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[Acidification of the stomach contents of weaned piglets--effect of feed quantity and composition]. | The pH in the stomach chyme (5-8 hours past offering the diet) of reared piglets was strongly correlated to the ingested feed quantity, a complete acidification of the stomach contents occurred in restrictively fed piglets (15 g diet/kg BW) only. Feeding ad libitum resulted in comparable low pH values in the fundus and... | 2,219,106 | D000821:Animal Feed; D000818:Animals; D002119:Calcium Carbonate; D004435:Eating; D005561:Formates; D005766:Gastrointestinal Contents; D006851:Hydrochloric Acid; D006863:Hydrogen-Ion Concentration; D007773:Lactates; D019344:Lactic Acid; D013552:Swine; D014886:Weaning | Tierarztliche Praxis | 1,990 | D005561:Formates; D007773:Lactates; C030544:formic acid; D019344:Lactic Acid; D002119:Calcium Carbonate; D006851:Hydrochloric Acid | |
QTAIM analysis of ligand properties and mechanisms of tuning of 6-membered ring N-heterocyclic carbenes in transition metal complexes through ring-substituent variation. | Tuning of the ligand properties of a series of N-heterocyclic carbenes has previously been achieved through the variation of substituents at the ring boron sites. Analysis of the topology of the electron density using the quantum theory of atoms in molecules (QTAIM) reveals sensitive changes in the integrated atomic pr... | 10.1021/jp901533g | 19,548,646 | D006571:Heterocyclic Compounds; D008024:Ligands; D008697:Methane; D009942:Organometallic Compounds; D011789:Quantum Theory; D028561:Transition Elements | The journal of physical chemistry. A | 2,009 | D006571:Heterocyclic Compounds; D008024:Ligands; D009942:Organometallic Compounds; D028561:Transition Elements; C030011:carbene; D008697:Methane |
Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins. | Mcl-1 and Bcl-xL are crucial regulators of apoptosis, therefore dual inhibitors of both proteins could serve as promising new anticancer drugs. To design Mcl-1/Bcl-xL dual inhibitors, we performed structure-guided analyses of the corresponding selective Mcl-1 and Bcl-xL inhibitors. A cocrystal structure of a pyrazolo[1... | 10.1021/jm401170c | 24,215,352 | D000814:Aniline Compounds; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D001713:Biphenyl Compounds; D018360:Crystallography, X-Ray; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D011720:Pyrazoles; D011725:Pyridines; D013449:Sulfonamides; D... | Journal of medicinal chemistry | 2,013 | D000814:Aniline Compounds; D051017:Apoptosis Regulatory Proteins; D001713:Biphenyl Compounds; C579095:MCL1 protein, human; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D011720:Pyrazoles; D011725:Pyridines; D013449:Sulfonamides; D051020:bcl-X Protein; C528561:navitoclax |
Analysis of pir gene expression across the Plasmodium life cycle. | BACKGROUND
Plasmodium interspersed repeat (pir) is the largest multigene family in the genomes of most Plasmodium species. A variety of functions for the PIR proteins which they encode have been proposed, including antigenic variation, immune evasion, sequestration and rosetting. However, direct evidence for these is l... | 10.1186/s12936-021-03979-6 | 34,823,519 | D015870:Gene Expression; D017125:Genes, Protozoan; D008018:Life Cycle Stages; D005810:Multigene Family; D010962:Plasmodium berghei; D016788:Plasmodium chabaudi | Malaria journal | 2,021 | |
Evolution of disc degeneration in lumbar spine: a comparative histological study between herniated and postmortem retrieved disc specimens. | This is a prospective comparative histological study on blood supply between lumbar herniated discs and postmortem retrieved ones. The aim of this study is to observe the evolution of disc degeneration in relation to its blood supply changes. Disc vascularization is present early in life, but the nucleus pulposus becom... | 9,493,769 | D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002114:Calcinosis; D002356:Cartilage; D002648:Child; D005333:Fetus; D006801:Humans; D007223:Infant; D007403:Intervertebral Disc; D007405:Intervertebral Disc Displacement; D008159:Lumbar Vertebrae; D008875:Middle Aged | Journal of spinal disorders | 1,998 | ||
Evaluation of three commercial agar preparations for the presumptive identification of significant urinary isolates. | Three commercially available pre-poured chromogenic preparations--chromogenic urinary tract infection (UTI) medium (chromogenic UTI, Oxoid), CHROMagar Orientation (Becton Dickinson) and CPS ID2 (bioMérieux)--are evaluated in comparison to routine urine microbiology using cysteine lactose electrolyte-deficient (CLED) me... | 10.1080/09674845.2005.11732708 | 16,411,378 | D001419:Bacteria; D001424:Bacterial Infections; D015373:Bacterial Typing Techniques; D002863:Chromogenic Compounds; D003470:Culture Media; D004927:Escherichia coli Infections; D006801:Humans; D014552:Urinary Tract Infections; D014556:Urine | British journal of biomedical science | 2,005 | D002863:Chromogenic Compounds; D003470:Culture Media |
Silencing of Long Noncoding RNA SOX21-AS1 Relieves Neuronal Oxidative Stress Injury in Mice with Alzheimer's Disease by Upregulating FZD3/5 via the Wnt Signaling Pathway. | Alzheimer's disease (AD) represents a progressive neurodegenerative disorder characterized by distinctive neuropathological changes. Recently, long noncoding RNAs (lncRNAs) have become a key area of interest due to their potential in AD therapy. Hence, the aim of the current study was to investigate the effect of lncRN... | 10.1007/s12035-018-1299-y | 30,143,969 | D000544:Alzheimer Disease; D016229:Amyloid beta-Peptides; D000818:Animals; D017209:Apoptosis; D001483:Base Sequence; D059447:Cell Cycle Checkpoints; D005260:Female; D051157:Frizzled Receptors; D020868:Gene Silencing; D057809:HEK293 Cells; D006624:Hippocampus; D006801:Humans; D008297:Male; D008568:Memory; D051379:Mice; ... | Molecular neurobiology | 2,019 | D016229:Amyloid beta-Peptides; D051157:Frizzled Receptors; D062085:RNA, Long Noncoding; D012333:RNA, Messenger |
Drug therapy in the elderly. | Special considerations must be invoked when prescribing medications for the elderly. Although basic absorption is unchanged, many elderly patients are prone to chronic diarrhea or constipation, either of which may alter intestinal contact time and, thus, absorption. Concurrent use of such drugs as antacids or iron prep... | 760,438 | D000368:Aged; D000700:Analgesics; D000900:Anti-Bacterial Agents; D000959:Antihypertensive Agents; D004347:Drug Interactions; D004358:Drug Therapy; D006397:Hematinics; D006801:Humans; D007004:Hypoglycemic Agents; D007408:Intestinal Absorption; D004364:Pharmaceutical Preparations; D014149:Tranquilizing Agents | American family physician | 1,979 | D000700:Analgesics; D000900:Anti-Bacterial Agents; D000959:Antihypertensive Agents; D006397:Hematinics; D007004:Hypoglycemic Agents; D004364:Pharmaceutical Preparations; D014149:Tranquilizing Agents | |
Unveiling the early events of Pseudomonas aeruginosa adaptation in cystic fibrosis airway environment using a long-term in vitro maintenance. | Pseudomonas aeruginosa chronic infections are the major cause of high morbidity and mortality in cystic fibrosis (CF) patients due to the use of sophisticated mechanisms of adaptation, including clonal diversification into specialized CF-adapted phenotypes. In contrast to chronic infections, very little is known about ... | 10.1016/j.ijmm.2018.10.003 | 30,377,031 | D000222:Adaptation, Physiological; D000900:Anti-Bacterial Agents; D018988:Bacterial Translocation; D018441:Biofilms; D002939:Ciprofloxacin; D003550:Cystic Fibrosis; D006801:Humans; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability; D010641:Phenotype; D011552:Pseudomonas Infections; D011550:Pseudomonas ae... | International journal of medical microbiology : IJMM | 2,018 | D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin |
Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin. | Signal transduction by beta-catenin involves its posttranslational stabilization and import to the nucleus where it interacts with transcription factors. Recent implications for beta-catenin signaling in cancer prompted us to examine colon cancer cell lines for the expression of LEF-1, a transcription factor that binds... | 10.1038/sj.onc.1201462 | 9,419,974 | D000818:Animals; D015820:Cadherins; D002471:Cell Transformation, Neoplastic; D003110:Colonic Neoplasms; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; D006801:Humans; D015151:Immunoblotting; D051821:Lymphoid Enhancer-Binding Factor 1; D008545:Melanoma; D051379:Mice; D009154:Mutation; D016716:PC12 Cells; D... | Oncogene | 1,997 | C495270:CTNNB1 protein, human; C495267:CTNNB1 protein, mouse; D015820:Cadherins; C495268:Ctnnb1 protein, rat; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; C497573:LEF1 protein, human; C497574:Lef1 protein, mouse; C497575:Lef1 protein, rat; D051821:Lymphoid Enhancer-Binding Factor 1; C000715470:MAS1 prot... |
Effect of different sharpening stones on periodontal curettes evaluated by scanning electron microscopy. | The purpose of this study was to evaluate sharpening effect of different sharpening stones on periodontal curettes. In conjunction with 21 brand-new Gracey No. 1/2 curette blades, the Arkansas, India synthetic and ceramic stones were used in this study. The simulated root planing procedure was performed with 45 strokes... | 1,683,373 | D000328:Adult; D003762:Dental Instruments; D005069:Evaluation Studies as Topic; D006801:Humans; D008283:Maintenance; D008855:Microscopy, Electron, Scanning; D016745:Root Planing; D013357:Subgingival Curettage | Journal of the Formosan Medical Association = Taiwan yi zhi | 1,991 | ||
Clear cell sarcoma of the kidney: a clinicopathologic study of 21 patients with long-term follow-up evaluation. | The clinical and pathologic features of 21 children with clear cell sarcoma of the kidney are presented. These cases were identified among 517 primary renal tumors collected from four pediatric institutions. Abdominal mass and hematuria were the usual presenting signs. The male to female ratio was 1.3 to 1. Although th... | 10.1016/s0046-8177(85)80034-4 | 4,065,884 | D000293:Adolescent; D000367:Age Factors; D001859:Bone Neoplasms; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms; D008297:Male; D010281:Parathyroid Hormone; D011453:Prostaglandins; D012509:Sarcoma; D012737:Sex Factors; D013997:... | Human pathology | 1,985 | D010281:Parathyroid Hormone; D011453:Prostaglandins |
Palatogingival groove and root canal instrumentation. | AIM
To evaluate the morphology and impact of root canal preparation in maxillary incisors with palatogingival grooves (PGG).
