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E-nergEYEze, a vision-specific eHealth intervention based on cognitive behavioral therapy and self-management to reduce fatigue in adults with visual impairment: study protocol for a randomized controlled trial. | BACKGROUND
More than half of the adults with visual impairment experience severe symptoms of fatigue, with a negative impact on daily life. Since there is no evidence-based treatment to reduce fatigue in adults with visual impairment, we developed E-nergEYEze, an eHealth intervention based on cognitive behavioral thera... | 10.1186/s13063-021-05935-w | 34,963,472 | D000328:Adult; D015928:Cognitive Behavioral Therapy; D003362:Cost-Benefit Analysis; D005221:Fatigue; D006801:Humans; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D000073278:Self-Management; D017216:Telemedicine; D016896:Treatment Outcome; D014786:Vision Disorders; D015354:Vision, Low | Trials | 2,021 | |
Future Anxiety Among Young People Affected by War and Armed Conflict: Indicators for Social Work Practice. | Strengthening the evidence base for professional social work intervention that contributes to providing psychosocial support to international students affected by war and conflict is a major priority as this vulnerable group of youth increases. Therefore, this study aimed to determine the level of future anxiety among ... | 10.3389/fsoc.2021.729811 | 34,912,879 | Frontiers in sociology | 2,021 | ||
Trends in neonatal mortality and morbidity in very-low-birth-weight (VLBW) infants over a decade: Singapore national cohort study. | BACKGROUND
Very preterm infants are at risk for neurodevelopmental impairment because of postnatal morbidities. This study aims to (1) compare the outcomes of very-low-birth-weight (VLBW) infants in Singapore during two time periods over a decade; 2) compare performances among Singaporean neonatal intensive care units ... | 10.1016/j.pedneo.2022.12.016 | 36,967,293 | D007231:Infant, Newborn; D007223:Infant; D006801:Humans; D005260:Female; D011247:Pregnancy; D015331:Cohort Studies; D007234:Infant, Premature; D012846:Singapore; D001315:Australia; D019102:Infant, Very Low Birth Weight; D007226:Infant Mortality; D009017:Morbidity; D018805:Sepsis | Pediatrics and neonatology | 2,023 | |
Pharmacologic considerations in the management of temporomandibular disorders. | The management of patients with temporomandibular disorders may involve the use of a number of modalities, including pharmacotherapy. This manuscript provides an overview of the pharmacology of agents currently employed for this purpose, with an emphasis on the major drug group used, the non-steroidal anti-inflammatory... | 7,600,411 | D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D014151:Anti-Anxiety Agents; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000929:Antidepressive Agents, Tricyclic; D001569:Benzodiazepines; D000075202:Contraindications; D006801:Humans; D009125:Muscle Relaxants, Central; D015... | Journal (Canadian Dental Association) | 1,995 | D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D014151:Anti-Anxiety Agents; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000929:Antidepressive Agents, Tricyclic; D009125:Muscle Relaxants, Central; D013256:Steroids; D001569:Benzodiazepines | |
Neurochemical characterization of an antimony-choline analog in rat cortical synaptosomes. | An analog of choline, in which nitrogen was replaced by antimony, was neurochemically characterized in rat cortical synaptosomes. It was found to be a substrate for several cholinergic enzymes, transported by a Na+-dependent, hemicholinium-3-sensitive process, acetylated, and subsequently released by depolarization in ... | 10.1111/j.1471-4159.1982.tb03950.x | 7,045,287 | D000105:Acetyl Coenzyme A; D000107:Acetylation; D000818:Animals; D000965:Antimony; D002540:Cerebral Cortex; D002794:Choline; D002797:Choline Kinase; D002795:Choline O-Acetyltransferase; D006426:Hemicholinium 3; D008297:Male; D009942:Organometallic Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D012441:Saccharom... | Journal of neurochemistry | 1,982 | D009942:Organometallic Compounds; D006426:Hemicholinium 3; D000105:Acetyl Coenzyme A; C033204:antimony choline; D000965:Antimony; D012964:Sodium; D002795:Choline O-Acetyltransferase; D002797:Choline Kinase; D002794:Choline |
[The acute Achilles tendon rupture: new insights in the treatment]. | The acute Achilles tendon rupture is a typical sports injury, which most commonly occurs in men. The diagnosis is easy to make but there is no consensus on best treatment: surgical or conservative treatment? In the case of surgical repair, the risk of a re-rupture is considerably smaller compared to conservative treatm... | 19,785,867 | D000125:Achilles Tendon; D002370:Casts, Surgical; D006801:Humans; D007103:Immobilization; D011183:Postoperative Complications; D012307:Risk Factors; D012421:Rupture; D013708:Tendon Injuries; D016896:Treatment Outcome | Nederlands tijdschrift voor geneeskunde | 2,009 | ||
Polyphyllin VII protects from breast cancer-induced osteolysis by suppressing osteoclastogenesis via c-Fos/NFATc1 signaling. | Bone is a preferred metastatic site of advanced breast cancer and the 5-year overall survival rate of breast cancer patients with bone metastasis is only 22.8%. Targeted inhibition of osteoclasts can treat skeletal-related events (SREs) in breast cancer patients. Polyphyllin VII (PP7), a pennogenyl saponin isolated fro... | 10.1016/j.intimp.2023.110316 | 37,253,315 | D000818:Animals; D051379:Mice; D010012:Osteogenesis; D010014:Osteolysis; D010010:Osteoclasts; D012503:Saponins; D016760:Proto-Oncogene Proteins c-fos; D001862:Bone Resorption; D053245:RANK Ligand; D002454:Cell Differentiation; D009369:Neoplasms | International immunopharmacology | 2,023 | C585643:polyphyllin VII; D012503:Saponins; D016760:Proto-Oncogene Proteins c-fos; D053245:RANK Ligand |
Cardiac rhythm during temporal lobe seizures. | We studied the neuroanatomic correlates of ictal tachycardia in 27 seizures from five patients with unilateral temporal lobe epilepsy being evaluated with bilateral temporal lobe depth electrodes and orbitofrontal subdural electrodes. There were 11 complex partial seizures, three simple partial seizures, and 13 subclin... | 10.1212/wnl.42.1.50 | 1,734,323 | D000328:Adult; D004569:Electroencephalography; D004828:Epilepsies, Partial; D017029:Epilepsy, Complex Partial; D004833:Epilepsy, Temporal Lobe; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male | Neurology | 1,992 | |
The molecular mechanism of insulin action. | Insulin initiates its action by binding to a glycoprotein receptor on the surface of the cell. This receptor consists of an alpha-subunit, which binds the hormone, and a beta-subunit, which is an insulin-stimulated, tyrosine-specific protein kinase. Activation of this kinase is believed to generate a signal that eventu... | 10.1146/annurev.me.36.020185.002241 | 2,986,528 | D000052:Acanthosis Nigricans; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D007328:Insulin; D007333:Insulin Resistance; D010455:Peptides; D011494:Protein Kinases; D011972:Receptor, Insulin; D011956:Receptors, Cell Surface; D017451:Receptors, Somatomedin; D013002:Somatomedins | Annual review of medicine | 1,985 | D007328:Insulin; D010455:Peptides; D011956:Receptors, Cell Surface; D017451:Receptors, Somatomedin; D013002:Somatomedins; D011494:Protein Kinases; D011972:Receptor, Insulin |
Duodenal ulcer healing by separate reduction of postprandial and nocturnal acid secretions have different pathophysiology. | The endoscopic healing rates and factors related to healing of two cimetidine regimens designed to reduce respectively postprandial and nocturnal acid secretions were studied in a randomised trial of cimetidine 200 mg tds with meals, vs 600 mg at bedtime, vs 200 mg tds with meals plus 400 mg at bedtime in 246 patients ... | 10.1136/gut.26.10.1038 | 4,054,701 | D000328:Adult; D000700:Analgesics; D002927:Cimetidine; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer; D005260:Female; D005744:Gastric Acid; D005755:Gastrins; D006801:Humans; D008297:Male; D012907:Smoking; D014945:Wound Healing | Gut | 1,985 | D000700:Analgesics; D005755:Gastrins; D002927:Cimetidine |
[In situ hybridization--an expansion of dermatologic histopathology]. | By means of in-situ-hybridization, we are able to detect specifically the mRNAs of defined proteins at a cellular level in frozen sections. This technique not only makes it possible to characterize the biosynthesis of defined proteins at a pretranslational level but can also identify activated cells in their histologic... | 3,043,951 | D001483:Base Sequence; D001706:Biopsy; D003001:Cloning, Molecular; D004247:DNA; D006801:Humans; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger; D012594:Scleroderma, Localized; D012867:Skin; D012871:Skin Diseases | Zeitschrift fur Hautkrankheiten | 1,988 | D012333:RNA, Messenger; D004247:DNA | |
Studies on anterograde trophic interactions based on general muscle properties. | General properties of rat skeletal muscle (extrajunctional membrane and contractile properties) are subjected to tight physiological neural regulation, as indicated by their striking alterations (up- or down-regulation) following denervation. The main contributions of the literature concerning the nature of the neural ... | 9,270,895 | D000818:Animals; D015536:Down-Regulation; D009119:Muscle Contraction; D009121:Muscle Denervation; D018482:Muscle, Skeletal; D009414:Nerve Growth Factors; D051381:Rats; D011950:Receptors, Cholinergic; D015854:Up-Regulation | Archives italiennes de biologie | 1,997 | D009414:Nerve Growth Factors; D011950:Receptors, Cholinergic | |
Endogenous dopaminergic modulation of the lamprey spinal locomotor network. | The lamprey spinal cord contains three dopaminergic systems. The most extensive is the ventromedial plexus in which dopamine is co-localized with 5-HT and tachykinins. In this study we have investigated the effects of endogenously released dopamine on NMDA-induced spinal activity, and for comparison applied dopamine ex... | 10.1016/s0006-8993(02)04216-6 | 12,706,243 | D000818:Animals; D004298:Dopamine; D018765:Dopamine Uptake Inhibitors; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007798:Lampreys; D008124:Locomotion; D016202:N-Methylaspartate; D009415:Nerve Net; D013116:Spinal Cord | Brain research | 2,003 | D018765:Dopamine Uptake Inhibitors; D016202:N-Methylaspartate; D004298:Dopamine |
Effects of short-chain nitrocompounds against Campylobacter jejuni and Campylobacter coli in vitro. | Effects of 2-nitro-1-propanol, 2-nitroethanol, nitroethane, and 2-nitro-methyl-propionate (0, 10, and 20 mM) on growth of Campylobacter jejuni were tested during culture in Bolton broth adjusted to pH 5.6, 7.0, or 8.2. The nitrocompounds were similarly tested against C. coli but at pH 8.2 only. Viable cell counts measu... | 10.1111/j.1750-3841.2006.00255.x | 17,995,842 | D019540:Area Under Curve; D017000:Campylobacter coli; D016123:Campylobacter jejuni; D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D004980:Ethane; D005511:Food Handling; D005516:Food Microbiology; D005519:Food Preservation; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008826:Microb... | Journal of food science | 2,007 | C496417:2-nitropropanol; D009574:Nitro Compounds; D020005:Propanols; D004980:Ethane |
Anterolateral mini-invasive versus posterior mini-invasive approach for primary total hip replacement. Comparison of exposure and implant positioning. | INTRODUCTION
We conducted a prospective study to compare the exposure and implant positioning in primary total hip replacement through the anterolateral minimally invasive (ALMI) approach versus the posterior minimally invasive (PMI) approach.
