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Genetic predisposition to atorvastatin-induced myopathy: a case report. | WHAT IS KNOWN AND OBJECTIVE
The major clinical complication of statins is a variety of muscle complaints ranging from myalgia to rhabdomyolysis. There is growing evidence that carriers of genetic polymorphisms in the enzymes and transporters implicated in statin disposition, particularly the SLCO1B1 gene, are at increa... | 10.1111/j.1365-2710.2012.01337.x | 22,582,980 | D000368:Aged; D000069059:Atorvastatin; D003324:Coronary Artery Disease; D020022:Genetic Predisposition to Disease; D006538:Heptanoic Acids; D006801:Humans; D027381:Liver-Specific Organic Anion Transporter 1; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases; D027361:Organic Anion Transporters; D011110:Polymo... | Journal of clinical pharmacy and therapeutics | 2,012 | D006538:Heptanoic Acids; D027381:Liver-Specific Organic Anion Transporter 1; D027361:Organic Anion Transporters; D011758:Pyrroles; C503999:SLCO1B1 protein, human; D000069059:Atorvastatin |
Regulation of Fc gamma R II expression and function by B lymphocyte activators. | B lymphocytes cultured with LPS show increased expression of Fc gamma R II and increased binding of Ag-IgG complexes (both greater than 200%). In contrast, B lymphocytes cultured with either IL-4 or anti-mu show a marked loss (85-90%) of binding of Ag-IgG complexes that is specific, time and temperature dependent, and ... | 10.1016/0161-5890(90)90021-q | 2,148,803 | D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000943:Antigens, Differentiation; D001402:B-Lymphocytes; D002460:Cell Line; D005260:Female; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D006098:Granulocytes; D007074:Immunoglobulin G; ... | Molecular immunology | 1,990 | D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000943:Antigens, Differentiation; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008070:Lipopolysaccharides; D011961:Receptors, Fc; D017452:Receptors, IgG; D015847:Interleukin-4; D007371:Interferon-gamma |
What do we (not) know theoretically about solar neutrino fluxes? | Solar model predictions of 8B and p-p neutrinos agree with the experimentally determined fluxes (including oscillations): phi(pp)(measured)=(1.02+/-00.02+/-0.01)phi(pp)(theory) and phi(8B)(measured)=(0.88+/-0.04+/-0.23)phi(8B)(theory), 1sigma experimental and theoretical uncertainties, respectively. We use improved inp... | 10.1103/PhysRevLett.92.121301 | 15,089,662 | Physical review letters | 2,004 | ||
Lower extremity manifestations of spasticity in chronic spinal cord injury. | The prevalence of various manifestations of spasticity from questionnaire responses and from clinical examination of chronic spinal cord injured patients is reported. Extensor spasms, flexor withdrawal spasms, and clonus were reported by most subjects. Those with incomplete lesions reported more interference with activ... | 10.1097/00002060-198902000-00009 | 2,917,056 | D000328:Adult; D000368:Aged; D006801:Humans; D007537:Isometric Contraction; D007866:Leg; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity; D009129:Muscle Tonus; D009132:Muscles; D009207:Myoclonus; D010264:Paraplegia; D011782:Quadriplegia; D012026:Reflex, Stretch; D013035:Spasm; D013116:Spinal Cord; D013119:... | American journal of physical medicine & rehabilitation | 1,989 | |
Rapid and selective enzymatic debridement of porcine comb burns with bromelain-derived Debrase: acute-phase preservation of noninjured tissue and zone of stasis. | Deep burns are associated with the formation of an eschar, which delays healing and increases the risk of infection. Surgical debridement of the eschar is, at present, the fastest means to achieve an eschar-free bed, but the process can not differentiate between the viable tissue and the eschar and follow the minute ir... | 10.1097/BCR.0b013e3181d0f4d4 | 20,182,376 | D000818:Animals; D001963:Bromelains; D002056:Burns; D016009:Chi-Square Distribution; D003646:Debridement; D004195:Disease Models, Animal; D005260:Female; D005782:Gels; D009336:Necrosis; D009779:Occlusive Dressings; D011446:Prospective Studies; D012837:Silver Sulfadiazine; D013552:Swine; D014945:Wound Healing | Journal of burn care & research : official publication of the American Burn Association | 2,010 | D005782:Gels; D001963:Bromelains; D012837:Silver Sulfadiazine |
Combination resonance and primary resonance characteristics of a dual-rotor system under the condition of the synchronous impact of the inter-shaft bearing. | The internal structure of many aero-engines is designed with a dual-rotor system. Up to now, there have been few studies on the influence of aerodynamic excitation on the dual-rotor system. The phenomenon of synchronous impact may occur when the frequency of the aerodynamic excitation force of the fan blade is close to... | 10.1038/s41598-023-27922-8 | 36,670,133 | Scientific reports | 2,023 | ||
Amisulpride treatment of adolescent patients with schizophrenia or schizo-affective disorders. | In this article, our aim was to share our clinical experience regarding the effectiveness and the side effects of amisulpride treatment in adolescent cases. We reviewed all the cases who had amisulpride treatment during their stay in a newly opened in-patient unit, and three female cases who had undergone amisulpride t... | 10.1007/s00787-009-0009-8 | 19,267,176 | D000293:Adolescent; D000077582:Amisulpride; D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D001712:Biperiden; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D016903:Drug Monitoring; D004359:Drug Therapy, Combination; D005260:Female; D005687:Galactorrhea; D006801:Humans; D01... | European child & adolescent psychiatry | 2,009 | D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D001712:Biperiden; D013469:Sulpiride; D000077582:Amisulpride |
Improvement of aromatic thiol release through the selection of yeasts with increased β-lyase activity. | The development of a selective medium for the rapid differentiation of yeast species with increased aromatic thiol release activity has been achieved. The selective medium was based on the addition of S-methyl-l-cysteine (SMC) as β-lyase substrate. In this study, a panel of 245 strains of Saccharomyces cerevisiae strai... | 26,971,012 | D013437:Carbon-Sulfur Lyases; D003470:Culture Media; D003545:Cysteine; D005285:Fermentation; D005516:Food Microbiology; D008401:Gas Chromatography-Mass Spectrometry; D008190:Lyases; D016533:Mycological Typing Techniques; D012441:Saccharomyces cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D013438:Sulfhydryl Com... | International journal of food microbiology | 2,016 | D003470:Culture Media; D029701:Saccharomyces cerevisiae Proteins; D013438:Sulfhydryl Compounds; D008190:Lyases; D013437:Carbon-Sulfur Lyases; C000607133:Irc7 protein, S cerevisiae; D003545:Cysteine | |
[Effects of a thoracic paravertebral block on postoperative analgesia in patients undergoing modified radical mastectomy]. | OBJECTIVES
Following mastectomy, 50% of patients have chronic postoperative pain. Studies have shown that a paravertebral block is an effective method of analgesia as well as anaesthesia. The aim of this study is to compare postoperative pain values and opioid consumption after a single dose of 150 mg levobupivacaine w... | 10.5505/agri.2014.65982 | 25,551,814 | D000328:Adult; D000762:Anesthesia Recovery Period; D000779:Anesthetics, Local; D002045:Bupivacaine; D005260:Female; D006801:Humans; D000077554:Levobupivacaine; D015411:Mastectomy, Modified Radical; D008875:Middle Aged; D009407:Nerve Block; D010147:Pain Measurement; D010149:Pain, Postoperative; D013904:Thoracic Vertebra... | Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology | 2,014 | D000779:Anesthetics, Local; D000077554:Levobupivacaine; D002045:Bupivacaine |
Effects of treatment intensification on acute local toxicity during radiotherapy for head and neck cancer: prospective observational study validating CTCAE, version 3.0, scoring system. | PURPOSE
To quantify the incidence and severity of acute local toxicity in head and neck cancer patients treated with radiotherapy (RT), with or without chemotherapy (CHT), using the Common Terminology Criteria for Adverse Events, version 3.0 (CTCAE v3.0), scoring system.
