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Glycolysis and glucose oxidation in the rat heart under nonrecirculating perfusion conditions. | Isolated rat hearts were perfused according to Langendorff and as a working heart preparation with glucose as the only exogenous substrate under nonrecirculating conditions to avoid accumulation of heart metabolites and, thereby, changes in the composition of the perfusion medium. In the absence of insulin or at low wo... | 10.1007/BF01908031 | 6,383,335 | D000255:Adenosine Triphosphate; D000818:Animals; D001786:Blood Glucose; D004734:Energy Metabolism; D005990:Glycerol; D006019:Glycolysis; D007328:Insulin; D008297:Male; D009200:Myocardial Contraction; D009206:Myocardium; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D010477:Perfusion; D010725:Phosphocreatine;... | Basic research in cardiology | 1,984 | D001786:Blood Glucose; D007328:Insulin; D011768:Pyruvate Dehydrogenase Complex; D011773:Pyruvates; D014280:Triglycerides; D010725:Phosphocreatine; D019289:Pyruvic Acid; D000255:Adenosine Triphosphate; D005990:Glycerol |
SME observations of O2 (1 delta g) nightglow: an assessment of the chemical production mechanisms. | Solar Mesosphere Explorer (SME) observations of the 3 a.m. 1.27 micrometers nightglow at 45 N latitude, averaged over the period 10-31 July 1984, are reported. From the deduced volume emission rates, we derive the O2(a1 delta g) night-time production rates for the 80-100 km altitude range. Utilizing the mean SME-acqu... | 10.1016/0032-0633(90)90145-g | 11,540,936 | D001272:Atmosphere; D003624:Darkness; D018534:Earth, Planet; D006859:Hydrogen; D008433:Mathematics; D008956:Models, Chemical; D010100:Oxygen; D010777:Photochemistry; D018531:Spacecraft; D019265:Spectroscopy, Near-Infrared | Planetary and space science | 1,990 | D006859:Hydrogen; D010100:Oxygen |
Long-term control of polycythemia rubra vera with recombinant alpha interferon. | The natural history of PRV is characterized by a prolonged period of myeloproliferation chiefly affecting the red cell series. It can be controlled by venesection and cytotoxic agents. In this case report the patient declined further 'standard' chemotherapy to control his disease and the use of relatively low doses of ... | 10.1002/(SICI)1099-1069(199603)14:1<37::AID-HON564>3.0.CO;2-F | 8,613,135 | D006801:Humans; D007370:Interferon Type I; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera; D011994:Recombinant Proteins; D013997:Time Factors | Hematological oncology | 1,996 | D007370:Interferon Type I; D011994:Recombinant Proteins |
Host-Adaptation of Burkholderia pseudomallei Alters Metabolism and Virulence: a Global Proteome Analysis. | Little is known about the evolution, adaptation and pathogenesis of Burkholderia pseudomallei within host during acute melioidosis infection. Melioidosis is a potential life threatening disease contracted through inhalation, ingestion, inoculation or direct entry of the organism into the blood stream via wounds or skin... | 10.1038/s41598-017-09373-0 | 28,827,633 | D000222:Adaptation, Physiological; D000818:Animals; D001426:Bacterial Proteins; D016957:Burkholderia pseudomallei; D004195:Disease Models, Animal; D015180:Electrophoresis, Gel, Two-Dimensional; D008554:Melioidosis; D008807:Mice, Inbred BALB C; D020543:Proteome; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Ass... | Scientific reports | 2,017 | D001426:Bacterial Proteins; D020543:Proteome; D037521:Virulence Factors |
Predicting biomolecule adsorption on MoS2 nanosheets with high structural fidelity. | A new force field, MoSu-CHARMM, for the description of bio-interfacial structures at the aqueous MoS2 interface is developed, based on quantum chemical data. The force field describes non-covalent interactions between the MoS2 surface and a wide range of chemistries including hydrocarbon, alcohol, aldehyde, ketone, car... | 10.1039/d1sc06814h | 35,655,578 | Chemical science | 2,022 | ||
Sequence analysis and transcriptional mapping of the orf-2 gene of Autographa californica nuclear polyhedrosis virus. | Sequencing of the dnapol promoter region of Autographa californica nuclear polyhedrosis virus (AcNPV) revealed an overlapping open reading frame (ORF) in an antisense orientation, referred to as ORF-2. Analysis of the ORF-2 deduced amino-acid sequence revealed two short regions of homology with a similar ORF from Lyman... | 10.1016/0378-1119(95)00715-i | 7,835,700 | D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D005814:Genes, Viral; D008969:Molecular Sequence Data; D017924:Nucleopolyhedroviruses; D016366:Open Reading Frames; D021382:Protein Sorting Signals; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic; D014764:Viral Protei... | Gene | 1,995 | C091746:Ac-bro protein, Autographa californica nucleopolyhedrovirus; D021382:Protein Sorting Signals; D014764:Viral Proteins |
Prognostic factors of recurrence after vesicovaginal fistula repair. | PURPOSE
We evaluate the prognostic factors of recurrence in patients after the surgical repair of vesicovaginal fistula.
MATERIALS AND METHODS
From 1985 to 2002, 73 women with vesicovaginal fistula underwent late (> 3 months) surgical repair. A multivariate analysis of the data was performed with the EPI-INFO softwar... | 10.1111/j.1442-2042.2006.01308.x | 16,734,848 | D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D013519:Urogenital Surgical Procedures; D014719:Vesicovaginal Fistula | International journal of urology : official journal of the Japanese Urological Association | 2,006 | |
Dissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays. | Regulation of the expression of heat-shock proteins plays an important role in the pathogenesis of Mycobacterium tuberculosis. The heat-shock response of bacteria involves genome-wide changes in gene expression. A combination of targeted mutagenesis and whole-genome expression profiling was used to characterize transcr... | 10.1099/00221287-148-10-3129 | 12,368,446 | D001426:Bacterial Proteins; D001483:Base Sequence; D004268:DNA-Binding Proteins; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D006360:Heat-Shock Proteins; D018869:Heat-Shock Response; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D009169:Mycobacterium tuberculos... | Microbiology (Reading, England) | 2,002 | D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; C108444:HspR protein, bacteria; D012097:Repressor Proteins |
Forgiveness and Gratitude: Links Between Couples' Mindfulness and Sexual and Relational Satisfaction in New Cisgender Heterosexual Marriages. | The association of mindfulness with couples' relational and sexual satisfaction may be mediated by forgiveness and gratitude. Although forgiveness and gratitude have individually been shown to play a role in couples' relational and sexual satisfaction, we use an integrated model. This study included 1,360 couples recru... | 10.1080/0092623X.2020.1842571 | 33,263,504 | D061347:Forgiveness; D020010:Heterosexuality; D006801:Humans; D008393:Marriage; D064866:Mindfulness; D010549:Personal Satisfaction | Journal of sex & marital therapy | 2,021 | |
[Isolation of Neisseria meningitidis in anorectal specimen in a men who have sex with men with uretritis and primary syphilis]. | Neisseria meningitidis is a Gram-negative bacterium frequently associated with invasive diseases with high mortality. Although its natural reservoir is the human nasopharynx, in recent years there have been increasing reports of isolation of this agent in the anorectal mucosa, mainly in men who have sex with men (MSM).... | 10.4067/s0716-10182022000200345 | 36,156,697 | D017963:Azithromycin; D002443:Ceftriaxone; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D009345:Neisseria meningitidis; D000072339:Sexual and Gender Minorities; D013587:Syphilis | Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia | 2,022 | D002443:Ceftriaxone; D017963:Azithromycin |
Lean thinking in healthcare: a realist review of the literature. | OBJECTIVE
To understand how lean thinking has been put into practice in healthcare and how it has worked.
DESIGN
A realist literature review. Data sources The authors systematically searched for articles in PubMed, Web of Science and Business Source Premier (January 1998 to February 2008) and then added articles thro... | 10.1136/qshc.2009.037986 | 20,724,397 | D003695:Delivery of Health Care; D017749:Total Quality Management | Quality & safety in health care | 2,010 | |
PulDi-COVID: Chronic obstructive pulmonary (lung) diseases with COVID-19 classification using ensemble deep convolutional neural network from chest X-ray images to minimize severity and mortality rates. | Background and Objective
In the current COVID-19 outbreak, efficient testing of COVID-19 individuals has proven vital to limiting and arresting the disease's accelerated spread globally. It has been observed that the severity and mortality ratio of COVID-19 affected patients is at greater risk because of chronic pulmon... | 10.1016/j.bspc.2022.104445 | 36,466,567 | Biomedical signal processing and control | 2,023 | ||
Serum amyloid P (SAP) is associated with impaired brachial artery flow-mediated dilation in chronically HIV-1 infected adults on stable antiretroviral therapy. | OBJECTIVE
This study aimed to evaluate the relationship between inflammatory biomarkers and endothelial dysfunction (ED), as measured by brachial artery flow-mediated dilation (FMD).
