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Evidence for Oxidative Pathways in the Pathogenesis of PD: Are Antioxidants Candidate Drugs to Ameliorate Disease Progression? | Parkinson's disease (PD) is a progressive neurodegenerative disorder that arises due to a complex and variable interplay between elements including age, genetic, and environmental risk factors that manifest as the loss of dopaminergic neurons. Contemporary treatments for PD do not prevent or reverse the extent of neuro... | 10.3390/ijms23136923 | 35,805,928 | D000818:Animals; D000975:Antioxidants; D018450:Disease Progression; D059290:Dopaminergic Neurons; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010300:Parkinson Disease | International journal of molecular sciences | 2,022 | D000975:Antioxidants |
Universal or targeted screening for fetal alcohol exposure: a cost-effectiveness analysis. | OBJECTIVE
In this article, we compared the costs of testing meconium for alcohol exposure in newborns with the lifetime benefits of early detection and intervention.
METHOD
A decision analytic model was developed to assess the cost-effectiveness of testing meconium for two scenarios: (1) all infants in the Canadian p... | 10.15288/jsad.2008.69.510 | 18,612,566 | D015415:Biomarkers; D003362:Cost-Benefit Analysis; D018479:Early Intervention, Educational; D005227:Fatty Acids; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008470:Meconium; D018803:Models, Economic; D015997:Neonatal Screening; D009864:Ontario; D0112... | Journal of studies on alcohol and drugs | 2,008 | D015415:Biomarkers; D005227:Fatty Acids |
Resveratrol loaded native silk fiber-sericin hydrogel double interpenetrating bioactive wound dressing facilitates full-thickness skin wound healing. | Wound repair is challenging for traditional wound dressings. New bioactive dressings need to be developed urgently. Herein, we reported a highly bioactive silk protein wound dressing (SPD) with natural silk fiber-sericin hydrogel interpenetrating double network structure, which combines the dual characteristics of natu... | 10.1088/1748-605X/acd318 | 37,146,618 | D051379:Mice; D000818:Animals; D047030:Sericins; D000077185:Resveratrol; D020100:Hydrogels; D042461:Vascular Endothelial Growth Factor A; D047011:Silk; D014945:Wound Healing; D012831:Bombyx; D001458:Bandages | Biomedical materials (Bristol, England) | 2,023 | D047030:Sericins; D000077185:Resveratrol; D020100:Hydrogels; D042461:Vascular Endothelial Growth Factor A; D047011:Silk |
Further decompensation in cirrhosis. Results of a large multicenter cohort study supporting Baveno VII statements. | BACKGROUND
The prognostic weight of further decompensation in cirrhosis is still unclear. We investigated the incidence of further decompensation and its effect on mortality in patients with cirrhosis.
METHODS
Multicenter cohort study. The cumulative incidence of further decompensation (development of a second event ... | 10.1097/HEP.0000000000000652 | 37,916,970 | Hepatology (Baltimore, Md.) | 2,023 | ||
Efficacy of Multiple Micronutrients Fortified Milk Consumption on Iron Nutritional Status in Moroccan Schoolchildren. | Iron deficiency constitutes a major public health problem in Morocco, mainly among women and children. The aim of our paper is to assess the efficacy of consumption of multiple micronutrients (MMN) fortified milk on iron status of Moroccan schoolchildren living in rural region. Children (N = 195), aged 7 to 9 y, were r... | 10.1155/2015/690954 | 26,355,324 | Journal of nutrition and metabolism | 2,015 | ||
Cage-Like Local Structure of Ionic Liquids Revealed by a (129)Xe Chemical Shift. | The chemical shift of xenon (at natural abundance) dissolved in a variety of 1-butyl-3-methylimidazolium-based ionic liquids (ILs) has been measured with (129)Xe NMR spectroscopy. The large chemical shift differences observed are mainly related to the type of anion; the strongest deshielding effect is observed ILs with... | 10.1021/jz400617v | 26,282,967 | The journal of physical chemistry letters | 2,013 | ||
Quantitative proteomic profiling of immune responses to Ichthyophthirius multifiliis in common carp skin mucus. | Ichthyophthirius multifiliis, a ciliated protozoan parasite, causes ichthyophthiriasis and leads to considerable economic losses to the aquaculture industry. Understanding the fish immune response and host-parasite interactions could support developing novel strategies for better disease management and control. Fish sk... | 10.1016/j.fsi.2018.10.078 | 30,385,245 | D000818:Animals; D002347:Carps; D016770:Ciliophora Infections; D005393:Fish Diseases; D029941:Fish Proteins; D016803:Hymenostomatida; D018928:Immunity, Mucosal; D020543:Proteome; D040901:Proteomics; D012876:Skin Diseases, Parasitic; D013047:Specific Pathogen-Free Organisms | Fish & shellfish immunology | 2,019 | D029941:Fish Proteins; D020543:Proteome |
Inverse scattering problem for mixed-phase and ice clouds. I. Numerical simulation of particle sizing from phase-function measurements. | We propose a new method of particle size retrieval for mixed-phase and ice crystal clouds. The method enables us to identify each component of a bicomponent cloud composed of water droplets and ice crystals and to retrieve a size distribution separately for each cloud component. We explore the method's capability by us... | 10.1364/ao.36.008765 | 18,264,426 | Applied optics | 1,997 | ||
Animal and plant factors which affect larkspur toxicosis in cattle: Sex, age, breed, and plant chemotype. | Larkspur (Delphinium spp.) poisoning is a long-term problem for cattle grazing on rangelands of western North America. Recent research has shown that both plant and animal-based factors are critical in understanding and mitigating larkspur poisoning in cattle. Non-toxicological factors including sex, age, cattle breed,... | 10.1016/j.toxicon.2019.04.013 | 31,029,637 | D000367:Age Factors; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases; D031882:Delphinium; D005260:Female; D008297:Male; D011041:Poisoning; D012307:Risk Factors; D012737:Sex Factors | Toxicon : official journal of the International Society on Toxinology | 2,019 | |
Changes in groundwater dissolved organic matter character in a coastal sand aquifer due to rainfall recharge. | Dissolved organic matter (DOM) in groundwater is fundamentally important with respect to biogeochemical reactions, global carbon cycling, heavy metal transport, water treatability and potability. One source of DOM to groundwater is from the transport of organic matter from the vadose zone by rainfall recharge. Changes ... | 10.1016/j.watres.2019.115201 | 31,675,607 | D001315:Australia; D060587:Groundwater; D006801:Humans; D009517:New South Wales; D000080463:Sand; D014881:Water Supply | Water research | 2,020 | D000080463:Sand |
Acidotoxicity in brain ischaemia. | Intracellular calcium toxicity remains the central feature in the pathophysiology of ischaemic cell death in brain. Glutamate-gated channels have been thought to be the major sites of ischaemia-induced toxic calcium entry, but the failure of glutamate antagonists in clinical trials has suggested that glutamate-independ... | 10.1042/BST0341356 | 17,073,818 | D062565:Acid Sensing Ion Channels; D000138:Acidosis; D000818:Animals; D001921:Brain; D002545:Brain Ischemia; D019556:COS Cells; D002118:Calcium; D016923:Cell Death; D002522:Chlorocebus aethiops; D005727:Ganglia, Spinal; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007473:Ion Channels; D008565:Membrane Proteins;... | Biochemical Society transactions | 2,006 | D062565:Acid Sensing Ion Channels; D007473:Ion Channels; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D015222:Sodium Channels; D002118:Calcium |
Inhibitor of DNA binding-1 overexpression in prostate cancer: relevance to tumor differentiation. | Inhibitor of DNA binding-1 (Id1) is a dominant-negative regulator of basic helix-loop-helix transcription factor, which control malignant cell behaviors in several types of carcinomas. This study aimed to find the relationship between Id1 expression and some clinical parameters. Paraffin-embedded tissue specimens from ... | 10.1007/s12253-008-9096-y | 18,752,043 | D000368:Aged; D014408:Biomarkers, Tumor; D002454:Cell Differentiation; D005455:Fluorescent Antibody Technique; D006801:Humans; D051798:Inhibitor of Differentiation Protein 1; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011470:Prostatic Hyperplasia; D011471:Prostatic Neoplasms; D012333:RNA, Messenger; D020133... | Pathology oncology research : POR | 2,009 | D014408:Biomarkers, Tumor; C497453:ID1 protein, human; D051798:Inhibitor of Differentiation Protein 1; D012333:RNA, Messenger |
The Epidemiology of Nationally Reported Pertussis in the United States, 2000-2016. | BACKGROUND
Despite successful vaccination programs, pertussis remains endemic in the United States, and increasing incidence has been reported. We used national surveillance data to describe pertussis epidemiology, including patient demographic characteristics, geographic distribution, and temporal trends.
