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The ethical sensitivity of nurses in Turkey. | In this study we tried to gain information about the ethical sensitivity (as well as the ethical knowledge) of nurses working at the bedside in our country. Four scenarios were presented to 165 nurses working in hospital wards in Kocaeli. More than half of the nurses can be considered to have made decisions based on be... | 10.1177/096973300100800403 | 16,004,085 | D000328:Adult; D000368:Aged; D003219:Confidentiality; D003657:Decision Making; D004993:Ethics, Nursing; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D024802:Nurse's Role; D011795:Surveys and Questionnaires; D016312:Treatment Refusal; D014342:Truth Disclosure; D014421:Turkey | Nursing ethics | 2,001 | |
Idiopathic intracranial hypertension in child. | We present the case of a 12-year-old boy with bilateral papilledema, relating moderate symptomatology and without an important medical history. Ophthalmological examination revealed a significant alteration of visual acuity, an important papilledema and macular edema in both eyes. Further investigations excluded infect... | 10.22336/rjo.2020.66 | 33,367,182 | D002257:Carbonic Anhydrase Inhibitors; D002648:Child; D006801:Humans; D008297:Male; D009898:Optic Disk; D010211:Papilledema; D011559:Pseudotumor Cerebri; D041623:Tomography, Optical Coherence; D014792:Visual Acuity | Romanian journal of ophthalmology | 2,020 | D002257:Carbonic Anhydrase Inhibitors |
Task-dependent force sharing between muscle synergists during locomotion in turkeys. | At most joints, there is a redundancy of muscle function. For any given movement, there are a wide range of possible solutions to the problem of how force is shared among muscle synergists. A better understanding of how force is shared among muscle synergists can provide insight into the mechanics and control of moveme... | 10.1242/jeb.013227 | 18,375,845 | D000818:Animals; D007596:Joints; D008124:Locomotion; D018482:Muscle, Skeletal; D013643:Tarsus, Animal; D014422:Turkeys; D016474:Weight-Bearing | The Journal of experimental biology | 2,008 | |
Effects of neuraminidase on O2 consumption and release of O2 and H2O2 from phagocytosing human polymorphonuclear leukocytes. | Neuraminidase type X (NMD-type-X, Sigma Chemical Co., St. Louis, Mo.), which is obtained from a further purification of neuraminidase type V (NMD-type-V, Sigma), markedly enhanced the release of O2- and H2O2 from phagocytosing human polymorphonuclear leukocytes (PMN). In contrast, O2 consumption by NMD-type-X-treated P... | 7,093,528 | D002474:Cell-Free System; D006801:Humans; D006861:Hydrogen Peroxide; D009439:Neuraminidase; D009504:Neutrophils; D010101:Oxygen Consumption; D010587:Phagocytosis; D012794:Sialic Acids | Blood | 1,982 | D012794:Sialic Acids; D006861:Hydrogen Peroxide; D009439:Neuraminidase | |
A field evaluation of anthelmintics in horses in Sweden. | A field evaluation of anthelmintics in 336 horses on 37 farms was conducted between February and May 1986 in Sweden. The herds, each comprising at least eight horses, had histories of grazing on permanent pastures and receiving regular treatments against parasites at least three times a year. Small strongyles were refr... | 10.1016/0304-4017(89)90117-9 | 2,773,268 | D000818:Animals; D000871:Anthelmintics; D004341:Drug Evaluation; D005243:Feces; D006736:Horses; D010270:Parasite Egg Count; D013319:Strongyle Infections, Equine; D013548:Sweden | Veterinary parasitology | 1,989 | D000871:Anthelmintics |
Investigating the Streptococcus sinensis competence regulon through a combination of transcriptome analysis and phenotypic evaluation. | Streptococcus sinensis is a recently identified member of the Mitis group of streptococci. This species has been associated with infective endocarditis; however its mechanisms of pathogenesis and virulence are not fully understood. This study aimed to investigate the influence of the competence-stimulating peptide (CSP... | 10.1099/mic.0.001256 | 36,282,148 | D018085:Regulon; D001426:Bacterial Proteins; D053038:Quorum Sensing; D020869:Gene Expression Profiling; D010641:Phenotype; D012333:RNA, Messenger; D015964:Gene Expression Regulation, Bacterial | Microbiology (Reading, England) | 2,022 | D001426:Bacterial Proteins; D012333:RNA, Messenger |
Ultrafast optical kerr effect in liquids and solids. | In the optical Kerr effect, the electric field of light incident on a transparent sample induces an anisotropic refractive index, which is measured by its effect on the passage of a second light beam. The advent of lasers powerful enough to generate a measurable effect, and which can be pulsed on femtosecond time scale... | 10.1126/science.262.5138.1386 | 17,736,818 | Science (New York, N.Y.) | 1,993 | ||
Evaluation of mutual interference between bovine α-lactalbumin peptide and its isotope-labeled peptide in whey protein analysis using liquid chromatography-tandem mass spectrometry. | Internal standard (IS) method is commonly used to correct the matrix effect of samples in the liquid chromatography-tandem mass spectrometric (LC-MS/MS) analysis of whey proteins. However, the presence of mutual interference between some peptides and their isotope-labeled peptides distorts the MS signals, requiring a f... | 10.1016/j.chroma.2017.12.024 | 29,246,421 | D000818:Animals; D002417:Cattle; D002853:Chromatography, Liquid; D005504:Food Analysis; D006801:Humans; D007223:Infant; D041943:Infant Formula; D007553:Isotope Labeling; D007768:Lactalbumin; D007782:Lactoglobulins; D010455:Peptides; D011208:Powders; D053719:Tandem Mass Spectrometry; D000067816:Whey Proteins | Journal of chromatography. A | 2,018 | D007782:Lactoglobulins; D010455:Peptides; D011208:Powders; D000067816:Whey Proteins; D007768:Lactalbumin |
Increase of plasma adrenocorticotrophin and cortisol in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated dogs. | Neuroendocrine abnormality of the hypothalamic-pituitary-adrenal axis was investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated dogs as a model of Parkinson's disease. Blood samples were collected every 4 h for 3-4 days before MPTP treatment, around 2 and 4 weeks after the treatment of MPTP (2.5 m... | 10.1016/0006-8993(93)91678-l | 8,101,134 | D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000311:Adrenal Glands; D000324:Adrenocorticotropic Hormone; D000818:Animals; D002940:Circadian Rhythm; D004285:Dogs; D015259:Dopamine Agents; D006854:Hydrocortisone; D007031:Hypothalamus; D008297:Male; D009994:Osmolar Concentration; D010302:Parkinson Disease, Secon... | Brain research | 1,993 | D015259:Dopamine Agents; C048977:1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine; D000324:Adrenocorticotropic Hormone; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D006854:Hydrocortisone |
Children's understanding of their emotionally disturbed peers. I. The concept of emotional disturbance. | Study of the interpersonal relations of emotionally disturbed children has focused largely on relationships within the family. Theories of childhood psychopathology focus almost exclusively on the parent-child triad as the etiological core of childhood emotional disturbance (Frank, 1965). Far less attention has been pa... | 940,897 | D000342:Affective Symptoms; D000987:Antisocial Personality Disorder; D002648:Child; D004522:Educational Status; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D010324:Passive-Aggressive Personality Disorder; D010379:Peer Group; D010698:Phobic Disorders; D011618:Psychotic Disorders; D0127... | Psychiatry | 1,976 | ||
The effect of hyperbaric oxygen treatment on early regeneration of sensory axons after nerve crush in the rat. | Abstract The effect of hyperbaric oxygen treatment (HBO) on sensory axon regeneration was examined in the rat. The sciatic nerve was crushed in both legs. In addition, the distal stump of the sural nerve on one side was made acellular and its blood perfusion was compromised by freezing and thawing. Two experimental gro... | 10.1046/j.1529-8027.2002.02020.x | 12,365,561 | D000818:Animals; D001369:Axons; D006931:Hyperbaric Oxygenation; D008297:Male; D009409:Nerve Crush; D009416:Nerve Regeneration; D009475:Neurons, Afferent; D051381:Rats; D017208:Rats, Wistar; D020426:Sciatic Neuropathy | Journal of the peripheral nervous system : JPNS | 2,002 | |
Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria. | Mycobacterial phosphatidylinositol mannosides (PIMs) and metabolically derived cell wall lipoglycans play important roles in host-pathogen interactions, but their biosynthetic pathways are poorly understood. Here we focus on Mycobacterium smegmatis PimA, an essential enzyme responsible for the initial mannosylation of ... | 10.1074/jbc.M702087200 | 17,510,062 | D001426:Bacterial Proteins; D002384:Catalysis; D008364:Mannosyltransferases; D008565:Membrane Proteins; D008958:Models, Molecular; D016296:Mutagenesis; D020102:Mycobacterium smegmatis; D010716:Phosphatidylinositols; D017434:Protein Structure, Tertiary | The Journal of biological chemistry | 2,007 | D001426:Bacterial Proteins; D008565:Membrane Proteins; D010716:Phosphatidylinositols; C093299:GDP-mannosyltransferase; D008364:Mannosyltransferases |
Short communication: RNA interference directed against Axin1 upregulates human immunodeficiency virus type 1 gene expression by activating the Wnt signaling pathway in HeLa-derived J111 cells. | Axin1, a regulator of Wnt signaling, was previously identified as playing a negative role in the late phase of human immunodeficiency virus type 1 (HIV-1) replication in HeLa-derived J111 cells. In this report, we studied the molecular mechanism of how Axin1 regulates HIV-1 replication. HIV-1 transactivator, Tat-depend... | 10.1089/aid.2008.0284 | 19,778,269 | D060466:Axin Protein; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D015967:Gene Expression Regulation, Viral; D015497:HIV-1; D006367:HeLa Cells; D006801:Humans; D034622:RNA Interference; D012097:Repressor Proteins; D015398:Signal Transduction; D000073940:Transcription Factor 4; D014157:Transcrip... | AIDS research and human retroviruses | 2,009 | C555451:AXIN1 protein, human; D060466:Axin Protein; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D012097:Repressor Proteins; C532096:TCF4 protein, human; D000073940:Transcription Factor 4; D014157:Transcription Factors; D051176:beta Catenin; D054322:tat Gene Products, Human Immunodeficiency Viru... |
DNA image cytometry and fluorescence in situ hybridization for noninvasive detection of urothelial tumors in voided urine. | BACKGROUND
Cystoscopy and histologic examination remain the standard methods for initial tumor diagnosis and monitoring for early detection of recurrences, since the sensitivity of conventional urinary cytology for the detection of urothelial tumors in urinary specimens is low. DNA image cytometry (ICM) and fluorescenc... | 10.1002/cncr.10881 | 12,478,686 | D002295:Carcinoma, Transitional Cell; D004273:DNA, Neoplasm; D006801:Humans; D019044:Image Cytometry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D011003:Ploidies; D011470:Prostatic Hyperplasia; D001749:Urinary Bladder Neoplasms | Cancer | 2,002 | D004273:DNA, Neoplasm |
Suicide in Old Norse and Finnish folk stories. | OBJECTIVE
The aim of this study was to examine the folk stories of Norway, Iceland and Finland with a view to discovering accounts of suicide as an escape option from intolerable predicaments, and to compare any such accounts with material from Southern Europe.