METHODS
We conducted a cross-sectional analysis utilizing baseline data of 135 participants with HIV infection on stable antiretroviral... | 10.1179/1945577115Y.0000000007 | 26,777,795 | D019380:Anti-HIV Agents; D015415:Biomarkers; D001916:Brachial Artery; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections; D015497:HIV-1; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral; D000683:Serum Amyloid P-Component; D014664:V... | HIV clinical trials | 2,015 | D019380:Anti-HIV Agents; D015415:Biomarkers; D012367:RNA, Viral; D000683:Serum Amyloid P-Component |
Deficient inhibition of return in chronic but not first-episode patients with schizophrenia. | BACKGROUND
Inhibition of return (IOR) has been tested in patients with schizophrenia with contradictory results. Some studies indicated that patients with schizophrenia have normal levels of IOR; however, other studies reported delayed or blunted IOR. Inconsistency in findings might be due to differences across studies... | 10.1016/j.pnpbp.2010.05.002 | 20,460,142 | D000328:Adult; D000704:Analysis of Variance; D001288:Attention; D003071:Cognition; D003463:Cues; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D009483:Neuropsychological Tests; D011930:Reaction Time; D012559:Schizophrenia | Progress in neuro-psychopharmacology & biological psychiatry | 2,010 | |
[Fatal interstitial lung disease and pneumocystis during dermatomyositis associated with anti-MDA5 antibodies]. | BACKGROUND
Dermatomyositis (DM) in an auto-immune inflammatory myopathy with skin lesions, and, occasionally, organ involvement. Herein, we report a case of DM during anti-MDA5 antibody therapy associated with interstitial lung disease (ILD) and pneumocystosis.
PATIENTS AND METHODS
A 64-year-old woman was hospitalize... | 10.1016/j.annder.2020.08.046 | 33,131,899 | D001323:Autoantibodies; D003882:Dermatomyositis; D005260:Female; D006801:Humans; D000072640:Interferon-Induced Helicase, IFIH1; D017563:Lung Diseases, Interstitial; D008875:Middle Aged; D011010:Pneumocystis; D011020:Pneumonia, Pneumocystis | Annales de dermatologie et de venereologie | 2,020 | D001323:Autoantibodies; D000072640:Interferon-Induced Helicase, IFIH1 |
Vaccination of chickens against Newcastle disease with a food pellet vaccine. | The Australian, heat-resistant, a virulent V4 strain of Newcastle disease (ND) virus was selected for further heat resistance to give a variant designated V4-UPM. V4-UPM was sprayed on to food pellets which were fed to chickens in amounts calculated to give about 10(6) EID50 per chicken. Chickens vaccinated only once b... | 10.1080/03079459008418687 | 18,679,945 | Avian pathology : journal of the W.V.P.A | 1,990 | ||
Long-term cancer pain management in morphine pre-treated and opioid naive patients with transdermal fentanyl. | There is emerging data supporting the use of TTS-F (transdermal therapeutic system-fentanyl) in opioid naive patients. Our study examines the safety and efficacy of TTS-F in the long-term control of cancer pain in opioid naive patients and those transferring from oral morphine. Pain was assessed in 589 patients (Group ... | 10.1002/ijc.11416 | 14,506,751 | D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005283:Fentanyl; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine; D009369:Neoplasms; D010148:Pain, Intractable; D011446:Prospective Studies; D011788:Quality of Life | International journal of cancer | 2,003 | D009020:Morphine; D005283:Fentanyl |
Agreeing with automated diagnostic aids: a study of users' concurrence strategies. | Automated diagnostic aids that are less than perfectly reliable often produce unwarranted levels of disuse by operators. In the present study, users' tendencies to either agree or disagree with automated diagnostic aids were examined under conditions in which (a) the aids were less than perfectly reliable but aided-dia... | 10.1518/0018720024494847 | 12,118,872 | D000328:Adult; D000704:Analysis of Variance; D003657:Decision Making; D006801:Humans; D015203:Reproducibility of Results; D012309:Risk-Taking; D013647:Task Performance and Analysis | Human factors | 2,002 | |
Functional neuroanatomical evidence for the double-deficit hypothesis of developmental dyslexia. | The double-deficit hypothesis of dyslexia posits that both rapid naming and phonological impairments can cause reading difficulties, and that individuals who have both of these deficits show greater reading impairments compared to those with a single deficit. Despite extensive behavioral research, the brain basis of po... | 24,953,957 | D001921:Brain; D002648:Child; D004410:Dyslexia; D005260:Female; D006801:Humans; D007600:Judgment; D007807:Language Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D008960:Models, Psychological; D009434:Neural Pathways; D009483:Neuropsychological Tests; D010700:Phonetics; D011932:Reading; D012815:Signal Process... | Neuropsychologia | 2,014 | ||
Relation between infection with Helicobacter pylori and living conditions in childhood: evidence for person to person transmission in early life. | OBJECTIVES
To relate the prevalence of infection with Helicobacter pylori in adults to their living conditions in childhood to identify risk factors for infection.
DESIGN
Prevalence study of IgG antibodies to H pylori (> 10 micrograms IgG/ml, determined by enzyme linked immunosorbent assay (ELISA)) and reported livin... | 10.1136/bmj.308.6931.750 | 8,142,828 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial; D003441:Crowding; D004739:England; D004797:Enzyme-Linked Immunosorbent Assay; D005192:Family Health; D016481:Helicobacter Infections; D016480:Helicobacter pylori; D006798:Housing; D006801:Humans; D007074:Immunoglobulin G; D008297:Male; D008... | BMJ (Clinical research ed.) | 1,994 | D000907:Antibodies, Bacterial; D007074:Immunoglobulin G |
Marital status and satisfaction five years following a randomized clinical trial comparing traditional versus integrative behavioral couple therapy. | OBJECTIVE
To follow distressed married couples for 5 years after their participation in a randomized clinical trial.
METHOD
A total of 134 chronically and seriously distressed married couples were randomly assigned to approximately 8 months of either traditional behavioral couple therapy (TBCT; Jacobson & Margolin, 1... | 10.1037/a0018132 | 20,350,033 | D000328:Adult; D001521:Behavior Therapy; D019546:Couples Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D055048:Integrative Medicine; D008297:Male; D017533:Marital Status; D010549:Personal Satisfaction; D013997:Time Factors | Journal of consulting and clinical psychology | 2,010 | |
Application of starter cultures to table olive fermentation: an overview on the experimental studies. | Table olives are one of the oldest fermented foods and are considered as an important component of the Mediterranean diet, since their richness in monounsaturated fats (primarily oleic acid) and phenolic compounds may function as antioxidants in the human body; in the Western world they represent one of the most popula... | 10.3389/fmicb.2012.00248 | 22,833,739 | Frontiers in microbiology | 2,012 | ||
Esophageal dysfunction in different stages of Parkinson's disease. | BACKGROUND
Dysphagia is a clinically relevant symptom in patients with Parkinson's disease (PD) leading to pronounced reduction in quality of life and other severe complications. Parkinson's disease-related dysphagia may affect the oral and pharyngeal, as well as the esophageal phase of swallowing.