MATERIALS AND METHODS
We applied these techniques to 2 consecutive groups ... | 10.1007/s00402-007-0385-9 | 17,639,434 | D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip; D010024:Osteoporosis; D011446:Prospective Studies | Archives of orthopaedic and trauma surgery | 2,008 | |
Assay of somatomedin C by cartridge extraction prior to radioimmunoassay with antiserum developed against synthetic somatomedin C. | The whole molecule of human somatomedin C (SM-C) prepared by the total synthesis method was used as an antigen to produce an antiserum for a radioimmunoassay. Since plasma proteins that bind SM-C interfere with the assay, a method was developed that uses acid dissociation followed by C-2 cartridge extraction to strip S... | 2,454,603 | D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002352:Carrier Proteins; D002648:Child; D002675:Child, Preschool; D002850:Chromatography, Gel; D003429:Cross Reactions; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007106:Immune Sera; D007223:Infant; D018969:Insulin-Like Growth Factor Bin... | Annals of clinical and laboratory science | 1,988 | D002352:Carrier Proteins; D007106:Immune Sera; D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D011384:Proinsulin | |
Visible Human 2.0--the next generation. | The National Library of Medicine has initiated the development of new anatomical methods and techniques for the acquisition of higher resolution data sets, aiming to address the anatomical artifacts encountered in the development of the Visible Human Male and Female and to insure enhanced detection of structures, provi... | 15,455,907 | D003198:Computer Simulation; D005260:Female; D018594:Human Body; D006801:Humans; D008297:Male; D009317:National Library of Medicine (U.S.); D012984:Software; D014481:United States | Studies in health technology and informatics | 2,003 | ||
[Efficient expression of human papillomavirus type 16 (HPV16) capsid proteins L1 and L2 in E. coli]. | OBJECTIVE
To study the expression of HPV16 capsid proteins L1 and L2 in E. coli.
METHODS
The plasmids pET-30a-L1 and pET-30a-L2 were constructed from the pET-30a vector, and transducted into the BL21. The fusion proteins 6 x His-L1 and 6 x His-L2 were expressed when induced by adding of IPTG. SDS-PAGE and Western blo... | 12,759,977 | D036022:Capsid Proteins; D004926:Escherichia coli; D009856:Oncogene Proteins, Viral; D027383:Papillomaviridae; D010957:Plasmids; D014162:Transfection | Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology | 1,999 | D036022:Capsid Proteins; C063316:L2 protein, Human papillomavirus type 16; D009856:Oncogene Proteins, Viral; C063317:L1 protein, Human papillomavirus type 16 | |
[Coding in neuropediatrics based on the International Classification Diseases, 9th revision (ICD-9), 5th edition (2006)]. | AIMS
To analyze International Classification Diseases, 9th revision (ICD-9) coding and adapt it, on a consensus basis, to 'reasons for medical consultation', 'diagnoses' and 'procedures' in child neurology.
MATERIALS AND METHODS
The most frequent reasons for medical consultation, diagnoses and procedures in neuropedi... | 19,173,201 | D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003953:Diagnosis-Related Groups; D019468:Disease Management; D006786:Hospitals, Urban; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D038801:International Classification of Diseases; D009422:Nervous System Diseases; D009462:Neurology; D010372:Pedi... | Revista de neurologia | 2,009 | ||
Correlation between Patent Foramen Ovale, Cerebral "Lesions" and Neuropsychometric Testing in Experienced Sports Divers: Does Diving Damage the Brain? | SCUBA diving exposes divers to decompression sickness (DCS). There has been considerable debate whether divers with a Patent Foramen Ovale of the heart have a higher risk of DCS because of the possible right-to-left shunt of venous decompression bubbles into the arterial circulation. Symptomatic neurological DCS has be... | 10.3389/fpsyg.2016.00696 | 27,242,609 | Frontiers in psychology | 2,016 | ||
Gaius Caligula's mental illness. | The strange behavior of emperor Gaius has been the subject of debate for many historians. Some charge him with madness and attribute it to his illness in A.D. 37, whereas others believe it occurred later, or else had nothing to do with his sickness.We have no real evidence to reconstruct his mental state. Therefore spe... | 10.1353/clw.0.0165 | 20,213,971 | D004827:Epilepsy; D049690:History, Ancient; D016743:Mental Competency; D001523:Mental Disorders; D018644:Roman World | Classical world | 2,010 | |
Generation of 4-dimensional CT images based on 4-dimensional PET-derived motion fields. | UNLABELLED
Respiratory motion can potentially reduce accuracy in anatomic and functional image fusion from multimodality systems. It can blur the uptake of small lesions and lead to significant activity underestimation. Solutions presented to date include respiration-synchronized anatomic and functional acquisitions. T... | 10.2967/jnumed.112.110809 | 23,471,313 | D000465:Algorithms; D016477:Artifacts; D056973:Four-Dimensional Computed Tomography; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009010:Monte Carlo Method; D009068:Movement; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography; D012119:Respiration | Journal of nuclear medicine : official publication, Society of Nuclear Medicine | 2,013 | |
The re-emergence of the minimal running shoe. | The running shoe has gone through significant changes since its inception. The purpose of this paper is to review these changes, the majority of which have occurred over the past 50 years. Running footwear began as very minimal, then evolved to become highly cushioned and supportive. However, over the past 5 years, the... | 10.2519/jospt.2014.5521 | 25,211,531 | D001265:Athletic Injuries; D001696:Biomechanical Phenomena; D004867:Equipment Design; D005528:Foot; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D049690:History, Ancient; D006801:Humans; D012420:Running; D012775:Shoes | The Journal of orthopaedic and sports physical therapy | 2,014 | |
[Clinicians' opinion of pregraduate teaching of anatomy]. | Work deals with the evaluation of a questionnaire given to 110 young clinicians at the teaching hospital of School of Medicine in Hradec Králové asking questions concerning their opinion of the pregraduate teaching of anatomy; 97 of them answered. This yielded a response rate 96%. The results were analysed by customary... | 19,569,585 | D000715:Anatomy; D001291:Attitude of Health Personnel; D003479:Curriculum; D018153:Czech Republic; D003625:Data Collection; D004504:Education, Medical, Undergraduate; D006801:Humans | Acta medica (Hradec Kralove). Supplementum | 2,002 | ||
Evaluation of hepatic function using dynamic contrast-enhanced magnetic resonance imaging in melanocortin 4 receptor-deficient mice as a model of nonalcoholic steatohepatitis. | INTRODUCTION
Melanocortin 4 receptor-deficient (MC4R-KO) mice fed a high-fat diet (HFD) develop liver pathology similar to human nonalcoholic steatohepatitis (NASH). However, although liver histology and blood biochemistry have been reported, hepatic function has not been evaluated. In the present study, we evaluated h... | 10.1016/j.mri.2018.11.013 | 30,465,867 | D000818:Animals; D003287:Contrast Media; D004195:Disease Models, Animal; D019786:Gadolinium DTPA; D007089:Image Enhancement; D008099:Liver; D008279:Magnetic Resonance Imaging; D051379:Mice; D065626:Non-alcoholic Fatty Liver Disease; D044105:Receptor, Melanocortin, Type 4 | Magnetic resonance imaging | 2,019 | D003287:Contrast Media; D044105:Receptor, Melanocortin, Type 4; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA |
Anopheles sundaicus complex and the presence of Anopheles epiroticus in Indonesia. | Anopheles sundaicus s.l. is an important malaria vector primarily found in coastal landscapes of western and central Indonesia. The species complex has a wide geographical distribution in South and Southeast Asia and exhibits ecological and behavioural variability over its range. Studies on understanding the distributi... | 10.1371/journal.pntd.0008385 | 32,614,914 | D000818:Animals; D000852:Anopheles; D045303:Cytochromes b; D003710:Demography; D003576:Electron Transport Complex IV; D005260:Female; D006801:Humans; D007214:Indonesia; D008288:Malaria; D000072138:Mosquito Vectors; D010802:Phylogeny | PLoS neglected tropical diseases | 2,020 | D045303:Cytochromes b; D003576:Electron Transport Complex IV |
