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Probiotic therapy for the treatment of spondyloarthritis: a randomized controlled trial. | OBJECTIVE
To investigate the effect of an orally administered probiotic on disease activity, fatigue, quality of life, and intestinal symptoms in patients with active spondyloarthritis.
METHODS
Patients with active spondyloarthritis [defined as Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≥ 3, Bath Ank... | 10.3899/jrheum.100193 | 20,716,665 | D000328:Adult; D000368:Aged; D000818:Animals; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D019936:Probiotics; D025241:Spondylarthritis; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D055815:Young Adult | The Journal of rheumatology | 2,010 | D010919:Placebos |
Impacts of Limestone Multi-particle Size on Production Performance, Egg Shell Quality, and Egg Quality in Laying Hens. | This experiment was conducted to evaluate the effects of single or multi-particle size limestone on the egg shell quality, egg production, egg quality and feed intake in laying hens. A total of 280 laying hens (ISA brown) were used in this 10-wk trial. Laying hens were randomly assigned to 4 treatments with 14 replicat... | 10.5713/ajas.2011.11468 | 25,049,635 | Asian-Australasian journal of animal sciences | 2,012 | ||
A novel promoter, derived from the isocitrate lyase gene of Candida tropicalis, inducible with acetate in Saccharomyces cerevisiae. | When the isocitrate lyase gene, containing 5'-upstream and 3'-flanking regions, of an n-alkane-assimilating yeast Candida tropicalis was introduced into Saccharomyces cerevisiae, the enzyme was functionally overexpressed in the cells grown on acetate. The amount of the recombinant isocitrate lyase expressed in S. cerev... | 7,632,399 | D000085:Acetates; D019342:Acetic Acid; D002175:Candida; D007522:Isocitrate Lyase; D011401:Promoter Regions, Genetic; D011994:Recombinant Proteins; D012441:Saccharomyces cerevisiae | Applied microbiology and biotechnology | 1,995 | D000085:Acetates; D011994:Recombinant Proteins; D007522:Isocitrate Lyase; D019342:Acetic Acid | |
Atomic-scale chemical imaging of composition and bonding by aberration-corrected microscopy. | Using a fifth-order aberration-corrected scanning transmission electron microscope, which provides a factor of 100 increase in signal over an uncorrected instrument, we demonstrated two-dimensional elemental and valence-sensitive imaging at atomic resolution by means of electron energy-loss spectroscopy, with acquisiti... | 10.1126/science.1148820 | 18,292,338 | Science (New York, N.Y.) | 2,008 | ||
Detection of measles virus-specific immunoglobulin M in dried venous blood samples by using a commercial enzyme immunoassay. | The optical densities (ODs) of 216 dried venous blood (DVB) samples submitted to the Victorian Infectious Diseases Reference Laboratory as part of enhanced measles surveillance were compared to the ODs of the corresponding serum samples collected at the same time. DVB samples, stored for up to 24 months at 4 degrees C,... | 10.1128/JCM.40.1.5-9.2002 | 11,773,084 | D000293:Adolescent; D000914:Antibodies, Viral; D000918:Antibody Specificity; D001800:Blood Specimen Collection; D006801:Humans; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M; D008457:Measles; D008459:Measles virus; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D014680:Veins | Journal of clinical microbiology | 2,002 | D000914:Antibodies, Viral; D007075:Immunoglobulin M; D011933:Reagent Kits, Diagnostic |
Direct transfer of synthetic double-stranded RNA into protoplasts of Arabidopsis thaliana. | Double-stranded (ds) RNA interference (RNAi) is widely used as a reverse genetic approach for functional analysis of plant genes. Constitutive or transient RNAi effects in plants have been achieved via generating stable transformants expressing dsRNAs or artificial microRNAs (amiRNAs) in planta or by viral-induced gene... | 10.1007/978-1-61779-123-9_8 | 21,533,689 | D017360:Arabidopsis; D001483:Base Sequence; D018506:Gene Expression Regulation, Plant; D020868:Gene Silencing; D005813:Genes, Synthetic; D016133:Polymerase Chain Reaction; D011523:Protoplasts; D034622:RNA Interference; D012330:RNA, Double-Stranded; D014162:Transfection | Methods in molecular biology (Clifton, N.J.) | 2,011 | D012330:RNA, Double-Stranded |
Development of a competitive double antibody lateral flow assay for the detection of antibodies specific to glycoprotein B of Aujeszky's disease virus in swine sera. | Three lateral flow assays (LFAs) for the detection of antibodies against glycoprotein B (gB) of Aujeszky's disease virus (ADV) in swine sera: a competitive double antibody sandwich LFA without a preincubation step (CDAS-gB-LFA), a CDAS-gB-LFA with a preincubation step (pCDAS-gB-LFA), and a competitive direct gB-LFA hav... | 10.1016/j.jviromet.2016.11.011 | 27,894,861 | D000818:Animals; D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D004797:Enzyme-Linked Immunosorbent Assay; D006023:Glycoproteins; D011558:Herpesvirus 1, Suid; D009500:Neutralization Tests; D011557:Pseudorabies; D012680:Sensitivity and Specificity; D013552:Swine; D013553:Swine Diseas... | Journal of virological methods | 2,017 | D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D006023:Glycoproteins; D014759:Viral Envelope Proteins |
Homelessness and high-dosage buprenorphine misuse. | AIM
To determine whether intravenous drug users (IDUs) are more likely to misuse high dosage buprenorphine (HDB) if they are homeless.
DESIGN
We carried out a cross-sectional study using data collected from HDB users between 1998 and 1999. Data were collected by use of a structured questionnaire with questions about ... | 10.1081/ja-120017380 | 12,747,392 | D000328:Adult; D002047:Buprenorphine; D003430:Cross-Sectional Studies; D003710:Demography; D004334:Drug Administration Schedule; D005260:Female; D005602:France; D006304:Health Status; D006703:Ill-Housed Persons; D006801:Humans; D008297:Male; D009294:Narcotics; D015819:Substance Abuse, Intravenous; D011795:Surveys and Q... | Substance use & misuse | 2,003 | D009294:Narcotics; D002047:Buprenorphine |
Prevalence of vulvovaginal candidiasis in pregnancy at three health centers in Burkina Faso. | INTRODUCTION
Pregnant women are more susceptible to vaginal colonization and infection by yeast. The role of Candida colonization in the occurrence of preterm birth is well established. The knowledge of local epidemiology and identification of risk factors for preterm birth is important for the prevention and managemen... | 10.1016/j.mycmed.2017.08.006 | 28,939,305 | D000293:Adolescent; D000328:Adult; D002050:Burkina Faso; D002175:Candida; D002176:Candida albicans; D041022:Candida tropicalis; D002181:Candidiasis, Vulvovaginal; D003430:Cross-Sectional Studies; D003470:Culture Media; D005260:Female; D006801:Humans; D008430:Maternal-Child Health Centers; D008875:Middle Aged; D011247:P... | Journal de mycologie medicale | 2,018 | D003470:Culture Media |
Effect of Advanced Glycation End-Products (AGE) Lowering Drug ALT-711 on Biochemical, Vascular, and Bone Parameters in a Rat Model of CKD-MBD. | Chronic kidney disease-mineral bone disorder (CKD-MBD) is a systemic disorder that affects blood measures of bone and mineral homeostasis, vascular calcification, and bone. We hypothesized that the accumulation of advanced glycation end-products (AGEs) in CKD may be responsible for the vascular and bone pathologies via... | 10.1002/jbmr.3925 | 31,743,501 | D000818:Animals; D012080:Chronic Kidney Disease-Mineral and Bone Disorder; D008903:Minerals; D004364:Pharmaceutical Preparations; D051381:Rats; D051436:Renal Insufficiency, Chronic; D013844:Thiazoles | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research | 2,020 | D008903:Minerals; D004364:Pharmaceutical Preparations; D013844:Thiazoles; C406794:alagebrium |
Metastasis detection from whole slide images using local features and random forests. | Digital pathology has led to a demand for automated detection of regions of interest, such as cancerous tissue, from scanned whole slide images. With accurate methods using image analysis and machine learning, significant speed-up, and savings in costs through increased throughput in histological assessment could be ac... | 10.1002/cyto.a.23089 | 28,426,134 | D000328:Adult; D019540:Area Under Curve; D001943:Breast Neoplasms; D002467:Cell Nucleus; D004801:Eosine Yellowish-(YS); D005260:Female; D006416:Hematoxylin; D006651:Histocytochemistry; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008214:Lymphocytes... | Cytometry. Part A : the journal of the International Society for Analytical Cytology | 2,017 | D004801:Eosine Yellowish-(YS); D006416:Hematoxylin |
Dopamine uptake sites, labelled with [3H]GBR12935, in brain samples from depressed suicides and controls. | We have quantitated dopamine uptake sites, labelled with [3H]GBR12935, in caudate, putamen and nucleus accumbens of suicides with a retrospective diagnosis of depression, and age and gender-matched controls. Suicides were subdivided into those who had been free of antidepressant drugs for at least three months, and tho... | 10.1016/s0924-977x(97)00423-9 | 9,443,655 | D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain; D002421:Caudate Nucleus; D003866:Depressive Disorder; D004298:Dopamine; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D00971... | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology | 1,997 | D050483:Dopamine Plasma Membrane Transport Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D010879:Piperazines; D014316:Tritium; C044630:1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine; D004298:Dopamine |
Emission factors and emission inventory of diesel vehicles in Nepal. | A comprehensive emission inventory of the transport sector through fuel-based emission factors (EFs) was developed for the first time in Nepal. This study estimates air pollutants emission from diesel vehicles between the years 1989 and 2018 based on national statistical data, average vehicle kilometers travelled, fuel... | 10.1016/j.scitotenv.2021.152539 | 34,952,078 | D000393:Air Pollutants; D002244:Carbon; D004784:Environmental Monitoring; D005742:Gasoline; D018986:Motor Vehicles; D009390:Nepal; D001335:Vehicle Emissions | The Science of the total environment | 2,022 | D000393:Air Pollutants; D005742:Gasoline; D001335:Vehicle Emissions; D002244:Carbon |
Genomic prediction of carcass traits using different haplotype block partitioning methods in beef cattle. | Genomic prediction (GP) based on haplotype alleles can capture quantitative trait loci (QTL) effects and increase predictive ability because the haplotypes are expected to be in linkage disequilibrium (LD) with QTL. In this study, we constructed haploblocks using LD-based and the fixed number of single nucleotide polym... | 10.1111/eva.13491 | 36,540,636 | Evolutionary applications | 2,022 | ||
Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: distribution, temporal variability, and predictors. | BACKGROUND
Phthalate contamination exists in the North Coast karst aquifer system in Puerto Rico. In light of potential health impacts associated with phthalate exposure, targeted action for elimination of exposure sources may be warranted, especially for sensitive populations such as pregnant women. However, informati... | 24,161,445 | D000328:Adult; D015415:Biomarkers; D005260:Female; D006801:Humans; D010795:Phthalic Acids; D011247:Pregnancy; D037841:Pregnant Women; D011446:Prospective Studies; D011647:Puerto Rico; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D013997:Time Factors; D014874:Water Pollutants, Chemical; D05581... | Environment international | 2,014 | D015415:Biomarkers; D010795:Phthalic Acids; D014874:Water Pollutants, Chemical | |
Increased risk of Pneumocystis carinii and community-acquired pneumonia with tobacco use in HIV disease. | OBJECTIVES
Tobacco smoking-related diseases continue to be of great health concern for the public, in general, and may be particularly deleterious for immunosuppressed HIV-positive individuals, who exhibit widespread tobacco use.