METHODS
We... | 10.1093/cid/ciy757 | 30,169,627 | D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D019353:Endemic Diseases; D062665:Epidemiological Monitoring; D005260:Female; D005843:Geography; D006760:Hospitalization; D006801:Humans; D015994:Incide... | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | 2,019 | D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines |
Morphology of Australopithecus anamensis from Kanapoi and Allia Bay, Kenya. | The hominid species Australopithecus anamensis was originally described in 1995, with new specimens and more secure dates given in 1998. This paper lists all fossils attributed to A. anamensis, and provides anatomical descriptions of those not yet described in detail with photographs of all but undiagnostic fragments. ... | 10.1006/jhev.2001.0507 | 11,599,925 | D000818:Animals; D005580:Fossils; D015186:Hominidae; D006801:Humans; D007630:Kenya; D008334:Mandible; D008437:Maxilla; D010161:Paleodontology | Journal of human evolution | 2,001 | |
Recombinant Listeria promotes tumor rejection by CD8+ T cell-dependent remodeling of the tumor microenvironment. | Agents that remodel the tumor microenvironment (TME), prime functional tumor-specific T cells, and block inhibitory signaling pathways are essential components of effective immunotherapy. We are evaluating live-attenuated, double-deleted Listeria monocytogenes expressing tumor antigens (LADD-Ag) in the clinic. Here we ... | 10.1073/pnas.1801910115 | 30,038,013 | D000818:Animals; D000951:Antigens, Neoplasm; D018414:CD8-Positive T-Lymphocytes; D019496:Cancer Vaccines; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D008089:Listeria monocytogenes; D008264:Macrophages; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C... | Proceedings of the National Academy of Sciences of the United States of America | 2,018 | D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA |
Association of GALC, ZNF184, IL1R2 and ELOVL7 With Parkinson's Disease in Southern Chinese. | Study Objectives: The aim of the study was to investigate the relationship between 22 single nucleotide polymorphisms (SNPs) and Parkinson's disease (PD) in the Chinese population. Methods: A total of 250 PD patients and 240 healthy controls were recruited. The SNaPshot technique and the polymer chain reaction were use... | 10.3389/fnagi.2018.00402 | 30,618,709 | Frontiers in aging neuroscience | 2,018 | ||
New basic discoveries and frontiers in diagnosis, prognosis and prediction of response to therapy in human thyroid, urinary bladder, and prostate tumors. | The fourth edition of this workshop mainly focused on three different human oncotypes, which included thyroid, urinary bladder, and prostate tumors as clinical models to gain new basic knowledge on tumor diagnosis, prognosis, and treatment. At the previous editions (Giordano et al., 2000, J Cell Physiol 183:284-287; Gi... | 10.1002/jcp.10444 | 14,755,539 | D000818:Animals; D014408:Biomarkers, Tumor; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D011471:Prostatic Neoplasms; D013964:Thyroid Neoplasms; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms | Journal of cellular physiology | 2,004 | D014408:Biomarkers, Tumor |
Global Rotavirus and Pneumococcal Conjugate Vaccine Introductions and the Association With Country Disease Surveillance, 2006-2018. | BACKGROUND
To inform the introduction of pneumococcal conjugate vaccine (PCV) and rotavirus vaccine, the World Health Organization (WHO) established the Global Invasive Bacterial Vaccine-Preventable Disease Surveillance Network (GISN) and the Global Rotavirus Surveillance Network (GRSN) in 2008. We investigated whether... | 10.1093/infdis/jiab069 | 34,469,564 | D006801:Humans; D011008:Pneumococcal Infections; D022242:Pneumococcal Vaccines; D011159:Population Surveillance; D012401:Rotavirus; D012400:Rotavirus Infections; D022243:Rotavirus Vaccines; D018074:Vaccines, Conjugate | The Journal of infectious diseases | 2,021 | D022242:Pneumococcal Vaccines; D022243:Rotavirus Vaccines; D018074:Vaccines, Conjugate |
Assessment of distributed hydrological model performance for simulation of multi-heavy-metal transport in Harrach River, Algeria. | This paper aims to assess the performance of a distributed hydrological model for simulating the transport of various heavy metals in rivers, to enhance and support environmental monitoring strategies for rivers in developing countries. In this context, we evaluated the performance of the Geophysical flow Circulation (... | 10.2166/wst.2019.250 | 31,461,418 | D000462:Algeria; D002681:China; D004784:Environmental Monitoring; D019015:Geologic Sediments; D019216:Metals, Heavy; D008956:Models, Chemical; D018570:Risk Assessment; D045483:Rivers; D014874:Water Pollutants, Chemical | Water science and technology : a journal of the International Association on Water Pollution Research | 2,019 | D019216:Metals, Heavy; D014874:Water Pollutants, Chemical |
Identification of a new locus in the Escherichia coli cotransduction gap that represents a new genetic component of the L-asparagine utilization system. | A temperature-sensitive Escherichia coli mutant defective for the ability to utilize L-asparagine as a sole nitrogen source was isolated after N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis. The mutation (asu) produces two distinct phenotypic effects. Mutant strains grow poorly at high temperature on minimal plates c... | 10.1099/00221287-131-8-2079 | 3,903,041 | D001215:Asparaginase; D001216:Asparagine; D002874:Chromosome Mapping; D004926:Escherichia coli; D006358:Hot Temperature; D009154:Mutation; D014161:Transduction, Genetic | Journal of general microbiology | 1,985 | D001216:Asparagine; D001215:Asparaginase |
Subchronic inhalation toxicity of azinphos-methyl in rats. | Azinphos-methyl was evaluated for its subchronic inhalation toxicity. The exposure of rats to concentrations of 0.195, 1.24, and 4.72 mg/m3, respectively, for 12 weeks, 6 hrs daily, 5 times weekly, resulted in effects only in those animals which inhaled aerosols of the highest concentration. This group showed a signifi... | 10.1007/BF00372761 | 947,316 | D000336:Aerosols; D000393:Air Pollutants; D000818:Animals; D001387:Azinphosmethyl; D001835:Body Weight; D002802:Cholinesterases; D005260:Female; D007306:Insecticides; D008297:Male; D008452:Maximum Allowable Concentration; D051381:Rats | Archives of toxicology | 1,976 | D000336:Aerosols; D000393:Air Pollutants; D007306:Insecticides; D001387:Azinphosmethyl; D002802:Cholinesterases |
Adherence to a Mediterranean diet, dyslipidemia and inflammation in familial hypercholesterolemia. | BACKGROUND AND AIMS
Familial Hypercholesterolemia (FH) is characterized by elevated LDL-cholesterol (LDL-C) and high atherosclerosis risk. The impact of different dietary patterns on atherosclerosis biomarkers has been poorly studied in FH. This study verified the association of adherence to a Mediterranean diet with b... | 10.1016/j.numecd.2021.04.006 | 34,039,501 | D000328:Adult; D015415:Biomarkers; D001938:Brazil; D002318:Cardiovascular Diseases; D003430:Cross-Sectional Studies; D000072001:Diet, Healthy; D038441:Diet, Mediterranean; D005247:Feeding Behavior; D005260:Female; D000082742:Heart Disease Risk Factors; D006801:Humans; D006938:Hyperlipoproteinemia Type II; D007249:Infla... | Nutrition, metabolism, and cardiovascular diseases : NMCD | 2,021 | D015415:Biomarkers; D018836:Inflammation Mediators; D008055:Lipids |
[Isolation of Rec mutants of Bacillus subtilis via insertional mutagenesis]. | A number of mutants supersensitive to mytomycine C were isolated via insertion of Tn917 into Bacillus subtilis chromosome. Six Rec mutants with lower transformation frequency, though with nondisturbed capacity of DNA binding and uptake, were isolated. Two of these mutations are situated in those chromosomal sites where... | 1,651,879 | D001412:Bacillus subtilis; D002874:Chromosome Mapping; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D005798:Genes, Bacterial; D016685:Mitomycin; D008937:Mitomycins; D016254:Mutagenesis, Insertional; D009154:Mutation; D014170:Transformation, Genetic | Genetika | 1,991 | D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D008937:Mitomycins; D016685:Mitomycin | |
Continuous-flow left ventricular assist device systems infections: current outcomes and management strategies. | Left ventricular assisted devices (LVADs) are increasingly used for management of patients with advanced heart failure. However, infection remains one of the most commonly reported complications. Diagnosis, as well as treatment of LVAD infections is challenging. There are multiple diagnostic modalities that have been u... | 10.21037/acs-2020-cfmcs-26 | 33,842,217 | Annals of cardiothoracic surgery | 2,021 | ||
Clinical and functional outcome of the Thrust Plate Prosthesis: short- and medium-term results. | OBJECTIVES
The purpose of this study was to objectively assess the functional outcome after implantation of a Thrust Plate Prosthesis.
DESIGN
This retrospective study compared the gait patterns of 33 patients to a control group.
