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f_66_k3_w513_AAA
float64
f_67_k3_w513_AAC
float64
f_68_k3_w513_AAG
float64
f_69_k3_w513_AAT
float64
f_70_k3_w513_ACA
float64
f_71_k3_w513_ACC
float64
f_72_k3_w513_ACG
float64
f_73_k3_w513_ACT
float64
f_74_k3_w513_AGA
float64
f_75_k3_w513_AGC
float64
f_76_k3_w513_AGG
float64
f_77_k3_w513_ATA
float64
f_78_k3_w513_ATC
float64
f_79_k3_w513_ATG
float64
f_80_k3_w513_CAA
float64
f_81_k3_w513_CAC
float64
f_82_k3_w513_CAG
float64
f_83_k3_w513_CCA
float64
f_84_k3_w513_CCC
float64
f_85_k3_w513_CCG
float64
f_86_k3_w513_CGA
float64
f_87_k3_w513_CGC
float64
f_88_k3_w513_CTA
float64
f_89_k3_w513_CTC
float64
f_90_k3_w513_GAA
float64
f_91_k3_w513_GAC
float64
f_92_k3_w513_GCA
float64
f_93_k3_w513_GCC
float64
f_94_k3_w513_GGA
float64
f_95_k3_w513_GTA
float64
f_96_k3_w513_TAA
float64
f_97_k3_w513_TCA
float64
target
int64
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T
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2,650
T
A
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2,651
G
A
A
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C
T
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C
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C
A
A
A
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G
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2,652
T
T
A
A
A
A
A
T
A
T
A
T
T
A
C
T
C
A
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C
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C
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C
T
C
C
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G
A
A
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T
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T
G
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1
2,653
T
A
A
G
T
T
T
C
G
T
T
G
C
A
A
A
A
C
T
G
A
C
A
A
A
T
G
T
A
T
T
C
C
A
T
T
C
T
G
G
T
G
G
A
A
A
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G
T
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A
C
A
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C
G
T
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T
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A
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1
2,654
T
A
A
G
G
C
C
T
A
C
A
A
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A
C
T
C
T
C
A
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C
T
C
C
T
G
T
A
A
T
C
C
A
A
G
G
A
C
G
C
T
T
C
C
C
C
A
C
T
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A
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G
A
C
C
A
T
A
G
G
C
T
G
0.121331
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1
2,655
A
A
T
T
A
C
T
T
C
A
A
G
G
A
T
A
T
C
C
T
C
T
A
T
T
C
T
T
A
A
G
G
T
T
T
C
T
T
C
C
C
C
C
T
A
A
A
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C
A
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T
T
A
G
G
C
A
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A
A
G
T
T
C
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1
2,656
A
A
C
A
C
C
A
G
C
A
G
G
C
A
A
A
A
T
C
A
A
C
T
C
C
C
C
A
G
T
C
A
T
G
T
A
A
G
T
A
G
A
G
T
T
C
A
A
C
A
T
T
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C
C
A
A
C
T
G
C
A
T
G
T
C
0.082192
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0.064579
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1
2,657
A
A
C
A
G
A
C
C
A
A
C
A
A
A
A
T
G
G
G
A
G
G
A
T
T
T
G
A
A
A
T
T
C
G
G
A
A
T
C
C
A
C
A
G
A
C
C
C
C
A
G
G
G
A
T
T
A
A
C
T
G
C
A
G
T
T
0.058708
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1
2,658
T
A
C
T
C
T
C
C
C
T
C
T
C
C
T
C
C
G
A
G
T
C
A
G
A
G
T
A
C
C
C
C
T
G
A
G
G
G
G
T
A
A
T
G
C
T
C
T
G
C
A
A
G
T
A
A
G
C
C
C
G
G
T
T
C
C
0.031311
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0.029354
1
2,659
C
C
G
C
C
G
C
T
T
C
C
C
G
C
T
C
C
T
C
C
G
C
C
T
C
C
C
G
C
T
T
G
C
A
G
T
A
G
G
A
A
T
A
C
C
T
G
T
G
A
T
T
C
A
T
G
T
G
C
T
G
C
G
A
G
T
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0.017613
0.031311
1
2,660
C
C
C
G
C
T
T
G
C
A
G
T
A
G
G
A
A
T
A
C
C
T
G
T
G
A
T
T
C
A
T
G
T
G
C
T
G
C
G
A
G
T
A
C
G
A
G
C
C
C
G
A
G
T
G
T
G
A
G
A
A
G
C
G
C
C
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1
2,661
C
C
G
A
G
T
G
T
G
A
G
A
A
G
C
G
C
T
T
G
C
C
A
C
A
T
T
T
A
T
C
A
C
A
C
T
G
A
T
A
G
G
G
C
T
T
C
T
C
G
C
C
C
G
A
G
T
G
A
A
G
C
C
T
T
T
0.027397
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1
2,662
G
C
A
C
C
A
C
C
T
T
A
T
C
G
A
G
C
A
C
T
C
A
A
G
G
C
T
T
C
A
C
T
C
G
G
G
C
G
A
G
A
A
G
C
C
C
T
A
T
C
A
G
T
G
T
G
A
T
A
A
A
T
G
T
G
G
0.027397
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0.017613
0.037182
0.027397
0.037182
0.027397
0.02544
0.037182
1
2,663
A
T
T
T
A
T
C
A
C
A
C
T
G
A
T
A
G
G
G
C
T
T
C
T
C
G
C
C
C
G
A
G
T
G
A
A
G
C
C
T
T
G
A
G
T
G
C
T
C
G
A
T
A
A
G
G
T
G
G
T
G
C
T
T
G
G
0.029354
0.013699
0.048924
0.023483
0.037182
0.023483
0.007828
0.037182
0.043053
0.037182
0.037182
0.013699
0.031311
0.033268
0.023483
0.046967
0.033268
0.02544
0.037182
0.027397
0.029354
0.041096
0.011742
0.060665
0.037182
0.017613
0.037182
0.027397
0.037182
0.027397
0.02544
0.037182
1
2,664
G
A
T
A
G
G
G
C
T
T
C
T
C
G
C
C
C
G
A
G
T
G
A
A
G
C
C
T
T
G
A
G
T
G
C
T
C
G
A
T
A
A
G
G
T
G
G
T
G
C
T
T
G
T
G
T
T
T
A
A
A
C
G
C
T
C
0.033268
0.015656
0.048924
0.02544
0.037182
0.02544
0.007828
0.037182
0.04501
0.039139
0.035225
0.013699
0.029354
0.033268
0.023483
0.046967
0.033268
0.023483
0.035225
0.02544
0.027397
0.041096
0.013699
0.058708
0.039139
0.017613
0.037182