METHOD
The Poetic Edda (Norway/Iceland) and The Kalevala... | 10.3109/10398562.2011.603331 | 21,879,867 | D003469:Culture; D005387:Finland; D009229:Mythology; D011037:Poetry as Topic; D012537:Scandinavian and Nordic Countries; D013405:Suicide | Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists | 2,011 | |
Different patterns of left ventricular enlargement and long-term prognosis after reperfused acute myocardial infarction. | BACKGROUND
Dilation of end-systolic and end-diastolic volumes (ESV, EDV) has been used to define left ventricular remodelling after acute myocardial infarction (MI), but the prognostic significance of different enlargement patterns has not been evaluated fully.
AIM
To analyse the evolution of left ventricular volumes... | 10.1016/j.acvd.2009.04.012 | 19,786,263 | D000328:Adult; D000368:Aged; D017130:Angioplasty; D018572:Disease-Free Survival; D005260:Female; D006352:Heart Ventricles; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction; D011446:Prospective Studies; D013318:Stroke Volume; ... | Archives of cardiovascular diseases | 2,009 | |
Nicotinamide Augments the Anti-Inflammatory Properties of Resveratrol through PARP1 Activation. | Resveratrol (RSV) and nicotinamide (NAM) have garnered considerable attention due to their anti-inflammatory and anti-aging properties. NAM is a transient inhibitor of class III histone deacetylase SIRTs (silent mating type information regulation 2 homologs) and SIRT1 is an inhibitor of poly-ADP-ribose polymerase-1 (PA... | 10.1038/s41598-019-46678-8 | 31,308,445 | D000893:Anti-Inflammatory Agents; D018929:Cell Culture Techniques; D051546:Cyclooxygenase 2; D006801:Humans; D009000:Monocytes; D009536:Niacinamide; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases; D051560:Proto-Oncogene Proteins c-bcl-6; D000077185:Resveratrol; D015398:Signal Transducti... | Scientific reports | 2,019 | D000893:Anti-Inflammatory Agents; C084103:BCL6 protein, human; D051560:Proto-Oncogene Proteins c-bcl-6; D009536:Niacinamide; D051546:Cyclooxygenase 2; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases; D056564:Sirtuin 1; D037761:Sirtuins; D000077185:Resveratrol |
Support for bereaved owners of pets. | TOPIC
The bond that exists between people and their pets and its impact on physical and mental health.
PURPOSE
To review the current literature and explore the clinical implications of bereavement related to pets.
SOURCES
A comprehensive review of the bereavement, veterinarian, and agricultural literature related t... | 10.1111/j.1744-6163.2003.tb00676.x | 12,894,598 | D000223:Adaptation, Psychological; D000328:Adult; D000818:Animals; D000829:Animals, Domestic; D001293:Attitude to Death; D001601:Bereavement; D003643:Death; D005655:Funeral Rites; D006293:Health Promotion; D001841:Human-Animal Bond; D006801:Humans; D008016:Life Change Events; D008297:Male; D008603:Mental Health; D01035... | Perspectives in psychiatric care | 2,003 | |
Genetic variations of the Plasmodium vivax dihydropteroate synthase gene. | Dihydropteroate synthase gene of Plasmodium vivax was recently identified. In the present study, the sequences of the dyhydropteroate synthase gene of 68 P. vivax isolates from various geographic areas were compared. Sequencing revealed limited polymorphism at codons 383 and 553 in all analyzed samples. Interstrain ana... | 10.1016/j.actatropica.2006.03.003 | 16,647,679 | D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D016054:DNA, Protozoan; D004094:Dihydropteroate Synthase; D004351:Drug Resistance; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D016780:Malaria, Vivax; D008969:Molecular Sequence Data; D010966:Plasmodium vivax; D016133:Polymerase Chain... | Acta tropica | 2,006 | D016054:DNA, Protozoan; D004094:Dihydropteroate Synthase |
Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29. | Collagen fibrillogenesis and crosslinking have long been implicated in extracellular matrix (ECM)-dependent processes such as fibrosis and scarring. However, the extent to which matricellular proteins influence ECM protein production and fibrillar collagen crosslinking has yet to be determined. Here we show that thromb... | 10.1016/j.matbio.2019.03.002 | 30,876,926 | D000818:Animals; D003094:Collagen; D015536:Down-Regulation; D005109:Extracellular Matrix; D016326:Extracellular Matrix Proteins; D055786:Gene Knockout Techniques; D008297:Male; D051379:Mice; D035683:MicroRNAs; D008249:Protein-Lysine 6-Oxidase; D040901:Proteomics; D019699:Thrombospondins | Matrix biology : journal of the International Society for Matrix Biology | 2,019 | D016326:Extracellular Matrix Proteins; C547014:MIRN29 microRNA, mouse; D035683:MicroRNAs; D019699:Thrombospondins; C101862:thrombospondin 2; C077112:Lox protein, mouse; D003094:Collagen; D008249:Protein-Lysine 6-Oxidase |
Assessing the role of SWIR band in detecting agricultural crop stress: a case study of Raichur district, Karnataka, India. | The potential consequence of global climatic change caused the rise in temperature and precipitation decline, the aftermath of which has led to phenomenon like drought. As the agriculture is mainly dependent on the timely availability of water, delayed arrival of rainfall or decrease in the intensity of precipitation h... | 10.1007/s10661-019-7566-1 | 31,203,445 | D057231:Climate Change; D018556:Crops, Agricultural; D055864:Droughts; D004784:Environmental Monitoring; D007194:India; D011846:Radio Waves; D058998:Remote Sensing Technology; D012621:Seasons; D012987:Soil; D013696:Temperature; D014867:Water | Environmental monitoring and assessment | 2,019 | D012987:Soil; D014867:Water |
Waveform dynamics of spermatozeugmata during the transfer from paternal to maternal individuals of Membranipora membranacea. | Analysis of standard (60 frames/s) and high-speed (200 frames/s) video records revealed that unencapsulated sperm aggregates (spermatozeugmata) of the gymnolaemate bryozoan Membranipora membranacea spontaneously generate at least three types of waveforms: small amplitude, large amplitude, and reverse. All three wavefor... | 10.2307/1543196 | 14,977,728 | D000818:Animals; D001696:Biomechanical Phenomena; D002013:Bryozoa; D008297:Male; D009068:Movement; D009991:Oscillometry; D012098:Reproduction; D013081:Sperm Motility; D013094:Spermatozoa; D014741:Video Recording | The Biological bulletin | 2,004 | |
How Postdoctoral Research in Paul Greengard's Laboratory Shaped My Scientific Career, Although I Never Did Another Phosphorylation Assay. | In this short review, I describe from personal experience how every step in the career of any scientist, no matter how disjointed and pragmatic each might seem at the time, will almost inevitably meld together, to help us all tackle novel projects. My postdoctoral research in Paul Greengard's laboratory, where I invest... | 10.1523/JNEUROSCI.3002-20.2021 | 33,558,431 | D002321:Career Choice; D006801:Humans; D018377:Neurotransmitter Agents; D010766:Phosphorylation; D016704:Synapsins | The Journal of neuroscience : the official journal of the Society for Neuroscience | 2,021 | D018377:Neurotransmitter Agents; D016704:Synapsins |
Influence of Stabilization Techniques Used in the Treatment of Low Back Pain on the Level of Kinesiophobia. | The aim of this study was to try to compare the effectiveness of manual therapy techniques in combination with stabilization techniques: the so-called Australian method and the Neurac method in relation to pain sensations and the level of kinesiophobia. A total of 69 people were examined, divided into three groups of 2... | 10.3390/ijerph18126393 | 34,199,155 | D001315:Australia; D004185:Disability Evaluation; D005239:Fear; D006801:Humans; D017116:Low Back Pain; D010147:Pain Measurement | International journal of environmental research and public health | 2,021 | |
[Efforts toward Patient Safety: Development of System and Education of Non-Technical Skill]. | Advanced radiotherapy such as intensity-modulated radiotherapy offers many advantages of high accuracy and efficiency of radiotherapy. To date, many technical guidelines with description of quality assurance and quality control have been reported. However, some reports indicated that human factor and environment is maj... | 10.11323/jjmp.38.2_62 | 30,381,714 | D006801:Humans; D061214:Patient Safety; D011786:Quality Control; D050397:Radiotherapy, Intensity-Modulated; D018570:Risk Assessment; D012308:Risk Management | Igaku butsuri : Nihon Igaku Butsuri Gakkai kikanshi = Japanese journal of medical physics : an official journal of Japan Society of Medical Physics | 2,018 | |
Environmental quality and output volatility: the case of South Asian economies. | This study explores the impact of environmental degradation on output volatility for eight South Asian economies over the time span 1971-2017. Environmental degradation is measured by CO2 emissions, nitrous oxide (N2O), methane emissions (CH4), greenhouse gas emissions (GHG), and environmental pollutants index (EPI), w... | 10.1007/s11356-021-12659-6 | 33,604,832 | D002245:Carbon Dioxide; D003430:Cross-Sectional Studies; D057217:Economic Development; D000074382:Greenhouse Gases; D009609:Nitrous Oxide | Environmental science and pollution research international | 2,021 | D000074382:Greenhouse Gases; D002245:Carbon Dioxide; D009609:Nitrous Oxide |
Multinational Prospective Cohort Study of Mortality Risk Factors in 198 ICUs of 12 Latin American Countries over 24 Years: The Effects of Healthcare-Associated Infections. | BACKGROUND
The International Nosocomial Infection Control Consortium (INICC) has found a high ICU mortality rate in Latin America.