BACKGROUND
Few studies have been published about this type of prosthesis describing cli... | 10.1016/s0268-0033(03)00092-5 | 12,880,712 | D000203:Activities of Daily Living; D004576:Electromyography; D019544:Equipment Failure Analysis; D005260:Female; D005684:Gait; D006621:Hip Joint; D006622:Hip Prosthesis; D006801:Humans; D021621:Imaging, Three-Dimensional; D007593:Joint Instability; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D011788... | Clinical biomechanics (Bristol, Avon) | 2,003 | |
The automated CBC. A current perspective. | CBC traditionally stands for complete blood count. It represents a profile of tests rather than a single test, and over the years it has been given several names, including hemogram, Coulter profile, blood cell profile, and hematology profile. The number and type of tests included in the profile has also changed over t... | 7,961,282 | D001322:Autoanalysis; D001772:Blood Cell Count; D001800:Blood Specimen Collection; D006801:Humans | Hematology/oncology clinics of North America | 1,994 | ||
Determinants of incomplete vaccination among children 12-23 months in Nigeria: An analysis of a national sample. | Objectives
The study aimed to assess the prevalence and the determinants of incomplete childhood vaccination in Nigeria.
Materials and Methods
The data for this study was the 2018 Nigeria Demographic and Health Survey. Multivariable multilevel logistic regression analysis techniques using Stata statistical software (... | 10.4103/tcmj.tcmj_220_21 | 36,578,641 | Tzu chi medical journal | 2,022 | ||
Riboflavin photosensitized oxidation of 2,4-dichlorophenol: assessment of possible chlorinated dioxin formation. | Dimeric products are formed by riboflavin-sensitized photooxidation of 2,4-dichlorophenol. The products of this reaction were examined to determine whether chlorinated dibenzo-p-dioxins could be formed from chlorophenols in water by the action of light of wavelengths greater than 280 nanometers. Dimers are formed by un... | 10.1126/science.174.4007.407 | 5,111,992 | D015084:2,4-Dichlorophenoxyacetic Acid; D002855:Chromatography, Thin Layer; D004147:Dioxins; D006540:Herbicides; D010084:Oxidation-Reduction; D010636:Phenols; D010777:Photochemistry; D010782:Photolysis; D012256:Riboflavin; D013057:Spectrum Analysis | Science (New York, N.Y.) | 1,971 | D004147:Dioxins; D006540:Herbicides; D010636:Phenols; D015084:2,4-Dichlorophenoxyacetic Acid; D012256:Riboflavin |
Glomerular disease workshop. | Recent observations regarding intrinsic glomerular cell biology, particularly in the podocyte, have provided exciting new insights into potential pathogenic mechanisms of human glomerular disease. Although both immune and nonimmune mechanisms of glomerular injury have been studied previously, experimental models of dis... | 10.1681/ASN.2005090899 | 16,267,152 | D000818:Animals; D015415:Biomarkers; D002986:Clinical Trials as Topic; D020022:Genetic Predisposition to Disease; D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis; D006801:Humans; D007678:Kidney Glomerulus; D008967:Molecular Biology; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012680:Sensiti... | Journal of the American Society of Nephrology : JASN | 2,005 | D015415:Biomarkers |
Psychosocial aspects of truancy in early adolescence. | The authors studied truancy in junior high school students, largely by structured interviews of 33 truants. Truancy at this age was commonly associated with significant difficulties at home, at school and with peers. Two modal types of truants were delineated: "authority defying" and "peer phobic." The school environme... | 314,732 | D000041:Absenteeism; D000293:Adolescent; D002653:Child Behavior Disorders; D003430:Cross-Sectional Studies; D005190:Family; D005260:Female; D006801:Humans; D007604:Juvenile Delinquency; D008297:Male; D010379:Peer Group; D012574:Schools; D012917:Social Adjustment; D012923:Social Class; D012931:Social Environment; D01331... | Adolescence | 1,979 | ||
Thymic stromal lymphopoietin (TSLP) secretion from human nasal epithelium is a function of TSLP genotype. | Recent candidate gene and genome-wide association studies have identified "protective" associations between the single-nucleotide polymorphism (SNP) rs1837253 in the TSLP gene and risk for allergy, asthma, and airway hyperresponsiveness. The absence of linkage disequilibrium of rs1837253 with other SNPs in the region s... | 10.1038/mi.2014.126 | 25,515,628 | D000293:Adolescent; D000328:Adult; D000483:Alleles; D016207:Cytokines; D004847:Epithelial Cells; D005260:Female; D055106:Genome-Wide Association Study; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D006967:Hypersensitivity; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa; D020641:Polymorphism, Singl... | Mucosal immunology | 2,015 | D016207:Cytokines; D012330:RNA, Double-Stranded; D000094632:Thymic Stromal Lymphopoietin |
[Reconstruction of the lateral ankle ligaments with hamstring tendon autograft in patients with chronic ankle instability]. | OBJECTIVE
Reconstruction of the anterior talofibular (ATFL) and calcaneofibular (CFL) ligament in patients with chronic lateral ankle instability.
INDICATIONS
Symptomatic chronic lateral ankle instability.
CONTRAINDICATIONS
Bony malalignment, advanced arthritic changes of the ankle joint, diabetic foot syndrome.
... | 10.1007/s00064-011-0126-7 | 22,270,880 | D000293:Adolescent; D000328:Adult; D016512:Ankle Injuries; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007593:Joint Instability; D017844:Lateral Ligament, Ankle; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011859:Radiography; D016059:Range of Motion, Articular; D013180:Sprai... | Operative Orthopadie und Traumatologie | 2,012 | |
Neuroendocrine evaluation of cardiac disease. | Current evidence favors the view that regardless of etiology, there is a predictable sequence of neuroendocrine activation that operates in most dogs and cats with progressive heart disease and that it is largely, but not entirely, independent of etiology. The natriuretic peptides and sympathetic nervous system seem to... | 10.1016/j.cvsm.2004.05.005 | 15,325,472 | D000818:Animals; D001774:Blood Chemical Analysis; D002371:Cat Diseases; D002415:Cats; D004283:Dog Diseases; D004285:Dogs; D006333:Heart Failure; D036361:Peptide Hormones; D012084:Renin-Angiotensin System | The Veterinary clinics of North America. Small animal practice | 2,004 | D036361:Peptide Hormones |
Marijuana: respiratory tract effects. | Marijuana is the most commonly used drug of abuse in the USA. It is commonly abused through inhalation and therefore has effects on the lung that are similar to tobacco smoke, including increased cough, sputum production, hyperinflation, and upper lobe emphysematous changes. However, at this time, it does not appear th... | 10.1007/s12016-013-8374-y | 23,715,638 | D000818:Animals; D001986:Bronchial Spasm; D002188:Cannabis; D002490:Central Nervous System; D006801:Humans; D007107:Immune System; D008385:Marijuana Smoking; D043882:Receptors, Cannabinoid; D012137:Respiratory System; D012907:Smoking | Clinical reviews in allergy & immunology | 2,014 | D043882:Receptors, Cannabinoid |
Striatal dopamine and the temporal control of behavior. | Striatal dopamine strongly regulates how individuals use time to guide behavior. Dopamine acts on D1- and D2- dopamine receptors in the striatum. However, the relative role of these receptors in the temporal control of behavior is unclear. To assess this, we trained rats on a task in which they decided to start and sto... | 10.1016/j.bbr.2018.08.030 | 30,213,664 | D000818:Animals; D001522:Behavior, Animal; D003342:Corpus Striatum; D004298:Dopamine; D018492:Dopamine Antagonists; D008297:Male; D017072:Neostriatum; D009415:Nerve Net; D020318:Rats, Long-Evans; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2 | Behavioural brain research | 2,019 | D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D004298:Dopamine |
Role of high dose rate brachytherapy in the treatment of prostate cancer. | High dose rate (HDR) brachytherapy in intermediate and high-risk prostate cancer patients has started in the late eighties in Europe and the United States, as a boost combined with external beam radiation therapy, as an attractive method for dose escalation. The results of the first dose-escalation study performed at W... | 22,925,490 | D001918:Brachytherapy; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms; D011879:Radiotherapy Dosage | Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique | 2,012 | ||
Optical frequency upconversion technique for transmission of wireless MIMO-type signals over optical fiber. | The optical fiber is well adapted to pass multiple wireless signals having different carrier frequencies by using radio-over-fiber (ROF) technique. However, multiple wireless signals which have the same carrier frequency cannot propagate over a single optical fiber, such as wireless multi-input multi-output (MIMO) sign... | 10.1155/2014/170471 | 24,772,009 | D000465:Algorithms; D004867:Equipment Design; D005336:Fiber Optic Technology; D008962:Models, Theoretical; D055100:Optical Fibers; D011846:Radio Waves; D013685:Telecommunications; D059015:Wireless Technology | TheScientificWorldJournal | 2,014 | |
Basal Mild Dehydration Increase Salivary Cortisol After a Friendly Match in Young Elite Soccer Players. | A soccer match induce changes in physiological stress biomarkers as testosterone (T), cortisol (C), and testosterone:cortisol (T:C) ration. Hydration state may also modulate these hormones, and therefore may alter the anabolic/catabolic balance in response to soccer match. The role of hydration status before the match ... | 10.3389/fphys.2018.01347 | 30,319,450 | Frontiers in physiology | 2,018 | ||
