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Illicit use of methadone and buprenorphine among adolescents and young adults in Sweden. | BACKGROUND
Illicit use of methadone and buprenorphine has been described as a growing problem in Sweden in recent years, and has been associated with an increased drug-related mortality. Critics claim that the substances have become popular among adolescents and that they function as a gateway to heroin use. The aim of... | 10.1186/1477-7517-10-27 | 24,139,199 | D000293:Adolescent; D000328:Adult; D001291:Attitude of Health Personnel; D002047:Buprenorphine; D003627:Data Interpretation, Statistical; D016208:Databases, Factual; D005260:Female; D006306:Health Surveys; D006801:Humans; D013287:Illicit Drugs; D008297:Male; D002189:Marijuana Abuse; D008691:Methadone; D009294:Narcotics... | Harm reduction journal | 2,013 | D013287:Illicit Drugs; D009294:Narcotics; D002047:Buprenorphine; D008691:Methadone |
Association of Insulin-like Growth Factor-1, Bone Mass and Inflammation to Low-energy Distal Radius Fractures and Fracture Healing in Elderly Women Attending Emergency Care. | OBJECTIVE
Elderly patients suffer fractures through low-energy mechanisms. The distal radius is the most frequent fracture localization. Insulin-like growth factor-1 (IGF1) plays an important role in the maintenance of bone mass and its levels decline with advancing age and in states of malnutrition. Our aim was to inv... | 10.1111/os.12358 | 29,178,313 | D015502:Absorptiometry, Photon; D000058:Accidental Falls; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D015519:Bone Density; D004632:Emergency Medical Services; D005260:Female; D005500:Follow-Up Studies; D005592:Fracture Fixation; D017102:Fracture Healing; D006801:Humans; D007249:Inflammation; D007334:I... | Orthopaedic surgery | 2,017 | D015415:Biomarkers; C583557:IGF1 protein, human; D007334:Insulin-Like Growth Factor I |
Regulation of bile acid synthesis. V. Inhibition of conversion of 7-dehydrocholesterol to cholesterol is associated with down-regulation of cholesterol 7 alpha-hydroxylase activity and inhibition of bile acid synthesis. | In the chronic bile fistula rat, the administration of a bolus dose of mevinolinic acid, an inhibitor of HMG-CoA reductase, was followed by rapid down-regulation of cholesterol 7 alpha-hydroxylase activity and a decrease in bile acid synthesis. These observations suggested that either newly synthesized cholesterol or s... | 1,708,805 | D000214:Acyl Coenzyme A; D000818:Animals; D001647:Bile Acids and Salts; D002784:Cholesterol; D002790:Cholesterol 7-alpha-Hydroxylase; D003684:Dehydrocholesterols; D015536:Down-Regulation; D007700:Kinetics; D008099:Liver; D008297:Male; D008798:Mevalonic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D001371:trans-1,4... | Journal of lipid research | 1,990 | D000214:Acyl Coenzyme A; D001647:Bile Acids and Salts; D003684:Dehydrocholesterols; C008047:3-hydroxy-3-methylglutaryl-coenzyme A; D001371:trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; C015367:mevalonolactone; D002784:Cholesterol; C016705:7-dehydrocholesterol; D002790:Cholesterol 7-alpha-Hydroxylas... | |
Investigating the possible mechanisms involved in adenosine preconditioning-induced cardioprotection in rats. | BACKGROUND
Adenosine is a breakdown product of adenosine triphosphate and plays an important role in pharmacological preconditioning. The cardioprotective effects of adenosine preconditioning are well established. However, the possible mechanisms need to be explored.
AIM
This study was aimed to investigate the possib... | 10.1111/1755-5922.12328 | 29,604,187 | D000241:Adenosine; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002316:Cardiotonic Agents; D000697:Central Nervous System Stimulants; D003402:Creatine Kinase; D004347:Drug Interactions; D066298:In Vitro Techniques; D019157:Ischemic Preconditioning, Myocardial; D000067268:Isolated Heart Preparation... | Cardiovascular therapeutics | 2,018 | D000894:Anti-Inflammatory Agents, Non-Steroidal; D002316:Cardiotonic Agents; D000697:Central Nervous System Stimulants; D020024:Leukotriene Antagonists; D009569:Nitric Oxide; D007770:L-Lactate Dehydrogenase; D019001:Nitric Oxide Synthase; D003402:Creatine Kinase; D000241:Adenosine |
Parents' awareness and knowledge of testicular torsion: A cross-sectional study. | BACKGROUND
Testicular torsion (TT) is one of the most common emergencies in pediatric urology. Family awareness of this condition could lead to early diagnosis and intervention and salvage of the effected testicle. The purpose of this study is to assess parental awareness about TT and their source of knowledge. We also... | 10.4103/UA.UA_62_18 | 30,787,572 | Urology annals | 2,019 | ||
Comprehensive disease management for schizophrenia. | This is a period of rapid development in the pharmacotherapy of schizophrenia. New generation antipsychotic medications appear overall to be more efficacious and better tolerated than the older, conventional antipsychotics. Moreover, these atypical antipsychotics appear to have a broader profile of efficacy which likel... | 10.1358/dot.2000.36.5.575040 | 12,861,351 | Drugs of today (Barcelona, Spain : 1998) | 2,000 | ||
Vitamin K1 accumulation in tobacco plants overexpressing bacterial genes involved in the biosynthesis of salicylic acid. | Phylloquinone (Vitamin K(1)) is an essential component of the photosynthetic electron transfer. As isochorismate is required for the biosynthesis of Vitamin K(1), isochorismate synthase (ICS) activity is expected to be present in all green plants. In bacteria salicylic acid (SA) is synthesized via a two step pathway in... | 10.1016/j.jbiotec.2006.09.005 | 17,084,477 | D001426:Bacterial Proteins; D053898:Biosynthetic Pathways; D019757:Carbon-Oxygen Lyases; D002827:Chorismic Acid; D003509:Cyclohexanecarboxylic Acids; D053138:Cyclohexenes; D019751:Intramolecular Transferases; D030821:Plants, Genetically Modified; D011994:Recombinant Proteins; D020156:Salicylic Acid; D014026:Nicotiana; ... | Journal of biotechnology | 2,007 | D001426:Bacterial Proteins; D003509:Cyclohexanecarboxylic Acids; D053138:Cyclohexenes; D011994:Recombinant Proteins; D010837:Vitamin K 1; D019757:Carbon-Oxygen Lyases; C517864:isochorismate pyruvate lyase, Nicotiana tabacum; D019751:Intramolecular Transferases; C058486:isochorismate synthase; D002827:Chorismic Acid; D0... |
Effect of iodinated low-osmolar contrast media on the hemostatic system after intraarterial and intravenous contrast administration. | PURPOSE
Some of the adverse clinical effects of intravascular radiological contrast agents include the interference of these contrast media with normal hemostatic processes. The aim of this report was to investigate in vivo whether a non-ionic iodinated contrast agent possess prothrombotic or anticoagulant properties.
... | 23,183,764 | D000368:Aged; D001779:Blood Coagulation Factors; D003287:Contrast Media; D005260:Female; D006487:Hemostasis; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D007472:Iohexol; D007479:Iopamidol; D008297:Male; D008875:Middle Aged | Advances in medical sciences | 2,012 | D001779:Blood Coagulation Factors; D003287:Contrast Media; C057937:iomeprol; D007472:Iohexol; C038192:iopromide; D007479:Iopamidol | |
Use of Research Evidence and Implementation of Evidence-Based Practices in Youth-Serving Systems. | Although the effectiveness of interventions for prevention and treatment of mental health and behavioral problems in abused and neglected youth is demonstrated through the accumulation of evidence through rigorous and systematic research, it is uncertain whether use of research evidence (URE) by child-serving systems l... | 10.1016/j.childyouth.2017.11.005 | 29,170,572 | Children and youth services review | 2,017 | ||
Targeting hepcidin improves cognitive impairment and reduces iron deposition in a diabetic rat model. | Cognitive impairment is a common complication of type 2 diabetes mellitus (T2DM) that may be related to iron deposition in the brain. Hepcidin is expressed in the brain and has the ability to regulate iron. Therefore, this study explored the role of hepcidin in hippocampal iron deposition and cognitive impairment in T2... | 32,913,554 | American journal of translational research | 2,020 | |||
[Effects of testosterone on extracellular signal-regulated kinase 1/2 phosphorylation in human umbilical vein endothelial cells]. | OBJECTIVE
To investigate the effects of testosterone on extracellular signal-regulated kinase l/2 ( ERK1/2) phosphorylation in human umbilical vein endothelial cells (HUVEC).
METHODS
Activations of ERK1/2 stimulated by physiological testosterone were detected by Western blotting in cultured HUVEC.