METHODS
A prospective cohort study in 198 ICUs of 96 hospitals in 46 cities in 12 Latin American countries to identify mortality risk factors (RF), and data were analyzed using multiple l... | 10.1007/s44197-022-00069-x | 36,197,596 | D000328:Adult; D006801:Humans; D055499:Catheter-Related Infections; D007843:Latin America; D011446:Prospective Studies; D003428:Cross Infection; D007362:Intensive Care Units; D014552:Urinary Tract Infections; D012307:Risk Factors; D003695:Delivery of Health Care | Journal of epidemiology and global health | 2,022 | |
Detection of hepatitis C virus by a user-developed reverse transcriptase-PCR and use of amplification products for subsequent genotyping. | BACKGROUND
Detection, quantitation and genotyping of hepatitis C virus (HCV) are important in selecting appropriate therapy. Current commercially available HCV genotyping kits, including sequencing-based TRUGENE HCV 5'NC and hybridization-based INNO-LiPA HCV II assays, rely on amplification products (amplicons) generat... | 10.1016/j.jcv.2004.02.010 | 15,364,272 | D001483:Base Sequence; D004279:DNA, Viral; D005838:Genotype; D016174:Hepacivirus; D006526:Hepatitis C; D006801:Humans; D021141:Nucleic Acid Amplification Techniques; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014773:Virology | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology | 2,004 | D004279:DNA, Viral |
Reversible AIE-active fluorescent probe with a large emission peak shift for ratiometric detection of food freshness indicator H2S. | It is crucial to on-site monitor H2S for addressing the concerns associated with food safety. We rationally prepared an AIE-active fluorescent probe (CLBZ) with the aggregated state conversion for sensing H2S in a ratiometric response manner. CLBZ displayed ratiometric response, fast response time (5 s), well-resolved ... | 10.1016/j.foodchem.2022.132768 | 35,349,897 | D005456:Fluorescent Dyes; D006862:Hydrogen Sulfide | Food chemistry | 2,022 | D005456:Fluorescent Dyes; D006862:Hydrogen Sulfide |
Formation Conditions and Sedimentary Characteristics of a Triassic Shallow Water Braided Delta in the Yanchang Formation, Southwest Ordos Basin, China. | A large, shallow braided river delta sedimentary system developed in the Yanchang Formation during the Triassic in the southwest of the Ordos basin. In this braided delta system, abundant oil and gas resources have been observed, and the area is a hotspot for oil and gas resource exploration. Through extensive field wo... | 10.1371/journal.pone.0119704 | 26,075,611 | D002681:China; D004784:Environmental Monitoring; D019015:Geologic Sediments; D045483:Rivers; D014867:Water | PloS one | 2,015 | D014867:Water |
Proliferation of bovine undifferentiated mammary epithelial cells in vitro is modulated by G-proteins. | Several cAMP-elevating agents such as cholera toxin (CT), forskolin and 3-isobutyl-1-methylxanthine (IBMX) exhibited weak mitogenic activity on bovine undifferentiated mammary epithelial cells in three-dimensional collagen culture. CT and IBMX strongly synergized with epidermal growth factor (EGF), insulin-like growth ... | 10.1016/0303-7207(90)90015-z | 1,691,721 | D015056:1-Methyl-3-isobutylxanthine; D015124:8-Bromo Cyclic Adenosine Monophosphate; D000246:Adenosine Diphosphate Ribose; D037361:Adenylate Cyclase Toxin; D000818:Animals; D001769:Blood; D002417:Cattle; D002455:Cell Division; D002772:Cholera Toxin; D005576:Colforsin; D000242:Cyclic AMP; D004247:DNA; D004357:Drug Syner... | Molecular and cellular endocrinology | 1,990 | D037361:Adenylate Cyclase Toxin; D007328:Insulin; D010566:Virulence Factors, Bordetella; D005576:Colforsin; D000246:Adenosine Diphosphate Ribose; D015124:8-Bromo Cyclic Adenosine Monophosphate; D004815:Epidermal Growth Factor; D007334:Insulin-Like Growth Factor I; D004247:DNA; D002772:Cholera Toxin; D000242:Cyclic AMP;... |
Pilocarpine treatment of salivary gland hypofunction and dry mouth (xerostomia). | We studied the effects of pilocarpine hydrochloride, a para-sympathomimetic agent, on major salivary gland output and subjective responses in 31 patients with salivary hypofunction. Pilocarpine hydrochloride (5-mg capsules, three times daily) was given for 5 months and a placebo was randomly assigned for 1 month in a d... | 2,043,017 | D000293:Adolescent; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010306:Parotid Gland; D010862:Pilocarpine; D012472:Salivation; D013363:Submandibular Gland; D0149... | Archives of internal medicine | 1,991 | D010862:Pilocarpine | |
Synthesis of a model for C7-C13 of lankamycin. | [structure: see text] A convenient method is reported for construction of the C7-C13 segment of the macrolide antiobiotic lankamycin. | 10.1021/ol990376l | 10,814,237 | D000900:Anti-Bacterial Agents; D004917:Erythromycin; D015394:Molecular Structure; D013302:Streptomyces | Organic letters | 2,000 | D000900:Anti-Bacterial Agents; D004917:Erythromycin; C100149:kujimycin B |
Mapping the antagonist binding site of the serotonin type 3 receptor by fluorescence resonance energy transfer. | We have measured fluorescence resonance energy transfer (FRET) between a fluorescent antagonist, bound to the purified detergent-solubilized serotonin type 3 receptor, and a lipophilic acceptor probe partitioned into the micelle surrounding the detergent-solubilized receptor. The experimentally observed FRET efficiency... | 10.1021/bi0106989 | 11,591,142 | D000818:Animals; D001665:Binding Sites; D003902:Detergents; D008823:Micelles; D008958:Models, Molecular; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; D012995:Solubility; D013050:Spectrometry, Fluorescence | Biochemistry | 2,001 | D003902:Detergents; D008823:Micelles; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3 |
Plasma insulin response to various secretagogues in insulinoma. | Since the development of radioimmunoassay for insulin, the diagnosis of insulinoma has been made easily. However, it has been assumed that insulinoma is heterogenous in the histological structure as well as in clinical findings. Therefore, the present study was performed to investigate the insulin response to various s... | 10.1620/tjem.136.447 | 6,285,549 | D007516:Adenoma, Islet Cell; D000328:Adult; D000368:Aged; D001120:Arginine; D001786:Blood Glucose; D002648:Child; D005215:Fasting; D005260:Female; D005934:Glucagon; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin; D007340:Insulinoma; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms; D0118... | The Tohoku journal of experimental medicine | 1,982 | D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D001120:Arginine; D014044:Tolbutamide |
Effect of transglutaminase 2 (TG2) deficiency on atherosclerotic plaque stability in the apolipoprotein E deficient mouse. | BACKGROUND
Transglutaminase 2 (TG2), a cross-linking enzyme that confers supra-molecular structures with extra rigidity and resistance against proteolytic degradation, is expressed in the shoulder regions of human atherosclerotic plaques. It has been proposed that TG2 prevents tearing and promotes plaque repair at thes... | 10.1016/j.atherosclerosis.2009.11.014 | 20,003,977 | D000818:Animals; D001057:Apolipoproteins E; D001158:Arteries; D050197:Atherosclerosis; D002114:Calcinosis; D005260:Female; D019204:GTP-Binding Proteins; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases | Atherosclerosis | 2,010 | D001057:Apolipoproteins E; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins |
Deriving childhood temperament measures from emotion-eliciting behavioral episodes: scale construction and initial validation. | The authors describe the development and initial validation of a home-based version of the Laboratory Temperament Assessment Battery (Lab-TAB), which was designed to assess childhood temperament with a comprehensive series of emotion-eliciting behavioral episodes. This article provides researchers with general guidelin... | 10.1037/a0021746 | 21,480,723 | D002652:Child Behavior; D002675:Child, Preschool; D004644:Emotions; D005260:Female; D006801:Humans; D008297:Male; D010552:Personality Assessment; D010555:Personality Inventory; D002666:Psychology, Child; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D013694:Temperament | Psychological assessment | 2,011 | |
Electrochemical performance of 2D polyaniline anchored CuS/Graphene nano-active composite as anode material for lithium-ion battery. | Lithium-ion battery (LIB) is a revolutionary step in the electric energy storage technology for making green environment. In the present communication, a LIB anode material was constructed by using graphene/polyaniline/CuS nanocomposite (GR/PANI/CuS NC) as a high-performance electrode. Initially, pure covellite CuS nan... | 10.1016/j.jcis.2017.04.082 | 28,475,938 | Journal of colloid and interface science | 2,017 | ||
Oxygen evolution at functionalized carbon surfaces: a strategy for immobilization of molecular water oxidation catalysts. | A molecular Ru(II) water oxidation catalyst was immobilized on a conductive carbon surface through a covalent bond, and its activity was maintained at the same time. The method can be applied to other materials and may inspire development of artificial photosynthesis devices. | 10.1039/c2cc35379b | 22,945,420 | D002244:Carbon; D002384:Catalysis; D010084:Oxidation-Reduction; D010100:Oxygen; D012428:Ruthenium; D013499:Surface Properties; D014867:Water | Chemical communications (Cambridge, England) | 2,012 | D014867:Water; D002244:Carbon; D012428:Ruthenium; D010100:Oxygen |