Oxygen matters: tissue culture oxygen levels affect mitochondrial function and structure as well as responses to HIV viroproteins. | Mitochondrial dysfunction is implicated in a majority of neurodegenerative disorders and much study of neurodegenerative disease is done on cultured neurons. In traditional tissue culture, the oxygen level that cells experience is dramatically higher (21%) than in vivo conditions (1-11%). These differences can alter ex... | 10.1038/cddis.2011.128 | 22,190,005 | D000255:Adenosine Triphosphate; D017209:Apoptosis; D002478:Cells, Cultured; D015696:Gene Products, tat; D006678:HIV; D006801:Humans; D018613:Microscopy, Confocal; D008928:Mitochondria; D009474:Neurons; D010100:Oxygen; D010456:Peptides, Cyclic; D017382:Reactive Oxygen Species; D054311:nef Gene Products, Human Immunodefi... | Cell death & disease | 2,011 | D015696:Gene Products, tat; D010456:Peptides, Cyclic; D017382:Reactive Oxygen Species; D054311:nef Gene Products, Human Immunodeficiency Virus; C026460:virotoxins; D000255:Adenosine Triphosphate; D010100:Oxygen |
Hematologic neoplasia associated with primary mediastinal germ-cell tumors. | Between September 1983 and December 1988, we observed 16 cases of hematologic neoplasia associated with mediastinal germ-cell tumors. Twenty-eight similar cases have been reported in the literature. A review of the clinical and cytogenetic details in these patients suggests that the hematologic neoplasia is not the res... | 10.1056/NEJM199005173222004 | 2,158,625 | D000293:Adolescent; D000328:Adult; D001855:Bone Marrow Diseases; D002648:Child; D002881:Chromosomes, Human, Pair 12; D006402:Hematologic Diseases; D054747:Histiocytic Sarcoma; D006801:Humans; D007938:Leukemia; D007947:Leukemia, Megakaryoblastic, Acute; D008479:Mediastinal Neoplasms; D008875:Middle Aged; D009373:Neoplas... | The New England journal of medicine | 1,990 | |
Bilateral modified V-Y advancement flaps for closing meningomyelocele defects. | Various reports describe surgical techniques for closing a meningomyelocele defect. We have used a combination flap consisting of a vertical bipedicled flap and V-Y advancement flap and used this technique in the successful repair of 11 meningomyelocele defects. The vertical bipedicled flap enhances the blood supply to... | 10.1097/01.sap.0000215281.05153.0c | 16,862,002 | D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008591:Meningomyelocele; D019651:Plastic Surgery Procedures; D013524:Surgical Flaps | Annals of plastic surgery | 2,006 | |
Neighborhood variations in the use of city-supported primary health care services by an elderly population. | The purpose of this paper is to examine the elderly's use of city-supported primary health care services. The provision of free or low cost health care to the elderly population is a major health policy issue, especially as the size of the elderly population increases and there is a concomitant increase in the need for... | 10.1007/BF01324293 | 3,429,709 | D001741:Black or African American; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003153:Community Health Services; D005260:Female; D006301:Health Services Needs and Demand; D006306:Health Surveys; D006801:Humans; D007182:Income; D008297:Male; D010414:Pennsylvania; D012737:Sex Factors; D014505:Urban Pop... | Journal of community health | 1,987 | |
Bioactivity of medicinal plant extracts against human fungal pathogens and evaluation of toxicity using Vero cells. | Medicinal plants are a potential source of new antifungal agents to combat the development of drug-resistant fungi. This study aims to investigate the aerial parts of Alternanthera sessilis (Amaranthaceae) and Ipomoea aquatica (Convolvulaceae), and the leaves of Catunaregam spinosa (Rubiaceae) and Tradescantia spathace... | 10.47665/tb.38.3.090 | 34,608,121 | D027703:Amaranthaceae; D000818:Animals; D000935:Antifungal Agents; D002522:Chlorocebus aethiops; D005658:Fungi; D027741:Ipomoea; D008826:Microbial Sensitivity Tests; D035261:Plant Components, Aerial; D010936:Plant Extracts; D010946:Plants, Medicinal; D019666:Rubiaceae; D018675:Toxicity Tests; D034823:Tradescantia; D014... | Tropical biomedicine | 2,021 | D000935:Antifungal Agents; D010936:Plant Extracts |
Benefit of a high-dose epirubicin regimen in adjuvant chemotherapy for node-positive breast cancer patients with poor prognostic factors: 5-year follow-up results of French Adjuvant Study Group 05 randomized trial. | PURPOSE
To determine the influence of the epirubicin dose in operable node-positive breast cancer patients with factors of poor prognosis.
PATIENTS AND METHODS
Between April 1990 and July 1993, 565 operable breast cancer patients with either more than three positive nodes or between one and three positive nodes with ... | 10.1200/JCO.2001.19.3.602 | 11,157,009 | D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols; D001943:Breast Neoplasms; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide; D018572:Disease-Free Survival; D004305:Dose-Response Relationship, Drug; D015251:Epirubicin; D005260:Female; D005472:Fluorouracil; D005500:Follow-Up St... | Journal of clinical oncology : official journal of the American Society of Clinical Oncology | 2,001 | D015251:Epirubicin; D003520:Cyclophosphamide; D005472:Fluorouracil |
Biomedical Ti-Nb-Zr Foams Prepared by Means of Thermal Dealloying Process and Electrochemical Modification. | The paper presents results of preparation and modification of Ti20Nb5Zr foams by a thermal dealloying method followed by electrochemical modification. The first step of this study was the preparation of Ti20Nb5Zr30Mg nanopowder using mechanical alloying (MA). The second was forming green compacts by cold pressing and t... | 10.3390/ma15062130 | 35,329,580 | Materials (Basel, Switzerland) | 2,022 | ||
Custom allogeneic block graft for ridge augmentation: Case series. | INTRODUCTION
Alveolar bone deficiency is a common postextraction sequela that adversely affects implant placement. Therefore, ridge augmentation is often required to obtain proper bone quantity and quality for restoratively driven implant placement. This case series describes the successful horizontal and vertical alve... | 10.1002/cap.10183 | 34,435,754 | D006801:Humans; D015921:Dental Implants; D003758:Dental Implantation, Endosseous; D011446:Prospective Studies; D004955:Esthetics, Dental; D018380:Hematopoietic Stem Cell Transplantation | Clinical advances in periodontics | 2,023 | D015921:Dental Implants |
The viability of microorganisms in carious lesions five years after covering with a fissure sealant. | Carious lesions that were covered with a pit and fissure sealant for five years yielded bacterial cultures that were predominantly negative. Sixteen of 18 test sites judged to have active caries in 1972 were found inactive in 1977; ten of 12 sites suspected to have caries in 1972 were deemed to have inactive caries in ... | 10.14219/jada.archive.1978.0327 | 279,600 | D000134:Acid Etching, Dental; D000293:Adolescent; D001419:Bacteria; D002327:Cariostatic Agents; D002648:Child; D003731:Dental Caries; D003743:Dental Enamel; D003764:Dental Materials; D003804:Dentin; D005069:Evaluation Studies as Topic; D006801:Humans; D007778:Lactobacillus; D008137:Longitudinal Studies; D008689:Methacr... | Journal of the American Dental Association (1939) | 1,978 | D002327:Cariostatic Agents; D003764:Dental Materials; D008689:Methacrylates; D010895:Pit and Fissure Sealants |
The RNA polymerase I transcription factor UBF is a sequence-tolerant HMG-box protein that can recognize structured nucleic acids. | Upstream Binding Factor (UBF) is important for activation of ribosomal RNA transcription and belongs to a family of proteins containing nucleic acid binding domains, termed HMG-boxes, with similarity to High Mobility Group (HMG) chromosomal proteins. Proteins in this family can be sequence-specific or highly sequence-t... | 10.1093/nar/22.13.2651 | 8,041,627 | D000818:Animals; D001483:Base Sequence; D014128:Chromomycin A3; D004247:DNA; D004268:DNA-Binding Proteins; D003609:Dactinomycin; D004214:Distamycins; D004742:Enhancer Elements, Genetic; D006609:High Mobility Group Proteins; D008745:Methylation; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D035463... | Nucleic acids research | 1,994 | D004268:DNA-Binding Proteins; D004214:Distamycins; D006609:High Mobility Group Proteins; D035463:Pol1 Transcription Initiation Complex Proteins; D014157:Transcription Factors; C063844:transcription factor UBF; D003609:Dactinomycin; C030000:stallimycin; D004247:DNA; D012343:RNA, Transfer; D014128:Chromomycin A3; D012318... |
Programmable Clostridium perfringens Argonaute-Based, One-Pot Assay for the Multiplex Detection of miRNAs. | Assays for the molecular detection of miRNAs are typically constrained by the level of multiplexing, especially in a single tube. Here, we report a general and programmable diagnostic platform by combining mesophilic Clostridium perfringens Argonaute (CpAgo) with exponential isothermal amplification (EXPAR), which is a... | 10.1021/acs.analchem.3c01990 | 37,565,811 | D006801:Humans; D035683:MicroRNAs; D003016:Clostridium perfringens; D009711:Nucleotides; D021141:Nucleic Acid Amplification Techniques | Analytical chemistry | 2,023 | D035683:MicroRNAs; D009711:Nucleotides |
The Ret(C620R) mutation affects renal and enteric development in a mouse model of Hirschsprung's disease. | In rare families RET tyrosine kinase receptor substitutions located in exon 10 (especially at positions 609, 618, and 620) can concomitantly cause the MEN 2A (multiple endocrine neoplasia type 2A) or FMTC (familial medullary thyroid carcinoma) cancer syndromes, and Hirschsprung's disease (HSCR). No animal model mimicki... | 10.2353/ajpath.2006.050607 | 16,565,500 | D019943:Amino Acid Substitution; D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D017615:Enteric Nervous System; D005260:Female; D005727:Ganglia, Spinal; D041981:Gastrointestinal Tract; D006627:Hirschsprung Disease; D007668:Kidney; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D051... | The American journal of pathology | 2,006 | D051096:Proto-Oncogene Proteins c-ret; C494999:Ret protein, mouse |