METHODOLOGY
Twenty extracted human maxillary incisors with PGG were subjected to macroscopic analysis and scanning electron microscopy analysis (SEM). The following characteristics of the PGG w... | 10.1111/iej.13259 | 31,808,951 | D003739:Dental Cementum; D003786:Dental Pulp Cavity; D003804:Dentin; D006801:Humans; D007180:Incisor; D012388:Root Canal Irrigants; D018915:Root Canal Preparation; D012390:Root Canal Therapy; D016369:Smear Layer | International endodontic journal | 2,020 | D012388:Root Canal Irrigants |
Systematic review and meta-analysis of efficacy and safety of hydroxychloroquine and chloroquine in the treatment of COVID-19. | Repurposed drugs like hydroxycloroquine (HCQ) and chloroquine (CQ) are being tested for potential therapeutic role in COVID-19. We aimed to evaluate efficacy and safety of HCQ and CQ in COVID-19. Using PubMed, EMBASE, medRxiv, Google Scholar, clinicaltrials.gov, electronic search was carried out to identify relevant ar... | 10.4103/jfmpc.jfmpc_2338_20 | 34,322,403 | Journal of family medicine and primary care | 2,021 | ||
Prediction of 10-year Overall Survival in Patients with Operable Cervical Cancer using a Probabilistic Neural Network. | Background: Toward the goal of predicting individual long-term cancer survival to guide treatment decisions, this study evaluated the ability of a probabilistic neural network (PNN), an established model used for decision-making in research and clinical settings, to predict the 10-year overall survival in patients with... | 10.7150/jca.33945 | 31,413,737 | Journal of Cancer | 2,019 | ||
[Involvement of lipid peroxidation in regression of heart hypertrophy]. | The regression of hypertrophied heart presupposes disassembling of all cardiomyocyte components including membrane structures. The involvement of free radical oxidation of membrane phospholipids was studied in the cardiac regression. Altitude hypertrophy was developed in barocamera (7000 m, 6 hours daily). 3 weeks of p... | 2,534,472 | D000818:Animals; D002084:Butylated Hydroxytoluene; D006332:Cardiomegaly; D005609:Free Radicals; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation; D008297:Male; D009206:Myocardium; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors | Biulleten' eksperimental'noi biologii i meditsiny | 1,989 | D005609:Free Radicals; D002084:Butylated Hydroxytoluene | |
Family presence during resuscitation: a survey of Canadian critical care nurses' practices and perceptions. | BACKGROUND
The practice of allowing family members to be present at the bedside during cardiopulmonary resuscitation is a controversial one and represents a paradigm shift among health care providers. To date, no research has examined this issue from the perspective of Canadian critical care nurses.
OBJECTIVES
This r... | 18,773,712 | D000328:Adult; D001291:Attitude of Health Personnel; D002170:Canada; D016887:Cardiopulmonary Resuscitation; D003422:Critical Care; D003431:Cross-Cultural Comparison; D005190:Family; D005260:Female; D019983:Guideline Adherence; D017408:Guidelines as Topic; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D... | Dynamics (Pembroke, Ont.) | 2,008 | ||
Homocysteine-specific fluorescence detection and quantification for evaluating S-adenosylhomocysteine hydrolase activity. | Studies have shown that homocysteine (Hcy) levels are closely related to cardiovascular and cerebrovascular diseases. In this work, we have developed and synthesized three copper complexes, F542-Cu2+, F508-Cu2+, and F465-Cu2+ for Hcy detection. The different binding constants (Ks) of the copper complexes endow them wit... | 10.1039/d2an00945e | 35,852,237 | D043383:Adenosylhomocysteinase; D003300:Copper; D003545:Cysteine; D005456:Fluorescent Dyes; D006710:Homocysteine; D061848:Optical Imaging; D011725:Pyridines | The Analyst | 2,022 | D005456:Fluorescent Dyes; D011725:Pyridines; D006710:Homocysteine; D003300:Copper; D043383:Adenosylhomocysteinase; D003545:Cysteine |
The role of complement in UVB-induced inflammation. | To evaluate the role of the complement system in skin inflammation accompanying leukocyte infiltration induced by UVB irradiation, the response of guinea pigs decomplemented with cobra venom factor was compared with that in saline-treated animals. Complement-depleted animals showed a weaker clinical response in the lat... | 2,431,574 | D000818:Animals; D002634:Chemotaxis, Leukocyte; D003167:Complement Activation; D003165:Complement System Proteins; D003872:Dermatitis; D005260:Female; D006168:Guinea Pigs; D007962:Leukocytes; D013997:Time Factors; D014466:Ultraviolet Rays | Acta dermato-venereologica | 1,986 | D003165:Complement System Proteins | |
Cytoarchitecture and fiber connections of the superficial pretectum in a teleost, Navodon modestus. | Fiber connections of the so-called nucleus geniculatus lateralis (or the nucleus pretectalis superficialis pars parvocellularis) in a teleost, Navodon modestus, were examined by means of the horseradish peroxidase (HRP) tracing method. The nucleus receives fibers from the contralateral retina, ipsilateral optic tectum ... | 10.1016/0006-8993(86)90333-1 | 3,719,307 | D000818:Animals; D005399:Fishes; D007031:Hypothalamus; D008636:Mesencephalon; D009900:Optic Nerve; D011903:Raphe Nuclei; D013477:Superior Colliculi; D013687:Telencephalon; D014795:Visual Pathways | Brain research | 1,986 | |
A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells. | Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum. The pathology of cerebral malaria is characterized by the accumulation of infected erythrocytes (IEs) in the microvasculature of the brain caused by parasite adhesins on the surface of IEs binding to human receptors on microvascu... | 10.1073/pnas.1120461109 | 22,619,330 | D000818:Animals; D001921:Brain; D004730:Endothelium, Vascular; D006801:Humans; D008024:Ligands; D010961:Plasmodium; D010963:Plasmodium falciparum; D015800:Protozoan Proteins; D014158:Transcription, Genetic; D059467:Transcriptome; D015854:Up-Regulation | Proceedings of the National Academy of Sciences of the United States of America | 2,012 | D008024:Ligands; D015800:Protozoan Proteins; C085731:erythrocyte membrane protein 1, Plasmodium falciparum |
Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium. | PURPOSE
The aim of this study is to compare implantation and live birth rates (LBR) between fresh euploid embryo transfers versus cryo-all cycles with a subsequent embryo transfer into a prepared endometrium.