Brief Report: Body Image in Autism: Evidence from Body Size Estimation. | Individuals with autism spectrum disorder (ASD) have difficulties with social interaction and communication. First-hand accounts written by individuals with ASD have shown the existence of other atypical characteristics such as difficulties with body awareness. However, few studies have examined whether such atypicalit... | 10.1007/s10803-017-3323-x | 29,038,931 | D000293:Adolescent; D000067877:Autism Spectrum Disorder; D001321:Autistic Disorder; D001828:Body Image; D049628:Body Size; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D012649:Self Concept; D055815:Young Adult | Journal of autism and developmental disorders | 2,018 | |
A simple strategy for the visual detection and discrimination of Hg2+ and CH3Hg+ species using fluorescent nanoaggregates. | Fluorescent nanoaggregates (FNAs) based on phenanthroline-based amphiphiles show changes in solution color from colorless to yellow upon addition of both Hg2+ (LOD ∼4 ppb) and CH3Hg+ (LOD ∼18 ppb). However, the extent of fluorescence quenching is more prominent with Hg2+ (∼12 fold) than with CH3Hg+ (∼4 fold). Also, unl... | 10.1039/d1dt01455b | 34,137,406 | Dalton transactions (Cambridge, England : 2003) | 2,021 | ||
Impact of sulfamethoxazole on a riverine microbiome. | The continued emergence of bacterial pathogens presenting antimicrobial resistance is widely recognised as a global health threat and recent attention focused on potential environmental reservoirs of antibiotic resistance genes (ARGs). Freshwater environments such as rivers represent a potential hotspot for ARGs and an... | 10.1016/j.watres.2021.117382 | 34,225,233 | D000900:Anti-Bacterial Agents; D004352:Drug Resistance, Microbial; D005798:Genes, Bacterial; D064307:Microbiota; D045483:Rivers; D013420:Sulfamethoxazole; D062065:Wastewater | Water research | 2,021 | D000900:Anti-Bacterial Agents; D062065:Waste Water; D013420:Sulfamethoxazole |
[Combining indirect hemagglutination with the direct agglutination as a parameter for evaluating patients sent for serological verification of toxoplasmosis]. | The importance that Toxoplasma gondii congenital infection may assume is still representing a stimulus for trying to improve Toxoplasmosis serological diagnosis; task, this one, which Laboratory is charged with, and that is often hard, particularly when we have to value the possibility of an infection in progress. With... | 2,490,399 | D000328:Adult; D000372:Agglutination Tests; D000913:Antibodies, Protozoan; D005069:Evaluation Studies as Topic; D005260:Female; D006386:Hemagglutination Tests; D006801:Humans; D007075:Immunoglobulin M; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011247:Pregnancy; D011251:Pregnancy Complicatio... | Giornale di batteriologia, virologia ed immunologia | 1,989 | D000913:Antibodies, Protozoan; D007075:Immunoglobulin M | |
Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice. | T cell receptor (TCR) signaling is essential in the development and differentiation of T cells in the thymus and periphery, respectively. The vast array of TCRs proves studying a specific antigenic response difficult. Therefore, TCR transgenic mice were made to study positive and negative selection in the thymus as wel... | 10.3791/54196 | 27,500,835 | D000818:Animals; D001853:Bone Marrow; D051379:Mice; D008822:Mice, Transgenic; D011948:Receptors, Antigen, T-Cell; D012190:Retroviridae; D013234:Stem Cells; D013601:T-Lymphocytes; D013950:Thymus Gland; D014161:Transduction, Genetic | Journal of visualized experiments : JoVE | 2,016 | D011948:Receptors, Antigen, T-Cell |
Alterations in dry mass content of collagen fibers in degenerative tendinopathy and tendon-rupture. | The dry mass concentration and collagen fiber morphology of intact, as well as of degenerated and ruptured human Achilles, biceps brachii, extensor pollicis longus and quadriceps tendons, were determined by using the interference microscopical technique. The variation in the collagen fiber thickness was demonstrated in... | 10.1016/s0934-8832(89)80032-0 | 2,725,420 | D003094:Collagen; D006801:Humans; D009135:Muscular Diseases; D012422:Rupture, Spontaneous; D013710:Tendons | Matrix (Stuttgart, Germany) | 1,989 | D003094:Collagen |
The importance of cnidarian synapses for neurobiology. | Despite being the most primitive organisms to possess a nervous system, cnidarians afford rare opportunities for studying various, general aspects of chemical synaptic transmission. This is made possible by the unique organization of their nervous systems and by the fact that in certain species the neurons and synapses... | 10.1002/neu.480200513 | 2,568,389 | D000818:Animals; D003063:Cnidaria; D037401:Scyphozoa; D013569:Synapses | Journal of neurobiology | 1,989 | |
Scanning and transmission electron microscopic study of Escherichia coli O15 (RDEC-1) enteric infection in rabbits. | RDEC-1 is a piliated strain of Escherichia coli that was isolated from and produces diarrhea in rabbits without invading the mucosa or synthesizing one of the classical enterotoxins. Previous histological and fluorescent-antibody studies of RDEC-1 diarrhea revealed an acute inflammatory response and large numbers of RD... | 10.1128/iai.19.2.686-694.1978 | 344,219 | D000818:Animals; D002462:Cell Membrane; D003967:Diarrhea; D004848:Epithelium; D004926:Escherichia coli; D004927:Escherichia coli Infections; D007413:Intestinal Mucosa; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D011817:Rabbits | Infection and immunity | 1,978 | |
[Heparin-induced thrombocytopenia occurring after surgical treatment of atrial myxoma--a case report]. | INTRODUCTION
Heparin-induced thrombocytopenia (HIT) is an acquired, prothrombotic disorder, caused by antibodies to a complex of heparin and platelet factor 4 (PF4) that activates platelets, resulting in the release of procoagulant microparticles, thrombocytopenia occurrence, generation of thrombin, and frequent thromb... | 10.2298/sarh0910540d | 19,950,764 | D000368:Aged; D000925:Anticoagulants; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D003937:Diagnosis, Differential; D005260:Female; D006325:Heart Atria; D006338:Heart Neoplasms; D006493:Heparin; D006497:Heparitin Sulfate; D006801:Humans; D009232:Myxoma; D011183:Postoperative Complications; D013921:Thrombocyt... | Srpski arhiv za celokupno lekarstvo | 2,009 | D000925:Anticoagulants; D003871:Dermatan Sulfate; D006493:Heparin; D002809:Chondroitin Sulfates; D006497:Heparitin Sulfate; C035838:danaparoid |
Altered expression and localization of N-myristoyltransferase in experimentally induced rat model of ischemia-reperfusion. | N-myristoyltransferase (NMT) catalyzes the attachment of myristate onto the amino-terminal glycine residue of select polypeptides. In the present study, we investigated the expression and activity of NMT in rat heart after ischemia and reperfusion. Western blot analysis of rat heart samples indicated a prominent immuno... | 10.1002/jcb.10248 | 12,210,757 | D000217:Acyltransferases; D000818:Animals; D000906:Antibodies; D015153:Blotting, Western; D004195:Disease Models, Animal; D006801:Humans; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D008297:Male; D015428:Myocardial Reperfusion Injury; D009206:Myocardium; D051381:Rats; D017207:Rats, Sprague-Dawley; D01399... | Journal of cellular biochemistry | 2,002 | D000906:Antibodies; D000217:Acyltransferases; C050480:glycylpeptide N-tetradecanoyltransferase |
Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics. | I hypothesize here that the ability of probiotics to synthesize neuroactive compounds provides a unifying microbial endocrinology-based mechanism to explain the hitherto incompletely understood action of commensal microbiota that affect the host's gastrointestinal and psychological health. Once ingested, probiotics ent... | 10.1002/bies.201100024 | 21,732,396 | D000893:Anti-Inflammatory Agents; D001419:Bacteria; D016503:Drug Delivery Systems; D005768:Gastrointestinal Hormones; D041981:Gastrointestinal Tract; D006801:Humans; D009424:Nervous System Physiological Phenomena; D019936:Probiotics; D005680:gamma-Aminobutyric Acid | BioEssays : news and reviews in molecular, cellular and developmental biology | 2,011 | D000893:Anti-Inflammatory Agents; D005768:Gastrointestinal Hormones; D005680:gamma-Aminobutyric Acid |
Defense mechanisms against herbivory in Picea: sequence evolution and expression regulation of gene family members in the phenylpropanoid pathway. | BACKGROUND
In trees, a substantial amount of carbon is directed towards production of phenolics for development and defense. This metabolic pathway is also a major factor in resistance to insect pathogens in spruce. In such gene families, environmental stimuli may have an important effect on the evolutionary fate of du... | 10.1186/1471-2164-12-608 | 22,177,423 | D019143:Evolution, Molecular; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D010666:Phenylpropionates; D028222:Picea; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci | BMC genomics | 2,011 | D010666:Phenylpropionates |
What is the incidence of kidney stones after chemotherapy in patients with lymphoproliferative or myeloproliferative disorders? | INTRODUCTION
This study describes the incidence and risk factors of de novo nephrolithiasis among patients with lymphoproliferative or myeloproliferative diseases who have undergone chemotherapy.