0.023483
0.035225
0.027397
0.027397
0.037182
1
2,665
T
A
A
G
C
T
G
T
T
A
C
T
C
T
T
T
G
A
T
T
T
A
C
G
A
C
T
G
C
T
C
A
T
T
T
C
A
A
C
A
A
A
T
T
C
A
A
A
T
C
C
T
T
T
A
A
A
A
A
A
A
T
T
G
G
C
0.117417
0.029354
0.058708
0.068493
0.037182
0.019569
0.011742
0.035225
0.050881
0.023483
0.029354
0.031311
0.031311
0.02544
0.031311
0.027397
0.031311
0.011742
0.007828
0
0.011742
0
0.023483
0.02544
0.04501
0.011742
0.027397
0.011742
0.011742
0.035225
0.078278
0.039139
1
2,666
A
T
A
A
C
G
G
G
A
C
G
A
T
T
T
T
T
G
C
G
T
A
T
G
G
G
C
A
G
A
C
T
T
C
A
T
C
A
G
G
A
A
A
A
A
C
C
C
A
C
A
C
C
A
T
G
G
A
G
G
T
A
A
G
A
C
0.111546
0.033268
0.035225
0.080235
0.043053
0.015656
0.011742
0.033268
0.041096
0.011742
0.013699
0.043053
0.021526
0.058708
0.039139
0.021526
0.029354
0.033268
0.009785
0.003914
0.003914
0.003914
0.011742
0.023483
0.050881
0.019569
0.023483
0.011742
0.023483
0.031311
0.058708
0.046967
1
2,667
T
T
T
T
G
C
G
T
A
T
G
G
G
C
A
G
A
C
T
T
C
A
T
C
A
G
G
A
A
A
A
A
C
C
C
A
C
A
C
C
A
T
G
G
A
G
G
T
A
A
G
A
T
T
A
C
A
A
T
G
T
G
C
T
C
T
0.111546
0.033268
0.035225
0.078278
0.043053
0.015656
0.011742
0.033268
0.043053
0.011742
0.013699
0.043053
0.021526
0.056751
0.039139
0.021526
0.029354
0.033268
0.009785
0.003914
0.003914
0.003914
0.013699
0.023483
0.054795
0.019569
0.023483
0.011742
0.023483
0.029354
0.054795
0.048924
1
2,668
A
G
A
T
A
A
T
A
C
A
A
A
T
A
A
A
G
A
A
C
A
A
A
T
T
A
C
C
T
T
T
T
C
G
C
T
C
C
C
A
G
C
C
A
A
A
T
C
A
A
C
C
A
A
A
T
A
A
A
G
T
T
T
C
C
T
0.111546
0.027397
0.048924
0.062622
0.035225
0.021526
0
0.027397
0.04501
0.029354
0.039139
0.04501
0.023483
0.039139
0.037182
0.015656
0.037182
0.023483
0.017613
0
0.001957
0.001957
0.027397
0.027397
0.043053
0.019569
0.031311
0.015656
0.02544
0.021526
0.058708
0.039139
1
2,669
T
A
G
A
T
A
A
T
A
C
A
A
A
T
A
A
A
G
A
A
C
A
A
A
T
T
A
C
C
T
T
T
T
C
G
C
T
C
C
C
A
G
C
C
A
A
A
T
C
A
A
C
C
A
A
A
T
A
A
A
G
T
T
T
C
A
0.111546
0.027397
0.048924
0.062622
0.035225
0.021526
0
0.027397
0.04501
0.029354
0.039139
0.04501
0.021526
0.041096
0.037182
0.015656
0.037182
0.023483
0.017613
0
0.001957
0.001957
0.027397
0.027397
0.043053
0.019569
0.031311
0.015656
0.02544
0.021526
0.058708
0.039139
1
2,670
C
A
A
A
C
T
A
A
T
G
A
T
T
C
T
G
A
C
T
G
T
A
A
C
A
C
A
A
A
A
A
A
C
T
A
A
G
A
A
T
G
A
T
A
T
G
A
C
T
G
T
T
T
G
G
A
G
T
G
A
A
G
A
A
G
A
0.144814
0.02544
0.062622
0.091977
0.029354
0.013699
0
0.052838
0.048924
0.015656
0.013699
0.039139
0.021526
0.031311
0.029354
0.017613
0.023483
0.017613
0.003914
0
0
0
0.031311
0.009785
0.056751
0.013699
0.015656
0.003914
0.013699
0.039139
0.093933
0.039139
1
2,671
A
T
G
A
G
A
G
C
C
A
C
C
A
G
T
G
C
A
C
C
C
A
T
C
T
G
C
A
T
T
A
C
C
T
G
G
C
T
G
C
T
C
A
G
C
T
T
G
G
C
T
G
C
C
T
T
C
T
T
G
G
C
C
A
T
G
0.050881
0.017613
0.054795
0.02544
0.037182
0.033268
0.001957
0.023483
0.048924
0.039139
0.041096
0.017613
0.021526
0.048924
0.037182
0.037182
0.058708
0.060665
0.027397
0.003914
0.009785
0.003914
0.011742
0.029354
0.031311
0.02544
0.054795
0.050881
0.021526
0.015656
0.029354
0.029354
1
2,672
T
G
G
T
T
G
A
T
C
A
C
T
T
A
C
A
T
C
A
C
T
G
A
C
A
T
G
C
T
T
G
G
T
C
A
C
T
T
C
C
T
T
G
A
C
G
T
G
A
A
C
A
G
T
G
T
C
C
C
G
G
G
T
C
T
G
0.027397
0.02544
0.04501
0.033268
0.046967
0.033268
0.009785
0.031311
0.046967
0.031311
0.031311
0.023483
0.027397
0.048924
0.043053
0.033268
0.052838
0.048924
0.031311
0.011742
0.001957
0.007828
0.015656
0.027397
0.033268
0.033268
0.035225
0.035225
0.023483
0.029354
0.027397
0.046967
1
2,673
C
C
T
G
G
A
A
G
A
G
G
A
G
T
A
C
A
G
G
A
A
G
A
C
G
C
A
C
C
T
C
A
C
T
G
G
C
A
T
T
A
A
T
G
C
C
A
C
T
C
T
G
A
A
C
A
G
C
A
G
T
C
A
C
A
A
0.078278
0.037182
0.037182
0.041096
0.072407
0.021526
0.003914
0.029354
0.054795
0.029354
0.037182
0.048924
0.021526
0.029354
0.033268
0.029354
0.064579
0.021526
0.017613
0
0
0.003914
0.027397
0.019569
0.041096
0.029354
0.027397
0.013699
0.021526
0.031311
0.041096
0.035225
1
2,674
G
C
C
T
A
C
C
T
T
C
T
T
T
G
A
C
C
A
T
C
C
C
A
A
C
A
G
C
C
A
G
G
C
A
C
T
T
C
T
G
A
A
A
T
C
G
G
C
A
G
T
A
C
T
G
A
C
A
G
C
G
A
T
T
C
A
0.091977
0.02544
0.033268
0.033268
0.035225
0.019569
0.013699
0.029354
0.033268
0.029354
0.043053
0.027397
0.015656
0.021526
0.033268
0.029354
0.050881
0.037182
0.043053
0.023483
0.015656
0.017613
0.015656
0.035225
0.039139
0.02544
0.043053
0.037182
0.046967
0.017613
0.017613
0.019569
1
2,675
T
G
A
C
C
A
T
C
C
C
A
A
C
A
G
C
C
A
G
G
C
A
C
T
T
C
T
G
A
A
A
T
C
G
G
C
A
G
T
A
C
T
G
A
C
A
G
C
G
A
T
T
C
C
G
G
C
G
A
C
G
C
T
T
G
T
0.093933
0.023483
0.039139
0.031311
0.035225
0.017613
0.013699
0.029354
0.039139
0.029354
0.043053
0.02544
0.015656
0.021526
0.033268
0.029354
0.050881
0.037182
0.039139
0.021526
0.015656
0.015656
0.015656
0.035225
0.04501
0.02544
0.043053
0.037182
0.046967
0.017613
0.013699
0.019569
1
2,676
G
A
C
A
G
C
G
A
T
T
C
C
G
G
C
G
A
C
G
C
T
T
G
T
C
C
A
C
T
G
G
G
C
A
G
T
T
T
T
T
A
T
T
T
G
C
T
A
A
A
C
A
C
A
C
G
T
A
T
T
T
T
G
C
A
T
0.107632
0.023483
0.037182
0.035225
0.035225
0.015656
0.011742
0.027397
0.039139
0.029354
0.041096
0.019569
0.015656
0.019569
0.033268
0.029354
0.054795
0.035225
0.043053
0.021526
0.013699
0.015656
0.013699
0.031311
0.048924
0.021526
0.04501
0.039139
0.04501
0.015656
0.013699
0.021526
1
2,677
G
C
T
T
G
T
C
C
A
C
T
G
G
G
C
A
G
T
T
T
T
T
A
T
T
T
G
C
T
A
A
A
C
A
C
A
C
G
T
A
T
T
T
T
G
C
A
T
T
T
T
T
T
T
G
C
A
C
T
G
T
G
C
G
C
A
0.107632
0.027397
0.035225
0.037182
0.037182
0.015656
0.013699
0.027397
0.035225
0.031311
0.039139
0.021526
0.017613
0.021526
0.035225
