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A novel biological 'twin-father' temporal paradox of General Relativity in a Gödel universe - Where reproductive biology meets theoretical physics. | Several temporal paradoxes exist in physics. These include General Relativity's grandfather and ontological paradoxes and Special Relativity's Langevin-Einstein twin-paradox. General relativity paradoxes can exist due to a Gödel universe that follows Gödel's closed timelike curves solution to Einstein's field equations... | 10.1016/j.pbiomolbio.2017.10.004 | 29,079,208 | D001695:Biology; D010825:Physics; D012098:Reproduction | Progress in biophysics and molecular biology | 2,018 | |
VAS2870 Inhibits Histamine-Induced Calcium Signaling and vWF Secretion in Human Umbilical Vein Endothelial Cells. | In this study, we investigated the effects of NAD(P)H oxidase (NOX) inhibitor VAS2870 (3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine) on the histamine-induced elevation of free cytoplasmic calcium concentration ([Ca2+]i) and the secretion of von Willebrand factor (vWF) in human umbilical vein endothel... | 10.3390/cells8020196 | 30,813,397 | D000818:Animals; D001011:Aorta; D001583:Benzoxazoles; D020013:Calcium Signaling; D006632:Histamine; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008297:Male; D009638:Norepinephrine; D010084:Oxidation-Reduction; D010446:Peptide Fragments; D017208:Rats, Wistar; D017382:Reactive Oxygen Species; D014230... | Cells | 2,019 | C511179:3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine; D001583:Benzoxazoles; D010446:Peptide Fragments; D017382:Reactive Oxygen Species; D014230:Triazoles; C082835:thrombin receptor peptide (42-47); D014841:von Willebrand Factor; D006632:Histamine; D009638:Norepinephrine |
Metagenomic analysis of viromes of dromedary camel fecal samples reveals large number and high diversity of circoviruses and picobirnaviruses. | The recent discovery of Middle East Respiratory Coronavirus and another novel dromedary camel coronavirus UAE-HKU23 in dromedaries has boosted interest in search of novel viruses in dromedaries. In this study, fecal samples of 203 dromedaries in Dubai were pooled and deep sequenced. Among the 7330 assembled viral conti... | 25,461,537 | D000818:Animals; D002162:Camelus; D017925:Circovirus; D005243:Feces; D014644:Genetic Variation; D056186:Metagenomics; D010802:Phylogeny; D018708:Picobirnavirus | Virology | 2,014 | ||
Comparative three-dimensional analysis of initial biofilm formation on three orthodontic bracket materials. | INTRODUCTION
The purpose of the present study was to investigate and compare early biofilm formation on biomaterials, which are being used in contemporary fixed orthodontic treatment.
METHODS
This study comprised 10 healthy volunteers (5 females and 5 males) with a mean age of 27.3 +-3.7 years. Three slabs of differe... | 10.1186/s13005-015-0062-0 | 25,889,778 | D000328:Adult; D018441:Biofilms; D002516:Ceramics; D005260:Female; D006046:Gold; D064368:Healthy Volunteers; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008422:Materials Testing; D018613:Microscopy, Confocal; D016910:Orthodontic Brackets; D009970:Orthodontics; D012494:Sampling Studies; D012680:Se... | Head & face medicine | 2,015 | D013193:Stainless Steel; D006046:Gold |
Nutritional effects on heart acetylcholinesterase and butyrocholinesterase activity. | Male rat pups were undernourished in energy and protein by assigning them at birth to lactating dams receiving a low-protein diet (12% casein) to decrease the maternal milk supply. A normal diet (25% casein) was fed to the dams of control pups. On day 21 the pups were killed and hearts were removed and examined from bo... | 10.1152/ajplegacy.1975.229.6.1532 | 1,211,485 | D000110:Acetylcholinesterase; D000818:Animals; D002091:Butyrylcholinesterase; D002364:Caseins; D002795:Choline O-Acetyltransferase; D002802:Cholinesterases; D004038:Diet, Reducing; D004044:Dietary Proteins; D008297:Male; D009206:Myocardium; D011488:Protein Deficiency; D051381:Rats | The American journal of physiology | 1,975 | D002364:Caseins; D004044:Dietary Proteins; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D002802:Cholinesterases |
Kynureninase-type enzymes and the evolution of the aerobic tryptophan-to-nicotinamide adenine dinucleotide pathway. | Kynureninase-type (L-kynurenine hydrolase, EC 3.7.1.3) activity has been found to be present in the livers of fish, amphibia, reptiles, and birds. In addition to past information concerning this enzyme activity in mammalian liver, it is now clear that all the major classes of vertebrates carry a highly specialized kynu... | 10.1016/0005-2744(77)90259-5 | 195,620 | D000818:Animals; D001001:Anura; D005075:Biological Evolution; D002645:Chickens; D005658:Fungi; D006867:Hydrolases; D007737:Kynurenine; D008099:Liver; D051379:Mice; D009243:NAD; D011551:Pseudomonas fluorescens; D013045:Species Specificity; D014337:Trout; D014364:Tryptophan; D014426:Turtles; D014974:Xanthomonas | Biochimica et biophysica acta | 1,977 | D009243:NAD; D007737:Kynurenine; D014364:Tryptophan; D006867:Hydrolases; C021480:kynureninase |
Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides. | The function of p53 is modulated by binding to a number of cellular and viral proteins, such as MDM2 and SV40 large T antigen. An initial immunochemical characterization of the p53-MDM2 complex in a rat fibroblast cell line (Clone 6) suggested that the anti-p53 monoclonal antibody Bp53-19 failed to immunoprecipitate th... | 8,058,315 | D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002478:Cells, Cultured; D007120:Immunochemistry; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D010446:Peptide Fragments; D011518:Proto-Oncogene Proteins; D051736:Proto-Oncogene Prot... | Oncogene | 1,994 | D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D010446:Peptide Fragments; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; C497207:Mdm2 protein, mouse; D051736:Proto-Oncogene Proteins c-mdm2 | |
The use of veno-venous extracorporeal membrane oxygenation for massive hemoptysis following a traumatic lung injury: a case report. | BACKGROUND
Published reports regarding the use of veno-venous extracorporeal membrane oxygenation (V-V ECMO) for massive hemoptysis following a thoracic injury are still scarce.
CASE PRESENTATION
A 34-year-old man developed massive hemoptysis from the right lung after a 2 m fall and being compressed with an iron pipe... | 10.1002/ams2.492 | 32,509,313 | Acute medicine & surgery | 2,020 | ||
Nanomeshes with Sub-10 nm Pores by Glycerol-Triggered 2D Assembly in Liquid Phases for Fast and Selective Membranes. | Nanomeshes having ultrathin thicknesses and penetrating nanopores promise fast diffusion and precise selectivity and are highly desired in diffusion-involved processes such as separation. Herein, we report a liquid-phase two-dimensional (2D) assembly strategy to synthesize phenolic and carbonaceous nanomeshes with sub-... | 10.1021/acs.nanolett.1c00826 | 33,792,318 | Nano letters | 2,021 | ||
Listeria meningoencephalitis: two cases and a review of the literature. | INTRODUCTION
Although presently uncommon locally, Listeria is increasing an important cause of central nervous system (CNS) infection worldwide. It differs from the common meningitis pathogens in its clinical features and treatment.