RESULTS
A rapid p... | 17,929,550 | D059002:Androgen Receptor Antagonists; D015153:Blotting, Western; D002478:Cells, Cultured; D042783:Endothelial Cells; D004789:Enzyme Activation; D048049:Extracellular Signal-Regulated MAP Kinases; D006801:Humans; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D010766:Phosphoryla... | Zhonghua nan ke xue = National journal of andrology | 2,007 | D059002:Androgen Receptor Antagonists; D011944:Receptors, Androgen; D013739:Testosterone; D048049:Extracellular Signal-Regulated MAP Kinases; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3 | |
Antenatal steroid therapy and childhood asthma: Is there a possible link? | This paper presents a hypothesis that fetal exposure to corticosteroids is an independent risk factor for the development of asthma in childhood. The prevalence of childhood asthma saw a dramatic rise from the 1980s up until the early 2000s. Among the explanations for the increase in asthma prevalence included interest... | 10.1016/j.mehy.2007.07.049 | 17,961,931 | D000305:Adrenal Cortex Hormones; D001249:Asthma; D002648:Child; D005260:Female; D006801:Humans; D008168:Lung; D008297:Male; D018811:Maternal Exposure; D008954:Models, Biological; D008962:Models, Theoretical; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012306:Risk; D013256:Steroids | Medical hypotheses | 2,008 | D000305:Adrenal Cortex Hormones; D013256:Steroids |
Three-dimensional information in face recognition: an eye-tracking study. | One unresolved question about face perception is: what is the role of three-dimensional information in face recognition? In this study, recognition performance was compared across changes in viewpoint in different depth conditions: a 2D condition without stereo information and a 3D condition where stereo information wa... | 22,131,448 | D000328:Adult; D003463:Cues; D003867:Depth Perception; D005133:Eye Movements; D005145:Face; D005260:Female; D005403:Fixation, Ocular; D006801:Humans; D008297:Male; D010364:Pattern Recognition, Visual; D055815:Young Adult | Journal of vision | 2,011 | ||
Do Patterns of Opioid Prescriptions to Medicare Beneficiaries Differ Between Oral and Maxillofacial Surgeons Practicing in Urban and Rural Settings? | PURPOSE
This study compared opioid prescription patterns among oral and maxillofacial surgeons (OMSs) treating Medicare beneficiaries in urban and rural settings, in an effort to identify avenues to further promote responsible opioid prescribing in a patient demographic vulnerable to opioid diversion.
MATERIALS AND M... | 10.1016/j.joms.2021.10.018 | 34,856,159 | D000368:Aged; D000701:Analgesics, Opioid; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D006278:Medicare; D000066794:Oral and Maxillofacial Surgeons; D019239:Practice Patterns, Dentists'; D010818:Practice Patterns, Physicians'; D055656:Prescriptions; D014481:United States | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | 2,022 | D000701:Analgesics, Opioid |
Health psychology: status and trends. | This study investigated the present status and suggested trends in health psychology as reported by American Psychological Association Division 38 (Health Psychology) members. A 25-item mail-in survey was developed to obtain these data from a randomly selected sample of 300. Information includes a demographic descripti... | 10.2466/pr0.1991.69.1.189 | 1,961,788 | D001294:Attitude to Health; D002908:Chronic Disease; D005544:Forecasting; D015438:Health Behavior; D006266:Health Education; D006801:Humans | Psychological reports | 1,991 | |
[The potentials for the balneotherapy of obesity using arsenic-containing mineral water]. | Arsenic mineral water from the Sinegorsk springs was tried in the treatment of experimental alimentary obesity in rat Wistar males and patients with exogenous-constitutional obesity. Body mass, blood lipids, hepatic neutral lipids, glucose-6-phosphate-dehydrogenase were measured. Arsenic mineral water proved able to re... | 9,771,136 | D000328:Adult; D000818:Animals; D001152:Arsenicals; D001452:Balneology; D001835:Body Weight; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008055:Lipids; D008297:Male; D008875:Middle Aged; D008900:Mineral Waters; D009765:Obesity;... | Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury | 1,998 | D001152:Arsenicals; D008055:Lipids; D008900:Mineral Waters | |
Automated washing of human progenitor cells: evaluation of apoptosis and cell necrosis. | BACKGROUND
High-dose chemotherapy followed by reinfusion of autologous stem cells harvested from peripheral blood has been increasingly applied for a variety of disorders. The critical importance of cell dose in the clinical outcome, after transplant, has motivated the need to develop techniques aimed at reducing cell ... | 10.1111/j.1365-3148.2011.01103.x | 22,032,614 | D018952:Antigens, CD34; D017209:Apoptosis; D001331:Automation; D002452:Cell Count; D003257:Consumer Product Safety; D015925:Cryopreservation; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells; D006801:Humans; D009336:Necrosis; D015203:Reproducibility of Results | Transfusion medicine (Oxford, England) | 2,011 | D018952:Antigens, CD34 |
Donor-derived Strongyloides stercoralis infection in solid organ transplant recipients in the United States, 2009-2013. | Infection with Strongyloides stercoralis is typically asymptomatic in immunocompetent hosts, despite chronic infection. In contrast, immunocompromised hosts such as solid organ transplant recipients are at risk for hyperinfection syndrome and/or disseminated disease, frequently resulting in fatal outcomes. Infection in... | 10.1111/ajt.13137 | 25,703,251 | D000328:Adult; D000368:Aged; D000818:Animals; D002487:Centers for Disease Control and Prevention, U.S.; D046148:Donor Selection; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation; D007843:Latin America; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D01118... | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons | 2,015 | |
Prediction of plasma volume and total hemoglobin mass with machine learning. | Hemoglobin concentration ([Hb]) is used for the clinical diagnosis of anemia, and in sports as a marker of blood doping. [Hb] is however subject to significant variations mainly due to shifts in plasma volume (PV). This study proposes a newly developed model able to accurately predict total hemoglobin mass (Hbmass) and... | 10.14814/phy2.15834 | 37,828,664 | D008297:Male; D006801:Humans; D005260:Female; D010953:Plasma Volume; D006454:Hemoglobins; D004300:Doping in Sports; D000886:Anthropometry; D000740:Anemia | Physiological reports | 2,023 | D006454:Hemoglobins |
Genetic approaches to the study of protein-protein interactions. | This article describes genetic approaches to the study of heterologous protein-protein interactions, focusing on the yeast Saccharomyces cerevisiae as a useful eukaryotic model system. Several methods are described that can be used to search for new interactions, including extragenic suppression, multicopy suppression,... | 10.1006/meth.1999.0861 | 10,527,736 | D003001:Cloning, Molecular; D005804:Genes, Lethal; D016153:Genes, Suppressor; D005813:Genes, Synthetic; D005821:Genetic Techniques; D016296:Mutagenesis; D019151:Peptide Library; D017354:Point Mutation; D011485:Protein Binding; D011506:Proteins; D011994:Recombinant Proteins | Methods (San Diego, Calif.) | 1,999 | D019151:Peptide Library; D011506:Proteins; D011994:Recombinant Proteins |
trans-sialidase inhibition assay, a highly sensitive and specific diagnostic test for Chagas' disease. | For the diagnosis of Chagas' disease, the trans-sialidase inhibition assay was able to resolve the results for samples with borderline results, to detect as positive 60% of samples that were negative by conventional serology, and to discriminate idiopathic from chagasic megaviscera or cardiopathy. No cross-reaction wit... | 10.1128/CDLI.8.1.187-189.2001 | 11,139,217 | D000818:Animals; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D001327:Autoimmune Diseases; D001938:Brazil; D014355:Chagas Disease; D003429:Cross Reactions; D006023:Glycoproteins; D006801:Humans; D016773:Leishmaniasis, Cutaneous; D008288:Malaria; D009439:Neuraminidase; D009500:Neutralization Tests; D01023... | Clinical and diagnostic laboratory immunology | 2,001 | D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D006023:Glycoproteins; C069715:trans-sialidase; D009439:Neuraminidase |
Biostimulation is a valuable tool to assess pesticide biodegradation capacity of groundwater microorganisms. | Groundwater is the main source for drinking water production globally. Groundwater unfortunately can contain micropollutants (MPs) such as pesticides and/or pesticide metabolites. Biological remediation of MPs in groundwater requires an understanding of natural biodegradation capacity and the conditions required to sti... | 10.1016/j.chemosphere.2021.130793 | 34,162,094 | D001673:Biodegradation, Environmental; D060587:Groundwater; D009566:Nitrates; D010575:Pesticides; D014874:Water Pollutants, Chemical | Chemosphere | 2,021 | D009566:Nitrates; D010575:Pesticides; D014874:Water Pollutants, Chemical |
Assessment of homology templates and an anesthetic binding site within the γ-aminobutyric acid receptor. | BACKGROUND
Anesthetics mediate portions of their activity via modulation of the γ-aminobutyric acid receptor (GABAaR). Although its molecular structure remains unknown, significant progress has been made toward understanding its interactions with anesthetics via molecular modeling.
METHODS
The structure of the torped... | 10.1097/ALN.0b013e31829e47e3 | 23,770,602 | D000465:Algorithms; D000777:Anesthetics; D000818:Animals; D001665:Binding Sites; D018118:Chloride Channels; D018360:Crystallography, X-Ray; D007473:Ion Channels; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008854:Microscopy, Electron; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D018079:... | Anesthesiology | 2,013 | D000777:Anesthetics; D018118:Chloride Channels; D007473:Ion Channels; D018079:Receptors, GABA; D011978:Receptors, Nicotinic; C105813:nicotinic acetylcholine receptor alpha4 subunit |
Improvements for extending the time between maintenance periods for the Heidelberg ion beam therapy center (HIT) ion sources. | The clinical operation at the Heidelberg Ion Beam Therapy Center (HIT) started in November 2009; since then more than 1600 patients have been treated. In a 24/7 operation scheme two 14.5 GHz electron cyclotron resonance ion sources are routinely used to produce protons and carbon ions. The modification of the low energ... | 10.1063/1.4860651 | 24,593,530 | D017357:Cyclotrons; D008283:Maintenance; D011878:Radiotherapy; D013997:Time Factors | The Review of scientific instruments | 2,014 | |
[Medullary carcinoma of the thyroid. Clinical case]. | A 13 year old girl presented with a thyroid nodule and enlarged cervical lymph nodes. Symptoms endocrine dysfunction were absent. The patient was submitted to complete thyroidectomy and modified cervical lymph node dissection. Diagnosis of medullary carcinoma was confirmed through both optical and electron microscopy. ... | 2,519,398 | D000293:Adolescent; D002277:Carcinoma; D005260:Female; D006801:Humans; D013964:Thyroid Neoplasms; D013965:Thyroidectomy | Revista medica de Chile | 1,989 | ||
High expression of growth factor receptor-bound protein 14 predicts poor prognosis for colorectal cancer patients. | OBJECTS
To explore the roles of growth factor receptor-bound protein 14 (GRB14) in colorectal cancer (CRC) and its correlation with clinicopathological characteristics and prognosis of CRC patients.