0.029354
0.052838
0.033268
0.043053
0.019569
0.013699
0.015656
0.011742
0.031311
0.046967
0.021526
0.04501
0.031311
0.04501
0.015656
0.017613
0.023483
1
2,678
T
G
C
T
C
A
C
C
T
T
A
A
A
G
A
A
G
C
C
T
T
T
G
C
A
G
C
C
C
T
C
A
C
A
G
G
T
G
C
G
C
A
C
G
C
C
G
T
A
G
T
G
T
T
G
G
C
A
G
G
C
C
G
C
G
T
0.007828
0.009785
0.02544
0.003914
0.021526
0.031311
0.029354
0.015656
0.023483
0.050881
0.048924
0
0.005871
0.017613
0.015656
0.046967
0.056751
0.04501
0.101761
0.060665
0.019569
0.046967
0.011742
0.04501
0.019569
0.033268
0.058708
0.078278
0.04501
0.007828
0.003914
0.011742
1
2,679
G
T
G
T
T
C
C
A
G
G
T
A
T
A
A
G
A
A
G
A
G
A
T
T
T
C
A
T
A
A
G
T
T
T
G
A
T
G
C
A
G
A
C
C
A
G
A
A
A
G
G
C
T
T
T
A
T
T
A
C
C
A
T
T
G
C
0.136986
0.037182
0.04501
0.056751
0.050881
0.013699
0.001957
0.029354
0.072407
0.015656
0.021526
0.07045
0.033268
0.029354
0.029354
0.015656
0.035225
0.015656
0.003914
0
0.005871
0.003914
0.033268
0.02544
0.046967
0.015656
0.007828
0.015656
0.007828
0.027397
0.060665
0.035225
1
2,680
C
T
T
C
G
G
G
G
G
C
C
A
T
G
T
A
G
C
G
C
T
T
G
G
T
G
C
C
C
A
C
A
C
G
G
G
G
A
T
T
G
T
T
C
C
C
C
A
C
A
T
C
A
A
G
C
T
G
A
T
T
G
G
T
G
G
0.050881
0.023483
0.050881
0.052838
0.035225
0.027397
0.007828
0.021526
0.039139
0.023483
0.037182
0.029354
0.046967
0.031311
0.048924
0.035225
0.031311
0.046967
0.046967
0.009785
0.013699
0.005871
0.021526
0.017613
0.048924
0.017613
0.023483
0.029354
0.037182
0.015656
0.031311
0.041096
1
2,681
G
A
T
T
G
G
T
G
C
T
C
T
G
G
G
A
A
T
G
C
A
T
G
A
C
T
G
C
C
A
G
G
C
C
T
G
A
A
A
G
G
A
A
G
A
A
G
A
T
A
A
C
A
A
T
G
T
A
A
T
C
A
A
C
C
T
0.052838
0.029354
0.048924
0.046967
0.033268
0.033268
0.001957
0.021526
0.043053
0.023483
0.039139
0.037182
0.046967
0.033268
0.048924
0.031311
0.031311
0.048924
0.04501
0.009785
0.009785
0.005871
0.023483
0.021526
0.043053
0.015656
0.023483
0.029354
0.035225
0.013699
0.033268
0.039139
1
2,682
C
T
T
T
A
A
A
T
C
T
C
G
A
T
G
G
G
C
A
A
T
G
G
C
T
G
G
T
T
T
C
C
C
T
T
G
G
G
T
C
C
C
A
A
A
T
A
T
C
T
C
T
A
T
G
T
G
C
A
A
A
T
G
T
G
A
0.084149
0.037182
0.029354
0.064579
0.050881
0.027397
0.003914
0.027397
0.04501
0.027397
0.013699
0.046967
0.02544
0.058708
0.039139
0.031311
0.031311
0.043053
0.021526
0
0.011742
0
0.02544
0.027397
0.039139
0.015656
0.037182
0.005871
0.023483
0.02544
0.050881
0.029354
1
2,683
C
T
T
T
A
A
A
T
C
T
C
G
A
T
G
G
G
C
A
A
T
G
G
C
T
G
G
T
T
T
C
C
C
T
T
G
G
G
T
C
C
C
A
A
A
T
A
T
C
T
C
T
A
T
G
T
G
C
A
A
A
T
G
T
G
T
0.084149
0.037182
0.029354
0.064579
0.050881
0.027397
0.003914
0.027397
0.04501
0.027397
0.013699
0.046967
0.02544
0.058708
0.039139
0.031311
0.031311
0.043053
0.021526
0
0.011742
0
0.02544
0.027397
0.039139
0.015656
0.037182
0.005871
0.023483
0.02544
0.050881
0.029354
1
2,684
T
T
A
T
C
C
T
T
G
T
A
C
T
T
A
C
C
T
A
A
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A
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G
T
G
T
T
G
T
A
C
A
A
T
T
C
C
G
T
T
T
C
G
0.062622
0.029354
0.039139
0.062622
0.035225
0.017613
0.007828
0.029354
0.046967
0.023483
0.043053
0.033268
0.029354
0.043053
0.033268
0.031311
0.031311
0.02544
0.027397
0.007828
0.003914
0
0.02544
0.04501
0.04501
0.011742
0.041096
0.017613
0.041096
0.017613
0.052838
0.039139
1
2,685
A
A
T
T
A
C
C
G
A
C
A
C
A
C
T
C
C
A
A
C
A
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T
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C
T
T
T
G
T
A
C
C
A
G
A
A
A
A
G
G
A
A
G
A
T
0.082192
0.037182
0.056751
0.041096
0.060665
0.017613
0.007828
0.037182
0.043053
0.029354
0.027397
0.027397
0.023483
0.041096
0.043053
0.031311
0.033268
0.037182
0.013699
0.005871
0.007828
0.001957
0.013699
0.033268
0.043053
0.019569
0.023483
0.011742
0.041096
0.035225
0.04501
0.027397
1
2,686
A
C
T
C
C
A
A
C
A
G
T
G
T
A
A
T
C
T
G
G
C
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A
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A
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A
A
A
A
G
G
A
A
G
A
C
C
A
G
A
G
C
C
A
C
T
T
A
0.093933
0.037182
0.052838
0.043053
0.060665
0.017613
0.007828
0.035225
0.041096
0.02544
0.027397
0.029354
0.023483
0.041096
0.043053
0.031311
0.033268
0.037182
0.013699
0.005871
0.007828
0.001957
0.013699
0.031311
0.043053
0.017613
0.023483
0.011742
0.041096
0.035225
0.046967
0.02544
1
2,687
T
C
A
T
T
C
G
T
G
T
A
C
A
T
C
A
G
G
A
A
G
T
G
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C
T
C
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T
A
C
A
A
A
G
A
A
C
A
G
T
G
G
C
T
C
G
C
C
C
0.09589
0.039139
0.054795
0.039139
0.058708
0.017613
0.009785
0.037182
0.041096
0.02544
0.027397
0.029354
0.023483
0.037182
0.043053
0.033268
0.029354
0.037182
0.013699
0.007828
0.007828
0.001957
0.013699
0.033268
0.043053
0.019569
0.019569
0.011742
0.043053
0.031311
0.046967
0.027397
1
2,688
A
A
G
T
G
G
C
C
T
T
T
T
C
A
T
T
C
T
G
T
G
G
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A
C
T
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C
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G
A
A
G
C
A
A
C
A
T
T
G
G
A
A
G
T
C
A
A
G
A
0.088063
0.033268
0.039139
0.072407
0.027397
0.033268
0
0.043053
0.035225
0.013699
0.029354
0.056751
0.029354
0.041096
0.033268
0.021526
0.031311
0.04501
0.009785
0.001957
0.001957
0
0.039139
0.011742
0.064579
0.009785
0.011742
0.009785
0.033268
0.041096
0.046967
0.04501
1
2,689
T
A
C
C
A
A
G
A
A
A
A
G
C
A
G
G
T
G
A
C
T
G
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A
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C