DNA breakage upon K-shell excitation of phosphorus as a model for direct effects in radiation biology. | Single-strand breaks (SSBs) and double-strand breaks (DSBs) induced in DNA under phosphorus K-shell resonant absorption have been studied using supercoiled plasmids. The kinetics of the production of SSBs and DSBs exhibits a linear and a quadratic dependence, respectively, on photon fluence. Cross sections and quantum ... | 8,619,030 | D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D008954:Models, Biological; D010758:Phosphorus; D017785:Photons; D010957:Plasmids; D012044:Regression Analysis | Radiation research | 1,996 | D010758:Phosphorus | |
Inhibition of hippocampal long-term potentiation by high-fat diets: is it related to an effect of palmitic acid involving glycogen synthase kinase-3? | High-fat diets (HFD) impair hippocampal-dependent learning and memory and produce important changes in synaptic transmission by enhancing glutamate uptake, decreasing synaptic efficacy, and inhibiting plasticity mechanisms such as N-methyl-D-aspartate-mediated long-term depression (LTD) within the hippocampus. Adolesce... | 10.1097/WNR.0000000000000774 | 28,328,738 | D000818:Animals; D059305:Diet, High-Fat; D004558:Electric Stimulation; D019706:Excitatory Postsynaptic Potentials; D038362:Glycogen Synthase Kinase 3; D006624:Hippocampus; D017774:Long-Term Potentiation; D036881:Long-Term Synaptic Depression; D008297:Male; D008810:Mice, Inbred C57BL; D016202:N-Methylaspartate; D018696:... | Neuroreport | 2,017 | D018696:Neuroprotective Agents; D047428:Protein Kinase Inhibitors; D013830:Thiadiazoles; D019308:Palmitic Acid; D016202:N-Methylaspartate; D038362:Glycogen Synthase Kinase 3; C520571:tideglusib |
Variation in hominoid molar enamel thickness. | Enamel thickness has figured prominently in discussions of hominid origins for nearly a century, although little is known about its intra-taxon variation. It has been suggested that enamel thickness increases from first to third molars, perhaps due to varying functional demands or developmental constraints, but this ha... | 10.1016/j.jhevol.2005.02.004 | 15,927,661 | D000818:Animals; D003743:Dental Enamel; D006071:Gorilla gorilla; D015186:Hominidae; D006801:Humans; D008963:Molar; D009811:Odontometry; D002679:Pan troglodytes; D011148:Pongo pygmaeus | Journal of human evolution | 2,005 | |
Energy transfer cassettes for facile labeling of sequencing and PCR primers. | Fluorescence energy transfer (ET) primers and terminators are the reagents of choice for multiplex DNA sequencing and analysis. We present here the design, synthesis and evaluation of a four-color set of ET cassettes, fluorescent labeling reagents that can be quantitatively coupled to a thiol-activated target through a... | 10.1006/abio.2001.5069 | 11,355,850 | D002851:Chromatography, High Pressure Liquid; D003116:Color; D017931:DNA Primers; D004220:Disulfides; D019075:Electrophoresis, Capillary; D004735:Energy Transfer; D005453:Fluorescence; D005456:Fluorescent Dyes; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D... | Analytical biochemistry | 2,001 | D017931:DNA Primers; D004220:Disulfides; D005456:Fluorescent Dyes |
Soybean glycinin and β-conglycinin damage the intestinal barrier by triggering oxidative stress and inflammatory response in weaned piglets. | PURPOSE
Soybean glycinin (11S) and β-conglycinin (7S) are major antigenic proteins in soybean and can induce a variety of allergic reactions in the young animals. This study aimed to investigate the effect of 7S and 11S allergens on the intestine of piglets.
METHODS
Thirty healthy 21-day-old weaned "Duroc × Long Whit... | 10.1007/s00394-023-03188-8 | 37,358,571 | D000818:Animals; D013552:Swine; D013025:Glycine max; D030262:Soybean Proteins; D007422:Intestines; D005916:Globulins; D018384:Oxidative Stress; D006967:Hypersensitivity | European journal of nutrition | 2,023 | C011474:glycinin; C013894:beta-conglycinin protein, Glycine max; D030262:Soybean Proteins; D005916:Globulins |
Combined Use of Excimer Laser and High-Speed Rotational Atherectomy to Overcome a Severely Calcified Lesion in Endovascular Therapy. | Although endovascular therapy (EVT) is commonly used in treatment of peripheral artery disease (PAD), severely calcified lesions pose a challenge, in spite of the technical advancement. In this report, we discuss the case of a 74-year-old male with coronary artery disease and end-stage renal disease who presented at ou... | 10.1155/2019/1719035 | 31,139,490 | Case reports in vascular medicine | 2,019 | ||
Widespread geographical disparities in chronic hepatitis B virus infection in Algeria. | Algeria is the largest country of Africa, with a population of 40 million inhabitants living in disparate environments from the Sahara to the large cities of the Mediterranean coast. The molecular epidemiology of hepatitis B virus (HBV) variants has been partially described, but variations in the seroprevalence of HBV ... | 10.1007/s00705-017-3284-6 | 28,236,070 | D000328:Adult; D000462:Algeria; D004279:DNA, Viral; D005260:Female; D005843:Geography; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic; D006801:Humans; D008297:Male; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D016036:Se... | Archives of virology | 2,017 | D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens |
Urinary tract infections in the surgical patient. | Urinary tract infection (UTI) continues to be a common nosocomial infection. From a 2-year city-county hospital experience, 212 nosocomial UTI were identified in 153 patients from 3747 admissions. Mean age was 54 years; 102 were men. Foley catheterization was an associated factor in 129 patients (84%). UTI was caused b... | 3,389,599 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents; D002408:Catheters, Indwelling; D003428:Cross Infection; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011292:Premedication; D012008:Recurrence; D014546:Urinary Catheterization; D014... | The American surgeon | 1,988 | D000900:Anti-Bacterial Agents | |
Partial enterectomy decreases somatostatin-binding sites in residual intestine of rabbits. | 1. Three weeks after partial enterectomy in the rabbit there was an increased somatostatin concentration and a decreased number of somatostatin-binding sites (without changes in the corresponding affinity values) in the cytosol of the residual intestinal tissue, except in the terminal ileum and the colon. 2. Five weeks... | 10.1042/cs0740499 | 2,897,266 | D000818:Animals; D003600:Cytosol; D007413:Intestinal Mucosa; D007420:Intestine, Large; D007421:Intestine, Small; D007422:Intestines; D008297:Male; D011817:Rabbits; D017981:Receptors, Neurotransmitter; D017481:Receptors, Somatostatin; D013004:Somatostatin | Clinical science (London, England : 1979) | 1,988 | D017981:Receptors, Neurotransmitter; D017481:Receptors, Somatostatin; D013004:Somatostatin |
Second virial coefficients of dipolar hard spheres. | An asymptotic formula is reported for the second virial coefficient B(2) of a dipolar hard-sphere (DHS) fluid, in zero external field, for strongly coupled dipolar interactions. This simple formula, together with the one for the weak-coupling B(2), provides an accurate prediction of the second virial coefficient for a ... | 10.1088/0953-8984/22/32/325104 | 21,386,486 | Journal of physics. Condensed matter : an Institute of Physics journal | 2,010 | ||
The salivary chaperone protein NlDNAJB9 of Nilaparvata lugens activates plant immune responses. | The brown planthopper (BPH) Nilaparvata lugens (Stål) is a main pest on rice. It secretes saliva to regulate plant defense responses, when penetrating rice plant and sucking phloem sap through its stylet. However, the molecular mechanisms of BPH salivary proteins regulating plant defense responses remain poorly underst... | 10.1093/jxb/erad154 | 37,103,882 | D000818:Animals; D017382:Reactive Oxygen Species; D012463:Saliva; D006430:Hemiptera; D057865:Plant Immunity; D012471:Salivary Proteins and Peptides; D012275:Oryza | Journal of experimental botany | 2,023 | D017382:Reactive Oxygen Species; D012471:Salivary Proteins and Peptides |
Therapeutic relevance of mTOR inhibition in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism. | Aldehyde dehydrogenase 5a1-deficient (aldh5a1-/-) mice, the murine orthologue of human succinic semialdehyde dehydrogenase deficiency (SSADHD), manifest increased GABA (4-aminobutyric acid) that disrupts autophagy, increases mitochondria number, and induces oxidative stress, all mitigated with the mTOR (mechanistic tar... | 10.1016/j.bbadis.2016.10.009 | 27,760,377 | D000592:Amino Acid Metabolism, Inborn Errors; D000818:Animals; D002658:Developmental Disabilities; D004195:Disease Models, Animal; D005260:Female; D017353:Gene Deletion; D005978:Glutathione; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009287:Naphthyridines; D018384:Oxidative Stress; D015398:Signal Transduc... | Biochimica et biophysica acta. Molecular basis of disease | 2,017 | C553294:1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one; C558529:9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one; D009287:Naphthyridines; D005680:gamma-Aminobutyric Acid; C520316:Aldh5a1 protein, mouse; D050644:Suc... |
[Peripheral nervous system in limited systemic sclerosis]. | OBJECTIVES
PNS is involved in Systemic Sclerosis (SSc) since the earliest phases. Our aim is to perform an ultrastructural study on skin PNS fibers in SSc.