METHODS
A total of 521 HIV-infected subjects consecutively admitted to Jackson Memorial ... | 10.1016/j.ijid.2004.07.010 | 15,916,913 | D019380:Anti-HIV Agents; D016022:Case-Control Studies; D017714:Community-Acquired Infections; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections; D006801:Humans; D008297:Male; D018410:Pneumonia, Bacterial; D011020:Pneumonia, Pneumocystis; D012307:Risk Factors; D012907:Smoking; D019966:Substance-Rel... | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases | 2,005 | D019380:Anti-HIV Agents |
Long-term NO2 exposure and mortality: A comprehensive meta-analysis. | In response to the World Health Organization's (WHO) revised annual mean nitrogen dioxide (NO2) standard from 40 μg/m3 to 10 μg/m3, reflecting the growing evidence linking long-term exposure to ambient NO2 and excess mortality, we conducted a comprehensive meta-analysis incorporating 11 new studies published since the ... | 10.1016/j.envpol.2023.122971 | 37,984,474 | Environmental pollution (Barking, Essex : 1987) | 2,023 | ||
Sedation in pediatric patients. | Sedation is being used increasingly in children to allay anxiety and discomfort. Sedation can also increase the efficiency of performing both diagnostic and therapeutic procedures in children. There are a wide array of available sedation methods that are used by radiologists, gastroenterologists, hematologists/oncologi... | 10.1007/BF02823860 | 10,829,960 | D000700:Analgesics; D002648:Child; D002675:Child, Preschool; D016292:Conscious Sedation; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D007223:Infant; D008297:Male; D010372:Pediatrics; D012680:Sensitivity and Specificity | Indian journal of pediatrics | 1,996 | D000700:Analgesics; D006993:Hypnotics and Sedatives |
Relevance of adenosine deaminase and lysozyme measurements in the diagnosis of tuberculous pericarditis. | OBJECTIVE
To assess the value of pericardial fluid adenosine deaminase (ADA) and pericardial lysozyme (Lys) as tools in diagnosing tuberculous pericarditis.
METHODS
Forty-one patients (age range 17--77 years) with significant pericardial effusion were included in the study. Diagnostic pericardiocentesis and pericardi... | 10.1159/000047296 | 11,173,777 | D000243:Adenosine Deaminase; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009113:Muramidase; D010495:Pericarditis, Tuberculous | Cardiology | 2,000 | D009113:Muramidase; D000243:Adenosine Deaminase |
Endothelial and smooth muscle cell conduction in arterioles controlling blood flow. | We performed intracellular recording with Lucifer yellow dye microinjection to investigate the cellular pathway(s) by which constriction and dilation are conducted along the wall of arterioles (diameter 47 +/- 1 microns, n = 63) supplying blood flow to the cheek pouch of anesthetized hamsters. At rest, membrane potenti... | 10.1152/ajpheart.1998.274.1.H178 | 9,458,866 | D000109:Acetylcholine; D000818:Animals; D001160:Arterioles; D001783:Blood Flow Velocity; D002610:Cheek; D006224:Cricetinae; D004730:Endothelium, Vascular; D007478:Iontophoresis; D008297:Male; D008564:Membrane Potentials; D008647:Mesocricetus; D009131:Muscle, Smooth, Vascular; D009638:Norepinephrine; D010656:Phenylephri... | The American journal of physiology | 1,998 | D010656:Phenylephrine; D011189:Potassium Chloride; D000109:Acetylcholine; D009638:Norepinephrine |
Synergistic effects of ultrasonication and ethanol washing in controlling the stoichiometry, phase-purity and morphology of rare-earth doped ceria nanoparticles. | Over a period of last thirty years, use of ethanol has been historically reported for obtaining nanopowders with low agglomeration for various oxide systems. In addition to these benefits, we show for the first time that treatments in ethanol medium coupled with an ultrasonication step can impart crucial additional adv... | 10.1016/j.ultsonch.2016.11.030 | 28,069,199 | Ultrasonics sonochemistry | 2,017 | ||
Solubility and relative absorption of copper, iron, and zinc in two milk-based liquid infant formulae. | The relative solubility of copper, iron, and zinc in two experimental liquid infant formulae are examined. The results of these trials suggest that substituting organic forms of copper and iron in the mix results in an almost three-fold increase in their solubility (iron lactate, 73.4% vs ferrous sulfate, 27.6% and cop... | 10.1080/09637480120078302 | 11,517,734 | D000704:Analysis of Variance; D000818:Animals; D003300:Copper; D006168:Guinea Pigs; D006801:Humans; D007225:Infant Food; D007231:Infant, Newborn; D007408:Intestinal Absorption; D007501:Iron; D008854:Microscopy, Electron; D008895:Milk, Human; D009753:Nutritive Value; D012995:Solubility; D015032:Zinc | International journal of food sciences and nutrition | 2,001 | D003300:Copper; D007501:Iron; D015032:Zinc |
Corticospinal excitability for hand muscles during motor imagery of foot changes with imagined force level. | The object of this study was to clarify whether corticospinal excitability controlling hand muscles changes concurrently with increases in the imagined contraction level of foot dorsiflexion. Twelve participants performed actual and imagined dorsiflexion of their right foot at three different EMG levels (10, 40 or 80% ... | 10.1371/journal.pone.0185547 | 28,957,398 | D000328:Adult; D004576:Electromyography; D019054:Evoked Potentials, Motor; D005260:Female; D005528:Foot; D006225:Hand; D006801:Humans; D019018:Imagery, Psychotherapy; D008297:Male; D009044:Motor Cortex; D013116:Spinal Cord; D055815:Young Adult | PloS one | 2,017 | |
Immunophenotyping of the PD-L1-positive cells in angioimmunoblastic T cell lymphoma and Hodgkin disease. | OBJECTIVE
Programmed death-1 (PD-1) and its ligand PD-L1 are now used as predictive biomarkers to guide clinical decisions. Precise characterization of PD-L1-positive cells may contribute to our knowledge of which patients derive benefit from the PD-L1 blockade therapy.
