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Identification of a new strain of mouse kidney parvovirus associated with inclusion body nephropathy in immunocompromised laboratory mice. | Inclusion body nephropathy (IBN) and kidney fibrosis in aged immunodeficient mice and, to lesser extent, in immunocompetent mice have been recently linked to infection of mouse kidney parvovirus (MKPV), also known as murine chapparvovirus (MuCPV). Knowledge about its prevalence and the complete genome sequence of more ... | 10.1080/22221751.2020.1798288 | 32,686,622 | D000595:Amino Acid Sequence; D000818:Animals; D005355:Fibrosis; D016679:Genome, Viral; D016867:Immunocompromised Host; D007181:Inclusion Bodies, Viral; D007668:Kidney; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D016688:Mice, Inbred NOD; D018345:Mice, Knockout; D009422:Nervous System Diseases; D... | Emerging microbes & infections | 2,020 | |
Some negatively charged phospholipid derivatives prolong the liposome circulation in vivo. | A series of negatively charged phospholipid derivatives has been synthesized by coupling aliphatic dicarboxylic acids, HOOC(CH2)nCOOH, to dioleoylphosphatidylethanolamine (DOPE). The individual derivatives were incorporated into egg phosphatidylcholine/cholesterol liposomes (2:1, molar ratio) and injected into mice to ... | 10.1016/0005-2736(92)90034-j | 1,637,850 | D000818:Animals; D008081:Liposomes; D051379:Mice; D008958:Models, Molecular; D010714:Phosphatidylethanolamines; D010743:Phospholipids | Biochimica et biophysica acta | 1,992 | D008081:Liposomes; D010714:Phosphatidylethanolamines; D010743:Phospholipids; C020888:1,2-dielaidoylphosphatidylethanolamine |
Clinicoradiological features associated with epidermal growth factor receptor exon 19 and 21 mutation in lung adenocarcinoma. | AIM
To retrospectively identify clinicopathological and radiological characteristics that could be independent predictors of epidermal growth factor receptor (EGFR) exon 19 and 21 mutation in surgically resected lung adenocarcinomas in a cohort of Asian patients.
MATERIALS AND METHODS
Demographics, histopathology dat... | 10.1016/j.crad.2018.10.001 | 30,591,175 | D000230:Adenocarcinoma; D066246:ErbB Receptors; D005091:Exons; D005260:Female; D006801:Humans; D008168:Lung; D008175:Lung Neoplasms; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012189:Retrospective Studies | Clinical radiology | 2,019 | D066246:ErbB Receptors |
[Family function and depression in relatives of earthquake victims: a survey conducted one year after China's Wenchuan Earthquake]. | BACKGROUND
The Wenchuan Earthquake that hit Sichuan, China in 2008 not only caused huge losses in terms of human life and economic damage. It also caused psychological trauma in survivors, especially those who had lost relatives and close friends (bereaved). In the aftermath of earthquakes, bereaved individuals require... | 23,034,548 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D003430:Cross-Sectional Studies; D003863:Depression; D055866:Earthquakes; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D008603:Mental Health; D008875:Middle Aged | Hu li za zhi The journal of nursing | 2,012 | ||
Monoclonal antibody specific to virulence-associated 15- to 17-kilodalton antigens of Rhodococcus equi. | Virulent Rhodococcus equi produces 15- to 17-kDa surface protein antigens. These antigens are used as markers to identify virulent R. equi isolates from foals and their environment by Western blot (immunoblot) analysis with naturally infected foal serum. In the present study, a monoclonal antibody (MAb; 10G5) was gener... | 10.1128/jcm.31.10.2780-2782.1993 | 8,253,982 | D000818:Animals; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D016929:Rhodococcus equi; D014774:Virulence | Journal of clinical microbiology | 1,993 | D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D000954:Antigens, Surface |
[Effect of resveratrol on lipopolysaccharide-induced activation of rat peritoneal macrophages]. | OBJECTIVE
To investigate nuclear factor kappa B (NF-kappaB) activation induced by lipopolysaccharide (LPS) in rat peritoneal macrophages (PMAs) and the inhibitory effect of resveratrol on NF-kappaB activation.
METHODS
PMAS from normal SD rats were randomly divided into 7 groups, including a control group, a LPS group... | 16,982,457 | D000818:Animals; D016207:Cytokines; D008070:Lipopolysaccharides; D008262:Macrophage Activation; D017737:Macrophages, Peritoneal; D008297:Male; D016328:NF-kappa B; D009569:Nitric Oxide; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D013267:Stilbenes | Nan fang yi ke da xue xue bao = Journal of Southern Medical University | 2,006 | D016207:Cytokines; D008070:Lipopolysaccharides; D016328:NF-kappa B; D013267:Stilbenes; D009569:Nitric Oxide; D000077185:Resveratrol | |
Case of sudden death following rupture of thoracic aortic aneurysm during "a manual therapy" procedure in the spinal area. | The reported case concerns the rupture of an aneurysm located in the descending part of the thoracic aorta during the procedure of the so-called "spinal adjustment" performed by a chiropractor. A 45-year-old patient with no significant medical history of cardiovascular diseases visited, along with his wife, one of "man... | 10.5114/amsik.2014.50529 | 25,909,919 | D017542:Aneurysm, Ruptured; D017545:Aortic Aneurysm, Thoracic; D001344:Autopsy; D001416:Back Pain; D016757:Death, Sudden, Cardiac; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008349:Manipulation, Orthopedic; D008875:Middle Aged | Archiwum medycyny sadowej i kryminologii | 2,014 | |
Design of Photosensitizing Agents for Targeted Antimicrobial Photodynamic Therapy. | Photodynamic inactivation of microorganisms has gained substantial attention due to its unique mode of action, in which pathogens are unable to generate resistance, and due to the fact that it can be applied in a minimally invasive manner. In photodynamic therapy (PDT), a non-toxic photosensitizer (PS) is activated by ... | 10.3390/molecules25225239 | 33,182,751 | D000818:Animals; D000890:Anti-Infective Agents; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008081:Liposomes; D051379:Mice; D008823:Micelles; D009844:Oligosaccharides; D010455:Peptides; D010778:Photochemotherapy; D017319:Photosensitizing Agents; D011108:Polymers; D026082:Singlet Oxygen; D055672:Static Electric... | Molecules (Basel, Switzerland) | 2,020 | D000890:Anti-Infective Agents; D008081:Liposomes; D008823:Micelles; D009844:Oligosaccharides; D010455:Peptides; D017319:Photosensitizing Agents; D011108:Polymers; D013481:Superoxides; D026082:Singlet Oxygen |
With or without you: crosstalk between cell division and flagellum assembly. | In this issue of Developmental Cell, Siwach et al. describe a novel mechanism found in α-proteobacteria that links flagellar biosynthesis and cell division via a regulator that senses proper flagellar assembly. This spatial and temporal checkpoint control helps ensure inheritance of a flagellum during cell division. | 10.1016/j.devcel.2021.02.013 | 33,689,768 | D001426:Bacterial Proteins; D002455:Cell Division; D005407:Flagella | Developmental cell | 2,021 | D001426:Bacterial Proteins |
Investigation on the Essential Oils of the Achillea Species: From Chemical Analysis to the In Silico Uptake against SARS-CoV-2 Main Protease. | In this study, phytochemicals extracted from three different Achillea genera were identified and analyzed to be screened for their interactions with the SARS-CoV-2 main protease. In particular, the antiviral potential of these natural products against the SARS-CoV-2 main protease was investigated, as was their effectiv... | 10.3390/life13020378 | 36,836,736 | Life (Basel, Switzerland) | 2,023 | ||
Urban/rural differences in health service utilization by elderly persons in the United States. | This paper presents the results of a longitudinal analysis of differences between urban and rural elderly persons in the use of hospital, nursing home, and physician services. Multivariate logistic and Tobit utilization models were estimated with data from the National Center for Health Statistics' Longitudinal Study o... | 10.1111/j.1748-0361.1993.tb00523.x | 10,131,304 | D000368:Aged; D000704:Analysis of Variance; D005843:Geography; D006299:Health Services for the Aged; D006761:Hospitals; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D009735:Nursing Homes; D010820:Physicians; D012044:Regression Analysis; D012423:Rural Health; D014504:Urban Health | The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association | 1,993 | |
[Distortion product otoacoustic emissions in newborns treated by ototoxic drugs]. | OBJECTIVE
The aim of this prospective longitudinal study is to research the amplitude of distortion product otoacoustic emissions caused by the ototoxic drugs used, between the end of the administration and from 15 to 40 days after its use.