METHODS
Skin biopsies were taken from forearms of 8 patients affected by limited SSc (lSSc) and 3 controls and processed for transmission electron microscopy (TEM... | 10.4081/reumatismo.2004.247 | 15,643,479 | D001706:Biopsy; D016009:Chi-Square Distribution; D003627:Data Interpretation, Statistical; D005260:Female; D005355:Fibrosis; D016591:Histocytological Preparation Techniques; D006801:Humans; D008297:Male; D008833:Microcirculation; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D009412:Nerve Fibers; D01... | Reumatismo | 2,004 | |
CD99-like 2 (CD99L2)-deficient mice are defective in the acute inflammatory response. | CD99-Like 2 (CD99L2) is a Type I glycoprotein expressed on leukocytes and endothelial cells as well as other cell types. It is related to CD99, although it shows only 38% sequence identity. CD99L2 has been shown to play a role in leukocyte extravasation in mice under various inflammatory conditions using anti-CD99L2 an... | 26,321,243 | D000071443:12E7 Antigen; D000208:Acute Disease; D000818:Animals; D015703:Antigens, CD; D002448:Cell Adhesion; D002465:Cell Movement; D042783:Endothelial Cells; D004730:Endothelium, Vascular; D007249:Inflammation; D018799:Intercellular Adhesion Molecule-1; D007962:Leukocytes; D018345:Mice, Knockout; D009504:Neutrophils | Experimental and molecular pathology | 2,015 | D000071443:12E7 Antigen; D015703:Antigens, CD; C522605:Cd99 protein, mouse; D018799:Intercellular Adhesion Molecule-1 | |
Risk factors and mortality among patients with severe muco-cutaneous drug reactions. | INTRODUCTION
The aim of this study was to examine risk factors and mortality among patients with erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).
METHODS
This was a retrospective evaluation of the med-ical records of 250 patients from two Danish tertiary dermatological de... | 26,239,591 | D000328:Adult; D000493:Allopurinol; D000900:Anti-Bacterial Agents; D000963:Antimetabolites; D003718:Denmark; D004892:Erythema Multiforme; D005260:Female; D006561:Herpes Simplex; D006801:Humans; D008297:Male; D008875:Middle Aged; D011019:Pneumonia, Mycoplasma; D016016:Proportional Hazards Models; D012189:Retrospective S... | Danish medical journal | 2,015 | D000900:Anti-Bacterial Agents; D000963:Antimetabolites; D000493:Allopurinol | |
[Acute pain in "Don Quixote"]. | OBJECTIVE
A descriptive analysis of references to pain symptoms in Don Quixote based on linguistic, literary, clinical, and mannerist features.
METHODS AND MATERIAL
Don Quixote was read and an entry was created for each description of an injury or illness (group I/I). A second group of entries was created for each me... | 14,552,107 | D000208:Acute Disease; D006801:Humans; D007802:Language; D008093:Literature, Modern; D008513:Medicine in Literature; D010146:Pain; D059408:Pain Management; D013030:Spain; D014947:Wounds and Injuries | Revista espanola de anestesiologia y reanimacion | 2,003 | ||
Weighted correlation approach: an extended version with applications to the hard-sphere fluid. | The purpose of this study is to extend the weighted correlation approach (WCA) for inhomogeneous fluids. It now introduces a generic expression to evaluate the single-particle direct correlation function in terms of a series of pair direct correlation functions weighted by different correlation-weight functions and adj... | 10.1103/PhysRevE.86.031115 | 23,030,874 | Physical review. E, Statistical, nonlinear, and soft matter physics | 2,012 | ||
Delivery of oncolytic adenovirus into the nucleus of tumorigenic cells by tumor microparticles for virotherapy. | Oncolytic viruses have been utilized for the treatment of various cancers. However, delivery of the viral particles to tumor cells remains a major challenge. Microparticles (MP) are vesicle forms of plasma membrane fragments of 0.1-1 μm in size that are shed by cells. We have previously shown the delivery of chemothera... | 26,950,165 | D000256:Adenoviridae; D000818:Animals; D045744:Cell Line, Tumor; D055252:Cell-Derived Microparticles; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D009369:Neoplasms; D050130:Oncolytic Virotherapy; D050504:Oncolytic Vir... | Biomaterials | 2,016 | D004337:Drug Carriers | |
Control of flagellar bending: a new agenda based on dynein diversity. | Observations that were interpreted to provide evidence for equivalent functions of all axonemal dyneins should be reinterpreted, and models based on this assumption should be abandoned. In the future, attempts to understand the mechanisms for flagellar bending, oscillation, and bend propagation should start from the as... | 10.1002/cm.970280303 | 7,954,848 | D000818:Animals; D003198:Computer Simulation; D004398:Dyneins; D005407:Flagella; D006801:Humans | Cell motility and the cytoskeleton | 1,994 | D004398:Dyneins |
17beta-estradiol rapidly facilitates chemoinvestigation and mounting in castrated male rats. | Testosterone and estradiol act synergistically to stimulate male sexual behavior. Previous studies demonstrated that testosterone's actions are mediated genomically. Attempts to show that estradiol acts in a similar fashion have been inconclusive. However, estrogens have been shown to exert short-latency effects by act... | 10.1152/ajpregu.1999.276.5.R1346 | 10,233,026 | D000818:Animals; D018931:Antineoplastic Agents, Hormonal; D003307:Copulation; D004305:Dose-Response Relationship, Drug; D004958:Estradiol; D005260:Female; D008297:Male; D009919:Orchiectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D013739:Testosterone | The American journal of physiology | 1,999 | D018931:Antineoplastic Agents, Hormonal; D013739:Testosterone; D004958:Estradiol |
A fast continuous time approach with time scaling for nonsmooth convex optimization. | In a Hilbert setting, we study the convergence properties of the second order in time dynamical system combining viscous and Hessian-driven damping with time scaling in relation to the minimization of a nonsmooth and convex function. The system is formulated in terms of the gradient of the Moreau envelope of the object... | 10.1186/s13662-022-03744-2 | 36,540,365 | Advances in continuous and discrete models | 2,022 | ||
Management of Critically Ill Patients with Severe Acute Respiratory Syndrome (SARS). | Severe acute respiratory syndrome (SARS) is frequently complicated with acute respiratory failure. In this article, we aim to focus on the management of the subgroup of SARS patients who are critically ill. Most SARS patients would require high flow oxygen supplementation, 20-30% required intensive care unit (ICU) or h... | 10.7150/ijms.1.1 | 15,912,185 | International journal of medical sciences | 2,004 | ||
Microsatellite DNA polymorphism and heterozygosity in the malaria vector mosquito Anopheles funestus (Diptera: Culicidae) in east and southern Africa. | There has been an increase in malaria cases in southern African countries in recent years due to the presence of populations of Anopheles funestus that are resistant to the pyrethroid class of insecticides. Since A. funestus is one of the major African malaria vectors, knowledge of its genetic structure will benefit co... | 10.1016/j.actatropica.2003.10.011 | 14,739,021 | D000349:Africa; D000818:Animals; D000852:Anopheles; D004199:Disease Vectors; D014644:Genetic Variation; D005828:Genetics, Population; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic | Acta tropica | 2,004 | |
Intravitreal injection of docosahexaenoic acid attenuated photoreceptor cell injury in a NaIO3-induced age-related macular degeneration rat model. | In most studies, the major supplement docosahexaenoic acid (DHA) is administered orally or intraperitoneally. In this study, we proposed to assess the safety and efficacy of the intravitreal injection of DHA in an age-related macular degeneration (AMD) rat model. Different concentrations of DHA were injected into the v... | 10.1016/j.neulet.2017.07.041 | 28,751,206 | D000818:Animals; D017209:Apoptosis; D004195:Disease Models, Animal; D004281:Docosahexaenoic Acids; D005260:Female; D005911:Gliosis; D007249:Inflammation; D058449:Intravitreal Injections; D007452:Iodates; D008268:Macular Degeneration; D018384:Oxidative Stress; D010786:Photoreceptor Cells; D051381:Rats; D017207:Rats, Spr... | Neuroscience letters | 2,017 | D007452:Iodates; D004281:Docosahexaenoic Acids; C032285:sodium iodate |
Antitumor Response and Immunomodulatory Effects of Sub-Microsecond Irreversible Electroporation and Its Combination with Calcium Electroporation. | In this work, we have investigated the feasibility of sub-microsecond range irreversible electroporation (IRE) with and without calcium electroporation in vivo. As a model, BALB/C mice were used and bioluminescent SP2/0 myeloma tumor models were developed. Tumors were treated with two separate pulsed electric field (PE... | 10.3390/cancers11111763 | 31,717,542 | Cancers | 2,019 | ||
Endoscopic Management of Postoperative Complications. | Gastrointestinal surgery is increasingly being performed. Despite improving technology and outcomes, complications are not completely avoidable. Frequently, surgical complications require invasive procedures for management. However, with increasing availability of flexible endoscopy and a wider array of tools, more oft... | 10.1016/j.suc.2020.08.007 | 33,128,883 | D004066:Digestive System Diseases; D013505:Digestive System Surgical Procedures; D006801:Humans; D011183:Postoperative Complications | The Surgical clinics of North America | 2,020 | |
Rectal cancer with a metastasis to the thyroid gland: A case report. | INTRODUCTION
Metastases to the thyroid gland in patients with colorectal cancer are uncommon. We report a patient with rectal cancer who developed a metastasis to the thyroid gland.