RESULTS
To address this issue, we performed imm... | 10.1186/s13104-020-04975-w | 32,143,684 | D000328:Adult; D018951:Antigens, CD20; D001402:B-Lymphocytes; D060890:B7-H1 Antigen; D014408:Biomarkers, Tumor; D019070:Cell Lineage; D003937:Diagnosis, Differential; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D015870:Gene Expression; D006689:Hodgkin Disease; D006801:Humans; D016130:Immunophenotypi... | BMC research notes | 2,020 | D018951:Antigens, CD20; D060890:B7-H1 Antigen; D014408:Biomarkers, Tumor; C423236:CD274 protein, human; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor |
Evusheld, a SARS-CoV-2 spike protein-directed attachment inhibitor, appears in serum protein electrophoresis and immunofixation: a case study. | Serum protein electrophoresis (SPE) and immunofixation (IFE) assays are commonly used to diagnose and monitor patients with multiple myeloma (MM). Identifying analytical interferences in SPE and IFE caused by therapeutic monoclonal antibodies (tmAbs) can be challenging. Here we report the case of a 72-year-old male wit... | 10.1093/labmed/lmad085 | 37,707,512 | D008297:Male; D006801:Humans; D000368:Aged; D064370:Spike Glycoprotein, Coronavirus; D001797:Blood Protein Electrophoresis; D000086382:COVID-19; D000086402:SARS-CoV-2; D004586:Electrophoresis; D000911:Antibodies, Monoclonal; D009101:Multiple Myeloma; D007074:Immunoglobulin G | Laboratory medicine | 2,023 | C000714168:cilgavimab and tixagevimab drug combination; C000657845:spike protein, SARS-CoV-2; D064370:Spike Glycoprotein, Coronavirus; D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G |
Quantitative optical coherence tomography of skin lesions induced by different ultraviolet B sources. | Ultraviolet B (UVB) has been widely used in dermatological phototherapy. Narrowband UVB (NB-UVB), with a peak at 311 nm, is considered to be more effective than broadband UVB (BB-UVB). However, the safety of NB-UVB is controversial. In this study, we first introduced optical coherence tomography (OCT), a novel, non-inv... | 10.1088/0031-9155/55/20/009 | 20,876,971 | D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007249:Inflammation; D051379:Mice; D008807:Mice, Inbred BALB C; D012867:Skin; D041623:Tomography, Optical Coherence; D014466:Ultraviolet Rays | Physics in medicine and biology | 2,010 | |
An investigation of the stability of free and glucuronidated 11-nor-delta9-tetrahydrocannabinol-9-carboxylic acid in authentic urine samples. | Preanalytical stability of a drug and its major metabolites is an important consideration in pharmacokinetic studies or whenever the analyte pattern is used to estimate drug habits. Firstly, the stability of free and glucuronidated 11-nor-delta9-tetrahydrocannabinol-9-carboxylic acid (THCCOOH, THCCOOglu) in authentic u... | 10.1093/jat/28.1.35 | 14,987,422 | D016477:Artifacts; D003951:Diagnostic Errors; D013759:Dronabinol; D004355:Drug Stability; D005554:Forensic Medicine; D020719:Glucuronides; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013058:Mass Spectrometry; D015813:Substance Abuse Detection; D019966:Substance-Related Disorders | Journal of analytical toxicology | 2,004 | D020719:Glucuronides; C016780:11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid; D013759:Dronabinol |
Can MRI predict olfactory loss and improvement in posttraumatic olfactory dysfunction? | BACKGROUND
Although most patients with post-traumatic olfactory dysfunction (PTOD) undergo MRI, there is no consensus about its diagnostic or prognostic value. The aims were: 1) to classify the extent of post-traumatic neurodegeneration; 2) to determine its relationship with chemosensory dysfunction (smell, taste, trig... | 10.4193/Rhin23.246 | 37,955,246 | Rhinology | 2,023 | ||
[Aging and homeostasis. Aging of skeletal muscle.] | With aging, insulin resistance and sarcopenia in skeletal muscle are induced, resulting in skeletal muscle aging. It is suggested that the former is one of the reasons that mitochondrial function decreases with aging, and the latter is due to endocrinologic dysfunction, neurological mechanism, nutritional deficiency an... | CliCa1707925932 | 28,649,097 | D000375:Aging; D006706:Homeostasis; D006801:Humans; D018482:Muscle, Skeletal; D010024:Osteoporosis; D055948:Sarcopenia | Clinical calcium | 2,017 | |
[History from neuropsychology to cognitive neurosciences in Argentina]. | The first step from the neuropsychology in Argentina was in 1883 with the thesis of Antonio Piñeiro about the brain localization of the language and vision disorders, only few years after Broca. The aim of this work has been to describe the development of the neuropsychology in Argentina and its relation with the psych... | 29,522,609 | D001118:Argentina; D000066494:Cognitive Neuroscience; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D009484:Neuropsychology | Vertex (Buenos Aires, Argentina) | 2,017 | ||
A mechanism based protein crosslinker for acyl carrier protein dehydratases. | Recent advances in the structural study of fatty acid synthase (FAS) and polyketide synthase (PKS) biosynthetic enzymes have illuminated our understanding of modular enzymes of the acetate pathway. However, one significant and persistent challenge in such analyses is resolution of the acyl carrier protein (ACP), a smal... | 10.1016/j.bmcl.2010.06.028 | 20,620,055 | D003432:Cross-Linking Reagents; D064429:Fatty Acid Synthases; D006836:Hydro-Lyases; D019906:Nuclear Magnetic Resonance, Biomolecular; D048630:Polyketide Synthases; D011485:Protein Binding; D017434:Protein Structure, Tertiary | Bioorganic & medicinal chemistry letters | 2,010 | D003432:Cross-Linking Reagents; D048630:Polyketide Synthases; D064429:Fatty Acid Synthases; D006836:Hydro-Lyases |
Risk of Bankruptcy among Applicants to Disability Insurance. | BACKGROUND
Poor health can lead to financial instability and, eventually, bankruptcy. We examined how entrance into the Social Security Disability Insurance (SSDI) program was associated with bankruptcy filings among those who had a disability and applied to the SSDI program.
METHODS
We merged dockets from U.S. bankr... | 10.1353/hpu.2015.0118 | 26,548,669 | D016361:Bankruptcy; D006233:Disabled Persons; D005260:Female; D006801:Humans; D019458:Insurance Coverage; D018868:Insurance, Disability; D008297:Male; D008875:Middle Aged; D015397:Program Evaluation; D018570:Risk Assessment; D012943:Social Security; D014481:United States | Journal of health care for the poor and underserved | 2,015 | |
Ongoing myocardial injury in stable severe heart failure: value of cardiac troponin T monitoring for high-risk patient identification. | BACKGROUND
The progression of chronic heart failure (CHF) is related to ongoing myocyte loss, which can be detected by cardiac troponin T (cTnT). We examined the prevalence and prognostic value of increased cTnT concentrations in serial blood specimens from patients with severe CHF.
METHODS AND RESULTS
Clinical, echo... | 10.1161/01.CIR.0000145158.33801.F3 | 15,477,403 | D000368:Aged; D015415:Biomarkers; D016923:Cell Death; D003327:Coronary Disease; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006333:Heart Failure; D006760:Hospitalization; D006801:Humans; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D009206:Myocardium; D032383:Myocytes, Cardia... | Circulation | 2,004 | D015415:Biomarkers; D020107:Troponin T |
[Mandibular permanent cuspids with two roots]. | When one reviews the literature, it is quite apparent that there seems to be many assumptions relative to the number of roots found in mandibular permanent canines. After having examined 806 specimens, the author of this article found that 95 per cent of mandibular canines had one root and five per cent had two roots. | 7,600,417 | D003481:Cuspid; D006801:Humans; D008334:Mandible; D014092:Tooth Root | Journal (Canadian Dental Association) | 1,995 | ||
Modulation of Steroid and Triterpenoid Metabolism in Calendula officinalis Plants and Hairy Root Cultures Exposed to Cadmium Stress. | The present study investigated the changes in the content of steroids and triterpenoids in C. officinalis hairy root cultures and plants exposed to cadmium stress. The observed effects included the content and composition of analyzed groups of compounds, particularly the proportions among individual sterols (e.g., stig... | 10.3390/ijms23105640 | 35,628,449 | D002104:Cadmium; D020838:Calendula; D010944:Plants; D013256:Steroids; D013261:Sterols; D014315:Triterpenes | International journal of molecular sciences | 2,022 | D013256:Steroids; D013261:Sterols; D014315:Triterpenes; D002104:Cadmium |
Dynamin-like proteins mediate extracellular vesicle secretion in Mycobacterium tuberculosis. | Mycobacterium tuberculosis (Mtb) secretes extracellular vesicles (EVs) containing a variety of proteins, lipoproteins, and lipoglycans. While emerging evidence suggests that EVs contribute to tuberculosis pathogenesis, the factors and molecular mechanisms involved in mycobacterial EV production have not been identified... | 10.15252/embr.202255593 | 37,079,766 | D006801:Humans; D009169:Mycobacterium tuberculosis; D014376:Tuberculosis; D000067128:Extracellular Vesicles; D007538:Isoniazid; D034281:Dynamins | EMBO reports | 2,023 | D007538:Isoniazid; D034281:Dynamins |
Drug-eluting versus bare-metal stents in saphenous vein graft lesions (ISAR-CABG): a randomised controlled superiority trial. | BACKGROUND
Comparative assessment of clinical outcomes after use of drug-eluting stents versus bare-metal stents for treatment of aortocoronary saphenous vein graft lesions has not been undertaken in large randomised trials. We aimed to undertake a comparison in a randomised trial powered for clinical endpoints.