RESULTS
GRB14 was localized in the cytoplasm of CRC and benign glandular epithelium cells, showing higher levels in CRC... | 10.1007/s10529-016-2077-4 | 26,965,150 | D048868:Adaptor Proteins, Signal Transducing; D000368:Aged; D014408:Biomarkers, Tumor; D015179:Colorectal Neoplasms; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged | Biotechnology letters | 2,016 | D048868:Adaptor Proteins, Signal Transducing; D014408:Biomarkers, Tumor; C099655:GRB14 protein, human |
Biomechanical comparison of the Lim/Tsai tendon repair with a modified method using a single looped suture. | The Lim/Tsai tendon repair technique has been modified clinically to achieve a 6-strand repair using a single looped suture with one extratendinous knot. We compared biomechanical performance of the original and modified methods using 20 porcine flexor digitorum profundus tendons. The ultimate tensile strength, load to... | 10.1177/1753193417723273 | 28,784,013 | D000818:Animals; D013536:Suture Techniques; D013537:Sutures; D013552:Swine; D013708:Tendon Injuries; D013718:Tensile Strength; D016474:Weight-Bearing | The Journal of hand surgery, European volume | 2,017 | |
Hybrid embryos of Vicia faba develop enhanced sink strength, which is established during early development. | Selfed and crossed seeds of two homozygous Vicia faba lines served as models for the analysis of the physiological and molecular mechanisms underlying embryo heterosis. Profiles of transcripts, metabolites and seed contents of developing embryos were analysed to compare the means of reciprocally crossed and selfed seed... | 10.1111/j.1365-313X.2010.04450.x | 21,235,645 | D049109:Cell Proliferation; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D018506:Gene Expression Regulation, Plant; D006823:Hybrid Vigor; D006824:Hybridization, Genetic; D018749:RNA, Plant; D012639:Seeds; D031307:Vicia faba | The Plant journal : for cell and molecular biology | 2,011 | D018749:RNA, Plant |
The aggregation of aβ42 induced by nano copper and the antagonistic action of polysaccharides. | The toxic effect of Aβ42 induced by copper nanoparticle (Cu NPs) was studied by atomic force microscopy (AFM), circular dichroism (CD) spectroscopy, and Thioflavin T (ThT) fluorescence technique. Five hundred nanometers of copper nanoparticle capped with polyvinylpyrrolidone (PVP) was used to evaluate the aggregation a... | 10.1007/s12010-014-1385-1 | 25,410,807 | D016229:Amyloid beta-Peptides; D052160:Benzothiazoles; D002942:Circular Dichroism; D003300:Copper; D005453:Fluorescence; D007700:Kinetics; D018625:Microscopy, Atomic Force; D053758:Nanoparticles; D010446:Peptide Fragments; D011134:Polysaccharides; D066329:Protein Aggregates; D017433:Protein Structure, Secondary; D01384... | Applied biochemistry and biotechnology | 2,015 | D016229:Amyloid beta-Peptides; D052160:Benzothiazoles; D010446:Peptide Fragments; D011134:Polysaccharides; D066329:Protein Aggregates; D013844:Thiazoles; C075222:amyloid beta-protein (1-42); C009462:thioflavin T; D003300:Copper |
Force-velocity test on a stationary cycle ergometer: methodological recommendations. | Force-velocity tests performed on stationary cycle ergometers are widely used to assess the torque- and power-generating capacities of the lower limbs. The aim of this study was to identify how testing and modeling procedures influence the assessment of individual torque-cadence and power-cadence relationships. Sevente... | 10.1152/japplphysiol.00719.2017 | 29,357,495 | D000328:Adult; D001642:Bicycling; D001696:Biomechanical Phenomena; D004576:Electromyography; D016552:Ergometry; D006801:Humans; D008297:Male; D005082:Physical Exertion; D019415:Torque | Journal of applied physiology (Bethesda, Md. : 1985) | 2,018 | |
Distortion-product and click-evoked otoacoustic emissions in healthy newborns. | Distortion-product otoacoustic emissions (DPOEs) are believed to provide frequency-specific information about cochlear function. The DPOEs have been reported in the adult population but have not been reported previously in the neonatal population. We recorded DPOEs from a group of healthy full-term newborn human subjec... | 10.1001/archotol.1991.01870240074012 | 1,845,266 | D000161:Acoustic Stimulation; D000328:Adult; D006801:Humans; D007231:Infant, Newborn; D017084:Otoacoustic Emissions, Spontaneous; D012815:Signal Processing, Computer-Assisted | Archives of otolaryngology--head & neck surgery | 1,991 | |
Genetic and environmental correlations between bone mineral density and bone size in Caucasians. | To explore the magnitude of common genetic and environmental effects shared by bone mineral density (BMD) and bone size (BS) in a large sample of 4,489 subjects (2,667 females and 1,822 males) from 582 Caucasian pedigrees, we performed a bivariate variance decomposition analysis to evaluate genetic correlation (rhoG), ... | 10.1353/hub.2007.0023 | 17,985,654 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015519:Bone Density; D005260:Female; D005828:Genetics, Population; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis; D010375:Pedigree; D010641:Phenotype; D044465:White People | Human biology | 2,007 | |
[The modification and variants of histone]. | The modification of histone plays a crucial role in regulating chromatin states that conserve transcription programs and provide a mechanism for chromatin states to be maintained as cells proliferate. A large number of factors and protein complexes are now known to be involved in regulating the dynamic states of the mo... | 17,685,219 | D000107:Acetylation; D000818:Animals; D002843:Chromatin; D006657:Histones; D006801:Humans; D008745:Methylation; D010766:Phosphorylation; D020033:Protein Isoforms | Molekuliarnaia biologiia | 2,007 | D002843:Chromatin; D006657:Histones; D020033:Protein Isoforms | |
Phenotypic and genetic differentiation of anxiety-related behaviors in middle childhood. | BACKGROUND
Anxiety-related behaviors (ARBs) are commonly observed during typical development, yet few studies have investigated their etiology in middle childhood. This study aimed to examine both the phenotypic and genetic differentiation of ARB subtypes within the general population at age 7 and 9. It constituted a f... | 10.1002/da.20539 | 19,194,998 | D001008:Anxiety Disorders; D002648:Child; D003937:Diagnosis, Differential; D004200:Diseases in Twins; D005163:Factor Analysis, Statistical; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D010641:Phenotype; D012720:Severity of Illness Index; D012931:Social Envi... | Depression and anxiety | 2,009 | |
Fasted C-Peptide Distribution and Associated Clinical Factors in Adults With Longstanding Type 1 Diabetes: Analysis of the Canadian Study of Longevity in Type 1 Diabetes. | OBJECTIVE
Although insulin production is reportedly retained in many people with longstanding type 1 diabetes (T1D), the magnitude and relevance of connecting peptide (C-peptide) production are uncertain. In this study, we aimed to define fasted C-peptide distributions and associated clinical factors.
METHODS
In a cr... | 10.1016/j.jcjd.2023.11.001 | 37,944,665 | Canadian journal of diabetes | 2,023 | ||
Within- and between-group regression for improving the robustness of causal claims in cross-sectional analysis. | BACKGROUND
A major objective of environmental epidemiology is to elucidate exposure-health outcome associations. To increase the variance of observed exposure concentrations, researchers recruit individuals from different geographic areas. The common analytical approach uses multilevel analysis to estimate individual-l... | 10.1186/s12940-015-0047-2 | 26,159,541 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D002097:C-Reactive Protein; D002210:Caprylates; D003430:Cross-Sectional Studies; D060766:Drinking Water; D004781:Environmental Exposure; D005466:Fluorocarbons; D005843:Geography; D006801:Humans; D018655:Lymphocyte Count; D008875:Middle Aged; D0... | Environmental health : a global access science source | 2,015 | D015415:Biomarkers; D002210:Caprylates; D060766:Drinking Water; D005466:Fluorocarbons; D014873:Water Pollutants; D002097:C-Reactive Protein; C031492:octanoic acid |
Clinical guideline for diagnosis and management of melioidosis. | Melioidosis is an emerging infection in Brazil and neighbouring South American countries. The wide range of clinical presentations include severe community-acquired pneumonia, septicaemia, central nervous system infection and less severe soft tissue infection. Diagnosis depends heavily on the clinical microbiology labo... | 10.1590/s0036-46652006000100001 | 16,547,571 | D000900:Anti-Bacterial Agents; D016957:Burkholderia pseudomallei; D002442:Ceftazidime; D002985:Clinical Protocols; D004318:Doxycycline; D006801:Humans; D008554:Melioidosis; D000077731:Meropenem; D017410:Practice Guidelines as Topic; D013845:Thienamycins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination | Revista do Instituto de Medicina Tropical de Sao Paulo | 2,006 | D000900:Anti-Bacterial Agents; D013845:Thienamycins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D002442:Ceftazidime; D000077731:Meropenem; D004318:Doxycycline |
Identification and preliminary validation of novel biomarkers of acute hepatic ischaemia/reperfusion injury using dual-platform proteomic/degradomic approaches. | Hepatic ischaemia/reperfusion (I/R), a major cause of liver damage associated with multiple trauma, haemorrhagic and septic shock, and liver transplantation, contributes significantly to multiple organ failure. Development of novel sensitive biomarkers that detect early stages of liver damage is vital for effective man... | 10.1080/13547500600775110 | 16,908,442 | D000818:Animals; D001124:Argininosuccinate Synthase; D015415:Biomarkers; D002853:Chromatography, Liquid; D005688:Galactosamine; D008070:Lipopolysaccharides; D008099:Liver; D008297:Male; D040901:Proteomics; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury; D015238:Sulfotransferases; D013997:Time Fa... | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals | 2,006 | D015415:Biomarkers; D008070:Lipopolysaccharides; D005688:Galactosamine; D015238:Sulfotransferases; C020122:estrone sulfotransferase; D001124:Argininosuccinate Synthase |
