
0.043053
0.031311
0.027397
0.033268
0.027397
0.048924
0.019569
0.023483
0.031311
1
2,484
C
A
G
C
T
C
A
C
T
C
T
G
G
G
G
G
A
A
A
T
G
G
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C
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G
T
C
G
G
C
A
T
T
A
T
A
G
G
C
C
T
T
G
C
G
0.019569
0.015656
0.033268
0.013699
0.023483
0.035225
0.017613
0.033268
0.02544
0.039139
0.052838
0.007828
0.021526
0.035225
0.023483
0.048924
0.068493
0.064579
0.056751
0.023483
0.009785
0.007828
0.017613
0.031311
0.027397
0.031311
0.048924
0.068493
0.037182
0.011742
0.009785
0.039139
1
2,485
G
C
T
G
T
C
T
C
C
C
T
A
C
A
C
A
A
A
A
G
G
C
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T
G
T
A
C
A
T
C
C
C
A
C
G
C
T
A
T
C
T
T
G
0.078278
0.02544
0.046967
0.039139
0.048924
0.017613
0.009785
0.027397
0.054795
0.027397
0.046967
0.033268
0.019569
0.037182
0.033268
0.041096
0.037182
0.027397
0.015656
0.003914
0.001957
0.003914
0.027397
0.04501
0.04501
0.017613
0.039139
0.023483
0.037182
0.021526
0.033268
0.033268
1
2,486
C
T
C
C
T
G
G
A
G
T
A
C
T
T
A
C
C
A
A
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G
C
T
G
T
G
G
T
G
A
A
A
A
G
T
G
C
A
A
G
0.050881
0.033268
0.04501
0.033268
0.041096
0.02544
0.007828
0.029354
0.039139
0.039139
0.046967
0.033268
0.023483
0.027397
0.037182
0.029354
0.060665
0.046967
0.035225
0.007828
0
0.003914
0.017613
0.029354
0.041096
0.023483
0.035225
0.027397
0.046967
0.017613
0.033268
0.031311
1
2,487
T
T
C
T
G
T
T
T
C
A
A
C
A
G
G
T
C
A
A
A
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C
A
C
T
T
T
T
C
A
C
C
A
C
A
G
C
A
G
A
G
C
0.050881
0.035225
0.04501
0.029354
0.04501
0.027397
0.007828
0.029354
0.035225
0.037182
0.050881
0.02544
0.021526
0.027397
0.039139
0.031311
0.064579
0.046967
0.031311
0.007828
0
0.003914
0.015656
0.029354
0.043053
0.02544
0.033268
0.031311
0.046967
0.017613
0.027397
0.037182
1
2,488
T
C
C
C
T
C
C
A
G
G
C
T
T
A
T
A
T
T
T
G
G
C
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A
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C
T
A
C
A
A
G
G
C
T
G
T
G
A
A
A
T
C
A
A
T
0.058708
0.017613
0.048924
0.037182
0.039139
0.027397
0.009785
0.017613
0.050881
0.035225
0.056751
0.031311
0.017613
0.031311
0.027397
0.037182
0.04501
0.033268
0.041096
0.003914
0.007828
0.005871
0.023483
0.043053
0.046967
0.023483
0.033268
0.029354
0.037182
0.015656
0.031311
0.035225
1
2,489
G
G
A
G
T
T
G
C
T
C
A
G
G
G
C
C
G
A
G
C
A
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G
C
G
G
A
A
G
T
C
G
C
T
C
A
G
G
G
T
G
A
T
0.015656
0.027397
0.033268
0.003914
0.02544
0.041096
0.015656
0.02544
0.02544
0.050881
0.052838
0.007828
0.009785
0.009785
0.023483
0.037182
0.056751
0.050881
0.052838
0.043053
0.031311
0.054795
0.013699
0.048924
0.035225
0.031311
0.027397
0.062622
0.04501
0.011742
0.005871
0.023483
1
2,490
T
T
G
A
C
A
A
T
G
G
G
A
A
C
T
T
C
C
G
T
C
G
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C
T
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C
C
A
G
C
A
A
T
G
G
C
T
C
C
A
C
A
G
T
G
T
0.035225
0.013699
0.050881
0.035225
0.021526
0.019569
0.001957
0.033268
0.064579
0.04501
0.04501
0.007828
0.019569
0.027397
0.035225
0.02544
0.048924
0.043053
0.039139
0.015656
0.011742
0.009785
0.007828
0.082192
0.052838
0.02544
0.02544
0.029354
0.056751
0.011742
0.011742
0.046967
1
2,491
G
C
G
A
G
A
A
A
A
T
G
T
T
T
G
A
C
A
A
T
G
G
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A
A
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C
C
G
T
C
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A
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C
G
C
C
G
C
T
C
T
G
A
G
G
C
C
A
G
C
A
A
T
T
0.037182
0.015656
0.050881
0.035225
0.021526
0.019569
0.001957
0.031311
0.068493
0.04501
0.043053
0.007828
0.021526
0.029354
0.035225