METH... | 10.1016/S0140-6736(11)61255-5 | 21,872,918 | D020341:Absorbable Implants; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D001026:Coronary Artery Bypass; D054855:Drug-Eluting Stents; D005260:Female; D006083:Graft Occlusion, Vascular; D006801:Humans; D008297:Male; D008670:Metals; D017239:Paclitaxel; D011108:Polymers; D012501:Saphenous Vein; D020123:Sirolimus... | Lancet (London, England) | 2,011 | D008670:Metals; D011108:Polymers; D017239:Paclitaxel; D020123:Sirolimus |
Antiangiogenic effects of decorin restored by unfractionated, low molecular weight, and nonanticoagulant heparins. | Pregnancies affected by preeclampsia (PE) or fetal growth restriction (FGR) display increases in thrombin generation and reductions in angiogenesis and cell growth. There is significant interest in the potential for low molecular weight heparins (LMWHs) to reduce the recurrence of PE and FGR. However, LMWH is associate... | 10.1182/bloodadvances.2017004333 | 29,296,764 | Blood advances | 2,017 | ||
SARS-CoV-2: An immunogenetics call to arms. | Susceptibility to viral infection, development of immunity, response to treatment and patient clinical outcomes are all under the control of heritable factors in the host. In the context of the current SARS-Cov-2 pandemic, this review considers existing immunogenetic knowledge of virus-immune system interactions. A maj... | 10.1111/iji.12504 | 32,654,378 | D000073640:Betacoronavirus; D000086382:COVID-19; D018352:Coronavirus Infections; D000080424:Cytokine Release Syndrome; D004198:Disease Susceptibility; D006801:Humans; D007113:Immunity, Innate; D053583:Interleukin-1beta; D015850:Interleukin-6; D058873:Pandemics; D011024:Pneumonia, Viral; D000086402:SARS-CoV-2; D014409:T... | International journal of immunogenetics | 2,020 | C508585:IL1B protein, human; C508600:IL6 protein, human; D053583:Interleukin-1beta; D015850:Interleukin-6; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha |
Forecasting of landslide displacements using a chaos theory based wavelet analysis-Volterra filter model. | Landslide displacement time series can directly reflects landslide deformation and stability characteristics. Hence, forecasting of the non-linear and non-stationary displacement time series is necessary and significant for early warning of landslide failure. Traditionally, conventional machine learning methods are ado... | 10.1038/s41598-019-56405-y | 31,882,832 | Scientific reports | 2,019 | ||
Sources of variance in ocular microtremor. | This study presents a preliminary investigation of the sources of variance in the measurement of ocular microtremor frequency in a normal population. When the results from both experienced and relatively inexperienced operators are pooled, factors that contribute significantly to the total variance include the measurem... | 10.1088/0967-3334/15/1/009 | 8,161,957 | D000328:Adult; D000704:Analysis of Variance; D005133:Eye Movements; D005260:Female; D006801:Humans; D008297:Male; D014202:Tremor | Physiological measurement | 1,994 | |
Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca(2+)-mobilizing second messenger. Structure--activity relationship of the N1-ribose moiety. | We previously developed cyclic ADP-carbocyclic ribose (cADPcR, 2) as a stable mimic of cyclic ADP-ribose (cADPR, 1), a Ca(2+)-mobilizing second messenger. A series of the N1-ribose modified cADPcR analogues, designed as novel stable mimics of cADPR, which were the 2"-deoxy analogue 3, the 3"-deoxy analogue 4, the 3"-de... | 10.1021/ja050732x | 15,954,793 | D000818:Animals; D040761:Biomimetic Materials; D020013:Calcium Signaling; D036563:Cyclic ADP-Ribose; D006801:Humans; D008968:Molecular Conformation; D009474:Neurons; D010063:Ovum; D012617:Sea Urchins; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes | Journal of the American Chemical Society | 2,005 | C439996:cyclic ADP-carbocyclic-ribose; D036563:Cyclic ADP-Ribose |
An unusual family of glycosylated peptides isolated from Dendroaspis angusticeps venom and characterized by combination of collision induced and electron transfer dissociation. | This study describes the structural characterization of a totally new family of peptides from the venom of the snake green mamba (Dendroaspis angusticeps). Interestingly, these peptides differ in several points from other already known mamba toxins. First of all, they exhibit very small molecular masses, ranging from 1... | 10.1007/s13361-011-0210-0 | 21,952,754 | D000595:Amino Acid Sequence; D000818:Animals; D002852:Chromatography, Ion Exchange; D004546:Elapid Venoms; D017815:Elapidae; D006031:Glycosylation; D008969:Molecular Sequence Data; D010455:Peptides; D020539:Sequence Analysis, Protein; D021241:Spectrometry, Mass, Electrospray Ionization; D019032:Spectrometry, Mass, Matr... | Journal of the American Society for Mass Spectrometry | 2,011 | D004546:Elapid Venoms; D010455:Peptides |
Simultaneous inhibition of catecholamine-O-methylation by entacapone and neuronal uptake by imipramine: lack of interactions. | OBJECTIVE
We have evaluated the effects of simultaneous inhibition of catechol-O-methyltransferase (COMT) by entacapone and of neuronal monoamine reuptake by imipramine on haemodynamics and catecholamine metabolism, and the safety and tolerability of the drug combination in healthy women.
METHODS
In a randomized, sin... | 10.1007/s002280050197 | 9,010,698 | D018759:Adrenergic Uptake Inhibitors; D000328:Adult; D065098:Catechol O-Methyltransferase Inhibitors; D002396:Catechols; D018592:Cross-Over Studies; D004347:Drug Interactions; D004791:Enzyme Inhibitors; D004837:Epinephrine; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007099:Imipramine; D009570:Nitriles; D009... | European journal of clinical pharmacology | 1,996 | D018759:Adrenergic Uptake Inhibitors; D065098:Catechol O-Methyltransferase Inhibitors; D002396:Catechols; D004791:Enzyme Inhibitors; D009570:Nitriles; C071192:entacapone; D007099:Imipramine; D009638:Norepinephrine; D004837:Epinephrine |
Portal venous gas and pneumatosis intestinalis secondary to intestinal subocclusion: success of non-surgical management. | The association of intestinal and portal pneumatosis in the same patient usually occurs in intestinal ischemic-necrotic processes, with ominous prognosis. However, there are forms of presentation outside this context, with a radically different management and evolution. We present the case of a patient with portal and ... | 10.17235/reed.2020.6676/2019 | 32,579,008 | D006801:Humans; D007422:Intestines; D009336:Necrosis; D011006:Pneumatosis Cystoides Intestinalis; D011169:Portal Vein; D011379:Prognosis | Revista espanola de enfermedades digestivas | 2,020 | |
Degradation mechanism of alachlor during direct ozonation and O(3)/H(2)O(2) advanced oxidation process. | The degradation of alachlor by direct ozonation and advanced oxidation process O(3)/H(2)O(2) was investigated in this study with focus on identification of degradation byproducts. The second-order reaction rate constant between ozone and alachlor was determined to be 2.5+/-0.1M(-1)s(-1) at pH 7.0 and 20 degrees C. Twel... | 10.1016/j.chemosphere.2009.11.037 | 20,022,076 | D000081:Acetamides; D052918:Environmental Restoration and Remediation; D006540:Herbicides; D006861:Hydrogen Peroxide; D007700:Kinetics; D010084:Oxidation-Reduction; D010126:Ozone | Chemosphere | 2,010 | D000081:Acetamides; D006540:Herbicides; C000188:alachlor; D010126:Ozone; D006861:Hydrogen Peroxide |
The influence of orally deposited budesonide on the systemic availability of budesonide after inhalation from a Turbuhaler. | 1. The aim of this pharmacokinetic study was to evaluate to what extent oropharyngeal deposition of drug contributes to the systemic availability of budesonide inhaled from a dry powder inhaler (Turbuhaler). 2. The design was a randomized cross-over study in eight children aged 7-13 years. The plasma concentrations of ... | 10.1111/j.1365-2125.1993.tb04219.x | 9,114,906 | D000280:Administration, Inhalation; D000284:Administration, Oral; D000293:Adolescent; D001249:Asthma; D001682:Biological Availability; D001993:Bronchodilator Agents; D019819:Budesonide; D002648:Child; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D009960:Oropharynx; D011282:Pregnenediones | British journal of clinical pharmacology | 1,993 | D001993:Bronchodilator Agents; D011282:Pregnenediones; D019819:Budesonide |
Copro-antibody in calves from dams vaccinated against Salmonella typhimurium. | Calves received colostrum either with (positive colostrum) or without (negative colostrum) anti-Salmonella typhimurium antibodies. Regarding the detectability of copro-antibodies, the following observations have been made. In calves that had been given positive colostrum on day 4 post natum (p.n.), copro-antibodies wer... | 10.1111/j.1439-0450.1995.tb00740.x | 8,578,923 | D000818:Animals; D000831:Animals, Newborn; D000907:Antibodies, Bacterial; D002417:Cattle; D002418:Cattle Diseases; D003126:Colostrum; D005243:Feces; D005260:Female; D007112:Immunity, Maternally-Acquired; D012481:Salmonella Infections, Animal; D012486:Salmonella typhimurium; D014611:Vaccination | Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B | 1,995 | D000907:Antibodies, Bacterial |
Management of emotional distress following a myocardial infarction: a qualitative content analysis. | Myocardial infarction (MI) is one of the leading causes of mortality and disability worldwide. Emotional distress, such as anxiety and depression, are common among MI patients. The aim of this study was to investigate emotional reactions following MI and to explore how MI patients self-manage their emotional distress u... | 10.1080/16506073.2022.2135591 | 36,440,486 | D006801:Humans; D004644:Emotions; D001007:Anxiety; D009203:Myocardial Infarction; D001008:Anxiety Disorders; D000079225:Psychological Distress; D003863:Depression | Cognitive behaviour therapy | 2,023 | |
Knee osteoarthritis: primary care using noninvasive devices and biomechanical principles. | Osteoarthritis (OA) is an epidemic for which there is no known cure. There is enormous popular demand for noninvasive and nonpharmacologic therapies for OA, and there is a pressing need for primary care physicians to respond by updating their pattern of practice. Despite increasing concern about the capacity of our hea... | 10.1016/j.mcna.2008.09.007 | 19,059,028 | D001696:Biomechanical Phenomena; D001915:Braces; D002183:Canes; D006801:Humans; D020370:Osteoarthritis, Knee | The Medical clinics of North America | 2,009 | |
Comment on "Auditory-nerve first-spike latency and auditory absolute threshold: a computer model" [J. Acoust. Soc. Am. 119, 406-417 (2006)]. | A recent paper by Meddis [J. Acoust. Soc. Am. 119, 406-417 (2006)] shows that an existing model of the auditory nerve [Meddis and O'Mard, J. Acoust. Soc. Am. 117, 3787-3798 (2005)] is consistent with experimentally-measured first-spike latencies in the auditory nerve [Heil and Neubauer, J. Neurosci. 21, 7404-7415 (2001... | 10.1121/1.2213569 | 16,938,944 | D000200:Action Potentials; D001309:Auditory Threshold; D002118:Calcium; D003056:Cochlear Nerve; D003198:Computer Simulation; D006199:Hair Cells, Auditory, Inner; D006801:Humans; D008954:Models, Biological; D011930:Reaction Time | The Journal of the Acoustical Society of America | 2,006 | D002118:Calcium |
Implementation of the first worldwide quality assurance program for cystic fibrosis multiple mutation detection in population-based screening. | BACKGROUND
CDC's Newborn Screening Quality Assurance Program collaborated with several U.S. Cystic Fibrosis Care Centers to collect specimens for development of a molecular CFTR proficiency testing program using dried-blood spots for newborn screening laboratories.