Biased selection of leading process branches mediates chemotaxis during tangential neuronal migration. | Current models of chemotaxis during neuronal migration and axon guidance propose that directional sensing relies on growth cone dynamics. According to this view, migrating neurons and growing axons are guided to their correct targets by steering the growth cone in response to attractive and repulsive cues. Here, we hav... | 10.1242/dev.025502 | 19,060,332 | D000577:Amides; D000818:Animals; D019556:COS Cells; D022081:Cell Surface Extensions; D002490:Central Nervous System; D002633:Chemotaxis; D002522:Chlorocebus aethiops; D007395:Interneurons; D051379:Mice; D009419:Nerve Tissue Proteins; D020890:Neuregulin-1; D009474:Neurons; D011725:Pyridines; D012641:Selection, Genetic | Development (Cambridge, England) | 2,009 | D000577:Amides; D009419:Nerve Tissue Proteins; D020890:Neuregulin-1; C490581:Nrg1 protein, mouse; D011725:Pyridines; C108830:Y 27632 |
Stability in vitro of the 69K movement protein of Turnip yellow mosaic virus is regulated by the ubiquitin-mediated proteasome pathway. | Plant viruses move to adjacent cells with the use of virus-encoded cell-to-cell movement proteins. Using proteins produced by in vitro translation, we present evidence that the '69K' movement protein of Turnip yellow mosaic virus (TYMV) is recognized as a substrate for the attachment of polyubiquitin chains and for sub... | 10.1099/0022-1317-83-12-3187 | 12,466,497 | D000818:Animals; D029688:Brassica napus; D015967:Gene Expression Regulation, Viral; D010935:Plant Diseases; D053830:Plant Viral Movement Proteins; D010942:Plant Viruses; D014176:Protein Biosynthesis; D011817:Rabbits; D012156:Reticulocytes; D017806:Tymovirus; D025801:Ubiquitin; D014764:Viral Proteins | The Journal of general virology | 2,002 | D053830:Plant Viral Movement Proteins; D025801:Ubiquitin; D014764:Viral Proteins |
Effect of cigarette menthol content on mainstream smoke emissions. | The 2009 Family Smoking Prevention and Tobacco Control Act empowered the U.S. Food and Drug Administration to study "the impact of the use of menthol in cigarettes on the public health, including such use among children, African Americans, Hispanics and other racial and ethnic minorities," and develop recommendations. ... | 10.1021/tx200285s | 21,888,394 | D000393:Air Pollutants; D005421:Flavoring Agents; D013058:Mass Spectrometry; D008610:Menthol; D012907:Smoking; D014028:Tobacco Smoke Pollution; D055549:Volatile Organic Compounds | Chemical research in toxicology | 2,011 | D000393:Air Pollutants; D005421:Flavoring Agents; D014028:Tobacco Smoke Pollution; D055549:Volatile Organic Compounds; D008610:Menthol |
Pentacene Dimers as a Critical Tool for the Investigation of Intramolecular Singlet Fission. | Singlet fission (SF) involves the spontaneous splitting of a photoexcited singlet state into a pair of triplets, and it holds great promise toward the realization of more efficient solar cells. Although the process of SF has been known since the 1960s, debate regarding the underlying mechanism continues to this day, es... | 10.1002/chem.201705355 | 29,323,762 | Chemistry (Weinheim an der Bergstrasse, Germany) | 2,018 | ||
Comparison of the human-exosuit interaction using ankle moment and ankle positive power inspired walking assistance. | Previous ankle exoskeleton assistance techniques that were able to demonstrate metabolic reductions can be categorized into those that delivered moment profiles similar to the biological ankle moment throughout the stance phase, and others that delivered positive power only during push off. Both assistance techniques a... | 10.1016/j.jbiomech.2018.11.023 | 30,514,626 | D000328:Adult; D000842:Ankle; D001696:Biomechanical Phenomena; D004734:Energy Metabolism; D005081:Exercise Therapy; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D055595:Mechanical Phenomena; D012371:Robotics; D016138:Walking | Journal of biomechanics | 2,019 | |
Aedes larval bionomics and implications for dengue control in the paradigmatic Jaffna peninsula, northern Sri Lanka. | BACKGROUND
The larval bionomics of Aedes across the Jaffna peninsula in northern Sri Lanka was investigated to obtain information needed for developing more effective larval source reduction measures to control endemic arboviral diseases.
METHODS
The habitats of preimaginal stages of Aedes mosquitoes were surveyed, a... | 10.1186/s13071-021-04640-6 | 33,736,702 | D000330:Aedes; D000818:Animals; D003715:Dengue; D004463:Ecology; D017753:Ecosystem; D005260:Female; D007814:Larva; D000072138:Mosquito Vectors; D054712:Salinity; D013188:Sri Lanka | Parasites & vectors | 2,021 | |
Orchestration of carbohydrate processing for crassulacean acid metabolism. | The production of phosphoenolpyruvate as a substrate for nocturnal CO2 uptake represents a significant sink for carbohydrate in CAM plants which has to be balanced with the provisioning of carbohydrate for growth and maintenance. In starch-storing CAM species, diversification in chloroplast metabolite transporters, and... | 27,101,569 | D050260:Carbohydrate Metabolism; D002244:Carbon; D018745:Genome, Plant; D010788:Photosynthesis; D010944:Plants | Current opinion in plant biology | 2,016 | D002244:Carbon | |
The mammalian nodal action potential: new data bring new perspectives. | Since its discovery in the mid-20th century, the Hodgkin-Huxley biophysical model of the squid giant axon's (SGA's) neurophysiology has traditionally served as the basis for the teaching of action potential (AP) dynamics in the physiology classroom. This model teaches that leak conductances set membrane resting potenti... | 10.1152/advan.00171.2021 | 36,173,340 | D000818:Animals; D006801:Humans; D000200:Action Potentials; D024683:Potassium Channels, Tandem Pore Domain; D008564:Membrane Potentials; D024642:Potassium Channels, Voltage-Gated; D001369:Axons; D011188:Potassium; D008322:Mammals | Advances in physiology education | 2,022 | D024683:Potassium Channels, Tandem Pore Domain; D024642:Potassium Channels, Voltage-Gated; D011188:Potassium |
A proposed unified mitotic chromosome architecture. | A molecular architecture is proposed for a representative mitotic chromosome, human chromosome 10. This architecture is built on an interphase chromosome structure based on cryo-electron microscopy (cryo-EM) cellular tomography [J. Sedat et al., Proc. Natl. Acad. Sci. U.S.A., in press], thus unifying chromosome structu... | 10.1073/pnas.2119107119 | 35,544,689 | D002467:Cell Nucleus; D002879:Chromosomes, Human, Pair 10; D042003:DNA Packaging; D016193:G1 Phase; D006801:Humans; D008938:Mitosis; D009707:Nucleosomes; D016133:Polymerase Chain Reaction; D013601:T-Lymphocytes | Proceedings of the National Academy of Sciences of the United States of America | 2,022 | D009707:Nucleosomes |
Bader's Topological Bond Path Does Not Necessarily Indicate Stabilizing Interaction-Proof Studies Based on the Ng@[3n]cyclophane Endohedral Complexes. | According to Bader's quantum theory of atoms in molecules (QTAIM), the simultaneous presence of a bond path and the corresponding bond critical point between any two atoms is both a necessary and sufficient condition for the atoms to be bonded to one another. In principle, this means that this pair of atoms should make... | 10.3390/molecules28176353 | 37,687,183 | Molecules (Basel, Switzerland) | 2,023 | ||
Impact of Fermentation, Autoclaving and Phytase Treatment on the Antioxidant Properties and Quality of Teff Cookies. | Research background
Teff [Eragrostis tef (Zucc.) Trotter] is an underutilised cereal crop grown mainly in Ethiopia and Eritrea. It is an excellent source of dietary fibre, vitamins, minerals and bioactive compounds. However, it also contains a high amount of phytic acid, which is an antinutrient and reduces the bioavai... | 10.17113/ftb.61.03.23.8145 | 38,022,881 | Food technology and biotechnology | 2,023 | ||
Collection of data on race/ethnicity and language proficiency of providers. | OBJECTIVES
To determine the extent to which health plans were collecting and using data on the race, ethnicity, and language proficiency of network physicians and other network providers.