0.023483
0.048924
0.04501
0.039139
0.015656
0.011742
0.009785
0.007828
0.080235
0.054795
0.023483
0.02544
0.029354
0.054795
0.011742
0.011742
0.043053
1
2,492
A
A
C
T
G
C
G
A
G
A
A
A
A
T
G
T
T
T
G
A
C
A
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G
G
A
A
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C
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T
C
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A
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A
A
G
C
G
C
C
G
C
T
C
T
G
A
G
G
C
C
A
G
A
0.037182
0.017613
0.050881
0.035225
0.023483
0.019569
0.001957
0.031311
0.07045
0.041096
0.043053
0.007828
0.021526
0.029354
0.035225
0.023483
0.046967
0.04501
0.039139
0.015656
0.011742
0.009785
0.007828
0.078278
0.056751
0.023483
0.02544
0.029354
0.054795
0.011742
0.011742
0.043053
1
2,493
C
G
A
A
C
T
G
C
G
A
G
A
A
A
A
T
G
T
T
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G
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G
A
A
A
G
C
G
C
C
G
C
T
C
T
G
A
G
G
C
C
G
0.037182
0.017613
0.050881
0.035225
0.023483
0.019569
0.001957
0.031311
0.07045
0.041096
0.043053
0.007828
0.021526
0.029354
0.035225
0.023483
0.048924
0.046967
0.039139
0.015656
0.011742
0.009785
0.007828
0.076321
0.056751
0.023483
0.02544
0.029354
0.054795
0.011742
0.011742
0.041096
1
2,494
A
T
T
C
A
G
A
T
G
G
T
T
G
T
A
T
T
T
T
A
T
A
A
G
A
C
T
C
T
T
A
C
C
G
T
G
A
T
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T
A
T
A
T
C
C
A
G
A
G
T
T
T
T
T
T
A
T
G
T
C
A
T
T
C
T
0.123288
0.041096
0.052838
0.064579
0.035225
0.02544
0.001957
0.04501
0.035225
0.027397
0.021526
0.076321
0.02544
0.02544
0.029354
0.023483
0.031311
0.017613
0.005871
0.001957
0
0
0.033268
0.011742
0.04501
0.011742
0.011742
0.003914
0.011742
0.029354
0.084149
0.046967
1
2,495
G
A
T
C
G
T
G
G
T
T
G
C
T
C
T
T
C
C
C
T
G
T
C
C
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C
C
G
C
A
G
G
C
C
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C
C
A
G
C
T
C
A
T
C
C
T
G
C
A
G
T
A
T
G
G
C
T
T
G
A
C
C
C
T
0.043053
0.023483
0.043053
0.029354
0.027397
0.031311
0.005871
0.033268
0.043053
0.041096
0.043053
0.011742
0.033268
0.035225
0.037182
0.029354
0.054795
0.056751
0.033268
0.007828
0.011742
0.009785
0.017613
0.04501
0.037182
0.02544
0.029354
0.033268
0.04501
0.019569
0.021526
0.041096
1
2,496
A
T
T
G
G
G
A
T
G
A
C
C
T
C
G
A
T
G
G
G
G
A
T
T
C
C
C
T
T
G
T
G
C
C
A
C
T
G
A
T
C
C
C
C
G
A
G
A
T
T
C
T
T
C
G
A
A
T
C
T
T
T
C
C
T
G
0.066536
0.029354
0.039139
0.054795
0.048924
0.023483
0.001957
0.027397
0.019569
0.035225
0.037182
0.039139
0.02544
0.029354
0.046967
0.043053
0.043053
0.046967
0.043053
0.007828
0.015656
0.001957
0.013699
0.023483
0.04501
0.013699
0.023483
0.037182
0.029354
0.015656
0.029354
0.043053
1
2,497
A
T
A
A
C
T
T
C
T
A
T
C
C
C
A
G
A
G
A
G
G
C
C
A
A
A
G
T
A
C
A
G
T
G
G
A
A
G
G
T
G
G
A
T
A
A
C
G
C
C
C
T
C
C
A
A
T
C
G
G
G
T
A
A
C
G
0.02544
0.037182
0.037182
0.011742
0.052838
0.019569
0.009785
0.031311
0.046967
0.043053
0.052838
0.015656
0.029354
0.021526
0.029354
0.039139
0.076321
0.033268
0.046967
0.007828
0.007828
0.013699
0.013699
0.046967
0.033268
0.023483
0.04501
0.031311
0.04501
0.013699
0.023483
0.035225
1
2,498
A
T
A
A
C
T
T
C
T
A
T
C
C
C
A
G
A
G
A
G
G
C
C
A
A
A
G
T
A
C
A
G
T
G
G
A
A
G
G
T
G
G
A
T
A
A
C
G
C
C
C
T
C
C
A
A
T
C
G
G
G
T
A
A
C
C
0.02544
0.037182
0.037182
0.011742
0.052838
0.019569
0.009785
0.031311
0.046967
0.043053
0.052838
0.015656
0.029354
0.021526
0.029354
0.039139
0.076321
0.033268
0.046967
0.007828
0.007828
0.013699
0.013699
0.046967
0.033268
0.023483
0.04501
0.031311
0.04501
0.013699
0.023483
0.035225
1
2,499
C
C
G
C
C
G
G
G
C
A
G
C
C
C
T
G
C
G
C
C
T
C
C
G
G
G
G
G
C
G
T
A
C
A
T
G
C
C
C
G
G
G
G
C
C
G
C
C
C
G
C
C
G
T
C
G
C
T
C
C
G
C
A
G
T
T
0.001957