MATERIAL AND METHODS
This is a retrospective cohort study. Patients who underwent an IVF cycle with PGS with ... | 10.1007/s10815-016-0647-y | 26,768,140 | D000328:Adult; D000782:Aneuploidy; D001755:Blastocyst; D015331:Cohort Studies; D015925:Cryopreservation; D010064:Embryo Implantation; D004624:Embryo Transfer; D004717:Endometrium; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D019836:Preimplantation Diagnosis... | Journal of assisted reproduction and genetics | 2,016 | |
A role for tele-education in the centralization of accident and emergency services. | We evaluated the use of tele-education to provide an induction programme for accident and emergency senior house officers (SHOs) in three remote locations, and compared their performance with that of SHOs receiving the same induction programme in the conventional manner. Both groups of doctors performed similarly in a ... | 10.1258/135763303322196268 | 12,952,715 | D020375:Education, Distance; D004502:Education, Medical, Continuing; D004635:Emergency Medicine; D004636:Emergency Service, Hospital; D006801:Humans; D008505:Medical Staff, Hospital | Journal of telemedicine and telecare | 2,003 | |
Effect of neoadjuvant chemotherapy on survival in patients with T1 high-grade non-muscle-invasive bladder cancer who underwent radical cystectomy. | Patients with non-muscle-invasive bladder cancer (NMIBC) who are at high and very high risk of disease progression are recommended for radical cystectomy (RC). However, the impact of neoadjuvant chemotherapy (NAC) on survival outcomes in NMIBC patients undergoing RC remains unclear. Patients diagnosed with T1 high-grad... | 10.1097/MD.0000000000034501 | 37,543,821 | D006801:Humans; D015653:Cystectomy; D020360:Neoadjuvant Therapy; D000093284:Non-Muscle Invasive Bladder Neoplasms; D018572:Disease-Free Survival; D053208:Kaplan-Meier Estimate; D001749:Urinary Bladder Neoplasms; D012189:Retrospective Studies | Medicine | 2,023 | |
From cholesterol to consciousness. | The nature of consciousness has been debated for centuries. It can be understood as part and parcel of the natural progression of life from unicellular to multicellular, calcium fluxes mediating communication within and between cells. Consciousness is the vertical integration of calcium fluxes, mediated by the Target o... | 10.1016/j.pbiomolbio.2017.08.009 | 28,830,682 | D000818:Animals; D002450:Cell Communication; D002784:Cholesterol; D003243:Consciousness; D003599:Cytoskeleton; D006801:Humans; D009474:Neurons; D058570:TOR Serine-Threonine Kinases | Progress in biophysics and molecular biology | 2,018 | D002784:Cholesterol; D058570:TOR Serine-Threonine Kinases |
Altered stoichiometry Escherichia coli Cascade complexes with shortened CRISPR RNA spacers are capable of interference and primed adaptation. | The Escherichia coli type I-E CRISPR-Cas system Cascade effector is a multisubunit complex that binds CRISPR RNA (crRNA). Through its 32-nucleotide spacer sequence, Cascade-bound crRNA recognizes protospacers in foreign DNA, causing its destruction during CRISPR interference or acquisition of additional spacers in CRIS... | 10.1093/nar/gkw914 | 27,738,137 | D000222:Adaptation, Physiological; D020029:Base Pairing; D001483:Base Sequence; D001665:Binding Sites; D064113:CRISPR-Cas Systems; D064112:Clustered Regularly Interspaced Short Palindromic Repeats; D004926:Escherichia coli; D015964:Gene Expression Regulation, Bacterial; D034622:RNA Interference; D012329:RNA, Bacterial | Nucleic acids research | 2,016 | D012329:RNA, Bacterial |
Mitochondrial dynamics and its impact on human health and diseases: inside the DRP1 blackbox. | Mitochondria are essential organelles that play a significant role in various cellular processes apart from providing energy in eukaryotic cells. An intricate link between mitochondrial structure and function is now unequivocally accepted. Several molecular players have been identified, which are important in maintaini... | 10.1007/s00109-021-02150-7 | 34,657,190 | D000818:Animals; D034281:Dynamins; D006801:Humans; D063154:Mitochondrial Dynamics; D009154:Mutation; D020033:Protein Isoforms | Journal of molecular medicine (Berlin, Germany) | 2,022 | D020033:Protein Isoforms; C110768:DNM1L protein, human; D034281:Dynamins |
sSLAM: Speeded-Up Visual SLAM Mixing Artificial Markers and Temporary Keypoints. | Environment landmarks are generally employed by visual SLAM (vSLAM) methods in the form of keypoints. However, these landmarks are unstable over time because they belong to areas that tend to change, e.g., shadows or moving objects. To solve this, some other authors have proposed the combination of keypoints and artifi... | 10.3390/s23042210 | 36,850,807 | Sensors (Basel, Switzerland) | 2,023 | ||
Deaf children's speaking, writing, and comprehension of sentences. | Sentence tests of speaking, writing, and comprehension were given to 10M and 10F prelingually deaf Ss (mm HTLs: 91 db, mn age: 12.9 yrs). The hypothesis was confirmed that the older deaf population of school children still has difficulty in writing syntactically correct sentences that they can say. This phenomenon was ... | 7,188,203 | D000293:Adolescent; D002648:Child; D003071:Cognition; D003638:Deafness; D005260:Female; D006236:Handwriting; D006801:Humans; D007805:Language Development Disorders; D007806:Language Disorders; D008037:Linguistics; D008297:Male | The Journal of auditory research | 1,982 | ||
Rapid translocation and insertion of the epithelial Na+ channel in response to RhoA signaling. | Activity of the epithelial Na+ channel (ENaC) is limiting for Na+ absorption across many epithelia. Consequently, ENaC is a central effector impacting systemic blood volume and pressure. Two members of the Ras superfamily of small GTPases, K-Ras and RhoA, activate ENaC. K-Ras activates ENaC via a signaling pathway invo... | 10.1074/jbc.M603716200 | 16,829,523 | D000818:Animals; D016466:CHO Cells; D019556:COS Cells; D002462:Cell Membrane; D002522:Chlorocebus aethiops; D006224:Cricetinae; D053503:Epithelial Sodium Channels; D011905:Genes, ras; D018408:Patch-Clamp Techniques; D019869:Phosphatidylinositol 3-Kinases; D019269:Phosphatidylinositol 4,5-Diphosphate; D017853:Phosphotra... | The Journal of biological chemistry | 2,006 | D053503:Epithelial Sodium Channels; D019269:Phosphatidylinositol 4,5-Diphosphate; D011993:Recombinant Fusion Proteins; D017853:Phosphotransferases (Alcohol Group Acceptor); C020077:1-phosphatidylinositol-4-phosphate 5-kinase; D020741:rho GTP-Binding Proteins; D020742:rhoA GTP-Binding Protein |
The N-terminal SH4 region of the Src family kinase Fyn is modified by methylation and heterogeneous fatty acylation: role in membrane targeting, cell adhesion, and spreading. | The N-terminal SH4 domain of Src family kinases is responsible for promoting membrane binding and plasma membrane targeting. Most Src family kinases contain an N-terminal Met-Gly-Cys consensus sequence that undergoes dual acylation with myristate and palmitate after removal of methionine. Previous studies of Src family... | 10.1074/jbc.M311180200 | 14,660,555 | D000215:Acylation; D000217:Acyltransferases; D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D002448:Cell Adhesion; D002458:Cell Fractionation; D002462:Cell Membrane; D002522:Chlorocebus aethiops; D016384:Consensus Sequence; D005227:Fatty Acids; D049452:Green Fluorescent Proteins; D008164:Luminescent P... | The Journal of biological chemistry | 2,004 | D005227:Fatty Acids; D008164:Luminescent Proteins; D010446:Peptide Fragments; D011518:Proto-Oncogene Proteins; D011993:Recombinant Fusion Proteins; D019814:Myristic Acid; D049452:Green Fluorescent Proteins; D019308:Palmitic Acid; D000217:Acyltransferases; C050480:glycylpeptide N-tetradecanoyltransferase; D051076:Proto-... |
Comparison in the effects of IL-2, IL-12, IL-15 and IFNalpha on gene regulation of granzymes of human NK cell line NK-92. | Serine protease granzymes (GZM) are key effector molecules of granule-mediated cytotoxicity of NK cell, but the requirement for their expression regulation remains largely undefined. In this study, it was showed that IL-2, IL-12, IL-15 and IFNalpha differently regulated the expression of granzymes in NK cells. Although... | 10.1016/j.intimp.2008.03.001 | 18,486,910 | D045744:Cell Line, Tumor; D015971:Gene Expression Regulation, Enzymologic; D053804:Granzymes; D006801:Humans; D016898:Interferon-alpha; D018664:Interleukin-12; D019409:Interleukin-15; D007376:Interleukin-2; D020014:K562 Cells; D007694:Killer Cells, Natural | International immunopharmacology | 2,008 | D016898:Interferon-alpha; D019409:Interleukin-15; D007376:Interleukin-2; D018664:Interleukin-12; D053804:Granzymes |
Multiple pathways regulate Cten in colorectal cancer without a Tensin switch. | CTEN/TNS4 is a member of the Tensin gene family. It localizes to focal adhesions and induces cell motility. The mechanisms regulating Cten expression are unclear although we have shown regulation by Kras in the colon and pancreas. In normal mammary cell lines, it is reportedly upregulated by epidermal growth factor rec... | 10.1111/iep.12154 | 26,852,686 | D002154:Calpain; D015179:Colorectal Neoplasms; D015853:Cysteine Proteinase Inhibitors; D004151:Dipeptides; D004305:Dose-Response Relationship, Drug; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D045325:HCT116 Cells; D006801:H... | International journal of experimental pathology | 2,015 | D015853:Cysteine Proteinase Inhibitors; D004151:Dipeptides; C117307:KRAS protein, human; D008840:Microfilament Proteins; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; C000603370:TNS3 protein, human; C000603371:TNS4 protein, human; D000070876:Tensins; C071482:calpeptin; D004815:Epidermal Growth Facto... |
In vivo and in vitro tools to identify and study transcriptional regulation of USF-1 target genes. | In response to environmental stress, cells trigger a number of molecular mechanisms to control their survival and growth. These include changes in gene expression with corresponding Post-translational modifications to critical transcriptional-control proteins. Transcription is a highly-regulated process that is impacte... | 10.1007/978-1-60761-738-9_21 | 20,694,678 | D045744:Cell Line, Tumor; D004789:Enzyme Activation; D006801:Humans; D008156:Luciferases; D010858:Pigmentation; D011333:Pro-Opiomelanocortin; D044101:Receptors, Melanocortin; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D014158:Transcription, Genetic; D014466:Ultraviolet Rays; D051720:... | Methods in molecular biology (Clifton, N.J.) | 2,010 | D044101:Receptors, Melanocortin; D051720:Upstream Stimulatory Factors; D011333:Pro-Opiomelanocortin; D008156:Luciferases; D048051:p38 Mitogen-Activated Protein Kinases |
Candidal pancreatic abscesses: report of two cases and review. | Pancreatic abscess caused by Candida albicans is very rare. To date, only eight case reports describing a pancreatic abscess caused wholly or in part by Candida species have appeared in the literature. We recently treated two patients with candidal pancreatic abscesses. In our cases as well as those reported in the lit... | 10.1093/clinids/14.4.884 | 1,576,283 | D000038:Abscess; D000328:Adult; D002176:Candida albicans; D002177:Candidiasis; D017024:Chemotherapy, Adjuvant; D003646:Debridement; D004322:Drainage; D005260:Female; D006801:Humans; D010182:Pancreatic Diseases | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | 1,992 | |