STUDY DESIGN
Survey of health plans conducted in 2010, with results compared with data from similar surveys conducted in 2006 and ... | 24,512,089 | D003625:Data Collection; D006282:Health Personnel; D006801:Humans; D007802:Language; D008329:Managed Care Programs; D044469:Racial Groups; D011795:Surveys and Questionnaires; D014481:United States | The American journal of managed care | 2,013 | ||
Guggul for hyperlipidemia: a review by the Natural Standard Research Collaboration. | OBJECTIVE
To evaluate the scientific evidence on guggul for hyperlipidemia including expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
METHODS
Electronic searches were conducted in nine databases, 20 additional journals (not indexed i... | 10.1016/j.ctim.2005.08.003 | 16,338,199 | D002986:Clinical Trials as Topic; D029744:Commiphora; D004347:Drug Interactions; D006801:Humans; D006949:Hyperlipidemias; D000960:Hypolipidemic Agents; D008515:Medicine, Ayurvedic; D010936:Plant Extracts; D053149:Plant Gums | Complementary therapies in medicine | 2,005 | D000960:Hypolipidemic Agents; D010936:Plant Extracts; D053149:Plant Gums; C018562:guggulu extract |
Viral antigens and impurities in influenza vaccines. Evaluation by immunoelectrophoretic methods. | Laurell electrophoretic methods were used to evaluate internal influenza virus antigens and immunogenic impurities (from the fertile egg) in influenza whole virus and subunit preparations. It could be found that subunit preparations obtained after selective solubilization of the surface antigens with cetyltrimethylammo... | 564,309 | D000818:Animals; D000914:Antibodies, Viral; D000956:Antigens, Viral; D002593:Cetrimonium Compounds; D002642:Chick Embryo; D004340:Drug Contamination; D004625:Embryo, Nonmammalian; D007122:Immunoelectrophoresis; D009980:Influenza A virus; D007252:Influenza Vaccines | Developments in biological standardization | 1,977 | D000914:Antibodies, Viral; D000956:Antigens, Viral; D002593:Cetrimonium Compounds; D007252:Influenza Vaccines | |
[A case of Rendu-Osler-Weber disease associated with pulmonary arteriovenous fistula]. | A 60-year-old female was admitted with a chief complaint of left hemothorax. Chest X-ray films revealed an abnormal shadow when the pleural effusion disappeared. On the physical examination, multiple telangiectases were found at the nasal mucosa, tongue and stomach. The family history showed that her son experienced fr... | 8,230,914 | D001164:Arteriovenous Fistula; D005260:Female; D006801:Humans; D008875:Middle Aged; D011651:Pulmonary Artery; D011667:Pulmonary Veins; D013683:Telangiectasia, Hereditary Hemorrhagic | Kyobu geka. The Japanese journal of thoracic surgery | 1,993 | ||
Dereplication of Streptomyces soil isolates and detection of specific biosynthetic genes using an automated ribotyping instrument. | The discrimination of distinct cultures among morphologically similar Streptomyces soil isolates (dereplication) and the detection of specific biosynthetic pathways in these strains are important steps in the selection of microorganisms to include in a natural products library. We have developed methods for analysis of... | 10.1007/s10295-003-0038-0 | 12,687,492 | D001709:Biotechnology; D016172:DNA Fingerprinting; D005227:Fatty Acids; D005285:Fermentation; D005798:Genes, Bacterial; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S; D021521:Ribotyping; D012988:Soil Microbiology; D013302:Streptomyces | Journal of industrial microbiology & biotechnology | 2,003 | D005227:Fatty Acids; D012336:RNA, Ribosomal, 16S |
Phonatory vocal tract stability in stuttering children before and after fluency--enhancing therapy. | BACKGROUND
Stuttering is a complex disorder. Essentially, it is a neuromuscular disorder whose core consists of tiny lags and disruptions in the timing of the complicated movements required for speech.
OBJECTIVE
The purpose of the current study was to collec and comparg jitters and shimmer values in children who stut... | 10.3126/kumj.v8i4.6240 | 22,610,770 | D002675:Child, Preschool; D005260:Female; D006801:Humans; D010699:Phonation; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013061:Speech Acoustics; D013068:Speech Production Measurement; D013070:Speech Therapy; D013342:Stuttering; D013997:Time Factors; D016896:Treatment Outcome; D014833:Voice ... | Kathmandu University medical journal (KUMJ) | 2,010 | |
Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. | BACKGROUND
Insulin resistance is present in the setting of congestive heart failure. Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin with both insulinotropic and insulinomimetic properties.
METHODS AND RESULTS
We investigated the safety and efficacy of a 5-week infusion of GLP-1 (2.5 pmol/kg/min) ad... | 10.1016/j.cardfail.2006.08.211 | 17,174,230 | D000368:Aged; D002303:Cardiac Output, Low; D002908:Chronic Disease; D048909:Diabetes Complications; D004334:Drug Administration Schedule; D005260:Female; D005767:Gastrointestinal Diseases; D052216:Glucagon-Like Peptide 1; D006321:Heart; D006801:Humans; D007003:Hypoglycemia; D007279:Injections, Subcutaneous; D008297:Mal... | Journal of cardiac failure | 2,006 | D052216:Glucagon-Like Peptide 1 |
The therapeutic effect of concurrent administration of 5-fluorouracil and allylestrenol or hexestrol in small doses on prostatic carcinoma. | A trial to reduce the dosage of estrogen or to substitute it by other agents was done as a treatment of prostatic carcinoma. Either the combination of 5-FU (200 mg/day) and allylestrenol (50 mg/day), or 5-FU and hexestrol (20 mg/day) was given to 24 cases of prostatic carcinoma, 4 of whom were relapsed hormonal-resista... | 10.1002/pros.2990020518 | 6,281,750 | D000368:Aged; D000500:Allylestrenol; D004359:Drug Therapy, Combination; D004963:Estrenes; D005472:Fluorouracil; D006589:Hexestrol; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms | The Prostate. Supplement | 1,981 | D004963:Estrenes; D006589:Hexestrol; D000500:Allylestrenol; D005472:Fluorouracil |
Tuberculosis of the middle ear and nasal passage: A case report. | The following report highlights the case of a 55-year-old female with nasal and middle ear tuberculosis. The diagnosis was confirmed using imagery, histopathological biopsy reports, and Polymerase chain reaction (TB-PCR). The patient was treated with rifampicin (10mg/kg), isoniazid (5mg/kg) and pyrazinamide (25mg/kg) f... | 26,785,789 | International journal of mycobacteriology | 2,013 | |||
Identification of nucleoid associated proteins (NAPs) under oxidative stress in Staphylococcus aureus. | BACKGROUND
Bacterial nucleoid consists of genome DNA, RNA, and hundreds of nucleoid-associated proteins (NAPs). Escherichia coli nucleoid is compacted towards the stationary phase, replacing most log-phase NAPs with the major stationary-phase nucleoid protein, Dps. In contrast, Staphylococcus aureus nucleoid sustains t... | 10.1186/s12866-017-1114-3 | 28,969,590 | D001426:Bacterial Proteins; D002853:Chromatography, Liquid; D004268:DNA-Binding Proteins; D018384:Oxidative Stress; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; D013211:Staphylococcus aureus; D053719:Tandem Mass Spectrometry | BMC microbiology | 2,017 | D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins |
Implication of RPA32 phosphorylation in S-phase checkpoint signalling at replication forks stalled with aphidicolin in Xenopus egg extracts. | Activation of the replication checkpoint relies upon uncoupling of DNA polymerases and helicase activities at replication forks, which in multicellular organism results in production of long stretches of single-stranded DNA bound by the trimeric, single stranded DNA binding protein, the RPA complex. Binding of RPA to t... | 23,047,005 | D000818:Animals; D002457:Cell Extracts; D002478:Cells, Cultured; D004261:DNA Replication; D009154:Mutation; D010063:Ovum; D010766:Phosphorylation; D051716:Replication Protein A; D059807:S Phase Cell Cycle Checkpoints; D015398:Signal Transduction; D014982:Xenopus laevis | Biochemical and biophysical research communications | 2,012 | D002457:Cell Extracts; D051716:Replication Protein A; C516794:RPA2 protein, human | |
Mucosal gastrin concentration, molecular forms of gastrin, number and ultrastructure of G-cells in patients with duodenal ulcer. | The mean antral immunoreactive gastrin (IRG) concentration of 38 duodenal ulcer (DU) patients was significantly higher (35-9+/-5-2 mug/g) than that of 21 controls (15-9+/-2-6 mug/g). Also the mean IRG concentration in the proximal duodenal mucosa of 15 DU patients (3-2+/-0-8 mug/g) was higher (but not significantly) th... | 10.1136/gut.17.10.745 | 793,953 | D000328:Adult; D000368:Aged; D002452:Cell Count; D002986:Clinical Trials as Topic; D003594:Cytoplasmic Granules; D004381:Duodenal Ulcer; D004386:Duodenum; D005260:Female; D005753:Gastric Mucosa; D005755:Gastrins; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011706:Pyloric Antrum; D0... | Gut | 1,976 | D005755:Gastrins |
Assessment of a video system for scanning DNA autoradiographs. | A video based scanning system had been developed for processing DNA autoradiographs (T. Catterick and J.R. Russell, Lab. Microcomput. (1991), in press). Before the scanner was used in casework it was necessary to assess its performance. Test DNA samples containing fragments (alleles) of known kilobase size were run aga... | 10.1016/0379-0738(91)90167-h | 2,032,665 | D001345:Autoradiography; D004247:DNA; D006801:Humans; D015203:Reproducibility of Results; D014741:Video Recording | Forensic science international | 1,991 | D004247:DNA |
Motor Skill Learning-Induced Functional Plasticity in the Primary Somatosensory Cortex: A Comparison Between Young and Older Adults. | While in young adults (YAs) the underlying neural mechanisms of motor learning are well-studied, studies on the involvement of the somatosensory system during motor skill learning in older adults (OAs) remain sparse. Therefore, the aim of the present study was to investigate motor learning-induced neuroplasticity in th... | 10.3389/fnagi.2020.596438 | 33,324,196 | Frontiers in aging neuroscience | 2,020 | ||
Bronchiectasis and Marfan's syndrome. | Marfan's syndrome is a rare hereditary disorder characterized by skeletal, cardiovascular and ocular abnormalities. Pulmonary abnormalities occur in approximately 10% of patients the commonest being spontaneous pneumothorax and emphysema. A patient is described who had Marfan's syndrome and bronchiectasis, an associati... | 10.1136/pgmj.56.660.718 | 7,220,408 | D000328:Adult; D001987:Bronchiectasis; D006801:Humans; D008297:Male; D008382:Marfan Syndrome; D011859:Radiography | Postgraduate medical journal | 1,980 | |
The relationship between health eating and overweight/obesity in Canada: cross-sectional study using the CCHS. | Objective
The relationship between Canada's Food Guide (CFG) adherence and overweight/obesity at the population level is unknown. Our objective was to explore the association between overweight/obesity and CFG adherence in Canada.