0.013699
0.005871
0.005871
0.023483
0.033268
0.021526
0.011742
0.015656
0.050881
0.050881
0.007828
0.007828
0.009785
0.011742
0.029354
0.066536
0.027397
0.091977
0.091977
0.023483
0.076321
0.009785
0.046967
0.013699
0.041096
0.050881
0.082192
0.054795
0.005871
0
0.015656
1
2,500
G
A
C
T
G
C
G
G
A
G
C
G
A
C
G
G
C
G
G
G
C
G
G
C
C
C
C
G
G
G
C
A
T
G
T
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C
G
C
C
C
C
C
G
G
A
G
G
C
G
C
A
G
G
G
C
T
G
C
C
C
G
G
C
G
A
0.001957
0.013699
0.005871
0.005871
0.023483
0.033268
0.021526
0.011742
0.015656
0.050881
0.050881
0.007828
0.007828
0.009785
0.011742
0.029354
0.066536
0.027397
0.091977
0.091977
0.02544
0.074364
0.009785
0.046967
0.013699
0.041096
0.050881
0.082192
0.054795
0.005871
0
0.015656
1
2,501
G
C
C
G
G
G
C
A
G
C
C
C
T
G
C
G
C
C
T
C
C
G
G
G
G
G
C
G
T
A
C
A
T
G
C
C
C
G
G
G
G
C
C
G
C
C
C
G
C
C
G
T
C
G
C
T
C
C
G
C
A
G
T
C
G
A
0.001957
0.013699
0.005871
0.005871
0.023483
0.033268
0.021526
0.011742
0.015656
0.050881
0.050881
0.007828
0.007828
0.009785
0.011742
0.029354
0.066536
0.027397
0.091977
0.091977
0.02544
0.072407
0.009785
0.046967
0.015656
0.041096
0.050881
0.082192
0.054795
0.005871
0
0.015656
1
2,502
T
C
A
G
G
A
C
A
A
T
T
T
C
A
A
A
T
A
T
C
G
C
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C
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C
A
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C
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A
A
G
C
A
A
A
G
A
A
G
C
A
G
C
A
T
T
C
C
A
0.023483
0.031311
0.041096
0.019569
0.037182
0.046967
0.007828
0.027397
0.041096
0.033268
0.04501
0.013699
0.027397
0.041096
0.037182
0.037182
0.048924
0.041096
0.04501
0.019569
0.017613
0.009785
0.015656
0.041096
0.031311
0.035225
0.043053
0.027397
0.031311
0.013699
0.023483
0.04501
1
2,503
T
T
A
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A
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T
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C
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G
A
T
G
C
G
A
G
C
G
A
T
A
T
T
T
G
A
A
A
T
0.027397
0.031311
0.041096
0.021526
0.035225
0.04501
0.007828
0.027397
0.039139
0.033268
0.043053
0.013699
0.029354
0.04501
0.037182
0.035225
0.046967
0.039139
0.043053
0.019569
0.017613
0.009785
0.015656
0.039139
0.031311
0.035225
0.043053
0.027397
0.031311
0.013699
0.027397
0.046967
1
2,504
G
G
G
A
G
C
T
A
C
A
G
T
A
C
T
A
C
C
T
G
T
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T
T
G
A
A
A
G
C
C
A
G
A
T
G
G
T
T
T
C
A
G
0.021526
0.017613
0.041096
0.027397
0.035225
0.031311
0.007828
0.021526
0.050881
0.041096
0.046967
0.017613
0.041096
0.046967
0.039139
0.023483
0.058708
0.037182
0.041096
0.011742
0.007828
0.007828
0.033268
0.027397
0.041096
0.031311
0.054795
0.021526
0.043053
0.023483
0.007828
0.041096
1
2,505
C
A
C
G
A
G
T
G
T
T
C
G
G
T
C
A
A
C
C
C
T
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A
A
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G
C
C
A
T
A
A
G
G
C
A
G
A
A
G
A
T
T
0.029354
0.035225
0.041096
0.02544
0.043053
0.035225
0.005871
0.02544
0.037182
0.037182
0.054795
0.029354
0.027397
0.039139
0.041096
0.031311
0.04501
0.048924
0.041096
0.005871
0.005871
0.005871
0.02544
0.041096
0.033268
0.02544
0.029354
0.02544
0.048924
0.017613
0.027397
0.035225
1
2,506
T
G
T
G
A
T
A
C
C
C
A
C
A
T
A
T
G
T
C
T
G
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A
G
A
A
G
T
T
C
A
A
C
A
G
T
T
A
G
A
C
A
A
0.088063
0.035225
0.046967
0.04501
0.035225
0.029354
0.007828
0.02544
0.052838
0.023483
0.027397
0.037182
0.031311
0.039139
0.043053
0.027397
0.039139
0.046967
0.031311
0.003914
0.005871
0.001957
0.017613
0.02544
0.058708
0.021526
0.019569
0.017613
0.031311
0.013699
0.023483
0.046967
1
2,507
C
A
G
T
T
T
C
T
T
C
T
C
T
C
T
C
