Datasets:
TabBioMed
/
vep_pathogenic_coding

Dataset card Data Studio Files
xet
 Community
row_idx
int64
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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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C
A
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A
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C
T
G
C
A
G
C
T
G
A
G
C
T
T
C
A
A
G
A
A
C
A
0
0.017613
0.039139
0
0.019569
0.029354
0.031311
0.017613
0.021526
0.062622
0.037182
0.001957
0.017613
0.011742
0.037182
0.046967
0.050881
0.041096
0.041096
0.054795
0.037182
0.091977
0.003914
0.04501
0.021526
0.031311
0.058708
0.072407
0.029354
0.001957
0
0.027397
1
2,564
G
C
G
G
C
G
T
C
A
T
G
C
G
C
T
T
C
T
C
C
T
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G
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A
T
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C
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A
C
C
C
G
C
A
C
C
A
C
C
T
C
C
T
T
C
T
C
G
C
0.003914
0.011742
0.037182
0.001957
0.015656
0.02544
0.023483
0.011742
0.029354
0.054795
0.039139
0.001957
0.017613
0.009785
0.029354
0.035225
0.048924
0.029354
0.033268
0.086106
0.031311
0.117417
0.003914
0.04501
0.019569
0.027397
0.052838
0.103718
0.02544
0.001957
0
0.02544
1
2,565
T
C
A
T
G
G
T
A
A
A
T
C
C
A
C
C
A
A
C
C
A
A
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A
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C
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A
A
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A
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C
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G
G
C
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A
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C
T
A
T
G
A
T
G
G
C
T
T
C
G
C
T
G
C
G
C
C
0.074364
0.031311
0.037182
0.048924
0.029354
0.02544
0.009785
0.031311
0.037182
0.035225
0.023483
0.050881
0.029354
0.043053
0.037182
0.027397
0.046967
0.052838
0.009785
0.007828
0.005871
0.015656
0.027397
0.015656
0.043053
0.017613
0.037182
0.029354
0.027397
0.019569
0.037182
0.035225
1
2,566
C
A
T
T
T
T
G
T
C
T
G
A
A
G
G
A
A
A
G
C
T
G
G
T
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A
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T
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C
C
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A
A
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G
A
A
C
T
T
G
C
T
G
A
C
A
A
G
A
T
G
G
A
A
T
0.04501
0.04501
0.041096
0.054795
0.056751
0.02544
0.003914
0.02544
0.058708
0.027397
0.015656
0.07045
0.035225
0.048924
0.046967
0.007828
0.062622
0.035225
0.011742
0.001957
0.001957
0
0.015656
0.007828
0.050881
0.023483
0.041096
0.005871
0.021526
0.035225
0.043053
0.033268
1
2,567
C
T
G
T
G
G
A
G
T
C
C
T
T
G
T
G
T
G
C
A
G
A
C
A
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A
C
T
G
G
A
G
T
G
G
G
C
G
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G
G
G
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G
T
G
C
C
A
C
C
T
G
C
C
T
C
C
C
A
G
C
C
A
G
0.033268
0.017613
0.039139
0.017613
0.039139
0.015656
0.017613
0.023483
0.037182
0.052838
0.04501
0.013699
0.027397
0.039139
0.041096
0.039139
0.054795
0.046967
0.027397
0.021526
0.015656
0.011742
0.013699
0.050881
0.023483
0.02544
0.050881
0.060665
0.037182
0.013699
0.009785
0.037182
1
2,568
C
C
A
G
T
T
T
T
G
T
G
A
G
T
A
G
C
T
C
A
G
G
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A
T
G
C
T
G
T
A
G
C
C
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C
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G
T
G
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T
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A
T
G
C
G
G
T
C
A
A
A
G
A
G
T
T
G
C
A
T
G
G
0.029354
0.019569
0.033268
0.015656
0.046967
0.019569
0.017613
0.027397
0.035225
0.054795
0.039139
0.009785
0.021526
0.039139
0.04501
0.048924
0.058708
0.048924
0.029354
0.019569
0.013699
0.011742
0.015656
0.048924
0.019569
0.029354
0.054795
0.058708
0.029354
0.013699
0.003914
0.041096
1
2,569
C
C
A
G
T
T
T
T
G
T
G
A
G
T
A
G
C
T
C
A
G
G
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A
T
G
C
T
G
T
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G
C
C
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A
T
G
C
G
G
T
C
A
A
A
G
A
G
T
T
G
C
A
T
G
T
0.029354
0.019569
0.033268
0.015656
0.046967
0.019569
0.017613
0.027397
0.035225
0.054795
0.039139
0.009785
0.021526
0.039139
0.04501
0.048924
0.058708
0.048924
0.029354
0.019569
0.013699
0.011742
0.015656
0.048924
0.019569
0.029354
0.054795
0.058708
0.029354
0.013699
0.003914
0.041096
1
2,570
A
G
A
C
G
G
C
A
T
G
C
A
A
C
T
C
T
T
T
G
A
C
C
G
C
A
T
C
A
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C
A
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C
A
G
G
C
T