Methods
Using 24-h dietary recall data from the Canadian Community Health Survey (CCHS)... | 10.1002/osp4.123 | 29,259,798 | Obesity science & practice | 2,017 | ||
N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase. | A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and a preliminary structure-activity relationship are described. A UV cross-linking experiment was used to map the allosteric binding site of the compoun... | 10.1021/jm901044z | 20,014,868 | D001665:Binding Sites; D003716:Dengue Virus; D004791:Enzyme Inhibitors; D006801:Humans; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D012324:RNA-Dependent RNA Polymerase; D013329:Structure-Activity Relationship; D013441:Sulfinic Acids; D062367:ortho-Aminobenzoates | Journal of medicinal chemistry | 2,009 | D004791:Enzyme Inhibitors; D013441:Sulfinic Acids; D062367:ortho-Aminobenzoates; D012324:RNA-Dependent RNA Polymerase |
Enhancement of friction between carbon nanotubes: an efficient strategy to strengthen fibers. | Interfacial friction plays a crucial role in the mechanical properties of carbon nanotube based fibers, composites, and devices. Here we use molecular dynamics simulation to investigate the pressure effect on the friction within carbon nanotube bundles. It reveals that the intertube frictional force can be increased by... | 10.1021/nn901515j | 20,020,757 | D017276:Friction; D037742:Nanotubes, Carbon; D014732:Vibration | ACS nano | 2,010 | D037742:Nanotubes, Carbon |
Hb H disease with various β hemoglobinopathies: molecular, hematological and diagnostic aspects. | We report the molecular, hematological and diagnostic features of three Thai patients with Hb H (β4) disease in combination with different β hemoglobinopathies. The first case was a boy with a hitherto undescribed condition of Hb H-Hb Tak (HBB:c.441_442insAC) syndrome. The second case was an adult male with the Hb H-Hb... | 10.3109/03630269.2011.638406 | 22,145,566 | D000328:Adult; D002648:Child; D004252:DNA Mutational Analysis; D004909:Erythrocyte Indices; D005838:Genotype; D006447:Hemoglobin H; D006453:Hemoglobinopathies; D006455:Hemoglobins, Abnormal; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D013785:Thailand; D017085:alpha-Thalassemia... | Hemoglobin | 2,012 | D006455:Hemoglobins, Abnormal; C111400:hemoglobin Tak; D006447:Hemoglobin H; C038623:hemoglobin Hope; C035541:Hemoglobin Constant Spring |
Effect of Listeria monocytogenes lipids on the course of infections with some gram-negative bacilli in mice. | The effect of Listeria monocytogenes lipids on the course of infections with Salmonella enteritidis, Yersinia pseudotuberculosis, Pseudomonas aeruginosa and Klebsiella pneumoniae was studied in mice. The lipids were extracted with chloroform and methanol and used in various doses before and after infection with the bac... | 109,064 | D000276:Adjuvants, Immunologic; D000818:Animals; D001424:Bacterial Infections; D004305:Dose-Response Relationship, Drug; D008055:Lipids; D008089:Listeria monocytogenes; D051379:Mice | Archivum immunologiae et therapiae experimentalis | 1,979 | D000276:Adjuvants, Immunologic; D008055:Lipids | |
Proliferative compartments in the normal nail unit. | The main distinction between the germinal matrix and the nail bed is that the former is the origin of all or most of the nail plate and the latter provides an epithelial surface to which the emerging nail can adhere. It has been argued that the nail bed may contribute substance to the nail plate and it is likely that i... | 8,915,145 | D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D019394:Ki-67 Antigen; D008875:Middle Aged; D008940:Mitotic Index; D009260:Nail Diseases; D009262:Nails; D018809:Proliferating Cell Nuclear Antigen | The British journal of dermatology | 1,996 | D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen | |
Suicidal behavior and parental psychopathology in hospitalized depressed children. | This study describes the suicidal behavior of hospitalized depressed children and assesses its relationship to psychopathology and suicidal behavior in their parents. Subjects were 58 consecutively hospitalized prepubertal children with a primary diagnosis of major depressive disorder (MDD), and 58 age- and gender-matc... | 10.1002/da.1064 | 11,747,128 | D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003865:Depressive Disorder, Major; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D010290:Parents; D013406:Suicide, Attempted | Depression and anxiety | 2,001 | |
Projections from the dorsal and ventral cochlear nuclei to the medial geniculate body. | Direct projections from the cochlear nucleus (CN) to the medial geniculate body (MG) mediate a high-speed transfer of acoustic information to the auditory thalamus. Anderson etal. (2006) used anterograde tracers to label the projection from the dorsal CN (DCN) to the MG in guinea pigs. We examined this pathway with ret... | 10.3389/fnana.2014.00010 | 24,634,646 | Frontiers in neuroanatomy | 2,014 | ||
Analysis of 344 Hand Injuries in a Pediatric Population. | BACKGROUND
The purpose of this study was to identify comprehensive hand injury patterns in different pediatric age groups and to assess their risk factors.