METHODS AND MATERIALS
Between 2004 and 2006, 1... | 10.1016/j.ijrobp.2007.06.022 | 17,881,148 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D003680:Deglutition Disorders; D019583:Dose Fractionation, Radiation; D005260:Female; D006258:Head and Neck Neoplasms; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010146:P... | International journal of radiation oncology, biology, physics | 2,008 | |
[Tubulo-interstitial fibrosis: an emerging major health problem]. | The incidence of chronic kidney disease leading to end-stage renal disease has significantly increased and may reach epidemic proportions over the next decade. Regardless of the initial insult, the progression of most forms of renal disease results in tubulo-interstitial fibrosis. This has been closely correlated to th... | 10.1051/medsci/201127155 | 21,299,963 | D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D015687:Cell Hypoxia; D018925:Chemokines; D016207:Cytokines; D018450:Disease Progression; D005109:Extracellular Matrix; D005347:Fibroblasts; D006801:Humans; D015994:Incidence; D036341:Intercellular Signaling Pep... | Medecine sciences : M/S | 2,011 | D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D018925:Chemokines; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D008246:Lysophospholipids; C032881:lysophosphatidic acid |
Distributed networks for auditory memory differentially contribute to recall precision. | Re-directing attention to objects in working memory can enhance their representational fidelity. However, how this attentional enhancement of memory representations is implemented across distinct, sensory and cognitive-control brain network is unspecified. The present fMRI experiment leverages psychophysical modelling ... | 10.1016/j.neuroimage.2022.119227 | 35,452,804 | D001921:Brain; D001931:Brain Mapping; D006801:Humans; D008279:Magnetic Resonance Imaging; D008570:Memory, Short-Term; D010897:Pitch Discrimination | NeuroImage | 2,022 | |
Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. | BACKGROUND
Continuous veno-venous haemofiltration is increasingly used to treat acute renal failure in critically ill patients, but a clear definition of an adequate treatment dose has not been established. We undertook a prospective randomised study of the impact of different ultrafiltration doses in continuous renal ... | 10.1111/j.1755-6686.2002.tb00248.x | 12,371,727 | D018806:APACHE; D058186:Acute Kidney Injury; D001806:Blood Urea Nitrogen; D001835:Body Weight; D003404:Creatinine; D005260:Female; D006440:Hemofiltration; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D020127:Recovery of Function; D016019:Survival A... | EDTNA/ERCA journal (English ed.) | 2,002 | D003404:Creatinine |
Prospective Evaluation of Universal BRCA Testing for Women With Triple-Negative Breast Cancer. | BACKGROUND
Limited published literature exists on women with triple-negative breast cancer (TNBC) diagnosed over the age of 60 years with breast cancer gene (BRCA) pathogenic variants. Our study determined whether the rate of BRCA pathogenic variants in a prospective cohort of TNBC patients outside the definition of cu... | 10.1093/jncics/pkaa002 | 32,211,581 | JNCI cancer spectrum | 2,020 | ||
Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis. | The objective of our study was to perform an updated meta-analysis of placebo-controlled RCTs of Huperzine A (Hup A) on patients with Alzheimer's disease (AD) and vascular dementia (VD), in order to provide the basis and reference for clinical rational drug use. The primary outcome measures assessed were minimental sta... | 10.1155/2014/363985 | 24,639,880 | Evidence-based complementary and alternative medicine : eCAM | 2,014 | ||
[Comparative analysis of the sensitivity to natural killers and macrophages of 3-methylcholanthrene-induced tumors in mice]. | The sensitivity of 3 primary and 13 continuous tumour cell cultures 11 of which were induced with 20-methylcholanthrene to natural killer cells and cytotoxic macrophages has been tested. It is shown that the sensitivity of target cells varies markedly to both types of effector cells and that the level of susceptibility... | 3,803,287 | D000818:Animals; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D007113:Immunity, Innate; D007694:Killer Cells, Natural; D008213:Lymphocyte Activation; D008264:Macrophages; D008748:Methylcholanthrene; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009368:N... | Eksperimental'naia onkologiia | 1,986 | D008748:Methylcholanthrene | |
Psychopathology and accidental injuries. | One hundred and twelve adults admitted to a surgical ward due to accidental injuries were studied. Thirty-seven percent had a psychiatric disorder on admission (DSM-III axis I) and 21% had a personality disorder (axis 2). Substance abuse and dependence and antisocial personality disorders were most frequent. Eighteen p... | 10.1111/j.1600-0447.1987.tb02894.x | 3,673,653 | D000059:Accidents; D000293:Adolescent; D000328:Adult; D000368:Aged; D003674:Defense Mechanisms; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders; D008875:Middle Aged; D010554:Personality Disorders; D011446:Prospective Studies; D014947:Wounds and Injuries | Acta psychiatrica Scandinavica | 1,987 | |
Role of proteolysis in determining potency of Bacillus thuringiensis Cry1Ac delta-endotoxin. | Bacillus thuringiensis protein delta-endotoxins are toxic to a variety of different insect species. Larvicidal potency depends on the completion of a number of steps in the mode of action of the toxin. Here, we investigated the role of proteolytic processing in determining the potency of the B. thuringiensis Cry1Ac del... | 10.1128/AEM.66.12.5174-5181.2000 | 11,097,886 | D000595:Amino Acid Sequence; D000818:Animals; D001413:Bacillus thuringiensis; D000083722:Bacillus thuringiensis Toxins; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D001483:Base Sequence; D002080:Butterflies; D017931:DNA Primers; D010450:Endopeptidases; D004731:Endotoxins; D006460:Hemolysin Proteins; D007814:L... | Applied and environmental microbiology | 2,000 | D000083722:Bacillus thuringiensis Toxins; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D017931:DNA Primers; D004731:Endotoxins; D006460:Hemolysin Proteins; C030956:insecticidal crystal protein, Bacillus Thuringiensis; D010450:Endopeptidases |
A high-affinity ammonium transporter from the mycorrhizal ascomycete Tuber borchii. | An ammonium transporter cDNA, named TbAMT1, was isolated from the ectomycorrhizal ascomycetous truffle Tuber borchii. The polypeptide encoded by TbAMT1 (52 kDa) functionally complements ammonium uptake-defective yeast mutants and shares sequence similarity with previously characterized ammonium transporters from Saccha... | 10.1016/S1087-1845(02)00001-4 | 12,051,892 | D000595:Amino Acid Sequence; D001203:Ascomycota; D001483:Base Sequence; D002352:Carrier Proteins; D027682:Cation Transport Proteins; D018076:DNA, Complementary; D004271:DNA, Fungal; D005656:Fungal Proteins; D005800:Genes, Fungal; D005816:Genetic Complementation Test; D007700:Kinetics; D008958:Models, Molecular; D008969... | Fungal genetics and biology : FG & B | 2,002 | D002352:Carrier Proteins; D027682:Cation Transport Proteins; D018076:DNA, Complementary; D004271:DNA, Fungal; D005656:Fungal Proteins; D010940:Plant Proteins; D000644:Quaternary Ammonium Compounds; D012331:RNA, Fungal; D012333:RNA, Messenger; C088952:ammonium transporters, plant |
Efficacy of argon-helium cryoablation and its effects on immune function of patients with neck malignant tumours. | OBJECTIVES
Our study aimed to investigate the clinical efficacy of argon-helium cryoablation and its effects on the immune function of patients with neck malignant tumours.
DESIGN
Retrospective study.
SETTING
Single-institution academic tertiary care centre.
METHODS
Totally, 180 patients harbouring head and neck ... | 10.1111/coa.13648 | 32,920,994 | D000328:Adult; D001128:Argon; D002097:C-Reactive Protein; D016516:CD4-CD8 Ratio; D002277:Carcinoma; D003452:Cryosurgery; D005260:Female; D006258:Head and Neck Neoplasms; D006371:Helium; D006801:Humans; D053583:Interleukin-1beta; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome... | Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery | 2,021 | D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D006371:Helium; D001128:Argon; D002097:C-Reactive Protein |
New advances in imaging osteoporosis and its complications. | Tremendous advances have been made over the past several decades in assessing osteoporosis and its complications. High resolution imaging combined with sophisticated computational techniques now provide a detailed analysis of bone structure and a much more accurate prediction of bone strength. These techniques have sho... | 10.1007/s12020-012-9691-2 | 22,618,377 | D015502:Absorptiometry, Photon; D054893:Cone-Beam Computed Tomography; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010024:Osteoporosis; D014057:Tomography, X-Ray Computed | Endocrine | 2,012 | |
Coordinating centers in cancer epidemiology research: the Asia Cohort Consortium coordinating center. | Although it is tacitly recognized that a good coordinating center (CC) is essential to the success of any multisite collaborative project, very little study has been done on what makes a CC successful, why some CCs fail, or how to build a CC that meets the needs of a given project. Moreover, very little published guida... | 10.1158/1055-9965.EPI-11-0391 | 21,803,842 | D001208:Asia; D035843:Biomedical Research; D006801:Humans; D009369:Neoplasms | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology | 2,011 | |
[Research progress of mesenchymal stem cells in burn wound repair]. | OBJECTIVE
To review the research progress of mesenchymal stem cells (MSCs) in burn wound repair.
METHODS
The recent literature about MSCs involved in burn wound repair and mechanism was extensively reviewed and analyzed.
RESULTS
MSCs have the capacity of self-renew, rapid proliferation, differentiation and paracrin... | 23,879,094 | D000818:Animals; D002056:Burns; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D002478:Cells, Cultured; D016207:Cytokines; D005347:Fibroblasts; D006801:Humans; D008214:Lymphocytes; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells; D018919:Neovascularization... | Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | 2,013 | D016207:Cytokines | |
Dysequilibrium of ageing (presbyastasis). | We reviewed clinical findings in 740 patients over age 65 who consulted the Otological Medical Group, Inc., during a one-year period for dizziness. A thorough neurotologic evaluation is indicated in every such case to determine the specific cause of dizziness. In 21 per cent of these patients, a specific cause of dizzi... | 10.1017/s0022215100100520 | 3,760,685 | D000368:Aged; D000375:Aging; D004244:Dizziness; D006801:Humans; D009525:Niacin; D013701:Temporal Bone | The Journal of laryngology and otology | 1,986 | D009525:Niacin |
Relations between blood pressure and plasma norepinephrine concentrations after administration of diltiazem to rats: HPLC-peroxyoxalate chemiluminescence determination on an individual basis. | A calcium antagonist, diltiazem, was infused continuously into Sprague-Dawley rats through the left femoral vein at four different flow rates. The mean arterial blood pressure and concentrations of plasma norepinephrine (NE) were measured in each single rat (n = 5) and the correlations between them were studied. Blood ... | 10.1002/bmc.1130080105 | 8,130,627 | D000818:Animals; D001794:Blood Pressure; D002851:Chromatography, High Pressure Liquid; D004110:Diltiazem; D008163:Luminescent Measurements; D009638:Norepinephrine; D010070:Oxalates; D051381:Rats; D017207:Rats, Sprague-Dawley | Biomedical chromatography : BMC | 1,994 | D010070:Oxalates; C044622:peroxyoxalate; D004110:Diltiazem; D009638:Norepinephrine |
Gaze-evoked amaurosis heralding orbital angiomyoma. Case report. | The unusual case of a patient presenting with gaze-evoked amaurosis as an early and isolated sign of orbital angiomyoma is reported. Computed tomography or magnetic resonance of the orbits need to be expeditiously performed in patients with gaze-evoked amaurosis in order to identify or rule out the possible presence of... | 10.1007/BF02106227 | 9,115,040 | D018229:Angiomyoma; D001766:Blindness; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009918:Orbital Neoplasms; D014057:Tomography, X-Ray Computed | Italian journal of neurological sciences | 1,997 | |
[Experimental study of compomer sealant with non-rinse conditioner used on permanent molar]. | OBJECTIVE
To compare the microleakage of compomer sealant with non-rinse conditioner and resin sealant with phosphoric acid (35%) by dye test and scanning electron microscope (SEM) observation.