T
G
T
G
T
T
C
A
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A
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G
A
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C
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C
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G
A
C
A
G
C
A
G
C
C
T
C
A
T
T
T
G
A
T
G
T
0.084149
0.029354
0.02544
0.029354
0.039139
0.021526
0.003914
0.043053
0.056751
0.02544
0.027397
0.019569
0.023483
0.04501
0.033268
0.035225
0.060665
0.046967
0.027397
0.005871
0.003914
0.003914
0.009785
0.056751
0.035225
0.019569
0.043053
0.029354
0.029354
0.023483
0.017613
0.04501
1
2,508
C
A
C
C
C
T
G
G
T
A
G
G
G
C
T
T
C
G
A
C
A
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C
G
A
A
C
G
T
T
T
G
A
C
C
C
G
C
C
C
C
G
T
0.029354
0.023483
0.041096
0.005871
0.017613
0.037182
0.023483
0.027397
0.021526
0.033268
0.048924
0.001957
0.013699
0.013699
0.031311
0.033268
0.046967
0.060665
0.088063
0.037182
0.039139
0.035225
0.009785
0.033268
0.033268
0.035225
0.027397
0.076321
0.035225
0.013699
0.005871
0.019569
1
2,509
T
A
C
G
G
T
G
C
T
G
C
T
G
G
T
G
C
T
G
T
C
G
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A
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C
G
G
G
C
T
T
A
T
G
G
C
C
C
T
G
G
A
C
C
A
0.005871
0.021526
0.023483
0.015656
0.021526
0.039139
0.02544
0.013699
0.031311
0.050881
0.050881
0.009785
0.015656
0.037182
0.029354
0.04501
0.048924
0.054795
0.041096
0.043053
0.017613
0.023483
0.013699
0.062622
0.02544
0.027397
0.056751
0.056751
0.052838
0.005871
0.005871
0.027397
1
2,510
C
T
T
C
C
C
C
C
T
C
A
G
T
T
T
T
C
C
C
A
T
T
A
G
C
A
A
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C
T
C
C
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A
C
T
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C
T
G
G
G
C
C
A
G
G
A
G
A
T
T
C
G
C
A
C
T
G
C
0.027397
0.02544
0.027397
0.019569
0.027397
0.037182
0.011742
0.019569
0.029354
0.041096
0.054795
0.019569
0.037182
0.048924
0.031311
0.031311
0.039139
0.052838
0.039139
0.02544
0.015656
0.011742
0.023483
0.054795
0.031311
0.02544
0.029354
0.035225
0.062622
0.013699
0.009785
0.041096
1
2,511
T
A
T
T
G
G
A
C
T
G
C
T
C
G
T
C
T
T
C
G
A
A
C
A
C
C
G
G
G
A
T
G
C
G
A
G
T
A
T
A
G
C
C
G
C
T
T
T
C
C
A
T
T
A
T
C
T
C
C
G
A
C
A
T
G
A
0.033268
0.02544
0.043053
0.017613
0.029354
0.031311
0.015656
0.031311
0.039139
0.031311
0.039139
0.031311
0.035225
0.041096
0.035225
0.029354
0.039139
0.048924
0.037182
0.023483
0.019569
0.015656
0.017613
0.041096
0.039139
0.037182
0.027397
0.02544
0.054795
0.015656
0.009785
0.039139
1
2,512
T
C
T
C
C
T
C
G
A
T
C
A
C
G
T
C
C
T
C
C
A
G
G
G
T
G
A
C
C
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C
C
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A
G
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A
C
C
T
C
G
T
A
G
A
A
G
G
G
G
T
C
A
C
C
C
T
C
A
C
C
C
T
0.037182
0.021526
0.031311
0.005871
0.027397
0.037182
0.019569
0.031311
0.031311
0.027397
0.068493
0.007828
0.027397
0.033268
0.023483
0.037182
0.062622
0.054795
0.054795
0.011742
0.019569
0
0.019569
0.043053
0.023483
0.046967
0.039139
0.043053
0.054795
0.011742
0.011742
0.035225
1
2,513
T
A
C
G
A
G
G
T
C
C
T
G
G
G
C
C
T
G
G
T
C
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G
G
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A
T
C
A
T
C
A
A
G
T
C
G
G
A
G
A
T
C
C
T
A
0.027397
0.019569
0.031311
0.005871
0.027397
0.039139
0.019569
0.031311
0.031311
0.02544
0.072407
0.005871
0.027397
0.031311
0.023483
0.039139
0.064579
0.054795
0.056751
0.013699
0.021526
0
0.019569
0.04501
0.021526
0.046967
0.039139
0.048924
0.052838
0.011742
0.009785
0.035225
1
2,514
G
C
G
A
G
T
T
C
T
A
C
T
C
G
C
G
C
G
A
C
C
C
C
G
A
C
G
G
G
C
T
G
C
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C