Role of the microtubular system in platelet aggregation. | 1. Four structural systems are involved in the process of platelet activation that leads to aggregation: 1) the membrane system, i.e., the cytoplasmic membrane, the dense tubular structure and the open canalicular structure; 2) alpha and dense granules; 3) the peripheral microtubular coils; 4) the microfibrillar meshwo... | 7,874,021 | D001792:Blood Platelets; D002927:Cimetidine; D003078:Colchicine; D003208:Concanavalin A; D003571:Cytochalasin B; D015638:Cytochalasin D; D006801:Humans; D008870:Microtubules; D010974:Platelet Aggregation; D013755:Tetradecanoylphorbol Acetate; D013988:Ticlopidine; D014747:Vinblastine | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas | 1,994 | D003208:Concanavalin A; D015638:Cytochalasin D; D003571:Cytochalasin B; D014747:Vinblastine; D002927:Cimetidine; D013755:Tetradecanoylphorbol Acetate; D013988:Ticlopidine; D003078:Colchicine | |
14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity. | Regulator of G protein signaling (RGS) proteins function as GTPase-activating proteins (GAPs) that stimulate the inactivation of heterotrimeric G proteins. We have recently shown that RGS proteins may be regulated on a post-translational level (Benzing, T., Brandes, R., Sellin, L., Schermer, B., Lecker, S., Walz, G., a... | 10.1074/jbc.M002905200 | 10,862,767 | D048948:14-3-3 Proteins; D000595:Amino Acid Sequence; D001665:Binding Sites; D002460:Cell Line; D019204:GTP-Binding Proteins; D020690:GTPase-Activating Proteins; D006801:Humans; D007700:Kinetics; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D016297:Mutagenesis, Site-Directed; D010766:Phosphorylati... | The Journal of biological chemistry | 2,000 | D048948:14-3-3 Proteins; D020690:GTPase-Activating Proteins; D011506:Proteins; D020710:RGS Proteins; C485898:RGS3 protein, human; C492039:RGS7 protein, human; D011994:Recombinant Proteins; D012097:Repressor Proteins; C415085:Rgs3 protein, mouse; C437714:Rgs3 protein, rat; C492038:Rgs7 protein, mouse; D014446:Tyrosine 3... |
Stat3 and Stat4: members of the family of signal transducers and activators of transcription. | The deduced amino acid sequence of two members of the signal transducers and activators of transcription (STAT) family from the mouse are described. Comparison with the deduced protein sequence of the two previously described genes (Stat91 and Stat113), discovered because of their activation as transcription factors af... | 10.1073/pnas.91.11.4806 | 7,545,930 | D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D017124:Conserved Sequence; D004247:DNA; D004268:DNA-Binding Proteins; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D012333:RNA, Messenger; D050796:STAT3 Transcription Factor; D050797:ST... | Proceedings of the National Academy of Sciences of the United States of America | 1,994 | D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D050797:STAT4 Transcription Factor; C494090:STAT4 protein, human; C494087:Stat3 protein, mouse; C494091:Stat4 protein, mouse; D015534:Trans-Activators; D014157:Transcription Factors; D004247:DNA |
Occasional males in parthenogenetic populations of Asobara japonica (Hymenoptera: Braconidae): low Wolbachia titer or incomplete coadaptation? | Wolbachia are endosymbiotic bacteria known to manipulate the reproduction of their hosts. Some populations of the parasitoid wasp Asobara japonica are infected with Wolbachia and reproduce parthenogenetically, while other populations are not infected and reproduce sexually. Wolbachia-infected A. japonica females regula... | 10.1038/hdy.2011.82 | 21,934,703 | D000818:Animals; D004272:DNA, Mitochondrial; D005260:Female; D006239:Haplotypes; D054884:Host-Pathogen Interactions; D006927:Hymenoptera; D008297:Male; D008969:Molecular Sequence Data; D010312:Parthenogenesis; D012098:Reproduction; D012744:Sex Ratio; D013559:Symbiosis; D013696:Temperature; D020577:Wolbachia | Heredity | 2,012 | D004272:DNA, Mitochondrial |
Long-term effects of a brief distraction intervention on children's laboratory pain reactivity. | This 2-year follow-up study examined the effects of a brief behavioral intervention on task-based coping and pain reactivity to the cold pressor task (CPT). In the original study by Fanurik et al. (1993), 64 children (aged 8 to 10) whose coping style was categorized as "attender" or "distracter," based on primary copin... | 10.1177/0145445503251583 | 12,705,106 | D000223:Adaptation, Psychological; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010146:Pain; D059408:Pain Management; D010147:Pain Measurement; D011897:Random Allocation; D013995:Time; D013997:Time Factors | Behavior modification | 2,003 | |
Immediate and perioperative outcomes of polypropylene mesh in pelvic floor repair in a predominantly obese population. | This retrospective study was to identify perioperative and postoperative complications associated with use of polypropylene mesh for pelvic floor repair in a UK district general hospital in a predominantly obese population. The sample size was 27 women with data retrieved from records. Total mesh was used in 37.1%, iso... | 21,355,454 | D000368:Aged; D015992:Body Mass Index; D004868:Equipment Failure; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D008875:Middle Aged; D056128:Obesity, Abdominal; D050177:Overweight; D011126:Polypropylenes; D011183:Postoperative Complications; D012008:Recurrence; D013526:Surgical Mesh; D016896:Tre... | Clinical and experimental obstetrics & gynecology | 2,010 | D011126:Polypropylenes | |
Use of C-reactive protein for the early prediction of anastomotic leak after esophagectomy: Systematic review and Bayesian meta-analysis. | BACKGROUND
Early suspicion, diagnosis, and timely treatment of anastomotic leak after esophagectomy is essential. Retrospective studies have investigated the role of C-reactive protein (CRP) as early marker of anastomotic leakage. The aim of this systematic review and meta-analysis was to evaluate the predictive value ... | 10.1371/journal.pone.0209272 | 30,557,392 | D057868:Anastomotic Leak; D001499:Bayes Theorem; D015415:Biomarkers; D002097:C-Reactive Protein; D016629:Esophagectomy; D006801:Humans; D011183:Postoperative Complications | PloS one | 2,018 | D015415:Biomarkers; D002097:C-Reactive Protein |
The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. | Saccharomyces cerevisiae CTDK-I is a protein kinase complex that specifically and efficiently hyperphosphorylates the carboxyl-terminal repeat domain (CTD) of RNA polymerase II and is composed of three subunits of 58, 38, and 32 kDa. The kinase is essential in vivo for normal phosphorylation of the CTD and for normal g... | 10.1128/MCB.15.10.5716 | 7,565,723 | D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D003080:Cold Temperature; D018844:Cyclin-Dependent Kinases; D016213:Cyclins; D005800:Genes, Fungal; D008969:Molecular Sequence Data; D009154:Mutation; D011494:Protein Kinases; D015183:Restriction Mapping; D012441:Saccharomyces cerevisiae; D... | Molecular and cellular biology | 1,995 | D016213:Cyclins; D011494:Protein Kinases; C060137:carboxy-terminal domain kinase; D018844:Cyclin-Dependent Kinases |
Deletion 1p in a low-grade chondrosarcoma in a patient with Ollier disease. | Ollier disease is an uncommon, nonhereditary developmental disorder affecting enchondral ossification. Cytogenetic analysis of low-grade chondrosarcoma in a patient with Ollier disease (multiple enchondromatosis) revealed an interstitial deletion, del(1)(p11p31.2), as the only chromosome abnormality. This is the first ... | 10.1016/s0165-4608(98)00027-2 | 9,723,029 | D000328:Adult; D002356:Cartilage; D002813:Chondrosarcoma; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D004687:Enchondromatosis; D006801:Humans; D008297:Male; D012540:Scapula | Cancer genetics and cytogenetics | 1,998 | |
Dual inhibition of BCL2L1 and MCL1 is highly effective against RET fusion-positive or MET exon 14 skipping mutation-positive lung adenocarcinoma cells. | Non-small cell lung carcinomas (NSCLCs), especially lung adenocarcinomas (LUADs), harbor several driver mutations against which highly effective tyrosine kinase inhibitors (TKIs) are available. Although TKIs are generally effective against certain NSCLCs, primary or acquired resistance almost always develops. Driver mu... | 10.1016/j.bbrc.2022.09.039 | 36,126,466 | D000230:Adenocarcinoma; D000077192:Adenocarcinoma of Lung; D002289:Carcinoma, Non-Small-Cell Lung; D005091:Exons; D006801:Humans; D008175:Lung Neoplasms; D009154:Mutation; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D047428:Protein Kinase Inhibitors; D051096:Proto-Oncogene Proteins c-ret; D012333:RNA, Messenger; ... | Biochemical and biophysical research communications | 2,022 | C494811:BCL2L1 protein, human; C579095:MCL1 protein, human; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D047428:Protein Kinase Inhibitors; D012333:RNA, Messenger; D051020:bcl-X Protein; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human |
Perceived organizational culture and its relationship with job satisfaction in primary hospitals of Jimma zone and Jimma town administration, correlational study. | BACKGROUND
The concept of Organizational Culture (OC) which refers to the pattern of values, norms, beliefs, attitudes and assumptions may not be articulated through verbal language. However, it shapes the way people behave and the way things get done in an organization. The management of organizational culture is incr... | 10.1186/s12913-020-05319-x | 32,429,882 | D000328:Adult; D001291:Attitude of Health Personnel; D003430:Cross-Sectional Studies; D005002:Ethiopia; D005260:Female; D006282:Health Personnel; D006739:Hospital Administration; D006761:Hospitals; D006801:Humans; D007588:Job Satisfaction; D008297:Male; D015279:Organizational Culture; D012044:Regression Analysis; D0117... | BMC health services research | 2,020 | |
Integrated molecular and behavioural data reveal deep circadian disruption in response to artificial light at night in male Great tits (Parus major). | Globally increasing levels of artificial light at night (ALAN) are associated with shifting rhythms of behaviour in many wild species. However, it is unclear whether changes in behavioural timing are paralleled by consistent shifts in the molecular clock and its associated physiological pathways. Inconsistent shifts be... | 10.1038/s41598-022-05059-4 | 35,091,579 | D000090465:Light Pollution | Scientific reports | 2,022 | |
Invasive glioma cells: The malignant pioneers that follow the current. | Glioblastoma is a lethal, diffusely invasive brain cancer that is robustly regulated by the activity of the brain itself, in part through neuron-to-glioma synaptic communication. Venkataramani et al. have conceptually advanced understanding of glioblastoma interactions with neural circuits, demonstrating that conductio... | 10.1016/j.cell.2022.06.033 | 35,931,016 | D001932:Brain Neoplasms; D045744:Cell Line, Tumor; D005909:Glioblastoma; D005910:Glioma; D006801:Humans; D009361:Neoplasm Invasiveness; D009474:Neurons | Cell | 2,022 | |
The role of autobiographical memory specificity in deliberate self-harm: correlates and consequences. | BACKGROUND
Several studies have identified reduced specificity of autobiographical memory in deliberate self-harm (DSH) patients. However it is not clear which clinical variables are associated with low memory specificity in this group, or whether low specificity is particularly associated with recent DSH.