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A
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G
A
G
C
A
G
A
G
C
C
T
G
G
G
G
C
T
T
T
T
T
0.07045
0.021526
0.066536
0.041096
0.027397
0.02544
0.001957
0.039139
0.064579
0.023483
0.035225
0.041096
0.046967
0.029354
0.029354
0.027397
0.04501
0.029354
0.019569
0.001957
0.001957
0
0.019569
0.031311
0.060665
0.015656
0.013699
0.013699
0.027397
0.029354
0.039139
0.060665
1
2,690
C
T
G
A
G
A
A
T
T
A
A
C
A
T
T
T
T
C
C
C
T
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A
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A
G
A
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G
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A
A
C
G
G
T
T
A
C
C
A
T
C
C
T
C
A
G
C
A
G
C
0.11546
0.033268
0.043053
0.082192
0.023483
0.02544
0.001957
0.041096
0.041096
0.013699
0.019569
0.078278
0.015656
0.035225
0.041096
0.019569
0.019569
0.035225
0.013699
0.001957
0.003914
0
0.021526
0.031311
0.052838
0.007828
0.015656
0.009785
0.021526
0.031311
0.062622
0.041096
1
2,691
G
T
T
A
C
A
C
A
C
C
A
A
G
A
C
A
G
T
T
G
A
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A
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G
A
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C
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C
A
A
G
T
G
A
C
A
G
A
G
C
C
C
G
T
C
A
T
T
0.046967
0.027397
0.023483
0.054795
0.054795
0.021526
0.007828
0.035225
0.031311
0.029354
0.031311
0.035225
0.027397
0.050881
0.037182
0.048924
0.037182
0.043053
0.023483
0.005871
0.007828
0.001957
0.033268
0.035225
0.037182
0.02544
0.035225
0.015656
0.04501
0.017613
0.031311
0.041096
1
2,692
C
T
C
C
T
G
G
T
C
T
T
T
G
T
G
A
G
T
G
A
T
G
C
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A
T
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A
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G
G
A
A
T
G
G
A
C
A
G
C
A
A
A
C
T
A
G
C
A
G
G
C
A
T
C
G
T
A
0.072407
0.027397
0.02544
0.07045
0.058708
0.013699
0.007828
0.033268
0.027397
0.029354
0.029354
0.043053
0.023483
0.046967
0.041096
0.04501
0.033268
0.031311
0.013699
0.003914
0.009785
0.001957
0.029354
0.031311
0.037182
0.023483
0.033268
0.017613
0.033268
0.017613
0.043053
0.04501
1
2,693
C
T
T
T
A
T
T
G
T
G
T
T
G
A
G
G
T
C
G
T
C
A
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G
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C
C
A
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G
A
G
G
T
A
A
T
A
C
A
A
A
T
C
C
A
C
C
G
T
0.07045
0.029354
0.041096
0.037182
0.035225
0.037182
0.001957
0.027397
0.043053
0.039139
0.033268
0.021526
0.027397
0.027397
0.043053
0.033268
0.052838
0.048924
0.023483
0.015656
0.005871
0.015656
0.013699
0.037182
0.033268
0.021526
0.039139
0.023483
0.037182
0.019569
0.031311
0.033268
1
2,694
G
T
A
T
T
A
C
C
T
T
C
C
C
T
G
T
T
T
G
G
T
G
A
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A
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T
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G
G
T
G
A
A
A
T
T
T
C
A
G
C
C
A
A
A
G
G
G
G
0.027397
0.027397
0.017613
0.009785
0.029354
0.04501
0.013699
0.027397
0.015656
0.043053
0.050881
0.007828
0.019569
0.017613
0.029354
0.04501
0.046967
0.058708
0.068493
0.052838
0.009785
0.02544
0.039139
0.035225
0.021526
0.015656
0.031311
0.068493
0.048924
0.027397
0.003914
0.019569
1
2,695
G
C
A
G
C
C
A
A
A
A
A
T
G
T
A
G
T
A
T
T
A
C
C
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A
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C
T
C
C
G
T
T
T
G
G
T
G
C
C
G
G
T
G
A
A
C
0.033268
0.027397
0.023483
0.009785
0.029354
0.04501
0.013699
0.027397
0.017613
0.041096
0.052838
0.007828
0.017613
0.015656
0.031311
0.04501
0.04501
0.056751
0.066536
0.050881
0.007828
0.02544
0.037182
0.033268
0.02544
0.015656
0.031311
0.066536
0.048924
0.027397
0.003914
0.019569
1
2,696
T
G
C
A
C
A
T
T
G
G
T
G
T
C
C
G
C
T
T
T
G
C
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C
A
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A
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C
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T
G
A
A
A
C
C
T
C
C
A
G
T
G
A
T
T
G
G
G
A
0.099804
0.027397
0.054795
0.060665
0.033268
0.013699
0.005871
0.023483
0.02544
0.027397
0.039139
0.021526
0.027397
0.029354
0.046967
0.023483
0.021526
0.033268
0.04501
0.011742
0.019569
0.021526
0.015656
0.023483
0.035225
0.019569
0.035225
0.029354
0.041096
0.005871
0.062622
0.019569
1
2,697
C
C
C
C
C
A
G
C
C
C
C
T
A
G
G
T
C
T
C
C
T
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C
A
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G
T
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C
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G
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G
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C
G
G
T
G
A
C
G
G
C
G
A
T
G
A
A
C
T
G
A
G
T
C
T
G
0.031311
0.021526
0.029354
0.005871
0.035225
0.035225
0.027397
0.015656
0.023483
0.046967
0.04501
0.003914
0.009785
0.019569
0.013699
0.052838
0.04501
0.039139
0.054795
0.062622
0.013699
0.060665
0.02544
0.031311
0.02544
0.023483
0.037182
0.078278
0.033268
0.015656
0.017613
0.019569
1
2,698
G
C
C
T
C
G
C
C
C
C
C
A
G
C
C
C
C
T
A
G
G
T
C
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C
T
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A
C
A
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C
C
G
T