CLINICAL PICTURE
We present 2 recently encountered cases of Listeria meningoencephali... | 11,817,300 | D000328:Adult; D000900:Anti-Bacterial Agents; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D006849:Hydrocephalus; D008089:Listeria monocytogenes; D008297:Male; D008584:Meningitis, Listeria; D008875:Middle Aged; D012640:Seizures | Annals of the Academy of Medicine, Singapore | 2,001 | D000900:Anti-Bacterial Agents | |
Maternal homocysteine levels and plasma lipids in gestational diabetes: is there any relationship? | The aim of the study was to investigate the possible relationship between maternal homocysteine levels and plasma lipid parameters and whether gestational diabetes can alter the serum maternal concentration of this substance. The study included 36 primigravidas divided into two groups: group A consisted of 21 healthy p... | 10.1080/01443610220141272 | 12,521,455 | D000328:Adult; D015415:Biomarkers; D016022:Case-Control Studies; D002784:Cholesterol; D008078:Cholesterol, LDL; D016640:Diabetes, Gestational; D005260:Female; D006710:Homocysteine; D006801:Humans; D010298:Parity; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D014280:Triglycerides | Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology | 2,002 | D015415:Biomarkers; D008078:Cholesterol, LDL; D014280:Triglycerides; D006710:Homocysteine; D002784:Cholesterol |
Median cysts of the jaws--not a true clinical entity. | The so-called median cysts of the jaws (median mandibular and median palatine) are currently classified as fissural cysts. Their existence as distinct clinical and histological entities has been the cause of debate. It is the purpose of this paper to point out that from present evidence in published case reports and re... | 10.1016/s0300-9785(82)80059-8 | 6,820,008 | D006801:Humans; D008336:Mandibular Diseases; D008439:Maxillary Diseases; D009631:Nonodontogenic Cysts; D010159:Palate | International journal of oral surgery | 1,982 | |
The predominant drug-specific T-cell population may switch from cytotoxic T cells to regulatory T cells during the course of anticonvulsant-induced hypersensitivity. | BACKGROUND
Delayed hypersensitivity is responsible for severe cutaneous adverse drug reactions (cADRs), especially in Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis, and drug-induced hypersensitivity syndrome (DIHS) (also known as drug rash with eosinophilia and systemic symptoms [DRESS] syndrome). The drug... | 10.1016/j.jdermsci.2011.12.002 | 22,226,608 | D000328:Adult; D000368:Aged; D000927:Anticonvulsants; D018414:CD8-Positive T-Lymphocytes; D016022:Case-Control Studies; D049109:Cell Proliferation; D002478:Cells, Cultured; D004802:Eosinophilia; D005076:Exanthema; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D006968:Hypersensitivity, Delayed; D007963:Leukocy... | Journal of dermatological science | 2,012 | D000927:Anticonvulsants |
Helping policy-makers address rural health access problems. | This paper provides a comprehensive review of the key dimensions of access and their significance for the provision of primary health care and a framework that assists policy-makers to evaluate how well policy targets the dimensions of access. Access to health care can be conceptualised as the potential ease with which... | 10.1111/ajr.12023 | 23,586,567 | D001315:Australia; D006297:Health Services Accessibility; D006801:Humans; D011050:Policy Making; D011320:Primary Health Care; D019035:Rural Health Services | The Australian journal of rural health | 2,013 | |
Serological evidence of altered collagen homeostasis reflects early ventricular remodeling following acute myocardial infarction. | BACKGROUND
Infarct expansion characterises early ventricular remodeling following myocardial infarction (AMI) and is a product of the balance between collagen degradation and synthesis. Serological markers of collagen turnover may help in predicting those at risk of remodeling. C-propeptide for type-I collagen (PICP) a... | 10.1016/j.ijcard.2005.08.045 | 16,297,470 | D015415:Biomarkers; D001794:Blood Pressure; D003094:Collagen; D004562:Electrocardiography; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left; D020257:Ventricular Remodeling | International journal of cardiology | 2,006 | D015415:Biomarkers; D003094:Collagen |
Preparation of genomic DNA from mammalian tissue. | There are a number of different procedures for the preparation of genomic DNA. They all start with some form of cell lysis, followed by deproteination and recovery of DNA. The main differences between various approaches lie in the extent of deproteination and in molecular weight of the DNA produced. The isolation proce... | 10.1002/0471142301.nsa01hs06 | 18,428,439 | D000818:Animals; D002458:Cell Fractionation; D004247:DNA; D008322:Mammals; D012995:Solubility; D012997:Solvents | Current protocols in neuroscience | 2,001 | D012997:Solvents; D004247:DNA |
Translating whole-body cryotherapy into geriatric psychiatry--a proposed strategy for the prevention of Alzheimer's disease. | Alzheimer's disease (AD), which is the most common form of dementia, constitutes one of the leading causes of disability and mortality in aging societies. Currently recommended medications used in treating AD include cholinesterase inhibitors and the NMDA antagonist--memantine, but poorly counteract progression of the ... | 10.1016/j.mehy.2012.03.033 | 22,541,861 | D000544:Alzheimer Disease; D017679:Cryotherapy; D006801:Humans; D008962:Models, Theoretical | Medical hypotheses | 2,012 | |
Professional dental education ... the beginnings. | From very humble beginnings, professional dental education for the world began in 1840 at the Baltimore College of Dental Surgery, the site of the 46th meeting of the American Academy of the History of Dentistry. Most all countries today have professional dental education facilities or require formalized professional e... | 9,709,667 | D015142:Baltimore; D004497:Education, Dental; D049672:History, 19th Century; D012575:Schools, Dental; D014481:United States | Journal of the history of dentistry | 1,998 | ||
Direction selectivity in the retina: symmetry and asymmetry in structure and function. | Visual information is processed in the retina to a remarkable degree before it is transmitted to higher visual centres. Several types of retinal ganglion cells (the output neurons of the retina) respond preferentially to image motion in a particular direction, and each type of direction-selective ganglion cell (DSGC) i... | 10.1038/nrn3165 | 22,314,444 | D000200:Action Potentials; D025042:Amacrine Cells; D000818:Animals; D003712:Dendrites; D006801:Humans; D010775:Photic Stimulation; D012160:Retina; D012165:Retinal Ganglion Cells; D013569:Synapses; D014795:Visual Pathways; D014796:Visual Perception | Nature reviews. Neuroscience | 2,012 | |
Dietary glycemic load and glycemic index and risk of cerebrovascular disease in the EPICOR cohort. | BACKGROUND
Studies on the association of stroke risk to dietary glycemic index (GI) and glycemic load (GL) have produced contrasting results.
OBJECTIVE
To investigate the relation of dietary GI and GL to stroke risk in the large EPIC-Italy cohort (EPICOR) recruited from widely dispersed geographic areas of Italy.
D... | 10.1371/journal.pone.0062625 | 23,717,392 | D000328:Adult; D000368:Aged; D002545:Brain Ischemia; D015331:Cohort Studies; D004032:Diet; D004040:Dietary Carbohydrates; D005260:Female; D038321:Glycemic Index; D006801:Humans; D015994:Incidence; D020300:Intracranial Hemorrhages; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Ha... | PloS one | 2,013 | D004040:Dietary Carbohydrates |
[Psychophysiologic and psychoneuroimmunologic studies in neurodermatitis. Overview and critical evaluation]. | Results of psychophysiological, psychoendocrinological, and psychoneuroimmunological research on the skin in patients with atopic dermatitis were evaluated. 11 investigations were selected and analysed with respect to both design and results. In 6 instances, healthy or ill control groups were included, rarely did the s... | 10.1007/s001050050539 | 9,132,389 | D000293:Adolescent; D000328:Adult; D001143:Arousal; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009450:Neurodermatitis; D011602:Psychophysiologic Disorders; D012867:Skin; D013001:Somatoform Disorders; D013315:Stress, Psychological | Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete | 1,997 | |
Industrial hygiene in a newly industrialized country - South Korea. | The Yant Award was established in 1964 to honor the contributions of William P. Yant, the first president of the American Industrial Hygiene Association. It is presented annually for outstanding contributions in industrial hygiene or allied fields to an individual residing outside the United States. | 10.1080/15459620701728346 | 17,987,488 | D001363:Awards and Prizes; D019049:Developed Countries; D049673:History, 20th Century; D007723:Korea; D016272:Occupational Health; D012958:Societies, Scientific | Journal of occupational and environmental hygiene | 2,008 | |
Coronary arteriovenous fistula secondary to percutaneous coronary intervention of chronic total occlusion. | This is a case report of a 61-year-old female presenting with ongoing chest pain in the setting of an NSTEMI with lateral ST-T changes. On attempting to open the left circumflex (LCX), it resulted in a proximal LCX dissection. The patient remained stable with no further chest pain. She was treated with IV Eptifibatide ... | 10.1155/2013/706820 | 23,864,982 | Case reports in vascular medicine | 2,013 | ||
Effect of adjuvant chemotherapy on survival in FNCLCC grade 3 soft tissue sarcomas: a multivariate analysis of the French Sarcoma Group Database. | BACKGROUND
The predictive value of grade for benefit from adjuvant chemotherapy (AC) in soft tissue sarcoma (STS) patients has never been explored.
PATIENTS AND METHODS
From 1980 to 1999, 1513 adult patients with non-metastatic STS were included prospectively in the French Sarcoma Group database. Grade was assessed a... | 10.1093/annonc/mdq238 | 20,439,343 | D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D016208:Databases, Factual; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012107:Research Design; D012509:Sarcoma; D016019:Survival Analysis; D... | Annals of oncology : official journal of the European Society for Medical Oncology | 2,010 | |
Intestinal blood-flow velocity in uncomplicated preterm infants during the early neonatal period. | BACKGROUND
Intestinal blood-flow changes after birth. Objective. To elucidate the factors influencing intestinal blood-flow velocity in preterm infants during the early neonatal period.