METHOD
68 ... | 10.1016/j.jad.2006.12.006 | 17,258,815 | D000328:Adult; D001325:Autobiographies as Topic; D002648:Child; D002650:Child Abuse, Sexual; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D033182:Intention; D008297:Male; D008568:Memory; D019964:Mood Disorders; D011581:Psychological Tests; D016728:Self-Injurious Behavior; D013406:S... | Journal of affective disorders | 2,007 | |
Random Forest Model for Labor Induction in Pregnant Women With Hypertensive Disorders Using a Cervical Double Balloon. | Context
Women with hypertensive disorders of pregnancy often need to have labor induced. The use of cervical double balloons to trigger cervical ripening, combined with the use of oxytocin, has been widely used for labor induction in recent years. In the evaluation of factors affecting the success rate of labor inducti... | 36,302,236 | D002648:Child; D011247:Pregnancy; D005260:Female; D006801:Humans; D010121:Oxytocin; D037841:Pregnant Women; D012189:Retrospective Studies; D046110:Hypertension, Pregnancy-Induced; D000093743:Random Forest; D010920:Placenta; D007751:Labor, Induced; D020070:Cervical Ripening | Alternative therapies in health and medicine | 2,023 | D010121:Oxytocin | |
Fontan procedure: old lessons and new frontiers. | The Fontan procedure is an operation created for patients with single ventricular physiology. These patients have the potential to survive well into adulthood, however new problems can arise. Various topics, including physiological constraints, patient care, morbidity and clinical outcomes are discussed. The aim of thi... | 10.1586/14779072.4.4.515 | 16,918,270 | D001145:Arrhythmias, Cardiac; D001991:Bronchitis; D018729:Fontan Procedure; D018610:Heart Bypass, Right; D006333:Heart Failure; D016027:Heart Transplantation; D006801:Humans; D018579:Patient Selection; D011504:Protein-Losing Enteropathies; D016896:Treatment Outcome | Expert review of cardiovascular therapy | 2,006 | |
Current Insights into Immunotherapy Approaches for Food Allergy. | In the last decade, there has been increasing research dedicated to food immunotherapy to induce clinical desensitization and provide protection by increasing clinical reaction thresholds. Results from recent food immunotherapy studies with differing routes of administration (oral, sublingual, and epicutaneous) suggest... | 10.2147/ITT.S266257 | 33,537,245 | ImmunoTargets and therapy | 2,021 | ||
Labeling of mitochondrial proteins in living cells by the thiol probe thiobutyltriphenylphosphonium bromide. | Alterations to the redox state of mitochondrial thiols is a particularly important response to oxidative stress, because mitochondria are a major source of reactive oxygen species within cells. To investigate these changes we designed and synthesized a novel probe for mitochondrial thiols, thiobutyltriphenylphosphonium... | 10.1006/abbi.1996.9861 | 9,056,230 | D000818:Animals; D000975:Antioxidants; D003600:Cytosol; D005260:Female; D008930:Mitochondria, Liver; D009943:Organophosphorus Compounds; D010084:Oxidation-Reduction; D011506:Proteins; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological; D013438:Sulfhydryl Compounds; D013439:Sulfhydryl Reagents | Archives of biochemistry and biophysics | 1,997 | D000975:Antioxidants; D009943:Organophosphorus Compounds; D011506:Proteins; D013438:Sulfhydryl Compounds; D013439:Sulfhydryl Reagents; C095693:thiobutyltriphenylphosphonium |
Trends in Medicare reimbursement for neurosurgical procedures: 2000 to 2018. | OBJECTIVE
There is currently a paucity of literature evaluating procedural reimbursements and financial trends in neurosurgery. A comprehensive understanding of the economic trends and financial health of neurosurgery is important to ensure the sustained success and growth of the specialty moving forward. The purpose o... | 30,717,049 | D016208:Databases, Factual; D006801:Humans; D007349:Insurance, Health, Reimbursement; D006278:Medicare; D019635:Neurosurgical Procedures; D058996:Quality Improvement; D014481:United States | Journal of neurosurgery | 2,019 | ||
Adenylyl cyclase mRNA expression does not reflect the predominant Ca2+/calmodulin-stimulated activity in the hypothalamus. | Only three (Types I, II, V) of the six currently-described subtypes of adenylyl cyclase are prominently expressed in the rat brain. These species are differently sensitive to Ca2+, beta gamma subunits of G-proteins and protein kinase C. A knowledge of the susceptibility of the cAMP-signalling system in particular brain... | 10.1111/j.1365-2826.1994.tb00633.x | 7,894,469 | D000262:Adenylyl Cyclases; D000818:Animals; D002118:Calcium; D002147:Calmodulin; D015870:Gene Expression; D007031:Hypothalamus; D007032:Hypothalamus, Anterior; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus; D012333:RNA, Messenger; D051381:Rats; D017207:Rats, Sprague-Dawley; D013495:Supraoptic Nucleus; D014... | Journal of neuroendocrinology | 1,994 | D002147:Calmodulin; D012333:RNA, Messenger; D000262:Adenylyl Cyclases; D002118:Calcium |
Malignant schwannoma of the stomach in a patient with neurofibromatosis. | Malignant schwannoma of the stomach is a rare neurogenic tumor. We report a case in a man with neurofibromatosis, who developed liver metastasis 1 year after excision of the tumor and died a few months later despite aggressive chemotherapy. | 3,131,156 | D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D009442:Neurilemmoma; D009456:Neurofibromatosis 1; D013274:Stomach Neoplasms | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology | 1,988 | ||
Aging in a Bakongo culture. | The Bakongo tribe resides in Lower Zaire, the southern part of Congo-Brazzaville and the northern part of Angola. The term mbuta (plural is bambuta) means "old" or "older than oneself." It is a term of respect. The aging intervene in all the important life situations: marriage, witchcraft, magic, native palavers, etc. ... | 10.2190/6HAK-6YPM-A680-69K1 | 7,216,517 | D000368:Aged; D000375:Aging; D003469:Culture; D015023:Democratic Republic of the Congo; D004644:Emotions; D005260:Female; D006801:Humans; D008273:Magic; D008297:Male; D010684:Philosophy; D011587:Psychology, Comparative; D012067:Religion; D012380:Role | International journal of aging & human development | 1,980 | |
Unusual presentations of nonmycotic hepatic artery pseudoaneurysms after liver transplantation. | The clinical presentation and causes of hepatic artery pseudoaneurysm vary widely in the postoperative liver transplant recipient, although infection is the most common cause. Although uncommon, hepatic artery complications continue to be an important source of morbidity in liver transplant recipients. Thrombosis, sten... | 10.1002/lt.500050306 | 10,226,110 | D000328:Adult; D017541:Aneurysm, False; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies | Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society | 1,999 | |
An automated system for the measurement of alanine/EPR dosimeters | NPL for several years has offered mailed reference dosimetry services based on alanine/EPR dosimeters, both at industrial and therapy dose levels. Compared to other methods of reference dosimetry, operator involvement in alanine/EPR has been found to be relatively high, and contributes significantly to the overall econ... | 10.1016/s0969-8043(00)00068-3 | 10,836,427 | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine | 2,000 | ||
Rare variant of total anomalous pulmonary venous connection: intrapulmonary drainage of one lung by the other--a case report and review of the literature. | Total anomalous pulmonary venous connection is an uncommon congenital cardiovascular anomaly but one that occurs frequently in the asplenia syndrome. We present a rare type of total anomalous pulmonary venous connection in a 4-month-old baby with the asplenia syndrome. In this patient, all of the left pulmonary veins u... | 9,050,067 | D014644:Genetic Variation; D006801:Humans; D007223:Infant; D008297:Male; D011652:Pulmonary Circulation; D011667:Pulmonary Veins | Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association | 1,997 | ||
Saltatory control of isometric growth in the zebrafish caudal fin is disrupted in long fin and rapunzel mutants. | Zebrafish fins grow by sequentially adding new segments of bone to the distal end of each fin ray. In wild type zebrafish, segment addition is regulated such that an isometric relationship is maintained between fin length and body length over the lifespan of the growing fish. Using a novel, surrogate marker for fin gro... | 10.1016/s0012-1606(03)00186-6 | 12,871,703 | D000375:Aging; D000818:Animals; D015415:Biomarkers; D001824:Body Constitution; D001827:Body Height; D019521:Body Patterning; D002455:Cell Division; D005121:Extremities; D008954:Models, Biological; D009154:Mutation; D010641:Phenotype; D015027:Zebrafish | Developmental biology | 2,003 | D015415:Biomarkers |
Suicide gene therapy using adenovirus vector for human oral squamous carcinoma cell line in vitro. | Recently, suicide gene therapy using the herpes simplex virus thymidine kinase (HSVtk) gene followed by ganciclovir (GCV) administration was evaluated for the treatment of cancer. The purpose of this study was to investigate the effectiveness of suicide gene therapy using the replication-deficient recombinant adenoviru... | 17,375,474 | D000256:Adenoviridae; D000998:Antiviral Agents; D002294:Carcinoma, Squamous Cell; D045744:Cell Line, Tumor; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D015774:Ganciclovir; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D008048:Lip Neoplasms; D018139:Simplexvirus; D013937:Thymidi... | Nagoya journal of medical science | 2,005 | D000998:Antiviral Agents; D013937:Thymidine Kinase; D015774:Ganciclovir | |
Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages. | Syntaxin 11 (Stx11) is a SNARE protein enriched in cells of the immune system. Loss or mutation of Stx11 results in familial hemophagocytic lymphohistiocytosis type-4 (FHL-4), an autosomal recessive disorder of immune dysregulation characterized by high levels of inflammatory cytokines along with defects in T-cell and ... | 10.1111/j.1600-0854.2011.01189.x | 21,388,490 | D000818:Animals; D002460:Cell Line; D011992:Endosomes; D006801:Humans; D052118:Lysosomal-Associated Membrane Protein 1; D008247:Lysosomes; D008264:Macrophages; D051379:Mice; D011485:Protein Binding; D050765:Qa-SNARE Proteins; D050766:Qb-SNARE Proteins; D011993:Recombinant Fusion Proteins; D050600:SNARE Proteins | Traffic (Copenhagen, Denmark) | 2,011 | D052118:Lysosomal-Associated Membrane Protein 1; D050765:Qa-SNARE Proteins; D050766:Qb-SNARE Proteins; D011993:Recombinant Fusion Proteins; D050600:SNARE Proteins; C491416:VTI1B protein, human |
Analysis and critical review of the development of bioethics in Belarus. | The main trends of the bioethics development in Belarus have been analyzed on the basis of the materials collected by the Ethics Documentation Center (ISEU, Minsk, Belarus). A critical review of the most important publications in the field since 2000 suggests that development of bioethics in Belarus has occurred in two... | 10.1007/s11019-012-9415-7 | 22,644,503 | D026688:Bioethical Issues; D001675:Bioethics; D035843:Biomedical Research; D002986:Clinical Trials as Topic; D003695:Delivery of Health Care; D004992:Ethics, Medical; D005610:Freedom; D006801:Humans; D026706:Paternalism; D011056:Political Systems; D011057:Politics; D002094:Republic of Belarus; D012945:Social Values | Medicine, health care, and philosophy | 2,012 | |
Does cholecystectomy affect antral mucosa? Endoscopic, histopathologic and DNA flow cytometric study. | BACKGROUND/AIMS
Although cholecystectomy is still the "gold standard" for treatment of gallstones, this operation may be followed by gastric disorders. The aim of this study is to detect the effects of cholecystectomy on gastric antral mucosa.