METHODS
16 extracted third permanent molars were divided into 4 groups: Group I, non-rinse conditioner (NRC) + Prime & Bond ... | 18,306,626 | D000134:Acid Etching, Dental; D020770:Compomers; D001840:Dental Bonding; D017220:Dentin-Bonding Agents; D006801:Humans; D008298:Maleates; D008963:Molar; D010756:Phosphoric Acids; D011109:Polymethacrylic Acids | Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology | 2,007 | D020770:Compomers; D017220:Dentin-Bonding Agents; D008298:Maleates; D010756:Phosphoric Acids; D011109:Polymethacrylic Acids; C425843:Prime and Bond NT; C496147:dyract seal; C444699:non-rinse conditioner; C030242:phosphoric acid | |
Renal carcinoid tumor: An immunohistochemical and molecular genetic study of four cases. | Few genetic studies of renal carcinoid tumor have been conducted thus far. We performed immunohistochemical and genetic examinations on four renal carcinoid tumors. Histologically, the tumors consisted of neoplastic cells with round to oval nuclei. Various growth patterns such as tightly packed cords and trabeculae, ri... | 10.3892/ol_00000015 | 22,966,261 | Oncology letters | 2,010 | ||
A survey of specialist and advanced nursing practice in England. | This report is the result of a 1-year research project which aimed to develop a contemporary account of the expectations of senior personnel in 371 NHS trusts in England with regard to specialist and advanced nursing roles. The main findings covered employment issues, work activities and fields of practice. This study ... | 10.12968/bjon.1996.5.11.682 | 8,845,676 | D004651:Employment; D004739:England; D006801:Humans; D007587:Job Description; D009718:Nurse Administrators; D009720:Nurse Clinicians; D009722:Nurse Practitioners; D017009:Professional Autonomy; D011795:Surveys and Questionnaires | British journal of nursing (Mark Allen Publishing) | 1,996 | |
Poly-isoprenylated ifosfamide analogs: Preactivated antitumor agents as free formulation or nanoassemblies. | Oxazaphosphorines including cyclophosphamide, trofosfamide and ifosfamide (IFO) belong to the alkylating agent class and are indicated in the treatment of numerous cancers. However, IFO is subject to limiting side-effects in high-dose protocols. To circumvent IFO drawbacks in clinical practices, preactivated IFO analog... | 10.1016/j.ijpharm.2017.05.044 | 28,546,071 | D000818:Animals; D018906:Antineoplastic Agents, Alkylating; D045744:Cell Line, Tumor; D002470:Cell Survival; D006801:Humans; D007069:Ifosfamide; D008297:Male; D020714:Maximum Tolerated Dose; D008819:Mice, Nude; D049329:Nanostructures; D054876:Prenylation | International journal of pharmaceutics | 2,017 | D018906:Antineoplastic Agents, Alkylating; D007069:Ifosfamide |
Ecosystem responses to exotic earthworm invasion in northern North American forests. | Earth is experiencing a substantial loss of biodiversity at the global scale, while both species gains and losses are occurring at local and regional scales. The influence of these nonrandom changes in species distributions could profoundly affect the functioning of ecosystems and the essential services that they provi... | 10.3897/rio.5.e34564 | 31,032,397 | Research ideas and outcomes | 2,019 | ||
Does breast feeding provide protection against acute appendicitis? A case-control study. | Breast feeding stimulates a more tolerant lymphoid tissue at the base of the appendix and this could provide protection against acute appendicitis. Two studies reported that children and adolescents with appendicitis were less likely to have been breast fed. In a case-control study of 200 children with histologically c... | 10.1258/td.2008.070404 | 18,820,196 | D000208:Acute Disease; D000293:Adolescent; D001064:Appendicitis; D001942:Breast Feeding; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D008297:Male | Tropical doctor | 2,008 | |
Sociodemographic factors associated with paediatric out-of-hospital cardiac arrest: A systematic review. | BACKGROUND
Paediatric out-of-hospital cardiac arrest (POHCA) is associated with poor survival and severe neurological sequelae. We conducted a systematic review on the impact of sociodemographic factors across different stages of POHCA.
METHODS
We searched MEDLINE, EMBASE, and Web of Science from database inception t... | 10.1016/j.resuscitation.2023.109931 | 37,562,664 | D006801:Humans; D002648:Child; D016887:Cardiopulmonary Resuscitation; D058687:Out-of-Hospital Cardiac Arrest; D000091569:Sociodemographic Factors; D000359:Aftercare; D010351:Patient Discharge; D004632:Emergency Medical Services | Resuscitation | 2,023 | |
Extracorporeal Shockwave Therapy for Chronic Knee Pain: A Multicenter, Randomized Controlled Trial. | CONTEXT
Osteoarthritis is the leading cause of chronic knee pain (CKP) in older adults. Medical practitioners often manage CKP using both pharmacological and nonpharmacological therapies. However, no studies have specifically focused on extracorporeal shockwave therapy (ESWT) for treatment of CKP.
OBJECTIVE
The resea... | 31,221,934 | D000368:Aged; D018771:Arthralgia; D002681:China; D000074059:Extracorporeal Shockwave Therapy; D006801:Humans; D020370:Osteoarthritis, Knee; D010146:Pain; D016896:Treatment Outcome | Alternative therapies in health and medicine | 2,020 | ||
Pretransmetalation Intermediates in Suzuki-Miyaura Cross-Couplings: Synthesis of Csp-, Csp- and Csp-Organopalladium(II) Boronates. | Organopalladium(II) boronates represent fundamental pretransmetalation intermediates in Suzuki-Miyaura cross-couplings. These species are typically kinetically unstable, making them particularly elusive. In this study, a range of unprecedented, kinetically stable alkyl-, alkenyl-, allenyl-, and alkynylpalladium(II) bor... | 10.1021/acs.inorgchem.3c00198 | 36,946,982 | Inorganic chemistry | 2,023 | ||
Collagen I-matrigel scaffolds for enhanced Schwann cell survival and control of three-dimensional cell morphology. | We report on the ability to control three-dimensional Schwann cell (SC) morphology using collagen I-Matrigel composite scaffolds for neural engineering applications. SCs are supportive of nerve regeneration after injury, and it has recently been reported that SCs embedded in collagen I, a material frequently used in gu... | 10.1089/ten.TEA.2008.0406 | 19,231,925 | D000818:Animals; D000831:Animals, Newborn; D003094:Collagen; D004338:Drug Combinations; D007797:Laminin; D008855:Microscopy, Electron, Scanning; D011509:Proteoglycans; D051381:Rats; D012583:Schwann Cells; D023822:Tissue Engineering; D054457:Tissue Scaffolds | Tissue engineering. Part A | 2,009 | D004338:Drug Combinations; D007797:Laminin; D011509:Proteoglycans; C059485:matrigel; D003094:Collagen |
Regulatory T cells and immunodeficiency in mycosis fungoides and Sézary syndrome. | Cutaneous T-cell lymphoma (CTCL) is the term for diseases characterized by primary accumulation of malignant T cells in the skin. Patients with the two predominant clinical forms of CTCL called mycosis fungoides (MF) and Sézary syndrome (SS) characteristically develop severe immunodeficiency during disease progression ... | 10.1038/leu.2011.237 | 21,904,385 | D000818:Animals; D015704:CD4 Antigens; D051858:Forkhead Transcription Factors; D006801:Humans; D007111:Immunity, Cellular; D053645:Interleukin-2 Receptor alpha Subunit; D009182:Mycosis Fungoides; D012751:Sezary Syndrome; D050378:T-Lymphocytes, Regulatory | Leukemia | 2,012 | D015704:CD4 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D053645:Interleukin-2 Receptor alpha Subunit |
Increased microbicidal activity of green tea (Camellia sinensis) in combination with butylated hydroxyanisole. | We have demonstrated that green tea (Camellia sinensis) shows increased antimicrobial activity against bacteria and fungi when used in combination with butylated hydroxyanisole (BHA). Glycolic extract taken from green tea showed only limited activity against Streptococcus mutans and no activity against Candida albicans... | 10.1179/joc.2004.16.2.122 | 15,216,944 | D000900:Anti-Bacterial Agents; D002083:Butylated Hydroxyanisole; D028241:Camellia sinensis; D002176:Candida albicans; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006090:Gram-Negative Bacteria; D006094:Gram-Positive Bacteria; D006801:Humans; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010... | Journal of chemotherapy (Florence, Italy) | 2,004 | D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D002083:Butylated Hydroxyanisole |
Up-regulation of defense enzymes is responsible for low reactive oxygen species in malignant prostate cancer cells. | Reactive oxygen species (ROS) are involved in a diversity of important phenomena in the process of tumor development. To investigate the alterations of oxidative stress and their related systems in tumor progression, a variety of components in the antioxidative stress defense system were examined in prostate cancer cel... | 10.1038/emm.2005.62 | 16,264,276 | D000975:Antioxidants; D045744:Cell Line, Tumor; D004790:Enzyme Induction; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D011471:Prostatic Neoplasms; D017382:Reactive Oxygen Species; D013880:Thioredoxin-Disulfide Reductase; D015854:Up-Regulation | Experimental & molecular medicine | 2,005 | D000975:Antioxidants; D017382:Reactive Oxygen Species; D013880:Thioredoxin-Disulfide Reductase |