METHODS
It was a prospective longitudinal study composed by term and preterm ... | 17,633,664 | D000583:Amikacin; D000617:Aminoglycosides; D015834:Cochlear Diseases; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural; D006801:Humans; D007231:Infant, Newborn; D010033:Otitis Media; D017084:Otoacoustic Emissions, Spontaneous; D011446:Prospective Studies; D012720:Severity of Illness Index; D014640:Vancomy... | Revue de laryngologie - otologie - rhinologie | 2,007 | D000617:Aminoglycosides; D014640:Vancomycin; D000583:Amikacin | |
Otezla, Warts and All, Racks Up Sales and Eyes Blockbuster Status. | Otezla-the generic name is apremilast-also exploited a new mechanism of action as the first inhibitor of phosphodiesterase 4 (PDE4) that results in increased expression of both anti-inflammatory proteins and reduced expression of their pro-inflammatory counterparts. | 29,068,290 | D000284:Administration, Oral; D006801:Humans; D058988:Phosphodiesterase 4 Inhibitors; D011565:Psoriasis; D013792:Thalidomide; D014481:United States | Managed care (Langhorne, Pa.) | 2,017 | D058988:Phosphodiesterase 4 Inhibitors; D013792:Thalidomide; C505730:apremilast | |
Trimodal Waveguide Demonstration and Its Implementation as a High Order Mode Interferometer for Sensing Application. | This work implements and demonstrates an interferometric transducer based on a trimodal optical waveguide concept. The readout signal is generated from the interference between the fundamental and second-order modes propagating on a straight polymer waveguide. Intuitively, the higher the mode order, the larger the frac... | 10.3390/s19122821 | 31,238,583 | Sensors (Basel, Switzerland) | 2,019 | ||
Cochlear Immune Response in Presbyacusis: a Focus on Dysregulation of Macrophage Activity. | Age-related hearing loss, or presbyacusis, is a prominent chronic degenerative disorder that affects many older people. Based on presbyacusis pathology, the degeneration occurs in both sensory and non-sensory cells, along with changes in the cochlear microenvironment. The progression of age-related neurodegenerative di... | 10.1007/s10162-021-00819-x | 34,642,854 | D000368:Aged; D000818:Animals; D003051:Cochlea; D006319:Hearing Loss, Sensorineural; D006801:Humans; D007109:Immunity; D008264:Macrophages; D051379:Mice; D011304:Presbycusis | Journal of the Association for Research in Otolaryngology : JARO | 2,022 | |
Unitarity of Symplectic Fermions in α Vacua with Negative Central Charge. | We study the two-dimensional free symplectic fermion theory with antiperiodic boundary condition. This model has negative norm states with a naive inner product. This negative norm problem can be cured by introducing a new inner product. We demonstrate that this new inner product follows from the connection between the... | 10.1103/PhysRevLett.130.241602 | 37,390,422 | Physical review letters | 2,023 | ||
Maintenance Enforcement Act, 11 May 1988. | This Act establishes a Director of Maintenance Enforcement in Prince Edward Island, Canada, to enforce maintenance "in such manner, if any, as appears practicable." Under the Act, extraprovincial garnishments are recognized, and maintenance orders may be registered against land with authority to force the sale of that... | 12,289,664 | D000569:Americas; D001519:Behavior; D002170:Canada; D002654:Child Care; D002668:Child Rearing; D019049:Developed Countries; D004467:Economics; D005376:Financial Management; D007878:Legislation as Topic; D009656:North America | Annual review of population law | 1,988 | ||
Serum Pro-oxidant-antioxidant Balance in Subjects with Type 2 Diabetes Mellitus. | AIM AND OBJECTIVE
Diabetes mellitus is associated with inflammation and increased oxidative stress. In the current study, we aimed to investigate the relationship between type 2 diabetes mellitus (T2DM) and serum pro-oxidant-antioxidant balance (PAB) in a large populationbased study.
METHODS
In this cross-sectional s... | 10.2174/1386207323999201103203153 | 33,155,893 | D000328:Adult; D000368:Aged; D000975:Antioxidants; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2; D006801:Humans; D008875:Middle Aged; D017382:Reactive Oxygen Species | Combinatorial chemistry & high throughput screening | 2,021 | D000975:Antioxidants; D017382:Reactive Oxygen Species |
Results of videokinesiography in patients with a complicated course of acute cerebrovascular disorder by hemitype in the recovery period. | Restoration of the masticatory function is one of the key elements in the comprehensive rehabilitation for patients with acute cerebrovascular disorders (ACVD) of various degrees, as their consequences may include an impaired coordinated action of the neuromuscular system, and the dentoalveolar system in particular. In... | 35,801,602 | D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible; D008409:Mastication; D020521:Stroke | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego | 2,022 | ||
Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation. | Introduction: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with increased mortality and morbidity. The Exchange Protein directly Activated by cAMP (EPAC), has been implicated in pro-arrhythmic signaling pathways in the atria, but the underlying mechanisms remain unknown. Me... | 10.3389/fphys.2023.1120336 | 36,909,224 | Frontiers in physiology | 2,023 | ||
Liver and cardiovascular mortality after hepatitis C virus eradication by DAA: Data from RESIST-HCV cohort. | Real-world evidence on the course of Hepatitis C Virus (HCV) chronic liver disease after Sustained Virologic Response (SVR) obtained with direct-acting antiviral drugs (DAAs) are still limited, and the effects on mortality remain unclear. We evaluated the post-treatment survival of 4307 patients in the RESIST-HCV cohor... | 10.1111/jvh.13523 | 33,896,097 | D000368:Aged; D000998:Antiviral Agents; D002318:Cardiovascular Diseases; D005260:Female; D016174:Hepacivirus; D006526:Hepatitis C; D019698:Hepatitis C, Chronic; D006801:Humans; D008297:Male; D008875:Middle Aged | Journal of viral hepatitis | 2,021 | D000998:Antiviral Agents |
Beyond Tanner's law: crossover between spreading regimes of a viscous droplet on an identical film. | We present results on the leveling of polymer microdroplets on thin films prepared from the same material. In particular, we explore the crossover from a droplet spreading on an infinitesimally thin film (Tanner's law regime) to that of a droplet leveling on a film thicker than the droplet itself. In both regimes, the ... | 10.1103/PhysRevLett.109.154501 | 23,102,314 | Physical review letters | 2,012 | ||
Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity. | Polycomb group proteins are transcriptional repressors that play a central role in the establishment and maintenance of gene expression patterns during development. Using mice with an N-ethyl-N-nitrosourea (ENU)-induced mutation in Suppressor of Zeste 12 (Suz12), a core component of Polycomb Repressive Complex 2 (PRC2)... | 10.1371/journal.pbio.0060093 | 18,416,604 | D000483:Alleles; D000818:Animals; D005260:Female; D006412:Hematopoietic Stem Cells; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation; D010641:Phenotype; D063151:Polycomb Repressive Complex 2; D063146:Polycomb-Group Proteins; D012333:RNA, Messenger; D012097:Repressor Proteins | PLoS biology | 2,008 | D063146:Polycomb-Group Proteins; D012333:RNA, Messenger; D012097:Repressor Proteins; C494163:Suz12 protein, mouse; D063151:Polycomb Repressive Complex 2 |
[Evaluation of preoperative anxiety in patients requiring glaucoma filtration surgery]. | PURPOSE
Preoperative anxiety is often expressed by patients requiring filtration surgery for their glaucoma. So far, there has been no scale for screening this group of patients for preoperative anxiety. The Amsterdam Preoperative Anxiety and Information Scale (APAIS) is a self-evaluation questionnaire which has been u... | 24,262,110 | D000328:Adult; D000368:Aged; D000758:Anesthesia; D001007:Anxiety; D005260:Female; D018463:Filtering Surgery; D005901:Glaucoma; D006801:Humans; D008297:Male; D008875:Middle Aged; D010353:Patient Education as Topic; D057234:Preoperative Period; D014130:Trabeculectomy | Journal francais d'ophtalmologie | 2,014 | ||
The effect of menthol on acute experimental colitis in rats. | Menthol is an aromatic compound with high antiinflammatory activity. The purpose of the current research is to investigate the effectiveness of menthol on acetic acid induced acute colitis in rats. Animals were injected with menthol (20 and 50 and 80mg/kg, i.p.) 24h prior to induction of colitis for 3 consecutive days.... | 10.1016/j.ejphar.2017.03.003 | 28,322,843 | D000208:Acute Disease; D000818:Animals; D001835:Body Weight; D003092:Colitis; D003106:Colon; D016207:Cytokines; D004195:Disease Models, Animal; D006400:Hematocrit; D008297:Male; D008610:Menthol; D009195:Peroxidase; D051381:Rats; D017208:Rats, Wistar | European journal of pharmacology | 2,017 | D016207:Cytokines; D008610:Menthol; D009195:Peroxidase |
Predicting disruptive instabilities in controlled fusion plasmas through deep learning. | Nuclear fusion power delivered by magnetic-confinement tokamak reactors holds the promise of sustainable and clean energy1. The avoidance of large-scale plasma instabilities called disruptions within these reactors2,3 is one of the most pressing challenges4,5, because disruptions can halt power production and damage ke... | 10.1038/s41586-019-1116-4 | 30,996,348 | Nature | 2,019 | ||
Endoscopic diode laser cyclophotocoagulation with a limbal approach. | BACKGROUND AND OBJECTIVE
Endoscopic diode laser cyclophotocoagulation with a limbal approach was reviewed retrospectively. The delivery system and procedure used as well as the role of this procedure in the management of glaucoma are discussed.