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C
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G
G
C
G
G
T
G
A
C
G
G
C
G
A
T
G
A
A
C
T
G
0.033268
0.021526
0.029354
0.007828
0.035225
0.035225
0.027397
0.015656
0.023483
0.04501
0.04501
0.003914
0.011742
0.019569
0.013699
0.052838
0.043053
0.039139
0.054795
0.062622
0.013699
0.060665
0.02544
0.031311
0.02544
0.023483
0.035225
0.076321
0.035225
0.015656
0.017613
0.019569
1
2,699
T
G
C
A
A
A
A
G
G
G
T
T
G
T
G
A
T
C
T
A
T
T
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C
A
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A
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C
A
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A
A
A
A
A
A
A
A
T
G
A
A
T
G
T
T
A
T
C
T
A
0.142857
0.027397
0.072407
0.052838
0.041096
0.017613
0.009785
0.021526
0.046967
0.023483
0.041096
0.043053
0.02544
0.023483
0.043053
0.02544
0.019569
0.019569
0.017613
0.001957
0.003914
0
0.019569
0.021526
0.060665
0.011742
0.011742
0.015656
0.029354
0.023483
0.046967
0.039139
1
2,700
T
A
C
T
T
A
C
G
T
G
T
C
A
T
A
A
T
T
A
T
C
C
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A
A
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C
C
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T
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C
A
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G
G
T
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G
T
G
A
T
C
T
A
T
T
T
T
C
A
G
T
T
G
T
G
C
0.138943
0.02544
0.074364
0.048924
0.039139
0.023483
0.011742
0.021526
0.048924
0.017613
0.041096
0.043053
0.02544
0.023483
0.04501
0.027397
0.017613
0.023483
0.017613
0.001957
0.003914
0.001957
0.017613
0.021526
0.058708
0.013699
0.011742
0.015656
0.027397
0.027397
0.04501
0.039139
1
2,701
G
G
G
A
A
C
A
A
T
G
A
T
G
G
T
G
C
A
C
A
A
A
G
G
C
T
T
A
G
A
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T
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G
C
C
T
T
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T
C
T
C
A
A
A
A
T
A
A
G
G
A
A
T
T
T
T
G
T
A
G
T
G
G
G
0.103718
0.027397
0.04501
0.09002
0.048924
0.011742
0
0.029354
0.039139
0.017613
0.021526
0.039139
0.039139
0.043053
0.056751
0.027397
0.023483
0.023483
0.013699
0.001957
0.001957
0
0.023483
0.015656
0.04501
0.007828
0.031311
0.017613
0.017613
0.027397
0.060665
0.048924
1
2,702
C
T
G
G
C
C
A
C
A
T
T
T
G
C
A
G
A
T
G
A
T
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A
C
A
C
T
T
C
T
T
T
T
G
C
A
G
T
G
C
T
T
C
0.082192
0.027397
0.050881
0.062622
0.048924
0.021526
0.001957
0.02544
0.039139
0.021526
0.039139
0.027397
0.019569
0.04501
0.058708
0.029354
0.02544
0.033268
0.021526
0.007828
0.001957
0.003914
0.021526
0.027397
0.046967
0.007828
0.04501
0.027397
0.031311
0.033268
0.035225
0.029354
1
2,703
T
G
A
G
A
C
A
G
T
T
A
A
T
G
A
T
T
T
C
C
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T
T
G
T
G
T
T
C
A
A
A
A
T
A
T
G
A
A
0.064579
0.037182
0.023483
0.062622
0.039139
0.027397
0.009785
0.02544
0.041096
0.02544
0.02544
0.041096
0.037182
0.054795
0.037182
0.029354
0.04501
0.039139
0.013699
0.005871
0.009785
0.001957
0.007828
0.041096
0.048924
0.013699
0.02544
0.017613
0.02544
0.021526
0.037182
0.064579
1
2,704
T
C
A
G
G
A
G
T
T
A
T
C
G
A
A
C
A
T
G
A
G
A
C
A
G
T
T
A
A
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G
A
T
T
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C
C
G
A
G
A
G
A
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A
T
G
A
T
G
T
A
T
A
A
A
G
C
T
A
T
A
C
A
G
0.064579
0.039139
0.023483
0.066536
0.039139
0.027397
0.009785
0.029354
0.041096
0.023483
0.021526
0.043053
0.037182
0.054795
0.037182
0.029354
0.043053
0.039139
0.011742
0.005871
0.009785
0.001957
0.009785
0.037182
0.046967
0.013699
0.02544
0.015656
0.023483
0.023483
0.04501
0.060665
1
2,705
G
G
C
C
C
G
T
G
G
T
C
G
A
G
C
C
A
G
A
G
C
T
G
A
T
G
A
G
A
G
C
A
C
C
T
A
C
G
T
C
C
T
G
G
T
T
G
C
T
C
A
C
A
G
T
G
G
T
T
C
A
G
G
A
G
G
0.074364
0.043053
0.031311
0.060665
0.041096
0.02544
0.009785
0.033268
0.041096
0.027397
0.019569
0.050881
0.027397
0.048924
0.039139
0.02544
0.039139
0.031311
0.009785
0.005871
0.009785
0.001957
0.013699
0.039139
0.046967
0.015656
0.019569
0.013699
0.017613
0.027397
0.048924
0.060665
1
2,706
G
A
G
C
A
A
C
C
A
G
G
A
C
G
T
A
G
G
T
G
C
T
C
T
C
A
T
C
A
G
C
T
C
T
G
G
C
T
C
G
A
C
C
A
C
G
G
G
C
C
T
G
A
A
A
A
C
A
C
A
A
A
T
A
A
T
0.07045
0.039139
0.031311
0.060665
0.039139
0.027397
0.009785
0.033268
0.039139
0.027397
0.021526
0.050881
0.031311
0.052838
0.039139
0.02544
0.037182
0.033268
0.009785
0.005871
0.009785
0.001957
0.013699
0.039139
0.043053
0.015656
0.019569
0.015656
0.017613
0.027397
0.048924
0.062622
1
2,707
C
C
A
G
G
A
C
G
T
A
G
G
T
G
C
T
C
T
C
A
T
C
A
G
C
T
C
T
G
G
C
T
C
G
A
C
C
A
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G
G
G
C
C
T
G
A
A
A
A
C
A
C
A
A
A
T
A
A
A
T
C
A
A
G
T
0.07045
0.039139
0.029354
0.062622
0.039139
0.027397
0.009785
0.031311
0.039139
0.027397
0.023483
0.046967
0.031311
0.052838
0.041096
0.02544
0.037182
0.033268
0.009785
0.005871
0.009785
0.001957
0.013699
0.041096
0.043053
0.015656
0.019569
0.017613
0.017613
0.027397
0.04501
0.064579
1
2,708
G
A
G
G
T
A
T
T
T
G
A
A
T
G
T
A
C
C
T
G
G
A
C
C
A
T
G
G
C
T
A
T
T
T
C
A
T
T
G
G
T
G
A
C
G
A
G
A
C
C
A
T
A
A
C
G
G
A
T
A
A
C
A
A
T
A
0.123288
0.04501
0.035225
0.082192
0.058708
0.019569
0.003914
0.023483
0.041096
0.023483
0.021526
0.046967
0.023483
0.043053
0.037182
0.019569
0.033268
0.023483
0
0.001957