Neurotensin-deficient mice have deficits in prepulse inhibition: restoration by clozapine but not haloperidol, olanzapine, or quetiapine. | Prepulse inhibition (PPI) of the acoustic startle reflex is a commonly used measure of preattentive sensorimotor gating. Disrupted PPI in rodents represents an animal model of the sensorimotor gating deficits characteristic of schizophrenia. The neurotensin (NT) system is implicated in the pathophysiology of schizophre... | 10.1124/jpet.105.087437 | 15,987,829 | D000661:Amphetamine; D000818:Animals; D014150:Antipsychotic Agents; D001569:Benzodiazepines; D001835:Body Weight; D003024:Clozapine; D003987:Dibenzothiazepines; D005260:Female; D006220:Haloperidol; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009496:Neurotensin; D000077152:Olanzapine; D000069348:Quetiapine ... | The Journal of pharmacology and experimental therapeutics | 2,005 | D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D001569:Benzodiazepines; D000069348:Quetiapine Fumarate; D009496:Neurotensin; D000661:Amphetamine; D003024:Clozapine; D006220:Haloperidol; D000077152:Olanzapine |
Genetic basis of triatomine behavior: lessons from available insect genomes. | Triatomines have been important model organisms for behavioural research. Diverse reports about triatomine host search, pheromone communication in the sexual, shelter and alarm contexts, daily cycles of activity, refuge choice and behavioural plasticity have been published in the last two decades. In recent times, a va... | 24,473,804 | D000818:Animals; D001522:Behavior, Animal; D057906:Circadian Clocks; D002940:Circadian Rhythm; D049750:Genome, Insect; D007303:Insect Vectors; D008124:Locomotion; D010675:Pheromones; D012239:Rhodnius; D065854:Spatial Navigation; D014225:Triatominae | Memorias do Instituto Oswaldo Cruz | 2,013 | D010675:Pheromones | |
Synthesis of hollow lantern-like Eu(III)-doped g-C3N4 with enhanced visible light photocatalytic perfomance for organic degradation. | A series of hollow structure lantern-like Eu(III)-doped g-C3N4 (xEu-CN, x = 1, 2, 3) was firstly synthesized by heating a mixture of melamine, HNO3 and Eu2O3 at 500 °C for 2 h. The phase, morphology and optical properties of the serial xEu-CN samples were characterized by different techniques, including TEM, XRD, FT-IR... | 10.1016/j.jhazmat.2018.01.058 | 29,427,973 | Journal of hazardous materials | 2,018 | ||
Schwann cells migrate along axons in the absence of GDNF signaling. | BACKGROUND
During development neural crest derived Schwann Cell (SC) precursors migrate to nerve trunks and populate nascent nerves. Axonal ensheathment by SC is a prerequisite for normal nerve function and the integrity of myelinated as well as nonmyelinated axons. To provide adequate support functions, SC colonize en... | 10.1186/1471-2202-13-92 | 22,863,354 | D000818:Animals; D016590:Aphidicolin; D001369:Axons; D002461:Cell Line, Transformed; D002465:Cell Movement; D049109:Cell Proliferation; D004622:Embryo, Mammalian; D004791:Enzyme Inhibitors; D005260:Female; D051100:Glial Cell Line-Derived Neurotrophic Factor; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors... | BMC neuroscience | 2,012 | D004791:Enzyme Inhibitors; C494988:Gfra1 protein, mouse; D051100:Glial Cell Line-Derived Neurotrophic Factor; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; D006657:Histones; D009418:S100 Proteins; D016590:Aphidicolin; D020932:Nerve Growth Factor; D014446:Tyrosine 3-Monooxygenase |
Characterization and isolation of an intracellular D-mannose-specific receptor from human promyelocytic HL60 cells. | Most mammalian macrophages express D-mannose-specific receptor (membrane lectin, Mr 175,000) allowing endocytosis of their ligands, but cells of the monocytic lineage (HL60, U937, monocyte) lack this receptor. However, after permeabilization, promyelocytic, promonocytic cells and monocytes bound fluoresceinylated D-man... | 10.1016/s0008-6215(00)90601-3 | 1,933,956 | D002846:Chromatography, Affinity; D005434:Flow Cytometry; D019793:Fluorescein; D005452:Fluoresceins; D006801:Humans; D037181:Lectins, C-Type; D015473:Leukemia, Promyelocytic, Acute; D008358:Mannose; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D008970:Molecular Weight; D009000:Monocytes; D011956:Recept... | Carbohydrate research | 1,991 | D005452:Fluoresceins; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D008358:Mannose; D019793:Fluorescein |
[Therapy by endoscopic laser for prostatic obstruction]. | As part of the search for alternatives to transurethral resection of the prostate (TURP) attention has (re)turned to laser methods. We describe our experience with the currently available endoscopic beam deflection devices, particularly the Prolase II. 25 patients, generally with medical reasons to avoid TURP, and with... | 7,516,389 | D000368:Aged; D000369:Aged, 80 and over; D004724:Endoscopy; D006801:Humans; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen; D011470:Prostatic Hyperplasia; D014463:Ultrasonography; D014524:Urethral Obstruction; D014546:Urinary Catheterization; D014563:Urodynamics | Journal d'urologie | 1,993 | D017430:Prostate-Specific Antigen | |
Individual, community and societal correlates of insecticide treated net use among pregnant women in sub-Saharan Africa: a multi-level analysis. | BACKGROUND
Malaria in pregnancy is a crucial public health concern due to the enormous risk it poses to maternal and newborn health. The World Health Organisation therefore recommends insecticide-treated net (ITN) for pregnant women. The world over, sub-Saharan Africa bears the highest prevalence of malaria and its ass... | 10.1186/s12889-021-11635-6 | 34,445,978 | D001499:Bayes Theorem; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D057148:Insecticide-Treated Bednets; D007306:Insecticides; D008297:Male; D008302:Mali; D011247:Pregnancy; D037841:Pregnant Women | BMC public health | 2,021 | D007306:Insecticides |
Acute appendicitis in children: evaluation with US. | During a 4-month period, high-resolution ultrasonography (US) was used to prospectively evaluate 70 children with clinically suspected acute appendicitis. Thirty-five US scans showed a noncompressible appendix with maximal outer diameters greater than 6 mm. This finding was considered positive for the diagnosis of acut... | 10.1148/radiology.176.2.2195594 | 2,195,594 | D000208:Acute Disease; D000293:Adolescent; D001064:Appendicitis; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014463:Ultrasonography | Radiology | 1,990 | |
Atomic force microscopy colloid-probe measurements with explicit measurement of particle-solid separation. | We describe the use of evanescent wave scattering to measure the separation between the surface of a solid and a particle that is attached to an atomic force microscope (AFM) cantilever. Termed evanescent wave atomic force microscopy, our approach involves measuring the intensity of the light scattered from an evanesce... | 10.1021/la0497752 | 15,323,510 | Langmuir : the ACS journal of surfaces and colloids | 2,004 | ||
High resolution scanning electron microscopy in biology: artefacts caused by the nature and mode of application of the coating material. | Results of high resolution secondary electron observations of the haemocyanin molecule from the marine whelk Buccinum undatum are given. The choice of metal used for surface coating of the sample (gold, gold--palladium or carbon/gold--palldium) and the mode of application of this metal (thermal vacuum evaporation or di... | 10.1111/j.1365-2818.1978.tb00093.x | 357,727 | D000818:Animals; D056890:Eukaryota; D006046:Gold; D006433:Hemocyanins; D006652:Histological Techniques; D008855:Microscopy, Electron, Scanning; D010165:Palladium; D012908:Snails | Journal of microscopy | 1,978 | D010165:Palladium; D006046:Gold; D006433:Hemocyanins |
DNA sequence- and conformation-directed positioning of nucleosomes by chromatin-remodeling complexes. | Chromatin-remodeling complexes can translocate nucleosomes along the DNA in an ATP-coupled reaction. This process is an important regulator of all DNA-dependent processes because it determines whether certain DNA sequences are found in regions between nucleosomes with increased accessibility for other factors or wrappe... | 10.1073/pnas.0702430104 | 17,893,337 | D000818:Animals; D001483:Base Sequence; D002843:Chromatin; D004247:DNA; D008322:Mammals; D009690:Nucleic Acid Conformation; D009707:Nucleosomes | Proceedings of the National Academy of Sciences of the United States of America | 2,007 | D002843:Chromatin; D009707:Nucleosomes; D004247:DNA |
Effectiveness of biphasic calcium phosphate block bone substitutes processed using a modified extrusion method in rabbit calvarial defects. | PURPOSE
This study evaluated the mechanical and structural properties of biphasic calcium phosphate (BCP) blocks processed using a modified extrusion method, and assessed their in vivo effectiveness using a rabbit calvarial defect model.