MATERIALS AND METHODS
We measured blood-flow velocity in the superior mesenteric artery by pulsed Doppler US in 44 uncomplicated inf... | 10.1007/s002470050621 | 10,369,910 | D000375:Aging; D001724:Birth Weight; D001783:Blood Flow Velocity; D001794:Blood Pressure; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007422:Intestines; D008297:Male; D018617:Ultrasonography, Doppler, Pulsed; D014655:Vascular Resistance | Pediatric radiology | 1,999 | |
Memory for emotional pictures in patients with Alzheimer's dementia: comparing picture-location binding and subsequent recognition. | Emotional content typically facilitates subsequent memory, known as the emotional enhancement effect. We investigated whether emotional content facilitates spatial and item memory in patients with Alzheimer's dementia (AD). Twenty-three AD patients, twenty-three healthy elderly, and twenty-three young adults performed ... | 10.4061/2011/409364 | 21,822,492 | Journal of aging research | 2,011 | ||
Chorioamnionitis in the pathogenesis of brain injury in preterm infants. | Chorioamnionitis (or placental infection) is suspected to be a risk factor for brain injury in premature infants. The suggested association between chorioamnionitis and cystic periventricular leukomalacia and cerebral palsy is uncertain because of the variability of study designs and definitions of chorioamnionitis. Im... | 24,524,448 | D001930:Brain Injuries; D002547:Cerebral Palsy; D002821:Chorioamnionitis; D016207:Cytokines; D005260:Female; D005315:Fetal Diseases; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D018836:Inflammation Mediators; D007969:Leukomalacia, Periventricular; D009413:Nerve Fibers, Myelinated; D011247:Pregna... | Clinics in perinatology | 2,014 | D016207:Cytokines; D018836:Inflammation Mediators | |
Dendrimers as nonviral vectors in dendritic cell-based immunotherapies against human immunodeficiency virus: steps toward their clinical evaluation. | Although the antiretroviral therapy has led to a long-term control of HIV-1, it does not cure the disease. Therefore, several strategies are being explored to develop an effective HIV vaccine, such as the use of dendritic cells (DCs). DC-based immunotherapies bear different limitations, but one of the most critical poi... | 10.2217/nnm.14.172 | 25,529,571 | D016915:AIDS Vaccines; D000938:Antigen-Presenting Cells; D050091:Dendrimers; D003713:Dendritic Cells; D005822:Genetic Vectors; D015658:HIV Infections; D015497:HIV-1; D006801:Humans; D007167:Immunotherapy | Nanomedicine (London, England) | 2,014 | D016915:AIDS Vaccines; D050091:Dendrimers |
Structural basis for chitin acquisition by marine Vibrio species. | Chitin, an insoluble polymer of N-acetylglucosamine, is one of the most abundant biopolymers on Earth. By degrading chitin, chitinolytic bacteria such as Vibrio harveyi are critical for chitin recycling and maintenance of carbon and nitrogen cycles in the world's oceans. A decisive step in chitin degradation is the upt... | 10.1038/s41467-017-02523-y | 29,335,469 | D000117:Acetylglucosamine; D001425:Bacterial Outer Membrane Proteins; D002244:Carbon; D057486:Carbon Cycle; D002686:Chitin; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D009584:Nitrogen; D058458:Nitrogen Cycle; D009792:Oceans and Seas; D009844:Oligosaccharides; D018272:Porins; D011487:Protein Conformation... | Nature communications | 2,018 | D001425:Bacterial Outer Membrane Proteins; D009844:Oligosaccharides; D018272:Porins; D002686:Chitin; D002244:Carbon; D009584:Nitrogen; D000117:Acetylglucosamine |
Acceleration of bone regeneration of horizontal bone defect in rats using collagen-binding basic fibroblast growth factor combined with collagen scaffolds. | BACKGROUND
Basic fibroblast growth factor (bFGF) has been applied for periodontal regeneration. However, the application depends on bone defect morphology because bFGF diffuses rapidly from defect sites. In a previous study, collagen-binding bFGF (CB-bFGF) has been shown to enhance bone formation by collagen-anchoring ... | 10.1002/JPER.18-0674 | 30,889,294 | D000054:Acceleration; D000818:Animals; D001861:Bone Regeneration; D003094:Collagen; D016222:Fibroblast Growth Factor 2; D051381:Rats; D055114:X-Ray Microtomography | Journal of periodontology | 2,019 | D016222:Fibroblast Growth Factor 2; D003094:Collagen |
A History of the Lobes of the Brain. | The division of the cerebrum into 5 lobes is widely accepted in the scientific community. Despite this, a history of the lobes of the brain has not been discussed in the literature. Therefore, this article recounts this history with emphasis on the contributions of Thomas Willis (1664), Felix Vicq d'Azyr (1796), Johann... | 10.1016/j.wneu.2019.10.155 | 31,682,988 | D001921:Brain; D049668:History, 15th Century; D049669:History, 16th Century; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049690:History, Ancient; D049691:History, Medieval; D006801:Humans; D009445:Neuroanatomy | World neurosurgery | 2,020 | |
The impact of social ties and SARS memory on the public awareness of 2019 novel coronavirus (SARS-CoV-2) outbreak. | This study examines publicly available online search data in China to investigate the spread of public awareness of the 2019 novel coronavirus (SARS-CoV-2) outbreak. We found that cities that had previously suffered from SARS (in 2003-04) and have greater migration ties to Wuhan had earlier, stronger and more durable p... | 10.1038/s41598-020-75318-9 | 33,106,506 | D001364:Awareness; D000073640:Betacoronavirus; D057218:Blogging; D000086382:COVID-19; D002681:China; D018352:Coronavirus Infections; D004196:Disease Outbreaks; D006801:Humans; D007398:Interpersonal Relations; D008568:Memory; D058873:Pandemics; D011024:Pneumonia, Viral; D000086402:SARS-CoV-2; D061108:Social Media | Scientific reports | 2,020 | |
Transformation of iopamidol and atrazine by peroxymonosulfate under catalysis of a composite iron corrosion product (Fe/Fe3O4): Electron transfer, active species and reaction pathways. | Cast iron pipes are commonly applied in drinking water distribution systems (DWDSs); peroxymonosulfate (PMS) is a promising alternative for drinking water disinfection; organic micropollutants is still present in drinking water after waterworks' treatment. However, iron corrosion products may affect the reactions betwe... | 10.1016/j.jhazmat.2020.123553 | 32,755,737 | Journal of hazardous materials | 2,021 | ||
Validation of a Sensor-Based Gait Analysis System with a Gold-Standard Motion Capture System in Patients with Parkinson's Disease. | Digital technologies provide the opportunity to analyze gait patterns in patients with Parkinson's Disease using wearable sensors in clinical settings and a home environment. Confirming the technical validity of inertial sensors with a 3D motion capture system is a necessary step for the clinical application of sensor-... | 10.3390/s21227680 | 34,833,755 | D005684:Gait; D000077107:Gait Analysis; D020233:Gait Disorders, Neurologic; D006801:Humans; D010300:Parkinson Disease; D015203:Reproducibility of Results; D016138:Walking | Sensors (Basel, Switzerland) | 2,021 | |
Familial hepatocellular carcinoma and hepatitis B antigenemia in a New Zealand Chinese family. | Primary hepatocellular carcinoma (HCC), is reported in three and probably a fourth member of a New Zealand Chinese family, with a high carrier rate of HBsAg. Hepatitis B virus (HBV) markers and HLA tissue types were analysed in the three generations of the expanded family of 35. Twenty-one of the three generations were... | 10.1111/j.1445-5994.1983.tb04650.x | 6,314,959 | D006528:Carcinoma, Hepatocellular; D002353:Carrier State; D002681:China; D005006:Ethnicity; D005260:Female; D006680:HLA Antigens; D006509:Hepatitis B; D006511:Hepatitis B Antigens; D006514:Hepatitis B Surface Antigens; D006801:Humans; D008113:Liver Neoplasms; D008297:Male; D008875:Middle Aged; D009520:New Zealand | Australian and New Zealand journal of medicine | 1,983 | D006680:HLA Antigens; D006511:Hepatitis B Antigens; D006514:Hepatitis B Surface Antigens |
Association of programmed cell death-1 (PDCD-1) gene polymorphisms with rheumatoid arthritis in Iranian patients. | OBJECTIVES
Programmed cell death 1 (PDCD-1, also named PD-1, CD279, and SLEB2), a negative T cell regulator to maintain peripheral tolerance, induces negative signals to T cells during interaction with its ligands and is therefore a candidate gene in the development of autoimmune diseases such as rheumatoid arthritis (... | 21,961,966 | D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism,... | Clinical and experimental rheumatology | 2,011 | C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor | |
Investigations into the cellular contribution to host tissue proteases and inhibitors in gingival crevicular fluid. | Gingival crevicular fluid (GCF) was collected from chronic periodontitis patients using plastic micropipettes and coverslip smears stained with antibodies for leukocyte markers and Toluidine Blue for mast cells. The smears consisted of 70-80% granulocytes, 10-20% monocytes/macrophages, 5% mast cells and 5% T lymphocyte... | 10.1111/j.1600-051x.1997.tb00207.x | 9,205,922 | D015081:2-Naphthylamine; D000328:Adult; D000469:Alkaline Phosphatase; D000906:Antibodies; D002401:Cathepsin B; D002908:Chronic Disease; D004396:Coloring Agents; D003979:Diazonium Compounds; D018819:Dipeptidyl Peptidase 4; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D018450:Disease Progression; D010450:End... | Journal of clinical periodontology | 1,997 | D000906:Antibodies; D004396:Coloring Agents; D003979:Diazonium Compounds; D011480:Protease Inhibitors; D012394:Rosaniline Dyes; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D014048:Tolonium Chloride; C020747:Fast Blue B; D015081:2-Naphthylamine; D000469:Alkaline Phosphatase; D010450:Endopeptidases; D00415... |
Neurokinin-1 receptor antagonists block acute cocaine-induced horizontal locomotion. | Systemic exposure to neurokinin-1 receptor antagonists CP099994 or LY306740 prior to cocaine administration (10 mg/kg i.p.) blocks acute, cocaine-induced horizontal locomotion. CP099994 (30 mg/kg) was delivered i.p. 30 minutes before cocaine exposure, and LY306740 (5 mg/kg) was delivered continuously by osmotic minipum... | 10.1111/j.1749-6632.2001.tb03562.x | 11,458,534 | D000081:Acetamides; D000818:Animals; D003042:Cocaine; D003342:Corpus Striatum; D018765:Dopamine Uptake Inhibitors; D008124:Locomotion; D008297:Male; D064729:Neurokinin-1 Receptor Antagonists; D051381:Rats; D017207:Rats, Sprague-Dawley; D018040:Receptors, Neurokinin-1; D013373:Substance P | Annals of the New York Academy of Sciences | 2,001 | D000081:Acetamides; D018765:Dopamine Uptake Inhibitors; C102280:LY 306740; D064729:Neurokinin-1 Receptor Antagonists; D018040:Receptors, Neurokinin-1; D013373:Substance P; D003042:Cocaine |
Active site analysis of yeast flavohemoglobin based on its structure with a small ligand or econazole. | UNLABELLED