0.005871
0.003914
0.029354
0.011742
0.039139
0.013699
0.027397
0.007828
0.017613
0.027397
0.086106
0.023483
1
2,709
T
T
C
A
T
T
G
G
T
G
A
C
G
A
G
A
C
C
A
T
A
A
C
G
G
A
T
A
A
C
A
A
T
G
T
T
A
C
A
T
T
C
T
T
T
A
A
T
A
T
C
C
A
G
A
C
C
T
T
C
T
T
C
T
G
A
0.123288
0.04501
0.033268
0.084149
0.058708
0.019569
0.003914
0.021526
0.039139
0.019569
0.019569
0.04501
0.027397
0.046967
0.043053
0.019569
0.033268
0.027397
0
0.001957
0.005871
0.003914
0.02544
0.007828
0.039139
0.013699
0.031311
0.011742
0.017613
0.02544
0.080235
0.02544
1
2,710
A
T
T
G
G
T
G
A
C
G
A
G
A
C
C
A
T
A
A
C
G
G
A
T
A
A
C
A
A
T
G
T
T
A
C
A
T
T
C
T
T
T
A
A
T
A
T
C
C
A
G
A
C
C
T
T
C
T
T
C
T
G
C
C
A
C
0.125245
0.043053
0.035225
0.084149
0.056751
0.019569
0.003914
0.021526
0.041096
0.019569
0.019569
0.04501
0.027397
0.04501
0.043053
0.019569
0.033268
0.027397
0
0.001957
0.005871
0.003914
0.02544
0.007828
0.039139
0.013699
0.031311
0.011742
0.017613
0.02544
0.080235
0.02544
1
2,711
C
C
A
C
T
G
T
G
G
T
A
G
C
G
A
T
A
A
G
C
A
G
A
T
T
T
A
T
T
T
T
T
C
C
A
G
T
G
C
G
A
A
A
T
T
T
A
C
T
A
A
T
G
A
C
T
T
C
T
T
T
T
T
G
T
T
0.135029
0.041096
0.033268
0.091977
0.058708
0.019569
0.003914
0.019569
0.043053
0.015656
0.015656
0.037182
0.031311
0.04501
0.04501
0.021526
0.02544
0.033268
0.001957
0.001957
0.005871
0.003914
0.02544
0.009785
0.037182
0.015656
0.021526
0.009785
0.021526
0.023483
0.082192
0.023483
1
2,712
A
G
A
A
T
G
A
A
C
A
A
A
A
A
G
A
A
G
T
C
A
T
T
A
G
T
A
A
A
T
T
T
C
G
C
A
C
T
G
G
A
A
A
A
A
T
A
A
A
T
C
T
G
C
T
T
A
T
C
G
C
T
A
C
C
T
0.127202
0.041096
0.033268
0.09002
0.058708
0.019569
0.003914
0.019569
0.043053
0.015656
0.015656
0.037182
0.033268
0.048924
0.04501
0.021526
0.02544
0.035225
0.001957
0.001957
0.005871
0.003914
0.02544
0.009785
0.039139
0.015656
0.021526
0.009785
0.023483
0.023483
0.078278
0.02544
1
2,713
T
A
T
T
T
T
T
C
C
A
G
T
G
C
G
A
A
A
T
T
T
A
C
T
A
A
T
G
A
C
T
T
C
T
T
T
T
T
G
T
T
C
A
T
T
C
T
G
T
A
G
A
A
A
C
A
T
T
T
T
A
A
T
A
A
G
0.121331
0.039139
0.031311
0.088063
0.056751
0.021526
0.003914
0.021526
0.043053
0.013699
0.015656
0.037182
0.035225
0.046967
0.04501
0.023483
0.027397
0.041096
0.003914
0.001957
0.005871
0.003914
0.02544
0.009785
0.039139
0.017613
0.019569
0.009785
0.027397
0.023483
0.074364
0.02544
1
2,714
C
A
C
T
C
T
G
T
C
G
T
G
T
T
T
T
T
G
T
A
A
A
G
A
T
T
A
T
T
C
C
T
C
G
T
G
C
T
G
A
T
T
C
C
T
C
A
G
T
C
C
T
A
G
T
A
T
A
T
T
G
C
T
C
C
T
0.11546
0.023483
0.052838
0.066536
0.037182
0.013699
0.007828
0.031311
0.054795
0.031311
0.019569
0.052838
0.021526
0.027397
0.037182
0.023483
0.039139
0.033268
0.007828
0
0.009785
0.005871
0.011742
0.033268
0.058708
0.019569
0.013699
0.013699
0.02544
0.021526
0.046967
0.043053
1
2,715
A
A
T
G
G
A
G
C
A
A
T
A
T
A
C
T
A
G
G
A
C
T
G
A
G
G
A
A
T
C
A
G
C
A
C
G
A
G
G
A
A
T
A
A
T
C
T
T
T
A
C
A
A
A
A
A
C
A
C
G
A
C
A
G
A
T
0.11546
0.023483
0.052838
0.066536
0.037182
0.013699
0.007828
0.031311
0.054795
0.031311
0.017613
0.056751
0.021526
0.027397
0.037182
0.023483
0.037182
0.033268
0.007828
0
0.009785
0.005871
0.011742
0.033268
0.058708
0.019569
0.013699
0.011742
0.02544
0.023483
0.046967
0.043053
1
2,716
G
T
A
C
A
A
T
G
A
G
G
C
C
C
T
A
C
A
A
A
T
T
A
A
T
G
A
C
A
C
A
A
T
T
C
G
A
A
T
G
A
T
A
G
A
T
G
C
G
T
A
T
A
C
T
C
A
T
C
T
T
G
A
A
A
C
0.09002
0.037182
0.052838
0.050881
0.037182
0.019569
0.005871
0.039139
0.037182
0.013699
0.02544
0.054795
0.037182
0.060665
0.041096
0.027397
0.02544
0.021526
0.013699
0
0.005871
0.003914
0.015656
0.021526
0.054795
0.011742
0.029354
0.013699
0.013699
0.02544
0.04501
0.068493
1
2,717
C
A
A
A
C
C
T
A
A
A
T
T
A
C
C
T
T
T
T
T
T
T
T
C
C
A
T
T
T
G
A
A
T
G
G
C
C
C
A
T
T
G
T
T
C
A
T
A
G
G
G
T
T
G
A
G
T
T
C
C
A
A
A
A
T
C
0.09589
0.041096
0.046967
0.076321
0.052838
0.013699
0
0.031311
0.064579
0.009785
0.023483
0.050881
0.033268
0.041096
0.046967
0.013699
0.015656
0.031311
0.011742
0
0
0
0.041096
0.023483
0.048924
0.023483
0.005871
0.003914
0.037182
0.019569
0.068493
0.027397
1
2,718
G
T
G
T
T
C
T
T
C
A
G
C
T
T
T
G
G
C
T
T
G
C
T
T
C
G
T
G
G
C
C
C
C
T
C
C
A
A
C
A
C
C
A
G
G
T
G
A
A
G
C
T
G
T
T
A
G
T
C
C
C
A
G
T
A
T
0.084149
0.031311
0.056751
0.062622
0.041096
0.013699
0.001957
0.043053
0.039139
0.031311
0.015656
0.058708
0.033268
0.04501
0.04501
0.029354
0.033268
0.02544
0.011742
0
0.001957
0
0.017613
0.021526
0.046967
0.017613
0.021526
0.011742
0.013699
0.021526
0.058708
0.064579
1
2,719
T
T
G
C
T
T
C
G
T
G
G
C
C
C
C
T
C
C
A
A
C
A
C
C
A
G
G
T
G
A
A
G
C
T
G
T
T
A
G
T
C
C
C
A
G
T
A
T
C
T
G
A
G
G
A
A
G
G
G
G
A
A
T
C
A
T
0.078278
0.031311
0.060665
0.060665
0.041096
0.013699
0.001957
0.043053
0.039139
0.033268
0.019569
0.052838
0.031311
0.039139
0.046967
0.029354
0.035225
0.02544
0.015656
0
0.001957
0
0.017613
0.021526
0.048924
0.017613
0.02544
0.015656
0.015656
0.021526
0.056751
0.058708
1
2,720
C
A
A
A
T
A
A
T
G
C
C
T
C
A
T
G
A
T
G
T
T
A
T
T
A
T
A
C
A
C
T
G
C
T
T
C
T
T
T
G
T
T
G
G
T
G
T
G
A
T
G
A
C
A
T
T
C
A
T
C
A
A
T
G
A
T
0.076321
0.033268
0.056751
0.046967
0.043053
0.015656
0.009785
0.043053
0.041096
0.033268
0.02544
0.043053
0.023483
0.039139
0.041096
0.033268
0.035225
0.029354
0.021526
0
0.005871
0
0.023483
0.027397
0.048924
0.021526
0.02544
0.015656
0.023483
0.021526
0.04501
0.050881
1
2,721
C
T
C
A
T
T
A
T
C
A
T
T
G
A
T
G
A
A
T
G
T
C
A
T
C
A
C
A
C
C
A
A
C
A
A
A
G
A
A
G
C
A
G
T
G
T
A
T
A
A
T
A
A
C
A
T
C
A
T
G
A
G
G
C
A
G
0.076321
0.033268
0.056751
0.04501
0.04501
0.015656
0.009785
0.041096
0.043053
0.033268
0.02544
0.043053
0.021526