METHODOLOGY
This prospective study has been carried out on 46 patients (20... | 10,918,999 | D002763:Cholecystectomy; D016099:Endoscopy, Gastrointestinal; D005434:Flow Cytometry; D005753:Gastric Mucosa; D005756:Gastritis; D006801:Humans; D011003:Ploidies; D011446:Prospective Studies; D011706:Pyloric Antrum | Hepato-gastroenterology | 2,000 | ||
Facial palsy in multiple sclerosis. | Facial palsy occurred in 21 (19.6%) of 107 Japanese patients with multiple sclerosis (MS) during a mean follow-up period of 4.3 years. We observed residual signs of facial palsy in five other patients in whom acute onset was confirmed from medical records. Facial palsy began on average 7.6 years after the onset of MS b... | 10.1007/s004150050158 | 9,402,539 | D000328:Adult; D017668:Age of Onset; D005158:Facial Paralysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007564:Japan; D008297:Male; D009103:Multiple Sclerosis | Journal of neurology | 1,997 | |
Functional coupling of the NK1 tachykinin receptor to phospholipase D in chinese hamster ovary cells and astrocytoma cells. | In [3H]myristic acid-prelabeled Chinese hamster ovary cells stably expressing the rat NK1 tachykinin receptor, the selective NK1 agonist [Pro9]substance P ([Pro9]SP) time and concentration dependently stimulated the formation of [3H]phosphatidylethanol in the presence of ethanol. This [Pro9]SP-induced activation of pho... | 10.1046/j.1471-4159.1998.70052091.x | 9,572,295 | D000818:Animals; D001254:Astrocytoma; D016466:CHO Cells; D002118:Calcium; D006224:Cricetinae; D000242:Cyclic AMP; D004789:Enzyme Activation; D019204:GTP-Binding Proteins; D020404:Glycerophospholipids; D006801:Humans; D019814:Myristic Acid; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D010739:Phospholipase ... | Journal of neurochemistry | 1,998 | D020404:Glycerophospholipids; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D018040:Receptors, Neurokinin-1; D015320:Tachykinins; C051521:phosphatidylethanol; D019814:Myristic Acid; C067285:substance P, Pro(9)-; D013373:Substance P; D000242:Cyclic AMP; D011493:Protein Kinase C; D010739:Phospholipase D; D019... |
DNA metalating-intercalating hybrid agents for the treatment of chemoresistant cancers. | Nonclassical platinum-based antitumor agents have shown enormous potential in the treatment of chemoresistant cancers. The design of these agents is based on the hypothesis that platinum-containing pharmacophores that react with nuclear DNA in cancer cells radically differently than the clinical agent cisplatin will pr... | 10.1002/chem.201202050 | 22,987,397 | D000166:Acridines; D000970:Antineoplastic Agents; D002945:Cisplatin; D004247:DNA; D018736:DNA Adducts; D019008:Drug Resistance, Neoplasm; D006801:Humans; D006860:Hydrogen Bonding; D007364:Intercalating Agents; D007700:Kinetics; D008175:Lung Neoplasms; D008958:Models, Molecular; D015394:Molecular Structure; D009944:Orga... | Chemistry (Weinheim an der Bergstrasse, Germany) | 2,012 | D000166:Acridines; D000970:Antineoplastic Agents; D018736:DNA Adducts; D007364:Intercalating Agents; D009944:Organoplatinum Compounds; D004247:DNA; D002945:Cisplatin |
Grower adoption of insecticide resistance management practices increase with extension-based program. | BACKGROUND
Insecticide resistance management (IRM) practices that improve the sustainability of agricultural production systems are developed, but few studies address the challenges with their implementation and success rates of adoption. This study examined the effectiveness of a voluntary, extension-based program to ... | 10.1002/ps.5150 | 30,047,237 | D000818:Animals; D000069601:Crop Protection; D007300:Insect Control; D007305:Insecticide Resistance; D007306:Insecticides; D009518:New York; D019697:Onions; D061149:Thysanoptera | Pest management science | 2,019 | D007306:Insecticides |
Effects of dietary antioxidants and environmental stressors on immune function and condition in Lithobates (Rana) sylvaticus. | The negative effects of abiotic and biotic stressors on animal condition, physiology, behaviour, and fitness have become increasingly recognized, making it critical to understand how these may be mitigated, such as through diet. When consumed, dietary antioxidants (secondary metabolites produced by plants) provide prot... | 10.1016/j.cbpa.2018.11.017 | 30,502,473 | D000818:Animals; D000975:Antioxidants; D001280:Atrazine; D004032:Diet; D004781:Environmental Exposure; D006373:Helminthiasis; D006540:Herbicides; D007814:Larva; D018384:Oxidative Stress; D011898:Ranidae | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology | 2,019 | D000975:Antioxidants; D006540:Herbicides; D001280:Atrazine |
Factors affecting use of personal protective equipment and pesticide safety practices: A systematic review. | An evidence-based understanding of factors influencing PPE use and pesticide safety practices has the benefit of facilitating the design of interventions to minimize exposure to pesticides and the promotion of the utilization of PPE and safety practices among agricultural pesticide handlers. The aim of this study, ther... | 10.1016/j.envres.2020.109444 | 32,247,154 | D000383:Agriculture; D000067565:Farmers; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D016273:Occupational Exposure; D000067393:Personal Protective Equipment; D010575:Pesticides; D012449:Safety | Environmental research | 2,020 | D010575:Pesticides |
Celiac disease and selected long-term health issues. | Celiac disease is a genetically-based and immunologically-mediated systemic disorder, affecting primarily the small intestine in adults. About 0.5-1% of most populations studied are affected, with up to 2% in Finland. In families, specifically first-degree relatives, up to 20% may have the disease. Despite increased aw... | 22,940,076 | D001706:Biopsy; D002446:Celiac Disease; D055050:Diet, Gluten-Free; D006262:Health; D006801:Humans; D007239:Infections; D007410:Intestinal Diseases; D007421:Intestine, Small; D008223:Lymphoma; D010349:Patient Compliance; D012008:Recurrence | Maturitas | 2,012 | ||
On the Optimization of a Centrifugal Maglev Blood Pump Through Design Variations. | Centrifugal blood pumps are usually designed with secondary flow paths to avoid flow dead zones and reduce the risk of thrombosis. Due to the secondary flow path, the intensity of secondary flows and turbulence in centrifugal blood pumps is generally very high. Conventional design theory is no longer applicable to cent... | 10.3389/fphys.2021.699891 | 34,220,556 | Frontiers in physiology | 2,021 | ||
A Burkholderia pseudomallei deltapurM mutant is avirulent in immunocompetent and immunodeficient animals: candidate strain for exclusion from select-agent lists. | Burkholderia pseudomallei causes the disease melioidosis in humans and is classified as a category B select agent. Research utilizing this pathogen is highly regulated in the United States, and even basic studies must be conducted in biosafety level 3 (BSL-3) facilities. There is currently no attenuated B. pseudomallei... | 10.1128/IAI.01313-09 | 20,404,077 | D000818:Animals; D016957:Burkholderia pseudomallei; D006224:Cricetinae; D005260:Female; D017353:Gene Deletion; D005798:Genes, Bacterial; D008099:Liver; D008168:Lung; D008554:Melioidosis; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D016296:Mutagenesis; D013154:Spleen | Infection and immunity | 2,010 | |
Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry. | Hepatocellular carcinoma (HCC) usually afflicts individuals in their maturity after a protracted liver disease. Contrasting with this pattern, the age structure of HCC in Andean people displays a bimodal distribution with half of the patients developing HCC in adolescence and early adulthood. To deepen our understandin... | 10.18632/oncotarget.27890 | 33,747,361 | Oncotarget | 2,021 | ||
Xenogeneic fibroblasts inhibit the growth of the breast and ovarian cancer cell lines in co-culture. | Cell-based therapies cure some hematologic malignancies, although little information exists on solid cancer cell responses. The study objective was to test the hypothesis that xenogeneic fibroblasts can inhibit the growth of human cancer cell lines in vitro. Seven human cell lines (pancreatic cancer HPAF II; brain canc... | 34,734,528 | D000818:Animals; D017209:Apoptosis; D001943:Breast Neoplasms; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002522:Chlorocebus aethiops; D018920:Coculture Techniques; D005260:Female; D005347:Fibroblasts; D006801:Humans; D010051:Ovarian Neoplasms | Neoplasma | 2,021 | ||
Structure and function of rice hybrid genomes reveal genetic basis and optimal performance of heterosis. | Exploitation of crop heterosis is crucial for increasing global agriculture production. However, the quantitative genomic analysis of heterosis was lacking, and there is currently no effective prediction tool to optimize cross-combinations. Here 2,839 rice hybrid cultivars and 9,839 segregation individuals were reseque... | 10.1038/s41588-023-01495-8 | 37,679,493 | D006801:Humans; D006823:Hybrid Vigor; D012275:Oryza; D000069600:Plant Breeding; D010641:Phenotype; D000483:Alleles | Nature genetics | 2,023 | |
Glucose-6-phosphate modification of bovine renal Na,K-ATPase: a model for changes occurring in the human renal medulla in diabetes. | The kinetics of hydrolysis of ATP were determined for the renal Na,K-ATPase, in the K+ conformation, modified with glucose-6-phosphate. There was a shift in the ATP hydrolysis kinetics from negative kinetic co-operativity for the control enzyme preparations to substrate inhibition kinetics for the modified enzyme prepa... | 10.1016/0006-291x(85)90219-0 | 2,996,541 | D000255:Adenosine Triphosphate; D000818:Animals; D002417:Cattle; D003920:Diabetes Mellitus; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates; D006801:Humans; D006868:Hydrolysis; D066298:In Vitro Techniques; D007679:Kidney Medulla; D007700:Kinetics; D008433:Mathematics; D011487:Protein Conformation; D000254:Sodium... | Biochemical and biophysical research communications | 1,985 | D005958:Glucosephosphates; D019298:Glucose-6-Phosphate; D000255:Adenosine Triphosphate; D000254:Sodium-Potassium-Exchanging ATPase |
Functional glyco-metagenomics elucidates the role of glycan-related genes in environments. | BACKGROUND
Glycan-related genes play a fundamental role in various processes for energy acquisition and homeostasis maintenance while adapting to the environment in which the organism exists; however, their role in the microbiome in the environment is unclear.