A
C
A
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C
A
T
C
C
C
T
G
A
G
C
T
A
C
T
C
A
C
A
A
T
0.031311
0.019569
0.031311
0.021526
0.046967
0.019569
0.017613
0.027397
0.035225
0.054795
0.037182
0.009785
0.021526
0.037182
0.04501
0.048924
0.058708
0.048924
0.029354
0.019569
0.013699
0.011742
0.015656
0.048924
0.019569
0.029354
0.052838
0.056751
0.029354
0.013699
0.005871
0.041096
1
2,571
T
G
T
C
A
T
G
C
C
C
C
C
A
A
T
C
T
C
A
T
C
C
C
T
C
T
T
C
A
G
G
C
C
G
A
A
G
C
T
C
T
C
G
G
C
G
A
G
G
T
G
G
C
G
C
C
A
C
G
T
T
T
T
C
A
T
0.064579
0.021526
0.02544
0.037182
0.043053
0.017613
0.015656
0.023483
0.031311
0.048924
0.037182
0.013699
0.017613
0.041096
0.039139
0.041096
0.054795
0.043053
0.029354
0.017613
0.013699
0.011742
0.015656
0.043053
0.023483
0.02544
0.052838
0.052838
0.027397
0.011742
0.021526
0.037182
1
2,572
A
A
T
C
T
C
A
T
C
C
C
T
C
T
T
C
A
G
G
C
C
G
A
A
G
C
T
C
T
C
G
G
C
G
A
G
G
T
G
G
C
G
C
C
A
C
G
T
T
T
T
C
A
C
A
A
C
A
G
C
C
T
T
C
T
T
0.07045
0.021526
0.02544
0.039139
0.04501
0.017613
0.013699
0.023483
0.031311
0.046967
0.035225
0.013699
0.017613
0.043053
0.039139
0.041096
0.054795
0.041096
0.027397
0.017613
0.011742
0.011742
0.017613
0.039139
0.023483
0.02544
0.056751
0.048924
0.027397
0.011742
0.023483
0.037182
1
2,573
C
C
C
T
C
T
T
C
A
G
G
C
C
G
A
A
G
C
T
C
T
C
G
G
C
G
A
G
G
T
G
G
C
G
C
C
A
C
G
T
T
T
T
C
A
C
A
A
C
A
G
C
C
T
T
C
T
C
A
G
A
G
T
T
G
T
0.07045
0.023483
0.023483
0.039139
0.04501
0.017613
0.013699
0.02544
0.031311
0.04501
0.033268
0.015656
0.017613
0.04501
0.037182
0.041096
0.054795
0.039139
0.027397
0.017613
0.011742
0.011742
0.017613
0.039139
0.023483
0.02544
0.056751
0.046967
0.02544
0.011742
0.029354
0.037182
1
2,574
C
C
T
T
C
T
C
A
G
A
G
T
T
G
T
A
C
G
T
G
G
A
G
C
T
G
A
G
C
A
T
T
C
G
G
C
T
A
G
T
C
T
T
C
T
C
G
A
G
G
C
A
A
T
C
A
A
A
T
G
G
C
A
G
C
T
0.068493
0.027397
0.02544
0.039139
0.04501
0.019569
0.017613
0.02544
0.037182
0.043053
0.031311
0.015656
0.015656
0.039139
0.039139
0.043053
0.050881
0.037182
0.02544
0.017613
0.013699
0.013699
0.021526
0.041096
0.023483
0.023483
0.054795
0.048924
0.017613
0.013699
0.029354
0.035225
1
2,575
G
C
A
C
A
G
C
T
C
C
G
G
G
G
A
G
C
C
C
T
G
C
T
T
G
T
C
A
G
G
G
G
C
G
G
G
C
T
C
C
T
C
A
T
C
A
C
T
G
T
C
G
A
C
G
C
T
C
C
G
G
C
T
C
A
T
0.021526
0.021526
0.031311
0.011742
0.046967
0.027397
0.009785
0.029354
0.035225
0.058708
0.039139
0.007828
0.017613
0.029354
0.033268
0.04501
0.074364
0.041096
0.056751
0.02544
0.015656
0.011742
0.007828
0.048924
0.023483
0.043053
0.048924
0.043053
0.035225
0.003914
0.007828
0.046967
1
2,576
T
G
G
T
G
T
T
G
G
G
G
G
G
T
G
C
C
A
G
G
A
G
G
C
A
G
G
A
G
T
A
G
C
A
G
A
C
C
A
T
G
C
C
A
T
A
G
A
T
G
T
T
C
C
T
C
G
G
T
C
T
G
T
T
C
T
0.02544
0.021526
0.027397
0.015656
0.054795
0.033268
0.009785
0.033268
0.043053
0.039139
0.056751
0.009785
0.013699
0.027397
0.029354
0.056751
0.072407
0.04501
0.033268
0.015656
0.003914
0.001957
0.023483
0.048924
0.029354
0.037182
0.046967
0.041096
0.043053
0.015656
0.005871
0.039139
1
2,577
G
G
G
C
C
T
G
T
G
C
T
T
A
C
C
C
A
G
G
G
A
G
G
C
A
A
G
G
G
C
C
A
C
A
C
T
C
A
G
C
G
T
C
A
T
T
C
T
C
C
A
T
G
T
C
C
C
C
T
G
G
T
G
T
C
T
0.021526
0.011742
0.031311
0.003914
0.035225
0.031311
0.023483
0.023483
0.02544
0.035225
0.07045
0.007828
0.009785
0.027397
0.021526
0.04501
0.072407
0.058708
0.058708
0.033268
0.007828
0.009785
0.009785
0.039139
0.017613
0.043053
0.054795
0.072407
0.058708
0.013699
0.007828
0.017613
1
2,578
C
T
T
A
C
C
C
A
G
G
G
A
G
G
C
A
A
G
G
G
C
C
A
C
A
C
T
C
A
G
C
G
T
C
A
T
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C
T
C
C
A
T
G
T
C
C
C
C
T
G
G
T
G
T
C
A
G
C
A
C
G
G
T
G
G
0.021526
0.009785
0.031311
0.001957
0.037182
0.029354
0.023483
0.023483
0.029354
0.035225
0.07045
0.007828
0.009785
0.023483
0.021526
0.04501
0.076321
0.056751
0.058708
0.033268
0.007828
0.009785
0.009785
0.041096
0.017613
0.04501
0.054795
0.072407
0.060665
0.013699
0.003914
0.017613
1
2,579
T
C
T
C
C
A
T
G
T
C
C
C
C
T
G
G
T
G
T
C
A
G
C
A
C
G
G
T
G
G
C
C
C
G
G
A
A
G
A
A
G
C
C
C
T
C
A
C
A
G
T
C
T
T
T
G
T
G
A
C
G
C
C
T
G
T
0.023483
0.013699
0.035225
0.001957
0.035225
0.031311
0.023483
0.02544
0.02544
0.035225
0.068493
0.007828
0.007828
0.021526
0.027397
0.041096
0.072407
0.054795
0.058708
0.037182
0.007828
0.009785
0.009785
0.039139
0.021526
0.04501
0.054795
0.068493
0.060665
0.015656
0.001957
0.017613
1
2,580
G
T
G
T
C
A
G
C
A
C
G
G
T
G
G
C
C
C
G
G
A
A
G
A
A
G
C
C
C
T
C
A
C
A
G
T
C
T
T
T
G
T
G
A
C
G
C
C
T
G
C
A
T
A
T
C
T
G
G
T
A
G
C
C
T
G
0.027397
0.017613
0.035225
0.001957
0.033268
0.031311
0.023483
0.027397
0.02544
0.035225
0.068493
0.007828
0.007828
0.021526
0.029354
0.039139
0.07045
0.052838
0.060665
0.033268
0.007828
0.009785
0.011742
0.037182
0.021526
0.043053
0.056751
0.066536
0.058708
0.015656
0.003914
0.017613
1
2,581
T
G
G
C
C
C
G
G
A
A
G
A
A
G
C
C
C
T
C
A
C
A