METHODS
To examine... | 10.1111/nmo.12915 | 27,477,636 | D000368:Aged; D003679:Deglutition; D003680:Deglutition Disorders; D018450:Disease Progression; D016099:Endoscopy, Gastrointestinal; D015154:Esophageal Motility Disorders; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010300:Parkinson Disease; D011788:Quality of Life; D012189:Ret... | Neurogastroenterology and motility | 2,017 | |
Characterization of prostaglandin F2 alpha receptor of mouse 3T3 fibroblasts and its functional expression in Xenopus laevis oocytes. | Prostaglandin (PG) F2 alpha increased [3H]thymidine incorporation into quiescent NIH 3T3 cells, stimulated phosphoinositide breakdown, and raised intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner with ED50 values of 2.0 x 10(-8) M, 4.6 x 10(-8) M, and 7.5 x 10(-8) M, respectively. The increase in [3... | 10.1002/jcp.1041550206 | 8,482,718 | D016475:3T3 Cells; D000818:Animals; D002118:Calcium; D002462:Cell Membrane; D004247:DNA; D015237:Dinoprost; D005260:Female; D007267:Injections; D007295:Inositol Phosphates; D051379:Mice; D009865:Oocytes; D009994:Osmolar Concentration; D012333:RNA, Messenger; D011982:Receptors, Prostaglandin; D014982:Xenopus laevis | Journal of cellular physiology | 1,993 | D007295:Inositol Phosphates; D012333:RNA, Messenger; D011982:Receptors, Prostaglandin; C034671:prostaglandin F2alpha receptor; D004247:DNA; D015237:Dinoprost; D002118:Calcium |
Highly Stretchable, Weavable, and Washable Piezoresistive Microfiber Sensors. | A key challenge in electronic textiles is to develop an intrinsically conductive thread of sufficient robustness and sensitivity. Here, we demonstrate an elastomeric functionalized microfiber sensor suitable for smart textile and wearable electronics. Unlike conventional conductive threads, our microfiber is highly fle... | 10.1021/acsami.7b19823 | 29,582,649 | ACS applied materials & interfaces | 2,018 | ||
Pepsin in saliva for the diagnosis of gastro-oesophageal reflux disease. | OBJECTIVE
Current diagnostic methods for gastro-oesophageal reflux disease (GORD) have moderate sensitivity/specificity and can be invasive and expensive. Pepsin detection in saliva has been proposed as an 'office-based' method for GORD diagnosis. The aims of this study were to establish normal values of salivary pepsi... | 10.1136/gutjnl-2014-307049 | 24,812,000 | D000328:Adult; D016022:Case-Control Studies; D004435:Eating; D005260:Female; D005764:Gastroesophageal Reflux; D006356:Heartburn; D006801:Humans; D008297:Male; D008875:Middle Aged; D010434:Pepsin A; D012016:Reference Values; D012463:Saliva; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D055815... | Gut | 2,015 | D010434:Pepsin A |
WinGene/WinPep: user-friendly software for the analysis of amino acid sequences. | WinGene1.0/WinPep1.2 is a pair of Microsoft Windows programs designed to read nucleotide or amino acid sequence data. These versatile programs have the following capabilities: (i) searches for open reading frames and their translation, (ii) assisting the design of primers for PCR and (iii) calculation of molecular weig... | 10.2144/99266bc02 | 10,376,156 | D000595:Amino Acid Sequence; D004247:DNA; D017931:DNA Primers; D007526:Isoelectric Point; D008970:Molecular Weight; D016366:Open Reading Frames; D017421:Sequence Analysis; D012984:Software; D014584:User-Computer Interface | BioTechniques | 1,999 | D017931:DNA Primers; D004247:DNA |
[Expression of p53, p21 and bcl-2 in prognosis of lung carcinomas]. | Expression of suppressor genes 53 and bcl-2 as well as of protein p21 (partly induced by p53 gene) was analyzed in a group of 77 resection specimens and bronchial excision of lung carcinomas (of all basic histological types--squamous cell, neuroendocrine, adenocarcinoma, undifferentiated). Simultaneously the relation o... | 10,677,910 | D014408:Biomarkers, Tumor; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2; D016283:Proto-Oncogene Proteins p21(ras); D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 | Ceskoslovenska patologie | 1,999 | D014408:Biomarkers, Tumor; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras) | |
Interactive national virtual water-energy nexus networks. | Across the globe, many regions import virtual resources to support their development. Although many researchers have studied transfers of a single virtual resource, interactions across two types of virtual resource transfer networks - energy and water, for example - have rarely been explored simultaneously. To address ... | 10.1016/j.scitotenv.2019.03.298 | 30,981,920 | The Science of the total environment | 2,019 | ||
A bifunctionalized fluorogenic tetrasaccharide as a substrate to study cellulases. | Cellulases are usually classified as endoglucanases and cellobiohydrolases, but the heterogeneity of cellulose, in terms of particle size and crystallinity, has always represented a problem for the biochemical characterization of the enzymes. The synthesis of a bifunctionalized tetrasaccharide substrate suitable for me... | 10.1074/jbc.272.5.2709 | 9,006,908 | D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002480:Cellulase; D004735:Energy Transfer; D007202:Indicators and Reagents; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D003904:Mitosporic Fungi; D008969:Molecular Sequence Data; D009282:Naphthalenesulfonates; D009844:Oligosaccharides; D0... | The Journal of biological chemistry | 1,997 | D007202:Indicators and Reagents; D009282:Naphthalenesulfonates; D009844:Oligosaccharides; C104421:indolethyl 6-N-6-(5-(2-aminoethylamino)-1-naphthalenesulfonate)-6-deoxygalactopyranosyl-1-4-glucopyranosyl-1-4-glucopyranosyl-1-4-glycopyranoside; D002480:Cellulase |
In COPD, prophylactic macrolides, but not tetracyclines or quinolones, reduce exacerbations, with fewer serious adverse events. | Janjua S, Mathioudakis AG, Fortescue R, et al. Prophylactic antibiotics for adults with chronic obstructive pulmonary disease: a network meta-analysis. Cochrane Database Syst Rev. 2021;1:CD013198. 33448349. | 10.7326/ACPJ202106150-066 | 34,058,115 | D000328:Adult; D000900:Anti-Bacterial Agents; D019072:Antibiotic Prophylaxis; D018450:Disease Progression; D006801:Humans; D018942:Macrolides; D029424:Pulmonary Disease, Chronic Obstructive; D015363:Quinolones; D013754:Tetracyclines | Annals of internal medicine | 2,021 | D000900:Anti-Bacterial Agents; D018942:Macrolides; D015363:Quinolones; D013754:Tetracyclines |
Transcriptional activation of human mu-opioid receptor gene by insulin-like growth factor-I in neuronal cells is modulated by the transcription factor REST. | The human mu-opioid receptor gene (OPRM1) promoter contains a DNA sequence binding the repressor element 1 silencing transcription factor (REST) that is implicated in transcriptional repression. We investigated whether insulin-like growth factor I (IGF-I), which affects various aspects of neuronal induction and maturat... | 10.1111/j.1471-4159.2008.05303.x | 18,284,609 | D000818:Animals; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins; D006801:Humans; D007334:Insulin-Like Growth Factor I; D009447:Neuroblastoma; D009474:Neurons; D016716:PC12 Cells; D011485:Protein Binding; D051381:Rats; D017450:Receptors, Opioid, mu; D012097:Repressor Proteins; D0155... | Journal of neurochemistry | 2,008 | D004268:DNA-Binding Proteins; C092779:RE1-silencing transcription factor; D017450:Receptors, Opioid, mu; D012097:Repressor Proteins; D014212:Tretinoin; D007334:Insulin-Like Growth Factor I |
Caspase-1-mediated cytokine release from gestational tissues, placental, and cord blood. | Distinguishing between fetal and maternal inflammatory responses is necessary for understanding the immune interplay either side of the placenta. Fetal immunity reaches maturity during extrauterine life and while basic inflammatory responses afford a certain degree of protection, fetuses are vulnerable to infection. Wi... | 10.3389/fphys.2015.00186 | 26,157,394 | Frontiers in physiology | 2,015 | ||
Expanding prostheses in conservative surgery for lower limb sarcoma. | Conservative resection of bone sarcoma in the lower limbs in children is very likely to be followed by a progressive problem of leg length inequality resulting from removal of the growth cartilage. To overcome this we have been using an expanding prosthesis and we report our experiences during the period 1985-1996. The... | 10.1007/s002640050202 | 9,549,578 | D000293:Adolescent; D001859:Bone Neoplasms; D002648:Child; D002675:Child, Preschool; D005260:Female; D005266:Femoral Neoplasms; D006801:Humans; D008297:Male; D012516:Osteosarcoma; D019736:Prostheses and Implants; D011474:Prosthesis Design; D012512:Sarcoma, Ewing; D013584:Sarcoma, Synovial; D013977:Tibia | International orthopaedics | 1,998 | |
Monovalent ion selectivity sequences of the rat connexin43 gap junction channel. | The relative permeability sequences of the rat connexin 43 (rCx43) gap junction channel to seven cations and chloride were examined by double whole cell patch clamp recording of single gap junction channel currents in rCx43 transfected neuroblastoma 2A (N2A) cell pairs. The measured maximal single channel slope conduct... | 10.1085/jgp.109.4.491 | 9,101,407 | D000818:Animals; D002412:Cations; D018031:Connexin 43; D004058:Diffusion; D004558:Electric Stimulation; D004594:Electrophysiology; D017629:Gap Junctions; D007473:Ion Channels; D008564:Membrane Potentials; D051379:Mice; D008954:Models, Biological; D009994:Osmolar Concentration; D018408:Patch-Clamp Techniques; D010539:Pe... | The Journal of general physiology | 1,997 | D002412:Cations; D018031:Connexin 43; D007473:Ion Channels |
Impact of omission of axillary lymph node dissection after negative sentinel lymph node biopsy: 70-month follow-up. | BACKGROUND
The objective of this study is to assess the oncologic safety of sentinel lymph node biopsy (SLNB), especially with regard to the axillary recurrence (AR) rate, and to determine the risk factors for AR and disease-free survival (DFS) and overall survival (OS) after negative SLNB.