T
G
C
A
A
C
C
T
G
C
G
C
A
A
G
C
C
G
T
G
C
A
A
C
C
G
G
C
C
G
T
0.013699
0.009785
0.029354
0.003914
0.007828
0.027397
0.035225
0.017613
0.029354
0.054795
0.041096
0.003914
0.007828
0.019569
0.015656
0.041096
0.052838
0.04501
0.062622
0.048924
0.04501
0.074364
0.011742
0.050881
0.027397
0.031311
0.066536
0.074364
0.033268
0.007828
0
0.009785
1
2,515
T
G
C
T
C
C
C
A
C
C
A
C
G
G
C
A
G
G
G
G
C
G
G
C
C
A
T
A
C
T
T
G
C
G
C
A
T
G
C
G
G
T
A
C
A
C
G
C
C
C
T
G
G
C
G
C
A
C
T
G
A
G
C
C
A
G
0.007828
0.019569
0.021526
0.003914
0.037182
0.027397
0.023483
0.019569
0.023483
0.058708
0.046967
0.009785
0.009785
0.023483
0.023483
0.04501
0.07045
0.050881
0.091977
0.033268
0.009785
0.039139
0.003914
0.052838
0.017613
0.029354
0.046967
0.058708
0.048924
0.013699
0.003914
0.027397
1
2,516
C
C
C
G
A
A
T
G
C
A
T
C
A
A
C
T
T
C
C
G
C
A
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G
T
T
C
T
C
C
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C
C
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C
A
G
C
G
A
T
G
T
C
T
G
G
A
G
C
T
A
T
G
G
G
G
T
C
A
C
C
A
T
A
0.005871
0.011742
0.031311
0.001957
0.027397
0.037182
0.013699
0.031311
0.027397
0.041096
0.052838
0.001957
0.02544
0.029354
0.021526
0.046967
0.060665
0.054795
0.072407
0.037182
0.017613
0.029354
0.013699
0.046967
0.017613
0.029354
0.046967
0.066536
0.043053
0.021526
0.005871
0.029354
1
2,517
A
G
A
T
G
G
T
A
T
A
A
A
T
A
G
G
A
A
T
T
T
C
C
T
G
A
A
A
A
C
G
T
T
T
G
A
C
C
T
G
G
T
C
T
A
T
A
A
C
T
G
T
T
T
C
A
G
G
T
G
G
C
T
G
A
G
0.076321
0.033268
0.043053
0.048924
0.029354
0.031311
0.007828
0.029354
0.052838
0.023483
0.037182
0.037182
0.027397
0.031311
0.043053
0.017613
0.041096
0.046967
0.031311
0.001957
0.007828
0.001957
0.015656
0.043053
0.048924
0.015656
0.017613
0.019569
0.035225
0.031311
0.033268
0.039139
1
2,518
T
C
A
G
C
C
A
G
C
G
G
T
A
G
T
A
C
A
G
G
T
T
G
C
T
G
G
A
C
G
G
G
T
C
C
A
C
C
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C
G
A
T
C
G
C
A
T
C
C
T
T
C
T
T
T
T
T
C
G
T
C
T
T
C
A
0.035225
0.019569
0.041096
0.009785
0.033268
0.04501
0.007828
0.021526
0.041096
0.037182
0.076321
0.013699
0.011742
0.011742
0.021526
0.035225
0.060665
0.056751
0.056751
0.013699
0.013699
0.015656
0.023483
0.050881
0.031311
0.033268
0.027397
0.04501
0.056751
0.019569
0.017613
0.015656
1
2,519
G
A
C
G
A
A
A
A
A
G
A
A
G
G
A
T
G
C
G
A
T
C
G
T
G
G
T
G
G
A
C
C
C
G
T
C
C
A
G
C
A
A
C
C
T
G
T
A
C
T
A
C
C
G
C
T
G
G
C
T
G
A
C
C
G
T
0.035225
0.019569
0.041096
0.009785
0.033268
0.04501
0.007828
0.021526
0.041096
0.037182
0.076321
0.013699
0.013699
0.013699
0.021526
0.035225
0.060665
0.054795
0.054795
0.013699
0.013699
0.015656
0.023483
0.050881
0.031311
0.033268
0.027397
0.04501
0.054795
0.019569
0.017613
0.017613
1
2,520
T
C
G
C
T
T
A
C
C
T
G
C
A
A
A
T
A
A
G
C
A
G
A
T
A
C
C
A
G
T
T
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T
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A
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C
A
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G
C
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G
G
G
C
G
A
T
G
G
C
G
G
T
C
A
G
C
C
A
G
C
0.037182
0.021526
0.041096
0.013699
0.035225
0.04501
0.007828
0.019569
0.037182
0.043053
0.066536
0.013699
0.013699
0.017613
0.023483
0.041096
0.060665
0.056751
0.058708
0.013699
0.013699
0.015656
0.019569
0.04501
0.033268
0.029354
0.029354
0.041096
0.050881
0.015656
0.017613
0.021526
1
2,521
C
C
T
G
C
C
T
G
T
C
T
T
C
T
A
T
A
A
C
T
G
G
T
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C
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T
T
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C
A
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G
T
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A