METHODS
Sequence alignment was performed between known gl... | 10.1186/s12859-021-04425-9 | 34,663,219 | D000222:Adaptation, Physiological; D006026:Glycoside Hydrolases; D006801:Humans; D054892:Metagenome; D056186:Metagenomics; D011134:Polysaccharides | BMC bioinformatics | 2,021 | D011134:Polysaccharides; D006026:Glycoside Hydrolases |
Cell electrophoresis for diagnostic purposes. I. Diagnostic value of the electrophoretic mobility test (EMT) for the detection of gynaecological malignancies. | Lymphocytes from 278 gynaecological patients (100 controls and 178 patients with a malignant condition) have been investigated for their response to encephalitogenic factor, cancer basic protein, and KCl extract of adenocarcinoma of the body of the uterus as "antigens", using tanned sheep erythrocytes ETS as indicator ... | 10.1038/bjc.1981.88 | 6,166,306 | D000230:Adenocarcinoma; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm; D004586:Electrophoresis; D005260:Female; D005833:Genital Neoplasms, Female; D006801:Humans; D008214:Lymphocytes; D008875:Middle Aged; D004676:Myelin Basic Protein; D009363:Neoplasm Proteins; D014594:Uterine Neoplasms | British journal of cancer | 1,981 | D000951:Antigens, Neoplasm; D004676:Myelin Basic Protein; D009363:Neoplasm Proteins |
Review on the Degradation Mechanisms of Metal-N-C Catalysts for the Oxygen Reduction Reaction in Acid Electrolyte: Current Understanding and Mitigation Approaches. | One bottleneck hampering the widespread use of fuel cell vehicles, in particular of proton exchange membrane fuel cells (PEMFCs), is the high cost of the cathode where the oxygen reduction reaction (ORR) occurs, due to the current need of precious metals to catalyze this reaction. Electrochemists tackle this issue in t... | 10.1021/acs.chemrev.2c00685 | 37,432,676 | Chemical reviews | 2,023 | ||
Anglicization of hospital information systems: Managing diversity alongside particularity. | CONTEXT
Despite widespread efforts to improve the quality and safety of healthcare through use of hospital information systems (HIS), many healthcare organizations face challenges in implementation and effective use of these applications, in particular when systems have been developed internationally (mainly in the US)... | 10.1016/j.ijmedinf.2018.09.014 | 30,342,691 | D002755:Choice Behavior; D003625:Data Collection; D055695:Electronic Prescribing; D004739:England; D006751:Hospital Information Systems; D006801:Humans; D036301:Qualitative Research | International journal of medical informatics | 2,018 | |
Validation of the G.LAB MD2680 digital automatic blood pressure monitor according to international protocols. | OBJECTIVE
The aim of this study was to validate the G.LAB MD2680 digital automatic blood pressure (BP) monitor according to major international protocols.
PARTICIPANTS AND METHODS
The device was evaluated against auscultatory sphygmomanometry according to the European Society of Hypertension International Protocol (E... | 10.1097/MBP.0000000000000254 | 28,288,006 | D000368:Aged; D000369:Aged, 80 and over; D001795:Blood Pressure Determination; D015924:Blood Pressure Monitors; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic | Blood pressure monitoring | 2,017 | |
Field studies on equine influenza vaccination regimes in thoroughbred foals and yearlings. | The purpose of these studies was to examine the response of Thoroughbred foals and yearlings to different influenza vaccines and vaccination regimes. The horses' antibody levels against haemagglutinin, an established correlate of protection were measured by haemagglutination inhibition. The first study investigated the... | 10.1053/tvjl.2000.0546 | 11,243,687 | D000818:Animals; D000914:Antibodies, Viral; D006734:Horse Diseases; D006736:Horses; D007112:Immunity, Maternally-Acquired; D007115:Immunization Schedule; D007117:Immunization, Secondary; D009980:Influenza A virus; D007252:Influenza Vaccines; D009976:Orthomyxoviridae Infections; D013997:Time Factors; D022223:Vaccines, S... | Veterinary journal (London, England : 1997) | 2,001 | D000914:Antibodies, Viral; D007252:Influenza Vaccines; D022223:Vaccines, Subunit |
Colonization of burns and the duration of hospital stay of severely burned patients. | In a retrospective study the influence of several factors on the length of hospital stay of severely burned patients (at least 24% total body surface area) has been investigated. The influence of these factors was studied by means of the Cox model survival analysis with time-varying covariates. Seventy-one patients wer... | 10.1016/0195-6701(92)90130-e | 1,358,947 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001419:Bacteria; D002053:Burn Units; D002056:Burns; D002648:Child; D002675:Child, Preschool; D015169:Colony Count, Microbial; D004755:Enterobacteriaceae; D005260:Female; D006801:Humans; D007223:Infant; D007902:Length of Stay; D008297:Male; D00... | The Journal of hospital infection | 1,992 | |
Systematic review of research on railway and urban transit system suicides. | INTRODUCTION
We critically review research on railway suicides to inform suicide prevention initiatives and future studies, including who is at risk and why, and behaviours at track locations.
METHOD
Literature was identified from Scopus, Web of Science, Google Scholar and our documentation centre, and contacting 71 ... | 26,773,913 | D000367:Age Factors; D062306:Geography, Medical; D006304:Health Status; D006801:Humans; D015994:Incidence; D017533:Marital Status; D015995:Prevalence; D011890:Railroads; D012737:Sex Factors; D012923:Social Class; D059020:Suicidal Ideation; D013405:Suicide; D013406:Suicide, Attempted; D013997:Time Factors; D000092864:Su... | Journal of affective disorders | 2,016 | ||
Continuous-Flow Synthesis of Pyrylium Tetrafluoroborates: Application to Synthesis of Katritzky Salts and Photoinduced Cationic RAFT Polymerization. | Katritzky salts have emerged as effective alkyl radical sources upon metal- or photocatalysis. These are typically prepared from the corresponding triarylpyrylium ions, in turn an important class of photocatalysts for small molecules synthesis and photopolymerization. Here, a flow method for the rapid synthesis of both... | 10.1021/acs.orglett.1c00178 | 33,650,879 | Organic letters | 2,021 | ||
Suicide in the Northern Territory, 1981-2002. | OBJECTIVE
To examine trends in suicide in the Northern Territory between 1981 and 2002, and demographic and other characteristics of people completing suicide in the Top End region in 2000-2002.