MATERIALS AND METHODS
From 2001 to 2011, patients with lymphoproliferative or myeloproliferative disorders treated with ch... | 10.1590/S1677-5538.IBJU.2014.06.08 | 25,615,245 | D000328:Adult; D000368:Aged; D000493:Allopurinol; D002118:Calcium; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006934:Hypercalcemia; D033461:Hyperuricemia; D007669:Kidney Calculi; D008232:Lymphoproliferative Disorders; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009196:Myelop... | International braz j urol : official journal of the Brazilian Society of Urology | 2,014 | D000493:Allopurinol; D011188:Potassium; D002118:Calcium |
Copper-Containing Anti-Biofilm Nanofiber Scaffolds as a Wound Dressing Material. | Copper particles were incorporated into nanofibers during the electrospinning of poly-D,L-lactide (PDLLA) and poly(ethylene oxide) (PEO). The ability of the nanofibers to prevent Pseudomonas aeruginosa PA01 and Staphylococcus aureus (strain Xen 30) to form biofilms was tested. Nanofibers containing copper particles (Cu... | 10.1371/journal.pone.0152755 | 27,028,292 | D000900:Anti-Bacterial Agents; D001458:Bandages; D018441:Biofilms; D003300:Copper; D057139:Nanofibers; D011550:Pseudomonas aeruginosa; D013211:Staphylococcus aureus; D013499:Surface Properties | PloS one | 2,016 | D000900:Anti-Bacterial Agents; D003300:Copper |
[Effects of opioid neuropeptides on the prostaglandin system and lipid peroxidation processes in the myocardium during stress-induced damage]. | The stress was subsequenced by lowering of Thromboxane A2 level and activation of peroxidation of lipids without any changes of prostacyclin content in myocardium. It was found that the pre-increase of the opioid peptides in blood plasma led to the absence of prostacyclin and thromboxane dynamic and myocardial lipids p... | 1,893,188 | D000818:Animals; D000897:Anti-Ulcer Agents; D016308:Enkephalin, Leucine-2-Alanine; D011464:Epoprostenol; D015227:Lipid Peroxidation; D008297:Male; D009206:Myocardium; D011453:Prostaglandins; D051381:Rats; D013315:Stress, Psychological; D013565:Sympatholytics; D013928:Thromboxane A2 | Biulleten' eksperimental'noi biologii i meditsiny | 1,991 | D000897:Anti-Ulcer Agents; D011453:Prostaglandins; D013565:Sympatholytics; D013928:Thromboxane A2; D016308:Enkephalin, Leucine-2-Alanine; D011464:Epoprostenol; C040996:enkephalin-Leu, Ala(2)-Arg(6)- | |
Red blood cell changes during the evolution of the sickle cell painful crisis. | A longitudinal study of the red blood cell (RBC) deformability, percent of dense erythrocytes, and hematologic parameters has been conducted during 117 painful crises affecting 36 patients with sickle cell anemia between January, 1985 and December, 1990. RBC deformability was determined by osmotic gradient ektacytometr... | 1,562,742 | D000328:Adult; D000755:Anemia, Sickle Cell; D004907:Erythrocyte Deformability; D004912:Erythrocytes; D005260:Female; D006760:Hospitalization; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009994:Osmolar Concentration; D010146:Pain | Blood | 1,992 | ||
Gender-specific psychosocial outcome for women with epilepsy. | The objective of the study described here was to compare gender-specific differences of the personal impact of juvenile myoclonic epilepsy (JME) and temporal lobe epilepsy (TLE). We interviewed consecutive men and women with JME or TLE attending a tertiary epilepsy center to characterize their clinical and psychologica... | 10.1016/j.yebeh.2010.10.013 | 21,093,381 | D000328:Adult; D000339:Affect; D000927:Anticonvulsants; D016009:Chi-Square Distribution; D004569:Electroencephalography; D004651:Employment; D004833:Epilepsy, Temporal Lobe; D005221:Fatigue; D005260:Female; D006801:Humans; D008297:Male; D008393:Marriage; D001523:Mental Disorders; D020190:Myoclonic Epilepsy, Juvenile; D... | Epilepsy & behavior : E&B | 2,011 | D000927:Anticonvulsants |
SSc and the 2013 diagnostic criteria: the case of Paul Klee's manual pathology and dysgraphia. | The German-Swiss modernist painter Paul Klee (1879-1940) suffered in the final years of his life from a severe illness, diagnosed in 1936 as scleroderma, later renamed SSc. New classification criteria for this disease issued in 2013 now allow for a diagnosis to be confirmed. Important for this process, however, is the ... | 10.1007/s10067-014-2785-x | 25,236,296 | D000381:Agraphia; D005197:Famous Persons; D049673:History, 20th Century; D006801:Humans; D008297:Male; D010151:Paintings; D012595:Scleroderma, Systemic; D013557:Switzerland | Clinical rheumatology | 2,014 | |
Three-dimensional chiral microstructures fabricated by structured optical vortices in isotropic material. | Optical vortices, a type of structured beam with helical phase wavefronts and 'doughnut'-shaped intensity distributions, have been used to fabricate chiral structures in metals and spiral patterns in anisotropic polarization-dependent azobenzene polymers. However, in isotropic polymers, the fabricated microstructures a... | 10.1038/lsa.2017.11 | 30,167,269 | Light, science & applications | 2,017 | ||
Knee Pain and Structural Damage as Risk Factors for Incident Widespread Pain: Data From the Multicenter Osteoarthritis Study. | OBJECTIVE
To examine the longitudinal relationship of knee pain, radiographic osteoarthritis (OA), symptomatic knee OA, and knee pain severity to incident widespread pain.
METHODS
The Multicenter Osteoarthritis Study is a longitudinal cohort of persons with or at risk of knee OA. Participants were characterized as ha... | 10.1002/acr.23086 | 27,636,245 | D000368:Aged; D018771:Arthralgia; D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee; D010147:Pain Measurement; D011446:Prospective Studies; D012307:Risk Factors | Arthritis care & research | 2,017 | |
Analysis of the excision repair of nondimer DNA damage induced by solar ultraviolet radiation in ICR 2A frog cells. | The excision repair of solar uv-induced nondimer DNA damage was examined in ICR 2A frog cells through the use of the bromodeoxyuridine (BrdUrd) photolysis assay. A relatively pure population of nondimer DNA photoproducts was induced by irradiation of ICR 2A cells with the Mylar-filtered solar ultraviolet (uv) wavelengt... | 3,875,117 | D000818:Animals; D002460:Cell Line; D004247:DNA; D004260:DNA Repair; D066298:In Vitro Techniques; D011894:Rana pipiens; D013472:Sunlight; D014466:Ultraviolet Rays | Radiation research | 1,985 | D004247:DNA | |
[Does the use of a polyurethane patch in the CVC dressing further reduce the risk of infection compared with sterile gauze dressing?]. | Half of the patients hospitalized in intensive care units have a central venous catheter (CVC) inserted. Management of CVC is not simple and the wrong medication on the insertion site may cause many complications including sepsis. Among the various modes of dressing are transparent polyurethane patches and sterile gauz... | 21,753,246 | D001458:Bandages; D055499:Catheter-Related Infections; D002405:Catheterization, Central Venous; D006801:Humans; D011140:Polyurethanes | Le infezioni in medicina | 2,011 | D011140:Polyurethanes | |
Cholera toxin structure, gene regulation and pathophysiological and immunological aspects. | Many notions regarding the function, structure and regulation of cholera toxin expression have remained essentially unaltered in the last 15 years. At the same time, recent findings have generated additional perspectives. For example, the cholera toxin genes are now known to be carried by a non-lytic bacteriophage, a p... | 10.1007/s00018-008-7496-5 | 18,278,577 | D000276:Adjuvants, Immunologic; D001327:Autoimmune Diseases; D001427:Bacterial Toxins; D002771:Cholera; D002772:Cholera Toxin; D022121:Cholera Vaccines; D004768:Enterotoxins; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D006967:Hypersensitivity; D018928:Immunity, Muc... | Cellular and molecular life sciences : CMLS | 2,008 | D000276:Adjuvants, Immunologic; D001427:Bacterial Toxins; D022121:Cholera Vaccines; D004768:Enterotoxins; D029968:Escherichia coli Proteins; D002772:Cholera Toxin; C027538:heat-labile enterotoxin, E coli |
Outbreak of viral hepatitis B in a rural community in India linked to inadequately sterilized needles and syringes. | In India, virtually all outbreaks of viral hepatitis are considered to be due to faeco-orally transmitted hepatitis E virus. Recently, a cluster of 15 cases of viral hepatitis B was found in three villages in Gujarat State. The cases were epidemiologically linked to the use of inadequately sterilized needles and syring... | 9,615,501 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016000:Cluster Analysis; D004196:Disease Outbreaks; D004866:Equipment Contamination; D005260:Female; D006509:Hepatitis B; D003699:Hepatitis D; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009339:Needles; D011159:Population Surveillance; D012... | Bulletin of the World Health Organization | 1,998 | ||
Female Urethra Adenocarcinoma. | Female urethra adenocarcinoma (FUA) is a rare aggressive tumor that occurs in Skene ducts and glands. It is associated with a relatively poor prognosis. The aim of this review was to evaluate FUA in terms of epidemiology, risk factors, diagnosis, natural history of disease, modalities of treatment, and outcomes. These ... | 10.1016/j.clgc.2017.10.006 | 29,113,768 | D000230:Adenocarcinoma; D003131:Combined Modality Therapy; D003558:Cystoscopy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D011788:Quality of Life; D014523:Urethral Neoplasms | Clinical genitourinary cancer | 2,018 | |
Evaluation of the ocular surface characteristics and Demodex infestation in paediatric and adult blepharokeratoconjunctivitis. | BACKGROUND
To evaluate the ocular surface characteristics and the infestation of Demodex in Chinese paediatric and adult blepharokeratoconjunctivitis (BKC).