METHODS
This retrospective study was conducted among patients younger than 16-year-old who presented to the emergency room of a general hospital located in Gyeong... | 10.5999/aps.2016.43.1.71 | 26,848,449 | Archives of plastic surgery | 2,016 | ||
The transmembrane peptide DWORF activates SERCA2a via dual mechanisms. | The Ca-ATPase isoform 2a (SERCA2a) pumps cytosolic Ca2+ into the sarcoplasmic reticulum (SR) of cardiac myocytes, enabling muscle relaxation during diastole. Abnormally high cytosolic [Ca2+] is a central factor in heart failure, suggesting that augmentation of SERCA2a Ca2+ transport activity could be a promising therap... | 10.1016/j.jbc.2021.100412 | 33,581,112 | D002118:Calcium; D002135:Calcium-Binding Proteins; D002460:Cell Line; D057809:HEK293 Cells; D006333:Heart Failure; D006801:Humans; D009206:Myocardium; D032383:Myocytes, Cardiac; D010455:Peptides; D012519:Sarcoplasmic Reticulum; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases | The Journal of biological chemistry | 2,021 | D002135:Calcium-Binding Proteins; C000604949:DWORF peptide, human; D010455:Peptides; C016056:phospholamban; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; C506946:ATP2A2 protein, human; D002118:Calcium |
Computer-aided prediction and cytotoxicity evaluation of dithiocarbamates of 9,10-anthracenedione as new anticancer agents. | Anticancer activity as an associated action for a series of dithiocarbamates of 9,10-anthracenedione was predicted using the PASS computer program and analysed with PharmaExpert software. The predicted cytotoxic activity of the dithiocarbamate derivatives of 9,10-anthracenedione was evaluated in vitro on cancer cells o... | 10.1080/1062936X.2017.1323796 | 28,524,703 | D000072283:A549 Cells; D000880:Anthraquinones; D000970:Antineoplastic Agents; D002470:Cell Survival; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D061986:MCF-7 Cells; D021281:Quantitative Structure-Activity Relationship; D012235:Rhodamines; D012984:Software; D013859:Thiocarbamates; D014... | SAR and QSAR in environmental research | 2,017 | D000880:Anthraquinones; D000970:Antineoplastic Agents; D012235:Rhodamines; D013859:Thiocarbamates; C042834:9,10-anthraquinone; C022027:lissamine rhodamine B |
The influence of sensation-seeking and parental and peer influences in early adolescence on risk involvement through middle adolescence: A structural equation modeling analysis. | This study examined the relationships between youth and parental sensation-seeking, peer influence, parental monitoring and youth risk involvement in adolescence using structural equation modeling. Beginning in grade-six, longitudinal data were collected from 543 students over three years. Youth sensation-seeking in gr... | 10.1177/0044118X13487228 | 27,030,784 | Youth & society | 2,016 | ||
Induction of erythroid-specific genes by overexpression of GATA-2 in K562 cells. | GATA transcription factors have been shown to play important roles in hematopoiesis. GATA-2 is expressed in stem and progenitor cells, and has been speculated to control the proliferation and maintain the immaturity of these cells. To examine whether the function of GATA-2 is changeable according to the differentiation... | 10.1532/IJH97.06020 | 16,867,900 | D002454:Cell Differentiation; D002843:Chromatin; D015672:Erythroid Precursor Cells; D004920:Erythropoiesis; D050989:GATA2 Transcription Factor; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D020014:K562 Cells | International journal of hematology | 2,006 | D002843:Chromatin; D050989:GATA2 Transcription Factor |
Influence of constant lightning on liver health: an experimental study. | Light pollution has become a serious problem in many urbanized areas of the world. The impact of prolonged exposure to light and consequent disruption of natural circadian rhythms has significant health implications. The current study was undertaken to evaluate the effect of prolonged exposure to light, simulating urba... | 10.1007/s11356-022-21655-3 | 35,771,326 | D000818:Animals; D051381:Rats; D008030:Lightning; D002940:Circadian Rhythm; D008099:Liver | Environmental science and pollution research international | 2,022 | |
Outcomes in Medicare-ineligible people living with human immunodeficiency virus in a large healthcare network in Melbourne 2004-2019. | Australia has approximately 1.6 million Medicare-ineligible residents, of whom around 450 are living with human immunodeficiency virus (PLHIV). We examined the outcomes in a cohort of 50 Medicare-ineligible patients presenting to our hospital network over a 15-year period: 31 women (62%) and 19 men. Twenty-four were ne... | 10.1111/imj.15775 | 35,538,008 | D000368:Aged; D018791:CD4 Lymphocyte Count; D005260:Female; D006678:HIV; D015658:HIV Infections; D006297:Health Services Accessibility; D006801:Humans; D008297:Male; D009313:National Health Programs | Internal medicine journal | 2,022 | |
Comparison of the Incidence Rate of Radiation Pneumonitis Observed in Patients with Advanced Lung Adenocarcinoma Treated with Simultaneous Thoracic Radiotherapy and 1G/2G/3G EGFR-TKIs. | Purpose
The present study aimed to evaluate the incidence rate of radiation pneumonitis (RP) in patients with advanced lung adenocarcinoma treated with first-generation (1G), second-generation (2G), or third-generation (3G) epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) combined with thoracic r... | 10.2147/CMAR.S404874 | 37,077,536 | Cancer management and research | 2,023 | ||
Alternate Care Sites for COVID-19 Patients: Experience from the H144 Hospital of the Health Service of the Principality of Asturias, Spain. | Coronavirus disease 2019 (COVID-19) temporary hospitals, also called "alternate care sites" (ACS), as support to the health network have had uneven use. The World Health Organization (WHO) has published different recommendations in this regard. World-wide, many health services have improved their surge capacity with th... | 10.1017/S1049023X21001102 | 34,612,185 | D000369:Aged, 80 and over; D000086382:COVID-19; D005260:Female; D006760:Hospitalization; D006761:Hospitals; D006801:Humans; D008297:Male; D000086402:SARS-CoV-2; D013030:Spain | Prehospital and disaster medicine | 2,021 | |
[Effect of concomitant substances and addition order on the adsorption of Tween 80 on sand]. | Adsorption of Tween 80 on sand was investigated, and the effect of inorganic salts (CaCl2), anionic surfactant (SDS) and lignosulphonates (sodium lignosulphonate or ammonium lignosulphonate) on the adsorption of Tween 80 on sand were evaluated at 25 degrees C. The results show that saturated adsorption amount of Tween ... | 18,839,596 | D000327:Adsorption; D000838:Anions; D002122:Calcium Chloride; D008031:Lignin; D011136:Polysorbates; D012822:Silicon Dioxide; D012989:Soil Pollutants; D013501:Surface-Active Agents; D018505:Waste Management | Huan jing ke xue= Huanjing kexue | 2,008 | D000838:Anions; D011136:Polysorbates; D012989:Soil Pollutants; D013501:Surface-Active Agents; D012822:Silicon Dioxide; C001545:lignosulfuric acid; D008031:Lignin; D002122:Calcium Chloride | |
Reconsidering the prognostic significance of tumour deposit count in the TNM staging system for colorectal cancer. | Although the occurrence of tumour deposits (TDs) without metastatic lymph nodes (mLNs) is classified as "N1c" in the 8th TNM staging system for colorectal cancer (CRC), the prognostic significance of the TD count is still controversial. A total of 39155 CRC patients were collected from the Surveillance, Epidemiology, a... | 10.1038/s41598-019-57041-2 | 31,919,408 | D000230:Adenocarcinoma; D002288:Adenocarcinoma, Mucinous; D000368:Aged; D018279:Carcinoma, Signet Ring Cell; D015179:Colorectal Neoplasms; D000079822:Extranodal Extension; D005260:Female; D006801:Humans; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging; D015996:Survival Rate | Scientific reports | 2,020 | |
Serum MMP-9 and TIMP-1 levels are related to MRI activity in relapsing multiple sclerosis. | OBJECTIVE
To 1) compare monthly serum levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of MMP-type 1 (TIMP-1) in patients with relapsing-remitting MS (RRMS) versus healthy controls and 2) determine the relationship among monthly serum levels of MMP-9 and TIMP-1 and MRI activity.
BACKGROUND
Activated ... | 10.1212/wnl.53.7.1397 | 10,534,241 | D000293:Adolescent; D000328:Adult; D001921:Brain; D002648:Child; D005260:Female; D005682:Gadolinium; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020780:Matrix Metalloproteinase 9; D008875:Middle Aged; D009103:Multiple Sclerosis; D015999:Multivariate Analysis; D012008:Recurrence; D012016:Reference... | Neurology | 1,999 | D019715:Tissue Inhibitor of Metalloproteinase-1; D005682:Gadolinium; D020780:Matrix Metalloproteinase 9 |
Aromatase expression predicts survival in women with early-stage non small cell lung cancer. | Estrogen signaling is critical in the progression of tumors that bear estrogen receptors. In most patients with breast cancer, inhibitors that block interactions of estrogen with its receptors or suppress the production of endogenous estrogens are important interventions in the clinic. Recent evidence now suggests that... | 10.1158/0008-5472.CAN-07-2607 | 17,974,992 | D000328:Adult; D000368:Aged; D000818:Animals; D001141:Aromatase; D047072:Aromatase Inhibitors; D002289:Carcinoma, Non-Small-Cell Lung; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D012907:Smoking | Cancer research | 2,007 | D047072:Aromatase Inhibitors; D001141:Aromatase |
Incidence, surgical procedures, and outcomes of hip fracture among elderly type 2 diabetic and non-diabetic patients in Spain (2004-2013). | UNLABELLED
Hip fracture is a serious public health problem. We used Spanish hospital discharge data to examine trends in 2004-2013 in the incidence of hip fracture among elderly patients. We found that hip fracture incidence is higher in subjects with than without diabetes and is much higher among women than men.
INT... | 10.1007/s00198-015-3305-9 | 26,318,760 | D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip; D016208:Databases, Factual; D003924:Diabetes Mellitus, Type 2; D005260:Female; D005593:Fracture Fixation, Internal; D006620:Hip Fractures; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D008297:Male... | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA | 2,016 | |
iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks. | Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) that bind a specific regulatory element. We developed a microfluidic method for integrated systems-level interaction mapping of TF-D... | 10.1093/nar/gks1323 | 23,258,699 | D000818:Animals; D001483:Base Sequence; D016384:Consensus Sequence; D004247:DNA; D004331:Drosophila melanogaster; D015723:Gene Library; D053263:Gene Regulatory Networks; D046210:Microfluidic Analytical Techniques; D059372:Nucleotide Motifs; D056510:Position-Specific Scoring Matrices; D050436:Regulatory Elements, Transc... | Nucleic acids research | 2,013 | D014157:Transcription Factors; D004247:DNA |
Resonance Raman studies of Co-O2 and O-O stretching vibrations in oxy-cobalt hemes. | Strong evidence suggests that the stretching vibration of the bound oxygen can be perturbed by an accidentally degenerate porphyrin ring mode, resulting in two split frequencies. In the Co(II)(TpivPP) (pyridine) (18)O(2) complex, we demonstrate that the nu((18)O-(18)O) mode, after being shifted from its nu((16)O-(16)O)... | 10.1016/S0006-3495(83)84446-4 | 6,838,973 | D000818:Animals; D003035:Cobalt; D006418:Heme; D008968:Molecular Conformation; D009211:Myoglobin; D010100:Oxygen; D011166:Porphyrins; D013059:Spectrum Analysis, Raman; D014907:Whales | Biophysical journal | 1,983 | D009211:Myoglobin; D011166:Porphyrins; D003035:Cobalt; D006418:Heme; D010100:Oxygen |
Preoperative angiotensin-converting enzyme inhibitors protect myocardium from ischemia during coronary artery bypass graft surgery. | OBJECTIVES
Coronary artery bypass graft surgery may result in perioperative myocardial injury during cardioplegic arrest. Angiotensin-converting enzyme (ACE) inhibitors protect the myocardium from ischemia in several clinical conditions, but no previous study has attempted to evaluate the impact of preoperative ACE inh... | 10.2459/JCM.0b013e32830a6daf | 18,852,580 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors; D015415:Biomarkers; D001026:Coronary Artery Bypass; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia; D009206:Myocardium; D012189:... | Journal of cardiovascular medicine (Hagerstown, Md.) | 2,008 | D000806:Angiotensin-Converting Enzyme Inhibitors; D015415:Biomarkers; D019210:Troponin I |
Calcineurin/NFAT pathway mediates wear particle-induced TNF-α release and osteoclastogenesis from mice bone marrow macrophages in vitro. | AIM
To investigate the roles of the calcineurin/nuclear factor of activated T cells (NFAT) pathway in regulation of wear particles-induced cytokine release and osteoclastogenesis from mouse bone marrow macrophages in vitro.