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T
C
T
T
T
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T
G
A
C
G
C
C
T
G
C
A
T
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T
C
T
G
G
T
A
G
C
C
T
C
C
T
T
T
G
G
A
A
A
A
C
T
0.027397
0.019569
0.035225
0.001957
0.033268
0.033268
0.023483
0.02544
0.02544
0.035225
0.066536
0.007828
0.007828
0.021526
0.029354
0.039139
0.072407
0.054795
0.062622
0.033268
0.007828
0.009785
0.011742
0.035225
0.023483
0.041096
0.056751
0.062622
0.058708
0.015656
0.003914
0.017613
1
2,582
A
G
T
T
T
T
C
C
A
A
A
G
G
A
G
G
C
T
A
C
C
A
G
A
T
A
T
G
C
A
G
G
C
G
T
C
A
C
A
A
A
G
A
C
T
G
T
G
A
G
G
G
C
T
T
C
T
T
C
C
G
G
G
C
C
T
0.027397
0.019569
0.035225
0.001957
0.033268
0.033268
0.023483
0.02544
0.023483
0.037182
0.066536
0.007828
0.007828
0.021526
0.029354
0.039139
0.072407
0.054795
0.062622
0.033268
0.007828
0.009785
0.011742
0.035225
0.023483
0.041096
0.056751
0.062622
0.058708
0.015656
0.003914
0.017613
1
2,583
C
T
T
T
G
G
A
A
A
A
C
T
T
C
T
C
C
G
C
C
G
G
G
C
A
G
G
G
G
A
C
G
C
A
G
C
C
G
T
A
G
T
C
C
T
C
G
T
C
T
T
T
G
G
T
G
C
C
G
T
A
G
C
C
A
T
0.027397
0.019569
0.033268
0.001957
0.029354
0.029354
0.021526
0.027397
0.031311
0.041096
0.064579
0.007828
0.005871
0.023483
0.027397
0.035225
0.072407
0.050881
0.064579
0.029354
0.009785
0.009785
0.011742
0.046967
0.023483
0.037182
0.058708
0.066536
0.050881
0.015656
0.003914
0.021526
1
2,584
T
T
G
G
C
A
G
G
T
G
T
C
T
C
T
G
A
T
G
T
G
C
T
C
A
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C
C
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G
A
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A
A
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C
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C
T
G
C
G
G
T
G
A
G
A
A
C
G
A
G
T
A
C
T
T
0.007828
0.023483
0.023483
0.005871
0.033268
0.04501
0.015656
0.023483
0.027397
0.046967
0.064579
0.009785
0.013699
0.013699
0.035225
0.054795
0.062622
0.048924
0.084149
0.027397
0.005871
0.013699
0.015656
0.060665
0.011742
0.019569
0.046967
0.060665
0.037182
0.019569
0.005871
0.035225
1
2,585
A
A
A
G
A
G
T
G
C
A
G
T
G
G
C
T
G
A
T
A
G
G
C
A
C
G
C
A
T
T
A
C
C
T
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C
C
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C
C
A
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A
A
G
C
T
G
T
G
A
G
A
G
C
G
T
G
G
A
A
G
G
C
C
T
0.084149
0.031311
0.039139
0.035225
0.043053
0.011742
0.011742
0.031311
0.048924
0.027397
0.039139
0.033268
0.04501
0.035225
0.027397
0.035225
0.054795
0.029354
0.017613
0.003914
0.003914
0.003914
0.021526
0.033268
0.046967
0.015656
0.029354
0.02544
0.037182
0.015656
0.031311
0.050881
1
2,586
T
G
A
T
A
T
T
T
C
T
G
A
T
G
A
C
A
A
A
G
A
T
G
A
A
T
G
G
C
A
A
T
C
T
C
T
A
G
A
T
C
A
A
A
A
T
G
A
A
G
A
T
G
C
A
T
T
T
G
A
A
G
C
C
C
A
0.09589
0.027397
0.054795
0.054795
0.04501
0.023483
0.003914
0.029354
0.035225
0.027397
0.031311
0.041096
0.037182
0.046967
0.04501
0.04501
0.027397
0.019569
0.013699
0.001957
0
0.001957
0.02544
0.013699
0.04501
0.011742
0.041096
0.015656
0.013699
0.017613
0.048924
0.058708
1
2,587
T
T
T
G
G
C
C
G
C
T
G
C
C
G
G
C
C
A
G
C
G
T
C
C
T
C
T
G
G
C
C
A
T
G
G
A
C
A
C
C
C
C
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G
A
A
A
A
T
G
T
C
C
T
T
C
A
G
T
A
A
G
T
G
T
G
0.023483
0.031311
0.031311
0.011742
0.011742
0.043053
0.017613
0.013699
0.015656
0.037182
0.04501
0.001957
0.005871
0.011742
0.033268
0.027397
0.046967
0.060665
0.09002
0.078278
0.021526
0.050881
0.005871
0.029354
0.039139
0.021526
0.02544
0.101761
0.039139
0.005871
0.001957
0.019569
1
2,588
C
C
A
G
G
A
T
A
G
C
C
G
A
G
G
A
C
T
C
T
T
A
C
A
T
G
C
A
G
T
T
T
C
G
A
G
C
A
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C
T
A
A
A
T
C
T
C
G
A
T
G
A
A
G
A
A
A
A
T
T
C
C
T
G
T
0.07045
0.031311
0.048924
0.029354
0.027397
0.021526
0
0.039139
0.046967
0.033268
0.039139
0.041096
0.033268
0.033268
0.031311
0.027397
0.04501
0.037182
0.031311
0.009785
0.011742
0.001957
0.023483
0.039139
0.050881
0.017613
0.039139
0.015656
0.048924
0.011742
0.029354
0.033268
1
2,589
T
A
G
G
T
T
G
C
G
A
G
A
T
G
A
C
A
T
G
A
C
T
G
T
C
T
G
T
G
T
T
G
C
G
G
A
C
T
T
C
G
G
C
C
T
C
T
C
T
A
A
G
A
A
G
A
T
T
T
A
C
A
G
T
G
T
0.054795
0.017613
0.046967
0.035225
0.048924
0.031311
0.005871
0.027397
0.058708
0.039139
0.029354
0.019569
0.02544
0.039139
0.050881
0.033268
0.054795
0.033268
0.011742
0.009785
0.009785
0.013699
0.009785
0.043053
0.017613
0.037182
0.054795
0.029354
0.011742
0.02544
0.031311
0.043053
1
2,590
A
G
G
T
G
G
G
G
C
G
G
T
C
T
A
A
G
G
G
A
T
C
G
G
T
T
C
T
C
C
A
G
C
A
A
G
A
G
T
A
C
A
T
T
A
T
T
T
C
A
T
A
C
C
T
G
A
A
A
G
T
T
A
A
A
T
0.080235
0.029354
0.039139
0.043053
0.035225
0.021526
0.011742
0.035225
0.043053
0.029354
0.029354
0.037182
0.021526
0.037182
0.037182
0.031311
0.046967
0.041096
0.023483
0.007828
0.007828
0.007828
0.017613
0.033268
0.037182
0.023483