METHODS
Fifty consecutive patients with BKC and 50 age- and sex-matched healthy subjects were enrolled. Lid margin characteristics and corneal disorders were eva... | 10.1186/s12886-019-1074-5 | 30,845,992 | D000293:Adolescent; D000328:Adult; D001762:Blepharitis; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003231:Conjunctivitis; D003316:Corneal Diseases; D016510:Corneal Neovascularization; D057210:Delayed Diagnosis; D005140:Eyelashes; D005141:Eyelid Diseases; D005143:Eyelids; D005260:Female; D00... | BMC ophthalmology | 2,019 | |
A case of self-harm by alcohol intoxication resulted in unintended in-hospital death. | In-hospital hanging during a confusional state from alcohol intoxication is rare. To treat cases of acute alcohol intoxication, careful observation will be needed to avoid accidental psychological reactions. | 10.1002/ccr3.51 | 25,356,242 | Clinical case reports | 2,014 | ||
Dual-function antiandrogen/HDACi hybrids based on enzalutamide and entinostat. | The combination of androgen receptor antagonists with histone deacetylase inhibitors (HDACi) has been shown to be more effective than antiandrogens alone in halting growth of prostate cancer cell lines. Here we have designed, synthesized and assessed a series of antiandrogen/HDACi hybrids by combining structural featur... | 10.1016/j.bmcl.2021.128441 | 34,767,912 | D000726:Androgen Antagonists; D000970:Antineoplastic Agents; D001549:Benzamides; D049109:Cell Proliferation; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D031541:Fluorescence Resonance Energy Transfer; D005470:Fluorometry; D056572:Histone Deacetylase Inhibit... | Bioorganic & medicinal chemistry letters | 2,022 | D000726:Androgen Antagonists; D000970:Antineoplastic Agents; D001549:Benzamides; D056572:Histone Deacetylase Inhibitors; D009570:Nitriles; D011725:Pyridines; C118739:entinostat; D010669:Phenylthiohydantoin; C540278:enzalutamide; D006655:Histone Deacetylases |
Malignant Epithelial Tumors of the Ovary: Pathogenesis and Imaging. | Epithelial ovarian neoplasms (EON) constitute the majority of ovarian cancers. Among EON, high-grade serous carcinoma (HGSC) is the most common and most likely to present at an advanced stage. Radiologists should recognize the imaging features associated with HGSC, particularly at ultrasound and MR imaging. Computed to... | 10.1016/j.rcl.2023.02.003 | 37,169,424 | D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms; D002277:Carcinoma | Radiologic clinics of North America | 2,023 | |
The Assessment of Health-Related Quality of Life in Patients With Chronic Liver Disease: A Single-Center Study. | Aim The aim of this study was to investigate the factors affecting health-related quality of life (HRQOL) in Nepalese patients with chronic liver disease (CLD). Methods In this study, HRQOL was measured with validated Nepali versions of the short-form 36 (SF-36) survey. Socioeconomic factors, etiology, laboratory param... | 10.7759/cureus.10727 | 33,145,133 | Cureus | 2,020 | ||
Evaluation of somatic copy number estimation tools for whole-exome sequencing data. | Whole-exome sequencing (WES) has become a standard method for detecting genetic variants in human diseases. Although the primary use of WES data has been the identification of single nucleotide variations and indels, these data also offer a possibility of detecting copy number variations (CNVs) at high resolution. Howe... | 10.1093/bib/bbv055 | 26,210,357 | D000465:Algorithms; D002874:Chromosome Mapping; D056915:DNA Copy Number Variations; D059472:Exome; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017422:Sequence Analysis, DNA; D012984:Software | Briefings in bioinformatics | 2,016 | |
Phrenicoabdominal venotomy for tumor thrombectomy in dogs with adrenal neoplasia and suspected vena caval invasion. | OBJECTIVE
To describe a technique for tumor thrombectomy by phrenicoabdominal venotomy in dogs with adrenal neoplasia and suspected caval invasion and to report complications and outcomes associated with the procedure.
STUDY DESIGN
Retrospective case series.
ANIMALS
Eight client-owned dogs with invasive adrenal tum... | 10.1111/vsu.12728 | 28,990,687 | D000310:Adrenal Gland Neoplasms; D000315:Adrenalectomy; D018268:Adrenocortical Carcinoma; D000818:Animals; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D008297:Male; D009362:Neoplasm Metastasis; D011183:Postoperative Complications; D012189:Retrospective Studies; D017131:Thrombectomy; D014057:Tomography, X-Ray Co... | Veterinary surgery : VS | 2,018 | |
'I shouldn't have had to push and fight': health care experiences of persons with dementia and their caregivers in primary care. | OBJECTIVES
Most persons with dementia (PWD) receive the majority of their care from primary care providers (PCPs). A number of challenges have been identified with providing quality dementia care in primary care from the perspective of PCP. However, less is known of the primary care health care experience (HCE) of PWD ... | 10.1080/13607863.2016.1159280 | 26,982,159 | D000368:Aged; D000369:Aged, 80 and over; D017028:Caregivers; D003704:Dementia; D005260:Female; D006297:Health Services Accessibility; D006801:Humans; D008297:Male; D008875:Middle Aged; D009864:Ontario; D062526:Patient Navigation; D011320:Primary Health Care; D036301:Qualitative Research | Aging & mental health | 2,017 | |
Immune mechanisms in C57B1 mice genetically resistant to Trypanosoma congolense infection. II. Aspects of the humoral response. | Some aspects of the humoral response in trypanotolerant C57B1 mice and susceptible A/J mice were investigated to determine the possible basis of trypanotolerance. When the hepatic uptake of 75Se-labelled T. congolense by infected mice was measured as an index of antibody production, it was found that only C57B1 mice co... | 10.1111/j.1365-3024.1983.tb00774.x | 6,657,296 | D000818:Animals; D000917:Antibody Formation; D005260:Female; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D051381:Rats; D014346:Trypanosoma brucei brucei; D014348:Trypanosoma congolense; D014353:Trypanosomiasis, African; D014611:Vaccination; D014612:Vaccines | Parasite immunology | 1,983 | D014612:Vaccines |
Drug drug interaction extraction from biomedical literature using syntax convolutional neural network. | MOTIVATION
Detecting drug-drug interaction (DDI) has become a vital part of public health safety. Therefore, using text mining techniques to extract DDIs from biomedical literature has received great attentions. However, this research is still at an early stage and its performance has much room to improve.
RESULTS
In... | 10.1093/bioinformatics/btw486 | 27,466,626 | D057225:Data Mining; D004347:Drug Interactions; D006801:Humans; D016571:Neural Networks, Computer; D011381:Programming Languages; D011642:Publications | Bioinformatics (Oxford, England) | 2,016 | |
[Application of bacterial thermo-and phagelysates for suppression of malignant tumor growth in experimental studies: 1. Anticancer efficacy of thermo- and phagelysates of E.coli]. | Immunotherapy is considered as one of the promising treatment strategies for patients with malignant tumors. In the presented work antitumor effects of E.coli thermo- and phagelysates on Ehrlich carcinoma growth in mice have been studied. The treatment efficacy was evaluated by estimation of dynamic changes in volume o... | 22,392,782 | D000818:Animals; D001435:Bacteriophages; D002286:Carcinoma, Ehrlich Tumor; D002457:Cell Extracts; D002471:Cell Transformation, Neoplastic; D004926:Escherichia coli; D006801:Humans; D051379:Mice; D008962:Models, Theoretical; D009374:Neoplasms, Experimental; D013696:Temperature | Georgian medical news | 2,012 | C030259:Broncho-Vaxom; D002457:Cell Extracts | |
Safety and efficacy of oral fluorescein angiography in detecting macular edema in comparison with spectral-domain optical coherence tomography. | PURPOSE
To evaluate the safety of oral fluorescein angiography (FA) and to compare its efficacy in detection of macular edema (ME) with spectral-domain optical coherence tomography (SD-OCT).