Seasonal Sex Ratio Trend in the European Kestrel: An Evolutionarily Stable Strategy Analysis. | We present an evolutionarily stable strategy (ESS) model to analyze selection on seasonal variation in the brood sex ratio, as observed in several species of raptorial birds. The model is specifically tailored to the life history of the European kestrel, and it reflects the maturation time hypothesis, the idea that a s... | 10.1086/303183 | 29,586,621 | The American naturalist | 1,999 | ||
Immunomodulatory effect of a decellularized skeletal muscle scaffold in a discordant xenotransplantation model. | Decellularized (acellular) scaffolds, composed of natural extracellular matrix, form the basis of an emerging generation of tissue-engineered organ and tissue replacements capable of transforming healthcare. Prime requirements for allogeneic, or xenogeneic, decellularized scaffolds are biocompatibility and absence of r... | 10.1073/pnas.1213228110 | 23,940,349 | D000818:Animals; D049109:Cell Proliferation; D016207:Cytokines; D015536:Down-Regulation; D005109:Extracellular Matrix; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D008264:Macrophages; D018482:Muscle, Skeletal; D011817:Rabbits; D054457:Tissue Scaffolds; D014183:Transplantat... | Proceedings of the National Academy of Sciences of the United States of America | 2,013 | D016207:Cytokines; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II |
A phase I study of EZN-3042, a novel survivin messenger ribonucleic acid (mRNA) antagonist, administered in combination with chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL): a report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium. | To address the therapeutic challenges in childhood relapsed ALL, a phase 1 study combining a survivin mRNA antagonist, EZN-3042, with reinduction chemotherapy was developed for pediatric patients with second or greater bone marrow relapses of B-lymphoblastic leukemia. EZN-3042 was administered as a single agent on days... | 10.1097/MPH.0b013e3182a8f58f | 24,276,047 | D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols; D001853:Bone Marrow; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007223:Infant; D051034:Inhibitor of Apoptosis Proteins; D008297:Male; D009364:Neop... | Journal of pediatric hematology/oncology | 2,014 | C107489:BIRC5 protein, human; C552302:EZN 3042; D051034:Inhibitor of Apoptosis Proteins; D009841:Oligonucleotides; D012333:RNA, Messenger; D000077022:Survivin |
Quantum theory of concerted electronic and nuclear fluxes associated with adiabatic intramolecular processes. | An elementary molecular process can be characterized by the flow of particles (i.e., electrons and nuclei) that compose the system. The flow, in turn, is quantitatively described by the flux (i.e., the time-sequence of maps of the rate of flow of particles though specified surfaces of observation) or, in more detail, b... | 10.1039/c5cp03982g | 26,480,293 | Physical chemistry chemical physics : PCCP | 2,015 | ||
Influence of Flow Disturbances behind the 90° Bend on the Indications of the Ultrasonic Flow Meter with Clamp-On Sensors on Pipelines. | The subject matter of the article concerns velocities/flow rate measurements in the area of disturbed flows-behind the 90° bend. They were conducted by means of an ultrasonic flowmeter with clamp-on sensors on pipeline, for water and two different Reynolds numbers of 70,000 and 100,000, corresponding to two velocities ... | 10.3390/s21030868 | 33,525,446 | Sensors (Basel, Switzerland) | 2,021 | ||
Antroduodenal motility in children with chronic intestinal pseudo-obstruction. | Chronic intestinal pseudo-obstruction describes a heterogeneous group of disorders characterized by signs and symptoms of intestinal obstruction in the absence of a mechanical lesion. We studied antroduodenal motility in 13 children with pseudo-obstruction. The diagnosis was based on radiographic evidence in all, surge... | 10.1016/s0022-3476(88)80211-7 | 3,373,394 | D002648:Child; D002675:Child, Preschool; D020117:Cisapride; D004386:Duodenum; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D007223:Infant; D007418:Intestinal Pseudo-Obstruction; D008297:Male; D010880:Piperidines; D011706:Pyloric Antrum | The Journal of pediatrics | 1,988 | D010880:Piperidines; D020117:Cisapride |
Selective recording of neuroelectric activity from the peripheral nerve. | Electroneurograms (ENGs) from superficial regions of the sciatic nerve of a dog, innervating the tibialis anterior (TA) and gastrocnemius muscles (GM), arising mainly from muscle spindles and Golgi tendon organs were recorded selectively with an implanted 33-electrode spiral cuff (cuff). Relative positions of superfici... | 11,005,653 | D000818:Animals; D000842:Ankle; D004285:Dogs; D004594:Electrophysiology; D008465:Mechanoreceptors; D009470:Muscle Spindles; D018482:Muscle, Skeletal; D009412:Nerve Fibers; D012399:Rotation; D012584:Sciatic Nerve; D013314:Stress, Mechanical | Pflugers Archiv : European journal of physiology | 2,000 | ||
Integrated computational approaches to screen gene expression data to determine key genes and therapeutic targets for type-2 diabetes mellitus. | There is a rapid rise in cases of Type-2-diabetes mellitus (T2DM) globally, irrespective of the geography, ethnicity or any other variable factors. The molecular mechanisms that could cause the condition of T2DM need to be more thoroughly analysed to understand the clinical manifestations and to derive better therapeut... | 10.1016/j.sjbs.2022.02.004 | 35,844,380 | Saudi journal of biological sciences | 2,022 | ||
miRNA profiling in metastatic renal cell carcinoma reveals a tumour-suppressor effect for miR-215. | BACKGROUND
Renal cell carcinoma (RCC) is the most common neoplasm of the adult kidney. Metastatic RCC is difficult to treat. The 5-year survival rate for metastatic RCC is ≤10%. Recently, microRNAs (miRNAs) have been shown to have a role in cancer metastasis and potential as prognostic biomarkers in cancer.
METHOD
We... | 10.1038/bjc.2011.401 | 22,033,272 | D014408:Biomarkers, Tumor; D002292:Carcinoma, Renal Cell; D048708:Cell Growth Processes; D045744:Cell Line, Tumor; D002465:Cell Movement; D018450:Disease Progression; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D005820:Genetic Testing; D018398:Home... | British journal of cancer | 2,011 | D014408:Biomarkers, Tumor; C108381:GEMIN2 protein, human; D018398:Homeodomain Proteins; C553667:MIRN215 microRNA, human; D035683:MicroRNAs; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; D012097:Repressor Proteins; C492363:ZEB2 protein, human; D000074165:Zinc Finger E-box Binding Homeobox 2 |
Evidence for the importance of angiotensin II type 1 receptor in ischemia-induced angiogenesis. | The role of the renin-angiotensin system (RAS) in angiogenesis is little known. Here, we show that the angiotensin II (ATII) type 1 (AT1) receptor plays an important role in ischemia-induced angiogenesis. Well-developed collateral vessels and angiogenesis were observed in wild-type (WT) mice in response to hindlimb isc... | 10.1172/JCI13055 | 11,877,468 | D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001794:Blood Pressure; D002196:Capillaries; D018932:Chemokine CCL2; D016228:Endothelial Growth Factors; D006614:Hindlimb; D006830:Hydralazine; D007093:Imidazoles; D007249:Inflammation; D007511:Ischemia; D007963:Leukocytes, Mononuclear; D008222:Lymphokines; D00... | The Journal of clinical investigation | 2,002 | D057911:Angiotensin Receptor Antagonists; D018932:Chemokine CCL2; D016228:Endothelial Growth Factors; D007093:Imidazoles; D008222:Lymphokines; D011725:Pyridines; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Facto... |
[Acute interstitial nephritis of fluindione: about three cases]. | Acute interstitial nephritis is a frequent cause of acute renal failure, representing about 10% of all biopsied cases. Early recognition of drug-induced acute immunoallergic interstitial nephritis prevents the development of severe chronic renal injury. The list of imputable drugs includes phenindione, a vitamin K anta... | 10.1016/j.nephro.2008.02.003 | 18,417,438 | D000208:Acute Disease; D058186:Acute Kidney Injury; D000368:Aged; D000925:Anticoagulants; D004232:Diuretics; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D009395:Nephritis, Interstitial; D010630:Phenindione; D016896:Treatment Outcome; D014812:Vitamin K | Nephrologie & therapeutique | 2,008 | D000925:Anticoagulants; D004232:Diuretics; D014812:Vitamin K; D010630:Phenindione; C017673:fluindione |
Quantitative (13)C Solid-State NMR Spectra by Multiple-Contact Cross-polarization for Drug Delivery: From Active Principles to Excipients and Drug Carriers. | In this contribution, we present an analysis of the main parameters influencing the efficiency of the (1)H → (13)C multiple-contact cross-polarization nuclear magnetic resonance (NMR) experiment in the context of solid pharmaceutical materials. Using the optimum experimental conditions, quantitative (13)C NMR spectra a... | 27,372,550 | D001569:Benzodiazepines; D002247:Carbon Isotopes; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D002626:Chemistry, Pharmaceutical; D056831:Coordination Complexes; D004337:Drug Carriers; D005079:Excipients; D008715:Methionine; D000077152:Olanzapine; D004364:Pharmaceutical Preparations; D013395:Sucrose; D014633:Vali... | Journal of pharmaceutical sciences | 2,016 | D002247:Carbon Isotopes; D056831:Coordination Complexes; D004337:Drug Carriers; D005079:Excipients; D004364:Pharmaceutical Preparations; D001569:Benzodiazepines; D013395:Sucrose; D008715:Methionine; D014633:Valine; D000077152:Olanzapine | |