Flavohemoglobins (flavoHbs) serve various microorganisms as the major protective enzymes against NO˙-mediated toxicity. FlavoHbs dominantly function as an NO˙ dioxygenase (O2+ NO→ NO3 -), the required electron being shuttled from NAD(P)H via FAD to the heme iron. The X-ray structures of the flavoHb from Sacc... | 10.1111/febs.12043 | 23,095,020 | D001665:Binding Sites; D002384:Catalysis; D020134:Catalytic Domain; D049308:Dioxygenases; D004464:Econazole; D006420:Hemeproteins; D008024:Ligands; D008958:Models, Molecular; D011487:Protein Conformation; D029701:Saccharomyces cerevisiae Proteins | The FEBS journal | 2,012 | D006420:Hemeproteins; D008024:Ligands; D029701:Saccharomyces cerevisiae Proteins; D004464:Econazole; D049308:Dioxygenases; C101796:YHB1 protein, S cerevisiae |
Association between kidney disease measures and intracranial atherosclerosis: The ARIC study. | OBJECTIVE
To test the association between reduced kidney function (assessed by estimated glomerular filtration rate [eGFR] and cystatin C [CysC]) and kidney damage (assessed by urinary albumin-to-creatinine ratio [ACR]) and intracranial atherosclerotic disease (ICAD) by high-resolution vessel wall MRI (VWMRI) in the At... | 10.1212/WNL.0000000000009311 | 32,303,651 | D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D057187:Independent Living; D002537:Intracranial Arteriosclerosis; D007677:Kidney Function Tests; D008297:Male; D000073216:Mental Status and Dementia Test... | Neurology | 2,020 | |
In Vitro Activity of Ceftazidime-Avibactam Alone and in Combination with Amikacin Against Colistin-Resistant Gram-Negative Pathogens. | Colistin became the critical treatment option for multidrug-resistant Gram-negative bacteria (GNB); however, resistance to colistin is increasingly being reported among clinical isolates. New therapy strategies should be considered nowadays. The aim of this study was to investigate the in vitro activity of a novel β-la... | 10.1089/mdr.2019.0463 | 32,721,272 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000583:Amikacin; D000900:Anti-Bacterial Agents; D053961:Azabicyclo Compounds; D001426:Bacterial Proteins; D002442:Ceftazidime; D003091:Colistin; D004338:Drug Combinations; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D005798:Genes, Bacterial; D00... | Microbial drug resistance (Larchmont, N.Y.) | 2,021 | D000900:Anti-Bacterial Agents; D053961:Azabicyclo Compounds; D001426:Bacterial Proteins; D004338:Drug Combinations; C000595613:avibactam, ceftazidime drug combination; D000583:Amikacin; D002442:Ceftazidime; D001618:beta-Lactamases; C063912:carbapenemase; D003091:Colistin |
TopoWellPlate: A Well-Plate-Based Screening Platform to Study Cell-Surface Topography Interactions. | The field of biomaterial engineering is increasingly using high-throughput approaches to investigate cell-material interactions. Because most material libraries are prepared as chips, immunofluorescence-based read-outs are used to uniquely image individual materials. This paper proposes to produce libraries of material... | 10.1002/adbi.201700002 | 32,646,161 | Advanced biosystems | 2,017 | ||
Radiotherapy-Associated Pelvic Insufficiency Fracture Treated by Romosozumab: Course of CT Attenuations at L1 and L5. | Pelvic radiation therapy (RT) is a risk factor for pelvic insufficiency fracture, which may be accompanied by significant pain, decreased self-sufficiency, and impaired mobility. Assessment of bone density with "opportunistic" computed tomography (CT) attenuation of the L1 vertebral body can be used as a surrogate for ... | 10.1210/jendso/bvac152 | 36,330,291 | Journal of the Endocrine Society | 2,022 | ||
Management of pseudophakic cystoid macular edema. | Pseudophakic cystoid macular edema (PCME) is a common complication following cataract surgery. Acute PCME may resolve spontaneously, but some patients will develop chronic macular edema that affects vision and is difficult to treat. This disease was described more than 50 years ago, and there are multiple options for c... | 25,438,734 | D020533:Angiogenesis Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002387:Cataract Extraction; D004359:Drug Therapy, Combination; D005938:Glucocorticoids; D006801:Humans; D008269:Macular Edema; D019591:Pseudophakia; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A; D014821:Vitrectomy | Survey of ophthalmology | 2,015 | D020533:Angiogenesis Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D042461:Vascular Endothelial Growth Factor A | |
[Otologic signs and early diagnosis of Turner syndrome. Reevaluation of 30 cases]. | In most occasions the Turner's syndrome is diagnosed on the basis of severe growth retardation. But the possibility of an effective treatment of short stature requires earlier a diagnosis. Among the other signs, the importance of ORL signs is underestimated. A group of 30 patients has been analysed to determine their p... | 3,221,207 | D000293:Adolescent; D001299:Audiometry; D002648:Child; D002675:Child, Preschool; D004423:Ear; D004431:Ear, External; D004432:Ear, Middle; D005260:Female; D006801:Humans; D007223:Infant; D008875:Middle Aged; D010033:Otitis Media; D014424:Turner Syndrome | Journal de genetique humaine | 1,988 | ||
Transplanting the pathway engineering toolbox to methanogens. | Biological methanogenesis evolved early in Earth's history and was likely already a major process by 3.5 Ga. Modern methanogenesis is now a key process in virtually all anaerobic microbial communities, such as marine and lake sediments, wetland and rice soils, and human and cattle digestive tracts. Owing to their long ... | 10.1016/j.copbio.2019.02.009 | 30,875,664 | D000818:Animals; D052837:Chemoautotrophic Growth; D017753:Ecosystem; D006801:Humans; D008697:Methane; D012987:Soil | Current opinion in biotechnology | 2,019 | D012987:Soil; D008697:Methane |
Antiviral efficacy of orally delivered neoagarohexaose, a nonconventional TLR4 agonist, against norovirus infection in mice. | The neoagarohexaose (NA6) is an oligosaccharide that is derived from agarose, the major component of red algae cell walls, by enzymatic hydrolysis. Here we show that NA6 is a noncanonical Toll-like receptor 4 (TLR4) agonist with antiviral activity against norovirus. Its TLR4 activation was dependent on myeloid differen... | 10.1016/j.biomaterials.2020.120391 | 32,977,259 | D000818:Animals; D000998:Antiviral Agents; D017250:Caliciviridae Infections; D051379:Mice; D018345:Mice, Knockout; D029322:Norovirus; D051197:Toll-Like Receptor 4; D014779:Virus Replication | Biomaterials | 2,020 | D000998:Antiviral Agents; C493487:Tlr4 protein, mouse; D051197:Toll-Like Receptor 4 |
RNA editing in trypanosomes. | The nucleotide sequence of mitochondrial pre-mRNAs in trypanosomes is posttranscriptionally edited by the insertion and deletion of uridylate (U) residues. In some RNAs editing is limited to small sections but in African trypanosomes, such as Trypanosoma brucei, 9 of the 18 known mitochondrial mRNAs are created by mass... | 10.1111/j.1432-1033.1994.tb18710.x | 7,513,284 | D000818:Animals; D001483:Base Sequence; D008928:Mitochondria; D008969:Molecular Sequence Data; D012313:RNA; D017393:RNA Editing; D000077278:RNA, Mitochondrial; D014345:Trypanosoma | European journal of biochemistry | 1,994 | D000077278:RNA, Mitochondrial; D012313:RNA |
Microbial Population of the Digestive Tract of Click Beetle Larvae (Elateridae, Coleoptera). | The composition and functional structure of the intestinal microflora of three wireworm species (Agriotes obscurus (L.), Selatosomus aeneus (L.), and Ampedus pomorum (Herbst)) with different dietary regimes were studied. The total abundance of the microorganisms was evaluated by fluorescent microscopy, the group compos... | 30,226,940 | D000150:Acinetobacter; D000818:Animals; D001517:Coleoptera; D004885:Erwinia; D005658:Fungi; D000069196:Gastrointestinal Microbiome; D007814:Larva; D014737:Vibrionaceae | Izvestiia Akademii nauk. Seriia biologicheskaia | 2,016 | ||
[Therapy of acute salicylate poisoning]. | Poisoning with salicylic acid and its derivatives is a quite common event, leading to possibly life-threatening complications. A case of fatal intoxication of a sixty-year old patient with acetylsalicylic acid is described and the therapeutic options are discussed. In acute poisoning it is mandatory to initiate simple ... | 8,211,029 | D001241:Aspirin; D002606:Charcoal; D003128:Coma; D017809:Fatal Outcome; D005260:Female; D005334:Fever; D005751:Gastric Lavage; D005998:Glycine; D006464:Hemoperfusion; D006801:Humans; D008875:Middle Aged; D011041:Poisoning; D006435:Renal Dialysis; D012459:Salicylates; D017693:Sodium Bicarbonate | Schweizerische medizinische Wochenschrift | 1,993 | D012459:Salicylates; D002606:Charcoal; D017693:Sodium Bicarbonate; D001241:Aspirin; D005998:Glycine | |
In vivo biodistribution of antihyperglycemic biopolymer-based nanoparticles for the treatment of type 1 and type 2 diabetes. | This study aimed to assess the biodistribution of antihyperglycemic insulin-loaded alginate/dextran sulfate-based nanoparticles dual coated with chitosan and technetium-99m-albumin (99mTc-BSA) after oral administration. The oral administration of 50IU/kg insulin-loaded nanoparticles to type 1 diabetic rats showed prolo... | 10.1016/j.ejpb.2016.11.037 | 28,007,370 | D000818:Animals; D001704:Biopolymers; D003921:Diabetes Mellitus, Experimental; D003922:Diabetes Mellitus, Type 1; D003924:Diabetes Mellitus, Type 2; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents; D007328:Insulin; D008297:Male; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D051381:Rats; D0... | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V | 2,017 | D001704:Biopolymers; D007004:Hypoglycemic Agents; D007328:Insulin; D013311:Streptozocin |
ChGn-2 Plays a Cardioprotective Role in Heart Failure Caused by Acute Pressure Overload. | Background Cardiac extracellular matrix is critically involved in cardiac homeostasis, and accumulation of chondroitin sulfate glycosaminoglycans (CS-GAGs) was previously shown to exacerbate heart failure by augmenting inflammation and fibrosis at the chronic phase. However, the mechanism by which CS-GAGs affect cardia... | 10.1161/JAHA.121.023401 | 35,322,673 | D000818:Animals; D005109:Extracellular Matrix; D005347:Fibroblasts; D005355:Fibrosis; D006025:Glycosaminoglycans; D006333:Heart Failure; D051379:Mice | Journal of the American Heart Association | 2,022 | D006025:Glycosaminoglycans |
Motor-Independent Cognitive Testing in Motor Degenerative Diseases. | Cognitive function is tested through speech- or writing-based neuropsychological instruments. The application and validity of those tests is impeded for patients with diseases that affect speech and hand motor skills. We therefore developed a "motor-free" gaze-controlled version of the Trail Making Test (TMT), includin... | 10.3390/jcm11030814 | 35,160,265 | Journal of clinical medicine | 2,022 | ||
A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females. | OBJECTIVE
The present study aimed to investigate possible association of the apolipoprotein E (APOE) gene polymorphisms with age at natural menopause (ANM) in Caucasian females.