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C
G
A
C
A
G
G
G
G
T
G
G
A
A
G
G
T
G
C
A
G
C
0.037182
0.021526
0.041096
0.013699
0.035225
0.04501
0.007828
0.019569
0.037182
0.043053
0.062622
0.013699
0.013699
0.017613
0.023483
0.04501
0.060665
0.056751
0.058708
0.015656
0.015656
0.015656
0.017613
0.043053
0.035225
0.027397
0.031311
0.046967
0.04501
0.013699
0.017613
0.021526
1
2,522
G
C
A
T
C
A
G
G
T
A
C
T
C
G
G
A
C
T
G
C
A
G
C
T
C
A
T
C
G
A
A
A
C
A
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G
C
C
C
T
A
A
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A
A
G
C
C
A
T
G
T
G
G
G
A
G
A
T
G
G
A
T
G
T
0.011742
0.007828
0.021526
0.011742
0.050881
0.041096
0.011742
0.021526
0.039139
0.037182
0.046967
0.005871
0.02544
0.046967
0.013699
0.054795
0.062622
0.066536
0.064579
0.023483
0.013699
0.013699
0.009785
0.048924
0.021526
0.039139
0.027397
0.046967
0.048924
0.023483
0.007828
0.033268
1
2,523
C
A
G
C
C
A
C
A
G
C
A
T
C
A
G
G
T
A
C
T
C
G
G
A
C
T
G
C
A
G
C
T
C
A
T
C
G
A
A
A
C
A
G
G
C
C
C
T
A
A
A
G
A
A
G
C
C
A
T
G
T
G
G
G
A
T
0.011742
0.007828
0.02544
0.009785
0.050881
0.041096
0.011742
0.021526
0.041096
0.039139
0.046967
0.005871
0.02544
0.04501
0.011742
0.054795
0.062622
0.064579
0.064579
0.023483
0.013699
0.013699
0.009785
0.048924
0.023483
0.039139
0.02544
0.046967
0.048924
0.023483
0.007828
0.033268
1
2,524
A
G
T
A
C
C
T
G
A
T
G
C
T
G
T
G
G
C
T
G
G
T
C
C
T
G
G
A
C
T
A
C
T
C
G
G
C
A
G
A
T
G
T
C
C
T
G
T
A
T
G
T
C
T
T
G
G
A
T
G
T
G
C
T
T
C
0.009785
0.007828
0.023483
0.007828
0.054795
0.043053
0.015656
0.019569
0.033268
0.037182
0.054795
0.005871
0.023483
0.04501
0.009785
0.056751
0.064579
0.064579
0.062622
0.023483
0.013699
0.013699
0.011742
0.043053
0.021526
0.043053
0.027397
0.046967
0.052838
0.02544
0.007828
0.029354
1
2,525
T
C
C
T
G
T
A
T
G
T
C
T
T
G
G
A
T
G
T
G
C
T
T
G
T
A
C
G
A
G
C
T
C
G
G
A
C
A
G
G
T
G
A
G
T
G
T
G
C
C
C
C
A
G
G
C
C
T
G
G
G
G
A
G
G
T
0.005871
0.009785
0.02544
0.007828
0.052838
0.04501
0.015656
0.017613
0.027397
0.043053
0.056751
0.007828
0.019569
0.043053
0.015656
0.054795
0.062622
0.066536
0.062622
0.023483
0.013699
0.013699
0.013699
0.043053
0.017613
0.039139
0.029354
0.048924
0.052838
0.027397
0.009785
0.027397
1
2,526
T
C
G
T
C
T
T
G
T
A
A
T
G
C
T
G
C
C
A
C
A
G
C
C
T
G
T
T
G
G
T
A
T
C
A
C
T
G
A
C
C
A
T
T
A
A
G
C
C
T
T
G
C
T
C
G
A
G
A
A
A
A
C
C
T
A
0.064579
0.033268
0.039139
0.043053
0.043053
0.041096
0.005871
0.033268
0.041096
0.019569
0.033268
0.041096
0.02544
0.043053
0.043053
0.031311
0.039139
0.039139
0.019569
0.011742
0.007828
0.005871
0.027397
0.021526
0.04501
0.02544
0.027397
0.021526
0.021526
0.033268
0.027397
0.04501
1
2,527
A
G
A
A
T
T
C
A
A
A
G
A
G
C
C
G
G
G
A
A
A
A
C
T
T
C
A
G
T
A
G
G
C
G
G
T
T
G
A
A
C
C
T
C
A
C
T
T
C
T
G
G
G
T
A
G
T
T
T
G
T
G
C
C
C
T
0.046967
0.029354
0.04501
0.027397
0.041096
0.046967
0.005871
0.037182
0.043053
0.021526
0.035225
0.013699
0.021526
0.043053
0.048924
0.027397
0.046967
0.058708
0.029354
0.011742
0.007828
0.009785
0.017613
0.029354
0.035225
0.037182
0.027397
0.027397
0.033268
0.037182
0.017613
0.039139
1
2,528
T
T
G
T
C
T
C
T
G
T
G
C
G
G
T
C
A
A
A
G
A
A
T
T
C
A
A
A
G
A
G
C
C
G
G
G
A
A
A
A
C
T
T
C
A
G
T
A
G
G
C
G
G
T
T
G
A
A
C
C
T
C
A
C
T
T
0.046967
0.029354
0.046967
0.029354
0.037182
0.052838
0.003914
0.035225
0.043053
0.019569
0.037182
0.011742
0.021526
0.043053
0.050881
0.027397
0.043053
0.064579
0.031311
0.009785
0.007828
0.009785
0.015656
0.031311
0.035225
0.037182
0.023483
0.02544
0.033268
0.035225
0.019569
0.041096
1
2,529
T
T
G
T
C
T
C
T
G
T
G
C
G
G
T
C
A
A
A
G
A
A
T
T
C
A
A
A
G
A
G
C
C
G
G
G
A
A
A
A
C
T
T
C
A
G
T
A
G
G
C
G
G
T
T
G
A
A
C
C
T
C
A
C
T
G
0.046967
0.029354
0.046967
0.029354
0.037182
0.052838
0.003914
0.035225
0.043053
0.019569
0.037182
0.011742
0.021526