METHODS
Adult and adolescent patients or carriers do... | 10.1016/j.cca.2011.04.011 | 21,514,289 | D000293:Adolescent; D000328:Adult; D019411:Clinical Laboratory Techniques; D003550:Cystic Fibrosis; D005838:Genotype; D006801:Humans; D009154:Mutation; D011785:Quality Assurance, Health Care; D012680:Sensitivity and Specificity; D055815:Young Adult | Clinica chimica acta; international journal of clinical chemistry | 2,011 | |
A clinical teaching technique for nurse preceptors: the five minute preceptor. | Although preceptorship is the leading approach to the clinical education of senior undergraduate nursing students in the westernized world, few specific nursing preceptor-focused clinical teaching techniques are reported in the literature. One promising preceptor-specific teaching strategy is the Five Step "Microskills... | 10.1016/j.profnurs.2010.09.009 | 21,272,834 | D004506:Education, Nursing; D009726:Nurses; D011231:Preceptorship | Journal of professional nursing : official journal of the American Association of Colleges of Nursing | 2,011 | |
Cerebral blood flow and its connectivity features of auditory verbal hallucinations in schizophrenia: A perfusion study. | The goal of the study was to investigate cerebral blood flow (CBF) and its connectivity (an across-subject covariance measure) patterns of schizophrenia (SZ) patients with auditory verbal hallucinations (AVHs). A total of demographically matched 25 SZ patients with AVHs, 25 without AVHs, and 25 healthy controls (HCs) u... | 10.1016/j.pscychresns.2016.12.006 | 28,024,236 | D000293:Adolescent; D000328:Adult; D001921:Brain; D001931:Brain Mapping; D002560:Cerebrovascular Circulation; D005260:Female; D006212:Hallucinations; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012559:Schizophrenia; D013060:Speech; D055815:Young Adult | Psychiatry research. Neuroimaging | 2,017 | |
Feasibility of cardiac-synchronized quantitative T1 and T2 mapping on a hybrid 1.5 Tesla magnetic resonance imaging and linear accelerator system. | Background and Purpose
The heart is important in radiotherapy either as target or organ at risk. Quantitative T1 and T2 cardiac magnetic resonance imaging (qMRI) may aid in target definition for cardiac radioablation, and imaging biomarker for cardiotoxicity assessment. Hybrid MR-linac devices could facilitate daily ca... | 10.1016/j.phro.2022.02.017 | 35,287,380 | Physics and imaging in radiation oncology | 2,022 | ||
Regulation of innate immunity signaling and its connection with human diseases. | Human innate immunity can respond to diverse microbial products, as well as other substances such as heat shock proteins, taxol, and unsaturated fatty acids. Mediated largely by a family of Toll-like-receptors (TLR) and associated intracellular downstream signaling molecules, human innate immune response serves multipl... | 10.2174/1568010043483863 | 15,032,644 | D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D008024:Ligands; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D015398:Signal Transduction; D051193:Toll-Like Receptors | Current drug targets. Inflammation and allergy | 2,004 | D008024:Ligands; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors |
Accuracy of the Hospital Anxiety and Depression Scale for identifying depression in chronic obstructive pulmonary disease patients. | Psychological morbidity is common in chronic respiratory diseases. The diagnostic accuracy of the Hospital Anxiety and Depression Scale (HADS) and risk factors for comorbid depression in chronic obstructive pulmonary disease (COPD) are addressed. Consecutive COPD patients (GOLD stage I-IV, 40-75 years old) were enrolle... | 10.1155/2014/973858 | 25,548,667 | D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003863:Depression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D029424:Pulmonary Disease, Chronic Obstructive; D015203:Reproducibility of Results; D012129:Respiratory Function Tests; D012720:S... | Pulmonary medicine | 2,014 | |
Computer-operated scanning analysis of FITC-labelled measles virus in cell cultures. | FITC-labelled measles virus antigen in infected cells was analysed by computer-operated scanning fluorometry, printed out by a mosaic printer according to a predetermined classification, and by a coordinate-recorder as a perspective image. The three-dimensional print-out of the topographic distribution of antigen accum... | 120,074 | D000818:Animals; D000937:Antigen-Antibody Reactions; D000956:Antigens, Viral; D002478:Cells, Cultured; D003201:Computers; D005455:Fluorescent Antibody Technique; D005470:Fluorometry; D000882:Haplorhini; D007668:Kidney; D008459:Measles virus; D014776:Virus Cultivation | Virologie | 1,979 | D000956:Antigens, Viral | |
Does Non-Adherence Increase Treatment Costs in Schizophrenia? | INTRODUCTION
Medication non-adherence is a serious barrier to treatment of schizophrenia. Understanding the impact of non-adherence on costs is essential to the assessment of the cost effectiveness of interventions in which adherence to treatment is a concern.
OBJECTIVES
We undertook a comprehensive review of the ava... | 10.1007/s40273-018-0652-3 | 29,700,755 | D014150:Antipsychotic Agents; D003362:Cost-Benefit Analysis; D017048:Health Care Costs; D006801:Humans; D055118:Medication Adherence; D012559:Schizophrenia | PharmacoEconomics | 2,018 | D014150:Antipsychotic Agents |
Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer. | Notch controls pancreatic differentiation during development and is reactivated in pancreatic cancer. In recent years, the importance of Notch signaling in pancreatic tumorigenesis has become increasingly evident; however, it remains unclear how Notch activities are regulated in this context. Here we report differentia... | 10.1038/onc.2015.306 | 26,279,302 | D061354:Acinar Cells; D000818:Animals; D063646:Carcinogenesis; D021441:Carcinoma, Pancreatic Ductal; D049109:Cell Proliferation; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D016695:Glycosyltransferases; D006801:Humans; D051379:Mice; D014411:Neoplastic ... | Oncogene | 2,016 | C117307:KRAS protein, human; D051880:Receptors, Notch; D025521:Tumor Suppressor Proteins; D016695:Glycosyltransferases; C498393:LFNG protein, human; D016283:Proto-Oncogene Proteins p21(ras) |
Secondary Pharmacological Prevention of Coronary Artery Disease among Patients Submitted to Clinical Management, Percutaneous Coronary Intervention, or Coronary Artery Bypass Graft Surgery. | BACKGROUND
Secondary prevention is recommended for patients with evidence of coronary artery disease (CAD) regardless of the indication for treatment by coronary artery bypass graft surgery (CABG) or percutaneous coronary intervention (PCI).
OBJECTIVES
This study evaluated whether clinical treatment, PCI or CABG had ... | 10.36660/abc.20220403 | 36,888,779 | D006801:Humans; D003324:Coronary Artery Disease; D062645:Percutaneous Coronary Intervention; D055502:Secondary Prevention; D001026:Coronary Artery Bypass; D017023:Coronary Angiography; D016896:Treatment Outcome | Arquivos brasileiros de cardiologia | 2,023 | |
Sources of stress experienced by occupational therapists and social workers in mental health settings. | This study examined the sources of stress experienced by occupational therapists and social workers employed in Australian public mental health services and identified the demographic and work-related factors related to stress using a cross-sectional survey design. Participants provided demographic and work-related inf... | 10.1002/oti.17 | 16,136,866 | D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008605:Mental Health Services; D016272:Occupational Health; D011793:Queensland; D012947:Social Work; D013315:Stress, Psychological; D016526:Workload | Occupational therapy international | 2,005 | |
Influence of planar manipulandum to the hand trajectory during point to point movement. | We present the analysis of the planar manipulandum effects to the trajectory of point to point movements in horizontal plane. This analysis is of significance for the control of a haptic robot that can be used for the rehabilitation of hemiplegic patients. The effects were assessed by comparing data collected in experi... | 10.1109/ICORR.2011.5975396 | 22,275,599 | D001132:Arm; D006801:Humans; D009068:Movement; D012371:Robotics | IEEE ... International Conference on Rehabilitation Robotics : [proceedings] | 2,011 | |
Inhibition of acetylcholinesterase activity and Fe2+-induced lipid peroxidation in rat brain in vitro by some citrus fruit juices. | This study sought to characterize the effects of some citrus fruit juices (shaddock [Citrus maxima], grapefruit [Citrus paradisii], lemon [Citrus limoni], orange [Citrus sinensis], and tangerine [Citrus reticulata]) on acetylcholinesterase activity in vitro. The total phenolic content, radical scavenging abilities, and... | 10.1089/jmf.2011.0226 | 22,400,910 | D000110:Acetylcholinesterase; D000544:Alzheimer Disease; D000818:Animals; D000975:Antioxidants; D001628:Beverages; D001713:Biphenyl Compounds; D001921:Brain; D002800:Cholinesterase Inhibitors; D002957:Citrus; D004305:Dose-Response Relationship, Drug; D005638:Fruit; D007501:Iron; D015227:Lipid Peroxidation; D008315:Malo... | Journal of medicinal food | 2,012 | D000975:Antioxidants; D001713:Biphenyl Compounds; D002800:Cholinesterase Inhibitors; D010636:Phenols; D010851:Picrates; D028321:Plant Preparations; D008315:Malondialdehyde; C004931:1,1-diphenyl-2-picrylhydrazyl; D007501:Iron; D000110:Acetylcholinesterase |
Evaluation of emphysema using three-dimensional computed tomography: association with postoperative complications in lung cancer patients. | Three-dimensional computed tomography (3D-CT) enables in vivo volumetry of total lung volume (TLV) and emphysematous low-attenuation volume (LAV) in patients with chronic obstructive pulmonary disease (COPD). We retrospectively investigated the correlation between preoperative 3D-CT volumetry and postoperative complica... | 25,797,976 | Nagoya journal of medical science | 2,015 | |||
Carcinoma of the pharynx and tonsils in an occupational cohort of asphalt workers. | BACKGROUND
We investigated a possible association between pharyngeal/tonsillar carcinoma and mixed carcinogen exposures in an asphalt roll company in Italy that used asbestos until 1979, when a new factory was built using a different production process.