METHODS
BCP blocks with three distinct ratios of hydroxyapatite (HA):tricalcium ... | 10.5051/jpis.2015.45.2.46 | 25,932,338 | Journal of periodontal & implant science | 2,015 | ||
Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids. | Exposure to bacterial endotoxin (lipopolysaccharide, LPS) is quite common and may increase human susceptibility to chemical-induced tissue injury. The purpose of this study was to identify mechanisms by which LPS potentiates lymphoid tissue depletion in B6C3F1 mice exposed to the common food-borne trichothecene mycotox... | 10.1006/taap.2002.9374 | 11,922,776 | D000818:Animals; D017209:Apoptosis; D003345:Corticosterone; D051546:Cyclooxygenase 2; D053938:DNA Fragmentation; D004357:Drug Synergism; D004926:Escherichia coli; D005434:Flow Cytometry; D007213:Indomethacin; D015850:Interleukin-6; D007527:Isoenzymes; D008070:Lipopolysaccharides; D008214:Lymphocytes; D008221:Lymphoid T... | Toxicology and applied pharmacology | 2,002 | D015850:Interleukin-6; D007527:Isoenzymes; D008070:Lipopolysaccharides; D014255:Trichothecenes; D014409:Tumor Necrosis Factor-alpha; D015735:Mifepristone; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; C007262:deoxynivalenol; D003345:Corticosterone; D007213:Indomethacin |
Complex interactions between bacteria and haemosporidia in coinfected hosts: An experiment. | Hosts are typically coinfected by multiple parasite species whose interactions might be synergetic or antagonistic, producing unpredictable physiological and pathological impacts on the host. This study shows the interaction between Plasmodium spp. and Leucocytozoon spp. in birds experimentally infected or not infected... | 10.1002/ece3.6318 | 32,607,191 | Ecology and evolution | 2,020 | ||
MRI derived brain atrophy in PSP and MSA-P. Determining sample size to detect treatment effects. | Progressive supranuclear palsy (PSP) and multiple system (MSA) atrophy are associated with progressive brain atrophy. Serial MRI can be applied in order to measure this change in brain volume and to calculate atrophy rates. We evaluated MRI derived whole brain and regional atrophy rates as potential markers of progress... | 10.1007/s00415-006-0396-4 | 17,401,522 | D000368:Aged; D001921:Brain; D002552:Cerebral Ventricles; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy; D012720:Severity of Illness Index;... | Journal of neurology | 2,007 | |
Double-blind crossover trial of progabide versus placebo in severe epilepsies. | In this double-blind, two-period, crossover trial with randomized treatment assignment, progabide (+/- 30 mg/kg/day) and placebo were compared as add-on to standard therapy in 20 "therapy-resistant" epileptic patients (11 males, nine females; age range, 7-47 years). The duration of each treatment period was 6 weeks. Cr... | 10.1111/j.1528-1157.1983.tb04633.x | 6,357,772 | D000293:Adolescent; D000328:Adult; D002648:Child; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004827:Epilepsy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D005680:gamma-Aminobutyric Acid | Epilepsia | 1,983 | D010919:Placebos; C017985:progabide; D005680:gamma-Aminobutyric Acid |
Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor. | The OVCA1 gene is a candidate for the breast and ovarian tumor suppressor gene at chromosome 17p13.3. To help determine the function(s) of OVCA1, we used a yeast two-hybrid screening approach to identify OVCA1-associating proteins. One such protein, which we initially referred to as BOV-1 (binder of OVCA1-1) is 173 or ... | 10.1006/geno.2000.6315 | 11,013,075 | D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D002895:Chromosomes, Human, Pair 5; D003001:Cloning, Molecular; D017124:Conserved Sequence; D018076:DNA, Complementary; D005260:Female; D015870:Gene Expression; D0... | Genomics | 2,000 | D018076:DNA, Complementary; C121987:DPH1 protein, human; D015778:Minor Histocompatibility Antigens; D020033:Protein Isoforms; D011506:Proteins; C406243:RBM8A protein, human; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D025521:Tumor Suppressor Proteins |
Population genetic structure and molecular diversity of Leucinodes orbonalis based on mitochondrial COI gene sequences. | Leucinodes orbonalis is a destructive pest found throughout eggplant cultivating fields of Tamil Nadu, India. The genetic diversity and its population structure were investigated in this pest using mitochondrial cytochrome c oxidase subunit I (COI) gene sequences from 20 populations of L. orbonalis collected from vario... | 10.1080/24701394.2018.1436169 | 29,421,947 | D000818:Animals; D003576:Electron Transport Complex IV; D017344:Genes, Insect; D006239:Haplotypes; D007915:Lepidoptera; D058974:Phylogeography; D011110:Polymorphism, Genetic | Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis | 2,018 | D003576:Electron Transport Complex IV |
Deficient Pain Modulation in Patients with Chronic Hemiplegic Shoulder Pain. | BACKGROUND
Hemiplegic shoulder pain (HSP) following stroke significantly affects the individual's function and quality of life. The mechanism of HSP is not clearly understood; hence, it is unclear why HSP resolves spontaneously or following routine care in some patients, while in others it becomes persistent. The aim w... | 10.1111/papr.12658 | 29,136,315 | D000368:Aged; D005260:Female; D006429:Hemiplegia; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D020069:Shoulder Pain; D020521:Stroke | Pain practice : the official journal of World Institute of Pain | 2,018 | |
Prophylactic use of pegfilgrastim in patients treated with a nitrosourea and teniposide for recurrent glioma. | STUDY OBJECTIVE
As chemotherapy with teniposide and a nitrosourea is commonly used for the treatment of patients with recurrent glioma but can be associated with severe myelotoxicity, we sought to determine if prophylactic administration of pegfilgrastim could reduce leukopenia or infectious complications in patients r... | 10.1002/phar.1409 | 24,619,825 | D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols; D003141:Communicable Diseases; D018572:Disease-Free Survival; D005260:Female; D000069585:Filgrastim; D005858:Germany; D005910:Glioma; D016179:Granulocyte Colony-Stimulating Factor; D006801:Humans; D007970:Leukopenia; D008130:Lomustine;... | Pharmacotherapy | 2,014 | D011994:Recombinant Proteins; D015376:Nimustine; D016179:Granulocyte Colony-Stimulating Factor; C455861:pegfilgrastim; D011092:Polyethylene Glycols; D008130:Lomustine; D013713:Teniposide; D000069585:Filgrastim |
Gene expression of steroidogenic enzymes in chicken embryonic gonads. | This paper reviews the molecular aspects of sex differentiation in birds and describes the sex-reversal effects of aromatase inhibitor on mRNA expression of steroidogenic enzymes. Although it is unknown whether the sex-determining gene resides in the W chromosome or whether a gene-dosage mechanism is involved in sex de... | 9,662,831 | D000818:Animals; D001141:Aromatase; D047072:Aromatase Inhibitors; D002642:Chick Embryo; D017316:Fadrozole; D005260:Female; D015870:Gene Expression; D006066:Gonads; D008297:Male; D012333:RNA, Messenger; D019849:Sex Determination Processes; D012733:Sex Differentiation; D013254:Steroid 17-alpha-Hydroxylase | The Journal of experimental zoology | 1,998 | D047072:Aromatase Inhibitors; D012333:RNA, Messenger; D001141:Aromatase; D013254:Steroid 17-alpha-Hydroxylase; D017316:Fadrozole | |
Ultrafast optical spectroscopy of large-momentum excitons in GaAs. | Highly energetic excitons with wave vectors much larger than that of an absorbed photon are excited in thin GaAs films. We observe propagation beats between three polariton modes up to 300 meV above the absorption edge employing femtosecond transmission spectroscopy. The dispersion relations of the coherent excitations... | 10.1103/PhysRevLett.84.5812 | 10,991,061 | Physical review letters | 2,000 | ||