0.039139
0.029354
0.027397
0.021526
0.037182
0.037182
1
2,591
T
G
T
A
C
T
C
T
T
G
C
T
G
G
A
G
A
A
C
C
G
A
T
C
C
C
T
T
A
G
A
C
C
G
C
C
C
C
A
C
C
T
T
T
T
C
A
G
T
A
T
T
G
A
G
G
C
T
G
C
A
G
C
T
A
T
0.082192
0.029354
0.039139
0.043053
0.033268
0.02544
0.013699
0.033268
0.041096
0.029354
0.033268
0.031311
0.021526
0.037182
0.039139
0.027397
0.046967
0.039139
0.023483
0.009785
0.007828
0.007828
0.017613
0.033268
0.037182
0.02544
0.037182
0.027397
0.027397
0.023483
0.035225
0.041096
1
2,592
A
A
C
T
T
C
A
T
C
C
C
T
T
T
C
T
C
T
G
A
T
C
A
C
A
A
C
C
A
G
A
G
T
C
C
A
C
G
G
A
A
C
A
T
G
T
A
C
C
A
A
T
G
C
C
A
G
A
T
G
G
G
T
A
A
A
0.07045
0.039139
0.041096
0.033268
0.054795
0.021526
0.001957
0.046967
0.04501
0.021526
0.021526
0.023483
0.039139
0.052838
0.041096
0.037182
0.048924
0.046967
0.013699
0.001957
0.001957
0.001957
0.011742
0.033268
0.037182
0.017613
0.031311
0.015656
0.033268
0.031311
0.035225
0.046967
1
2,593
T
C
T
T
C
A
T
A
G
G
A
G
T
G
G
T
T
T
A
T
T
A
T
C
A
G
C
G
C
T
T
A
C
G
C
C
A
T
A
T
G
G
T
C
T
C
A
G
A
C
A
A
A
T
T
T
C
A
A
G
T
A
A
G
G
A
0.033268
0.027397
0.041096
0.023483
0.031311
0.033268
0.005871
0.031311
0.056751
0.035225
0.023483
0.02544
0.027397
0.060665
0.027397
0.031311
0.037182
0.060665
0.033268
0.021526
0.009785
0.013699
0.021526
0.046967
0.041096
0.023483
0.027397
0.033268
0.037182
0.019569
0.023483
0.035225
1
2,594
T
C
T
T
C
A
T
A
G
G
A
G
T
G
G
T
T
T
A
T
T
A
T
C
A
G
C
G
C
T
T
A
C
G
C
C
A
T
A
T
G
G
T
C
T
C
A
G
A
C
A
A
A
T
T
T
C
A
A
G
T
A
A
G
G
T
0.033268
0.027397
0.041096
0.023483
0.031311
0.033268
0.005871
0.031311
0.056751
0.035225
0.023483
0.02544
0.027397
0.060665
0.027397
0.031311
0.037182
0.060665
0.033268
0.021526
0.009785
0.013699
0.021526
0.046967
0.041096
0.023483
0.027397
0.033268
0.037182
0.019569
0.023483
0.035225
1
2,595
G
C
G
T
T
T
G
A
A
G
A
A
A
A
A
C
T
G
T
C
A
C
T
G
A
A
G
A
G
T
C
A
T
G
G
T
G
G
G
G
C
C
C
G
G
G
C
C
T
A
C
C
G
C
T
G
C
T
G
C
C
G
C
T
G
C
0.021526
0.029354
0.019569
0.009785
0.015656
0.031311
0.041096
0.019569
0.021526
0.029354
0.050881
0.005871
0.005871
0.009785
0.02544
0.027397
0.04501
0.033268
0.074364
0.068493
0.019569
0.076321
0.015656
0.041096
0.029354
0.035225
0.031311
0.078278
0.043053
0.013699
0.003914
0.027397
1
2,596
G
C
T
G
G
A
G
T
C
G
G
C
G
G
C
T
C
A
C
C
C
C
G
G
A
T
G
G
T
T
C
A
T
C
T
G
C
A
C
C
T
C
C
T
G
C
A
A
T
T
G
T
A
A
T
G
A
G
C
C
T
G
T
T
G
C
0.074364
0.033268
0.033268
0.046967
0.039139
0.023483
0.003914
0.015656
0.031311
0.039139
0.058708
0.011742
0.02544
0.041096
0.033268
0.031311
0.048924
0.029354
0.031311
0.011742
0.005871
0.009785
0.015656
0.046967
0.048924
0.009785
0.031311
0.033268
0.041096
0.007828
0.031311
0.054795
1
2,597
G
A
A
G
G
T
G
C
T
T
T
A
T
C
T
G
C
A
T
A
A
T
A
A
C
C
A
G
C
T
T
C
T
A
G
C
T
G
G
A
G
G
G
C
T
G
C
A
T
G
C
A
G
G
G
A
A
G
G
T
C
A
T
T
A
C
0.027397
0.013699
0.04501
0.021526
0.035225
0.027397
0
0.02544
0.052838
0.043053
0.066536
0.021526
0.017613
0.041096
0.021526
0.031311
0.066536
0.039139
0.054795
0.001957
0.001957
0
0.029354
0.048924
0.037182
0.02544
0.046967
0.043053
0.037182
0.017613
0.021526
0.037182
1
2,598
G
T
C
G
G
C
T
G
C
C
T
A
C
C
C
G
G
G
C
T
G
G
T
T
C
C
T
G
T
G
C
A
C
G
G
T
G
C
C
T
G
A
A
G
C
C
G
A
T
C
A
G
C
C
T
G
T
C
A
G
A
C
T
C
A
G
0.005871
0.013699
0.031311
0.009785
0.021526
0.039139
0.009785
0.027397
0.043053
0.052838
0.056751
0.001957
0.021526
0.021526
0.017613
0.048924
0.074364
0.058708
0.074364
0.02544
0.011742
0.003914
0.019569
0.054795
0.033268
0.029354
0.043053
0.052838
0.048924
0.005871
0.003914
0.037182
1
2,599
A
T
G
G
C
C
T
T
T
C
T
T
C
T
C
T
T
C
A
T
C
A
C
A
G
A
A
T
C
A
T
C
C
G
G
A
C
C
A
A
A
G
T
G
C
A
G
C
A
A
C
C
A
T
T
C
A
A
C
C
T
C
C
C
T
T
0.02544
0.019569
0.033268
0.009785
0.066536
0.033268
0.007828
0.043053
0.046967
0.023483
0.041096
0.015656
0.015656
0.04501
0.031311
0.064579
0.054795
0.046967
0.035225
0.011742
0.007828
0.011742
0.011742
0.052838
0.027397
0.041096
0.035225
0.031311
0.035225
0.023483
0.003914
0.046967
1
2,600
C
C
G
C
G
T
C
A
G
C
C
A
T
G
G
C
T
G
C
G
T
C
A
G
C
A
A
G
A
T
C
C
T
T
G
G
C
A
G
G
T
A
A
G
C
A
C
G
A
A
A
T
T
C
A
C
C
G
C
A
G
G
C
C
G
G
0.031311
0.013699
0.039139
0.023483
0.035225
0.035225
0.009785
0.015656
0.041096
0.046967
0.062622
0.011742
0.017613
0.021526
0.021526
0.033268
0.068493
0.056751
0.056751
0.015656
0.007828
0.021526
0.021526
0.037182
0.041096
0.031311
0.027397
0.048924
0.050881
0.015656
0.013699
0.02544
1
2,601
T
T
C
G
T
G
C
T
T
A
C
C
T
G
C
C
A
A
G
G
A
T
C
T
T
G
C
T
G
A
C
G
C
A
G
C
C
A
T
G
G
C
T
G
A
C
G
C
G
G
A
G
C
T
G
G
C
G
A
G
A
G
A
T
G
T
0.031311
0.015656
0.037182
0.023483
0.037182
0.037182
0.009785
0.017613
0.037182
0.046967
0.058708
0.011742
0.017613
0.02544
0.023483
0.035225
0.07045
0.058708
0.052838
0.015656
0.007828
0.021526
0.021526
0.031311
0.037182
0.035225
0.027397
0.048924
0.046967
0.015656
0.013699
0.029354
1
2,602
C
C
T
G
C
C
A
A
G
G