MATERIALS AND METHODS
Betw... | 10.1245/s10434-010-0951-1 | 20,162,458 | D000704:Analysis of Variance; D001365:Axilla; D001943:Breast Neoplasms; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012307:Risk Factors; ... | Annals of surgical oncology | 2,010 | |
Induction of caspase-3-dependent apoptosis in human leukemia HL-60 cells by δ-elemene. | δ-Elemene, an antitumor component, is a chemical compound isolated from Curcuma wenyujin, a Chinese traditional herb. We examined whether δ-elemene could inhibit cell growth and cell cycle progression and induce apoptosis in human leukemia HL-60 cells. The results demonstrated that δ-elemene induces significant apoptos... | 10.1248/yakushi.131.1383 | 21,881,314 | D000590:Amino Acid Chloromethyl Ketones; D017209:Apoptosis; D053148:Caspase 3; D002455:Cell Division; D045744:Cell Line, Tumor; D030024:Curcuma; D045304:Cytochromes c; D003600:Cytosol; D004305:Dose-Response Relationship, Drug; D016195:G2 Phase; D018922:HL-60 Cells; D006801:Humans; D053078:Membrane Potential, Mitochondr... | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan | 2,011 | D000590:Amino Acid Chloromethyl Ketones; D012717:Sesquiterpenes; D051028:bcl-2-Associated X Protein; C096713:benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone; C038905:elemene; D045304:Cytochromes c; D053148:Caspase 3 |
Late pulmonary complications of treating Hodgkin lymphoma: bleomycin-induced toxicity. | INTRODUCTION
Survival of Hodgkin lymphoma (HL) patients has significantly improved in recent decades. The current first-line therapy is doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) ± irradiation and may cause pulmonary toxicity. Strategies to reduce late toxicity as well as increase survival rate are of inte... | 10.1517/14740338.2014.946901 | 25,135,756 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; D004305:Dose-Response Relationship, Drug; D005260:Female; D006689:Hodgkin Disease; D006801:Humans; D008171:Lung Diseases; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D012189:Retrospective ... | Expert opinion on drug safety | 2,014 | D000903:Antibiotics, Antineoplastic; D001761:Bleomycin |
Mitochondrial substrate availability and its role in lipid-induced insulin resistance and proinflammatory signaling in skeletal muscle. | The relationship between glucose and lipid metabolism has been of significant interest in understanding the pathogenesis of obesity-induced insulin resistance. To gain insight into this metabolic paradigm, we explored the potential interplay between cellular glucose flux and lipid-induced metabolic dysfunction within s... | 10.2337/db13-0264 | 23,733,201 | D000818:Animals; D000963:Antimetabolites; D003847:Deoxyglucose; D005230:Fatty Acids, Nonesterified; D006019:Glycolysis; D015151:Immunoblotting; D007249:Inflammation; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008297:Male; D008928:Mitochondria; D018482:Muscle, Skeletal; D009765:Obesity; D010084:Oxidation-Red... | Diabetes | 2,013 | D000963:Antimetabolites; D005230:Fatty Acids, Nonesterified; D010168:Palmitates; D003847:Deoxyglucose |
Chemical modification of the coat protein in bacteriophage fd and orientation of the virion during assembly and disassembly. | The major (gene VIII) coat protein of bacteriophage fd was radiolabelled by treating the virus with methyl[3H]acetimidate without causing any loss of infectivity. Complete amidination of lysine-8 in the amino acid sequence of the protein was achieved but little or no modification of the lysine residues near the C termi... | 10.1002/j.1460-2075.1983.tb01638.x | 6,357,778 | D000596:Amino Acids; D002213:Capsid; D003090:Coliphages; D004926:Escherichia coli; D007096:Imidoesters; D007202:Indicators and Reagents; D010446:Peptide Fragments; D014771:Virion | The EMBO journal | 1,983 | D000596:Amino Acids; D007096:Imidoesters; D007202:Indicators and Reagents; D010446:Peptide Fragments; C010222:methyl acetimidate |
Pegylated and liposomal doxorubicin is associated with high mortality and causes limited cardiotoxicity in mice. | OBJECTIVE
We wanted to determine the impact of different doses of a pegylated and liposomal formulation of the cardiotoxic drug doxorubicin on cardiac function, fibrosis and survival in mice. The drug causes myocardial damage by producing reactive oxygen species, mitochondrial damage and lipid peroxidation. Thymosin be... | 10.1186/s13104-018-3260-6 | 29,467,032 | D000818:Animals; D009202:Cardiomyopathies; D066126:Cardiotoxicity; D004195:Disease Models, Animal; D004317:Doxorubicin; D004562:Electrocardiography; D008297:Male; D051379:Mice; D011092:Polyethylene Glycols; D013947:Thymosin | BMC research notes | 2,018 | C506643:liposomal doxorubicin; D011092:Polyethylene Glycols; C033402:thymosin beta(4); D013947:Thymosin; D004317:Doxorubicin |
Evaluation of radioactive 125I seed implantation for the treatment of refractory malignant tumours based on a CT-guided 3D template-assisted technique: efficacy and safety. | BACKGROUND
To observe the medium- and long-term clinical efficacy and safety of radioactive 125I seed implantation for refractory malignant tumours based on CT-guided 3D template-assisted technique.
METHODS
Twenty-five patients with refractory malignant tumours who underwent radioactive 125I seed implantation based o... | 10.1186/s12885-020-07223-3 | 32,746,784 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D018450:Disease Progression; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D017567:Karnofsky Performance Status; D008297:Male; D008875:Middle Aged; D009369:Neoplasms; D011879:Radiotherapy Dosage; D012074:Remission Induction; ... | BMC cancer | 2,020 | D007457:Iodine Radioisotopes; C000614960:Iodine-125 |
[Study on the relationship between single-nucleotide polymorphisms in IL-6, IL-10 genes and HBV-related hepatocellular carcinoma]. | OBJECTIVE
To investigate the association between single nucleotide polymorphisms (SNPs) in cytokine IL-6, IL-10 genes and HBV-related hepatocellular carcinoma (HCC).
METHODS
A hospital-based case-control study was conducted in 381 cases with HBV-related HCC, 340 HBsAg carriers and 359 non-tumor controls. Genotypes of... | 21,569,738 | D000483:Alleles; D006528:Carcinoma, Hepatocellular; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006515:Hepatitis B virus; D006801:Humans; D016753:Interleukin-10; D015850:Interleukin-6; D008113:Liver Neoplasms; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide | Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | 2,011 | C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016753:Interleukin-10 | |
Physical Activity of Malaysian Primary School Children: Comparison by Sociodemographic Variables and Activity Domains. | This study describes the physical activity of primary school children according to sociodemographic characteristics and activity domains. Using the Malaysian South East Asian Nutrition Surveys data, 1702 children aged 7 to 12 years were included in the analysis. Physical activity was reported as a total score and categ... | 10.1177/1010539516650726 | 27,257,293 | D000367:Age Factors; D001835:Body Weight; D002648:Child; D003430:Cross-Sectional Studies; D005006:Ethnicity; D015444:Exercise; D005260:Female; D006801:Humans; D007182:Income; D008296:Malaysia; D008297:Male; D012111:Residence Characteristics; D012574:Schools; D012737:Sex Factors; D013334:Students | Asia-Pacific journal of public health | 2,016 | |
Care of the stroke patient: routine management to lifesaving treatment options. | The management of the acute ischemic stroke patient spans the time course from the emergency evaluation and treatment period through to the eventual discharge planning phase of stroke care. In this article we evaluate the literature and describe what have become standard treatments in the care of the stroke patient. We... | 10.1007/s13311-011-0061-1 | 21,748,527 | D001929:Brain Edema; D019468:Disease Management; D006801:Humans; D006943:Hyperglycemia; D020521:Stroke; D014057:Tomography, X-Ray Computed; D054556:Venous Thromboembolism | Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics | 2,011 | |
Evaluation of Millipore Cartridge-type Water Treatment Systems for Microbiological Applications. | Two different cartridge-type water treatment systems were evaluated for use in the microbiology laboratory, employing the Distilled Water Suitability Test (DWST). The Milli-Q system fed by distilled water and the Milli-R/Q system fed by tap water both produced water acceptable for microbiological use as measured by the... | 10.4315/0362-028X-42.8.654 | 30,812,313 | Journal of food protection | 1,979 | ||
Variation in reaction norms: Statistical considerations and biological interpretation. | Analysis of reaction norms, the functions by which the phenotype produced by a given genotype depends on the environment, is critical to studying many aspects of phenotypic evolution. Different techniques are available for quantifying different aspects of reaction norm variation. We examine what biological inferences c... | 10.1111/evo.13003 | 27,431,762 | D005075:Biological Evolution; D004777:Environment; D005838:Genotype; D008957:Models, Genetic; D015233:Models, Statistical; D010641:Phenotype; D012641:Selection, Genetic | Evolution; international journal of organic evolution | 2,016 | |
Towards the Synthesis of a Heterocyclic Analogue of Natural Cyclooligopeptide with Improved Bio-properties. | AIMS
The present investigation is targeted towards the synthesis of a novel analogue of a natural peptide of marine origin.