PATIENTS AND METHODS
An 810-nm pulsed continuous-wave diode laser capable... | 9,054,482 | D000328:Adult; D000368:Aged; D002648:Child; D002924:Ciliary Body; D004724:Endoscopy; D005500:Follow-Up Studies; D005901:Glaucoma; D006801:Humans; D007223:Infant; D007429:Intraocular Pressure; D017075:Laser Coagulation; D016850:Limbus Corneae; D011183:Postoperative Complications; D012189:Retrospective Studies; D016896:T... | Ophthalmic surgery and lasers | 1,997 | ||
Knowledge, attitude and practices about zoonoses with reference to Campylobacteriosis in a rural area of West Bengal. | Campylobacteriosis is a leading cause of zoonotic diarrhoea in the developed as well as developing countries. Domestic animals particularly the poultry act as a source of human infections. Domestic animal rearing is a very common practice in India particularly in rural areas. The present study of KAP of Zoonosis showed... | 17,191,406 | D000818:Animals; D000829:Animals, Domestic; D002169:Campylobacter Infections; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007194:India; D012423:Rural Health; D015047:Zoonoses | Indian journal of public health | 2,006 | ||
Minor anomalies in childhood lymphomas and solid tumors. | BACKGROUND
Despite the presence of reports on correlation between major congenital defects and cancer, very few studies have investigated the frequency of minor anomalies in childhood malignancy. The aim of this study was to determine the prevalence of minor anomalies in children with lymphoma and solid tumors.
PROCE... | 10.1097/MPH.0b013e318269b40b | 23,007,416 | D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008223:Lymphoma; D008297:Male; D009369:Neoplasms; D011379:Prognosis | Journal of pediatric hematology/oncology | 2,013 | |
Understanding the process of establishing a food and nutrition policy: the case of Slovenia. | BACKGROUND
There has been an increasing effort across Europe to develop national policies in food and nutrition during the last decade. However, little is known about how public health nutrition issues get on the public health agenda and the roles individuals have when these agendas are being set.
OBJECTIVES
The aims... | 10.1016/j.healthpol.2012.06.005 | 22,771,079 | D000288:Administrative Personnel; D006077:Government Agencies; D006801:Humans; D007407:Interviews as Topic; D018673:Nutrition Policy; D011050:Policy Making; D011057:Politics; D017524:Slovenia | Health policy (Amsterdam, Netherlands) | 2,012 | |
Plastisphere in action: evidence for an interaction between expanded polystyrene and dunal plants. | Among the many threats that can be recorded on sandy beaches, plastic litter represents a serious problem for these complex and endangered ecosystems. Expanded polystyrene (EPS) is increasingly abundant as a form of plastic litter in natural environments, particularly along shores and waterways. Nevertheless, despite t... | 10.1007/s11356-017-8887-7 | 28,353,113 | D017753:Ecosystem; D004785:Environmental Pollutants; D007558:Italy; D006109:Poaceae; D011137:Polystyrenes | Environmental science and pollution research international | 2,017 | D004785:Environmental Pollutants; D011137:Polystyrenes |
Suspected botulism in foxhounds. | An outbreak of acute paralysis in a pack of foxhounds, which followed the ingestion of raw and partially cooked meat, was almost certainly due to botulism. Botulinal toxin was detected in the serum of one of three hounds which recovered, and Clostridium botulinum type C was present in a sample of meat remaining from a ... | 10.1136/vr.99.6.98 | 788,323 | D000821:Animal Feed; D000818:Animals; D001905:Botulinum Toxins; D001906:Botulism; D003014:Clostridium botulinum; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D005516:Food Microbiology; D008297:Male; D008460:Meat; D051379:Mice | The Veterinary record | 1,976 | D001905:Botulinum Toxins |
Urinary and ejaculatory dysfunction induced by denervation of specific striated muscles anatomically related to the urethra in male rats. | AIMS
The purpose of the present study was to determine the contribution of the external urethral sphincter (EUS), the ischiocavernous (IC), or the bulbospongiosus (BS) on the control of micturition, copulatory behavior and semen expulsion in male rats. We hypothesized that the EUS contributes to maintain urinary contin... | 10.1002/nau.22432 | 23,754,444 | D000818:Animals; D003307:Copulation; D003714:Denervation; D004542:Ejaculation; D008297:Male; D054792:Muscle, Striated; D051381:Rats; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal; D014521:Urethra; D014554:Urination; D014555:Urination Disorders | Neurourology and urodynamics | 2,014 | |
Validity of long-term electromyography in the quantification of tremor. | We previously developed a method of tremor quantification using long-term electromyography registration of antagonistic forearm muscles that is reliable, sensitive, and specific for pathologic tremors. The present study demonstrates that tremor occurrence as measured by this method correlates well with clinical paramet... | 10.1002/mds.870120623 | 9,399,225 | D000203:Activities of Daily Living; D000368:Aged; D004576:Electromyography; D006801:Humans; D008875:Middle Aged; D018482:Muscle, Skeletal; D010300:Parkinson Disease; D011187:Posture; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013997:Time Factors; D014202:Tremor | Movement disorders : official journal of the Movement Disorder Society | 1,997 | |
Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination. | Cdc13 performs an essential function in telomere end protection in budding yeast. Here, we analyze the consequences on telomere dynamics of cdc13-induced telomeric DNA damage in proliferating cells. Checkpoint-deficient cdc13-1 cells accumulated DNA damage and eventually senesced. However, these telomerase-proficient c... | 10.1093/emboj/20.21.6127 | 11,689,452 | D018797:Cell Cycle Proteins; D002470:Cell Survival; D016922:Cellular Senescence; D019926:Cyclin B; D004249:DNA Damage; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D018816:Genes, cdc; D009154:Mutation; D051135:Rad51 Recombinase; D051721:Rad52 DNA Repair and Recombination Protein; D011995:Recombination, Geneti... | The EMBO journal | 2,001 | D018797:Cell Cycle Proteins; D019926:Cyclin B; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; C099938:MEC3 protein, S cerevisiae; C086930:RAD50 protein, S cerevisiae; C497197:RAD52 protein, S cerevisiae; D051721:Rad52 DNA Repair and Recombination Protein; D029701:Saccharomyces cerevisiae Proteins; C428109:Stn1 ... |
The Polish adaptation of the CAMbridge Pulmonary Hypertension Outcome Review (CAMPHOR). | BACKGROUND
Pulmonary hypertension (PH) results in severely impaired quality of life (QoL) in people with this condition. The CAMbridge Pulmonary Hypertension Outcome Review (CAMPHOR) is the only questionnaire providing a disease-specific measurement of symptoms, functioning and QoL in PH patients. It has already been a... | 10.5603/CJ.a2018.0119 | 30,338,844 | D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary; D008297:Male; D017063:Outcome Assessment, Health Care; D011044:Poland; D011594:Psychometrics; D011788:Quality of Life; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires | Cardiology journal | 2,020 | |
Real-time in vitro dissolution of 5-aminosalicylic acid from single ethyl cellulose coated extrudates studied by UV imaging. | The purpose of this study was to investigate the in vitro release of 5-aminosalicylic acid from single extrudates by UV imaging and to explore the technique as a visualization tool for detecting film coating defects on extrudates coated with a thin ethyl cellulose layer. 5-Aminosalicylic acid extrudates were film coate... | 23,708,430 | D002482:Cellulose; D004339:Drug Compounding; D005079:Excipients; D019804:Mesalamine; D056951:Photoelectron Spectroscopy; D012995:Solubility | Journal of pharmaceutical and biomedical analysis | 2,013 | D005079:Excipients; D019804:Mesalamine; C013517:ethyl cellulose; D002482:Cellulose | |
Patient and operation selectivity. The peripheral vascular laboratory. | Careful use of the data from the vascular laboratory has resulted in better patient and operation selectivity in peripheral arterial disease of the lower extremities. Using the combination of segmental pressure measured with an ultrasonic Doppler and flow as approximated by the measurement of the rate of pulsatile volu... | 10.1097/00000658-197902000-00003 | 426,547 | D001157:Arterial Occlusive Diseases; D001775:Blood Circulation; D001794:Blood Pressure; D004470:Economics, Medical; D006801:Humans; D007383:Intermittent Claudication; D007511:Ischemia; D007866:Leg; D010991:Plethysmography; D010992:Plethysmography, Impedance; D014463:Ultrasonography; D014656:Vascular Surgical Procedures | Annals of surgery | 1,979 | |
Intracellular Ca2+ and Mg2+ regulation for insulin-stimulated glucose uptake into mouse diaphragm muscles. | We investigated whether the changed levels of intracellular Ca2+ and Mg2+ in mouse skeletal muscles affected insulin-stimulated glucose uptake. Insulin alone had no effect on 45Ca2+ efflux and uptake. A23187 at 20 microM increased 45Ca2+ influx and inhibited insulin-stimulated 14C-glucose uptake with normal external co... | 10.1254/jjp.56.241 | 1,881,005 | D000818:Animals; D000001:Calcimycin; D002118:Calcium; D003964:Diaphragm; D005947:Glucose; D066298:In Vitro Techniques; D007328:Insulin; D008274:Magnesium; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009132:Muscles | Japanese journal of pharmacology | 1,991 | D007328:Insulin; D000001:Calcimycin; D008274:Magnesium; D005947:Glucose; D002118:Calcium |
Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates of selection and QTL mapping. | To identify the ecological and genetic mechanisms of local adaptation requires estimating selection on traits, identifying their genetic basis, and evaluating whether divergence in adaptive traits is due to conditional neutrality or genetic trade-offs. To this end, we conducted field experiments for three years using r... | 10.1111/evo.13126 | 27,859,214 | D017360:Arabidopsis; D005075:Biological Evolution; D060146:Ecotype; D035264:Flowers; D007558:Italy; D040641:Quantitative Trait Loci; D012098:Reproduction; D012621:Seasons; D012641:Selection, Genetic; D013548:Sweden | Evolution; international journal of organic evolution | 2,017 | |
Rapamycin-loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) nanoparticles: preparation, characterization and potential application in corneal transplantation. | OBJECTIVES
Allograft rejection is the major cause of corneal graft failure. To inhibit corneal allograft rejection, rapamycin as a novel immunosuppressive agent has been discovered. However, the high water insolubility and low bioavailability of rapamycin has strongly hindered its application in the clinical setting. I... | 10.1111/jphp.12089 | 24,635,557 | D000818:Animals; D002460:Cell Line; D002626:Chemistry, Pharmaceutical; D016039:Corneal Transplantation; D016503:Drug Delivery Systems; D006084:Graft Rejection; D006801:Humans; D053758:Nanoparticles; D011091:Polyesters; D011092:Polyethylene Glycols; D020123:Sirolimus | The Journal of pharmacy and pharmacology | 2,014 | D011091:Polyesters; C492324:poly(epsilon-caprolactone)-poly(oxyethylene)-poly(epsilon-caprolactone); D011092:Polyethylene Glycols; D020123:Sirolimus |
Severe cytokine release syndrome resulting in purpura fulminans despite successful response to nivolumab therapy in a patient with pleomorphic carcinoma of the lung: a case report. | BACKGROUND
Immune checkpoint inhibitors (ICIs) have provided more options in the treatment of lung cancer. However, ICIs can cause several unfavorable reactions generally referred to as immune-related adverse effects.