METHODS
We evaluated all workers involved in the entire producti... | 10.1097/EDE.0b013e318276cc95 | 23,232,615 | D000328:Adult; D001194:Asbestos; D002273:Carcinogens; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006838:Hydrocarbons; D007558:Italy; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases; D016273:Occupational Exposure; D010610:Pharyngeal Neoplasms; D014067:Tonsillar Neoplasms | Epidemiology (Cambridge, Mass.) | 2,013 | D002273:Carcinogens; D006838:Hydrocarbons; D001194:Asbestos; C006647:asphalt |
Pro-inflammation NF-κB signaling triggers a positive feedback via enhancing cholesterol accumulation in liver cancer cells. | BACKGROUND
Hepatocellular carcinoma (HCC) develops in a complex microenvironment characterized by chronic inflammation. In recent years, cholesterol metabolic abnormalities have been implicated the importance in cancer cell physiology. This study was designed to investigate the relationship between inflammation and cho... | 10.1186/s13046-017-0490-8 | 28,100,270 | D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor; D002784:Cholesterol; D025461:Feedback, Physiological; D015972:Gene Expression Regulation, Neoplastic; D056945:Hep G2 Cells; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases; D008070:Lipopolysaccharides; D008113:Liver Neoplasms; D016328:NF-kappa B;... | Journal of experimental & clinical cancer research : CR | 2,017 | C573412:LDLR protein, human; D008070:Lipopolysaccharides; D016328:NF-kappa B; D011973:Receptors, LDL; C497390:SREBF2 protein, human; D051782:Sterol Regulatory Element Binding Protein 2; D002784:Cholesterol; C553220:HMGCR protein, human; D006903:Hydroxymethylglutaryl CoA Reductases; C472125:PCSK9 protein, human; D000071... |
Differential destabilization of the DNA oligonucleotide double helix by a T.G mismatch, 3,N(4)-ethenocytosine, 3,N(4)-ethanocytosine, or an 8-(hydroxymethyl)-3,N(4)-ethenocytosine adduct incorporated into the same sequence contexts. | The T.G mismatch and the exocyclic adduct 3,N(4)-ethenocytosine (epsilonC) are repaired by the same enzyme, the human G/T(U) mismatch-DNA glycosylase (TDG). This enzyme removes the T, U, or epsilonC base from duplex DNA. The rate of cleavage was found to differ with the lesion and was also affected by neighbor sequence... | 10.1021/tx000040g | 10,995,256 | D020137:Base Pair Mismatch; D001483:Base Sequence; D003596:Cytosine; D018736:DNA Adducts; D004268:DNA-Binding Proteins; D006147:Guanine; D008969:Molecular Sequence Data; D009841:Oligonucleotides; D013816:Thermodynamics; D013941:Thymine | Chemical research in toxicology | 2,000 | C018289:3,N(4)-ethenocytosine; C415024:8-(hydroxymethyl)-3,N(4)-ethenocytosine; D018736:DNA Adducts; D004268:DNA-Binding Proteins; D009841:Oligonucleotides; C051143:3,N(4)-ethanocytosine; D006147:Guanine; D003596:Cytosine; D013941:Thymine |
Best practice assessment of disease modelling for infectious disease outbreaks. | During emerging disease outbreaks, public health, emergency management officials and decision-makers increasingly rely on epidemiological models to forecast outbreak progression and determine the best response to health crisis needs. Outbreak response strategies derived from such modelling may include pharmaceutical di... | 10.1017/S095026881800119X | 29,734,964 | D000881:Anthrax; D002771:Cholera; D060085:Coinfection; D004196:Disease Outbreaks; D005544:Forecasting; D019142:Hemorrhagic Fever, Ebola; D006801:Humans; D007251:Influenza, Human; D008288:Malaria; D008962:Models, Theoretical; D017410:Practice Guidelines as Topic; D012899:Smallpox; D014435:Typhoid Fever | Epidemiology and infection | 2,018 | |
Genetic studies of ANKRD6 as a molecular switch between Wnt signaling pathways in human neural tube defects. | BACKGROUND
Planar cell polarity (PCP) is a major branch of Wnt signaling that controls the process of convergent extension in gastrulation and neurulation. PCP defects were associated with neural tube defects (NTDs) that are the most common central nervous system anomalies. PCP signaling is highly dosage sensitive and ... | 10.1002/bdra.23273 | 25,200,652 | D016022:Case-Control Studies; D016764:Cell Polarity; D002675:Child, Preschool; D003598:Cytoskeletal Proteins; D005260:Female; D018507:Gene Expression Regulation, Developmental; D057809:HEK293 Cells; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D009436:Neural Tube Defects; D060066:Protein Interaction Maps; ... | Birth defects research. Part A, Clinical and molecular teratology | 2,015 | C464902:ANKRD6 protein, human; D003598:Cytoskeletal Proteins |
Complete analytical and diagnostic performances of the Abbott Cell Dyn 3500. | METHODS
The study reports the analytical and diagnostic performances of Cell Dyn 3500 (Abbott), an automated haematology analyser that provides the electrical impedance and the optical detection of total leukocyte and a five population leukocyte differential count. The evaluation of complete blood count and differentia... | 9,689,832 | D001322:Autoanalysis; D001772:Blood Cell Count; D006801:Humans; D007958:Leukocyte Count; D015203:Reproducibility of Results; D012698:Serologic Tests | Panminerva medica | 1,998 | ||
Effects of presentation level on phoneme and sentence recognition in quiet by cochlear implant listeners. | OBJECTIVE
The objectives of this study were to characterize the effects of presentation level on speech recognition in quiet by cochlear implant users with the Nucleus 22 SPEAK and Clarion v1.2 CIS speech-processing strategies, and to relate speech recognition at low presentation levels to stimulus audibility as measur... | 10.1097/01.AUD.0000090340.09847.39 | 14,534,410 | D000328:Adult; D001309:Auditory Threshold; D003054:Cochlear Implants; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009622:Noise; D010700:Phonetics; D013067:Speech Perception | Ear and hearing | 2,003 | |
A point mutation in the binding subunit of a retroviral envelope protein arrests virus entry at hemifusion. | The transmembrane subunits of viral envelope proteins are thought to perform all of the functions required for membrane fusion during entry of enveloped viruses. However, changes in a conserved SPHQ motif near the N terminus of the receptor binding subunit of a murine leukemia virus (MLV) envelope protein block infecti... | 10.1128/jvi.78.1.473-481.2004 | 14,671,127 | D000818:Animals; D001120:Arginine; D002459:Cell Fusion; D002460:Cell Line; D006639:Histidine; D006801:Humans; D008561:Membrane Fusion; D051379:Mice; D008979:Moloney murine leukemia virus; D017354:Point Mutation; D011487:Protein Conformation; D014162:Transfection; D014759:Viral Envelope Proteins | Journal of virology | 2,004 | D014759:Viral Envelope Proteins; D006639:Histidine; D001120:Arginine |
Benefit of including CT urography in [68Ga]PSMA-11 PET/CT with low-dose CT: first results from a larger prostate cancer cohort analysis. | BACKGROUND
Accuracy of [68Ga]PSMA-11 PET/CT may be hampered by ureter accumulation, mimicking lymph node metastases depending on localization and configuration. The benefit of CT urography for differentiation of lymph node metastasis from urinary tract activity was evaluated in a "PET/CT with low-dose CT" setting.