BACKGROUND
Marine sponges are enriched with bioactive secondary metabolites, especially circu-lar peptides. Heterocycles are established organic compounds with potential biological value. Tak-in... | 10.2174/1570179418666211005141811 | 34,636,301 | D000818:Animals; D000935:Antifungal Agents; D004952:Esters; D008826:Microbial Sensitivity Tests; D009835:Oligochaeta; D010455:Peptides; D010456:Peptides, Cyclic; D011161:Porifera; D011392:Proline; D014633:Valine | Current organic synthesis | 2,022 | D000935:Antifungal Agents; D004952:Esters; D010455:Peptides; D010456:Peptides, Cyclic; D011392:Proline; D014633:Valine |
Dynamic assessment of multilingual children's word learning. | BACKGROUND
Teachers and clinicians may struggle to provide early identification to support multilingual children's language development. Dynamic assessments are a promising approach to identify and support children's language development.
AIMS
We developed and studied a novel word learning task that is dynamic and la... | 10.1111/1460-6984.12723 | 35,429,340 | D002648:Child; D002663:Child Language; D006801:Humans; D007807:Language Tests; D019303:Multilingualism; D014706:Verbal Learning; D014825:Vocabulary | International journal of language & communication disorders | 2,022 | |
Short-Term Interaction with Endothelial Cells Enhances Angiogenic Activity of Growth-Arrested Mesenchymal Stromal Cells In Vitro and In Ovo. | We compared angiogenic effects of conditioned medium from mesenchymal stromal cell (MSC) monoculture and co-culture of MSC with endothelial cells (EC). Conditioned medium from 24-h EC-MSC co-cultures significantly stimulated the proliferation and migration of EC in monoculture and growth of the vascular network of the ... | 10.1007/s10517-022-05660-7 | 36,437,339 | D042783:Endothelial Cells; D059630:Mesenchymal Stem Cells | Bulletin of experimental biology and medicine | 2,022 | |
The ubiquity of the tabletability flip phenomenon. | The plasticity of materials plays a critical role in adequate powder tabletability, which is required in developing a successful tablet product. Generally, a more plastic material can develop larger bonding areas when other factors are the same, leading to higher tabletability than less plastic materials. However, it w... | 10.1016/j.ijpharm.2023.123262 | 37,495,026 | D004339:Drug Compounding; D013607:Tablets; D011208:Powders; D013718:Tensile Strength | International journal of pharmaceutics | 2,023 | D013607:Tablets; D011208:Powders |
Simple box model for dense-gas dispersion in a straight sloping channel. | A box model for instantaneous release and subsequent one-dimensional spreading of isothermal dense gases on sloping surfaces is presented. A numerical solution and an approximate analytical solution of the model equations are compared to the experimental data obtained in a sloping heavy-gas channel of the Institute of ... | 10.1016/s0304-3894(00)00209-0 | 10,828,385 | D002617:Chemical Industry; D005740:Gases; D008962:Models, Theoretical; D018570:Risk Assessment | Journal of hazardous materials | 2,000 | D005740:Gases |
Zebrafish neurobehavioral phenomics applied as the behavioral warning methods for fingerprinting endocrine disrupting effect by lead exposure at environmentally relevant level. | Environmental lead (Pb) exposure is a great hazard to the public health. Although environmentally relevant Pb poisoning is preventable, insidious Pb contaminants are still a major threat to human health. Herein, we reported that exposure to Pb at environmentally relevant concentration level (1 μg/L, 10 μg/L and 100 μg/... | 10.1016/j.chemosphere.2019.05.146 | 31,132,538 | D000818:Animals; D001522:Behavior, Animal; D053148:Caspase 3; D052244:Endocrine Disruptors; D004703:Endocrine System; D004787:Environmental Pollution; D006801:Humans; D007854:Lead; D008297:Male; D015203:Reproducibility of Results; D013737:Testis; D014874:Water Pollutants, Chemical; D015027:Zebrafish | Chemosphere | 2,019 | D052244:Endocrine Disruptors; D014874:Water Pollutants, Chemical; D007854:Lead; C505407:CASP3 protein, human; D053148:Caspase 3 |
Assembly of Guanine Crystals as a Low-Polarizing Broadband Multilayer Reflector in a Spider, Phoroncidia rubroargentea. | The diminishing of the polarization effect is important in the applications of dielectric multilayer reflectors in many optical systems, such as low-loss broadband waveguides, optical fibers, and LEDs. Low-polarizing broadband reflections were identified from birefringent-guanine-crystal-based multilayer reflectors in ... | 10.1021/acsami.2c09546 | 35,834,638 | ACS applied materials & interfaces | 2,022 | ||
A single platelet aggregometric assay for pro-and antiaggregatory prostanoids. | A method is described for characterizing disaggregatory and proaggregatory prostanoids in a single assay. This "post-addition assay" consists of adding the test agent to PRP containing PGI2 (4-6 nM) 90 sec after an ADP challenge. The relative potencies of known inhibitors of ADP-induced aggregation were identical to th... | 10.1016/0262-1746(82)90098-1 | 6,757,967 | D000244:Adenosine Diphosphate; D001792:Blood Platelets; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol; D005227:Fatty Acids; D006801:Humans; D008722:Methods; D010974:Platelet Aggregation; D011458:Prostaglandins E; D011466:Prostanoic Acids | Prostaglandins, leukotrienes, and medicine | 1,982 | D005227:Fatty Acids; D011458:Prostaglandins E; D011466:Prostanoic Acids; D000244:Adenosine Diphosphate; D011464:Epoprostenol |
Phase shift in dielectric reflection. | The phase shifts in external dielectric reflection were analyzed as a function of the incident angle. The contrast of the interference fringes formed between the incident and the reflected beams was considered. For the parallel mode the phase shift disappears between 45 degrees and the Brewster angle. Experimental resu... | 10.1364/AO.26.003871 | 20,490,156 | Applied optics | 1,987 | ||
Optical Absorption on Electron Quantum-Confined States of Perovskite Quantum Dots. | In the framework of the dipole approximation, it is shown that in the perovskites quantum dots (QDs) FAPbBr3 and {en} FAPbBr3 interacting with low-intensity light, the oscillator strengths of transitions, as well as the dipole moments allowing transitions between one-particle electron quantum-confined states, attain ... | 10.3390/nano12172973 | 36,080,011 | Nanomaterials (Basel, Switzerland) | 2,022 | ||
Targeting the blood-brain barrier to delay aging-accompanied neurological diseases by modulating gut microbiota, circadian rhythms, and their interplays. | The blood-brain barrier (BBB) impairment plays a crucial role in the pathological processes of aging-accompanied neurological diseases (AAND). Meanwhile, circadian rhythms disruption and gut microbiota dysbiosis are associated with increased morbidity of neurological diseases in the accelerated aging population. Import... | 10.1016/j.apsb.2023.08.009 | 38,045,038 | Acta pharmaceutica Sinica. B | 2,023 | ||
An embolic deflection device for aortic valve interventions. | OBJECTIVES
We describe initial human experience with a novel cerebral embolic protection device.
BACKGROUND
Cerebral emboli are the major cause of procedural stroke during percutaneous aortic valve interventions.
METHODS
With right radial artery access, the embolic protection device is advanced into the aortic arch... | 10.1016/j.jcin.2010.05.022 | 21,087,748 | D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis; D001794:Blood Pressure; D001955:British Columbia; D006328:Cardiac Catheterization; D002404:Catheterization; D057505:Embolic Protection Devices; D005240:Feasibility Studies; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D020766:Intr... | JACC. Cardiovascular interventions | 2,010 | |
Coherent functional modules improve transcription factor target identification, cooperativity prediction, and disease association. | Transcription factors (TFs) are fundamental controllers of cellular regulation that function in a complex and combinatorial manner. Accurate identification of a transcription factor's targets is essential to understanding the role that factors play in disease biology. However, due to a high false positive rate, identif... | 10.1371/journal.pgen.1004122 | 24,516,403 | D002453:Cell Cycle; D019295:Computational Biology; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D058977:Molecular Sequence Annotation; D060066:Protein Interaction Maps; D014157:Transcription Factors | PLoS genetics | 2,014 | D014157:Transcription Factors |
Outcomes for patients with synchronous and metachronous primary lung cancer after diagnosis of head and neck cancer. | BACKGROUND
Not-infrequently patients with head and neck cancer are also diagnosed with synchronous lung cancer or metachronous primary lung cancer, which complicates the treatment decisions and prognosis.