0.043053
0.050881
0.027397
0.043053
0.064579
0.031311
0.009785
0.007828
0.009785
0.015656
0.031311
0.035225
0.037182
0.023483
0.02544
0.033268
0.035225
0.019569
0.041096
1
2,530
G
T
T
T
T
C
C
C
G
G
C
T
C
T
T
T
G
A
A
T
T
C
T
T
T
G
A
C
C
G
C
A
C
A
G
A
G
A
C
A
A
G
G
A
C
C
A
A
C
T
A
C
C
C
C
A
A
T
A
T
G
T
T
C
A
G
0.041096
0.027397
0.046967
0.027397
0.033268
0.054795
0.005871
0.033268
0.04501
0.019569
0.035225
0.007828
0.023483
0.043053
0.048924
0.031311
0.043053
0.066536
0.043053
0.011742
0.007828
0.009785
0.015656
0.031311
0.035225
0.039139
0.023483
0.02544
0.033268
0.029354
0.017613
0.043053
1
2,531
G
T
T
T
G
G
G
T
A
G
A
C
C
C
A
G
G
A
G
T
C
T
G
T
C
C
C
A
A
A
A
C
C
A
A
T
G
A
A
C
T
T
G
G
A
A
A
T
G
G
C
A
A
A
G
T
A
G
A
T
G
C
A
G
G
A
0.033268
0.027397
0.041096
0.031311
0.033268
0.052838
0.009785
0.035225
0.048924
0.011742
0.029354
0.009785
0.02544
0.043053
0.050881
0.039139
0.035225
0.072407
0.048924
0.013699
0.009785
0.009785
0.013699
0.035225
0.039139
0.035225
0.023483
0.02544
0.037182
0.029354
0.009785
0.039139
1
2,532
C
A
T
T
T
C
C
A
A
G
T
T
C
A
T
T
G
G
T
T
T
T
G
G
G
A
C
A
G
A
C
T
C
C
T
G
G
G
T
C
T
A
C
C
C
A
A
A
C
A
T
C
T
C
A
A
T
C
C
C
A
G
A
G
C
T
0.033268
0.02544
0.041096
0.035225
0.033268
0.050881
0.005871
0.033268
0.048924
0.011742
0.031311
0.009785
0.029354
0.043053
0.052838
0.037182
0.035225
0.072407
0.048924
0.013699
0.007828
0.007828
0.013699
0.035225
0.041096
0.031311
0.021526
0.029354
0.039139
0.029354
0.009785
0.041096
1
2,533
T
T
G
G
G
A
C
A
G
A
C
T
C
C
T
G
G
G
T
C
T
A
C
C
C
A
A
A
C
A
T
C
T
C
A
A
T
C
C
C
A
G
A
G
C
A
T
G
G
G
C
G
C
C
T
C
T
C
C
A
G
G
A
A
G
C
0.033268
0.02544
0.041096
0.035225
0.029354
0.050881
0.005871
0.037182
0.048924
0.009785
0.031311
0.009785
0.029354
0.046967
0.050881
0.035225
0.037182
0.072407
0.046967
0.013699
0.007828
0.007828
0.013699
0.035225
0.039139
0.029354
0.027397
0.029354
0.035225
0.033268
0.009785
0.041096
1
2,534
T
C
T
A
C
C
C
A
A
A
C
A
T
C
T
C
A
A
T
C
C
C
A
G
A
G
C
A
T
G
G
G
C
G
C
C
T
C
T
C
C
A
G
G
A
A
G
T
A
C
A
T
T
T
A
C
A
G
T
C
T
C
T
A
C
T
0.033268
0.02544
0.04501
0.035225
0.029354
0.048924
0.005871
0.037182
0.048924
0.009785
0.031311
0.009785
0.029354
0.046967
0.054795
0.035225
0.033268
0.068493
0.043053
0.013699
0.005871
0.009785
0.013699
0.035225
0.041096
0.027397
0.029354
0.029354
0.037182
0.033268
0.009785
0.043053
1
2,535
T
G
A
C
C
C
T
T
A
C
C
A
C
C
A
T
T
G
G
T
G
A
G
A
C
C
C
C
A
C
C
C
C
C
C
G
T
G
A
A
A
G
A
T
G
A
G
G
A
G
T
A
T
C
T
C
T
T
T
G
T
G
G
T
C
T
0.02544
0.023483
0.041096
0.033268
0.031311
0.052838
0.009785
0.031311
0.052838
0.007828
0.031311
0.011742
0.033268
0.048924
0.056751
0.037182
0.031311
0.074364
0.041096
0.015656
0.005871
0.011742
0.011742
0.037182
0.035225
0.035225
0.029354
0.02544
0.043053
0.029354
0.005871
0.039139
1
2,536
T
G
A
T
T
T
T
T
G
C
C
A
C
C
A
T
T
G
T
G
G
G
C
A
A
T
G
T
G
G
G
C
T
C
C
A
T
G
A
T
C
T
C
G
A
A
T
A
T
G
A
A
T
G
C
C
T
C
A
C
G
G
G
C
A
C
0.023483
0.021526
0.04501
0.02544
0.02544
0.048924
0.015656
0.027397
0.052838
0.017613
0.037182
0.007828
0.033268
0.043053
0.048924
0.039139
0.041096
0.072407
0.037182
0.013699
0.009785
0.015656
0.009785
0.041096
0.037182
0.033268
0.033268
0.031311
0.043053
0.023483
0.005871
0.039139
1
2,537
T
G
G
G
C
T
C
C
A
T
G
A
T
C
T
C
G
A
A
T
A
T
G
A
A
T
G
C
C
T
C
A
C
G
G
G
C
A
G
A
G
T
T
C
C
A
G
G
C
C
A
A
G
A
T
T
G
A
T
T
C
C
A
T
C
T
0.019569
0.021526
0.043053
0.021526
0.027397
0.052838
0.015656
0.02544
0.050881
0.02544
0.039139
0.007828
0.031311
0.037182
0.046967
0.043053
0.04501
0.074364
0.039139
0.013699
0.009785
0.015656
0.007828
0.04501
0.035225
0.033268
0.029354
0.031311
0.043053
0.021526
0.005871
0.041096
1
2,538
C
C
T
C
A
C
G
G
G
C
A
G
A
G
T
T
C
C
A
G
G
C
C
A
A
G
A
T
T
G
A
T
T
C
C
A
T
C
A
A
G
C
A
G
T
A
C
A
T
G
C
A
G
T
T
C
C
G