METHODS
Osteoclasts were induced from mouse bone marrow macrophages (BMMs) in the presence of ... | 10.1038/aps.2013.99 | 24,056,707 | D000818:Animals; D001854:Bone Marrow Cells; D019703:Calcineurin; D002454:Cell Differentiation; D002470:Cell Survival; D004797:Enzyme-Linked Immunosorbent Assay; D008264:Macrophages; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D050778:NFATC Transcription Factors; D009842:Oligopeptides; D010010:Osteoclasts; D... | Acta pharmacologica Sinica | 2,013 | D050778:NFATC Transcription Factors; D009842:Oligopeptides; D053245:RANK Ligand; D014409:Tumor Necrosis Factor-alpha; C121611:VIVIT peptide; D019904:Polymethyl Methacrylate; D014025:Titanium; D019703:Calcineurin |
In vitro effects of three metallic salts and soot on the growth of five species of the dermatophytes. | The antifungal effects of zinc chloride (znCl), Calcium chloride (CaCl), magnesium chloride (MgCl) as well as soot collected from a local kitchens were tested on five isolated species of the dermatophytes from cases of human dermatophytoses. Of these three metallic salts, ZnCl showed the highest inhibitory effect on th... | 10,916,611 | D003883:Arthrodermataceae; D002122:Calcium Chloride; D002244:Carbon; D002712:Chlorides; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015636:Magnesium Chloride; D017967:Zinc Compounds | The Journal of communicable diseases | 1,999 | D002712:Chlorides; D017967:Zinc Compounds; D015636:Magnesium Chloride; D002244:Carbon; C016837:zinc chloride; D002122:Calcium Chloride | |
Adaptive radiation and hybridization in Wallace's Dreamponds: evidence from sailfin silversides in the Malili Lakes of Sulawesi. | Adaptive radiations are extremely useful to understand factors driving speciation. A challenge in speciation research is to distinguish forces creating novelties and those relevant to divergence and adaptation. Recently, hybridization has regained major interest as a potential force leading to functional novelty and to... | 10.1098/rspb.2006.3558 | 16,901,841 | D000220:Adaptation, Biological; D000818:Animals; D001483:Base Sequence; D001499:Bayes Theorem; D004272:DNA, Mitochondrial; D005618:Fresh Water; D049810:Genetic Speciation; D006824:Hybridization, Genetic; D007214:Indonesia; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010802:Phylogeny; D025341:Principal Co... | Proceedings. Biological sciences | 2,006 | D004272:DNA, Mitochondrial |
Integrative medicine as adjunct therapy in the treatment of atopic dermatitis--the role of traditional Chinese medicine, dietary supplements, and other modalities. | Atopic dermatitis (AD) is becoming increasingly prevalent in the pediatric population, with rates reportedly as high as 18-25 %. Westernized medicine has traditionally used a combination of emollients, antihistamines, corticosteroids, and immunomodulating agents to combat this often frustrating disease. Of late, integr... | 10.1007/s12016-012-8315-1 | 22,661,238 | D000818:Animals; D003876:Dermatitis, Atopic; D019587:Dietary Supplements; D006801:Humans; D055048:Integrative Medicine; D008516:Medicine, Chinese Traditional; D019936:Probiotics; D058616:Synbiotics | Clinical reviews in allergy & immunology | 2,013 | |
The psychiatric training of medical students. | Undergraduate psychiatric education should be concerned mostly with those aspects of psychiatry required for the proper practice of medicine. Psychiatric concepts and techniques are applicable to all medical practice and relevant to the daily work of every physician or surgeon. Therefore, in the psychiatric training of... | 10.1177/070674378102600504 | 7,296,445 | D002170:Canada; D003376:Counseling; D003479:Curriculum; D004504:Education, Medical, Undergraduate; D006801:Humans; D011570:Psychiatry; D011613:Psychotherapy; D013038:Specialization; D013044:Specialty Boards | Canadian journal of psychiatry. Revue canadienne de psychiatrie | 1,981 | |
Imiquimod is highly effective for extensive, hyperproliferative condyloma in children. | We describe a dramatic response to imiquimod of long-lasting, highly proliferative extensive perianal condylomas involving the anal canal in a 19-month-old girl. Her mother was free of condyloma and allegedly had no human papillomavirus (HPV) infection during pregnancy. There was no evidence of sexual abuse. Applicatio... | 10.1046/j.1525-1470.2003.20516.x | 14,521,566 | D000287:Administration, Topical; D000634:Aminoquinolines; D003218:Condylomata Acuminata; D005260:Female; D006801:Humans; D000077271:Imiquimod; D007223:Infant | Pediatric dermatology | 2,003 | D000634:Aminoquinolines; D000077271:Imiquimod |
Role of catalase in monocytic differentiation of U937 cells by TPA: hydrogen peroxide as a second messenger. | Human promonocytic cell line U937 cells can be induced to differentiate into macrophages by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA). TPA treatment induced the expression of the monocytic differentiation markers CD11b and CD36, with concomitant morphological changes. Moreover, TPA enhanced reactive oxy... | 10.1038/leu.2008.353 | 19,092,850 | D002374:Catalase; D002454:Cell Differentiation; D006801:Humans; D006861:Hydrogen Peroxide; D008264:Macrophages; D009000:Monocytes; D017382:Reactive Oxygen Species; D015290:Second Messenger Systems; D013482:Superoxide Dismutase; D013755:Tetradecanoylphorbol Acetate; D020298:U937 Cells | Leukemia | 2,009 | D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase; D013755:Tetradecanoylphorbol Acetate |
Physician nutrition education. | Nutrition education for physicians in the United States is limited in scope, quality, and duration due to a variety of factors. As new data and quality improvement initiatives highlight the importance of nutrition and a generation of nutrition experts retire, there is a need for new physician educators and leaders in c... | 10.1177/0884533614525212 | 24,690,613 | D002568:Certification; D004501:Education, Medical; D005257:Fellowships and Scholarships; D006801:Humans; D052756:Nutritional Sciences; D010820:Physicians; D014481:United States | Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition | 2,014 | |
Design of allele-specific protein methyltransferase inhibitors. | Protein arginine methyltransferases, which catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to arginine side chains in target proteins, regulate transcription, RNA processing, and receptor-mediated signaling. To specifically address the functional role of the individual members of this family, we ... | 10.1021/ja011423j | 11,716,715 | D000483:Alleles; D000595:Amino Acid Sequence; D001665:Binding Sites; D015195:Drug Design; D004791:Enzyme Inhibitors; D007700:Kinetics; D016297:Mutagenesis, Site-Directed; D011487:Protein Conformation; D011484:Protein-Arginine N-Methyltransferases; D012436:S-Adenosylmethionine; D012441:Saccharomyces cerevisiae; D017386:... | Journal of the American Chemical Society | 2,001 | D004791:Enzyme Inhibitors; D012436:S-Adenosylmethionine; D011484:Protein-Arginine N-Methyltransferases |
Essential structural profile of a dual functional inhibitor against cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): molecular docking and 3D-QSAR analyses on DHDMBF analogues. | It is recently proposed that compounds with equal capabilities of inhibiting COX and 5-LOX, both are key enzymes involved in the arachidonic acid (AA) cascade, are expected to be safer non-steroidal anti-inflammatory drugs (NSAIDs). To dig out helpful information in designing dual functional inhibitors against the two ... | 10.1016/j.bmc.2005.12.062 | 16,458,008 | D000595:Amino Acid Sequence; D000818:Animals; D001094:Arachidonate 5-Lipoxygenase; D001572:Benzofurans; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D006801:Humans; D016859:Lipoxygenase Inhibitors; D008565:Membrane Proteins; D008958:Models, Molecular; D015394:Molecular Structure; D017433:Protein Struc... | Bioorganic & medicinal chemistry | 2,006 | D001572:Benzofurans; D052246:Cyclooxygenase 2 Inhibitors; D016859:Lipoxygenase Inhibitors; D008565:Membrane Proteins; D001094:Arachidonate 5-Lipoxygenase; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human |
Optimality of profit-including prices under ideal planning. | Although prices calculated by a constant percentage markup on all costs (nonlabor as well as direct-labor) are usually admitted to be more realistic for a competitive capitalistic model, the view is often expressed that, for optimal planning purposes, the "values" model of Marx's Capital, Volume I, is to be preferred. ... | 10.1073/pnas.70.7.2109 | 16,592,102 | Proceedings of the National Academy of Sciences of the United States of America | 1,973 | ||
Cell-specific exon methylation and CTCF binding in neurons regulate calcium ion channel splicing and function. | Cell-specific alternative splicing modulates myriad cell functions and is disrupted in disease. The mechanisms governing alternative splicing are known for relatively few genes and typically focus on RNA splicing factors. In sensory neurons, cell-specific alternative splicing of the presynaptic CaV channel Cacna1b gene... | 32,213,287 | D017398:Alternative Splicing; D000818:Animals; D000076246:CCCTC-Binding Factor; D020864:Calcium Channels, N-Type; D019070:Cell Lineage; D002478:Cells, Cultured; D004248:DNA (Cytosine-5-)-Methyltransferases; D019175:DNA Methylation; D000090205:DNA Methyltransferase 3A; D005091:Exons; D005727:Ganglia, Spinal; D051379:Mic... | eLife | 2,020 | D000076246:CCCTC-Binding Factor; C500963:Cacna1b protein, mouse; D020864:Calcium Channels, N-Type; C000619698:Ctcf protein, mouse; D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A | |
Factor VIII-driven changes in activated factor IX explored by hydrogen-deuterium exchange mass spectrometry. | The assembly of the enzyme-activated factor IX (FIXa) with its cofactor, activated factor VIII (FVIIIa) is a crucial event in the coagulation cascade. The absence or dysfunction of either enzyme or cofactor severely compromises hemostasis and causes hemophilia. FIXa is a notoriously inefficient enzyme that needs FVIIIa... | 10.1182/blood.2020005593 | 32,678,887 | D000494:Allosteric Regulation; D041961:Deuterium Exchange Measurement; D015949:Factor IXa; D005169:Factor VIII; D002836:Hemophilia B; D006801:Humans; D013058:Mass Spectrometry; D009154:Mutation; D000072756:Protein Conformation, alpha-Helical; D000072417:Protein Domains | Blood | 2,020 | C078147:F8 protein, human; D005169:Factor VIII; D015949:Factor IXa |
Towards identifying enablers and inhibitors to on-farm entrepreneurship: evidence from smallholders in KwaZulu-Natal, South Africa. | Enabling on-farm entrepreneurship is an important step to enhance the contribution of smallholder agriculture to rural employment and poverty reduction in South Africa. Using attributes derived from positive psychological capital as proxies for entrepreneurship and data collected from 458 smallholders in and around irr... | 10.1016/j.heliyon.2020.e05660 | 33,553,709 | Heliyon | 2,021 | ||
Visual Acuity: Assessment of Data Quality and Usability in an Electronic Health Record System. | Objective
To examine the data quality and usability of visual acuity (VA) data extracted from an electronic health record (EHR) system during ophthalmology encounters and provide recommendations for consideration of relevant VA end points in retrospective analyses.