METHODS
Patients were identified from a database of patients with head and neck cancer with second primary non-sm... | 10.1002/hed.24751 | 28,593,651 | D000230:Adenocarcinoma; D000368:Aged; D000369:Aged, 80 and over; D018287:Carcinoma, Large Cell; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms; D006801:Humans; D008175:Lung Neoplasms; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D016609:Neoplasms, Second Pr... | Head & neck | 2,017 | |
PLOD3 Is Associated with Immune Cell Infiltration and Genomic Instability in Colon Adenocarcinoma. | Procollagen-lysine, 2-oxoglutarate 5-dioxygenases (PLODs) are a family of enzymes. However, the clinical and functional roles of PLOD3 in colon adenocarcinoma (COAD) have not been investigated. The present study found that PLOD3 was highly upregulated in COAD, which may be resulted from its aberrant DNA methylation. Th... | 10.1155/2021/4714526 | 34,239,923 | D000230:Adenocarcinoma; D003110:Colonic Neoplasms; D016208:Databases, Factual; D058750:Epithelial-Mesenchymal Transition; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D042822:Genomic Instability; D005943:Gluconeogenesis; D006801:Humans; D007107:Immune System; D008240:Procollagen-Ly... | BioMed research international | 2,021 | D016212:Transforming Growth Factor beta; C475767:PLOD3 protein, human; D008240:Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase |
Epidemiological and nutrition transition in developing countries: impact on human health and development. | Whereas common infectious and parasitic diseases such as malaria and the HIV/AIDS pandemic remain major unresolved health problems in many developing countries, emerging non-communicable diseases relating to diet and lifestyle have been increasing over the last two decades, thus creating a double burden of disease and ... | 10.1017/S0029665108006058 | 18,234,135 | D002908:Chronic Disease; D003141:Communicable Diseases; D015897:Comorbidity; D003906:Developing Countries; D004032:Diet; D006304:Health Status; D006801:Humans; D008019:Life Style; D009748:Nutrition Disorders; D009747:Nutritional Physiological Phenomena; D009765:Obesity; D012923:Social Class | The Proceedings of the Nutrition Society | 2,008 | |
Evaluation of serum and salivary total sialic acid and α-l-fucosidase in patients with oral precancerous conditions and oral cancer. | OBJECTIVES
We compared serum and salivary total sialic acid/total protein (TSA/TP) ratios and α-l-fucosidase activity in patients with oral precancerous conditions (OPCs) and oral cancer to better understand the utility of saliva, in monitoring early changes occurring during oral cancer progression.
STUDY DESIGN
A cr... | 23,570,662 | D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D018450:Disease Progression; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Ne... | Oral surgery, oral medicine, oral pathology and oral radiology | 2,013 | D014408:Biomarkers, Tumor; D005644:alpha-L-Fucosidase; D019158:N-Acetylneuraminic Acid | |
Design of leaving groups in radical C-C fragmentations: through-bond 2c-3e interactions in self-terminating radical cascades. | Radical cascades terminated by β-scission of exocyclic CC bonds allow for the formation of aromatic products. Whereas β-scission is common for weaker bonds, achieving this reactivity for carbon-carbon bonds requires careful design of radical leaving groups. It has now been found that the energetic penalty for breaking... | 10.1002/chem.201402843 | 24,898,770 | Chemistry (Weinheim an der Bergstrasse, Germany) | 2,014 | ||
Assessment of hepatocellular carcinomas using conventional magnetic resonance imaging correlated with histological differentiation and a serum marker of poor prognosis. | PURPOSE
To establish a method of assessing the malignant potential of hepatocellular carcinoma (HCC) using magnetic resonance imaging (MRI).
METHODS
For 69 nodules [12 Edmondson (Ed)-I, 48 Ed-II, 9 Ed-III] in 54 HCC patients, signal intensity patterns and enhancement patterns of gadopentate dimeglumine (Gd-DTPA) dyna... | 10.1007/s12072-010-9245-8 | 21,484,138 | Hepatology international | 2,011 | ||
Intensity statistics in the presence of translational noncrystallographic symmetry. | In the case of translational noncrystallographic symmetry (tNCS), two or more copies of a component in the asymmetric unit of the crystal are present in a similar orientation. This causes systematic modulations of the reflection intensities in the diffraction pattern, leading to problems with structure determination an... | 10.1107/S0907444912045374 | 23,385,454 | D001483:Base Sequence; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D030562:Databases, Protein; D005583:Fourier Analysis; D016013:Likelihood Functions; D008958:Models, Molecular; D014176:Protein Biosynthesis; D011897:Random Allocation; D014961:X-Ray Diffraction | Acta crystallographica. Section D, Biological crystallography | 2,013 | |
Moderate irrigation intervals facilitate establishment of two desert shrubs in the Taklimakan Desert Highway Shelterbelt in China. | BACKGROUND
Water influences various physiological and ecological processes of plants in different ecosystems, especially in desert ecosystems. The purpose of this study is to investigate the response of physiological and morphological acclimation of two shrubs Haloxylon ammodendron and Calligonum mongolicunl to variati... | 10.1371/journal.pone.0180875 | 28,719,623 | D000064:Acclimatization; D057914:Agricultural Irrigation; D027703:Amaranthaceae; D018533:Biomass; D029748:Caryophyllaceae; D002681:China; D003889:Desert Climate; D010788:Photosynthesis; D018515:Plant Leaves; D012987:Soil; D013997:Time Factors; D014867:Water | PloS one | 2,017 | D012987:Soil; D014867:Water |
Frailty among institutionalized older people: a cross-sectional study in Natal (Brazil). | OBJECTIVE
Verify the prevalence of frailty and its associated factors in institutionalized older people.
METHODS
Cross-sectional study carried out in 10 nursing homes in Natal (Brazil), between October/2013 and January/2014. All institutionalized older people 60+ that were not hospitalized, in terminal state, coma or... | 10.22540/JFSF-04-051 | 32,300,718 | Journal of frailty, sarcopenia and falls | 2,019 | ||
Plant Antioxidants for Food Safety and Quality: Exploring New Trends of Research. | Antioxidants are an heterogeneous group of compounds able to counteract cell oxidation by acting as reducing agents, as free radical scavengers, and quenchers of radical species and other pro-oxidants, such as metals [...]. | 10.3390/antiox10060972 | 34,204,398 | Antioxidants (Basel, Switzerland) | 2,021 | ||
Kinetic validation of 6-NBDG as a probe for the glucose transporter GLUT1 in astrocytes. | In recent years, the use of fluorescent glucose analogs has allowed the study of rapid transport modulation in heterogeneous cell cultures and complex tissues. However, the kinetic behavior of these tracers is not conventional. For instance, the fluorescent glucose analog 6-NBDG permeates the cell 50-100 times slower t... | 10.1111/j.1471-4159.2009.05885.x | 19,393,014 | D009327:4-Chloro-7-nitrobenzofurazan; D000818:Animals; D001253:Astrocytes; D002478:Cells, Cultured; D003571:Cytochalasin B; D004058:Diffusion; D005944:Glucosamine; D005947:Glucose; D051272:Glucose Transporter Type 1; D007700:Kinetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D01... | Journal of neurochemistry | 2,009 | D051272:Glucose Transporter Type 1; C045400:6-deoxy-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminoglucose; D003571:Cytochalasin B; D009327:4-Chloro-7-nitrobenzofurazan; D005947:Glucose; D005944:Glucosamine |
A New Biased Discriminant Analysis Using Composite Vectors for Eye Detection. | We propose a new biased discriminant analysis (BDA) using composite vectors for eye detection. A composite vector consists of several pixels inside a window on an image. The covariance of composite vectors is obtained from their inner product and can be considered as a generalization of the covariance of pixels. The pr... | 10.1109/TSMCB.2012.2186798 | 22,410,345 | IEEE transactions on systems, man, and cybernetics. Part B, Cybernetics : a publication of the IEEE Systems, Man, and Cybernetics Society | 2,012 | ||
Species diversification patterns in the Polynesian jumping spider genus Havaika Prószyński, 2001 (Araneae, Salticidae). | Hotspot archipelagoes provide exceptional models for the study of the evolutionary process, due to the effects of isolation and topographical diversity in inducing the formation of unique biotic assemblages. In this paper, we examine the evolutionary patterns exhibited by the jumping spider genus Havaika Prószyński, 20... | 10.1016/j.ympev.2006.05.012 | 16,837,219 | D000818:Animals; D001483:Base Sequence; D001499:Bayes Theorem; D005075:Biological Evolution; D049628:Body Size; D049810:Genetic Speciation; D010641:Phenotype; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S; D012356:RNA, Transfer, Leu; D016415:Sequence Alignment; D013112:Spiders | Molecular phylogenetics and evolution | 2,006 | D012336:RNA, Ribosomal, 16S; D012356:RNA, Transfer, Leu |
[Are the hereditary forms of BRCA1 and BRCA2 breast cancer sensitive to estrogens?]. | There is emerging evidence from clinical and experimental data that familial breast cancers, including BRCA1 and BRCA2 related forms, could be in fact estrogen-sensitive. Interactions between BRCA1 gene expression and estrogens have been reported. On one hand, BRCA1 expression could be induced by estradiol in experimen... | 15,381,448 | D018931:Antineoplastic Agents, Hormonal; D001943:Breast Neoplasms; D049109:Cell Proliferation; D003278:Contraceptives, Oral, Hormonal; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004967:Estrogens; D005260:Female; D005786:Gene Expression Regulation; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D0200... | Bulletin du cancer | 2,004 | D018931:Antineoplastic Agents, Hormonal; D003278:Contraceptives, Oral, Hormonal; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004967:Estrogens; D013629:Tamoxifen | |
Interleukin 16 expression changes in association with ovarian malignant transformation. | OBJECTIVE
Long-term unresolved inflammation has been suggested as a risk factor for the development of various malignancies. The goal of this study was to examine whether the expression of interleukin (IL)-16, a proinflammatory cytokine, changes in association with ovarian cancer (OVCA) development.