CASE PRESENTATION
In this report, we present the case of a 52-year-old woman with successful regress... | 10.1186/s40425-019-0582-4 | 30,944,043 | D000074322:Antineoplastic Agents, Immunological; D015415:Biomarkers; D001780:Blood Coagulation Tests; D000080424:Cytokine Release Syndrome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms; D008875:Middle Aged; D058990:Molecular Targeted Therapy; D000077594:Nivolumab; D055665:Purpura... | Journal for immunotherapy of cancer | 2,019 | D000074322:Antineoplastic Agents, Immunological; D015415:Biomarkers; D000077594:Nivolumab |
Mycobacterium tuberculosis in Ontario, Canada: Insights from IS6110 restriction fragment length polymorphism and mycobacterial interspersed repetitive-unit-variable-number tandem-repeat genotyping. | A collection of 1,308 clinical Mycobacterium tuberculosis isolates from Ontario, Canada, was genotyped by IS6110 restriction fragment length polymorphism (RFLP) and mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) analysis. RFLP or >12 MIRU-VNTR loci were necessary for resolution of ... | 10.1128/JCM.01946-08 | 19,494,075 | D015373:Bacterial Typing Techniques; D016000:Cluster Analysis; D016172:DNA Fingerprinting; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D005838:Genotype; D006801:Humans; D018598:Minisatellite Repeats; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis; D009864:Ontario; D011110:Polymorphism... | Journal of clinical microbiology | 2,009 | D004251:DNA Transposable Elements; D004269:DNA, Bacterial |
Spatial association and clinical development of equine influenza in horses yarded overnight at an equestrian event at Maitland prior to propagating the 2007 epidemic in Australia. | The interaction and stabling of horses at equine events may have a substantial impact on the spread of a zoonotic disease. This study aimed to investigate the spread of equine influenza (EI) at an equestrian event at the start of the Australian outbreak. Around one-third of the competing horses were stabled overnight a... | 10.1111/j.1751-0813.2011.00751.x | 21,711,293 | D000818:Animals; D004196:Disease Outbreaks; D006734:Horse Diseases; D006736:Horses; D006799:Housing, Animal; D015994:Incidence; D053123:Influenza A Virus, H3N8 Subtype; D009517:New South Wales; D009976:Orthomyxoviridae Infections | Australian veterinary journal | 2,011 | |
Reduced TSH and prolactin responses to TRH in patients with panic disorder. | The authors studied the TSH and prolactin responses to a standard 500-micrograms thyrotropin-releasing hormone (TRH) stimulation test in 12 patients with panic disorder and 10 control subjects. As a group, panic disorder patients had lower mean TSH and prolactin responses, and female patients accounted for the lower pr... | 10.1176/ajp.143.4.503 | 3,082,224 | D000328:Adult; D001008:Anxiety Disorders; D003866:Depressive Disorder; D005239:Fear; D005260:Female; D006801:Humans; D008297:Male; D010200:Panic; D011388:Prolactin; D012737:Sex Factors; D013972:Thyrotropin; D013973:Thyrotropin-Releasing Hormone | The American journal of psychiatry | 1,986 | D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D013972:Thyrotropin |
[Epidemiological characteristics of HCV infected children under 15 years of age, in Henan province from 2008 to 2013]. | OBJECTIVE
To describe the epidemiological characteristics and changing trend of HCV-related children in Henan province.
METHODS
Data was analyzed based on the case-reporting records on hepatitis C from 2008 to 2013.
RESULTS
The number of reported cases and incidence of HCV-related children had increased annually fr... | 25,567,016 | D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002681:China; D002947:Cities; D005260:Female; D006526:Hepatitis C; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male | Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | 2,014 | ||
Changes in temporomandibular joint spaces after arthroscopic disc repositioning: a self-control study. | Disc repositioning is a common procedure for patients with anterior disc displacement (ADD). The purpose of this retrospective record-based study was to evaluate changes in the widths of joint spaces and condylar position changes in patients with unilateral ADD following arthroscopic disc repositioning, with the health... | 10.1038/srep45513 | 28,361,905 | D000293:Adolescent; D000328:Adult; D001182:Arthroscopy; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016059:Range of Motion, Articular; D012189:Retrospective Studies; D000068356:Self-Control; D013704:Temporomandibular Joint; D055815:Young Adult | Scientific reports | 2,017 | |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power. | Functional genomics data has the potential to increase GWAS power by identifying SNPs that have a higher prior probability of association. Here, we introduce a method that leverages polygenic functional enrichment to incorporate coding, conserved, regulatory, and LD-related genomic annotations into association analyses... | 10.1016/j.ajhg.2018.11.008 | 30,595,370 | D002138:Calibration; D030541:Databases, Genetic; D066264:Datasets as Topic; D005189:False Positive Reactions; D055106:Genome-Wide Association Study; D006801:Humans; D020412:Multifactorial Inheritance; D020641:Polymorphism, Single Nucleotide; D011336:Probability; D015203:Reproducibility of Results; D006113:United Kingdo... | American journal of human genetics | 2,019 | |
Circadian regulation of cardiac metabolism. | Circadian rhythm evolved to allow organisms to coordinate intrinsic physiological functions in anticipation of recurring environmental changes. The importance of this coordination is exemplified by the tight temporal control of cardiac metabolism. Levels of metabolites, metabolic flux, and response to nutrients all osc... | 34,338,224 | D000818:Animals; D057906:Circadian Clocks; D002940:Circadian Rhythm; D006331:Heart Diseases; D006801:Humans; D009206:Myocardium | The Journal of clinical investigation | 2,021 | ||
Rapid measurement of urinary IL-6 by ELISA: urinary IL-6 as a marker of mesangial proliferation. | To determine whether the urinary level of interleukin 6 (IL-6) measured by enzyme-linked immunosorbent assay (ELISA) can be used as a marker of mesangial proliferation, we studied urinary levels of IL-6 in 124 patients with primary and secondary glomerulonephritis, using ELISA. Although urinary levels of IL-6 were corr... | 8,107,306 | D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D002455:Cell Division; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005920:Glomerular Mesangium; D015432:Glomerulonephritis, Membranoproliferative; D006801:Humans; D015850:Interleukin-6; D008297:Male; D008875:Middle Aged | Nihon Jinzo Gakkai shi | 1,994 | D015415:Biomarkers; D015850:Interleukin-6 | |
Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection. | We have shown that calcium-activated potassium (KCa)-channels regulate fundamental progenitor-cell functions, including proliferation, but their contribution to cell-therapy effectiveness is unknown. Here, we test the participation of KCa-channels in human heart explant-derived cell (EDC) physiology and therapeutic pot... | 10.1038/s41467-021-25180-8 | 34,400,625 | D000818:Animals; D002118:Calcium; D049109:Cell Proliferation; D064987:Cell- and Tissue-Based Therapy; D016207:Cytokines; D055724:Electrophysiological Phenomena; D005786:Gene Expression Regulation; D006321:Heart; D006801:Humans; D051660:Intermediate-Conductance Calcium-Activated Potassium Channels; D007511:Ischemia; D00... | Nature communications | 2,021 | D016207:Cytokines; D051660:Intermediate-Conductance Calcium-Activated Potassium Channels; C496923:KCNN4 protein, human; C496925:Kcnn4 protein, mouse; D026902:Potassium Channel Blockers; D024681:Potassium Channels, Calcium-Activated; D011188:Potassium; D002118:Calcium |