Alendronate treatment promotes bone formation with a less anisotropic microstructure during intramembranous ossification in rats. | There are safety concerns regarding administration of bisphosphonates to children. Little is known about the effects of bisphosphonates on bone matrix organization during bone modeling. The present study examined the effects of alendronate (ALN) on bone matrices formed by intramembranous ossification in the appendicula... | 10.1007/s00774-007-0782-8 | 18,095,060 | D019386:Alendronate; D000818:Animals; D016880:Anisotropy; D001696:Biomechanical Phenomena; D001846:Bone Development; D001857:Bone Matrix; D018483:Diaphyses; D005260:Female; D036103:Nanotechnology; D010012:Osteogenesis; D051381:Rats; D017207:Rats, Sprague-Dawley | Journal of bone and mineral metabolism | 2,008 | D019386:Alendronate |
Differential genomic arrangements in Caryophyllales through deep transcriptome sequencing of A. hypochondriacus. | Genome duplication event in edible dicots under the orders Rosid and Asterid, common during the oligocene period, is missing for species under the order Caryophyllales. Despite this, grain amaranths not only survived this period but display many desirable traits missing in species under rosids and asterids. For example... | 10.1371/journal.pone.0180528 | 28,786,999 | D027721:Amaranthus; D027461:Beta vulgaris; D016000:Cluster Analysis; D019295:Computational Biology; D050939:Gene Fusion; D005807:Genes, Overlapping; D056426:Genetic Loci; D018745:Genome, Plant; D059014:High-Throughput Nucleotide Sequencing; D008239:Lysine; D010641:Phenotype; D010940:Plant Proteins; D012639:Seeds; D0173... | PloS one | 2,017 | D010940:Plant Proteins; D000520:alpha-Glucosidases; D008239:Lysine |
A Sea Cucumber Homolog of the Mouse T-Brain-1 is Expressed in the Invaginated Cells of the Early Gastrula in Holothuria leucospilota. | A cDNA clone for a sea cucumber T-box gene was isolated and characterized. Based on molecular phylogenetic analysis it is concluded that the putative gene Hl-Tbr, encoded by the cDNA clone, is a T-box gene of the T-brain subfamily and hence a homolog of the mouse T-brain-1 (Tbr-1) as well as of the Xenopus Eomesodermin... | 10.2108/jsz.17.383 | 18,494,594 | Zoological science | 2,000 | ||
Therapeutic Drug Monitoring of Busulfan for the Management of Pediatric Patients: Cross-Validation of Methods and Long-Term Performance. | BACKGROUND
Busulfan (Bu) is an alkylating agent used as part of the conditioning regimen in pediatric patients before hematopoietic stem cell transplantation. Despite intravenous (IV) administration and dosing recommendations based on age and weight, reports have revealed interindividual variability in Bu pharmacokinet... | 10.1097/FTD.0000000000000468 | 29,189,665 | D000477:Alkylating Agents; D002066:Busulfan; D002648:Child; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D004355:Drug Stability; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D011786:Quality Control; D015203:Reproducibility of Result... | Therapeutic drug monitoring | 2,018 | D000477:Alkylating Agents; D002066:Busulfan |
Anti-Inflammatory, Anti-Arthritic and Anti-Nociceptive Activities of Nigella sativa Oil in a Rat Model of Arthritis. | This study investigated the preventive efficacy of the crude oil extracted from Nigella sativa seeds in a rat model of arthritis induced by using complete Freund's adjuvant (CFA). Nigella sativa oil at 1.82 mL/kg or 0.91 mL/kg (corresponding to 1596 and 798 mg/kg, respectively) was orally administered for 25 days from ... | 10.3390/antiox8090342 | 31,450,670 | Antioxidants (Basel, Switzerland) | 2,019 | ||
Interferometry-based Kolsky bar apparatus. | A new experimental approach of the Kolsky bar system using optical interferometry is presented for determination of dynamic behavior of materials. Conventional measurements in the Kolsky bar system are based on recording the strain histories on the incident and transmitter bars with two strain gauges, and require good ... | 10.1063/1.3615243 | 21,806,200 | The Review of scientific instruments | 2,011 | ||
Site specific immobilization of a potent antimicrobial peptide onto silicone catheters: evaluation against urinary tract infection pathogens. | Bacterial colonization of urinary catheters is a common problem leading to Catheter Associated Urinary Tract Infections (CAUTIs) in patients, which result in high treatment costs and associated complications. Due to the advantages of antimicrobial peptides (AMPs) compared to most other antimicrobial molecules, an incre... | 10.1039/c3tb21300e | 32,261,400 | Journal of materials chemistry. B | 2,014 | ||
Differential activation of microglia and astrocytes in aniso- and isomorphic gliotic tissue. | Reactive astrocytes and microglial cells are both involved in the formation of gliotic tissue. Using immunohistochemical markers, we have compared the response of both these cell types after two different kinds of damage in the brain: traumatic injury (anisomorphic gliosis) and neurotoxic induced lesion (isomorphic gli... | 10.1002/glia.440080408 | 8,406,684 | D000818:Animals; D000911:Antibodies, Monoclonal; D001253:Astrocytes; D016923:Cell Death; D005625:Frontal Lobe; D005904:Glial Fibrillary Acidic Protein; D005911:Gliosis; D006624:Hippocampus; D006825:Hybridomas; D007150:Immunohistochemistry; D007276:Injections, Intraventricular; D007608:Kainic Acid; D008297:Male; D017628... | Glia | 1,993 | D000911:Antibodies, Monoclonal; D005904:Glial Fibrillary Acidic Protein; D014746:Vimentin; D007608:Kainic Acid |
Synthesis of MXene/Ag Composites for Extraordinary Long Cycle Lifetime Lithium Storage at High Rates. | A new MXene/Ag composite was synthesized by direct reduction of a AgNO3 aqueous solution in the presence of MXene (Ti3C2(OH)0.8F1.2). The as-received MXene/Ag composite can be deemed as an excellent anode material for lithium-ion batteries, exhibiting an extraordinary long cycle lifetime with a large capacity at high c... | 10.1021/acsami.6b08089 | 27,517,615 | ACS applied materials & interfaces | 2,016 | ||
Idiopathic chronic inflammatory demyelinating polyneuropathy: an epidemiological study in Italy. | AIM
The clinical and epidemiological characteristics of chronic inflammatory demyelinating polyneuropathy (CIDP) in an Italian population were assessed.
SUBJECTS AND METHODS
All subjects with a diagnosis of demyelinating neuropathy after 1990 in Piemonte and Valle d'Aosta (4,334,225 inhabitants) were considered. The ... | 10.1136/jnnp.2007.114868 | 17,494,979 | D017677:Age Distribution; D000368:Aged; D001706:Biopsy; D002391:Catchment Area, Health; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy; D008297:Male; D008875:Middle Aged; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; D01... | Journal of neurology, neurosurgery, and psychiatry | 2,007 | |
Theoretical Analysis of Stress Distribution and Cell Polarization Surrounding a Model Wound. | A growing amount of experimental evidence shows that the local elastic field acting on cells governs their spatial organization and polarity in a tissue. Interestingly, experiments on wound healing reveal a universal formation of thick actomyosin bundles around the margins of epithelial gaps. Although the forces involv... | 10.1016/j.bpj.2018.06.011 | 30,021,114 | D001696:Biomechanical Phenomena; D016764:Cell Polarity; D048430:Cell Shape; D003599:Cytoskeleton; D003609:Dactinomycin; D004848:Epithelium; D008954:Models, Biological; D013314:Stress, Mechanical; D014945:Wound Healing | Biophysical journal | 2,018 | D003609:Dactinomycin |
Infertility treatment hinders the careers of working women in Japan. | AIM
Women undergoing infertility treatment often need to balance work and fertility treatment. Therefore, we evaluated the quality of life (QOL) and impact of infertility treatment on Japanese working women and their careers.