The surgical management of hyperparathyroidism and endocrine disease of the pancreas in the multiple endocrine neoplasia type 1 patient. | The surgical management of multiple endocrine neoplasia type 1 (MEN1) parathyroid disease and involvement of the endocrine pancreas remains controversial. Hyperparathyroidism, usually the first clinical manifestation of the syndrome, requires surgical treatment in nearly all patients. We favour a subtotal parathyroidec... | 10.1111/j.1365-2796.1995.tb00934.x | 7,673,858 | D000328:Adult; D000465:Algorithms; D004379:Duodenal Neoplasms; D005260:Female; D015408:Gastrinoma; D006801:Humans; D006961:Hyperparathyroidism; D007340:Insulinoma; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1; D010190:Pancreatic Neoplasms; D012189:Retrospective Studies; D015043:Zolling... | Journal of internal medicine | 1,995 | |
High throughput screening of a small molecule one-bead-one-compound combinatorial library to identify attenuators of p21 as chemotherapy sensitizers. | Kidney cancer is notoriously difficult to treat when metastatic due to its resistance to conventional chemotherapy. p21 is a cyclin kinase inhibitor which, in many tumor cell lines, conveys an antiapoptotic function through its induction by the DNA damage responsive p53 pathway, such that attenuation of p21 sensitizes ... | 10.4161/cbt.7.12.7069 | 18,981,726 | D014408:Biomarkers, Tumor; D001943:Breast Neoplasms; D002292:Carcinoma, Renal Cell; D045744:Cell Line, Tumor; D050759:Cyclin-Dependent Kinase Inhibitor p21; D004249:DNA Damage; D004317:Doxorubicin; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms | Cancer biology & therapy | 2,008 | D014408:Biomarkers, Tumor; C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D004317:Doxorubicin |
Demonstration of Near-Elimination of Hepatitis C Virus Among a Prison Population: The Lotus Glen Correctional Centre Hepatitis C Treatment Project. | Micro-elimination of hepatitis C virus (HCV) infection through rapid uptake of government-funded direct-acting antiviral therapy within an Australian prison setting is demonstrated. During a 22-month period, 119 patients initiated treatment for chronic HCV infection, with HCV in-prison viremic prevalence declining from... | 10.1093/cid/ciy210 | 29,538,639 | D000328:Adult; D000998:Antiviral Agents; D001315:Australia; D019698:Hepatitis C, Chronic; D006801:Humans; D008297:Male; D015995:Prevalence; D011329:Prisoners; D014766:Viremia | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | 2,018 | D000998:Antiviral Agents |
Health care costs and participation in a community-based health promotion program for older adults. | INTRODUCTION
EnhanceWellness (EW) is a community-based health promotion program that helps prevent disabilities and improves health and functioning in older adults. A previous randomized controlled trial demonstrated a decrease in inpatient use for EW participants but did not evaluate health care costs. We assessed the... | 20,158,966 | D000328:Adult; D000368:Aged; D003153:Community Health Services; D005260:Female; D015438:Health Behavior; D017048:Health Care Costs; D006293:Health Promotion; D006801:Humans; D008297:Male | Preventing chronic disease | 2,010 | ||
Relationship between health care insurance status, social determinants and prevalence of diabetes-related microvascular complications in patients with type 1 diabetes: a nationwide survey in Brazil. | AIMS
To evaluate the relationship between social determinants, health care insurance status and occurrence of diabetes-related chronic complications (DRCC) in Brazilian patients with type 1 diabetes.
METHODS
A multicenter cross-sectional study conducted between August 2011 and August 2014 in 14 public clinics in 10 B... | 10.1007/s00592-019-01308-7 | 30,868,316 | D000293:Adolescent; D000328:Adult; D000368:Aged; D001938:Brazil; D003922:Diabetes Mellitus, Type 1; D003930:Diabetic Retinopathy; D005260:Female; D006306:Health Surveys; D006801:Humans; D019458:Insurance Coverage; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D064890:Social Determinants of Health | Acta diabetologica | 2,019 | |
Oxidative imbalance and kidney damage in spontaneously hypertensive rats: activation of extrinsic apoptotic pathways. | In both humans and animals, essential hypertension acts as a risk factor for subclinical kidney damage and precedes renal dysfunction. Several lines of evidence indicate that hypertension and oxidative stress are closely related. The increase in vascular oxidative stress plays a key role in the pathophysiological conse... | 10.1042/CS20170177 | 28,495,910 | D000818:Animals; D000975:Antioxidants; D017209:Apoptosis; D004195:Disease Models, Animal; D000075222:Essential Hypertension; D051549:Glutathione S-Transferase pi; D006973:Hypertension; D007668:Kidney; D007674:Kidney Diseases; D015227:Lipid Peroxidation; D008099:Liver; D008297:Male; D018384:Oxidative Stress; D011918:Rat... | Clinical science (London, England : 1979) | 2,017 | D000975:Antioxidants; C000606292:Sod1 protein, rat; D000072105:Superoxide Dismutase-1; D051549:Glutathione S-Transferase pi; C496558:Gstp1 protein, rat |
Spontaneous splenic rupture in infectious mononucleosis. | Spontaneous splenic rupture is a rare but life-threatening complication of infectious mononucleosis. Abdominal pain and tachycardia are unusual in uncomplicated infectious mononucleosis and should alert a doctor to the possibility of spontaneous splenic rupture. | 10.1046/j.1035-6851.2001.00241.x | 11,554,870 | D000328:Adult; D006801:Humans; D007244:Infectious Mononucleosis; D008297:Male; D012422:Rupture, Spontaneous; D013161:Splenic Rupture | Emergency medicine (Fremantle, W.A.) | 2,001 | |
Lipopolysaccharide subtypes of Haemophilus influenzae type b from an outbreak of invasive disease. | Thirty isolates of Haemophilus influenzae type b were obtained during an outbreak of invasive H. influenzae type b disease and were classified by the electrophoretic profile of their lipopolysaccharide (LPS). The LPS was extracted by a rapid micromethod and analyzed by sodium dodecyl sulfate-polyacrylamide gel electrop... | 10.1128/jcm.20.2.145-150.1984 | 6,333,433 | D000328:Adult; D001425:Bacterial Outer Membrane Proteins; D002353:Carrier State; D002656:Child Day Care Centers; D002675:Child, Preschool; D004196:Disease Outbreaks; D004591:Electrophoresis, Polyacrylamide Gel; D006192:Haemophilus Infections; D006193:Haemophilus influenzae; D006801:Humans; D008070:Lipopolysaccharides; ... | Journal of clinical microbiology | 1,984 | D001425:Bacterial Outer Membrane Proteins; D008070:Lipopolysaccharides |
Meningeal management for optimal revascularization from middle meningeal artery. | Numerous surgical techniques have been developed and refined for the treatment of moyamoya disease. Among the indirect techniques of revascularization, encephaloduroarteriosynangiosis has been recognized as effective in promoting revascularization and reversing symptomatology. Neovascularization occurs between the dono... | 10.3171/2012.9.JNS112354 | 23,101,445 | D001921:Brain; D002548:Cerebral Revascularization; D004388:Dura Mater; D006801:Humans; D008576:Meningeal Arteries; D009072:Moyamoya Disease; D016896:Treatment Outcome | Journal of neurosurgery | 2,013 | |
Synthesis of water-soluble silicon-porphyrin: protolytic behaviour of axially coordinated hydroxy groups. | A new water-soluble silicon(IV)-tetra(4-carboxyphenyl)porphyrin (SiTCPP) with silicon(iv), the second most abundant element on Earth, in the center of porphyrin was synthesized. Fundamental properties including protolytic behaviour of axially coordinating hydroxy groups, and electrochemical behaviour were characterized... | 10.1039/c5dt03654b | 26,526,697 | D002384:Catalysis; D053138:Cyclohexenes; D055664:Electrochemical Techniques; D008958:Models, Molecular; D016877:Oxidants; D010084:Oxidation-Reduction; D010782:Photolysis; D011166:Porphyrins; D012825:Silicon; D012995:Solubility; D014867:Water | Dalton transactions (Cambridge, England : 2003) | 2,015 | D053138:Cyclohexenes; D016877:Oxidants; D011166:Porphyrins; D014867:Water; C052568:cyclohexene; D012825:Silicon |
Citrus aurantium Aroma for Anxiety in Patients with Acute Coronary Syndrome: A Double-Blind Placebo-Controlled Trial. | This study evaluated the antianxiety effect of Citrus aurantium aroma (neroli oil) inhalation on patients with acute coronary syndrome (ACS). A double-blind, placebo-controlled randomized trial. This study was conducted in the Coronary Care Unit of Torfeh Hospital in Tehran, Iran, from September 2017 to February 2018... | 10.1089/acm.2019.0061 | 31,211,612 | D054058:Acute Coronary Syndrome; D000368:Aged; D001007:Anxiety; D019341:Aromatherapy; D002957:Citrus; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008519:Medicine, Traditional; D008875:Middle Aged; D009822:Oils, Volatile | Journal of alternative and complementary medicine (New York, N.Y.) | 2,019 | D009822:Oils, Volatile |
The origin of the non-specialized epithelial cells cultured from human parotid gland. | We investigated the origin of the non-specialized cells proliferated in primary explant culture of human parotid gland. The predominant cells in surface layer were morphologically epithelial origin with desmosomes and intercellular digitations. The cultured cells did not show any specific affinity to parotin isolated f... | 10.1007/BF00665379 | 6,163,421 | D000681:Amylases; D002478:Cells, Cultured; D004247:DNA; D004847:Epithelial Cells; D006801:Humans; D007545:Isoproterenol; D010306:Parotid Gland; D012471:Salivary Proteins and Peptides | Archives of oto-rhino-laryngology | 1,981 | D012471:Salivary Proteins and Peptides; D004247:DNA; D000681:Amylases; D007545:Isoproterenol |