STUDY DESIGN
In a... | 24,380,743 | D000328:Adult; D000818:Animals; D002471:Cell Transformation, Neoplastic; D002645:Chickens; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019410:Interleukin-16; D008875:Middle Aged; D010051:Ovarian Neoplasms; D010053:Ovary | American journal of obstetrics and gynecology | 2,014 | D019410:Interleukin-16 | |
Effectiveness of ICT-based intimate partner violence interventions: a systematic review. | BACKGROUND
Intimate Partner Violence is a "global pandemic". Meanwhile, information and communication technologies (ICT), such as the internet, mobile phones, and smartphones, are spreading worldwide, including in low- and middle-income countries. We reviewed the available evidence on the use of ICT-based interventions... | 10.1186/s12889-020-09408-8 | 32,894,115 | D030881:Disclosure; D005260:Female; D006801:Humans; D000073256:Information Technology; D000066511:Intimate Partner Violence; D008297:Male; D008403:Mass Screening; D008603:Mental Health; D012984:Software; D017216:Telemedicine; D016387:Women's Health | BMC public health | 2,020 | |
Antioxidant enzymes in the human iris: an immunogold study. | AIMS
To determine the nature and extent of the antioxidant enzyme system in the human iris.
METHODS
The fine structural distribution of five antioxidant enzymes (acidic, neutral, and basic glutathione S-transferase (GST), Cu/Zn superoxide dismutase (Cu/Zn SOD), and glutathione peroxidase) was determined by immunogold... | 10.1136/bjo.81.4.314 | 9,215,062 | D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes; D005260:Female; D005979:Glutathione Peroxidase; D005982:Glutathione Transferase; D006801:Humans; D007150:Immunohistochemistry; D007498:Iris; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D013482:Superoxide Dis... | The British journal of ophthalmology | 1,997 | D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase |
Toxicity of insecticides for control of freshwater Culex annulirostris (Diptera: Culicidae) to the nontarget shrimp, Caradina indistincta (Decapoda: Atyidae). | Laboratory evaluations were conducted in southeastern Queensland, Australia, to determine the toxicities of two organophosphate compounds (temephos and pirimiphos-methyl), an insect growth regulator (s-methoprene), and an entomopathogenic bacterium (Bacillus thuringiensis variety israelensis de Barjac [B.t.i.]) to Cule... | 10.1603/0022-0493-93.3.667 | 10,902,314 | D000818:Animals; D001681:Biological Assay; D003465:Culex; D033364:Decapoda; D005618:Fresh Water; D007306:Insecticides; D009032:Mosquito Control; D009946:Organothiophosphorus Compounds; D000002:Temefos | Journal of economic entomology | 2,000 | D007306:Insecticides; D009946:Organothiophosphorus Compounds; C014153:pirimiphos methyl; D000002:Temefos |
Algebraic framework of an optimization problem in diagnosis. | A formal analysis of an optimization problem in medical diagnosis is presented. The mathematical model of the diagnostic process corresponds in this work to an abstract machine definition which is based on the following sets and functions: Set of possible pathological states (diseases) of a patient, set of diagnostic t... | 10.1016/0020-7101(79)90009-6 | 385,508 | D003933:Diagnosis; D003936:Diagnosis, Computer-Assisted; D006801:Humans; D008433:Mathematics; D008954:Models, Biological | International journal of bio-medical computing | 1,979 | |
In vivo electrophysiological characterization of 5-HT receptors in the guinea pig head of caudate nucleus and orbitofrontal cortex. | The aim of the present study was to characterize in vivo the 5-HT receptor subtypes which mediate the effect of microiontophoretic applied 5-HT in the guinea pig head of caudate nucleus and orbitofrontal cortex. 5-HT and the preferential 5-HT2A receptor agonist DOI and the preferential 5-HT2C receptor agonist mCPP, sup... | 10.1016/s0028-3908(97)00035-x | 9,225,283 | D000818:Animals; D002421:Caudate Nucleus; D004594:Electrophysiology; D006168:Guinea Pigs; D007275:Injections, Intravenous; D007478:Iontophoresis; D008297:Male; D009474:Neurons; D017397:Prefrontal Cortex; D017661:Receptors, Presynaptic; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Recep... | Neuropharmacology | 1,997 | D017661:Receptors, Presynaptic; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists |
Idiopathic central serous retinopathy in China: a report of 600 cases (624 eyes) treated by acupuncture. | Six hundred Chinese patients (624 eyes) with clinically diagnosed central serous retinopathy were treated by consecutive courses of acupuncture. Eighty-six percent of patients had resolution of their subretinal fluid within 3 months of treatment, a result similar to the natural history of the disease as reported by oth... | 3,658,317 | D015670:Acupuncture Therapy; D002681:China; D006801:Humans; D012008:Recurrence; D012164:Retinal Diseases; D012189:Retrospective Studies | Ophthalmic surgery | 1,987 | ||
Throbbing headache is not always migraine; it can be serious. | Cerebral venous thrombosis (CVT) is a rare but serious venous thrombotic disorder in the general population. It has an estimated annual incidence of about 4-5 cases per 1 million persons. It is more common in females than males. We describe below a case of a 49-year-old female patient who presented to the emergency roo... | 10.3402/jchimp.v6.32361 | 27,802,851 | Journal of community hospital internal medicine perspectives | 2,016 | ||
Changing Body Image and Well-Being: Following the Experience of Massive Weight Loss and Body Contouring Surgery. | This paper reports on the perception of changing body image and well-being for patients who had undergone plastic surgery following massive weight loss. The exploratory, qualitative study was undertaken with 20 patients from one teaching hospital in the south of England. Semi-structured interviews were carried out and ... | 10.3390/healthcare2020150 | 27,429,267 | Healthcare (Basel, Switzerland) | 2,014 | ||
Lung recruitment before surfactant administration in extremely preterm neonates with respiratory distress syndrome (IN-REC-SUR-E): a randomised, unblinded, controlled trial. | BACKGROUND
The importance of lung recruitment before surfactant administration has been shown in animal studies. Well designed trials in preterm infants are absent. We aimed to examine whether the application of a recruitment manoeuvre just before surfactant administration, followed by rapid extubation (intubate-recrui... | 10.1016/S2213-2600(20)30179-X | 32,687,801 | D060666:Airway Extubation; D003422:Critical Care; D005260:Female; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D007442:Intubation, Intratracheal; D007558:Italy; D008168:Lung; D008297:Male; D011663:Pulmonary Surfactants; D012121:Respiration, Artifi... | The Lancet. Respiratory medicine | 2,021 | D011663:Pulmonary Surfactants |
Distinct Characteristics of Odor-evoked Calcium and Electrophysiological Signals in Mitral/Tufted Cells in the Mouse Olfactory Bulb. | Fiber photometry is a recently-developed method that indirectly measures neural activity by monitoring Ca2+ signals in genetically-identified neuronal populations. Although fiber photometry is widely used in neuroscience research, the relationship between the recorded Ca2+ signals and direct electrophysiological measur... | 10.1007/s12264-021-00680-1 | 33,856,645 | D000818:Animals; D002118:Calcium; D055724:Electrophysiological Phenomena; D051379:Mice; D009474:Neurons; D009812:Odorants; D009830:Olfactory Bulb | Neuroscience bulletin | 2,021 | D002118:Calcium |
Isolation of phages infecting Actinoplanes SN223 and characterization of two of these viruses. | Phages infecting the industrially important Actinoplanes strain SN223 were isolated from soil samples collected at the shores of inland waters in Germany. The genome sizes range from 53 kb to 58 kb. Preliminary analyses revealed G+C contents comparable with the G/C bias of the host. Electron microscopy of three selecte... | 10.1007/s00253-003-1473-6 | 14,586,581 | D001433:Bacteriolysis; D001435:Bacteriophages; D001482:Base Composition; D004279:DNA, Viral; D004587:Electrophoresis, Agar Gel; D016679:Genome, Viral; D005858:Germany; D008242:Lysogeny; D008848:Micromonosporaceae; D008854:Microscopy, Electron; D019251:Nucleocapsid; D012988:Soil Microbiology | Applied microbiology and biotechnology | 2,004 | D004279:DNA, Viral |
Stabilization of a helical water chain in a metal-organic host of a trinuclear Schiff base complex. | Three heterometallic trinuclear Schiff base complexes, [{CuL1(H2O)}2Ni(CN)4].4H2O (1), [{CuL2(H2O)}2Ni(CN)4] (2), and [{CuL3(H2O)}2Ni(CN)4] (3) (HL1=7-amino-4-methyl-5-azahept-3-en-2-one, HL2=7-methylamino-4-methyl-5-azahept-3-en-2-one, and HL3=7-dimethylamino-4-methyl-5-azahept-3-en-2-one), were synthesized. All three... | 10.1021/ic8002542 | 18,459,727 | Inorganic chemistry | 2,008 | ||
Ethanol-induced skeletal muscle myopathy: biochemical and histochemical measurements on type I and type II fibre-rich muscles in the young rat. | Rats were pair-fed either a nutritionally complete liquid diet containing 36% of total calories as ethanol or isovolumetric amounts of the same diet in which ethanol was substituted by isocaloric glucose. Chronic ethanol feeding caused a preferential decline in the wet weight of the plantaris (predominantly Type II mus... | 10.1093/oxfordjournals.alcalc.a044956 | 2,627,241 | D000428:Alcohol Drinking; D000437:Alcoholism; D000818:Animals; D004247:DNA; D008297:Male; D009124:Muscle Proteins; D009132:Muscles; D009133:Muscular Atrophy; D051381:Rats; D011919:Rats, Inbred Strains | Alcohol and alcoholism (Oxford, Oxfordshire) | 1,989 | D009124:Muscle Proteins; D004247:DNA |
High-performance capillary electrophoretic separation of double-stranded oligonucleotides using a poly-(ethylpyrrolidine methacrylate-co-methylmethacrylate)-coated capillary. | Here we describe a capillary electrophoretic method for the separation of double-stranded oligonucleotides (ds-ODNs) ranging from 16-20 bp with 2 bp resolution using a low concentration of poly(ethylpyrrolidine methacrylate-co-methyl methacrylate) (PEPyM-co-PMMA) copolymer physically adsorbed to a capillary surface. Co... | 10.1002/elps.201100514 | 22,539,324 | D019075:Electrophoresis, Capillary; D009841:Oligonucleotides; D011109:Polymethacrylic Acids; D011758:Pyrroles; D015203:Reproducibility of Results; D013696:Temperature | Electrophoresis | 2,012 | D009841:Oligonucleotides; D011109:Polymethacrylic Acids; D011758:Pyrroles |
VMAT-like plans for magnetic resonance guided radiotherapy: Addressing unmet needs. | PURPOSE
VMAT delivery technique is currently not applicable to Magnetic Resonance-guided radiotherapy (MRgRT) hybrid systems. Aim of this study is to evaluate an innovative VMAT-like (VML) delivery technique.