A
T
C
T
T
G
C
T
G
A
C
G
C
A
G
C
C
A
T
G
G
C
T
G
A
C
G
C
G
G
A
G
C
T
G
G
C
G
A
G
A
G
A
T
G
T
C
G
C
A
G
G
G
C
C
C
0.029354
0.013699
0.033268
0.02544
0.037182
0.037182
0.011742
0.015656
0.035225
0.046967
0.058708
0.011742
0.019569
0.02544
0.023483
0.037182
0.07045
0.060665
0.054795
0.015656
0.007828
0.021526
0.019569
0.031311
0.037182
0.035225
0.027397
0.048924
0.048924
0.015656
0.011742
0.031311
1
2,603
G
G
C
C
C
A
C
C
A
G
G
G
T
G
T
A
A
G
G
C
C
C
T
G
C
G
A
C
A
T
C
T
C
T
C
G
C
C
A
G
C
T
C
C
G
C
G
T
C
A
G
C
C
A
T
G
G
C
T
G
C
G
T
C
A
T
0.02544
0.013699
0.031311
0.023483
0.037182
0.037182
0.011742
0.015656
0.033268
0.046967
0.060665
0.009785
0.017613
0.023483
0.021526
0.039139
0.074364
0.062622
0.058708
0.017613
0.007828
0.021526
0.019569
0.031311
0.035225
0.033268
0.027397
0.060665
0.04501
0.015656
0.009785
0.031311
1
2,604
G
C
T
G
G
C
G
A
G
A
G
A
T
G
T
C
G
C
A
G
G
G
C
C
T
T
A
C
A
C
C
C
T
G
G
T
G
G
G
C
C
A
G
G
T
C
T
A
C
G
A
T
G
C
G
C
T
G
G
C
G
G
A
C
C
G
0.019569
0.013699
0.02544
0.023483
0.035225
0.039139
0.011742
0.015656
0.033268
0.046967
0.060665
0.009785
0.017613
0.023483
0.019569
0.041096
0.076321
0.064579
0.068493
0.017613
0.007828
0.021526
0.019569
0.033268
0.033268
0.033268
0.029354
0.058708
0.04501
0.013699
0.009785
0.031311
1
2,605
C
A
G
A
C
C
T
C
T
G
C
C
G
G
A
A
G
T
G
G
T
C
C
G
C
C
A
G
C
G
C
A
T
C
G
T
A
G
A
C
C
T
G
G
C
C
C
A
C
C
A
G
G
G
T
G
T
A
A
G
G
C
C
C
T
A
0.013699
0.013699
0.027397
0.021526
0.035225
0.037182
0.011742
0.015656
0.033268
0.046967
0.060665
0.007828
0.019569
0.02544
0.021526
0.041096
0.076321
0.064579
0.068493
0.017613
0.007828
0.021526
0.015656
0.037182
0.031311
0.033268
0.031311
0.058708
0.046967
0.013699
0.009785
0.033268
1
2,606
C
A
C
C
C
T
G
G
T
G
G
G
C
C
A
G
G
T
C
T
A
C
G
A
T
G
C
G
C
T
G
G
C
G
G
A
C
C
A
C
T
T
C
C
G
G
C
A
G
A
G
G
T
C
T
G
C
C
A
T
T
C
A
C
A
T
0.015656
0.013699
0.027397
0.023483
0.037182
0.039139
0.011742
0.015656
0.031311
0.046967
0.058708
0.007828
0.019569
0.027397
0.023483
0.043053
0.076321
0.064579
0.066536
0.017613
0.007828
0.021526
0.013699
0.035225
0.031311
0.033268
0.033268
0.054795
0.046967
0.011742
0.009785
0.033268
1
2,607
T
T
G
T
G
A
A
T
G
G
C
A
G
A
C
C
T
C
T
G
C
C
G
G
A
A
G
T
G
G
T
C
C
G
C
C
A
G
C
G
C
A
T
C
G
T
A
G
A
C
C
T
G
G
C
C
C
A
C
C
A
G
G
G
T
T
0.015656
0.013699
0.027397
0.023483
0.037182
0.039139
0.011742
0.015656
0.031311
0.046967
0.058708
0.007828
0.019569
0.027397
0.023483
0.043053
0.074364
0.064579
0.066536
0.017613
0.007828
0.021526
0.013699
0.035225
0.031311
0.033268
0.033268
0.054795
0.046967
0.013699
0.009785
0.033268
1
2,608
A
G
G
A
G
T
T
T
G
T
G
T
G
C
C
G
C
T
G
G
C
A
G
G
C
C
T
G
C
A
C
G
C
G
G
G
A
G
C
A
G
A
A
G
C
C
C
T
T
C
A
A
G
G
C
G
C
A
G
T
A
C
A
T
G
G
0.005871
0.013699
0.021526
0.003914
0.048924
0.046967
0.013699
0.011742
0.027397
0.039139
0.058708
0.007828
0.013699
0.029354
0.017613
0.07045
0.076321
0.060665
0.086106
0.031311
0.007828
0.019569
0.005871
0.033268
0.017613
0.027397
0.062622
0.07045
0.035225
0.009785
0.003914
0.021526
1
2,609
T
T
G
A
A
G
G
G
A
C
T
C
G
T
A
G
T
G
G
T
G
C
C
G
G
G
C
A
C
T
G
T
C
G
T
A
G
T
C
C
A
C
C
A
G
C
T
T
G
C
G
C
C
C
C
C
G
C
T
T
G
G
C
A
A
T
0.013699
0.011742
0.029354
0.005871
0.019569
0.043053
0.013699
0.02544
0.023483
0.037182
0.076321
0.001957
0.007828
0.007828
0.02544
0.050881
0.066536
0.062622
0.101761
0.02544
0.011742
0.019569
0.013699
0.052838
0.017613
0.031311
0.043053
0.074364
0.048924
0.007828
0.003914
0.02544
1
2,610
T
G
C
T
C
A
A
A
C
T
G
C
T
C
A
T
C
C
T
T
G
G
T
C
T
C
A
T
C
T
G
C
C
T
T
C
C
C
C
A
G
C
T
T
C
T
G
G
A
G
A
A
C
C
T
G
C
C
G
A
A
G
C
C
A
A
0.031311
0.017613
0.039139
0.023483
0.02544
0.037182
0.005871
0.02544
0.039139
0.050881
0.054795
0.003914
0.017613
0.029354
0.037182
0.041096
0.058708
0.07045
0.060665
0.003914
0.011742
0.001957
0.015656
0.056751
0.033268
0.019569
0.037182
0.046967
0.04501
0.015656
0.009785
0.033268
1
2,611
A
A
C
G
C
T
G
A
C
A
G
C
T
G
C
A
T
A
C
A
A
G
G
A
G
T
A
G
G
C
A
G
T
T
A
G
T
T
T
G
T
A
C
T
C
A
T
G
C
A
C
A
T
G
G
G
T
T
G
G
T
C
G
G
C
G
0.021526
0.027397
0.039139
0.033268
0.043053
0.023483
0.003914
0.035225
0.043053
0.04501
0.031311
0.035225
0.019569
0.048924
0.048924
0.029354
0.062622
0.052838
0.023483
0.005871
0.007828
0.001957
0.013699
0.039139
0.029354
0.027397
0.058708
0.039139
0.029354
0.021526
0.023483
0.035225
1
2,612
C
T
T
C
T
C
T
C
C
A
G
T
T
T
A
C
A
A
A
T
A
T
G
C
C
C
A
A
G
A
C
T
T
C
T
T
G
G
T
G
G
C
T
A
T
T
G
C
A
G
A
G
C
C
A
G
T
G
T
G
C
C
G
A
C
C
0.029354
0.029354
0.046967
0.031311
0.048924
0.021526
0.001957
0.039139
0.050881
0.041096
0.031311
0.037182
0.019569
0.041096
0.048924
0.027397
0.062622
0.046967
0.021526
0.005871
0.005871
0.001957
0.015656
0.037182
0.031311
0.02544
0.052838
0.037182
0.02544
0.02544
0.027397
0.031311
1
2,613
T
A
C
C
A
A
G
A
G
G
A
G
C
T
G
G
T
G
T
G
C
C
G
G
A
A
A
T
T
C
C
C
C
A
G
G
T
G
G
C
C
A
C
G
A
A
C
A