Protective effect of benzothiazole derivative KHG21834 on amyloid beta-induced neurotoxicity in PC12 cells and cortical and mesencephalic neurons. | We have investigated the effect of KHG21834, a benzothiazole derivative, on the amyloid beta protein (Abeta)-induced cell death in rat pheochromocytoma (PC12) cells and rat cortical and mesencephalic neuron-glia cultures. KHG21834 attenuated the Abeta(25-35)-induced apoptotic death in PC12 cells determined by character... | 10.1016/j.tox.2007.07.010 | 17,714,846 | D016229:Amyloid beta-Peptides; D000818:Animals; D000906:Antibodies; D017209:Apoptosis; D052160:Benzothiazoles; D015153:Blotting, Western; D002470:Cell Survival; D002478:Cells, Cultured; D002540:Cerebral Cortex; D053938:DNA Fragmentation; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D008636:Mesenceph... | Toxicology | 2,007 | D016229:Amyloid beta-Peptides; D000906:Antibodies; D052160:Benzothiazoles; C524157:KHG21834; D018696:Neuroprotective Agents; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35); D014446:Tyrosine 3-Monooxygenase; D048052:Mitogen-Activated Protein Kinase 3 |
[Effect of successive cyclic administration of oleandomycin and tetracycline on the immunogenic reactivity and indices of non-specific bodily resistance in experimental staphylococcal sepsis]. | The effect of subsequent cyclic administration of oleandomycin and tetracycline on the titer of the complement, the content of lysozyme, the bactericidal properties of the serum and the presence of the antibiotic specific antibodies in the blood serum found in the Hoigne reaction were studied on rabbits. It was found t... | 883,787 | D000818:Animals; D001770:Blood Bactericidal Activity; D002682:Chinchilla; D003165:Complement System Proteins; D004338:Drug Combinations; D009113:Muramidase; D009827:Oleandomycin; D011817:Rabbits; D018805:Sepsis; D013203:Staphylococcal Infections; D013752:Tetracycline | Antibiotiki | 1,977 | D004338:Drug Combinations; D003165:Complement System Proteins; D009113:Muramidase; D013752:Tetracycline; D009827:Oleandomycin | |
Phylogeny and S1 Gene Variation of Infectious Bronchitis Virus Detected in Broilers and Layers in Turkey. | The avian coronavirus infectious bronchitis virus (AvCoV-IBV) is recognized as an important global pathogen because new variants are a continuous threat to the poultry industry worldwide. This study investigates the genetic origin and diversity of AvCoV-IBV by analysis of the S1 sequence derived from 49 broiler flocks ... | 10.1637/11346-120915-Reg.1 | 27,610,718 | D000818:Animals; D036022:Capsid Proteins; D002645:Chickens; D018352:Coronavirus Infections; D014644:Genetic Variation; D001351:Infectious bronchitis virus; D010802:Phylogeny; D011201:Poultry Diseases; D060888:Real-Time Polymerase Chain Reaction; D017423:Sequence Analysis, RNA; D014421:Turkey | Avian diseases | 2,016 | D036022:Capsid Proteins |
Premature epiphyseal closure in a child receiving oral 13-cis-retinoic acid. | A boy with epidermolytic hyperkeratosis was treated systemically for 4 1/2 years with 13-cis-retinoic acid. At the age of 10 1/2 years, he developed pain in his right knee and radiographic evidence of partial closure of the proximal epiphysis of the right tibia. Similar radiographic changes have been described in indiv... | 10.1016/s0190-9622(82)70148-3 | 6,958,690 | D001847:Bone Diseases; D002648:Child; D004838:Epiphyses; D006801:Humans; D015474:Isotretinoin; D007642:Keratosis; D008297:Male; D013977:Tibia; D014212:Tretinoin | Journal of the American Academy of Dermatology | 1,982 | D014212:Tretinoin; D015474:Isotretinoin |
Antibiotic treatment for patients with amniotic fluid "sludge" to prevent spontaneous preterm birth: A historically controlled observational study. | INTRODUCTION
Amniotic fluid "sludge" has been associated with an increased rate of spontaneous preterm delivery before 35 weeks, a higher frequency of clinical and histologic chorioamnionitis in a high-risk population. Only one study evaluating the use of antibiotics in the presence of amniotic fluid "sludge" showed re... | 10.1111/aogs.13603 | 30,835,813 | D000328:Adult; D000653:Amniotic Fluid; D000900:Anti-Bacterial Agents; D001724:Birth Weight; D002821:Chorioamnionitis; D005260:Female; D006801:Humans; D007752:Obstetric Labor, Premature; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth; D016216:Ultrasonography, Prenatal | Acta obstetricia et gynecologica Scandinavica | 2,019 | D000900:Anti-Bacterial Agents |
A nonfucosylated anti-HER2 antibody augments antibody-dependent cellular cytotoxicity in breast cancer patients. | PURPOSE
Removal of fucose residues from the oligosaccharides of human antibody is a powerful approach to enhance antibody-dependent cellular cytotoxicity (ADCC), a potential important antitumor mechanism of therapeutic antibodies. To provide clinically relevant evidence of this mechanism, we investigated ADCC of a fuco... | 10.1158/1078-0432.CCR-06-1335 | 17,363,544 | D000328:Adult; D000368:Aged; D000818:Animals; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000920:Antibody-Dependent Cell Cytotoxicity; D001943:Breast Neoplasms; D016466:CHO Cells; D045744:Cell Line, Tumor; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D005643:Fucose; D006801:Hu... | Clinical cancer research : an official journal of the American Association for Cancer Research | 2,007 | D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; C496124:FCGR3A protein, human; D017452:Receptors, IgG; D005643:Fucose; D018719:Receptor, ErbB-2; D000068878:Trastuzumab |
Quantitative assessment of Fc receptor expression and function during in vitro differentiation of human monocytes to macrophages. | The expression and function of IgG Fc receptors on peripheral blood monocytes and monocytes differentiating in vitro, within hydrophobic membranes, to macrophages have been determined. Three characteristic functional stages could be discerned, and these were reflected in the surface expression of specific IgG binding s... | 2,940,169 | D002454:Cell Differentiation; D002478:Cells, Cultured; D004912:Erythrocytes; D006801:Humans; D007074:Immunoglobulin G; D008264:Macrophages; D009000:Monocytes; D010587:Phagocytosis; D011961:Receptors, Fc; D017452:Receptors, IgG; D011971:Receptors, Immunologic; D012397:Rosette Formation | Immunology | 1,986 | D007074:Immunoglobulin G; D011961:Receptors, Fc; D017452:Receptors, IgG; D011971:Receptors, Immunologic | |
Anti-Mullerian Hormone as a Marker of Ovarian Reserve and Function. | BACKGROUND
Ovarian reserve tests are required to screen women with a diminished ovarian reserve so that women who are more likely to exhibit poor response to ovarian stimulation and a lower likelihood of becoming pregnant with treatment can be identified.
AIM AND OBJECTIVES
This study aimed to determine whether serum... | 10.7759/cureus.29214 | 36,128,562 | Cureus | 2,022 | ||
Nanomaterials in Foods and Human Digestion: An Important Layer in the Assessment of Potential Toxic Effects. | The use of nanoparticles (e.g. titanium dioxide) in commercial food products to modify some properties, such as brightness and whiteness, increased in the last years and is nowadays widespread. Despite the inhalation of nanoparticles is already a topic of concern, the potential adverse health effects due to ingestion s... | 10.1007/978-3-030-88071-2_16 | 35,583,653 | D004063:Digestion; D005502:Food; D041981:Gastrointestinal Tract; D006801:Humans; D053758:Nanoparticles; D049329:Nanostructures | Advances in experimental medicine and biology | 2,022 | |
[Value of serum CA 19-9 determination in the diagnosis of pancreatic carcinoma]. | In this communication, serum Ca19-9 was determined in a series of patients with benign and malignant GI diseases. It was found that CA19-9 was positive in 86.7% of 30 pancreatic cancer patients with an average level of 427.53 u/ml, the value was statistically different from that found in non-malignant control group. Se... | 2,086,060 | D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms; D010195:Pancreatitis | Zhonghua wai ke za zhi [Chinese journal of surgery] | 1,990 | D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor | |
Brain infarction localized on left inferior temporal gyrus of presumed fetal onset. | Idiopathic perinatal cerebral infarction is recognized to be more common in the preterm infant than previously realized. However, the pathogenic mechanisms and the onset time remain unclear. We encountered an extremely low birth weight female infant with severe intrauterine growth retardation and brain infarction local... | 10.1111/j.1447-0756.2010.01266.x | 20,722,992 | D000328:Adult; D020520:Brain Infarction; D002585:Cesarean Section; D005260:Female; D005317:Fetal Growth Retardation; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases; D011247:Pregnancy; D013702:Temporal Lobe; D014463:Ultrasonography | The journal of obstetrics and gynaecology research | 2,010 | |
Metal Nanoparticles in Infection and Immunity. | Background Enthusiasm for the use of metal nanoparticles in human and veterinary medicine is high. Many articles describe the effects of metal nanoparticles on microbes in vitro, and a smaller number of articles describe effects on the immune system, which is the focus of this review. Methods Articles were retrieved by... | 10.1080/08820139.2020.1776724 | 32,524,902 | D000276:Adjuvants, Immunologic; D000818:Animals; D000900:Anti-Bacterial Agents; D015415:Biomarkers; D003141:Communicable Diseases; D004337:Drug Carriers; D016503:Drug Delivery Systems; D015195:Drug Design; D054884:Host-Pathogen Interactions; D006801:Humans; D007109:Immunity; D007113:Immunity, Innate; D007155:Immunologi... | Immunological investigations | 2,020 | D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D015415:Biomarkers; D004337:Drug Carriers; D007155:Immunologic Factors; D014612:Vaccines; D009569:Nitric Oxide |
Pulmonary vein and left atrial posterior wall isolation for the treatment of atrial fibrillation: Comparable outcomes for adults with congenital heart disease. | INTRODUCTION
Optimal treatment strategies for ACHD with AF are unknown. This study sought to assess outcomes of pulmonary vein isolation (PVI) ± left atrial (LA), posterior wall isolation (PWI) for adults with congenital heart disease (ACHD), and atrial fibrillation (AF).