METHODS
Results of imaging studies for 1,928 eyes of 1,019 patients who had simultaneously undergone both oral FA and SD-OCT by... | 10.1097/IAE.0b013e318285cd84 | 23,584,697 | D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D019793:Fluorescein; D005451:Fluorescein Angiography; D005456:Fluorescent Dyes; D006801:Humans; D008269:Macular Edema; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D... | Retina (Philadelphia, Pa.) | 2,013 | D005456:Fluorescent Dyes; D019793:Fluorescein |
Conversion Disorder Manifesting as Functional Visual Loss. | BACKGROUND
Children with conversion disorder experience neurological symptoms without a definable organic cause. Clinical presentation of conversion disorders is uncommon in the emergency department (ED).
CASE REPORT
An 11-year-old previously healthy girl presented to the ED for management of lobar pneumonia. She dev... | 10.1016/j.jemermed.2019.02.008 | 31,003,815 | D000900:Anti-Bacterial Agents; D001766:Blindness; D002443:Ceftriaxone; D002648:Child; D003291:Conversion Disorder; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D011014:Pneumonia | The Journal of emergency medicine | 2,019 | D000900:Anti-Bacterial Agents; D002443:Ceftriaxone |
A Variety of Nucleic Acid Species Are Sensed by cGAS, Implications for Its Diverse Functions. | Cyclic GMP-AMP synthase (cGAS) recognizes double-stranded DNA (dsDNA) derived from invading pathogens and induces an interferon response via activation of the key downstream adaptor protein stimulator of interferon genes (STING). This is the most classic biological function of the cGAS-STING signaling pathway and is cr... | 10.3389/fimmu.2022.826880 | 35,185,917 | D000818:Animals; D001327:Autoimmune Diseases; D001343:Autophagy; D016922:Cellular Senescence; D004247:DNA; D006801:Humans; D007249:Inflammation; D007370:Interferon Type I; D008565:Membrane Proteins; D009696:Nucleic Acids; D009713:Nucleotidyltransferases; D015398:Signal Transduction | Frontiers in immunology | 2,022 | D007370:Interferon Type I; D008565:Membrane Proteins; D009696:Nucleic Acids; C532857:STING1 protein, human; D004247:DNA; D009713:Nucleotidyltransferases; C578390:cGAS protein, human |
Vertical distribution, contamination status and ecological risk assessment of heavy metals in core sediments from a mangrove-dominated tropical river. | Understanding the vertical distribution of heavy metals aids in tracing the contamination history, however, it is limited for mangrove-dominated river. Thus, this study aimed to assess the vertical distribution of nine heavy metals and their possible ecological risk in several layers of core sediments from a mangrove-d... | 10.1016/j.marpolbul.2023.114804 | 36,924,691 | D045483:Rivers; D002104:Cadmium; D019015:Geologic Sediments; D004784:Environmental Monitoring; D014874:Water Pollutants, Chemical; D019216:Metals, Heavy; D018570:Risk Assessment; D002681:China | Marine pollution bulletin | 2,023 | D002104:Cadmium; D014874:Water Pollutants, Chemical; D019216:Metals, Heavy |
An international RAND/UCLA expert panel to determine the optimal diagnosis and management of burn inhalation injury. | BACKGROUND
Burn inhalation injury (BII) is a major cause of burn-related mortality and morbidity. Despite published practice guidelines, no consensus exists for the best strategies regarding diagnosis and management of BII. A modified DELPHI study using the RAND/UCLA (University of California, Los Angeles) Appropriaten... | 10.1186/s13054-023-04718-w | 38,012,797 | D006801:Humans; D000111:Acetylcysteine; D002056:Burns; D012121:Respiration, Artificial; D006493:Heparin; D055370:Lung Injury; D000420:Albuterol | Critical care (London, England) | 2,023 | D000111:Acetylcysteine; D006493:Heparin; D000420:Albuterol |
[New ultrasonic images in patients with lithiasis after undergoing extracorporeal shock wave lithotripsy]. | Evaluation and follow-up of patients submitted to extracorporeal shock wave lithotripsy (ESWL) by ultrasonography is a good adjunct to radiology. Plain x-ray and ultrasound imaging permit following the course of stone patients submitted to treatment by ESWL without recurring to IVP in most of the cases. One-thousand ki... | 2,782,965 | D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D008096:Lithotripsy; D014465:Ultrasonics; D014545:Urinary Calculi | Archivos espanoles de urologia | 1,989 | ||
Are the components of the Asthma Management Plan important in managing childhood asthma? A survey of general practitioners. | AIM
To gauge the importance and relevance placed by general practitioners on components of the National Asthma Campaign's 'Six step' Asthma Management Plan for childhood asthma.
METHOD
A cross sectional postal survey of a national randomised sample of 824 GPs.
RESULTS
Each component was considered to be 'quite' or ... | 12,833,778 | D000293:Adolescent; D000328:Adult; D018927:Anti-Asthmatic Agents; D001249:Asthma; D001291:Attitude of Health Personnel; D002648:Child; D002675:Child, Preschool; D002983:Clinical Competence; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005194:Family Practice; D005260:Female; D019983:Guideline Adherenc... | Australian family physician | 2,003 | D018927:Anti-Asthmatic Agents | |
Optically detected magnetic resonance study of the interaction of an arsenic(III) derivative of cacodylic acid with EcoRI methyl transferase. | The interaction of the enzyme Escherichia coli RI methyl transferase (methylase) with an arsenic(III) derivative of cacodylic acid has been investigated by optical detection of triplet-state magnetic resonance (ODMR) spectroscopy in zero applied magnetic field. The reactive derivative (CH3)2AsSR is formed by the reduct... | 10.1021/bi00232a029 | 2,021,649 | D001151:Arsenic; D001665:Binding Sites; D001976:Bromouracil; D002101:Cacodylic Acid; D002352:Carrier Proteins; D004247:DNA; D004229:Dithiothreitol; D058973:Folate Receptors, GPI-Anchored; D006868:Hydrolysis; D007700:Kinetics; D008163:Luminescent Measurements; D009682:Magnetic Resonance Spectroscopy; D008623:Mercaptoeth... | Biochemistry | 1,991 | D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D011956:Receptors, Cell Surface; D001976:Bromouracil; D008623:Mercaptoethanol; D004247:DNA; D002101:Cacodylic Acid; C020098:DNA modification methylase EcoRI; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific); D001151:Arsenic; D004229:Dithiot... |
Electrophysiologic Study versus Electrocardiographic Monitoring (ESVEM): a critical appraisal. | This paper reviews the Electrophysiologic Study versus Holter Monitoring (ESVEM) trial, addressing several areas of concern including potential enrollment bias, an inadequate electrophysiologic testing protocol during drug therapy, and an unexpectedly high recurrence rate in patients deemed to be controlled by either m... | 10.1016/s0197-2456(96)00042-6 | 8,877,265 | D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac; D016757:Death, Sudden, Cardiac; D015716:Electrocardiography, Ambulatory; D004594:Electrophysiology; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D017180:Tachycardia, Ventricular; D014481:United States; D014693:Ventricular Fibrillation | Controlled clinical trials | 1,996 | D000889:Anti-Arrhythmia Agents |
Sixteen years' experience with therapeutic donor insemination. | Therapeutic donor insemination was performed in 107 "normal" patients, using an intracervical technique and two inseminations per cycle on alternate days. Seventy-seven patients became pregnant (71.9%), and 103 conceptions occurred. Of these pregnancies, 72.8% occurred in the first 3 months of treatment and 95.2% occur... | 10.1016/s0015-0282(16)41294-x | 1,157,965 | D000022:Abortion, Spontaneous; D005260:Female; D006801:Humans; D007248:Infertility, Male; D007315:Insemination, Artificial; D007316:Insemination, Artificial, Heterologous; D008297:Male; D010352:Patient Dropouts; D011247:Pregnancy; D012744:Sex Ratio | Fertility and sterility | 1,975 | |
Mutation in the lysA gene impairs the symbiotic properties of Mesorhizobium ciceri. | A Tn5-induced mutant of Mesorhizobium ciceri, TL28, requiring the amino acid lysine for growth on minimal medium was isolated and characterized. The Tn5 insertion in the mutant strain TL28 was located on a 6.8-kb EcoRI fragment of the chromosomal DNA. Complementation analysis with cloned DNA indicated that 1.269 kb of ... | 10.1007/s00203-009-0527-2 | 20,020,102 | D020561:Alphaproteobacteria; D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D002262:Carboxy-Lyases; D029863:Cicer; D003001:Cloning, Molecular; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D029382:Dicarboxylic Acid Transporters; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacter... | Archives of microbiology | 2,010 | D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D029382:Dicarboxylic Acid Transporters; D012329:RNA, Bacterial; D002262:Carboxy-Lyases |
Efficiency of RO/NF membranes at the removal of veterinary antibiotics. | The production of pharmaceuticals has increased rapidly during the last several decades as they have been used for the health of both humans and animals. Routes of environmental exposure include the release of treated wastewater, the land disposal of livestock manures and municipal biosolids (i.e. sewage sludge), as we... | 10.2166/wst.2012.855 | 22,233,911 | D000900:Anti-Bacterial Agents; D005374:Filtration; D008567:Membranes, Artificial; D036103:Nanotechnology; D009995:Osmosis; D016062:Porosity; D019155:Veterinary Drugs; D014865:Waste Disposal, Fluid; D014874:Water Pollutants, Chemical; D018508:Water Purification | Water science and technology : a journal of the International Association on Water Pollution Research | 2,012 | D000900:Anti-Bacterial Agents; D008567:Membranes, Artificial; D019155:Veterinary Drugs; D014874:Water Pollutants, Chemical |