G
C
A
G
G
A
G
G
C
T
T
G
T
G
A
G
C
T
0.003914
0.005871
0.027397
0.013699
0.031311
0.033268
0.009785
0.011742
0.031311
0.058708
0.072407
0.001957
0.013699
0.021526
0.015656
0.050881
0.082192
0.058708
0.078278
0.02544
0.007828
0.015656
0.015656
0.048924
0.029354
0.017613
0.048924
0.084149
0.039139
0.011742
0.001957
0.031311
1
2,614
C
A
A
A
A
C
C
A
G
A
C
T
C
A
G
T
G
T
T
C
T
C
C
A
G
C
A
G
C
G
A
G
C
G
T
G
C
C
C
A
C
C
A
G
G
T
G
C
T
G
C
G
G
A
T
C
C
G
C
A
A
A
C
G
T
T
0.019569
0.013699
0.031311
0.013699
0.017613
0.027397
0.009785
0.019569
0.041096
0.052838
0.076321
0.001957
0.015656
0.027397
0.02544
0.029354
0.060665
0.060665
0.068493
0.009785
0.013699
0.017613
0.011742
0.086106
0.023483
0.027397
0.035225
0.050881
0.068493
0.003914
0.009785
0.029354
1
2,615
G
C
A
A
A
C
G
T
G
C
C
A
A
C
T
C
C
T
T
C
C
T
G
G
A
G
G
A
G
C
T
C
C
G
T
C
A
C
A
G
C
A
G
C
C
T
G
G
A
G
C
G
G
G
A
G
T
G
C
A
T
A
G
A
G
T
0.019569
0.011742
0.02544
0.015656
0.021526
0.029354
0.007828
0.019569
0.035225
0.052838
0.072407
0.003914
0.017613
0.033268
0.021526
0.037182
0.056751
0.060665
0.066536
0.011742
0.015656
0.019569
0.015656
0.082192
0.019569
0.027397
0.033268
0.054795
0.062622
0.003914
0.011742
0.033268
1
2,616
A
A
A
T
T
T
C
C
T
T
G
G
C
C
T
C
C
T
C
G
A
A
G
T
C
A
C
A
G
A
T
C
T
C
C
T
C
T
A
T
G
C
A
C
T
C
C
C
G
C
T
C
C
A
G
G
C
T
G
C
T
G
T
G
A
G
0.017613
0.013699
0.027397
0.019569
0.023483
0.027397
0.007828
0.021526
0.037182
0.052838
0.072407
0.003914
0.017613
0.029354
0.021526
0.037182
0.060665
0.058708
0.062622
0.011742
0.015656
0.015656
0.015656
0.080235
0.027397
0.023483
0.033268
0.050881
0.064579
0.003914
0.011742
0.033268
1
2,617
G
C
T
G
C
G
G
C
A
G
T
C
G
C
A
G
C
T
G
A
A
G
C
T
G
C
C
G
A
T
G
C
C
G
T
C
G
A
T
G
C
A
C
G
T
G
C
C
G
T
G
C
C
C
G
C
A
G
C
A
C
A
G
G
C
A
0
0.005871
0.017613
0.005871
0.013699
0.033268
0.023483
0.009785
0.02544
0.068493
0.039139
0
0.013699
0.007828
0.017613
0.043053
0.072407
0.041096
0.082192
0.074364
0.015656
0.09002
0.013699
0.039139
0.009785
0.023483
0.07045
0.088063
0.029354
0.007828
0.001957
0.015656
1
2,618
G
C
C
G
C
C
C
G
C
C
A
G
C
A
T
C
C
A
C
C
T
C
T
C
C
C
C
C
T
C
A
C
C
G
C
G
C
T
G
G
C
A
G
A
A
G
C
G
G
C
C
C
T
C
C
C
A
G
C
C
G
C
T
G
C
A
0
0.005871
0.021526
0.007828
0.017613
0.037182
0.023483
0.011742
0.023483
0.068493
0.039139
0.001957
0.013699
0.007828
0.021526
0.04501
0.07045
0.04501
0.086106
0.062622
0.017613
0.076321
0.015656
0.033268
0.011742
0.027397
0.066536
0.082192
0.027397
0.011742
0.001957
0.017613
1
2,619
C
G
C
C
G
C
C
C
G
C
C
A
G
C
A
T
C
C
A
C
C
T
C
T
C
C
C
C
C
T
C
A
C
C
G
C
G
C
T
G
G
C
A
G
A
A
G
C
G
G
C
C
C
T
C
C
C
A
G
C
C
G
C
T
G
T
0
0.005871
0.021526
0.007828
0.017613
0.037182
0.023483
0.011742
0.023483
0.066536
0.039139
0.001957
0.013699
0.009785
0.021526
0.04501
0.07045
0.04501
0.086106
0.062622
0.017613
0.076321
0.015656
0.033268
0.011742
0.027397
0.066536
0.082192
0.027397
0.011742
0.001957
0.017613
1
2,620
A
G
C
G
G
C
T
G
G
G
A
G
G
G
C
C
G
C
T
T
C
T
G
C
C
A
G
C
G
C
G
G
T
G
A
G
G
G
G
G
A
G
A
G
G
T
G
G
A
T
G
C
T
G
G
C
G
G
G
C
G
G
C
G
G
C
0
0.005871
0.021526
0.007828
0.017613
0.037182
0.023483
0.011742
0.023483
0.064579
0.039139
0.001957
0.015656
0.009785
0.021526
0.04501
0.07045
0.04501
0.086106
0.062622
0.017613
0.076321
0.015656
0.033268
0.011742
0.027397
0.066536
0.082192
0.027397
0.011742
0.001957
0.017613
1
2,621
A
G
C
G
C
C
G
C
C
A
G
C
C
C
A
C
C
T
C
C
T
C
T
A
G
G
C
A
G
T
A
A
T
G
C
G
T
G
C
A
G
C
C
G
C
C
G
T
T
G
T
C
C
A
G
C
G
A
G
C
A
A
T
T
G
G
0.001957
0.011742
0.011742
0.009785
0.019569
0.029354
0.021526
0.009785
0.015656
0.066536
0.048924
0.001957
0.009785
0.009785
0.017613
0.043053
0.076321
0.041096
0.105675
0.054795
0.015656
0.084149
0.011742
0.041096
0.013699
0.015656
0.066536
0.088063
0.027397
0.007828
0.001957
0.019569
1
2,622
A
T
C
C
G
C
G
G
C
T
C
A
T
T
G
A
T
G
G
G
A
A
G
A
T
G
A
C
C
A
G
G
C
G
G
G
G
A
G
A
C
A
G
C
C
C
C
T
G
G
C
A
G
G
T
G
G
G
A
G
G
C
G
A
G
T
0.009785
0.013699
0.035225
0.005871
0.013699
0.043053
0.009785
0.021526
0.037182
0.033268
0.074364
0.003914
0.02544
0.031311
0.021526
0.041096
0.064579
0.056751
0.080235
0.019569
0.007828
0.021526
0.007828
0.058708
0.031311
0.027397
0.050881
0.046967
0.060665
0.005871
0.001957
0.037182
1
2,623
A
C
G
T
G
A
G
C
A
G
C
C
G
G
T
G
C
T
G
C
C
T
C
G
C
C
T
C
C
C
A
C
C
T
G
C
C
A
G
G
G
G
C
T
G
T
C
T
C
C
C
C
G
C
C
T
G
G
T
C
A
T
C
T
T
G
0.017613
0.015656
0.035225
0.003914
0.015656
0.039139
0.009785
0.021526
0.039139
0.037182
0.074364
0.001957
0.023483
0.029354
0.019569
0.039139
0.066536
0.052838
0.080235
0.019569
0.007828
0.021526
0.007828
0.060665
0.031311
0.02544
0.050881
0.046967
0.060665
0.005871
0.003914
0.035225
1
2,624
G
G
A
C
C
T
G
G
A
C
A
T
C
A
A
G
G
A
G
G
T
C
T
T
C
G
T
C
C
A
C
C
C
C
A
A
C
T
A
C
A
G
C
A
A
G
A
G
C
A
C
C
A
C
C
G
A
C
A
A
T
G
A
C
A
T
0.003914
0.009785
0.02544
0.007828
0.023483
0.039139
0.015656
0.027397