Design
Retrospective, EHR data analysis.
Participa... | 10.1016/j.xops.2022.100215 | 36,275,199 | Ophthalmology science | 2,023 | ||
Hypoxia-induced alterations in cytoskeleton coincide with collagenase expression in cultured neonatal rat cardiomyocytes. | Incubation of cultured neonatal rat cardiomyocytes in hypoxic conditions, mimicking the deprivation of O2 which occurs during in situ myocardial ischemia, leads to a progressive change in cardiomyocytes cytoskeletal components. Confocal scanning laser immunofluorescence microscopy (CSLIM) reveals that the typical stria... | 10.1006/jmcc.1995.0040 | 8,825,874 | D000255:Adenosine Triphosphate; D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D017364:Collagenases; D003599:Cytoskeleton; D000860:Hypoxia; D009206:Myocardium; D010101:Oxygen Consumption; D051381:Rats; D012508:Sarcolemma | Journal of molecular and cellular cardiology | 1,995 | D000255:Adenosine Triphosphate; D017364:Collagenases |
Viral causes of sensorineural hearing loss. | Many viruses, even the common cold, are capable of producing sensorineural hearing loss. Treatment so far available is ineffective in correcting these losses. However, as the technology of vaccination advances, it is hoped that these can be prevented. Poliomyelitis and smallpox have been virtually eliminated from this ... | 662,351 | D003051:Cochlea; D003638:Deafness; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012409:Rubella; D014777:Virus Diseases | Otolaryngologic clinics of North America | 1,978 | ||
Effect of controlled hyperventilation on the pressor response to laryngoscopy and tracheal intubation. | Pressor response to laryngoscopy and tracheal intubation includes rises in blood pressure and heart rate. This response may be harmful in the presence of cerebral or myocardial diseases. Although different preventive measures have been developed the choice of the agent or method has not been defined clearly. Hypocapnia... | 14,740,593 | D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure; D002245:Carbon Dioxide; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension; D006985:Hyperventilation; D016857:Hypocapnia; D007022:Hypotension; D007442:Intubation, Intratracheal; D007828:Laryngoscopy; D008297:Male; D011446:Prospec... | Middle East journal of anaesthesiology | 2,003 | D002245:Carbon Dioxide | |
Evaluation. Closing the loop. | After implementing a new nursing care delivery system, evaluating its outcomes is essential. An evaluation process answers key questions: (1) Were planned outcomes achieved? (2) Were the users satisfied? (3) Does the delivery system need to be modified? | 9,807,411 | D000208:Acute Disease; D003266:Continuity of Patient Care; D006801:Humans; D007588:Job Satisfaction; D009732:Nursing Care; D009741:Nursing Staff, Hospital; D017063:Outcome Assessment, Health Care; D015397:Program Evaluation | Nursing management | 1,998 | ||
Structure-activity relationships of 2',5'-oligoadenylate analogue modifications of prostate-specific membrane antigen (PSMA) antagonists. | Prostate-specific membrane antigen (PSMA) is an ideal biomarker for prostate cancer. A previously reported 2-5A conjugate RBI1033 (3) showed binding affinity more than 10 times higher than the parent urea-based compound (S)-2-(3-((S)-5-amino-1-carboxypentyl)ureido) pentanedioic acid (1). The purpose of this work is to ... | 10.1080/15257770.2012.671988 | 22,497,258 | D000227:Adenine Nucleotides; D000954:Antigens, Surface; D001667:Binding, Competitive; D001692:Biological Transport; D045744:Cell Line, Tumor; D043425:Glutamate Carboxypeptidase II; D006801:Humans; D008024:Ligands; D008297:Male; D057054:Molecular Imaging; D009362:Neoplasm Metastasis; D009843:Oligoribonucleotides; D01147... | Nucleosides, nucleotides & nucleic acids | 2,012 | D000227:Adenine Nucleotides; D000954:Antigens, Surface; D008024:Ligands; D009843:Oligoribonucleotides; D011480:Protease Inhibitors; C023505:2',5'-oligoadenylate; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II |
Strengthening the Canadian alcohol advertising regulatory system. | Research evidence points to harmful effects from alcohol advertising among children and youth. In particular, exposure to alcohol advertising has been associated with adolescents drinking both earlier and heavier. Although current federal and provincial guidelines have addressed advertising practices to prevent underag... | 23,618,638 | D000293:Adolescent; D000329:Advertising; D000428:Alcohol Drinking; D002170:Canada; D002648:Child; D033161:Government Regulation; D006291:Health Policy; D006801:Humans | Canadian journal of public health = Revue canadienne de sante publique | 2,012 | ||
Effect of dietary fat on Ito cell activation by chronic ethanol intake: a long-term serial morphometric study on alcohol-fed and control rats. | We studied the effects of long-term ethanol ingestion and dietary fat on Ito cell activation morphometrically in rats. Sixteen pairs of Wistar male rats were divided into two groups, one fed tallow and the other fed corn oil as the source of dietary fat. Each group of rats were pair-fed a nutritional adequate liquid di... | 10.1111/j.1530-0277.1991.tb05212.x | 1,789,382 | D000818:Animals; D001706:Biopsy; D004041:Dietary Fats; D004721:Endoplasmic Reticulum; D050356:Lipid Metabolism; D008099:Liver; D008104:Liver Cirrhosis, Alcoholic; D008112:Liver Glycogen; D008115:Liver Regeneration; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains | Alcoholism, clinical and experimental research | 1,991 | D004041:Dietary Fats; D008112:Liver Glycogen |
Effects of Platelet-Rich Fibrin on Palatal Wound Healing After Free Gingival Graft Harvesting: A Comparative Randomized Controlled Clinical Trial. | This study was conducted to evaluate the effects of platelet-rich fibrin (PRF) on palatal wound healing after free gingival graft (FGG) harvesting. A total of 125 patients were randomized after FGG: PRF with butyl-cyanoacrylate (BC) adhesive (PRF group; n = 42), BC adhesive alone (BC group; n = 42), and sterile wet gau... | 10.11607/prd.3226 | 28,817,141 | D000328:Adult; D003738:Dental Cements; D004659:Enbucrilate; D005260:Female; D005881:Gingiva; D006801:Humans; D008297:Male; D008875:Middle Aged; D010159:Palate; D000073183:Platelet-Rich Fibrin; D011137:Polystyrenes; D019106:Postoperative Hemorrhage; D014945:Wound Healing; D055815:Young Adult | The International journal of periodontics & restorative dentistry | 2,017 | D003738:Dental Cements; D011137:Polystyrenes; C473120:butylcyanoacrylate-graft-polystyrene; D004659:Enbucrilate |
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