ME... | 10.23736/S1824-4785.20.03224-0 | 31,992,688 | D005710:Gallium Radioisotopes; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D000072078:Positron Emission Tomography Computed Tomography; D011471:Prostatic Neoplasms; D012189:Retrospective Studies; D014567:Urography | The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... | 2,022 | D005710:Gallium Radioisotopes |
Obstacles to effective Toll-like receptor agonist therapy for hematologic malignancies. | It has long been noted that products of microorganisms have clinical activity against hematologic malignancies. Recent advances suggest that Toll-like receptors (TLRs) activated by ligands in the microbial preparations might account for some of this activity, and that defined TLR agonists might improve the clinical eff... | 10.1038/sj.onc.1210905 | 18,176,602 | D000970:Antineoplastic Agents; D001427:Bacterial Toxins; D003131:Combined Modality Therapy; D019337:Hematologic Neoplasms; D006801:Humans; D007239:Infections; D008954:Models, Biological; D015398:Signal Transduction; D051193:Toll-Like Receptors; D017211:Treatment Failure; D016896:Treatment Outcome | Oncogene | 2,008 | D000970:Antineoplastic Agents; D001427:Bacterial Toxins; D051193:Toll-Like Receptors |
Associations between condylar fractures and external auditory canal fracture: A 7-year retrospective study. | The study aimed to investigate whether the incidence rate of external auditory canal (EAC) fracture varies among different clinical types of condylar fracture. A retrospective cohort study was conducted in single hospital of China. Eligible patients diagnosed with mandibular condylar fractures were retrospectively revi... | 10.1016/j.jcms.2021.11.004 | 34,810,109 | D004424:Ear Canal; D005593:Fracture Fixation, Internal; D006801:Humans; D008335:Mandibular Condyle; D008337:Mandibular Fractures; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed | Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery | 2,022 | |
Induction of aromatase in human granulosa cells by both follicle stimulating hormone and insulin-like growth factor-I involves tyrosine phosphorylation. | Evaluation of the intracellular signalling mechanisms of follicle stimulating hormone (FSH) and insulin-like growth factor-I (IGF-I) was performed in luteinized and non-luteinized human granulosa cells. A severalfold increase in estradiol production from androstenedione was induced by both hormones in these cells, whil... | 10.3109/09513599409072453 | 7,847,103 | D000262:Adenylyl Cyclases; D000328:Adult; D001141:Aromatase; D002396:Catechols; D002478:Cells, Cultured; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation; D004790:Enzyme Induction; D004958:Estradiol; D005260:Female; D005640:Follicle St... | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology | 1,994 | D002396:Catechols; D009570:Nitriles; D020032:Tyrphostins; C060152:tyrphostin 47; D014443:Tyrosine; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D005640:Follicle Stimulating Hormone; D000242:Cyclic AMP; D001141:Aromatase; D011505:Protein-Tyrosine Kinases; D017868:Cyclic AMP-Dependent Protein Kinases; D000262... |
Pulsed xenon flash treatment inactivates bacteria in apheresis platelet concentrates while preserving in vitro quality and functionality. | BACKGROUND
Pulsed xenon (Xe) flash without any photoreactive compounds has been shown to inactivate a type of bacteria spiked into platelet (PLT) suspension in plasma, but enhanced the PLT storage lesion (PSL). Predicting reduction of PSL with increasing bactericidal ability, pulsed Xe flash was filtered through a band... | 10.1111/trf.13984 | 28,084,008 | D001419:Bacteria; D001792:Blood Platelets; D058731:Blood Safety; D004203:Disinfection; D005260:Female; D006801:Humans; D008297:Male; D050296:Microbial Viability; D010983:Plateletpheresis; D014978:Xenon | Transfusion | 2,017 | D014978:Xenon |
A 300 IR sublingual tablet is an effective, safe treatment for house dust mite-induced allergic rhinitis: An international, double-blind, placebo-controlled, randomized phase III clinical trial. | BACKGROUND
Allergic rhinitis induced by house dust mites (HDMs) is a highly prevalent but often underdiagnosed and undertreated/untreated chronic disease. It often has a negative impact on sleep, work, leisure activities, and health-related quality of life. Allergen immunotherapy is a proven, safe treatment for respira... | 10.1016/j.jaci.2020.07.036 | 32,890,575 | D000293:Adolescent; D000328:Adult; D000818:Animals; D039741:Antigens, Dermatophagoides; D004311:Double-Blind Method; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D007391:International Cooperation; D008297:Male; D015990:Placebo Effect; D039981:Pyroglyphidae; D011788:Quality of... | The Journal of allergy and clinical immunology | 2,021 | D039741:Antigens, Dermatophagoides |
Surface-enhanced Raman spectral analysis for comparison of PCR products of hepatitis B and hepatitis C. | BACKGROUND
Surface-enhanced Raman spectroscopy is a reliable tool for identification and differentiation of two diseases showing similar symptoms, hepatitis B (HBV) and hepatitis C (HCV).
OBJECTIVES
To develop a polymerase chain reaction technique (PCR) based SERS technique for differentiation of two human pathologic... | 10.1016/j.pdpdt.2021.102440 | 34,280,557 | D006509:Hepatitis B; D006526:Hepatitis C; D006801:Humans; D053768:Metal Nanoparticles; D010778:Photochemotherapy; D017319:Photosensitizing Agents; D016133:Polymerase Chain Reaction; D012834:Silver; D013059:Spectrum Analysis, Raman | Photodiagnosis and photodynamic therapy | 2,021 | D017319:Photosensitizing Agents; D012834:Silver |
Improving electrical properties of iPSC-cardiomyocytes by enhancing Cx43 expression. | The therapeutic potential of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) is limited by immature functional features including low impulse propagation and reduced cell excitability. Key players regulating electrical activity are voltage-gated Na+ channels (Nav1.5) and gap junctions built from connexi... | 10.1016/j.yjmcc.2018.05.010 | 29,777,691 | D000200:Action Potentials; D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D002478:Cells, Cultured; D018031:Connexin 43; D004558:Electric Stimulation; D005455:Fluorescent Antibody Technique; D017629:Gap Junctions; D017930:Genes, Reporter; D057026:Induced Pluripotent Stem Cells; D051379:Mice; D018613:Microscopy... | Journal of molecular and cellular cardiology | 2,018 | D018031:Connexin 43; C543076:GJA1 protein, mouse; D062554:NAV1.5 Voltage-Gated Sodium Channel |
Treatment of the aorto-iliac segment in complex lower extremity arterial occlusive disease. | Endovascular treatment of the aortoiliac segment in occlusive disease has an established role especially in TASC A and B lesions. Recent studies with modern stent technology have shown excellent results with one-year primary patency above 95%. Regarding different endovascular approaches, there is level Ib evidence supp... | 25,475,917 | D001018:Aortic Diseases; D001157:Arterial Occlusive Diseases; D003251:Constriction, Pathologic; D057510:Endovascular Procedures; D006801:Humans; D007083:Iliac Artery; D035002:Lower Extremity; D018579:Patient Selection; D011474:Prosthesis Design; D011859:Radiography; D012307:Risk Factors; D015607:Stents; D016896:Treatme... | The Journal of cardiovascular surgery | 2,015 | ||
The unusual importance of activity coefficients for micelle solutions illustrated by an osmometry study of aqueous sodium decanoate and aqueous sodium decanoate + sodium chloride solutions. | Freezing-point and vapor-pressure osmometry data are reported for aqueous sodium decanoate (NaD) solutions and aqueous NaD + NaCl solutions. The derived osmotic coefficients are analyzed with a mass-action model based on the micelle formation reaction qNa(+) + nD(-) = (Na(q)D(n))(q-n) and Guggenheim equations for the m... | 10.1039/c1cp22437a | 22,037,556 | Physical chemistry chemical physics : PCCP | 2,011 | ||
[Premedication and risks in computed tomography of newborn and infant children]. | In very young pediatric patients CT-investigations require sedative-hypnotic drug treatment to ensure complete immobilisation during scanning. The case report of a neonate with respiratory arrest after a repeated CT-premedication underlines the high risk of these procedures, especially in patients with central nervous ... | 4,089,178 | D006257:Head; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011292:Premedication; D011395:Promazine; D012306:Risk; D014057:Tomography, X-Ray Computed | Der Radiologe | 1,985 | D011395:Promazine | |
Comparative evaluation of a bioluminescent bacterial assay in terrestrial ecotoxicity testing. | Despite the widespread and successful use of luminescence-based bioassays in water testing, their applications to soils and sediments is less proven. In part this is because such bioassays have mainly been carried out in an aqueous-based medium and, as such, favour contaminants that are readily water-soluble. In this s... | 10.1039/b613734b | 17,213,941 | D048908:Aliivibrio fischeri; D001681:Biological Assay; D004926:Escherichia coli; D049449:Luminescence; D019216:Metals, Heavy; D009930:Organic Chemicals; D011551:Pseudomonas fluorescens; D015203:Reproducibility of Results; D012987:Soil; D012988:Soil Microbiology; D012989:Soil Pollutants | Journal of environmental monitoring : JEM | 2,007 | D019216:Metals, Heavy; D009930:Organic Chemicals; D012987:Soil; D012989:Soil Pollutants |
Contribution of acquired factors to the pathogenesis of dilated cardiomyopathy. -The cause of dilated cardiomyopathy: genetic or acquired? (Acquired-Side)-. | Although genetic abnormalities play a pivotal role in the development of dilated cardiomyopathy (DCM), acquired infection and autoimmune abnormalities, or both, appear to be predominant underlying disorders. Of these, viral infection causes target organ damage via perforin produced by suppressor T cells. Thereafter, va... | 10.1253/circj.cj-11-0373 | 21,617,318 | D002311:Cardiomyopathy, Dilated; D004198:Disease Susceptibility; D006801:Humans; D009154:Mutation | Circulation journal : official journal of the Japanese Circulation Society | 2,011 | |