DESIGN
Retrospective descriptive analysis of Australian Bureau of Statistics death registration data and data from the NT C... | 10.5694/j.1326-5377.2006.tb00585.x | 16,999,672 | D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D003431:Cross-Cultural Comparison; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D044468:Native Hawaiian or Other Pacific Islander; D015876:Northern Territory; D015995:Prevalence; D012042:Registries; D0121... | The Medical journal of Australia | 2,006 | |
Cloning and expression of a lignin peroxidase gene from Streptomyces viridosporus in Streptomyces lividans. | A lignin peroxidase gene was cloned from Streptomyces viridosporus T7A into Streptomyces lividans TK64 in plasmid pIJ702. BglII-digested genomic DNA (4-10 kb) of S. viridosporus was shotgun-cloned into S. lividans after insertion into the melanin (mel+) gene of pIJ702. Transformants expressing pIJ702 with insert DNA we... | 10.1016/0168-1656(90)90099-w | 1,366,423 | D003001:Cloning, Molecular; D015870:Gene Expression; D005798:Genes, Bacterial; D010544:Peroxidases; D010957:Plasmids; D011994:Recombinant Proteins; D013302:Streptomyces | Journal of biotechnology | 1,990 | D011994:Recombinant Proteins; D010544:Peroxidases; C042858:lignin peroxidase |
Increased susceptibility of aged rats to haemorrhage and intravascular hypercoagulation following endotoxin administered in a generalized Shwartzman regime. | Ageing rats are known to have an increased incidence of myocardial fibrosis and dyspnoea caused by pulmonary intravascular coagulation. In order to determine whether endotoxin can be responsible for such responses in ageing rats we have exposed rats of differing ages (2 months, 16 months and 24 months) to single or rep... | 10.1016/s0021-9975(08)80200-9 | 1,761,762 | D000375:Aging; D000818:Animals; D003864:Depression, Chemical; D004198:Disease Susceptibility; D004211:Disseminated Intravascular Coagulation; D004731:Endotoxins; D005342:Fibrinolysis; D006470:Hemorrhage; D008297:Male; D051381:Rats; D012790:Shwartzman Phenomenon; D014148:Tranexamic Acid | Journal of comparative pathology | 1,991 | D004731:Endotoxins; D014148:Tranexamic Acid |
Immunization of calves with live and inactivated whole-cell vaccines against Salmonella typhimurium infection. | Eight calves were immunized with live auxotrophic Salmonella typhimurium mutants (aro -SL 1479, gal E 3821) and twelve calves with phenol-killed whole-cell S. typhimurium vaccine, respectively. The clinical status of the animals was followed and serial reisolation of vaccine and challenge strains from faeces was attemp... | 2,697,145 | D000818:Animals; D001428:Bacterial Vaccines; D002417:Cattle; D002418:Cattle Diseases; D005260:Female; D008297:Male; D012481:Salmonella Infections, Animal; D012486:Salmonella typhimurium; D014611:Vaccination; D015164:Vaccines, Inactivated | Acta veterinaria Hungarica | 1,989 | D001428:Bacterial Vaccines; D015164:Vaccines, Inactivated | |
The Terminal Oxidase Cytochrome bd Promotes Sulfide-resistant Bacterial Respiration and Growth. | Hydrogen sulfide (H2S) impairs mitochondrial respiration by potently inhibiting the heme-copper cytochrome c oxidase. Since many prokaryotes, including Escherichia (E.) coli, generate H2S and encounter high H2S levels particularly in the human gut, herein we tested whether bacteria can sustain sulfide-resistant O2-depe... | 10.1038/srep23788 | 27,030,302 | D000332:Aerobiosis; D003486:Cyanides; D003573:Cytochrome b Group; D003580:Cytochromes; D045222:Electron Transport Chain Complex Proteins; D004926:Escherichia coli; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial; D006862:Hydrogen Sulfide; D007527:Isoenzymes; D007700:Kinetics; D010088:Ox... | Scientific reports | 2,016 | D003486:Cyanides; D003573:Cytochrome b Group; D003580:Cytochromes; D045222:Electron Transport Chain Complex Proteins; D029968:Escherichia coli Proteins; D007527:Isoenzymes; C083850:cytochrome bo3, E coli; D010088:Oxidoreductases; C040077:cytochrome bd terminal oxidase complex, E coli; D010100:Oxygen; D006862:Hydrogen S... |
The Prognostic Value of Preoperative Serum D-dimer Levels After Surgical Resection of Thymic Epithelial Tumors. | INTRODUCTION
Thymic epithelial tumors are the most common mediastinal tumors. Despite the high survival rate after surgery, some patients still require postoperative adjuvant therapy and closer follow-up. Hematological indicators such as biochemical routines and coagulation indicators have been reported to be independe... | 10.1177/10732748221129108 | 36,373,938 | D006801:Humans; D011379:Prognosis; D012189:Retrospective Studies; D009375:Neoplasms, Glandular and Epithelial; D005340:Fibrinogen; D009367:Neoplasm Staging | Cancer control : journal of the Moffitt Cancer Center | 2,022 | C036309:fibrin fragment D; D005340:Fibrinogen |
[Influence of bacterial infection and formalin vapors on the course of ovalbumin induced experimental bronchospastic reaction in guinea pigs]. | The pathomechanism of the bronchospastic reaction is not fully explained. Ovalbumin induced bronchospastic reaction in guinea pigs is widely accepted as a classical experimental model and was appleid in this study. The bronchoconstriction, bronchial hypersensitivity and humoral immune response were measured after bronc... | 7,581,053 | D000818:Animals; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D001986:Bronchial Spasm; D003165:Complement System Proteins; D005260:Female; D005557:Formaldehyde; D006168:Guinea Pigs; D010047:Ovalbumin; D011552:Pseudomonas Infections; D012130:Respiratory Hypersensitivity | Pneumonologia i alergologia polska | 1,995 | D000936:Antigen-Antibody Complex; D005557:Formaldehyde; D010047:Ovalbumin; D003165:Complement System Proteins | |
Maternal stress induced anxiety-like behavior exacerbated by electromagnetic fields radiation in female rats offspring. | There is a disagreement on whether extremely low frequency electromagnetic fields (ELF-EMF) have a beneficial or harmful effect on anxiety-like behavior. Prenatal stress induces frequent disturbances in offspring physiology such as anxiety-like behavior extending to adulthood. This study was designed to evaluate the ef... | 10.1371/journal.pone.0273206 | 35,998,127 | D000818:Animals; D001007:Anxiety; D003345:Corticosterone; D004574:Electromagnetic Fields; D005260:Female; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate; D012701:Serotonin; D013315:Stress, Psychological | PloS one | 2,022 | D016194:Receptors, N-Methyl-D-Aspartate; D012701:Serotonin; D003345:Corticosterone |
Effectiveness of a 3D simulation tool to teach the designing of metal removable partial dentures: A mixed-method study. | INTRODUCTION
Acquiring insights into the framework design of metal-based removable partial dentures (mRPD) is a current challenge in dental education. The aim of the present study was to explore the effectiveness of a novel 3D simulation tool to teach designing mRPD by investigating the learning gain and the acceptance... | 10.1111/eje.12906 | 36,976,773 | D006801:Humans; D003832:Denture, Partial, Removable; D004497:Education, Dental; D007858:Learning; D013334:Students; D009042:Motivation | European journal of dental education : official journal of the Association for Dental Education in Europe | 2,023 | |
A hybrid probe system for quantifying plasma parameters in a 13.56 MHz capacitive coupled magnetized plasma. | A hybrid probe comprising of a combination of dual cylindrical and an emissive probe is developed to characterize magnetized plasma parameters in a 13.56 MHz capacitive coupled radio-frequency (RF) discharge, operated in push-pull configuration. The obtained plasma density has been verified against a standard resonance... | 10.1063/1.5053141 | 30,501,300 | The Review of scientific instruments | 2,018 | ||
Anthropogenic remediation of heavy metals selects against natural microbial remediation. | In an era of unprecedented environmental change, there have been increasing ecological and global public health concerns associated with exposure to anthropogenic pollutants. While there is a pressing need to remediate polluted ecosystems, human intervention might unwittingly oppose selection for natural detoxification... | 10.1098/rspb.2019.0804 | 31,213,187 | D001673:Biodegradation, Environmental; D017610:Calcium Compounds; D017753:Ecosystem; D052918:Environmental Restoration and Remediation; D006801:Humans; D019216:Metals, Heavy; D010087:Oxides; D017262:Siderophores; D012988:Soil Microbiology; D012989:Soil Pollutants | Proceedings. Biological sciences | 2,019 | D017610:Calcium Compounds; D019216:Metals, Heavy; D010087:Oxides; D017262:Siderophores; D012989:Soil Pollutants; C016538:lime |
Study of optimal vaccination strategies for early COVID-19 pandemic using an age-structured mathematical model: A case study of the USA. | In this paper we study different vaccination strategies that could have been implemented for the early COVID-19 pandemic. We use a demographic epidemiological mathematical model based on differential equations in order to investigate the efficacy of a variety of vaccination strategies under limited vaccine supply. We u... | 10.3934/mbe.2023481 | 37,322,963 | D006801:Humans; D000086382:COVID-19; D058873:Pandemics; D014611:Vaccination; D017589:Immunization Programs; D012307:Risk Factors | Mathematical biosciences and engineering : MBE | 2,023 | |
Modulation by somatostatin of rat parotid salivary secretion stimulated by cholinergic, adrenergic and peptidergic agents. | Although it is well known that somatostatin (SRIF) modulates several digestive functions, there are only a few reports about its effect on the salivary glands. Here, the action of SRIF parotid secretion was studied, in vivo and in vitro, in male Wistar rats. In vivo SRIF infusion (35 microg/kg per hr) inhibited the par... | 10.1016/s0003-9969(99)00035-7 | 10,414,870 | D018663:Adrenergic Agents; D000681:Amylases; D000818:Animals; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D007545:Isoproterenol; D008297:Male; D016210:Methacholine Chloride; D009638:Norepinephrine; D010306:Parotid Gland; D051381:Rats; D017208:Rats, Wistar; D012463:Saliva; D012471:Salivary Prot... | Archives of oral biology | 1,999 | D018663:Adrenergic Agents; D012471:Salivary Proteins and Peptides; D016210:Methacholine Chloride; D013373:Substance P; D013004:Somatostatin; D000681:Amylases; D007545:Isoproterenol; D009638:Norepinephrine |
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