Studies on Mediterranean leishmaniasis: V.A. preliminary epidemiological survey of human leishmaniasis in Tuscany. | Leishmanin skin testing was performed on 1,285 people in the Tuscany region of Italy. In a known endemic area for leishmaniasis there was an increasing positivity with age, while in another area the curve was bell-shaped suggesting an interruption of transmission in the recent past. In all areas the positivity rate for... | 10.1016/0035-9203(77)90212-7 | 871,035 | D000367:Age Factors; D005260:Female; D006801:Humans; D007558:Italy; D007896:Leishmaniasis; D007898:Leishmaniasis, Visceral; D008297:Male; D012737:Sex Factors; D012882:Skin Tests | Transactions of the Royal Society of Tropical Medicine and Hygiene | 1,977 | |
Co-infection with Enterobius vermicularis and Taenia saginata mimicking acute appendicitis. | In this report, we describe an unusual case of verminous appendicitis due to Enterobius vermicularis and Taenia saginata in a 29-year-old woman from Iran. The histopathological examinations and parasitological descriptions of both worms found in the appendix lumen are discussed. The removed appendix exhibited the macro... | 26,754,203 | D000328:Adult; D000818:Animals; D000871:Anthelmintics; D001064:Appendicitis; D060085:Coinfection; D017229:Enterobiasis; D004757:Enterobius; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007492:Iran; D008463:Mebendazole; D011223:Praziquantel; D041202:Taenia saginata; D013622:Taeniasis; D016896:Treatment O... | Journal of infection and public health | 2,016 | D000871:Anthelmintics; D011223:Praziquantel; D008463:Mebendazole | |
Composite Microparticles Based on Natural Mucoadhesive Polymers with Promising Structural Properties to Protect and Improve the Antifungal Activity of Miconazole Nitrate. | Oropharyngeal candidiasis is a recurrent oral infection caused by Candida species. Gel formulation containing miconazole nitrate is the most common approach for treating oral candidiasis. However, traditional oral topical antifungal therapies have many limitations, including short contact time with the oral mucosa and ... | 10.1208/s12249-018-1175-0 | 30,238,304 | D000935:Antifungal Agents; D002176:Candida albicans; D048271:Chitosan; D004339:Drug Compounding; D008825:Miconazole; D011108:Polymers | AAPS PharmSciTech | 2,018 | D000935:Antifungal Agents; D011108:Polymers; D008825:Miconazole; D048271:Chitosan |
Does Insomnia Exist without Hyperarousal? What Else Can There Be? | While in ancient Greece, incubation rooms were dedicated to the interpretation of dreams, sleep was also studied by famous philosophers such as Aristotle. In 350 B.C.E., he wrote an essay titled "On Sleep and Sleepiness". (...). | 10.3390/brainsci10040225 | 32,290,107 | Brain sciences | 2,020 | ||
Using Intervention Mapping methodology to design an HIV linkage intervention in a refugee settlement in rural Uganda. | Nearly 80 million people have been forcibly displaced by persecution, violence, and disaster. Displaced populations, including refugees, face health challenges such as resource shortages, food and housing insecurity, violence, and disrupted social support. People living with HIV in refugee settings have decreased engag... | 10.1080/09540121.2021.1900532 | 33,749,418 | D015658:HIV Infections; D006801:Humans; D012036:Refugees; D057545:Social Stigma; D014454:Uganda | AIDS care | 2,022 | |
Intraindividual comparison of human radial and internal thoracic arteries in vitro and the effect of preoperative calcium blocker therapy. | The patency rate of radial artery (RA) conduits is considerably lower than that of internal thoracic artery (ITA) grafts and the evidence suggests that this is due to a clinically suspected higher incidence of vasospasm. The aim of this study was, therefore, to compare intraindividually the pharmacological reactivity o... | 10.1111/j.1472-8206.2006.00452.x | 17,227,446 | D000317:Adrenergic alpha-Antagonists; D000368:Aged; D002121:Calcium Channel Blockers; D002122:Calcium Chloride; D065130:Endothelin A Receptor Antagonists; D065131:Endothelin B Receptor Antagonists; D019332:Endothelin-1; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008323:Mammary Arteries;... | Fundamental & clinical pharmacology | 2,007 | D000317:Adrenergic alpha-Antagonists; D002121:Calcium Channel Blockers; D065130:Endothelin A Receptor Antagonists; D065131:Endothelin B Receptor Antagonists; D019332:Endothelin-1; D009842:Oligopeptides; D010456:Peptides, Cyclic; D010880:Piperidines; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B; D01466... |
Statistical ensemble inequivalence for flexible polymers under confinement in various geometries. | The problem of statistical ensemble inequivalence for single polymers has been the subject of intense research. In a recent publication, we show that even though the force-extension relation of a free Gaussian chain exhibits ensemble equivalence, confinement to half-space due to tethering to a planar substrate induces ... | 10.1039/c9sm02246e | 32,016,271 | Soft matter | 2,020 | ||
[Participation of pancreatic ribonuclease in the digestion processes]. | The authors purified the alkaline ribonuclease obtained from the pancreas and the contents of the superior part of the dog's intestine. A comparative examination of physico-chemical properties and specificity of the separated enzymes was effected. The resulting data prove the pancreas to be the source of the alkaline r... | 15,345 | D000818:Animals; D002845:Chromatography; D004063:Digestion; D004285:Dogs; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007419:Intestinal Secretions; D010179:Pancreas; D012313:RNA; D012260:Ribonucleases; D013696:Temperature | Voprosy pitaniia | 1,976 | D012313:RNA; D012260:Ribonucleases | |
Virtual screening of HIV-1 protease inhibitors against human cytomegalovirus protease using docking and molecular dynamics. | The clearance of cytomegalovirus viraemia in HIV-1-infected patients may partly result from the inhibition of cytomegalovirus protease by HIV-1 protease inhibitors contained in highly active antiretroviral therapy. We used a computational method to calculate the binding affinity of six HIV-1 protease inhibitors to cyto... | 10.1097/01.aids.0000162343.96674.4c | 15,764,860 | D017088:AIDS-Related Opportunistic Infections; D023241:Antiretroviral Therapy, Highly Active; D001665:Binding Sites; D002219:Carbamates; D018360:Crystallography, X-Ray; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections; D005663:Furans; D015658:HIV Infections; D017320:HIV Protease Inhibitors; D015497:HIV-1; D0... | AIDS (London, England) | 2,005 | D002219:Carbamates; D005663:Furans; D017320:HIV Protease Inhibitors; D013449:Sulfonamides; C095108:amprenavir; D019469:Indinavir; D010447:Peptide Hydrolases |
Quality of care indicators for prostate cancer: progress toward consensus. | Previously-documented variations in patterns of care and patient outcomes suggest differences in the quality of care provided to men with prostate cancer. Herein we describe ongoing efforts to measure the quality of prostate cancer care, including the development and pilot-testing of the RAND prostate cancer quality in... | 10.1016/j.urolonc.2009.01.011 | 19,573,774 | D006801:Humans; D008297:Male; D008495:Medical Oncology; D017063:Outcome Assessment, Health Care; D011471:Prostatic Neoplasms; D011785:Quality Assurance, Health Care; D019984:Quality Indicators, Health Care; D011787:Quality of Health Care; D012952:Societies; D014481:United States | Urologic oncology | 2,009 | |
Associations between multiple pregnancies and health risk behaviors among U.S. adolescents. | PURPOSE
This study examined the associations between health risk behaviors (i.e., substance use behaviors, physical violence, or carried a weapon) and multiple adolescent pregnancies (i.e., experiencing or causing more than one pregnancy).