C
A
A
G
G
T
C
C
0.015656
0.019569
0.043053
0.019569
0.029354
0.052838
0.015656
0.023483
0.048924
0.031311
0.039139
0.007828
0.031311
0.035225
0.041096
0.048924
0.050881
0.07045
0.039139
0.013699
0.011742
0.017613
0.007828
0.04501
0.035225
0.031311
0.033268
0.031311
0.039139
0.021526
0.005871
0.043053
1
2,539
A
G
A
T
T
G
A
T
T
C
C
A
T
C
A
A
G
C
A
G
T
A
C
A
T
G
C
A
G
T
T
C
C
G
C
A
A
G
G
T
C
A
C
C
A
A
G
G
A
C
T
T
G
G
A
G
A
C
G
C
G
G
G
T
T
T
0.013699
0.017613
0.04501
0.021526
0.027397
0.048924
0.015656
0.023483
0.048924
0.033268
0.039139
0.013699
0.033268
0.033268
0.039139
0.048924
0.052838
0.068493
0.041096
0.013699
0.011742
0.017613
0.005871
0.041096
0.037182
0.029354
0.037182
0.033268
0.039139
0.019569
0.007828
0.041096
1
2,540
A
G
T
T
C
C
G
C
A
A
G
G
T
C
A
C
C
A
A
G
G
A
C
T
T
G
G
A
G
A
C
G
C
G
G
G
T
T
A
T
C
C
G
G
T
G
G
T
T
T
G
A
C
T
A
C
C
T
G
T
G
G
G
C
C
T
0.013699
0.017613
0.048924
0.021526
0.031311
0.048924
0.015656
0.023483
0.048924
0.031311
0.039139
0.017613
0.035225
0.033268
0.041096
0.048924
0.048924
0.064579
0.041096
0.013699
0.011742
0.013699
0.005871
0.039139
0.039139
0.029354
0.035225
0.029354
0.039139
0.023483
0.007828
0.041096
1
2,541
A
G
G
T
C
A
C
C
A
A
G
G
A
C
T
T
G
G
A
G
A
C
G
C
G
G
G
T
T
A
T
C
C
G
G
T
G
G
T
T
T
G
A
C
T
A
C
C
T
G
T
G
G
G
C
C
A
A
C
A
A
G
A
A
G
T
0.011742
0.019569
0.046967
0.019569
0.029354
0.048924
0.017613
0.021526
0.048924
0.031311
0.039139
0.017613
0.039139
0.033268
0.043053
0.048924
0.048924
0.064579
0.041096
0.013699
0.013699
0.013699
0.005871
0.039139
0.037182
0.029354
0.035225
0.029354
0.039139
0.019569
0.007828
0.04501
1
2,542
C
C
G
T
C
T
T
C
T
T
G
T
T
G
G
C
C
C
A
C
A
G
G
T
A
G
T
C
A
A
A
C
C
A
C
C
G
G
A
T
A
A
C
C
C
G
C
G
T
C
T
C
C
A
A
G
T
C
C
T
T
G
G
T
G
G
0.011742
0.019569
0.046967
0.019569
0.027397
0.048924
0.017613
0.021526
0.048924
0.031311
0.041096
0.017613
0.039139
0.033268
0.043053
0.048924
0.046967
0.064579
0.043053
0.013699
0.013699
0.013699
0.005871
0.041096
0.037182
0.029354
0.035225
0.031311
0.039139
0.017613
0.005871
0.04501
1
2,543
C
T
T
C
T
T
C
A
G
C
G
T
G
T
C
C
A
G
G
T
G
C
A
C
G
T
T
G
A
T
G
G
C
G
A
T
C
T
C
A
G
C
C
T
T
C
A
G
C
T
T
G
T
C
T
G
G
G
A
G
G
C
T
C
T
T
0.007828
0.021526
0.043053
0.019569
0.02544
0.039139
0.017613
0.019569
0.041096
0.04501
0.037182
0.015656
0.04501
0.037182
0.039139
0.04501
0.058708
0.064579
0.039139
0.015656
0.017613
0.015656
0.003914
0.035225
0.043053
0.023483
0.041096
0.039139
0.039139
0.011742
0.003914
0.048924
1
2,544
C
C
T
C
G
T
T
G
A
T
G
A
T
G
T
A
C
A
T
C
T
C
C
T
T
C
C
C
A
A
T
A
T
C
T
C
C
C
T
T
C
T
T
G
C
A
G
A
T
A
T
A
A
T
C
C
C
C
A
G
G
G
C
T
G
A
0.003914
0.023483
0.04501
0.007828
0.023483
0.039139
0.019569
0.017613
0.039139
0.048924
0.048924
0.011742
0.041096
0.029354
0.035225
0.035225
0.060665
0.054795
0.046967
0.023483
0.021526
0.017613
0.005871
0.04501
0.037182
0.029354
0.035225
0.043053
0.04501
0.013699
0.003914
0.046967
1
2,545
G
A
A
G
G
A
G
A
T
G
T
A
C
A
T
C
A
T
C
A
A
C
G
A
G
G
G
C
A
A
G
C
T
G
G
C
C
G
T
G
G
T
G
G
C
T
G
A
T
G
A
T
G
G
G
G
T
C
A
C
C
C
A
G
T
G
0.005871
0.021526
0.04501
0.007828
0.02544
0.033268
0.019569
0.015656
0.043053
0.048924
0.054795
0.009785
0.048924
0.031311
0.031311
0.031311
0.066536
0.048924
0.04501
0.019569
0.021526
0.013699
0.005871
0.04501
0.041096
0.027397
0.037182
0.04501
0.04501
0.013699
0.001957
0.048924
1
2,546
C
A
C
G
A
A
C
T
G
G
G
T
G
A
C
C
C
C
A
T
C
A
T
C
A
G
C
C
A
C
C
A
C
G
G
C
C
A
G
C
T
T
G
C
C
C
T
C
G
T
T
G
A
T
G
A
T
G
T
A
C
A
T
C
T
T
0.005871
0.021526
0.04501
0.007828
0.02544
0.031311
0.019569
0.013699
0.043053
0.048924
0.054795
0.009785
0.050881
0.033268
0.031311
0.031311
0.066536
0.048924
0.04501
0.019569
0.02544
0.013699
0.003914
0.04501
0.041096
0.02544
0.037182
0.04501
0.04501
0.011742
0.001957
0.050881
1