0.041096
0.039139
0.056751
0.005871
0.011742
0.017613
0.019569
0.056751
0.074364
0.054795
0.060665
0.035225
0.015656
0.031311
0.007828
0.056751
0.023483
0.033268
0.062622
0.068493
0.041096
0.005871
0
0.027397
1
2,625
C
T
G
G
G
C
C
A
G
G
T
G
C
A
G
C
A
G
T
G
C
G
A
T
G
T
C
A
T
T
G
T
C
G
G
T
G
G
T
G
C
T
C
T
T
G
C
T
G
T
A
G
T
T
G
G
G
G
T
G
G
A
C
G
A
G
0.003914
0.009785
0.02544
0.007828
0.02544
0.039139
0.013699
0.027397
0.039139
0.039139
0.056751
0.003914
0.011742
0.023483
0.021526
0.054795
0.072407
0.052838
0.060665
0.033268
0.017613
0.033268
0.005871
0.060665
0.021526
0.035225
0.062622
0.064579
0.039139
0.005871
0
0.031311
1
2,626
C
T
A
C
A
G
C
A
A
G
A
G
C
A
C
C
A
C
C
G
A
C
A
A
T
G
A
C
A
T
C
G
C
A
C
T
G
C
T
G
C
A
C
C
T
G
G
C
C
C
A
G
C
C
C
G
C
C
A
C
C
C
T
C
T
T
0.003914
0.011742
0.02544
0.007828
0.027397
0.039139
0.013699
0.02544
0.043053
0.041096
0.056751
0.003914
0.011742
0.027397
0.021526
0.052838
0.074364
0.050881
0.060665
0.031311
0.017613
0.027397
0.005871
0.060665
0.023483
0.035225
0.062622
0.060665
0.037182
0.005871
0
0.033268
1
2,627
A
C
T
G
C
T
G
C
A
C
C
T
G
G
C
C
C
A
G
C
C
C
G
C
C
A
C
C
C
T
C
T
C
G
C
A
G
A
C
C
A
T
A
G
T
G
C
C
C
A
T
C
T
G
C
C
T
C
C
C
G
G
A
C
A
T
0.003914
0.009785
0.02544
0.007828
0.027397
0.037182
0.009785
0.023483
0.041096
0.041096
0.058708
0.003914
0.015656
0.031311
0.021526
0.046967
0.072407
0.046967
0.060665
0.035225
0.019569
0.029354
0.005871
0.060665
0.021526
0.033268
0.066536
0.066536
0.039139
0.005871
0
0.031311
1
2,628
C
T
C
T
C
G
G
C
T
G
C
T
G
T
G
G
T
A
G
C
C
C
C
A
G
C
C
C
G
T
C
A
C
G
A
G
G
G
T
C
T
C
C
T
G
G
C
C
G
G
C
C
T
G
A
T
T
G
A
G
C
T
C
G
C
T
0.001957
0.011742
0.021526
0.007828
0.027397
0.04501
0.011742
0.019569
0.035225
0.041096
0.054795
0.003914
0.015656
0.035225
0.021526
0.048924
0.066536
0.054795
0.062622
0.037182
0.02544
0.035225
0.005871
0.056751
0.019569
0.037182
0.058708
0.060665
0.039139
0.005871
0
0.031311
1
2,629
G
C
T
C
A
A
T
C
A
G
G
C
C
G
G
C
C
A
G
G
A
G
A
C
C
C
T
C
G
T
G
A
C
G
G
G
C
T
G
G
G
G
C
T
A
C
C
A
C
A
G
C
A
G
C
C
G
A
G
A
G
A
A
G
G
T
0.001957
0.011742
0.021526
0.007828
0.027397
0.04501
0.011742
0.019569
0.035225
0.041096
0.056751
0.003914
0.015656
0.035225
0.021526
0.048924
0.066536
0.054795
0.060665
0.035225
0.02544
0.033268
0.005871
0.058708
0.019569
0.037182
0.058708
0.062622
0.039139
0.005871
0
0.031311
1
2,630
C
T
T
G
G
C
C
T
C
C
T
T
C
T
C
T
C
G
G
C
T
G
C
T
G
T
G
G
T
A
G
C
C
C
C
A
G
C
C
C
G
T
C
A
C
G
A
G
G
G
T
C
T
C
C
T
G
G
C
C
G
G
C
C
T
T
0.001957
0.011742
0.021526
0.007828
0.029354
0.04501
0.011742
0.017613
0.035225
0.043053
0.056751
0.003914
0.015656
0.035225
0.021526
0.048924
0.066536
0.054795
0.060665
0.035225
0.02544
0.033268
0.005871
0.058708
0.019569
0.037182
0.056751
0.062622
0.039139
0.005871
0
0.031311
1
2,631
A
C
C
A
G
G
A
A
C
C
A
G
G
T
G
C
C
G
T
G
G
A
A
G
G
A
G
G
C
G
A
C
C
A
T
G
G
G
C
C
C
C
C
C
A
C
T
G
T
C
G
C
C
C
T
C
G
C
A
G
G
C
A
T
C
T
0.011742
0.017613
0.031311
0.009785
0.041096
0.037182
0.013699
0.011742
0.027397
0.048924
0.054795
0
0.017613
0.043053
0.02544
0.043053
0.056751
0.050881
0.062622
0.035225
0.023483
0.027397
0.007828
0.046967
0.023483
0.031311
0.046967
0.064579
0.039139
0.009785
0.009785
0.029354
1
2,632
G
G
G
G
C
T
T
C
C
T
T
G
T
C
T
C
T
G
A
T
G
T
G
C
C
C
A
T
G
G
A
T
C
C
A
G
T
C
G
A
G
G
T
A
G
C
G
G
C
T
G
A
C
T
T
T
G
G
T
G
T
A
A
A
C
G
0.015656
0.023483
0.035225
0.013699
0.048924
0.033268
0.007828
0.019569
0.029354
0.039139
0.052838
0.005871
0.019569
0.054795
0.02544
0.04501
0.050881
0.050881
0.064579
0.021526
0.015656
0.017613
0.011742
0.043053
0.027397
0.027397
0.04501
0.046967
0.04501
0.013699
0.019569
0.029354
1
2,633
T
A
C
A
C
C
A
A
A
G
T
C
A
G
C
C
G
C
T
A
C
C
T
C
G
A
C
T
G
G
A
T
C
C
A
T
G
G
G
C
A
C
A
T
C
A
G
A
G
A
C
A
A
G
G
A
A
G
C
C
C
C
C
C
A
G
0.015656
0.023483
0.035225
0.013699
0.048924
0.033268
0.007828
0.019569
0.029354
0.039139
0.050881
0.005871
0.019569
0.054795
0.02544
0.04501
0.050881
0.052838
0.068493
0.021526
0.015656
0.017613
0.011742
0.041096
0.027397
0.027397
0.04501
0.046967
0.043053
0.013699
0.019569
0.029354
1
2,634
C
C
C
G
C
T
G
G
A
G
C
T
G
A
A
G
A
A
G
C
G
G
C
T
G
A
A
G
A
A
G
C
T
G
T
C
G
G
A
G
C
T
G
A
C
C
T
C
C
C
G
C
A
A
G
G
C
C
C
A
G
C
C
C
A
C
0.007828
0.013699
0.048924
0.001957
0.031311
0.019569
0.009785
0.011742
0.052838
0.058708
0.078278
0.001957
0.009785
0.02544
0.017613
0.031311
0.064579
0.046967
0.076321
0.017613
0.011742
0.015656
0.011742
0.076321
0.041096
0.021526
0.029354
0.068493
0.054795
0.005871
0.007828
0.029354
1
2,635
C
C
T
G
G
A
G
G
A
G
C
T
G
G
A
G
G
G
G
A
A
A
C
G
A
A
C
G
G
T
G
T
T
G
A
A
C
G
C
C
C
G
G
G
T
G
G
A
G
G
A
G
G
T
A
G
G
C
G
C
C
T
G
G
G
C
0.009785
0.015656
0.033268
0.003914
0.015656
0.033268
0.021526
0.009785
0.023483
0.056751
0.064579
0.003914
0.019569
0.019569
0.023483
0.031311
0.060665
0.066536
0.072407
0.031311
0.017613
0.058708