PRESENTATION OF CASE
The patient was a 45-year-old female five years status post rectal cancer resection. A thyroid lesion was detected ... | 10.1016/j.ijscr.2019.11.013 | 31,790,950 | International journal of surgery case reports | 2,020 | ||
Na(+)-dependent transport of aminopeptidase-resistant sugar-coupled tripeptides in rat intestine. | Aminopeptidase-degradable tripeptide, tyrosylglycylglycine (TGG, a part of aminopeptidase-degradable enkephalines), was coupled with sugars (cellobiose, maltose, lactose, gentiobiose and glucose). These sugar-coupled TGGs were stable enough to be transported from the mucosal to the serosal side in rat everted small int... | 10.1006/bbrc.1994.2342 | 7,945,288 | D000595:Amino Acid Sequence; D000818:Animals; D006020:Glycopeptides; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D007408:Intestinal Absorption; D007583:Jejunum; D008297:Male; D008969:Molecular Sequence Data; D009842:Oligopeptides; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium | Biochemical and biophysical research communications | 1,994 | D006020:Glycopeptides; D007202:Indicators and Reagents; D009842:Oligopeptides; C044757:tyrosyl-glycyl-glycine; D012964:Sodium |
Health beliefs of hypertensive patients in a family medicine residency program. | This paper presents the results of a survey of the hypertensive patient population in a university family medicine practice to determine health beliefs, patient perceptions of the severity of their condition, stated levels of compliance to drug regimens, frequency of drug side effects, and frequency of physician discus... | 490,109 | D000328:Adult; D000368:Aged; D001294:Attitude to Health; D005194:Family Practice; D005260:Female; D006801:Humans; D006973:Hypertension; D007396:Internship and Residency; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010817:Physician-Patient Relations | The Journal of family practice | 1,979 | ||
Comparison of immune responses in inbred lines of chickens to Eimeria maxima and Eimeria tenella. | Immune responses of 4 inbred lines of chickens, that differ in resistance to Eimeria maxima and E. tenella, were examined. Significant differences were found in in vitro proliferation of peripheral blood lymphocytes to E. maxima sporozoite antigen, the more resistant lines C and 7(2) having higher responses than the mo... | 10.1017/s003118200006488x | 7,675,528 | D000818:Animals; D000913:Antibodies, Protozoan; D000917:Antibody Formation; D002645:Chickens; D003048:Coccidiosis; D004198:Disease Susceptibility; D004539:Eimeria; D016786:Eimeria tenella; D007113:Immunity, Innate; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D011201:Poultry Diseases; D013045:Species Specif... | Parasitology | 1,995 | D000913:Antibodies, Protozoan |
Two distinct Na+ currents control cytosolic Ca2+ pulsing in Xenopus laevis pituitary melanotrophs. | Studies with the Na+ channel blocker tetrodotoxin (TTx) on Ca(2+)-dependent hormone release by mammalian and amphibian pituitary melanotrophs have suggested that the Na+ spikes these cells generate are not responsible for triggering Ca2+ influx and consequently secretion. In contrast, we found in Xenopus laevis melanot... | 10.1016/s0143-4160(97)90048-8 | 9,105,733 | D000818:Animals; D002104:Cadmium; D002118:Calcium; D002478:Cells, Cultured; D003600:Cytosol; D004594:Electrophysiology; D005071:Evoked Potentials; D005260:Female; D005470:Fluorometry; D008297:Male; D018408:Patch-Clamp Techniques; D010902:Pituitary Gland; D015222:Sodium Channels; D013779:Tetrodotoxin; D014701:Veratridin... | Cell calcium | 1,997 | D015222:Sodium Channels; D002104:Cadmium; D013779:Tetrodotoxin; D014701:Veratridine; D002118:Calcium |
Neuropsychological test performance of Swedish multiple chemical sensitivity patients--an exploratory study. | To address the hypothesis of brain dysfunction as a component of the multiple chemical sensitivity (MCS) syndrome, a neuropsychological battery comprising 8 tests was given to 17 Swedish MCS patients and 34 demographically matched controls. Across the 6 tests used as indicators of brain impairment, comprising a total o... | 10.1207/S15324826AN0903_2 | 12,584,079 | D000328:Adult; D001921:Brain; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018777:Multiple Chemical Sensitivity; D009483:Neuropsychological Tests; D010865:Pilot Projects; D011594:Psychometrics; D012647:Self-Assessment; D013548:Sweden | Applied neuropsychology | 2,002 | |
The ependymal region of the adult human spinal cord differs from other species and shows ependymoma-like features. | Several laboratories have described the existence of undifferentiated precursor cells that may act like stem cells in the ependyma of the rodent spinal cord. However, there are reports showing that this region is occluded and disassembled in humans after the second decade of life, although this has been largely ignored... | 10.1093/brain/awv089 | 25,882,650 | D000328:Adult; D000368:Aged; D000375:Aging; D016022:Case-Control Studies; D004805:Ependyma; D004806:Ependymoma; D005260:Female; D015870:Gene Expression; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013045:Species Specificity; D013115:Spinal Canal; D013116:Spinal Cord; D013119:... | Brain : a journal of neurology | 2,015 | |
Demography and economics of HIV/AIDS. | The rapid spread of HIV in the 1980s and 1990s in the non-industrialised world is now leading to an AIDS epidemic. This in turn is having a demographic and economic impact on these societies. This article assesses the most recent evidence for these impacts. It concludes that, while there is already a real and measurabl... | 10.1093/bmb/58.1.73 | 11,714,625 | D000293:Adolescent; D000328:Adult; D000349:Africa; D002675:Child, Preschool; D003710:Demography; D004196:Disease Outbreaks; D004651:Employment; D005260:Female; D015658:HIV Infections; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012959:Socioeconomic Fac... | British medical bulletin | 2,001 | |
Intrauterine device use and risk of ovarian cancer: Results from the New England Case-Control study and Nurses' Health Studies. | Results of studies assessing intrauterine device (IUD) use and ovarian cancer risk are inconsistent. We examined the association between IUD use, including duration, type and timing of use, and ovarian cancer risk using three population-based studies. Data from the New England Case-Control Study (NEC) and two prospecti... | 10.1002/ijc.33531 | 33,634,849 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007434:Intrauterine Devices; D008875:Middle Aged; D009511:New England; D009726:Nurses; D010051:Ovarian Neoplasms; D011379:Prognosis; D011446:Prospective S... | International journal of cancer | 2,021 | |
Determination of two ternary mixtures containing phenobarbitone by second derivative of the ratio spectrum-zero-crossing and HPLC methods. | A spectrophotometric method is developed for the determination of ternary mixtures with overlapping spectra. The method is based on the use of the second derivative of the ratio spectrum with a zero-crossing technique. The ratio spectrum was obtained by dividing the absorption spectrum of the mixture by that of one of ... | 10.1016/S0014-827X(03)00047-8 | 12,729,832 | D000927:Anticonvulsants; D002851:Chromatography, High Pressure Liquid; D008618:Mephobarbital; D010208:Papaverine; D010634:Phenobarbital; D010672:Phenytoin; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet; D013678:Technology, Pharmaceutical; D013806:Theophy... | Farmaco (Societa chimica italiana : 1989) | 2,003 | D000927:Anticonvulsants; C023721:acefyllin piperazinate; D008618:Mephobarbital; D010672:Phenytoin; D013806:Theophylline; D010208:Papaverine; D010634:Phenobarbital |
Photoreversible multiple additions of hydrogen to a highly unsaturated platinum-rhenium cluster complex. | The compound Pt3Re2(CO)6(PBut3)3, 1, was obtained from the reaction of Re2(CO)10 with Pt(PBut3)2 in octane solvent at reflux. Compound 1 consists of a trigonal bipyramidal cluster of five metal atoms with three platinum atoms in the trigonal plane and the two rhenium atoms in the apical positions. The metal cluster is ... | 10.1021/ja067028g | 17,243,836 | Journal of the American Chemical Society | 2,007 | ||