METHODS
We analyzed 1999-2003 data (3 years: 1999, 2001, and 2003) from the Na... | 10.1016/j.jadohealth.2010.03.018 | 21,094,438 | D000293:Adolescent; D000294:Adolescent Behavior; D016497:Adolescent Health Services; D005260:Female; D015438:Health Behavior; D006801:Humans; D007398:Interpersonal Relations; D010379:Peer Group; D011247:Pregnancy; D011253:Pregnancy in Adolescence; D012309:Risk-Taking; D012649:Self Concept; D019966:Substance-Related Dis... | The Journal of adolescent health : official publication of the Society for Adolescent Medicine | 2,010 | |
Association of Ang-(1-7) and des-Arg9BK as new biomarkers of obesity and cardiometabolic risk factors in adolescents. | Children with obesity have a high risk of developing cardiovascular disease and hypertension, which is associated with the renin-angiotensin system (RAS) activation and kallikrein-kinin system (KKS) inactivation. Although recent studies have identified several peptide-based biomarkers for obesity, circulating peptides ... | 10.1038/s41440-021-00618-0 | 33,568,792 | D000293:Adolescent; D015415:Biomarkers; D001920:Bradykinin; D000083202:Cardiometabolic Risk Factors; D002648:Child; D006801:Humans; D009767:Obesity, Morbid; D063766:Pediatric Obesity | Hypertension research : official journal of the Japanese Society of Hypertension | 2,021 | D015415:Biomarkers; D001920:Bradykinin |
Assessment of infant growth. | Growth is one of the best indicators of neonatal and infant well being. By comparing the growth of an individual infant over a period of time with available standards, the determination can be made, within limitations, whether the infant is doing as well as should be expected or whether any growth abnormalities exist. ... | 10.1016/0891-5245(92)90096-m | 1,453,285 | D002675:Child, Preschool; D006130:Growth Disorders; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D017283:Neonatal Nursing; D009730:Nursing Assessment; D010371:Pediatric Nursing; D012307:Risk Factors | Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners | 1,992 | |
An autoradiographic study of the distribution of binding sites for the novel alpha7-selective nicotinic radioligand [3H]-methyllycaconitine in the mouse brain. | [3H]-Methyllycaconitine ([3H]-MLA) is a new radioligand with selectivity for alpha7-type neuronal nicotinic acetylcholine receptors (nAChRs). In our previous study [Davies, A.R.L., Hardick, D.J., Blagbrough, I.S., Potter, B.V.L., Wolstenholme, A.J. & Wonnacott, S. (1999) Neuropharmacology, 38, 679-690], this radioligan... | 10.1046/j.1460-9568.1999.00685.x | 10,457,165 | D000157:Aconitine; D000818:Animals; D001345:Autoradiography; D001665:Binding Sites; D001921:Brain; D002038:Bungarotoxins; D007457:Iodine Radioisotopes; D008024:Ligands; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011978:Receptors, Nicotinic; D014018:Tissue Distribution; D014316:Tritium | The European journal of neuroscience | 1,999 | D002038:Bungarotoxins; D007457:Iodine Radioisotopes; D008024:Ligands; D011978:Receptors, Nicotinic; D014316:Tritium; C054634:methyllycaconitine; D000157:Aconitine |
Functional analysis of the sortase YhcS in Bacillus subtilis. | Sortases of Gram-positive bacteria catalyze the covalent C-terminal anchoring of proteins to the cell wall. Bacillus subtilis, a well-known host organism for protein production, contains two putative sortases named YhcS and YwpE. The present studies were aimed at investigating the possible sortase function of these pro... | 10.1002/pmic.201100174 | 21,800,427 | D000595:Amino Acid Sequence; D019881:Aminoacyltransferases; D001412:Bacillus subtilis; D001426:Bacterial Proteins; D002473:Cell Wall; D002688:Chitinases; D003546:Cysteine Endopeptidases; D008969:Molecular Sequence Data; D009154:Mutation; D010710:Phosphates | Proteomics | 2,011 | D001426:Bacterial Proteins; D010710:Phosphates; D019881:Aminoacyltransferases; D002688:Chitinases; D003546:Cysteine Endopeptidases |
Phase Variation of LPS and Capsule Is Responsible for Stochastic Biofilm Formation in Francisella tularensis. | Biofilms have been established as an important lifestyle for bacteria in nature as these structured communities often enable survivability and persistence in a multitude of environments. Francisella tularensis is a facultative intracellular Gram-negative bacterium found throughout much of the northern hemisphere. Howev... | 10.3389/fcimb.2021.808550 | 35,096,655 | D018441:Biofilms; D005603:Francisella; D005604:Francisella tularensis; D006801:Humans; D008070:Lipopolysaccharides; D000090502:Phase Variation; D014406:Tularemia | Frontiers in cellular and infection microbiology | 2,021 | D008070:Lipopolysaccharides |
The Family Experience with Eating Disorders Scale: psychometric analysis. | The role of the family in the development and maintenance of eating disorders is frequently cited in the literature; however, common methodological issues, including the use of diverse family assessment instruments with inadequate psychometric properties, exist. Further, variables specific to families with eating disor... | 10.1016/j.apnu.2007.04.003 | 17,673,113 | D000328:Adult; D017281:Cost of Illness; D005190:Family; D005192:Family Health; D001068:Feeding and Eating Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011594:Psychometrics; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires | Archives of psychiatric nursing | 2,007 | |
Structure, vibrational, and optical properties of platinum cluster: a density functional theory approach. | Using density functional theory, stability, chemical, and optical properties of small platinum clusters, Ptn (n = 2 to 10) have been investigated. An attempt has been made to establish a correlation between stability and chemical reactivity parameters. The calculated geometries are in agreement with the available exper... | 10.1007/s00894-014-2537-5 | 25,451,143 | Journal of molecular modeling | 2,014 | ||
High β-Glucans Oats for Healthy Wheat Breads: Physicochemical Properties of Dough and Breads. | Bread is a highly consumed food whose nutritional value can be improved by adding an oat flour (Avena sativa L.-variety Bonaerense INTA Calen-Argentina) to a high-industrial quality wheat flour (Triticum aestivum L.). This cultivar of oat contains high amounts of β-glucans, which act as a prebiotic fiber. Wheat flour w... | 10.3390/foods12010170 | 36,613,386 | Foods (Basel, Switzerland) | 2,022 | ||
[Forensic chemical testing of cadaveric material for acetonitrile]. | Gas chromatographic conditions for qualitative and quantitative evaluation of acetonitrile in biological material were determined, including those for reactive gas chromatography. Absolute and relative time of acetonitrile and concomitant substances retention in three columns of different polarity was determined. Study... | 11,561,518 | D000097:Acetonitriles; D002102:Cadaver; D002423:Cause of Death; D002849:Chromatography, Gas; D005554:Forensic Medicine; D006801:Humans | Sudebno-meditsinskaia ekspertiza | 2,001 | D000097:Acetonitriles; C032159:acetonitrile | |
Automatic captioning for medical imaging (MIC): a rapid review of literature. | Automatically understanding the content of medical images and delivering accurate descriptions is an emerging field of artificial intelligence that combines skills in both computer vision and natural language processing fields. Medical image captioning is involved in various applications related to diagnosis, treatment... | 10.1007/s10462-022-10270-w | 36,160,365 | Artificial intelligence review | 2,023 | ||
Skin toxicity during breast irradiation: pathophysiology and management. | Radiotherapy is a critical component in the treatment of breast cancer, a disease that is estimated to have affected 203,500 US women in 2002. According to the data from some series, an estimated 90% of patients treated with radiotherapy for breast cancer will develop a degree of radiation-induced dermatitis. This revi... | 10.1097/01.SMJ.0000140866.97278.87 | 15,558,927 | D001943:Breast Neoplasms; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D011855:Radiodermatitis; D012720:Severity of Illness Index | Southern medical journal | 2,004 | |
[Human leukocyte antigen mismatched hemopietic stem cell transplants for the treatment of leukemia]. | OBJECTIVE
To explore the feasibility of HLA mismatched hemopietic stem cell transplants for the treatment of leukemia.
METHODS
Between July 2000 and December 2001, seven patients received hemopietic stem cell transplants(HSCT) with HLA mismatched family donors, including 3 chronic myelocytic leukemia (CML), 3 acute n... | 12,920,822 | D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide; D016572:Cyclosporine; D006086:Graft vs Host Disease; D016179:Granulocyte Colony-Stimulating Factor; D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D015470:Leukemi... | Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences | 2,003 | D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II; D016179:Granulocyte Colony-Stimulating Factor; D016572:Cyclosporine; D003520:Cyclophosphamide; D009173:Mycophenolic Acid; D008727:Methotrexate | |
Adult pulmonary tuberculosis as a pathological manifestation of hyperactive antimycobacterial immune response. | The intricate relationship between tuberculosis (TB) and immune system remains poorly understood. It is generally believed that weakening of the immune response against Mycobacterium tuberculosis leads to reactivation of latent infection into the active pulmonary disease. However, heterogeneous nature of TB and failure... | 10.1186/s40169-016-0119-0 | 27,709,522 | Clinical and translational medicine | 2,016 | ||
E-cigarettes and Smoking Cessation in the United States According to Frequency of E-cigarette Use and Quitting Duration: Analysis of the 2016 and 2017 National Health Interview Surveys. | INTRODUCTION
The purpose of this study was to examine the association between electronic cigarette (e-cigarette) use and smoking cessation among US adults. Duration of smoking cessation was taken into consideration because e-cigarette awareness and use were low in the United States before 2010.