0.011742
0.048924
0.02544
0.019569
0.037182
0.072407
0.056751
0.013699
0.005871
0.015656
1
2,636
C
A
G
G
T
C
C
C
C
A
A
G
C
A
G
C
T
G
C
A
G
G
A
C
C
A
G
C
G
A
A
T
C
C
A
G
C
T
C
C
G
C
T
C
G
C
A
G
G
T
C
A
A
G
C
G
C
C
G
C
C
A
T
G
G
A
0.011742
0.019569
0.037182
0.009785
0.015656
0.035225
0.021526
0.013699
0.027397
0.054795
0.062622
0.003914
0.021526
0.015656
0.031311
0.031311
0.058708
0.066536
0.066536
0.02544
0.017613
0.048924
0.011742
0.050881
0.02544
0.019569
0.039139
0.060665
0.056751
0.013699
0.009785
0.015656
1
2,637
G
C
T
T
C
T
G
C
G
T
G
T
G
C
C
C
G
G
C
C
C
A
C
T
T
C
A
C
C
G
G
C
C
G
C
T
A
C
T
G
C
G
A
G
C
A
T
G
A
C
C
A
G
A
G
G
C
G
C
A
G
G
T
G
G
T
0.011742
0.017613
0.007828
0.001957
0.013699
0.037182
0.021526
0.017613
0.007828
0.02544
0.04501
0.001957
0.009785
0.009785
0.011742
0.043053
0.048924
0.035225
0.142857
0.078278
0.007828
0.135029
0.007828
0.031311
0.009785
0.017613
0.04501
0.086106
0.033268
0.011742
0.005871
0.019569
1
2,638
C
T
G
G
C
T
C
T
G
G
G
T
T
C
G
C
A
T
C
T
C
T
G
C
T
C
A
T
G
G
A
G
C
G
G
C
T
C
T
C
A
G
T
G
G
A
T
T
A
C
G
G
C
A
A
G
A
A
G
T
C
C
A
A
G
T
0.02544
0.02544
0.035225
0.021526
0.041096
0.029354
0.021526
0.019569
0.041096
0.039139
0.033268
0.013699
0.035225
0.046967
0.043053
0.04501
0.04501
0.068493
0.033268
0.015656
0.013699
0.015656
0.011742
0.041096
0.029354
0.02544
0.035225
0.046967
0.041096
0.015656
0.009785
0.035225
1
2,639
A
A
T
C
T
A
C
T
T
A
C
A
T
G
T
A
C
T
C
C
C
T
A
T
G
G
G
C
A
G
A
G
T
G
C
A
C
A
G
C
G
G
C
C
G
C
G
T
T
G
C
T
G
T
A
A
C
G
C
C
A
C
A
G
G
C
0.02544
0.021526
0.033268
0.023483
0.050881
0.017613
0.017613
0.029354
0.062622
0.031311
0.043053
0.009785
0.023483
0.048924
0.027397
0.037182
0.060665
0.037182
0.029354
0.009785
0.005871
0.013699
0.017613
0.054795
0.031311
0.035225
0.04501
0.039139
0.035225
0.021526
0.019569
0.041096
1
2,640
T
G
G
A
C
G
T
C
C
T
G
T
C
A
T
C
G
G
C
G
A
T
T
G
T
C
C
T
G
T
G
G
C
G
T
T
A
C
A
G
C
A
A
C
G
C
G
G
C
C
G
C
T
G
T
G
C
A
C
T
C
T
G
C
C
T
0.019569
0.019569
0.033268
0.019569
0.052838
0.017613
0.017613
0.031311
0.054795
0.035225
0.04501
0.007828
0.021526
0.052838
0.02544
0.041096
0.060665
0.041096
0.035225
0.009785
0.005871
0.013699
0.019569
0.050881
0.02544
0.035225
0.048924
0.043053
0.035225
0.023483
0.019569
0.037182
1
2,641
T
T
T
G
T
C
A
G
G
C
T
T
A
C
T
A
G
A
A
A
G
C
A
G
C
A
C
C
C
G
C
C
T
G
A
A
A
C
C
T
C
A
C
G
A
A
G
C
C
C
A
G
A
A
C
T
A
C
A
G
G
A
A
G
A
G
0.078278
0.031311
0.043053
0.046967
0.048924
0.023483
0.013699
0.027397
0.037182
0.033268
0.037182
0.021526
0.021526
0.019569
0.046967
0.039139
0.041096
0.033268
0.037182
0.011742
0.009785
0.007828
0.029354
0.021526
0.037182
0.021526
0.027397
0.041096
0.017613
0.021526
0.035225
0.037182
1
2,642
T
T
T
G
T
C
A
G
G
C
T
T
A
C
T
A
G
A
A
A
G
C
A
G
C
A
C
C
C
G
C
C
T
G
A
A
A
C
C
T
C
A
C
G
A
A
G
C
C
C
A
G
A
A
C
T
A
C
A
G
G
A
A
G
A
C
0.078278
0.031311
0.043053
0.046967
0.048924
0.023483
0.013699
0.027397
0.037182
0.033268
0.037182
0.021526
0.021526
0.019569
0.046967
0.039139
0.041096
0.033268
0.037182
0.011742
0.009785
0.007828
0.029354
0.021526
0.037182
0.021526
0.027397
0.041096
0.017613
0.021526
0.035225
0.037182
1
2,643
A
T
T
C
A
C
T
C
A
C
C
T
T
T
C
C
C
A
T
T
C
C
G
A
G
G
C
A
G
T
G
G
T
G
A
A
G
T
C
C
G
T
G
A
T
C
T
C
A
A
A
T
A
C
C
T
C
G
G
A
T
T
C
G
G
G
0.027397
0.013699
0.04501
0.02544
0.017613
0.029354
0.021526
0.019569
0.041096
0.033268
0.043053
0.005871
0.017613
0.017613
0.02544
0.031311
0.033268
0.035225
0.086106
0.052838
0.017613
0.04501
0.011742
0.046967
0.043053
0.031311
0.017613
0.056751
0.04501
0.009785
0.015656
0.037182
1
2,644
G
C
T
G
G
T
A
A
C
C
A
A
A
A
A
T
G
C
G
A
T
T
C
A
C
T
C
A
C
C
T
T
T
C
C
C
A
T
T
C
C
G
A
G
G
C
A
G
T
G
G
T
G
A
A
G
T
C
C
G
T
G
A
T
C
A
0.037182
0.015656
0.046967
0.02544
0.017613
0.029354
0.021526
0.019569
0.04501
0.033268
0.043053
0.005871
0.017613
0.013699
0.027397
0.031311
0.031311
0.035225
0.076321
0.050881
0.017613
0.043053
0.011742
0.048924
0.04501
0.031311
0.017613
0.054795
0.046967
0.009785
0.015656
0.033268
1
2,645
T
C
A
T
C
A
T
T
A
A
T
G
T
G
G
A
A
A
A
G
G
G
C
T
C
A
A
A
T
T
A
C
C
T
G
C
A
A
T
T
T
A
C
T
C
A
G
C
T
T
C
T
G
C
C
G
C
A
G
A
C
T
T
G
C
G
0.062622
0.027397
0.048924
0.048924
0.048924
0.017613
0.003914
0.027397
0.056751
0.035225
0.037182
0.021526
0.031311
0.039139
0.039139
0.031311
0.039139
0.021526
0.017613
0.009785
0.007828
0.005871
0.033268
0.035225
0.04501
0.021526
0.041096
0.015656
0.035225
0.017613
0.041096
0.035225
1
2,646
T
G
C
A
T
A
A
T
G
T
T
C
G
T
C
A
G
A
C
C
T
C
C
A
T
G
T
T
C
C
C
T
C
G
T
G
A
T
C
C
C
A
A
A
C
G
A
C
T
C
A
C
T
C
C
T
T
A
A
A
T
T
C
A
C
G
0.133072
0.039139
0.039139
0.062622
0.031311
0.013699
0.011742
0.048924
0.035225
0.013699
0.031311
0.04501
0.023483
0.023483
0.029354
0.02544
0.033268
0.021526
0.017613
0
0.013699
0.001957
0.02544
0.029354
0.039139
0.015656
0.027397
0.011742
0.027397
0.02544
0.072407
0.031311
1