0.041096
0.039139
0.033268
0.035225
0.029354
0.021526
0
0.005871
0
0.02544
0.02544
0.048924
0.023483
0.02544
0.015656
0.023483
0.021526
0.046967
0.048924
1
2,722
T
A
T
A
C
A
C
T
G
C
T
T
C
T
T
T
G
T
T
G
G
T
G
T
G
A
T
G
A
C
A
T
T
C
A
T
C
A
A
T
G
A
T
A
A
T
G
A
G
G
G
A
A
A
A
G
T
C
T
T
A
A
A
A
G
C
0.076321
0.033268
0.056751
0.04501
0.04501
0.013699
0.009785
0.041096
0.043053
0.033268
0.027397
0.041096
0.021526
0.041096
0.039139
0.033268
0.035225
0.027397
0.021526
0
0.005871
0
0.027397
0.027397
0.052838
0.021526
0.02544
0.015656
0.02544
0.021526
0.043053
0.048924
1
2,723
A
C
A
C
T
G
C
T
T
C
T
T
T
G
T
T
G
G
T
G
T
G
A
T
G
A
C
A
T
T
C
A
T
C
A
A
T
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A
T
A
A
T
G
A
G
G
G
A
A
A
A
G
T
C
T
T
A
A
A
A
G
A
A
A
C
0.076321
0.033268
0.054795
0.04501
0.04501
0.013699
0.009785
0.041096
0.043053
0.033268
0.027397
0.043053
0.023483
0.041096
0.037182
0.033268
0.035225
0.027397
0.021526
0
0.005871
0
0.027397
0.027397
0.052838
0.021526
0.02544
0.015656
0.02544
0.021526
0.043053
0.048924
1
2,724
C
A
A
C
T
T
C
T
G
G
A
A
A
T
G
A
T
A
T
T
T
T
C
A
G
T
T
G
G
G
T
A
T
C
A
C
C
A
C
T
T
A
A
T
C
C
A
A
T
A
A
C
A
C
G
A
T
A
C
C
A
T
T
T
C
G
0.11546
0.04501
0.048924
0.066536
0.039139
0.017613
0.007828
0.037182
0.027397
0.023483
0.023483
0.041096
0.037182
0.033268
0.046967
0.02544
0.033268
0.031311
0.005871
0.001957
0.007828
0.001957
0.007828
0.021526
0.041096
0.013699
0.015656
0.013699
0.02544
0.017613
0.072407
0.052838
1
2,725
C
A
C
A
T
T
T
T
T
T
T
A
A
G
G
T
A
C
T
G
C
T
A
G
T
T
G
A
A
C
A
G
C
T
C
T
T
C
C
G
C
A
A
G
G
A
G
T
T
C
C
A
A
C
C
A
T
T
T
T
T
G
A
A
G
T
0.09589
0.046967
0.046967
0.052838
0.046967
0.021526
0.005871
0.037182
0.029354
0.019569
0.027397
0.046967
0.039139
0.037182
0.048924
0.029354
0.035225
0.033268
0.011742
0.001957
0.005871
0.001957
0.009785
0.021526
0.039139
0.017613
0.015656
0.013699
0.027397
0.019569
0.058708
0.054795
1
2,726
T
A
A
G
T
G
A
T
C
C
T
T
G
G
C
A
A
T
G
T
A
A
A
C
A
G
C
C
A
C
T
C
T
G
G
T
T
T
T
T
C
C
A
C
T
C
C
C
T
G
T
A
G
G
G
A
G
G
C
A
G
A
T
G
A
C
0.084149
0.037182
0.062622
0.043053
0.04501
0.013699
0.003914
0.029354
0.050881
0.031311
0.035225
0.043053
0.027397
0.041096
0.041096
0.023483
0.033268
0.033268
0.013699
0.003914
0
0
0.019569
0.031311
0.050881
0.013699
0.017613
0.029354
0.029354
0.017613
0.050881
0.043053
1
2,727
G
G
A
A
G
G
G
A
A
G
A
A
T
A
T
C
A
T
C
A
T
C
T
G
C
C
T
C
C
C
T
A
C
A
G
G
G
A
G
T
G
G
A
A
A
A
A
C
C
A
G
A
G
T
G
G
C
T
G
T
T
T
A
C
A
T
0.091977
0.037182
0.064579
0.04501
0.043053
0.011742
0.003914
0.029354
0.054795
0.031311
0.033268
0.033268
0.02544
0.041096
0.041096
0.023483
0.035225
0.033268
0.013699
0.003914
0
0
0.015656
0.033268
0.056751
0.013699
0.017613
0.029354
0.029354
0.013699
0.048924
0.04501
1
2,728
G
G
A
A
G
G
G
A
A
G
A
A
T
A
T
C
A
T
C
A
T
C
T
G
C
C
T
C
C
C
T
A
C
A
G
G
G
A
G
T
G
G
A
A
A
A
A
C
C
A
G
A
G
T
G
G
C
T
G
T
T
T
A
C
A
G
0.091977
0.037182
0.064579
0.04501
0.043053
0.011742
0.003914
0.029354
0.054795
0.031311
0.033268
0.033268
0.02544
0.041096
0.041096
0.023483
0.035225
0.033268
0.013699
0.003914
0
0
0.015656
0.033268
0.056751
0.013699
0.017613
0.029354
0.029354
0.013699
0.048924
0.04501
1
2,729
T
G
G
G
G
G
C
C
C
T
G
A
T
C
C
A
G
T
C
G
G
T
A
A
A
G
A
A
G
C
T
T
T
C
T
G
A
T
G
T
G
A
T
G
A
T
C
C
T
G
A
C
T
G
T
G
T
T
C
T
G
T
C
T
G
C
0.050881
0.033268
0.037182
0.060665
0.056751
0.019569
0.001957
0.027397
0.043053
0.033268
0.023483
0.02544
0.037182
0.056751
0.037182
0.033268
0.048924
0.039139
0.027397
0.001957
0.003914
0.003914
0.017613
0.023483
0.04501
0.017613
0.031311
0.017613
0.027397
0.019569
0.048924
0.048924
1
2,730
T
G
T
G
G
G
G
G
C
C
C
T
G
A
T
C
C
A
G
T
C
G
G
T
A
A
A
G
A
A
G
C
T
T
T
C
T
G
A
T
G
T
G
A
T
G
A
T
C
C
T
G
A
C
T
G
T
G
T
T
C
T
G
T
C
C
0.052838
0.033268
0.037182
0.060665
0.056751
0.019569
0.001957
0.02544
0.043053
0.033268
0.023483
0.02544
0.037182
0.056751
0.037182
0.033268
0.048924
0.039139
0.027397
0.001957
0.003914
0.003914
0.015656
0.023483
0.04501
0.017613
0.031311
0.017613
0.027397
0.019569
0.050881
0.048924
1
2,731
A
C
G
A
T
A
T
T
C
T
A
C
T
T
T
A
T
T
C
A
A
T
A
T
G
C
T
C
A
T
T
A
T
G
T
G
C
A
C
G
A
T
T
C
T
T
A
C
C
A
A
C
T
G
T
G
T
A
T
T
T
A
T
G
A
G
0.082192
0.029354
0.052838
0.066536
0.037182
0.029354
0.003914
0.039139
0.033268
0.027397
0.031311
0.058708
0.015656
0.043053
0.050881
0.027397
0.017613
0.027397
0.009785
0
0.003914
0
0.037182
0.023483
0.037182
0.02544
0.02544
0.013699
0.015656
0.02544
0.060665
0.048924
1
2,732
G
C
A
A
A
A
G
T
A
A
T
G
A
C
T
G
T
G
A
A
A
T
C
C
A
A
C
C
A
A
T
T
C
C
A
T
G
G
A
T
C
C
C
G
T
A
A
A
A
A
T
G
T
G
A
A
A
T
C
T
T
C
T
A
A
A
0.105675
0.02544
0.054795
0.07045
0.031311
0.021526
0.005871
0.043053
0.033268
0.021526
0.023483
0.052838
0.031311
0.029354
0.04501
0.021526
0.019569
0.041096
0.019569
0.001957
0.001957
0.001957
0.033268
0.013699
0.037182
0.013699
0.013699
0.013699
0.031311
0.041096
0.07045
0.029354
1
2,733
G
A
G
A
A
C
T
C
T
G
A
A
T
G
T
T
C
T
C
A
A
C
G
C
T
G
A
G
A
C
A
T
T
G
C
C
C
A
G
G
T
C
C
A
C
A
A
A
C
T
C
T
G
T
C
A
C
A
T
A
T
C
T
G
T
C
0.084149
0.043053
0.037182
0.064579
0.058708
0.02544
0.003914
0.02544
0.050881
0.037182
0.027397
0.033268
0.017613
0.027397
0.050881
0.027397
0.041096
0.021526
0.013699
0.003914
0.009785
0.001957
0.031311
0.031311
0.054795
0.013699
0.027397
0.011742
0.015656
0.029354
0.039139
0.039139
1
2,734
G
A
C
T
G
A
A
A
T
T
G
T
T
T
T
C
A
A
T
G
C
T
C
G
G
A
G
A
A
C
T
C
T
G
A
A
T
G
T
T
C
T
C
A
A
C
G
C
T
G
A
G
A
C
A
T
T
G
C
C
C