METHODS
We conducted an online questionnaire at 18 clinics in Japan. Responses were collecte... | 10.1111/jog.14387 | 32,808,390 | D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007246:Infertility; D007564:Japan; D011788:Quality of Life; D014931:Women, Working | The journal of obstetrics and gynaecology research | 2,020 | |
A case of hepatic focal nodular hyperplasia mimicking hepatocellular carcinoma identified on gallium-68-prostate-specific membrane antigen positron emission tomography/computed tomography. | Prostate-specific membrane antigen (PSMA) is a glycosylated type-II transmembrane protein highly expressed in individual tumor cells. Lesions with PSMA expression in the liver are commonly reported as prostate cancer metastasis or hepatocellular cancer previously. This is the first case reported as hepatic focal nodula... | 10.4103/wjnm.WJNM_108_20 | 34,321,974 | World journal of nuclear medicine | 2,021 | ||
Synthesis and Optimization of Nitroxide-Based Inhibitors of Ferroptotic Cell Death in Cancer Cells and Macrophages. | JP4-039 is an alkene peptide isostere that acts as a low-micromolar inhibitor of erastin- and RSL-3-induced ferroptotic cell death in the HT-1080 cell line. In this work, we have developed new synthetic strategies that allow access to analogues of this lead structure. Enantioselective vinylogous Mannich or cross-metath... | 10.1021/acsmedchemlett.1c00561 | 35,300,093 | ACS medicinal chemistry letters | 2,022 | ||
Mindin serves as a tumour suppressor gene during colon cancer progression through MAPK/ERK signalling pathway in mice. | Mindin is important in broad spectrum of immune responses. On the other hand, we previously reported that mindin attenuated human colon cancer development by blocking angiogenesis through Egr-1-mediated regulation. However, the mice original mindin directly suppressed the syngenic colorectal cancer (CRC) growth in our ... | 10.1111/jcmm.15332 | 32,614,521 | D000818:Animals; D002453:Cell Cycle; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D003092:Colitis; D003106:Colon; D003110:Colonic Neoplasms; D004195:Disease Models, Animal; D018450:Disease Progression; D016326:Extracellular Matrix Proteins; D016147:Genes, Tumor Suppressor; D006801:Humans; D0... | Journal of cellular and molecular medicine | 2,020 | D016326:Extracellular Matrix Proteins; C000708711:Spon2 protein, mouse |
MiR-451a enhances the phagocytosis and affects both M1 and M2 polarization in macrophages. | Leukemia associated macrophages (LAMs), which are different from tumor-associated macrophages as well as classical M1 and M2 macrophages, are specifically activated by leukemic microenvironment. We have reported the heterogeneity of gene expression profiles in LAMs. However, the expression profiles of microRNA (miRNA) ... | 10.1016/j.cellimm.2021.104377 | 34,004,369 | D000818:Animals; D002454:Cell Differentiation; D002460:Cell Line; D016207:Cytokines; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D008262:Macrophage Activation; D008264:Macrophages; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs; D010587:Phagocytosis; D0... | Cellular immunology | 2,021 | D016207:Cytokines; D035683:MicroRNAs; C550758:Mirn451 microRNA, mouse |
Cimetidine induced pancytopenia. Effect on human CFU-MIX colony formation. | We describe a 26 year-old male with a pancytopenia possibly due to cimetidine. Using progenitor cell culture techniques we investigated the mechanism of this bone marrow toxicity. Our results show a cimetidine dose-dependent inhibition of normal human CFU-GM colony formation as described by Fitchen and Koeffler in 1980... | 10.1007/BF01737845 | 2,375,961 | D000328:Adult; D001853:Bone Marrow; D001854:Bone Marrow Cells; D002927:Cimetidine; D003114:Colony-Forming Units Assay; D006801:Humans; D008297:Male; D010198:Pancytopenia | Blut | 1,990 | D002927:Cimetidine |
Selective staining of immature hemopoietic cells with merocyanine 540 in flow cytometry. | Merocyanine 540 (MC540) has been reported to bind hemopoietic cells specifically. In this study, MC540 was used as a probe for the cytofluorometric discrimination of hemopoietic cells. In PHA-stimulated lymphocytes or HL-60 cells induced to differentiate with DMSO, MC540 binding was increased in actively proliferating ... | 10.1002/cyto.990090104 | 3,409,782 | D001853:Bone Marrow; D001854:Bone Marrow Cells; D002453:Cell Cycle; D002455:Cell Division; D002460:Cell Line; D002469:Cell Separation; D005434:Flow Cytometry; D006412:Hematopoietic Stem Cells; D006801:Humans; D007942:Leukemia, Experimental; D008214:Lymphocytes; D011744:Pyrimidinones | Cytometry | 1,988 | D011744:Pyrimidinones; C003954:merocyanine dye |
Effect of caffeine on leg muscle pain during cycling exercise among females. | PURPOSE
This double-blind, within-subjects experiment examined the effects of ingesting two doses of caffeine on perceptions of leg muscle pain during moderate-intensity cycling exercise among females.
METHODS
Low-caffeine-consuming college-aged females (N = 11) ingested one of two doses of caffeine (5 or 10 mg x kg(... | 10.1249/01.mss.0000193558.70995.03 | 16,540,851 | D000241:Adenosine; D000293:Adolescent; D000328:Adult; D000700:Analgesics; D001642:Bicycling; D002110:Caffeine; D004311:Double-Blind Method; D005080:Exercise Test; D005260:Female; D005845:Georgia; D006801:Humans; D007866:Leg; D010147:Pain Measurement | Medicine and science in sports and exercise | 2,006 | D000700:Analgesics; D002110:Caffeine; D000241:Adenosine |
Orbital localization error of density functional theory in shear properties of vanadium and niobium. | It is believed that the density functional theory (DFT) describes most elements with s, p, and d orbitals very well, except some materials that have strongly localized and correlated valence electrons. In this work, we find that the widely employed exchange-correlation (XC) functionals, including local-density approxim... | 10.1063/1.5136052 | 31,941,306 | The Journal of chemical physics | 2,020 | ||
IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia. | BACKGROUND
Tubulointerstitial nephritis (TIN) is typically seen in association with drug exposure and infection or in autoimmune diseases such as Sjogren's syndrome or systemic lupus erythematosis. The recently described IgG4-related systemic diseases can affect many organ systems including the kidney and typically res... | 10.5301/jn.5000298 | 24,284,523 | D000368:Aged; D001706:Biopsy; D006801:Humans; D007074:Immunoglobulin G; D007668:Kidney; D015451:Leukemia, Lymphocytic, Chronic, B-Cell; D008297:Male; D009395:Nephritis, Interstitial | Journal of nephrology | 2,013 | D007074:Immunoglobulin G |
[Sealing of airway fistulas for metallic covered z-type stents]. | BACKGROUND
Treating airway fistulas, including esophagorespiratory fistulas (ERFs), bronchopleural fistulas (BPFs), and tracheomediastinal fistulas (TMFs), is difficult. The aim of this study is to evaluate the safety and clinical efficacy of metallic covered Z-type stents (CZTS) for the treatment of airway fistulas th... | 10.3779/j.issn.1009-3419.2011.08.08 | 21,859,550 | D000368:Aged; D001999:Bronchoscopy; D004937:Esophageal Fistula; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016156:Respiratory Tract Fistula; D012189:Retrospective Studies; D015607:Stents | Zhongguo fei ai za zhi = Chinese journal of lung cancer | 2,011 | |
"All-in-one mesh" hernioplasty: A new procedure for primary inguinal hernia open repair. | BACKGROUND
We propose a new open mesh hernia repair procedure for the treatment of inguinal hernias in adults aiming to improve patients' comfort and to reduce the incidence of chronic neuralgia.
METHODS
From September 2012 to August 2015, 250 consecutive patients were treated with "all in-one" mesh hernioplasty proc... | 10.1016/j.asjsur.2017.07.003 | 28,851,612 | D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006552:Hernia, Inguinal; D059685:Herniorrhaphy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009437:Neuralgia; D011183:Postoperative Complications; D013526:Surgical Mesh; D013997:Time Fact... | Asian journal of surgery | 2,018 | |
Preparation of antiserum against rat delta6-desaturase and its use to evaluate the desaturase protein levels in rats treated with gemfibrozil, a ligand for peroxisome proliferator-activated receptor alpha. | Anti-rat delta6-desaturase serum was produced by immunizing rabbits with the 14 N-terminal amino acids (2-15) of rat delta6-desaturase. The antiserum prevented the enzymatic activity of delta6-desaturase in microsomes. Subsequently, the antiserum was used to demonstrate that gemfibrozil, a ligand for peroxisome prolife... | 10.1271/bbb.67.1177 | 12,834,305 | D000818:Animals; D000906:Antibodies; D015248:Gemfibrozil; D000960:Hypolipidemic Agents; D008024:Ligands; D008862:Microsomes, Liver; D008970:Molecular Weight; D011817:Rabbits; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear; D013230:Stearoyl-CoA Desaturase; D014157:Transcription Factors | Bioscience, biotechnology, and biochemistry | 2,003 | D000906:Antibodies; D000960:Hypolipidemic Agents; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D013230:Stearoyl-CoA Desaturase; C474452:delta 6-desaturase, rat; D015248:Gemfibrozil |
A 3D nano scale IGA for free vibration and buckling analyses of multi-directional FGM nanoshells. | This article explores a three-dimensional solid isogeometric analysis (3D-IGA) approach based on a nonlocal elasticity theory to investigate size effects on natural frequency and critical buckling load for multi-directional functionally graded (FG) nanoshells. The multi-directional FG material uses a power law rule wit... | 10.1088/1361-6528/ac32f9 | 34,695,808 | Nanotechnology | 2,021 | ||
Reaction with dioxygen of a Cu(I) complex of 1-benzyl-[3-(2'-pyridyl)]pyrazole triggers ethyl acetate hydrolysis: acetato-/pyrazolato-, dihydroxo- and diacetato-bridged Cu(II) complexes. | A copper(I) compound [(L2)Cu(MeCN)2][ClO4] (1) containing a new bidentate N-donor ligand L2, 1-benzyl-[3-(2'-pyridyl)]pyrazole, derived from the condensation of HL1 [HL1 = 3-(2-pyridyl)pyrazole] and benzyl chloride, has been synthesized. Structural analysis reveals that in the copper(I) centre is coordinated by a pyrid... | 10.1039/b512086a | 16,547,535 | D000085:Acetates; D003300:Copper; D018360:Crystallography, X-Ray; D006868:Hydrolysis; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds; D010100:Oxygen | Dalton transactions (Cambridge, England : 2003) | 2,006 | D000085:Acetates; D008024:Ligands; D009942:Organometallic Compounds; C520533:bis(acetonitrile)bis(1-benzyl-(3-(2'-pyridyl))pyrazole)copper(I); C007650:ethyl acetate; D003300:Copper; D010100:Oxygen |
Purification and characterization of phospholipase B from Kluyveromyces lactis, and cloning of phospholipase B gene. | Phospholipase B (PLB) from the yeast Kluyveromyces lactis was purified to homogeneity from culture medium. The enzyme was highly glycosylated with apparent molecular mass of 160-250 kDa, and had two pH optima, at pH 2.0 and pH 7.5. At acidic pH the enzyme hydrolyzed all phospholipid substrates tested here without metal... | 10.1271/bbb.63.83 | 10,052,126 | D000217:Acyltransferases; D000595:Amino Acid Sequence; D001483:Base Sequence; D020134:Catalytic Domain; D003001:Cloning, Molecular; D017931:DNA Primers; D004271:DNA, Fungal; D015870:Gene Expression; D005800:Genes, Fungal; D006031:Glycosylation; D006863:Hydrogen-Ion Concentration; D007716:Kluyveromyces; D008245:Lysophos... | Bioscience, biotechnology, and biochemistry | 1,999 | D017931:DNA Primers; D004271:DNA, Fungal; D000217:Acyltransferases; D008245:Lysophospholipase |
Impact of hemoglobin concentration and affinity for oxygen on tissue oxygenation: the case of hemoglobin-based oxygen carriers. | In patients undergoing exchange-transfusion with hemoglobin (Hb)-based oxygen (O₂) carriers (HBOC), native Hb coexists with newly transfused Hb. The two Hb types share the same arterial and venous PO₂, but their affinities for O₂ vary. A simple spreadsheet model is described aiming at evaluating the contribution of eac... | 10.1111/j.1525-1594.2011.01296.x | 21,848,930 | D000465:Algorithms; D001692:Biological Transport; D001802:Blood Substitutes; D005078:Exchange Transfusion, Whole Blood; D006454:Hemoglobins; D006801:Humans; D008954:Models, Biological; D010100:Oxygen | Artificial organs | 2,012 | D001802:Blood Substitutes; D006454:Hemoglobins; D010100:Oxygen |
Proteome analysis of Bordetella pertussis isolated from human macrophages. | Previous studies have shown that B. pertussis survives inside human macrophages in non-acidic compartments with characteristics of early endosomes. In order to gain new insight into the biology of B. pertussis survival in host cells, we have analyzed the adaptation of the bacterial proteome during intracellular infecti... | 26,873,878 | D001426:Bacterial Proteins; D001886:Bordetella pertussis; D045744:Cell Line, Tumor; D006801:Humans; D008264:Macrophages; D020543:Proteome | Journal of proteomics | 2,016 | D001426:Bacterial Proteins; D020543:Proteome | |
[Application of multiple MLL gene rearrangement detection techniques for children with acute mononuclear leukemia]. | OBJECTIVE
To assess the value of detecting multiple rearrangements of MLL gene in children with acute mononuclear leukemia (AML).