Different affinity states of CCK(1) receptors on pancreatic acini and gastric smooth muscle in the rat. | It has recently been shown that--after chronic cholecystokinin (CCK) treatment--an adaptation of pancreatic secretory but not gastric motor function does occur. Recent studies indicate that the CCK(1)-receptor exists in two (i.e. high and low) affinity states, which could be distinguished by the CCK-analogue JMV-180. C... | 10.1016/s0928-4257(01)00053-5 | 11,595,465 | D000681:Amylases; D000818:Animals; D005753:Gastric Mucosa; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction; D009130:Muscle, Smooth; D010179:Pancreas; D051381:Rats; D017207:Rats, Sprague-Dawley; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin; D012844:Sincalide | Journal of physiology, Paris | 2,001 | D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin; C058451:JMV 180; D000681:Amylases; D012844:Sincalide |
Catalytic Asymmetric Arylation of α-Aryl-α-diazoacetates with Aniline Derivatives. | The asymmetric arylation of diazo compounds with aniline derivatives cooperatively catalyzed by an achiral dirhodium complex and a chiral spiro phosphoric acid is reported. The reaction provides a new method for the facile synthesis of α-diarylacetates, versatile building blocks with a diaryl tertiary chiral center, in... | 10.1021/jacs.5b05086 | 26,121,223 | D000085:Acetates; D000814:Aniline Compounds; D001391:Azo Compounds; D002384:Catalysis; D018360:Crystallography, X-Ray; D006841:Hydrocarbons, Aromatic; D008958:Models, Molecular; D010756:Phosphoric Acids; D012238:Rhodium; D013237:Stereoisomerism | Journal of the American Chemical Society | 2,015 | D000085:Acetates; D000814:Aniline Compounds; D001391:Azo Compounds; D006841:Hydrocarbons, Aromatic; D010756:Phosphoric Acids; D012238:Rhodium; C030242:phosphoric acid; C023650:aniline |
Expeditious synthesis of tetrasubstituted helical alkenes by a cascade of palladium-catalyzed C-H activations. | Twisted molecules: A modular approach for the synthesis of tetrasubstituted helical alkenes by a palladium-catalyzed norbornene-mediated domino reaction is presented. This intermolecular domino process allows the formation of three C-C bonds in one operation through a C-H activation/carbopalladation/C-H activation sequ... | 10.1002/anie.201204226 | 22,926,928 | D000475:Alkenes; D002384:Catalysis; D008958:Models, Molecular; D010165:Palladium; D013237:Stereoisomerism | Angewandte Chemie (International ed. in English) | 2,012 | D000475:Alkenes; D010165:Palladium |
Disseminated epidermolytic acanthoma. | A 57-year-old man developed hundreds of light brown, slightly atrophic papules, which were distributed diffusely over the back. Although clinically the lesions resembled seborrheic keratoses, histologic examination demonstrated changes of epidermolytic hyperkeratosis. The patient had neither a personal nor a family his... | 10.1097/00000372-199302000-00013 | 8,434,736 | D006801:Humans; D007642:Keratosis; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases | The American Journal of dermatopathology | 1,993 | |
[Considerations when using creatinine as a measure of kidney function]. | Reported serum creatinine concentrations can sometimes vary considerably, even when the renal function does less so or even not. This variation is partly due to true changes in actual serum concentration, and partly due to interferences in the measurement technique, thus not reflecting a true change in concentration. I... | 24,330,793 | D003401:Creatine; D003404:Creatinine; D019587:Dietary Supplements; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D051437:Renal Insufficiency | Nederlands tijdschrift voor geneeskunde | 2,013 | D003404:Creatinine; D003401:Creatine | |
Lectin histochemistry of mucus-secreting cells in the calf bulbourethral gland. | The bulbourethral glands of 2-month-old calves were studied by means of lectin histochemical methods. The lectin-binding sites for each considered lectin can be divided into three groups according to their zonal topography. In the first group including PNA, MPA, RCAI, SBA and BPA binding sites were seen in most of the ... | 1,781,254 | D000818:Animals; D002030:Bulbourethral Glands; D002417:Cattle; D006023:Glycoproteins; D007150:Immunohistochemistry; D037102:Lectins; D008297:Male; D011975:Receptors, Mitogen | Acta anatomica | 1,991 | D006023:Glycoproteins; D037102:Lectins; D011975:Receptors, Mitogen | |
Oxidation of high-density lipoprotein HDL3 leads to exposure of apo-AI and apo-AII epitopes and to formation of aldehyde protein adducts, and influences binding of oxidized low-density lipoprotein to type I and type III collagen in vitro1. | The changes in the immunological properties of apolipoprotein AI (apo-AI) and AII (apo-AII) during the oxidation of the high-density lipoprotein HDL3 and its influence on the binding of heavily oxidized low-density lipoprotein (LDL) to type I and III collagen were investigated. Oxidation of HDL3 or Eu3+-labelled HDL3 w... | 10.1042/bj3310185 | 9,512,478 | D000447:Aldehydes; D000906:Antibodies; D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001667:Binding, Competitive; D003094:Collagen; D000939:Epitopes; D006801:Humans; D015227:Lipid Peroxidation; D008075:Lipoproteins, HDL; D053440:Lipoproteins, HDL3; D008077:Lipoproteins, LDL; D008297:Male | The Biochemical journal | 1,998 | D000447:Aldehydes; D000906:Antibodies; D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D000939:Epitopes; D008075:Lipoproteins, HDL; D053440:Lipoproteins, HDL3; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D003094:Collagen |
Implicit memory for object locations depends on reactivation of encoding-related brain regions. | This study explored the correspondence between implicit memory and the reactivation of encoding-related brain regions. By using a classification method, we examined whether reactivation reflects only the similarities between study and test or voxels at the reactivated regions are diagnostic of facilitation in the impli... | 10.1002/hbm.20992 | 21,157,878 | D000293:Adolescent; D001921:Brain; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007858:Learning; D008279:Magnetic Resonance Imaging; D008297:Male; D011939:Mental Recall; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual; D011597:Psychomotor Per... | Human brain mapping | 2,011 | |
Perinatal asphyxia II: Clinical management of multisystemic sequelae. | This paper discusses the management of multisystemic sequelae of perinatal asphyxia. Appropriate intrapartum and subsequent adequate neonatal monitoring are an absolute necessity for the early detection of systemic dysfunctions. Prophylactic and therapeutic measures applicable to the various organ malfunctions are desc... | 529,305 | D001237:Asphyxia; D001238:Asphyxia Neonatorum; D001927:Brain Diseases; D002318:Cardiovascular Diseases; D005260:Female; D005315:Fetal Diseases; D006801:Humans; D007231:Infant, Newborn; D007674:Kidney Diseases; D008171:Lung Diseases; D008659:Metabolic Diseases; D008991:Monitoring, Physiologic; D011247:Pregnancy | Journal of the National Medical Association | 1,979 | ||
Cancer trends among the extreme elderly in the era of cancer screening. | BACKGROUND
The extreme elderly (EE; >84 years) are among the fastest growing segments of the population and bear a substantial cancer burden. We examined cancer incidence and cancer specific mortality changes among the EE during the implementation of cancer screening from the 1980s to 2000s.
METHODS
We examined incid... | 25,108,886 | D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms; D003110:Colonic Neoplasms; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009369:Neoplasms; D011471:Prostatic Neop... | Journal of geriatric oncology | 2,014 | ||
Non HCV-related infectious cryoglobulinemia vasculitis: Results from the French nationwide CryoVas survey and systematic review of the literature. | In patients with infectious cryoglobulinemia vasculitis (CryoVas) in the absence of hepatitis C virus infection, data on presentation, therapeutic management and outcome are lacking. We conducted a nationwide survey that included patients with HCV-negative CryoVas. We describe here the presentation, therapeutic managem... | 26,320,984 | D000305:Adrenal Cortex Hormones; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents; D001424:Bacterial Infections; D003449:Cryoglobulinemia; D003586:Cytomegalovirus Infections; D020031:Epstein-Barr Virus Infections; D005260:Female; D005602:France; D006509:Hepatitis B; D006801:Humans; D007166:Immunosuppressive A... | Journal of autoimmunity | 2,015 | D000305:Adrenal Cortex Hormones; D000890:Anti-Infective Agents; D007166:Immunosuppressive Agents; D000069283:Rituximab | |
Gene Co-expression Network Reveals Potential New Genes Related to Sugarcane Bagasse Degradation in Trichoderma reesei RUT-30. | The biomass-degrading fungus Trichoderma reesei has been considered a model for cellulose degradation, and it is the primary source of the industrial enzymatic cocktails used in second-generation (2G) ethanol production. However, although various studies and advances have been conducted to understand the cellulolytic s... | 10.3389/fbioe.2018.00151 | 30,406,095 | Frontiers in bioengineering and biotechnology | 2,018 | ||
Shape-Programmed Fabrication and Actuation of Magnetically Active Micropost Arrays. | Micro- and nanotextured surfaces with reconfigurable textures can enable advancements in the control of wetting and heat transfer, directed assembly of complex materials, and reconfigurable optics, among many applications. However, reliable and programmable directional shape in large scale is significant for prescribed... | 10.1021/acsami.0c01511 | 32,134,249 | ACS applied materials & interfaces | 2,020 | ||
Bioreducible Poly(Amino Ethers) Based mTOR siRNA Delivery for Lung Cancer. | PURPOSE
Lung cancer is one of the leading causes of deaths in the United States, but currently available therapies for lung cancer are associated with reduced efficacy and adverse side effects. Small interfering RNA (siRNA) can knock down the expression of specific genes and result in therapeutic efficacy in lung cance... | 10.1007/s11095-018-2460-z | 30,105,526 | D000970:Antineoplastic Agents; D001692:Biological Transport; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004339:Drug Compounding; D004987:Ethers; D006801:Humans; D008175:Lung Neoplasms; D010084:Oxidation-Reduction; D011108:Polymers; D034741:RNA, Small Interfering; D012235:Rhodamines | Pharmaceutical research | 2,018 | D000970:Antineoplastic Agents; D004987:Ethers; D011108:Polymers; D034741:RNA, Small Interfering; D012235:Rhodamines; C022027:lissamine rhodamine B |
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