A potential prodrug for a green tea polyphenol proteasome inhibitor: evaluation of the peracetate ester of (-)-epigallocatechin gallate [(-)-EGCG]. | Green tea has been shown to have many biological effects, including effects on metabolism, angiogenesis, oxidation, and cell proliferation. Unfortunately, the most abundant green tea polyphenol (-)-epigallocatechin gallate or (-)-EGCG is very unstable in neutral or alkaline medium. This instability leads to a low bioav... | 10.1016/j.bmc.2004.08.002 | 15,465,336 | D002392:Catechin; D004353:Drug Evaluation, Preclinical; D004952:Esters; D005419:Flavonoids; D006801:Humans; D019169:Jurkat Cells; D010463:Peracetic Acid; D010636:Phenols; D059808:Polyphenols; D011355:Prodrugs; D011480:Protease Inhibitors; D046988:Proteasome Endopeptidase Complex; D061988:Proteasome Inhibitors; D013662:... | Bioorganic & medicinal chemistry | 2,004 | D004952:Esters; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D011355:Prodrugs; D011480:Protease Inhibitors; D061988:Proteasome Inhibitors; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate; D046988:Proteasome Endopeptidase Complex; D010463:Peracetic Acid |
Surgical management of Binder's syndrome: lessons learned. | Maxillonasal dysplasia, commonly known as Binder's syndrome, is unmistakably characterized by midfacial hypoplasia and a retruded flat nose. The condition is variably expressed, and reconstruction must be tailored to the individual. Controversy still exists over the optimal age for surgery and the ideal treatment strat... | 10.1007/s00266-010-9533-7 | 20,526,595 | D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D006801:Humans; D008437:Maxilla; D019767:Maxillofacial Abnormalities; D009666:Nose; D019919:Prosthesis Implantation; D012225:Rhinoplasty; D016896:Treatment Outcome | Aesthetic plastic surgery | 2,010 | |
Surgical Complexity of Pulmonary Resections Performed for Oligometastatic NSCLC. | INTRODUCTION
Pulmonary resection has been established as an important component of local consolidative therapy (LCT) for oligometastatic NSCLC. However, technical aspects of such surgical procedures have not been well characterized. We sought to review the complexity of operations performed within a large cohort of pat... | 10.1016/j.jtocrr.2022.100288 | 35,252,897 | JTO clinical and research reports | 2,022 | ||
Historical population estimates for Egypt: a critical review. | "This article attempts to piece together historical population estimates for Egypt and to assess their credibility, starting from Pharaonic times and continuing through the Greek and Roman eras and the Middle Ages.... While many doubts are raised concerning several of the estimates, the article suggests that population... | 12,343,672 | D000349:Africa; D000352:Africa, Northern; D003710:Demography; D003906:Developing Countries; D004534:Egypt; D005069:Evaluation Studies as Topic; D008877:Middle East; D011153:Population; D011156:Population Density; D011157:Population Dynamics; D011158:Population Growth; D012106:Research; D013223:Statistics as Topic | Population bulletin of the United Nations | 1,991 | ||
The Patient-Reported Information Multidimensional Exploration (PRIME) Framework for Investigating Emotions and Other Factors of Prostate Cancer Patients with Low Intermediate Risk Based on Online Cancer Support Group Discussions. | BACKGROUND
This study aimed to use the Patient Reported Information Multidimensional Exploration (PRIME) framework, a novel ensemble of machine-learning and deep-learning algorithms, to extract, analyze, and correlate self-reported information from Online Cancer Support Groups (OCSG) by patients (and partners of patien... | 10.1245/s10434-018-6372-2 | 29,468,607 | D000328:Adult; D000367:Age Factors; D000368:Aged; D000465:Algorithms; D000077321:Deep Learning; D004644:Emotions; D006801:Humans; D020407:Internet; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D011471:Prostatic Neoplasms; D011788:Quality of Life; D011878:Radiotherapy; D012307:Risk Factors; D057566:Self Rep... | Annals of surgical oncology | 2,018 | |
A tumor environment responsive doxorubicin-loaded nanoparticle for targeted cancer therapy. | Doxorubicin (DOX) is a potent cancer chemotherapeutic agent, but its clinical use is severely limited by potentially lethal cardiotoxicity. Delivery of DOX by particulate carriers can be an effective way to reduce its distribution in cardiac tissue. In the present study, we developed a self-assembled, tumor-microenviro... | 10.1021/mp4007776 | 24,735,448 | D000818:Animals; D000970:Antineoplastic Agents; D045744:Cell Line, Tumor; D004317:Doxorubicin; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D051379:Mice; D053758:Nanoparticles; D012709:Serum Albumin | Molecular pharmaceutics | 2,014 | D000970:Antineoplastic Agents; D004337:Drug Carriers; D012709:Serum Albumin; D004317:Doxorubicin |
Familial Mediterranean Fever Complicated by a Triad of Adrenal Crisis: Amyloid Goiter and Cardiac Amyloidosis. | BACKGROUND
FMF is a common disease in the Mediterranean populations and may be complicated by AA amyloidosis. The coexistence of adrenal and thyroid amyloidosis in AA amyloidosis secondary to familial Mediterranean fever (FMF) is an extremely rare reported condition. We presented a previously unreported triad of adrena... | 10.1155/2020/7865291 | 32,518,703 | Case reports in rheumatology | 2,020 | ||
Optimal Sales Promotion in a Supply Chain Using Consignment Contract under Stochastic Demand. | Sales promotion is getting more and more prosperous in Chinese cross-border e-commerce platforms where the demand is uncertain. However, most existing literature on promotion strategies is focusing on deterministic demand. In this paper, we propose a game-theoretical model under multiplicative stochastic demand to inve... | 10.1007/s11518-022-5532-x | 35,757,565 | Journal of systems science and systems engineering | 2,022 | ||
Influence of secondary aspiration on human aspiration efficiency. | Computational fluid dynamics (CFD) was used to evaluate the contribution of secondary aspiration to human aspiration efficiency estimates using a humanoid model with realistic facial features. This study applied coefficient of restitution (CoR) values for working-aged human facial skin to the facial regions on the huma... | 10.1016/j.jaerosci.2014.04.008 | 26,778,849 | Journal of aerosol science | 2,014 | ||
IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A. | Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer IRE1α. Filamin A is an actin crosslinking factor involved in cytoskeleton remodelling. We show t... | 10.1038/s41556-018-0141-0 | 30,013,108 | D008841:Actin Cytoskeleton; D000818:Animals; D002465:Cell Movement; D029721:Drosophila Proteins; D004331:Drosophila melanogaster; D004722:Endoribonucleases; D019143:Evolution, Molecular; D005260:Female; D005347:Fibroblasts; D064448:Filamins; D057809:HEK293 Cells; D006801:Humans; D007700:Kinetics; D008297:Male; D051379:... | Nature cell biology | 2,018 | D029721:Drosophila Proteins; C578663:FLNA protein, human; D064448:Filamins; C529499:FlnA protein, mouse; D029961:Zebrafish Proteins; C528229:ERN1 protein, human; C510185:Ern1 protein, mouse; D017346:Protein Serine-Threonine Kinases; D004722:Endoribonucleases |
Fever of unknown origin caused by dental infection. Report of a case. | There are indications that dental infections may be causally related to a wide spectrum of systemic and local disorders. We present a case report of a fever that lasted more than 50 days and discuss the pathogenesis of associated dental infections. | 10.1016/0030-4220(87)90086-7 | 3,476,896 | D003790:Dental Pulp Necrosis; D005335:Fever of Unknown Origin; D005491:Focal Infection, Dental; D006801:Humans; D008297:Male; D008875:Middle Aged; D010485:Periapical Periodontitis | Oral surgery, oral medicine, and oral pathology | 1,987 | |
Interactive effects of Empagliflozin and Hyperglycemia on Urinary Amino Acids in Individuals with Type 1 Diabetes. | Optimizing energy utilization in the kidney is critical for normal kidney function. Here, we investigate the effect of hyperglycemia and sodium-glucose cotransporter-2 (SGLT2) inhibition on urinary amino acid excretion in individuals with type 1 diabetes (T1D). The open-label ATIRMA trial assessed the impact of 8 weeks... | 10.2337/db23-0694 | 38,015,810 | Diabetes | 2,023 | ||
[Medical disciplinary law: drastic review necessary]. | The purpose of medical disciplinary law is to monitor and promote the quality of professional practice. This objective is insufficiently achieved, and the structure of the disciplinary procedure therefore requires drastic improvement. In disciplinary law, the (individual) complainant has been given too much responsibil... | 35,138,727 | D003695:Delivery of Health Care; D006801:Humans; D008318:Malpractice | Nederlands tijdschrift voor geneeskunde | 2,021 |
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