METHODS
A retrospective review of all cryobal... | 10.1111/jce.15027 | 33,821,546 | D000328:Adult; D001281:Atrial Fibrillation; D017115:Catheter Ablation; D003452:Cryosurgery; D005260:Female; D006330:Heart Defects, Congenital; D006801:Humans; D008297:Male; D011667:Pulmonary Veins; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome | Journal of cardiovascular electrophysiology | 2,021 | |
[Device-aided therapies in advanced Parkinson's disease]. | Advanced stages of Parkinson's disease (PD) is a consequence of the severe neurodegenerative process and are characterized by the development of motor fluctuations and dyskinesia, aggravation of non-motor symptoms. Treatment with peroral and transdermal drugs can't provide an adequate control of PD symptoms and quality... | 10.17116/jnevro201611612154-60 | 28,139,627 | D000978:Antiparkinson Agents; D001058:Apomorphine; D002230:Carbidopa; D046690:Deep Brain Stimulation; D004338:Drug Combinations; D006801:Humans; D007263:Infusions, Parenteral; D055104:Infusions, Subcutaneous; D007583:Jejunum; D007980:Levodopa; D010300:Parkinson Disease | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | 2,016 | D000978:Antiparkinson Agents; D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa; D001058:Apomorphine |
Smartphone-Based Mobile Detection Platform for Molecular Diagnostics and Spatiotemporal Disease Mapping. | Rapid and quantitative molecular diagnostics in the field, at home, and at remote clinics is essential for evidence-based disease management, control, and prevention. Conventional molecular diagnostics requires extensive sample preparation, relatively sophisticated instruments, and trained personnel, restricting its us... | 10.1021/acs.analchem.8b00283 | 29,542,319 | D006678:HIV; D006801:Humans; D020407:Internet; D008163:Luminescent Measurements; D021141:Nucleic Acid Amplification Techniques; D061848:Optical Imaging; D057089:Pathology, Molecular; D000068997:Smartphone; D000071244:Zika Virus | Analytical chemistry | 2,018 | |
Improved procedure for lecithin/sphingomyelin ratio in amniotic fluid reduces false predictions of lung immaturity. | Many laboratories have found that their procedure for determining lecithin/sphingomyelin (L/S)ratios gives an unacceptably high proportion of false predictions of fetal lung immaturity. We investigated each step in the procedure, in an attempt to improve the clinical performance of the test and to make the method more ... | 7,055,955 | D000653:Amniotic Fluid; D002498:Centrifugation; D002855:Chromatography, Thin Layer; D003951:Diagnostic Errors; D005260:Female; D005325:Fetal Organ Maturity; D006801:Humans; D006819:Hyaline Membrane Disease; D007231:Infant, Newborn; D008168:Lung; D010713:Phosphatidylcholines; D010716:Phosphatidylinositols; D010718:Phosp... | Clinical chemistry | 1,982 | D010713:Phosphatidylcholines; D010716:Phosphatidylinositols; D010718:Phosphatidylserines; D013109:Sphingomyelins | |
[Improvement of the solubility behavior of problem drugs. 9. In vitro absorption studies using melting solidification products of iomeglamic acid]. | By means of the absorption apparatus according to Fürst and Neubert the solid dispersions of the iomeglamic acid were studied with regard to their in vitro absorption properties. All products showed better half lives of transport in relation to the pure compound. This was in correlation to the solubility parameters. | 3,575,388 | D000042:Absorption; D002626:Chemistry, Pharmaceutical; D005079:Excipients; D007462:Iodobenzenes; D010539:Permeability; D012995:Solubility | Die Pharmazie | 1,986 | D005079:Excipients; D007462:Iodobenzenes; C002060:iomeglamic acid | |
Are the salutogenic effects of social supports modified by income? A test of an "added value hypothesis". | Older adults (54 men, 113 women; M age = 69.5 years) were examined to test the hypothesis that social supports would be more salutogenic (health promoting) for persons with lower incomes than for persons with higher incomes. Interactions of income and social supports (mean of 3 emotional scales of the Interpersonal Sup... | 11,403,213 | D000368:Aged; D000375:Aging; D001794:Blood Pressure; D015992:Body Mass Index; D008076:Cholesterol, HDL; D003866:Depressive Disorder; D002149:Energy Intake; D015444:Exercise; D005260:Female; D015438:Health Behavior; D006304:Health Status; D006801:Humans; D007182:Income; D007398:Interpersonal Relations; D007694:Killer Ce... | Health psychology : official journal of the Division of Health Psychology, American Psychological Association | 2,001 | D008076:Cholesterol, HDL | |
Serum soluble Fas levels in preeclampsia. | OBJECTIVE
To determine if serum soluble Fas levels are altered in women with preeclampsia.
METHODS
Thirty-four pregnant women with preeclampsia and 34 normotensive pregnant women were studied. Subjects were matched as much as possible for demographics. Preeclampsia was defined as proteinuric hypertension. Serum solub... | 10.1016/s0029-7844(00)01227-8 | 11,275,023 | D000328:Adult; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia; D011247:Pregnancy; D019014:fas Receptor | Obstetrics and gynecology | 2,001 | D019014:fas Receptor |
Design and fabrication of novel stretchable device arrays on a deformable polymer substrate with embedded liquid-metal interconnections. | Stretchable devices are fabricated on a newly designed deformable substrate. Active devices attached on the stiff islands are electrically connected by an embedded EGaIn interconnection, which ensures protection from external damage. In this structure, the local strain in the active device area is estimated to be less ... | 10.1002/adma.201402588 | 25,159,006 | Advanced materials (Deerfield Beach, Fla.) | 2,014 | ||
Malaria in travellers: epidemiology and prevention. | Malaria continues to be a serious health risk for travellers. The malaria parasites which infect humans can only be naturally transmitted by female mosquitoes of the genus Anopheles. Travellers to malaria endemic areas require detailed advice on appropriate chemoprophylaxis against malaria and personal protection again... | 10.1093/oxfordjournals.bmb.a072615 | 8,334,497 | D000962:Antimalarials; D006266:Health Education; D006801:Humans; D008288:Malaria; D009032:Mosquito Control; D010349:Patient Compliance; D014195:Travel | British medical bulletin | 1,993 | D000962:Antimalarials |
Intracranial Myxoid Mesenchymal Tumor With EWSR1-ATF1 Fusion. | Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor that arises primarily in the extremities of young adults. Recurrent gene fusions involving EWSR1 with members of the cAMP response element binding protein (CREB) family have been reported in a diverse group of tumors, including AFH. AFH-like lesions hav... | 10.1093/jnen/nlz140 | 32,016,322 | D051697:Activating Transcription Factor 1; D000368:Aged; D001932:Brain Neoplasms; D050939:Gene Fusion; D051677:Histiocytoma, Malignant Fibrous; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells; D009232:Myxoma; D034802:RNA-Binding Protein EWS | Journal of neuropathology and experimental neurology | 2,020 | C531110:ATF1 protein, human; D051697:Activating Transcription Factor 1; C500986:EWSR1 protein, human; D034802:RNA-Binding Protein EWS |
[The effect of a mixture of bacterial ribosomes and membrane fractions of Klebsiella pneumoniae on the development of a transplanted epithelial cancer in rats]. | An association of bacterial ribosomes and cell-wall of Klebsiella pneumoniae was shown to reduce the incidence of an epidermoid carcinoma in Sprague-Dawley rats when administered subcutaneously prior the tumoral graft. Mononuclear cells accumulate around the tumor. This association was considered as a non specific adju... | 145,286 | D000276:Adjuvants, Immunologic; D000818:Animals; D001428:Bacterial Vaccines; D002294:Carcinoma, Squamous Cell; D002473:Cell Wall; D005260:Female; D007711:Klebsiella pneumoniae; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D010457:Peptidoglycan; D051381:Rats; D012270:Ribosomes | Comptes rendus des seances de la Societe de biologie et de ses filiales | 1,977 | D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D010457:Peptidoglycan | |
Katanin contributes to interspecies spindle length scaling in Xenopus. | Bipolar spindles must separate chromosomes by the appropriate distance during cell division, but mechanisms determining spindle length are poorly understood. Based on a 2D model of meiotic spindle assembly, we predicted that higher localized microtubule (MT) depolymerization rates could generate the shorter spindles ob... | 10.1016/j.cell.2011.11.014 | 22,153,081 | D000251:Adenosine Triphosphatases; D000595:Amino Acid Sequence; D000818:Animals; D002457:Cell Extracts; D006801:Humans; D000074201:Katanin; D008870:Microtubules; D008969:Molecular Sequence Data; D053141:Organelle Size; D010766:Phosphorylation; D016415:Sequence Alignment; D013045:Species Specificity; D008941:Spindle App... | Cell | 2,011 | D002457:Cell Extracts; D000251:Adenosine Triphosphatases; D000074201:Katanin |
Crop dusting or composting? | In the education and training realm of psychiatric rehabilitation, this article uses a composting/crop-dusting metaphor to describe a competency-based framework of staff development. The crop-dusting, or "fly over," approach to training is likened to an aerial dump of information that may have some positive effect on g... | 10.1037/prj0000017 | 24,059,634 | D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D033181:Information Dissemination; D007318:Inservice Training; D009936:Organizational Innovation; D009938:Organizations | Psychiatric rehabilitation journal | 2,013 | |
[Present problems of somatic cell genetics]. | A review of recent advances in genetics of somatic cells is given in the article. It contains three sections: 1) hybridization of somatic cells and its application to the mapping of genes and to the study of gene action; 2) relation of somatic cell genetics to genetic engineerings; 3) progress and perspectives of highe... | 176,083 | D000818:Animals; D002459:Cell Fusion; D002874:Chromosome Mapping; D003182:Complement C5; D005796:Genes; D005809:Genes, Regulator; D005818:Genetic Engineering; D007621:Karyotyping; D008545:Melanoma; D010944:Plants; D018139:Simplexvirus; D014170:Transformation, Genetic | Genetika | 1,975 | D003182:Complement C5 | |
Effects of epsilon aminocaproic acid on primary hemostasis. | These studies examined the effect of an oral dose of epsilon-aminocaproic acid (EACA) on primary hemostasis. Bleeding time tests (with and without the use of a blood pressure cuff) were measured before and 2 h following EACA in 56 patients with mild bleeding disorders and/or thrombocytopenia. Preliminary studies evalua... | 10.1159/000216242 | 1,806,460 | D000284:Administration, Oral; D015119:Aminocaproic Acid; D001760:Bleeding Time; D001778:Blood Coagulation Disorders; D006487:Hemostasis; D006801:Humans; D008103:Liver Cirrhosis; D009436:Neural Tube Defects; D014511:Uremia | Haemostasis | 1,991 | D015119:Aminocaproic Acid |
Cerebral embolisation during modern cardiopulmonary bypass. | OBJECTIVES
Cerebral microembolisation still occurs during cardiopulmonary bypass and may cause both stroke and postoperative cognitive impairment. We investigated the frequency of cerebral embolisation during coronary artery bypass surgery with modern cardiopulmonary bypass and related these to ascending aortic atheros... | 10.1016/s1010-7940(01)00981-2 | 11,717,022 | D000328:Adult; D000368:Aged; D001018:Aortic Diseases; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D020766:Intracranial Embolism; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D017585:Ultrasonography, Doppl... | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery | 2,001 | |
Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin. | The in vitro antitumor activity of a novel ginseng saponin metabolite, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (IH-901), was examined against four human cancer cell lines and one subline resistant to cisplatin (CDDP). The growth inhibitory activity of the compound was estimated by MTT tetrazolium assay. The me... | 10.1016/s0304-3835(99)00188-3 | 10,503,876 | D000230:Adenocarcinoma; D000970:Antineoplastic Agents; D002945:Cisplatin; D019008:Drug Resistance, Neoplasm; D036145:Ginsenosides; D006801:Humans; D008175:Lung Neoplasms; D012503:Saponins; D014315:Triterpenes; D014407:Tumor Cells, Cultured | Cancer letters | 1,999 | D000970:Antineoplastic Agents; D036145:Ginsenosides; D012503:Saponins; D014315:Triterpenes; C112772:ginsenoside M1; D002945:Cisplatin |
The right ventricular outflow tract in patients with suspected arrhythmogenic right ventricular cardiomyopathy referred for cardiac magnetic resonance imaging. | OBJECTIVES
To determine if right ventricular outflow tract dilatation occurs in patients with a clinical suspicion of arrhythmogenic right ventricular dysplasia.