MATERIAL AND METHODS
First, planning and dosimetric evaluation of the MRgRT VML treatment have been performed... | 10.1016/j.ejmp.2021.05.002 | 33,979,726 | D009682:Magnetic Resonance Spectroscopy; D058958:Organs at Risk; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies | Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) | 2,021 | |
Incidence of Atrial Fibrillation in Elite Athletes. | Importance
Vigorous exercise (particularly endurance sports) might increase the risk of atrial fibrillation (AF), but there is variability in the reported frequency of this condition among elite athletes. The underlying pathophysiologic source remains unclear.
Objective
To determine AF incidence in a large cohort of ... | 10.1001/jamacardio.2018.3482 | 30,383,155 | D000328:Adult; D056352:Athletes; D001281:Atrial Fibrillation; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006325:Heart Atria; D006801:Humans; D015994:Incidence; D008297:Male; D010807:Physical Endurance; D012189:Retrospective Studies; D013030:Spain | JAMA cardiology | 2,018 | |
Global importance analysis: An interpretability method to quantify importance of genomic features in deep neural networks. | Deep neural networks have demonstrated improved performance at predicting the sequence specificities of DNA- and RNA-binding proteins compared to previous methods that rely on k-mers and position weight matrices. To gain insights into why a DNN makes a given prediction, model interpretability methods, such as attributi... | 10.1371/journal.pcbi.1008925 | 33,983,921 | D019295:Computational Biology; D000077321:Deep Learning; D023281:Genomics; D006801:Humans; D016571:Neural Networks, Computer | PLoS computational biology | 2,021 | |
Leoligin-inspired synthetic lignans with selectivity for cell-type and bioactivity relevant for cardiovascular disease. | Recently, a natural compound leoligin, a furan-type lignan, was discovered as an interesting hit compound with an anti-inflammatory pharmacological activity profile. We developed a modular and stereoselective approach for the synthesis of the edelweiss-derived lignan leoligin and used the synthetic route to rapidly pre... | 10.1039/c9sc00446g | 31,293,770 | Chemical science | 2,019 | ||
Selective Eradication of Staphylococcus aureus by the Designer Genetically Programmed Yeast Biocontrol Agent. | Staphylococcus aureus is a common human pathogen that is particularly often associated with antibiotic resistance. The eradication of this ubiquitous infectious agent from its ecological niches and contaminated surfaces is especially complicated by excessive biofilm formation and persisting cells, which evade the antib... | 10.3390/antibiotics9090527 | 32,824,911 | Antibiotics (Basel, Switzerland) | 2,020 | ||
Adult primary retroperitoneal cavernous hemangioma: a case report. | Primary retroperitoneal cavernous hemangioma (PRCH) in an adult is extremely rare. We report on the diagnosis and treatment of a patient with PRCH with subtle clinical features and atypical findings on imaging scans. A 38-year-old man was admitted to hospital with a 5-day history of epigastralgia after alcohol drinking... | 10.1186/1477-7819-10-261 | 23,216,883 | D000328:Adult; D006392:Hemangioma, Cavernous; D006801:Humans; D008297:Male; D012186:Retroperitoneal Neoplasms | World journal of surgical oncology | 2,012 | |
The physiologic significance of portal vs. peripheral injection of insulin in man. | The site and rate of entry of insulin into the body may affect its metabolic actions. This study tested for the first time in man the hypothesis that the mode of action of endogenous insulin differs from peripherally injected insulin. In 11 nondiabetic and six diabetic patients we compared the effects on peripheral glu... | 10.1097/00000441-197501000-00004 | 1,130,434 | D001786:Blood Glucose; D003920:Diabetes Mellitus; D005947:Glucose; D006801:Humans; D007003:Hypoglycemia; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007328:Insulin; D008102:Liver Circulation; D008297:Male; D011677:Punctures; D013154:Spleen; D013997:Time Factors; D014044:Tolbutamide | The American journal of the medical sciences | 1,975 | D001786:Blood Glucose; D007328:Insulin; D014044:Tolbutamide; D005947:Glucose |
Being in a crowd bonds people via physiological synchrony. | Collective events can generate intense emotions, shape group identities, and forge strong bonds. Do these effects extend to remote participation, and what are the psychological mechanisms underpinning their social power? We monitored psycho-physiological activity among groups of basketball fans who either attended game... | 10.1038/s41598-021-04548-2 | 35,022,461 | D001341:Autonomic Nervous System; D003441:Crowding; D015716:Electrocardiography, Ambulatory; D006801:Humans; D009769:Object Attachment; D012933:Social Identification; D013177:Sports | Scientific reports | 2,022 | |
Morphological changes in spectral domain optical coherence tomography guided bevacizumab injections in wet age-related macular degeneration, 12-months results. | PURPOSE
To describe retinal changes during Spectral Domain Optical Coherence Tomography (SD-OCT) guided bevacizumab treatment for neovascular age- related macular degeneration (AMD).
SETTINGS AND DESIGN
Single center observational study.
MATERIALS AND METHODS
We confirmed wet AMD in 47 eyes of 45 patients by fluore... | 10.4103/0301-4738.133485 | 24,881,600 | D000368:Aged; D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D021621:Imaging, Three-Dimensional; D058449:Intravitreal Injections; D008268:Macular Degener... | Indian journal of ophthalmology | 2,014 | D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab |
Cocaine concentrations in the blood during rhinoplasty. | After applying 5% or 10% cocaine to the nasal mucosa, blood concentration were measured in 9 patients undergoing rhinoplasty and in 6 unoperated controls. The concentrations in the unoperated persons were lower than in those undergoing rhinoplasty, and lower concentrations were found after 5% solutions in both groups t... | 10.1097/00006534-197710000-00011 | 909,966 | D000281:Administration, Intranasal; D000772:Anesthesia, Local; D003042:Cocaine; D006801:Humans; D009297:Nasal Mucosa; D012225:Rhinoplasty | Plastic and reconstructive surgery | 1,977 | D003042:Cocaine |
Insights on conducting digital patient and public involvement in dementia research during the COVID-19 pandemic: supporting the development of an "E-nabling digital co-production" framework. | BACKGROUND
The rapid transition to digital working, accelerated due to the response to the COVID-19 pandemic, has impacted the involvement of patients and public in research. This paper presents experiences of engaging in digital Patient and Public Involvement (e-PPI) in dementia research since the lockdowns, offering ... | 10.1186/s40900-022-00371-9 | 35,883,132 | Research involvement and engagement | 2,022 |
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