METHODS
A pooled analy... | 10.1093/ntr/ntz025 | 30,768,136 | D000293:Adolescent; D000328:Adult; D000465:Algorithms; D003430:Cross-Sectional Studies; D066300:Electronic Nicotine Delivery Systems; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D000074285:Smokers; D012907:Smoking; D016540:Smoking Cessation; D011795:Surveys and Questionnaires;... | Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco | 2,020 | |
Nonlinear Viscoelasticity and Generalized Failure Criterion for Polymer Gels. | Polymer gels behave as soft viscoelastic solids and exhibit a generic nonlinear mechanical response characterized by pronounced stiffening prior to irreversible failure, most often through macroscopic fractures. Here, we describe this scenario for a model protein gel using an integral constitutive equation built upon t... | 10.1021/acsmacrolett.7b00213 | 35,650,868 | ACS macro letters | 2,017 | ||
Acute respiratory failure caused by leukaemic infiltration of the lung of a dog. | A seven-year-old crossbred male dog with a suspected leukaemic condition was referred for investigation and treatment. A bone marrow aspirate revealed an acute myeloid leukaemia. Combination chemotherapy was administered and the dog initially improved, but 18 days after the initiation of therapy its body condition dete... | 10.1111/j.1748-5827.2001.tb02472.x | 11,480,902 | D000818:Animals; D001854:Bone Marrow Cells; D003645:Death, Sudden; D003937:Diagnosis, Differential; D004283:Dog Diseases; D004285:Dogs; D007951:Leukemia, Myeloid; D017254:Leukemic Infiltration; D008168:Lung; D008297:Male; D012131:Respiratory Insufficiency | The Journal of small animal practice | 2,001 | |
Neural activity, alertness and visual orientation in intact and unilaterally labyrinthectomized rabbits. | Electrical brain activity and eye movements were recorded in 10 intact and 6 unilaterally labyrinthectomized rabbits, each with implanted electrodes. The frequency of optokinetic nystagmus (OKN) and a 10-second aggregate of theta waves in the dorsal hippocampus were determined after exposure of the animals to sound, vi... | 10.1159/000275903 | 3,561,969 | D000161:Acoustic Stimulation; D000818:Animals; D007758:Ear, Inner; D004569:Electroencephalography; D006624:Hippocampus; D009760:Nystagmus, Physiologic; D009949:Orientation; D011817:Rabbits; D014732:Vibration | ORL; journal for oto-rhino-laryngology and its related specialties | 1,987 | |
Presence of Rickettsia conorii subsp. israelensis, the causative agent of Israeli spotted fever, in Sicily, Italy, ascertained in a retrospective study. | A retrospective analysis by molecular-sequence-based techniques was performed to correctly identify the etiological agent of 24 Mediterranean spotted fever cases occurring in Western Sicily, Italy, from 1987 to 2001. Restriction analysis of a 632-bp PCR-amplified portion of the ompA gene allowed presumptive identificat... | 10.1128/JCM.43.12.6027-6031.2005 | 16,333,093 | D000328:Adult; D000368:Aged; D001425:Bacterial Outer Membrane Proteins; D001907:Boutonneuse Fever; D005260:Female; D006801:Humans; D007557:Israel; D007558:Italy; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D012189:Retrospective Studies; D020114:Rickettsia conorii; D017422:Sequence Analysis, DNA | Journal of clinical microbiology | 2,005 | D001425:Bacterial Outer Membrane Proteins; C078167:OMPA outer membrane proteins |
Understanding the Psychopathic Personality Inventory (PPI) in terms of the unidimensionality, orthogonality, and construct validity of PPI-I and -II. | Comments on an article by Marcus et al. (see record 2011-23134-001). Marcus et al. (this issue) hold that PPI-I and PPI-II are generally orthogonal (uncorrelated). Examination of the primary PPI scales calls this into question. Specifically, the scales that make up Psychopathic Personality Inventory (PPI)-I and PPI-II ... | 10.1037/a0027196 | 23,339,315 | D000987:Antisocial Personality Disorder; D006801:Humans; D007175:Impulsive Behavior; D008960:Models, Psychological; D010555:Personality Inventory; D012930:Social Dominance | Personality disorders | 2,013 | |
Vitamin D resistance in chronic kidney disease (CKD). | BACKGROUND
Previous studies have shown that treatment with ergocalciferol in patients with CKD stage 3 + 4 is not effective with less than 33% of patients achieving a 25-OH vitamin D target of >30 ng/ml. The aim of this study was to test the response to cholecalciferol in CKD. We attempted to replete 25-OH vitamin D to... | 10.1186/1471-2369-15-47 | 24,641,586 | D000368:Aged; D004351:Drug Resistance; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic; D016896:Treatment Outcome; D014807:Vitamin D; D014808:Vitamin D Deficiency; D014815:Vitamins | BMC nephrology | 2,014 | D014815:Vitamins; D014807:Vitamin D |
Phenotypic variability and neuropsychological findings associated with C9orf72 repeat expansions in a Bulgarian dementia cohort. | BACKGROUND
The GGGGCC repeat expansion in the C9orf72 gene was recently identified as a major cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in several European populations. The objective of this study was to determine the frequency of C9orf72 repeat expansions in a Bulgarian dementia co... | 10.1371/journal.pone.0208383 | 30,550,541 | D000368:Aged; D002031:Bulgaria; D000073885:C9orf72 Protein; D042622:DNA Repeat Expansion; D003704:Dementia; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D016133:Polymerase Chain Reaction | PloS one | 2,018 | D000073885:C9orf72 Protein |
Constructed wetlands for textile wastewater remediation: A review on concept, pollutant removal mechanisms, and integrated technologies for efficiency enhancement. | Textile industries are among the ecologically unsustainable industries that release voluminous wastewater threatening ecosystem health. The constructed wetlands (CWs) are low-cost eco-technological interventions for the management of industrial wastewaters. The CWs are self-sustaining remediation systems that do not re... | 10.1016/j.chemosphere.2021.133358 | 34,929,266 | D017753:Ecosystem; D004785:Environmental Pollutants; D013672:Technology; D013784:Textiles; D014865:Waste Disposal, Fluid; D062065:Wastewater; D053833:Wetlands | Chemosphere | 2,022 | D004785:Environmental Pollutants; D062065:Waste Water |
Cannabis in patients with Parkinson's disease in Argentina. A cross sectional study. | We made an observational cross-sectional study to evaluate the prevalence of cannabis use, characteristics and results perceived by a group of PD patients. Semi-structured questionnaire was applied to patients. Until obtaining more information we suggest to incorporate into regular medical practice the question about t... | 10.1016/j.parkreldis.2020.06.033 | 32,739,838 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001118:Argentina; D063385:Cannabinoid Receptor Modulators; D003430:Cross-Sectional Studies; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D064086:Medical Marijuana; D008875:Middle Aged; D017063:Outcome Assessment, He... | Parkinsonism & related disorders | 2,020 | D063385:Cannabinoid Receptor Modulators; D064086:Medical Marijuana |
Deep learning-based ensemble modeling of Vibrio parahaemolyticus concentration in marine environment. | Vibrio parahaemolyticus (V.p) is a marine pathogenic bacterium that poses a high risk to human health and shellfish industry, yet an effective regional-scale nowcasting model for managing the risk remains lacking. This study presents the first regional-scale model for nowcasting the level of V.p in oysters in the marin... | 10.1007/s10661-022-10836-9 | 36,565,404 | D000818:Animals; D006801:Humans; D014736:Vibrio parahaemolyticus; D000077321:Deep Learning; D004784:Environmental Monitoring; D010125:Ostreidae; D012758:Shellfish | Environmental monitoring and assessment | 2,022 | |
Inhibition of NOX2-NLRP1 signaling pathway protects against chronic glucocorticoids exposure-induced hippocampal neuronal damage. | Glucocorticoids (GCs) exposure has deleterious alteration on the structure and function in hippocampal neurons. NADPH oxidase 2 (NOX2) is a major contributor to oxidative stress in neurological diseases, and NLRP1 inflammasome can be activated in response to oxidative stress. We hypothesize that inhibition of NOX2-medi... | 10.1016/j.intimp.2019.105721 | 31,255,881 | D048868:Adaptor Proteins, Signal Transducing; D000544:Alzheimer Disease; D000818:Animals; D051017:Apoptosis Regulatory Proteins; D001522:Behavior, Animal; D003907:Dexamethasone; D004195:Disease Models, Animal; D064420:Drug-Related Side Effects and Adverse Reactions; D004781:Environmental Exposure; D006624:Hippocampus; ... | International immunopharmacology | 2,019 | D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; C529636:NALP1 protein, mouse; D034741:RNA, Small Interfering; D003907:Dexamethasone; D000074662:NADPH Oxidase 2 |
Immunodiagnosis of meningeal leukemia using the alkaline phosphatase procedure. | To optimalize the diagnosis of meningeal involvement in ALL we adapted the alkaline-phosphatase-anti-alkaline-phosphatase procedure (APAAP) to be used for cerebrospinal fluid (CSF) examination. The study was performed on 19 patients (9 children with leukemia) with CSF hypercellularity. 490 determinations with a panel o... | 3,077,243 | D000469:Alkaline Phosphatase; D000911:Antibodies, Monoclonal; D006801:Humans; D007124:Immunoenzyme Techniques; D008577:Meningeal Neoplasms; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma | Archivum immunologiae et therapiae experimentalis | 1,988 | D000911:Antibodies, Monoclonal; D000469:Alkaline Phosphatase | |
Microbial Community Successional Changes in a Full-Scale Mesophilic Anaerobic Digester from the Start-Up to the Steady-State Conditions. | Anaerobic digestion is a widely used technology for sewage sludge stabilization and biogas production. Although the structure and composition of the microbial communities responsible for the process in full-scale anaerobic digesters have been investigated, little is known about the microbial successional dynamics durin... | 10.3390/microorganisms9122581 | 34,946,180 | Microorganisms | 2,021 | ||