A
G
G
T
C
0.084149
0.046967
0.041096
0.056751
0.062622
0.02544
0.003914
0.027397
0.046967
0.039139
0.027397
0.031311
0.017613
0.027397
0.054795
0.029354
0.041096
0.021526
0.011742
0.003914
0.009785
0.001957
0.029354
0.031311
0.048924
0.013699
0.027397
0.013699
0.013699
0.029354
0.039139
0.041096
1
2,735
C
C
C
C
C
T
T
C
T
G
A
T
T
T
T
G
T
T
T
G
T
A
G
G
C
C
T
G
A
A
G
A
C
C
A
T
T
G
T
G
G
G
G
G
C
C
C
T
G
A
T
C
C
A
G
T
C
A
G
T
G
A
A
G
A
G
0.080235
0.037182
0.033268
0.078278
0.046967
0.011742
0.003914
0.027397
0.02544
0.027397
0.023483
0.048924
0.02544
0.058708
0.048924
0.019569
0.037182
0.031311
0.019569
0.003914
0.001957
0.005871
0.02544
0.009785
0.064579
0.015656
0.02544
0.019569
0.027397
0.019569
0.035225
0.060665
1
2,736
A
T
C
A
G
A
A
A
G
C
T
T
C
T
T
C
A
C
T
G
A
C
T
G
G
A
T
C
A
G
G
G
C
C
C
C
C
A
C
A
A
T
G
G
T
C
T
T
C
A
G
G
C
C
T
A
C
A
A
A
C
A
A
A
A
A
0.080235
0.035225
0.035225
0.076321
0.04501
0.011742
0.003914
0.029354
0.02544
0.027397
0.02544
0.048924
0.027397
0.058708
0.046967
0.019569
0.037182
0.029354
0.019569
0.003914
0.001957
0.005871
0.02544
0.009785
0.062622
0.015656
0.02544
0.019569
0.027397
0.019569
0.039139
0.060665
1
2,737
C
C
T
G
A
T
C
C
A
G
T
C
A
G
T
G
A
A
G
A
A
G
C
T
T
T
C
T
G
A
T
G
T
C
A
T
G
A
T
C
T
T
G
A
C
T
G
T
G
T
T
C
T
G
T
C
T
A
A
G
C
G
T
G
T
C
0.076321
0.039139
0.039139
0.07045
0.043053
0.011742
0.003914
0.033268
0.027397
0.027397
0.02544
0.058708
0.029354
0.052838
0.046967
0.015656
0.035225
0.027397
0.019569
0.003914
0.001957
0.005871
0.027397
0.011742
0.056751
0.015656
0.02544
0.019569
0.02544
0.021526
0.04501
0.056751
1
2,738
A
A
A
C
A
C
G
C
T
T
A
G
A
C
A
G
A
A
C
A
C
A
G
T
C
A
A
G
A
T
C
A
T
G
A
C
A
T
C
A
G
A
A
A
G
C
T
T
C
T
T
C
A
C
T
G
A
C
T
G
G
A
T
C
A
C
0.076321
0.039139
0.039139
0.07045
0.043053
0.011742
0.003914
0.033268
0.029354
0.027397
0.02544
0.058708
0.029354
0.052838
0.046967
0.015656
0.035225
0.027397
0.019569
0.003914
0.001957
0.005871
0.027397
0.013699
0.054795
0.015656
0.02544
0.019569
0.02544
0.021526
0.04501
0.054795
1
2,739
C
A
T
G
A
A
C
A
A
C
T
G
C
A
A
T
C
C
T
A
T
T
A
G
C
G
C
A
A
A
C
A
C
G
C
T
T
A
G
A
C
A
G
A
A
C
A
C
A
G
T
C
A
A
G
A
T
C
A
T
G
A
C
A
T
T
0.074364
0.035225
0.035225
0.076321
0.039139
0.011742
0.003914
0.031311
0.029354
0.02544
0.02544
0.076321
0.029354
0.048924
0.04501
0.015656
0.033268
0.029354
0.019569
0.003914
0.001957
0.005871
0.029354
0.013699
0.048924
0.015656
0.023483
0.019569
0.027397
0.019569
0.054795
0.050881
1
2,740
C
A
T
G
A
A
C
A
A
C
T
G
C
A
A
T
C
C
T
A
T
T
A
G
C
G
C
A
A
A
C
A
C
G
C
T
T
A
G
A
C
A
G
A
A
C
A
C
A
G
T
C
A
A
G
A
T
C
A
T
G
A
C
A
T
A
0.074364
0.035225
0.035225
0.076321
0.039139
0.011742
0.003914
0.031311
0.029354
0.02544
0.02544
0.076321
0.029354
0.048924
0.04501
0.015656
0.033268
0.029354
0.019569
0.003914
0.001957
0.005871
0.029354
0.013699
0.048924
0.015656
0.023483
0.019569
0.027397
0.019569
0.054795
0.050881
1
2,741
G
T
T
G
C
C
C
A
T
G
A
A
C
A
A
C
T
G
C
A
A
T
C
C
T
A
T
T
A
G
C
G
C
A
A
A
C
A
C
G
C
T
T
A
G
A
C
A
G
A
A
C
A
C
A
G
T
C
A
A
G
A
T
C
A
T
0.076321
0.035225
0.035225
0.080235
0.039139
0.009785
0.003914
0.031311
0.029354
0.02544
0.02544
0.078278
0.029354
0.048924
0.04501
0.013699
0.031311
0.027397
0.019569
0.003914
0.001957
0.005871
0.029354
0.013699
0.048924
0.015656
0.023483
0.019569
0.027397
0.019569
0.056751
0.048924
1
2,742
G
A
T
C
T
T
G
A
C
T
G
T
G
T
T
C
T
G
T
C
T
A
A
G
C
G
T
G
T
T
T
G
C
G
C
T
A
A
T
A
G
G
A
T
T
G
C
A
G
T
T
G
T
T
C
A
T
G
G
G
C
A
A
C
C
T
0.076321
0.035225
0.035225
0.080235
0.039139
0.009785
0.003914
0.031311
0.029354
0.023483
0.02544
0.078278
0.031311
0.048924
0.04501
0.013699
0.031311
0.027397
0.019569
0.003914
0.001957
0.005871
0.029354
0.013699
0.048924
0.015656
0.023483
0.019569
0.027397
0.019569
0.056751
0.048924
1
2,743
T
G
C
A
A
A
C
A
T
T
T
A
T
T
T
C
G
T
A
G
G
T
T
G
C
C
C
A
T
G
A
A
C
A
A
C
T
G
C
A
A
T
C
C
T
A
T
T
A
G
C
G
C
A
A
A
C
A
C
G
C
T
T
A
G
A
0.072407
0.035225
0.033268
0.086106
0.041096
0.009785
0.003914
0.031311
0.033268
0.017613
0.023483
0.078278
0.035225
0.046967
0.046967
0.015656
0.029354
0.027397
0.019569
0.003914
0.001957
0.005871
0.027397
0.015656
0.046967
0.015656
0.021526
0.017613
0.027397
0.019569
0.058708
0.050881
1
2,744
A
A
A
C
T
C
A
G
T
A
G
G
A
A
G
C
A
T
C
A
C
T
T
A
C
C
C
T
G
C
A
T
C
T
G
A
G
C
T
G
T
T
G
C
C
A
C
A
A
A
G
C
A
G
A
G
C
A
T
C
A
T
T
T
T
G
0.088063
0.023483
0.027397
0.066536
0.035225
0.021526
0.001957
0.039139
0.041096
0.02544
0.029354
0.058708
0.033268
0.037182
0.033268
0.04501
0.033268
0.029354
0.013699
0.001957
0
0
0.033268
0.041096
0.037182
0.013699
0.027397
0.013699
0.02544
0.015656
0.048924
0.058708
1
2,745
A
A
A
C
T
C
A
G
T
A
G
G
A
A
G
C
A
T
C
A
C
T
T
A
C
C
C
T
G
C
A
T
C
T
G
A
G
C
T
G
T
T
G
C
C
A
C
A
A
A
G
C
A
G
A
G
C
A
T
C
A
T
T
T
T
A
0.088063
0.023483
0.027397
0.066536
0.035225
0.021526
0.001957
0.039139
0.041096
0.02544
0.029354
0.058708
0.033268
0.037182
0.033268
0.04501
0.033268
0.029354
0.013699
0.001957
0
0
0.033268
0.041096
0.037182
0.013699
0.027397
0.013699
0.02544
0.015656
0.048924
0.058708
1
2,746
G
A
A
A
C
T
C
A
G
T
A
G
G
A
A
G
C
A
T
C
A
C
T
T
A
C
C
C
T
G
C
A
T
C
T
G
A
G
C
T
G
T
T
G
C
C
A
C
A
A
A
G
C
A
G
A
G
C
A
T
C
A
T
T
T
A
0.088063
0.023483
0.027397
0.068493
0.035225
0.021526
0.001957
0.039139
0.041096
0.02544
0.029354
0.058708
0.033268
0.037182
0.033268
0.04501
0.033268
0.029354
0.013699
0.001957
0
0
0.033268
0.041096
0.037182
0.013699
0.02544
0.013699
0.02544
0.015656
0.048924
0.058708
1