METHODS
Fifty patients referred to us with a clinical suspicion of arrhythmogenic right ventricular dysplasia underwent cardiac magnetic resonance imaging. ... | 18,551,919 | D019571:Arrhythmogenic Right Ventricular Dysplasia; D006352:Heart Ventricles; D006801:Humans; D008279:Magnetic Resonance Imaging; D012189:Retrospective Studies; D014694:Ventricular Outflow Obstruction | Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology | 2,008 | ||
Fludrocortisone Induces Aortic Pathologies in Mice. | BACKGROUND AND OBJECTIVE
In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was to investigate whether fludrocortisone induces aortic pathologies in both normocho... | 10.3390/biom12060825 | 35,740,952 | D000804:Angiotensin II; D000818:Animals; D001012:Aorta, Abdominal; D004121:Dimethyl Sulfoxide; D004195:Disease Models, Animal; D005438:Fludrocortisone; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D000074085:Mice, Knockout, ApoE; D011973:Receptors, LDL | Biomolecules | 2,022 | D011973:Receptors, LDL; D000804:Angiotensin II; D005438:Fludrocortisone; D004121:Dimethyl Sulfoxide |
Nomogram Model for Predicting Risk of Postoperative Delirium After Deep Brain Stimulation Surgery in Patients Older Than 50 Years with Parkinson Disease. | OBJECTIVE
To explore the influencing factors of postoperative delirium (POD) after deep brain electric stimulation (DBS) in patients older than 50 years with Parkinson disease (PD) and to construct a nomogram model to predict the risk of POD.
METHODS
A retrospective cohort study was conducted of 229 patients older th... | 10.1016/j.wneu.2020.03.160 | 32,302,731 | D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D046690:Deep Brain Stimulation; D003693:Delirium; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D049451:Nomograms; D010300:Parkinson Disease; D011183:Postoperative Complications; D012189:Retrospective Studies; D0123... | World neurosurgery | 2,020 | |
Aerobic exercise + weight loss decreases skeletal muscle myostatin expression and improves insulin sensitivity in older adults. | OBJECTIVE
To determine whether aerobic exercise training + weight loss (AEX + WL) would affect the expression of myostatin and its relationship with insulin sensitivity in a longitudinal, clinical intervention study.
DESIGN AND METHODS
Thirty-three obese sedentary postmenopausal women and men (n = 17 and 16, age: 61 ... | 10.1002/oby.20216 | 23,687,104 | D000368:Aged; D001786:Blood Glucose; D015992:Body Mass Index; D001835:Body Weight; D015536:Down-Regulation; D015444:Exercise; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin; D007333:Insulin Resistance; D008019:Life Style; D008137:Longitudinal Studies; D008297:Male; D008... | Obesity (Silver Spring, Md.) | 2,013 | D001786:Blood Glucose; D007328:Insulin; C525911:MSTN protein, human; D055435:Myostatin |
One-step (18)F labeling of non-peptidic bivalent integrin αvβ3 antagonist for cancer imaging. | A rapid one-step (18)F labeling reaction with fluoridealuminum complex, which is based on chelation chemistry, has received a surge of interest for (18)F radiolabeling of peptides. In this study, a non-peptidic bivalent integrin αvβ3 antagonist (bivalent-IA) was conjugated with 1,4,7-triazacyclononane-1,4-diiacetic aci... | 10.1021/bc500590f | 25,551,189 | D000818:Animals; D045744:Cell Line, Tumor; D005462:Fluorine Radioisotopes; D006571:Heterocyclic Compounds; D006801:Humans; D039302:Integrin alphaVbeta3; D007553:Isotope Labeling; D051379:Mice; D049268:Positron-Emission Tomography; D011854:Radiochemistry; D019275:Radiopharmaceuticals; D014018:Tissue Distribution; D01405... | Bioconjugate chemistry | 2,015 | C519451:1,4,7-triazacyclononane-1,4-diacetate; D005462:Fluorine Radioisotopes; D006571:Heterocyclic Compounds; D039302:Integrin alphaVbeta3; D019275:Radiopharmaceuticals |
Development of an antibody against a 40,000 mol. wt brain injury-derived neurotrophic peptide-binding protein and identification of a 40,000 mol. wt brain injury-derived neurotrophic peptide-binding protein in hippocampal neurons. | Brain injury-derived neurotrophic peptide is a 13-amino acid peptide derived from a 15,000 mol. wt neurotrophic factor released from sites of mechanical injury in neonatal rat brain. This peptide promotes survival of septal cholinergic neurons and mesencephalic dopaminergic neurons, and protects hippocampal neurons fro... | 10.1016/s0306-4522(00)00136-6 | 10,869,850 | D000818:Animals; D000911:Antibodies, Monoclonal; D016923:Cell Death; D003432:Cross-Linking Reagents; D003470:Culture Media; D005333:Fetus; D018698:Glutamic Acid; D006624:Hippocampus; D006825:Hybridomas; D007457:Iodine Radioisotopes; D051379:Mice; D008970:Molecular Weight; D009419:Nerve Tissue Proteins; D009447:Neurobla... | Neuroscience | 2,000 | D000911:Antibodies, Monoclonal; D003432:Cross-Linking Reagents; D003470:Culture Media; D007457:Iodine Radioisotopes; D009419:Nerve Tissue Proteins; C102215:brain injury-derived neurotrophic peptide; D018698:Glutamic Acid |
Online public interest in common malignancies and cancer screening during the COVID-19 pandemic in the United States. | BACKGROUND AND AIM
The COVID-19 pandemic was declared a national emergency in the United States in March 2020. The Centers for Medicare and Medicaid Services subsequently released recommendations that health-care facilities temporarily delay elective surgeries and non-essential medical procedures. Disruptions to medica... | 34,901,518 | Journal of clinical and translational research | 2,021 | |||
A quality assurance program for the on-board imagers. | To develop a quality assurance (QA) program for the On-Board Imager (OBI) system and to summarize the results of these QA tests over extended periods from multiple institutions. Both the radiographic and cone-beam computed tomography (CBCT) mode of operation have been evaluated. The QA programs from four institutions h... | 10.1118/1.2362872 | 17,153,422 | D019544:Equipment Failure Analysis; D011785:Quality Assurance, Health Care; D020266:Radiotherapy, Conformal; D013813:Therapy, Computer-Assisted; D014057:Tomography, X-Ray Computed; D014481:United States | Medical physics | 2,006 | |
Mid-infrared spectrometer using opto-nanofluidic slot-waveguide for label-free on-chip chemical sensing. | A mid-infrared (mid-IR) spectrometer for label-free on-chip chemical sensing was developed using an engineered nanofluidic channel consisting of a Si-liquid-Si slot-structure. Utilizing the large refractive index contrast (Δn ∼ 2) between the liquid core of the waveguide and the Si cladding, a broadband mid-IR lightwav... | 10.1021/nl403817z | 24,328,355 | D002623:Chemistry Techniques, Analytical; D004867:Equipment Design; D019544:Equipment Failure Analysis; D046228:Microarray Analysis; D008832:Microchemistry; D046210:Microfluidic Analytical Techniques; D036103:Nanotechnology; D013055:Spectrophotometry, Infrared; D013194:Staining and Labeling; D020349:Surface Plasmon Res... | Nano letters | 2,014 |
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