Mitochondrial Ca2+ and Reactive Oxygen Species in Trypanosomatids. | Millions of people are infected with trypanosomatids and new therapeutic approaches are needed. Trypanosomatids possess one mitochondrion per cell and its study has led to discoveries of general biological interest. These mitochondria, as in their animal counterparts, generate reactive oxygen species (ROS) and have evo... | 10.1089/ars.2021.0058 | 34,218,689 | D000818:Animals; D002118:Calcium; D045304:Cytochromes c; D006801:Humans; D008322:Mammals; D008928:Mitochondria; D000083162:Mitochondrial Permeability Transition Pore; D017382:Reactive Oxygen Species | Antioxidants & redox signaling | 2,022 | D000083162:Mitochondrial Permeability Transition Pore; D017382:Reactive Oxygen Species; D045304:Cytochromes c; D002118:Calcium |
Regulation of glucose uptake in fast and slow skeletal muscles with fasting and refeeding. | 1. The decrease in wet weight and noncollagen protein (NCP) was faster and greater in extensor digitorum longus (EDL) during fasting than in soleus (Sol) muscles in rats. 2. During refeeding, recovery was completed faster in Sol than in EDL. 3. Glucose uptake in skeletal muscle increased significantly during fasting on... | 10.1016/0300-9629(91)90586-2 | 1,673,369 | D000818:Animals; D001835:Body Weight; D004435:Eating; D004734:Energy Metabolism; D005215:Fasting; D005260:Female; D005947:Glucose; D009132:Muscles; D051381:Rats; D011919:Rats, Inbred Strains; D012588:Scintillation Counting | Comparative biochemistry and physiology. A, Comparative physiology | 1,991 | D005947:Glucose |
Lipid transfer proteins and protease inhibitors as key factors in the priming of barley responses to Fusarium head blight disease by a biocontrol strain of Pseudomonas fluorescens. | Strains of non-pathogenic pseudomonad bacteria, can elicit host defence responses against pathogenic microorganisms. Pseudomonas fluorescens strain MKB158 can protect cereals from pathogenesis by Fusarium fungi, including Fusarium head blight which is an economically important disease due to its association with both y... | 10.1007/s10142-010-0177-0 | 20,526,726 | D002352:Carrier Proteins; D005670:Fusarium; D018506:Gene Expression Regulation, Plant; D001467:Hordeum; D046228:Microarray Analysis; D008969:Molecular Sequence Data; D010572:Pest Control, Biological; D010935:Plant Diseases; D011480:Protease Inhibitors; D011551:Pseudomonas fluorescens | Functional & integrative genomics | 2,010 | D002352:Carrier Proteins; D011480:Protease Inhibitors; C030363:lipid transfer protein |
The economic recession: early impacts on health care safety net providers. | While the recession increased demands on the health care safety net as Americans lost jobs and health insurance, the impact on safety net providers has been mixed and less severe--at least initially--than expected in some cases, according to a new study of five metropolitan communities by the Center for Studying Health... | 20,425,933 | D057171:American Recovery and Reinvestment Act; D002017:Budgets; D003151:Community Health Centers; D057172:Economic Recession; D004632:Emergency Medical Services; D004636:Emergency Service, Hospital; D005544:Forecasting; D006301:Health Services Needs and Demand; D006801:Humans; D009111:Local Government; D008483:Medical... | Research brief | 2,010 | ||
Intraperitoneal delivery of acetate-encapsulated liposomal nanoparticles for neuroprotection of the penumbra in a rat model of ischemic stroke. | BACKGROUND
Ischemic stroke is a devastating condition, with metabolic derangement and persistent inflammation enhancing the initial insult of ischaemia. Recombinant tissue plasminogen remains the only effective treatment but limited as therapy must commence soon after the onset of symptoms.
PURPOSE
We investigated wh... | 10.2147/IJN.S193965 | 30,936,698 | D000085:Acetates; D000818:Animals; D017209:Apoptosis; D001921:Brain; D002545:Brain Ischemia; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D020244:Infarction, Middle Cerebral Artery; D008081:Liposomes; D008279:Magnetic Resonance Imaging; D008297:Male; D053758:Nanoparticles; D055495:Neurogenesis; D01869... | International journal of nanomedicine | 2,019 | D000085:Acetates; D008081:Liposomes; D018696:Neuroprotective Agents |
Some proteins not belonging to the clotting or to the kallikrein-kinin system altered by kallikrein. | Plasma kallikrein activation occurs frequently during blood drawing and subsequent plasma handling. The purified enzyme was incubated with ceruloplasmin, inter-alpha-trypsin inhibitor and complement factor C4. Proteolysis caused by this enzyme was compared with the degradative effects of plasmin and thrombin. Among the... | 10.1515/bchm2.1983.364.1.651 | 6,224,732 | D001777:Blood Coagulation; D001798:Blood Proteins; D002352:Carrier Proteins; D002570:Ceruloplasmin; D003181:Complement C4; D003169:Complement Inactivator Proteins; D005341:Fibrinolysin; D016167:Integrin alphaXbeta2; D007610:Kallikreins; D007705:Kinins; D013917:Thrombin | Hoppe-Seyler's Zeitschrift fur physiologische Chemie | 1,983 | D001798:Blood Proteins; D002352:Carrier Proteins; D003181:Complement C4; D003169:Complement Inactivator Proteins; D016167:Integrin alphaXbeta2; D007705:Kinins; D002570:Ceruloplasmin; D007610:Kallikreins; D013917:Thrombin; D005341:Fibrinolysin |
Definitive treatment of traumatic biliary injuries. | BACKGROUND
We presented our experience with definitive treatment of traumatic biliary injuries.
METHODS
Six male patients (mean age 13 years; range 2 to 32 years) who were referred to our unit for definitive treatment of traumatic biliary injuries were retrospectively evaluated. Data were analyzed in terms of demogra... | 15,497,059 | D000293:Adolescent; D000328:Adult; D001658:Biliary Fistula; D002648:Child; D002675:Child, Preschool; D006801:Humans; D015601:Injury Severity Score; D008099:Liver; D008297:Male; D008499:Medical Records; D011183:Postoperative Complications; D012189:Retrospective Studies; D014421:Turkey; D014949:Wounds, Nonpenetrating; D0... | Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES | 2,004 | ||
Dustfall-bound polycyclic aromatic hydrocarbons (PAHs) over the fifth largest Chinese lake: residual levels, source apportionment, and correlations with suspended particulate matter (SPM)-bound PAHs in water. | Residual levels and temporal-spatial distribution characteristics of polycyclic aromatic hydrocarbons (PAHs) in dustfall were studied at the seasonal scale between June 2010 and May 2011 in the fifth largest shallow lake in China. PAHs flux of atmospheric deposition and the impact on the PAHs in the lake water column w... | 10.1007/s11356-021-14873-8 | 34,132,961 | D002681:China; D060106:Lakes; D052638:Particulate Matter; D011084:Polycyclic Aromatic Hydrocarbons; D014867:Water | Environmental science and pollution research international | 2,021 | D052638:Particulate Matter; D011084:Polycyclic Aromatic Hydrocarbons; D014867:Water |
Unusual RNA polymerase content of Trypanosoma brucei nuclei. | Nuclei were isolated from bloodstream forms of Trypanosoma brucei by nitrogen cavitation and sedimentation through percoll density gradients. Transcription studies with these nuclei in vitro demonstrated features not seen with other eukaryotes: RNA synthesis was much greater in the presence of Mn2+ than with Mg2+ and w... | 10.1016/0006-291x(85)91316-6 | 2,413,850 | D000546:Amanitins; D000645:Ammonium Sulfate; D000818:Animals; D002458:Cell Fractionation; D002467:Cell Nucleus; D012321:DNA-Directed RNA Polymerases; D003609:Dactinomycin; D003850:Deoxyribonuclease I; D008274:Magnesium; D008345:Manganese; D051379:Mice; D009994:Osmolar Concentration; D012313:RNA; D051381:Rats; D012259:R... | Biochemical and biophysical research communications | 1,985 | D000546:Amanitins; D003609:Dactinomycin; D008345:Manganese; D012313:RNA; D012321:DNA-Directed RNA Polymerases; D003850:Deoxyribonuclease I; D012259:Ribonuclease, Pancreatic; D008274:Magnesium; D000645:Ammonium Sulfate |
Canine PKD1 is a single-copy gene: genomic organization and comparative analysis. | Most cases of autosomal dominant polycystic kidney disease are caused by mutations in the gene PKD1, encoding polycystin-1. To gain insight into the role of polycystin-1 in tubulogenesis and cystogenesis using the well-characterized canine kidney epithelial cell line MDCK, we have now cloned and characterized the exon/... | 10.1006/geno.2002.6804 | 12,079,289 | D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D003001:Cloning, Molecular; D004285:Dogs; D005091:Exons; D018628:Gene Dosage; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D011506:Proteins; D012091:Repetitive Sequences, Nucleic Acid; D017422:Sequence Analysis, DNA; D020539:Sequence ... | Genomics | 2,002 | D011506:Proteins; D050396:TRPP Cation Channels; C087882:polycystic kidney disease 1 protein |
Genetic diagnostics of functional variants of the human dopamine D2 receptor gene. | INTRODUCTION
The importance of dopamine D2 receptors (DRD2) for central nervous dopaminergic signalling makes variants in the DRD2 gene potential modulators of the risk or course of various behavioural, psychiatric or neurologic diseases (e.g. addiction, schizophrenia, Parkinson's disease). We developed Pyrosequencing ... | 10.1097/YPG.0b013e32832d0941 | 19,512,960 | D001483:Base Sequence; D005091:Exons; D005787:Gene Frequency; D006801:Humans; D008969:Molecular Sequence Data; D009422:Nervous System Diseases; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases; D017448:Receptors, Dopamine D2; D017422:Sequence Analysis, DNA | Psychiatric genetics | 2,009 | D017448:Receptors, Dopamine D2; C489948:ANKK1 protein, human; D017346:Protein Serine-Threonine Kinases |
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