METHODS
Eighty six children with AML were analyzed by fluorescence in situ hybridization (FISH), chromosomal karyotyping and multiplex reverse transcription-PCR (RT-PCR).
RESULTS
Cross s... | 10.3760/cma.j.issn.1003-9406.2019.11.005 | 31,703,129 | D002648:Child; D002880:Chromosomes, Human, Pair 11; D015321:Gene Rearrangement; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute; D051788:Myeloid-Lymphoid Leukemia Protein; D014178:Translocation, Genetic | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics | 2,019 | C497422:KMT2A protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase |
Amyloidoma of the cervical spine: a case report. | This is the first published report of an amyloidoma localized to the cervical spine. Primary amyloidosis of bone is rare. Only 5 cases involving the spine have been described. We present a 74-year-old man with cervical and occipital radicular pain as the manifestations of an amyloidoma involving the 2nd cervical verteb... | 10.1227/00006123-198802000-00027 | 3,352,895 | D000368:Aged; D000686:Amyloidosis; D001706:Biopsy; D002574:Cervical Vertebrae; D006801:Humans; D008297:Male; D011859:Radiography; D013122:Spinal Diseases | Neurosurgery | 1,988 | |
Saudi guidelines for the diagnosis and management of hepatocellular carcinoma: technical review and practice guidelines. | Recognizing the significant prevalence of hepatocellular carcinoma (HCC) in Saudi Arabia, and the difficulties often faced in early and accurate diagnoses, evidence-based management, and the need for appropriate referral of HCC patients, the Saudi Association for the Study of Liver diseases and Transplantation (SASLT) ... | 10.5144/0256-4947.2012.174 | 22,366,832 | D006528:Carcinoma, Hepatocellular; D019317:Evidence-Based Medicine; D006801:Humans; D008113:Liver Neoplasms; D012529:Saudi Arabia | Annals of Saudi medicine | 2,012 | |
Differences in cortical serotonergic innervation among humans, chimpanzees, and macaque monkeys: a comparative study. | In this study, we assess the possibility that the evolution of human intellectual capacities was supported by changes in the supply of serotonin to the frontal cortex. To this end, quantitative comparative analyses were performed among humans, chimpanzees, and macaques. Immunohistochemical methods were used to visualiz... | 10.1093/cercor/bhm089 | 17,586,605 | D000328:Adult; D000818:Animals; D001369:Axons; D002540:Cerebral Cortex; D005260:Female; D000882:Haplorhini; D006801:Humans; D008251:Macaca; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways; D009474:Neurons; D002679:Pan troglodytes; D012701:Serotonin; D013045:Species Specificity | Cerebral cortex (New York, N.Y. : 1991) | 2,008 | D012701:Serotonin |
Adolescent spine patients have an increased incidence of acetabular overcoverage. | Changes in spino-pelvic alignment can lead to changes in acetabular coverage and predispose those with spinal pathologies to hip pathologies. The purpose of this study was to define the incidence of acetabular overcoverage in pediatric spine patients. Retrospective review of charts and EOS radiographs was conducted for... | 10.1093/jhps/hny004 | 29,876,129 | Journal of hip preservation surgery | 2,018 | ||
Vulnerable populations in healthcare. | PURPOSE OF REVIEW
This review is designed to update readers on recent discussions and research regarding vulnerable populations in medicine, including patients who are socioeconomically disadvantaged, queer, in prison or labeled with a stigmatizing complex medical disease.
RECENT FINDINGS
Recent studies have more clo... | 10.1097/ACO.0b013e32835e8c17 | 23,385,323 | D001675:Bioethics; D003695:Delivery of Health Care; D054242:Emigrants and Immigrants; D005260:Female; D006716:Homosexuality; D006801:Humans; D008297:Male; D010820:Physicians; D012923:Social Class; D035862:Vulnerable Populations | Current opinion in anaesthesiology | 2,013 | |
Ventricular fibrillation and the Brattleboro rat. | Despite considerable evidence from both clinical and animal experiments, the role of beta-adrenergic stimulation in the development of life-threatening cardiac arrhythmias is not well understood. Recent studies indicate that the posterior pituitary hormone, arginine vasopressin, may have a modulatory effect on cardiova... | 10.1016/s0022-2828(85)80071-7 | 4,020,885 | D000818:Animals; D001127:Arginine Vasopressin; D006339:Heart Rate; D007545:Isoproterenol; D051381:Rats; D011922:Rats, Mutant Strains; D014693:Ventricular Fibrillation | Journal of molecular and cellular cardiology | 1,985 | D001127:Arginine Vasopressin; D007545:Isoproterenol |
Microbiological Spectrum of Nosocomial ECMO Infections in a Tertiary Care Center. | INTRODUCTION
Extracorporeal membrane oxygenation (ECMO) is a life-saving treatment in cardiogenic and respiratory shock. It is prone to various complications, infection being among the most frequent. This study aims to define the prevalence and characteristics of infections in ECMO patients in a tertiary care center fo... | 10.21470/1678-9741-2020-0077 | 33,355,788 | D000328:Adult; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D012189:Retrospective Studies; D012769:Shock; D012770:Shock, Cardiogenic; D062606:Tertiary Care Centers | Brazilian journal of cardiovascular surgery | 2,021 | |
Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. | Protein kinases require strict inactivation to prevent spurious cellular signaling; overactivity can cause cancer or other diseases and necessitates selective inhibition for therapy. Rho-kinase is involved in such processes as tumor invasion, cell adhesion, smooth muscle contraction, and formation of focal adhesion fib... | 10.1016/j.str.2003.11.002 | 14,656,443 | D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D000255:Adenosine Triphosphate; D000577:Amides; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002417:Cattle; D002448:Cell Adhesion; D018360:Crystallography, X-Ray; D017868:Cyclic AMP-Dependent Protein Kinases; D004583:Electrons; D004791:Enzy... | Structure (London, England : 1993) | 2,003 | C459092:2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine; D000577:Amides; D004791:Enzyme Inhibitors; D011725:Pyridines; D011994:Recombinant Proteins; C108830:Y 27632; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D000255:Adenosine Triphosphate; D017868:Cyclic AMP-Dependent Protein Kinases; C049347... |
Correction of murine galactosialidosis by bone marrow-derived macrophages overexpressing human protective protein/cathepsin A under control of the colony-stimulating factor-1 receptor promoter. | Galactosialidosis (GS) is a human neurodegenerative disease caused by a deficiency of lysosomal protective protein/cathepsin A (PPCA). The GS mouse model resembles the severe human condition, resulting in nephropathy, ataxia, and premature death. To rescue the disease phenotype, GS mice were transplanted with bone marr... | 10.1073/pnas.95.25.14880 | 9,843,984 | D000818:Animals; D016026:Bone Marrow Transplantation; D002268:Carboxypeptidases; D043402:Cathepsin A; D064987:Cell- and Tissue-Based Therapy; D015316:Genetic Therapy; D006801:Humans; D016464:Lysosomal Storage Diseases; D008264:Macrophages; D051379:Mice; D008822:Mice, Transgenic; D011401:Promoter Regions, Genetic; D0161... | Proceedings of the National Academy of Sciences of the United States of America | 1,998 | D016186:Receptor, Macrophage Colony-Stimulating Factor; D002268:Carboxypeptidases; C468629:CTSA protein, human; D043402:Cathepsin A |
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