DESIGN
Four SNPs (including two replacements, SNP3 Cys112Arg and SNP4 Arg158Cys) were genotyped in 253 randomly selected unrelated Caucasian... | 10.1016/j.maturitas.2008.10.011 | 19,058,936 | D000328:Adult; D000375:Aging; D000428:Alcohol Drinking; D001057:Apolipoproteins E; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044465:White People | Maturitas | 2,009 | D001057:Apolipoproteins E |
Expression of cyclin-dependent kinase inhibitor p27/Kip1 and AP-1 coactivator p38/Jab1 correlates with differentiation of embryonal rhabdomyosarcoma. | Cyclin-dependent kinase (CDK) inhibitor p27/Kip1 (p27) is a diagnostic and prognostic marker of various malignancies. Low expression of p27 reflects poor differentiation and poor prognosis, and an inverse correlation between the expression of p27 and degree of tumor malignancy has been reported. Because p27 mutation is... | 10.1111/j.1349-7006.2002.tb02476.x | 12,359,053 | D000075686:COP9 Signalosome Complex; D018797:Cell Cycle Proteins; D002454:Cell Differentiation; D002648:Child; D002675:Child, Preschool; D050760:Cyclin-Dependent Kinase Inhibitor p27; D004268:DNA-Binding Proteins; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D047908:Intracellular Signal... | Japanese journal of cancer research : Gann | 2,002 | D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D010447:Peptide Hydrolases; C501488:COPS5 protein, human; D000075686:COP9 Signalosome Complex |
Telomeres: the long and short of developing non-Hodgkin lymphoma. | Chromosomal integrity is vital to the life span of the dividing cell. Telomeres are tandem sequences at chromosome ends that provide protection for the genetic coding material. Erosion of those ends leads to cell death. Does stabilization promote cancer? | 10.1158/1078-0432.CCR-09-2233 | 19,934,285 | D016923:Cell Death; D002875:Chromosomes; D015331:Cohort Studies; D006801:Humans; D008214:Lymphocytes; D008228:Lymphoma, Non-Hodgkin; D008297:Male; D012107:Research Design; D012306:Risk; D012907:Smoking; D016615:Telomere | Clinical cancer research : an official journal of the American Association for Cancer Research | 2,009 | |
Health-related quality of life of Canadian children and youth prenatally exposed to alcohol. | BACKGROUND
In Canada, the incidence of Fetal Alcohol Spectrum Disorder (FASD) has been estimated to be 1 in 100 live births. Caused by prenatal exposure to alcohol, FASD is the leading cause of neuro-developmental disabilities among Canadian children, and youth.
OBJECTIVE
To measure the health-related quality of life... | 10.1186/1477-7525-4-81 | 17,040,571 | D000293:Adolescent; D000328:Adult; D001007:Anxiety; D002170:Canada; D002648:Child; D002653:Child Behavior Disorders; D016001:Confidence Intervals; D003863:Depression; D002658:Developmental Disabilities; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders; D006801:Humans; D008297:Male; D010465:Perception; D011247:P... | Health and quality of life outcomes | 2,006 | |
Restoration of Foxp3+ Regulatory T-cell Subsets and Foxp3- Type 1 Regulatory-like T Cells in Inflammatory Bowel Diseases During Anti-tumor Necrosis Factor Therapy. | BACKGROUND
A defect in regulatory T cells (Tregs) may be involved in the pathogenesis of inflammatory bowel diseases (IBD). Several subsets of human Foxp3+ Tregs (activated and resting Tregs) have now been identified, as well as an IL-10 and IFN-γ double producing Foxp3 type 1 regulatory-like T cell (Tr1L). We have qua... | 10.1097/MIB.0000000000000509 | 26,308,438 | D000328:Adult; D000368:Aged; D015496:CD4-Positive T-Lymphocytes; D016022:Case-Control Studies; D005260:Female; D005434:Flow Cytometry; D051858:Forkhead Transcription Factors; D005765:Gastrointestinal Agents; D064368:Healthy Volunteers; D006801:Humans; D015212:Inflammatory Bowel Diseases; D000069285:Infliximab; D017493:... | Inflammatory bowel diseases | 2,015 | C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D005765:Gastrointestinal Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab; D017493:Leukocyte Common Antigens |
Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. | Exposure to cigarette smoke (CS) is a known risk factor in the pathogenesis of smoking-caused diseases, such as chronic obstructive pulmonary diseases (COPD) and lung cancer. To assess the effects of CS on the function and phenotype of airway epithelial cells, we developed a novel repeated treatment protocol and compre... | 10.1007/s00204-021-03008-0 | 33,660,061 | D000818:Animals; D001980:Bronchi; D002478:Cells, Cultured; D016207:Cytokines; D004847:Epithelial Cells; D020869:Gene Expression Profiling; D006801:Humans; D008168:Lung; D008175:Lung Neoplasms; D018384:Oxidative Stress; D029424:Pulmonary Disease, Chronic Obstructive; D012906:Smoke; D012907:Smoking; D014026:Nicotiana; D0... | Archives of toxicology | 2,021 | D016207:Cytokines; D012906:Smoke; D014028:Tobacco Smoke Pollution |
Gender differences in pharmacological and clinical associates of kidney disease. A hospital-based study. | OBJECTIVE
The objective of this study was to identify the pharmacological and clinical associates of kidney disease among males and females.
SUBJECTS AND METHODS
This is a cross-sectional retrospective study. All patients admitted to the Department of Internal Medicine at Al-Watani Hospital were included in the study... | 10.1159/000112962 | 18,287,792 | D000368:Aged; D002318:Cardiovascular Diseases; D016022:Case-Control Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D048909:Diabetes Complications; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases; D016015... | Medical principles and practice : international journal of the Kuwait University, Health Science Centre | 2,008 | |
Self-categorization with a novel mixed-race group moderates automatic social and racial biases. | People perceive and evaluate others according to social categories. Yet social perception is complicated by the fact that people have multiple social identities, and self-categorization with these identities shifts from one situation to another. Two experiments examined whether self-categorization with a novel mixed-ra... | 10.1177/0146167208327743 | 19,098,257 | D001741:Black or African American; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D008960:Models, Psychological; D011287:Prejudice; D044469:Racial Groups; D012649:Self Concept; D012919:Social Behavior; D012933:Social Identification; D012938:Social Perception; D013240:Stereotyping; D04446... | Personality & social psychology bulletin | 2,009 | |
Bioconjugated quantum dots for in vivo molecular and cellular imaging. | Semiconductor quantum dots (QDs) are tiny light-emitting particles on the nanometer scale, and are emerging as a new class of fluorescent labels for biology and medicine. In comparison with organic dyes and fluorescent proteins, they have unique optical and electronic properties, with size-tunable light emission, super... | 10.1016/j.addr.2008.03.015 | 18,495,291 | D000818:Animals; D001672:Biocompatible Materials; D003952:Diagnostic Imaging; D016503:Drug Delivery Systems; D006801:Humans; D036103:Nanotechnology; D009369:Neoplasms; D045663:Quantum Dots; D014018:Tissue Distribution | Advanced drug delivery reviews | 2,008 | D001672:Biocompatible Materials |
[The changes of HIF-1α and AMPKα2 expression levels during skeletal muscle blunt injury recovery]. | OBJECTIVE
To explore the possible biological mechanisms of skeletal muscle injury recovery by observing the changes of AMP-activated protein kinase α2 (AMPKα2) and hypoxia inducible factor-1α (HIF-1α) expression levels of rats in the skeletal muscle blunt injury recovery process.