Deaths observed in Medicare beneficiaries: average attributable fraction and its longitudinal extension for many diseases. | Calculating the longitudinal extension of the average attributable fraction (LE-AAF) for many risk factors (RFs) requires a two-stage computational process using only those combinations of RFs observed in the dataset. We first screen candidates RFs in a Cox Model, and assuming piecewise constant hazards, use pooled log... | 10.1002/sim.5337 | 22,415,597 | D002908:Chronic Disease; D003627:Data Interpretation, Statistical; D006801:Humans; D008137:Longitudinal Studies; D006278:Medicare; D015233:Models, Statistical; D012307:Risk Factors; D014481:United States | Statistics in medicine | 2,012 | |
The pros and cons of plant estrogens for menopause. | Concerns pertaining to the risk of estrogen exposure through HT have prompted an increase in the use of natural alternatives. Phytoestrogens may provide postmenopausal women with a practical alternative and many women have already begun to utilize phytoestrogen supplements. However, research regarding the efficacy of p... | 23,270,754 | D001284:Atrophy; D003374:Coumarins; D020847:Estrogen Receptor Modulators; D015914:Estrogen Replacement Therapy; D005260:Female; D019584:Hot Flashes; D006801:Humans; D048789:Phytoestrogens; D017698:Postmenopause; D014621:Vagina; D014666:Vasomotor System | The Journal of steroid biochemistry and molecular biology | 2,014 | D003374:Coumarins; D020847:Estrogen Receptor Modulators; D048789:Phytoestrogens; C505898:coumestan | |
Prediction of verbal memory decline after epilepsy surgery in children: effectiveness of Wada memory asymmetries. | PURPOSE
Differences in Wada memory performance after left and right amobarbital injection are powerful predictors of pre- to postoperative memory change among adult epilepsy patients after anterior temporal lobectomy. It is unknown, however, whether these Wada memory asymmetries apply to children who undergo focal cort... | 10.1111/j.0013-9580.2005.41704.x | 15,660,774 | D000293:Adolescent; D000654:Amobarbital; D002540:Cerebral Cortex; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008568:Memory; D008569:Memory Disorders; D009483:Neuropsychological Tests; D011183:Postoperative Complications; D0112... | Epilepsia | 2,005 | D000654:Amobarbital |
Social personality polymorphism and the spread of invasive species: a model. | Ecological invasions are a major worldwide problem exacting tremendous economic and ecological costs. Efforts to explain variability in invasion speed and impact by searching for combinations of ecological conditions and species traits associated with invasions have met with mixed success. We use a simulation model tha... | 10.1086/658174 | 21,460,537 | D025041:Animal Migration; D000818:Animals; D017753:Ecosystem; D056084:Genetic Fitness; D058865:Introduced Species; D008954:Models, Biological; D010641:Phenotype; D011110:Polymorphism, Genetic; D011156:Population Density; D011157:Population Dynamics; D012919:Social Behavior | The American naturalist | 2,011 | |
Schistosoma mansoni soluble egg antigens trigger erythrocyte cell death. | Estimated to affect nearly 300 million people worldwide, schistosomiasis is caused by parasitic flatworms of the genus Schistosoma. The major pathological consequences of chronic schistosomiasis are associated with soluble egg antigens (SEA) secreted from schistosome egg deposits in liver and other organs. The vigorous... | 10.1159/000322344 | 21,063,114 | D000814:Aniline Compounds; D000818:Animals; D000947:Antigens, Helminth; D017209:Apoptosis; D002118:Calcium; D004912:Erythrocytes; D005434:Flow Cytometry; D005456:Fluorescent Dyes; D051379:Mice; D010063:Ovum; D012550:Schistosoma mansoni; D014966:Xanthenes | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2,010 | D000814:Aniline Compounds; D000947:Antigens, Helminth; D005456:Fluorescent Dyes; D014966:Xanthenes; C059715:Fluo-3; D002118:Calcium |
Effects of therapeutic doses of salbutamol alone and combined with beclomethasone dipropionate on airway responsiveness and cyclic AMP plasma levels in asthmatic patients. | Twelve asthmatic patients received by inhalation for 2 weeks, in a double-blind, cross-over design, beclomethasone dipropionate (BDP; 600 micrograms/day) plus salbutamol (S; 900 micrograms/day), or S (900 micrograms/day) alone. Before and after each treatment course the subjects received intravenous cumulative doses of... | 10.1159/000196178 | 8,393,581 | D000280:Administration, Inhalation; D000328:Adult; D000420:Albuterol; D001249:Asthma; D001507:Beclomethasone; D000242:Cyclic AMP; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged | Respiration; international review of thoracic diseases | 1,993 | D000242:Cyclic AMP; D001507:Beclomethasone; D000420:Albuterol |
New Structural Templates for Clinically Validated and Novel Targets in Antimicrobial Drug Research and Development. | The development of bacterial resistance against current antibiotic drugs necessitates a continuous renewal of the arsenal of efficacious drugs. This imperative has not been met by the output of antibiotic research and development of the past decades for various reasons, including the declining efforts of large pharma c... | 10.1007/82_2016_501 | 27,704,270 | D000818:Animals; D000900:Anti-Bacterial Agents; D001419:Bacteria; D001424:Bacterial Infections; D015195:Drug Design; D024881:Drug Resistance, Bacterial; D006801:Humans; D015394:Molecular Structure | Current topics in microbiology and immunology | 2,016 | D000900:Anti-Bacterial Agents |
Implications of interprofessional primary care team characteristics for health services and patient health outcomes: A systematic review with narrative synthesis. | Interprofessional primary care (IPPC) teams are promoted as an alternative to single profession physician practices in primary care with focus on preventive care and chronic disease management. Characteristics of teams can have an impact on their performance. We synthesized quantitative, qualitative or mixed-methods ev... | 10.1016/j.healthpol.2019.03.015 | 30,955,711 | D003299:Cooperative Behavior; D017598:Efficiency, Organizational; D006801:Humans; D007400:Interprofessional Relations; D017063:Outcome Assessment, Health Care; D010348:Patient Care Team; D011320:Primary Health Care | Health policy (Amsterdam, Netherlands) | 2,019 | |
Systematic analysis of severity in a widely used cognitive depression model for mice. | Animal models in psychiatric research are indispensable for insights into mechanisms of behaviour and mental disorders. Distress is an important aetiological factor in psychiatric diseases, especially depression, and is often used to mimic the human condition. Modern bioethics requires balancing scientific progress wit... | 10.1177/0023677219874831 | 31,575,329 | D000827:Animal Welfare; D000818:Animals; D001835:Body Weight; D003345:Corticosterone; D003863:Depression; D004195:Disease Models, Animal; D006380:Helplessness, Learned; D051379:Mice; D009425:Nesting Behavior; D012720:Severity of Illness Index; D013315:Stress, Psychological | Laboratory animals | 2,020 | D003345:Corticosterone |
The Lived Experience of Myasthenia Gravis: A Patient-Led Analysis. | INTRODUCTION
A greater understanding of the reality of living with myasthenia gravis (MG) may improve management and outcomes for patients. However, there is little published data on the patient perspective of how MG impacts life. Our objective was to reveal the lived experience of MG from the patient perspective.
ME... | 10.1007/s40120-021-00285-w | 34,687,427 | Neurology and therapy | 2,021 | ||
[An increase in the excitability of the cortical neurons during reinforcing stimulation of the lateral hypothalamus]. | Pyramidal tract response (PTR) was recorded from unanaesthetized rabbits. The following three experimental paradigms were used which imitated behavioural conditioning procedures: pairing of direct stimulation of two cortical points; similar pairing conjoint with stimulation of additional reinforcing the lateral hypotha... | 2,630,918 | D000818:Animals; D002540:Cerebral Cortex; D003214:Conditioning, Classical; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D007026:Hypothalamic Area, Lateral; D009474:Neurons; D011712:Pyramidal Tracts; D011817:Rabbits; D012054:Reinforcement, Psychology; D013569:Synapses | Neirofiziologiia = Neurophysiology | 1,989 | ||
Improving the Laboratory Diagnosis of M-like Variants Related to Alpha1-Antitrypsin Deficiency. | Alpha1-antitrypsin (AAT) is a serine protease inhibitor that is encoded by the highly polymorphic SERPINA1 gene. Mutations in this gene can lead to AAT deficiency (AATD), which is associated with an increased risk of lung and/or liver disease. On the basis of electrophoretic migration, AAT variants are named with capit... | 10.3390/ijms23179859 | 36,077,263 | D000483:Alleles; D019411:Clinical Laboratory Techniques; D005838:Genotype; D006801:Humans; D010641:Phenotype; D012189:Retrospective Studies; D000515:alpha 1-Antitrypsin; D019896:alpha 1-Antitrypsin Deficiency | International journal of molecular sciences | 2,022 | D000515:alpha 1-Antitrypsin |
[Evaluation and improvement of a measure of drug name similarity, vwhtfrag, in relation to subjective similarities and experimental error rates]. | Confusion of drug names is one of the most common causes of drug-related medical errors. A similarity measure of drug names, "vwhtfrag", was developed to discriminate whether drug name pairs are likely to cause confusion errors, and to provide information that would be helpful to avoid errors. The aim of the present st... | 10.1248/yakushi.132.525 | 22,465,931 | D004192:Discrimination, Psychological; D006801:Humans; D008037:Linguistics; D008508:Medication Errors; D010595:Pharmacists; D013334:Students | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan | 2,012 |
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