METHODS
Six of the 48 male Wistar rat... | 10.13459/j.cnki.cjap.2016.03.018 | 29,931,888 | D055372:AMP-Activated Protein Kinases; D000818:Animals; D006614:Hindlimb; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008297:Male; D018482:Muscle, Skeletal; D051381:Rats; D017208:Rats, Wistar; D014949:Wounds, Nonpenetrating | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology | 2,016 | C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C543928:Prkaa2 protein, rat; D055372:AMP-Activated Protein Kinases |
Amplification and functional characterization of MUC1 promoter and gene-virotherapy via a targeting adenoviral vector expressing hSSTR2 gene in MUC1-positive Panc-1 pancreatic cancer cells in vitro. | Mucin1 (MUC1) promoter has been cloned from the 5' flanking region of the MUC1 gene in breast carcinoma, functionally characterized and applied in gene therapy of breast and esophageal carcinoma. In the present study, we amplified a 786 base pair (bp) MUC1 promoter by two-step nest PCR, and identified the activity and ... | 15,754,023 | D000256:Adenoviridae; D000941:Antigens; D000951:Antigens, Neoplasm; D001483:Base Sequence; D003587:Cytomegalovirus; D015316:Genetic Therapy; D005822:Genetic Vectors; D006023:Glycoproteins; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D018396:Mucin-1; D009077:Mucins; D010190:Pancreatic Neoplasms;... | International journal of molecular medicine | 2,005 | D000941:Antigens; D000951:Antigens, Neoplasm; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D017481:Receptors, Somatostatin; C093733:somatostatin receptor 2 | |
Implementation and validation of three automated methods for measuring ultrasound maximum depth of penetration: application to ultrasound quality control. | Systematic measurements of maximum depth of penetration (DOP) of ultrasound (US) scanners are essential for quality control (QC). Conventionally, DOP measurements are performed visually and as such they could be affected by various external factors, scanner control settings, and operator related errors. Automated metho... | 10.1118/1.1951095 | 16,193,792 | D000465:Algorithms; D001185:Artificial Intelligence; D007089:Image Enhancement; D007090:Image Interpretation, Computer-Assisted; D008954:Models, Biological; D019047:Phantoms, Imaging; D011785:Quality Assurance, Health Care; D011786:Quality Control; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity... | Medical physics | 2,005 | |
[Care of patients with type 2 diabetes mellitus in primary care]. | Over the past 20 years, delivery ofdiabetes care in the Netherlands has shifted from secondary to primary care. Currently over 75% of all patients with type 2 diabetes mellitus are being treated by a diabetes team in general practice. Since 2000 both national and international publications have been describing the orga... | 19,055,137 | D003695:Delivery of Health Care; D003924:Diabetes Mellitus, Type 2; D005006:Ethnicity; D006801:Humans; D009426:Netherlands; D010818:Practice Patterns, Physicians'; D011320:Primary Health Care; D011787:Quality of Health Care; D012959:Socioeconomic Factors | Nederlands tijdschrift voor geneeskunde | 2,008 | ||
Angiotensinogen is an acute-phase protein in man. | Accumulating information concerning the structure of angiotensinogen suggests a resemblance of this component of the renin-angiotensin system to the acute-phase protein alpha 1-antitrypsin. Compared to a group of age- and sex-matched controls without signs of infection, markedly elevated levels of angiotensinogen (incr... | 3,495,031 | D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000808:Angiotensinogen; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D000515:alpha 1-Antitrypsin | Scandinavian journal of clinical and laboratory investigation | 1,987 | D000515:alpha 1-Antitrypsin; D000808:Angiotensinogen | |
An inexpensive, MRI compatible device to measure tidal volume from chest-wall circumference. | Mouthpieces and masks change breathing, and distract the subject. Accepted non-invasive methods avoid this problem, inductive plethysmographs and respiratory magnetometers, but are expensive and unusable in magnetic resonance imaging (MRI) scanners. Because changes in ventilation affect arterial gases, and thus cerebra... | 10.1088/0967-3334/28/2/004 | 17,237,587 | D000328:Adult; D002138:Calibration; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015203:Reproducibility of Results; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics; D012815:Signal Processing, Computer-Assisted; D012984:Software; D035441:Thoracic Wall; D013990:Tidal Volume; D01416... | Physiological measurement | 2,007 | |
Low glycemic load experimental diet more satiating than high glycemic load diet. | Effective strategies for reducing food intake are needed to reduce risk of obesity-related cancers. We investigated the effect of low and high glycemic load (GL) diets on satiety and whether satiety varied by body mass index (BMI), gender, and serum leptin. Eighty normal weight (BMI = 18.5-24.9 kg/m²) and overweight/ o... | 10.1080/01635581.2012.676143 | 22,564,018 | D050154:Adiposity; D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D018592:Cross-Over Studies; D004038:Diet, Reducing; D004043:Dietary Fiber; D005260:Female; D005518:Food Preferences; D038321:Glycemic Index; D006801:Humans; D020738:Leptin; D008297:Male; D008875:Middle Aged; D009765:Obesity; D050177:Overweig... | Nutrition and cancer | 2,012 | D004043:Dietary Fiber; D020738:Leptin |
Assessment of acculturation in minority health research. | Acculturation represents an important construct in the context of health disparities. Although several studies have reported relationships between various aspects of acculturation and health in minority populations, crucial inconsistencies remain. One likely reason for these inconsistencies may relate to limitations in... | 10.1016/j.socscimed.2017.01.029 | 28,135,691 | D000069:Acculturation; D054521:Cultural Competency; D006801:Humans; D008913:Minority Groups; D063505:Racism; D012107:Research Design; D011795:Surveys and Questionnaires | Social science & medicine (1982) | 2,017 | |
Identification of Proteins Involved in Carbohydrate Metabolism and Energy Metabolism Pathways and Their Regulation of Cytoplasmic Male Sterility in Wheat. | Cytoplasmic male sterility (CMS) where no functional pollen is produced has important roles in wheat breeding. The anther is a unique organ for male gametogenesis and its abnormal development can cause male sterility. However, the mechanisms and regulatory networks related to plant male sterility are poorly understood.... | 10.3390/ijms19020324 | 29,360,773 | D000255:Adenosine Triphosphate; D050260:Carbohydrate Metabolism; D019295:Computational Biology; D003593:Cytoplasm; D004734:Energy Metabolism; D018506:Gene Expression Regulation, Plant; D063990:Gene Ontology; D053858:Metabolic Networks and Pathways; D010641:Phenotype; D051479:Plant Infertility; D010940:Plant Proteins; D... | International journal of molecular sciences | 2,018 | D010940:Plant Proteins; D017382:Reactive Oxygen Species; D000073893:Sugars; D000255:Adenosine Triphosphate |
FoxP1 marks medium spiny neurons from precursors to maturity and is required for their differentiation. | Identifying the steps involved in striatal development is important both for understanding the striatum in health and disease, and for generating protocols to differentiate striatal neurons for regenerative medicine. The most prominent neuronal subtype in the adult striatum is the medium spiny projection neuron (MSN), ... | 27,154,297 | D000818:Animals; D000831:Animals, Newborn; D002352:Carrier Proteins; D002454:Cell Differentiation; D002478:Cells, Cultured; D003342:Corpus Striatum; D051937:Dopamine and cAMP-Regulated Phosphoprotein 32; D004622:Embryo, Mammalian; D004706:Endodeoxyribonucleases; D005333:Fetus; D051858:Forkhead Transcription Factors; D0... | Experimental neurology | 2,016 | D002352:Carrier Proteins; D051937:Dopamine and cAMP-Regulated Phosphoprotein 32; C486626:FOXP1 protein, human; D051858:Forkhead Transcription Factors; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; D004706:Endodeoxyribonucleases; C410741:RBBP8 protein, human | |
Enhancement of Oral Bioavailability of Ibandronate Through Gastroretentive Raft Forming Drug Delivery System: In Vitro and In Vivo Evaluation. | BACKGROUND
Bisphosphonates have very low bioavailability and cause irritation of the esophagus and stomach. This study was planned to improve the oral bioavailability of ibandronate through the formation of a raft in the stomach. Bisphosphonate-induced irritation of the esophagus and stomach is prevented by the formati... | 10.2147/IJN.S255278 | 32,764,922 | D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D018938:Caco-2 Cells; D004337:Drug Carriers; D005753:Gastric Mucosa; D006801:Humans; D000077557:Ibandronic Acid; D008297:Male; D010368:Pectins; D051381:Rats | International journal of nanomedicine | 2,020 | D004337:Drug Carriers; C586814:citrus pectin; D010368:Pectins; D000077557:Ibandronic Acid |
Material remodeling and unconventional gaits facilitate locomotion of a robophysical rover over granular terrain. | Autonomous robots and vehicles must occasionally recover from locomotion failure in loosely consolidated granular terrain. Recent mobility challenges led NASA Johnson Space Center to develop a prototype robotic lunar rover Resource Prospector 15 (RP15) capable of wheeled, legged, and crawling behavior. To systematicall... | 10.1126/scirobotics.aba3499 | 33,022,621 | Science robotics | 2,020 | ||
Inversion of Dispersion: Colloidal Stability of Calixarene-Modified Metal-Organic Framework Nanoparticles in Nonpolar Media. | Making metal-organic frameworks (MOFs) that are stabilized in nonpolar media is not as straightforward as making their inorganic nanoparticle counterparts, since surfactants penetrate through the porous structures or dissolve the secondary building units (SBUs) through ligand-exchange linker modulator mechanisms. Herei... | 10.1021/jacs.9b04198 | 31,184,882 | D047250:Calixarenes; D003102:Colloids; D000073396:Metal-Organic Frameworks; D053758:Nanoparticles; D016062:Porosity; D013499:Surface Properties | Journal of the American Chemical Society | 2,019 | D003102:Colloids; D000073396:Metal-Organic Frameworks; D047250:Calixarenes |
Effects of simulated microgravity on brain plasticity: a startle reflex habituation study. | There is limited but increasing evidence that space environment, namely weightless condition, may affect astronauts' cerebral neurotransmitters and cognitive performance. The present experiment hypothesized that learning and brain plasticity are affected by simulated microgravity condition. To this aim, 22 male subject... | 10.1016/j.physbeh.2011.05.019 | 21,627,974 | D000161:Acoustic Stimulation; D000328:Adult; D000704:Analysis of Variance; D001921:Brain; D004576:Electromyography; D005072:Evoked Potentials, Auditory; D006185:Habituation, Psychophysiologic; D006801:Humans; D008297:Male; D011930:Reaction Time; D013216:Reflex, Startle; D014893:Weightlessness; D018474:Weightlessness Si... | Physiology & behavior | 2,011 | |
Loco-regional perfusions (stop-flow techniques): state of art and future. | The treatment of primary advanced or unresectable recurrent cancers is still one of the main medical challenges. The Stop-flow perfusion has been used as loco-regional chemotherapy based on blood supply blockage of the tumour-bearing area. The aim of the present paper is to report the personal experience in the clinica... | 16,767,917 | D000970:Antineoplastic Agents; D010478:Chemotherapy, Cancer, Regional Perfusion; D006801:Humans; D009364:Neoplasm Recurrence, Local; D009369:Neoplasms; D016019:Survival Analysis; D016896:Treatment Outcome | Journal of experimental & clinical cancer research : CR | 2,003 | D000970:Antineoplastic Agents | |
Selenium protects against the likelihood of fetal neural tube defects partly via the arginine metabolic pathway. | BACKGROUND AND AIMS
Neural tube defects (NTDs) are severe congenital malformations and have a complex etiology. This study aimed to explore the association between selected essential trace elements (ETEs) and metabolic pathway markers in the serum of women and the likelihood of NTDs.
METHODS
The study included 99 mot... | 10.1016/j.clnu.2022.02.006 | 35,263,693 | D001120:Arginine; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D053858:Metabolic Networks and Pathways; D009436:Neural Tube Defects; D012643:Selenium | Clinical nutrition (Edinburgh, Scotland) | 2,022 | D001120:Arginine; D012643:Selenium |
Enantioselective and diastereoselective separation of synthetic pyrethroid insecticides on a novel chiral stationary phase by high-performance liquid chromatography. | A novel chiral packing material for high-performance liquid chromatography (HPLC) was prepared by connecting (R)-1-phenyl-2-(4-methylphenyl) ethylamine (PTE) amide derivative of (S)-isoleucine to aminopropyl silica gel through 2-amino-3,5-dinitro-1-carboxamido-benzene unit. This chiral stationary phase was applied to t... | 10.1002/chir.20423 | 17,508,398 | D002851:Chromatography, High Pressure Liquid; D007306:Insecticides; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011722:Pyrethrins; D013237:Stereoisomerism | Chirality | 2,007 | D007306:Insecticides; D011722:Pyrethrins |
High-Grade Neuroendocrine Carcinoma of the Head and Neck: Human Papillomavirus Status and PD-L1 Expression. | BACKGROUND
Human papillomavirus (HPV)-related head and neck squamous cell carcinoma represents an important subgroup of head and neck cancer, but HPV occurs also in the less common neuroendocrine carcinomas (NEC). The PD-1/PD-L1 pathway appears to be activated in pulmonary NEC and correlates with a higher mutation burd... | 10.1159/000502325 | 31,550,725 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060890:B7-H1 Antigen; D018278:Carcinoma, Neuroendocrine; D002294:Carcinoma, Squamous Cell; D005260:Female; D006258:Head and Neck Neoplasms; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D030361:Papillomavirus Infections; D061027:Pro... | ORL; journal for oto-rhino-laryngology and its related specialties | 2,019 | D060890:B7-H1 Antigen; C423236:CD274 protein, human; D061027:Programmed Cell Death 1 Ligand 2 Protein |
DNA polymerase epsilon: in search of a function. | The current model of eukaryotic DNA replication involves the two DNA polymerases delta and alpha as the leading and lagging strand enzymes, respectively. A DNA polymerase first discovered in yeast has now been found in all eukaryotic cells and is termed DNA polymerase epsilon. In yeast, the gene for DNA polymerase epsi... | 10.1016/0968-0004(92)90499-y | 1,566,327 | D000818:Animals; D004258:DNA Polymerase III; D004260:DNA Repair; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase; D005057:Eukaryotic Cells; D012441:Saccharomyces cerevisiae | Trends in biochemical sciences | 1,992 | D004258:DNA Polymerase III; D004259:DNA-Directed DNA Polymerase |
A New Flavanone from Chromolaena tacotana (Klatt) R. M. King and H. Rob, Promotes Apoptosis in Human Breast Cancer Cells by Downregulating Antiapoptotic Proteins. | Chromolaena tacotana is a source of flavonoids with antiproliferative properties in human breast cancer cells, the most common neoplasm diagnosed in patients worldwide. Until now, the mechanisms of cell death related to the antiproliferative activity of its flavonoids have not been elucidated. In this study, a novel fl... | 10.3390/molecules28010058 | 36,615,253 | D005260:Female; D006801:Humans; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D001943:Breast Neoplasms; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D036604:Chromolaena; D044950:Flavanones; D019253:Proto-Oncogene Proteins c-bcl-2 | Molecules (Basel, Switzerland) | 2,022 | D051017:Apoptosis Regulatory Proteins; D044950:Flavanones; D019253:Proto-Oncogene Proteins c-bcl-2 |
Room to breathe: Using adaptive architecture to examine the relationship between alexithymia and interoception. | OBJECTIVE
Individuals with alexithymia experience difficulties interpreting emotional states in self and others, which has been associated with interoceptive impairment. Current theories are primarily based on subjective and conscious measures of interoceptive sensitivity, such as heartrate detection, but it is unclear... | 10.1016/j.jpsychores.2021.110708 | 34,954,603 | D000342:Affective Symptoms; D004644:Emotions; D006339:Heart Rate; D006801:Humans; D065812:Interoception; D012119:Respiration | Journal of psychosomatic research | 2,022 | |
Toxicological profile of bisphenol F via comprehensive and extensive toxicity evaluations following dermal exposure. | Bisphenol F (BPF) is classified as a harmful substance by the U.S. Environmental Protection Agency. Although previous studies focused on human exposure to BPF via direct consumption or inhalation, few investigators assessed potential toxicological effects following skin contact. The aim of this study was to examine (1)... | 10.1080/15287394.2021.1997843 | 34,763,616 | D000818:Animals; D001559:Benzhydryl Compounds; D005123:Eye; D005260:Female; D006801:Humans; D008297:Male; D010636:Phenols; D011817:Rabbits; D017207:Rats, Sprague-Dawley; D012867:Skin; D012869:Skin Absorption; D023382:Toxicity Tests, Acute | Journal of toxicology and environmental health. Part A | 2,022 | D001559:Benzhydryl Compounds; D010636:Phenols; C000611646:bisphenol F |
Efficacy of denosumab therapy after alendronate treatment for a 66-year-old woman with Camurati-Engelmann disease and osteoporosis: a case report. | Camurati-Engelmann disease (CED) is characterized by hyperostois of multiple long bones. Although several treatments for CED complicated with osteoporosis have been described, it remains controversial whether such therapy is suitable for osteoporotic CED patients. We retrospectively enrolled a 66-year-old female patien... | 10.1080/24725625.2019.1629571 | 33,086,975 | D000368:Aged; D015415:Biomarkers; D050071:Bone Density Conservation Agents; D003966:Camurati-Engelmann Syndrome; D000069448:Denosumab; D005260:Female; D006801:Humans; D010024:Osteoporosis; D016896:Treatment Outcome | Modern rheumatology case reports | 2,020 | D015415:Biomarkers; D050071:Bone Density Conservation Agents; D000069448:Denosumab |
L-carnitine and acetylcarnitine in human sperm with normal and reduced motility. | The differences in the acetylcarnitine/carnitine ratio and the percent of the acetylation in sperm seminal samples have been investigated. The impairment of the enzymatic system controlling the reaction carnitine acetylcarnitine may lead to a defective spermatozoal motility. | 3,630,566 | D000107:Acetylation; D000108:Acetylcarnitine; D002331:Carnitine; D006801:Humans; D008297:Male; D013081:Sperm Motility; D013094:Spermatozoa | Acta Europaea fertilitatis | 1,987 | D000108:Acetylcarnitine; D002331:Carnitine | |
Phenylketonuria: reduced tyrosine brain influx relates to reduced cerebral protein synthesis. | BACKGROUND
In phenylketonuria (PKU), elevated blood phenylalanine (Phe) concentrations are considered to impair transport of large neutral amino acids (LNAAs) from blood to brain. This impairment is believed to underlie cognitive deficits in PKU via different mechanisms, including reduced cerebral protein synthesis. In... | 10.1186/1750-1172-8-133 | 24,007,597 | D000293:Adolescent; D000328:Adult; D001692:Biological Transport; D001921:Brain; D002250:Carbon Radioisotopes; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010661:Phenylketonurias; D014443:Tyrosine; D055815:Young Adult | Orphanet journal of rare diseases | 2,013 | D002250:Carbon Radioisotopes; D014443:Tyrosine |
Effect of Hydrophobic Chain Length on the Antioxidation Properties of Alanyl Tyrosine Dipeptide-type Surfactants. | The antioxidant (AOX) activities of alanyl tyrosine dipeptide-type surfactants with several chain lengths were investigated. The critical micelle concentration decreased exponentially with the carbon number of the hydrophobic chain of the surfactant. The antioxidative property was investigated using the 2,2'-azinobis(3... | 10.5650/jos.ess21250 | 35,110,464 | D000975:Antioxidants; D002244:Carbon; D004151:Dipeptides; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D012996:Solutions; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents; D014443:Tyrosine | Journal of oleo science | 2,022 | D000975:Antioxidants; D004151:Dipeptides; D008823:Micelles; D012996:Solutions; D013501:Surface-Active Agents; D014443:Tyrosine; D002244:Carbon |
Programmatic and ethical challenges in the implementation of treatment-as-prevention in the context of HIV and drug-resistant tuberculosis co-infection in sub-Saharan Africa. | There is limited literature on programmatic challenges in the implementation of a treatment-as-prevention (TasP) strategy among human immunodeficiency virus (HIV) and drug-resistant tuberculosis (DR-TB) co-infected individuals in sub-Saharan Africa (SSA). This paper highlights specific programmatic challenges surroundi... | 10.1080/17441692.2014.988164 | 25,513,964 | Global public health | 2,016 | ||
Protective effects of melatonin receptor agonists on endotoxin-induced uveitis in rats. | Objectives
Melatonin has an important role in regulating a variety of physiological functions of the body. We investigated the protective effects of Agomelatine (AGO) and Ramelteon (RAME) on Endotoxin-Induced Uveitis (EIU) in rats.
Materials and Methods
70 rats were randomly divided into fourteen groups. Healthy grou... | 10.22038/IJBMS.2023.67297.14749 | 37,051,104 | Iranian journal of basic medical sciences | 2,023 | ||
Ciguatera fish poisoning in industrial ship crewmembers: a retrospective study in a seaport general practice in Trinidad and Tobago. | The objective of this study was to outline the epidemiology of Ciguatera fish poisoning as seen in a general practice serving two industrial seaports in Trinidad and Tobago, in order to highlight the potential public health implications. A retrospective study was undertaken of all the cases of Ciguatera fish poisoning ... | 15,622,674 | D000328:Adult; D036841:Ciguatera Poisoning; D004196:Disease Outbreaks; D006801:Humans; D008297:Male; D008875:Middle Aged; D009326:Naval Medicine; D014300:Trinidad and Tobago | The West Indian medical journal | 2,004 | ||
Growth characteristics of nanocrystalline silicon films fabricated by using chlorinated precursors at low temperatures. | We employed plasma enhanced chemical vapor deposition technique to fabricate nanocrystalline Si films at a low temperature of 250 degrees C by using SiCl4 and H2 as source gases. The evolution of microstructure of the films with deposition periods shows that nanocrystalline Si can be directly grown on amorphous substra... | 10.1166/jnn.2010.2894 | 21,137,990 | Journal of nanoscience and nanotechnology | 2,010 | ||
Animal-related facial fractures in South Australia. | BACKGROUND
Animal-related facial fractures can affect livelihoods impacting the hard and soft tissues of the face. Animal husbandry and recreational sports have close relationships with animals, which can lead to injuries equivalent to those of road traffic accidents and assaults. Our aim is to describe epidemiological... | 10.1111/ans.16718 | 33,656,265 | D000063:Accidents, Traffic; D000293:Adolescent; D000818:Animals; D002648:Child; D005147:Facial Bones; D005151:Facial Injuries; D005260:Female; D006736:Horses; D006801:Humans; D012189:Retrospective Studies; D012887:Skull Fractures; D013021:South Australia | ANZ journal of surgery | 2,021 | |
[Priorisation of old critically-ill patients for an ICU admission]. | PRIORISATION OF OLD CRITICALLY-ILL PATIENTS FOR AN ICU ADMISSION There are currently no national or international recommendations for admission decisions to an intensive care unit (icu) for patients over 80 years of age. The decision, whether, or not to admit an elderly patient to intensive care is probably one of the ... | 35,289,518 | D000368:Aged; D000369:Aged, 80 and over; D000086382:COVID-19; D016638:Critical Illness; D006801:Humans; D007362:Intensive Care Units; D010343:Patient Admission; D011788:Quality of Life | La Revue du praticien | 2,022 | ||
Experimental infection with Schistosoma mansoni isolated from the wild rodent Holochilus sciureus shows a low parasite burden but induces high schistosomiasis severity in BALB/c mice. | Wild mammals, especially rodents, can participate in the life cycle of Schistosoma mansoni; however, the impact of these parasite strains on the severity of schistosomiasis remains unclear. The aim of this study was to comparatively evaluate the parasitological and immunopathological alterations induced by an S. manson... | 10.1017/S0031182022000774 | 35,641,335 | D000818:Animals; D006801:Humans; D016753:Interleukin-10; D018664:Interleukin-12; D018793:Interleukin-13; D020381:Interleukin-17; D015848:Interleukin-5; D008099:Liver; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010271:Parasites; D012377:Rodentia; D012550:Schistosoma mansoni; D012552:Schistosomiasis; D0125... | Parasitology | 2,022 | D018793:Interleukin-13; D020381:Interleukin-17; D015848:Interleukin-5; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D018664:Interleukin-12; D000637:Transaminases |
Accuracy of Femoral Tunnel Localization With Mixed Reality Technology-Assisted Single-Bundle ACL Reconstruction. | Background
It is clinically challenging to accurately drill femoral and tibial tunnels to reconstruct the anterior cruciate ligament (ACL). Mixed reality (MR) technology, a further development of virtual reality technology, presents virtual scene information in real time and establishes an interactive feedback informat... | 10.1177/23259671231184399 | 37,457,048 | Orthopaedic journal of sports medicine | 2,023 | ||
Crystal structure of 3-hydroxybenzoate hydroxylase from Comamonas testosteroni has a large tunnel for substrate and oxygen access to the active site. | The 3-hydroxybenzoate hydroxylase (MHBH) from Comamonas testosteroni KH122-3s is a single-component flavoprotein monooxygenase, a member of the glutathione reductase (GR) family. It catalyzes the conversion of 3-hydroxybenzoate to 3,4-dihydroxybenzoate with concomitant requirements for equimolar amounts of NADPH and mo... | 10.1016/j.jmb.2006.09.031 | 17,045,293 | D000595:Amino Acid Sequence; D001665:Binding Sites; D002384:Catalysis; D020604:Comamonas testosteroni; D018360:Crystallography, X-Ray; D062385:Hydroxybenzoates; D006900:Hydroxylation; D006899:Mixed Function Oxygenases; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009249:NADP; D010100:Oxygen; D011485:Pro... | Journal of molecular biology | 2,006 | D062385:Hydroxybenzoates; C032948:3-hydroxybenzoic acid; D009249:NADP; D006899:Mixed Function Oxygenases; C021385:3-hydroxybenzoate-4-monooxygenase; D010100:Oxygen |
[Hemodynamic impact of positive end expiratory pressure (PEEP) during severe respiratory failure: present view]. | Bedside evaluation of pulmonary mechanics and thoracic computed axial tomography have changed the ventilatory management of patients suffering an acute respiratory failure caused by adult respiratory distress syndrome (ARDS). Mortality has been reduced limiting tidal volumes, which avoids alveolar overdistention and by... | 12,611,244 | D000328:Adult; D001794:Blood Pressure; D006352:Heart Ventricles; D006439:Hemodynamics; D006801:Humans; D011175:Positive-Pressure Respiration; D012128:Respiratory Distress Syndrome; D012131:Respiratory Insufficiency | Revista medica de Chile | 2,002 | ||
Alternative option for osteogenesis imperfecta and trigeminal neuralgia. | Osteogenesis imperfecta (OI) is a bone disorder that can lead to skull base deformities such as basilar invagination, which can cause compression of cranial nerves, including the trigeminal nerve. Trigeminal neuralgia in such cases remains a challenge, given distorted anatomy and deformities. We present an alternative ... | 10.1590/1806-9282.63.04.307 | 28,614,531 | D000328:Adult; D000792:Angiography; D002404:Catheterization; D005260:Female; D054085:Foramen Ovale; D006801:Humans; D010013:Osteogenesis Imperfecta; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014277:Trigeminal Neuralgia | Revista da Associacao Medica Brasileira (1992) | 2,017 | |
Evaluation of NOx in the cardiovascular system: relationship to NO-related compounds in vivo. | Diverse attention should be paid to evaluating NOx (NO2- and NO3-) in plasma as an index of endothelial nitric oxide (NO) formation in vivo. Nitric oxide, which subsequently appears as NOx, originates from different types of NO synthase and from nonenzymatic reactions. NOx also comes from exogenous sources such as food... | 10.1254/jjp.81.317 | 10,669,035 | D000818:Animals; D002319:Cardiovascular System; D004730:Endothelium, Vascular; D006801:Humans; D009566:Nitrates; D009569:Nitric Oxide; D009573:Nitrites | Japanese journal of pharmacology | 1,999 | D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide |
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