drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00465 | DB00586 | 886 | 1,512 | [
"DDInter1010",
"DDInter537"
] | Ketorolac | Diclofenac | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Major | 2 | [
[
[
886,
25,
1512
]
],
[
[
886,
1,
282
],
[
282,
40,
1512
]
],
[
[
886,
6,
7720
],
[
7720,
45,
1512
]
],
[
[
886,
54,
19122
],
[
19122,
... | [
[
[
"Ketorolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Diclofenac"
]
],
[
[
"Ketorolac",
"{u} (Compound) resembles {v} (Compound)",
"Nepafenac"
],
[
"Nepafenac",
"{u} (Compound) resembles {v} (Compound)",
... | Ketorolac (Compound) resembles Nepafenac (Compound) and Nepafenac (Compound) resembles Diclofenac (Compound)
Ketorolac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Diclofenac (Compound)
Ketorolac (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) and Nonsteroidal Anti... |
DB00065 | DB00290 | 581 | 329 | [
"DDInter923",
"DDInter219"
] | Infliximab | Bleomycin | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Major | 2 | [
[
[
581,
25,
329
]
],
[
[
581,
24,
58
],
[
58,
24,
329
]
],
[
[
581,
25,
372
],
[
372,
63,
329
]
],
[
[
581,
24,
1270
],
[
1270,
63,... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bleomycin"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[
"Alefacept",
... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Bleomycin
Infliximab may lead to a major life threatening interaction when taken with Clofarabine and Clofarabine may cause a... |
DB00065 | DB06228 | 581 | 792 | [
"DDInter923",
"DDInter1609"
] | Infliximab | Rivaroxaban | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
581,
24,
792
]
],
[
[
581,
25,
453
],
[
453,
40,
792
]
],
[
[
581,
24,
1412
],
[
1412,
63,
792
]
],
[
[
581,
25,
1303
],
[
1303,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Linezolid"
],
[
"Linezolid"... | Infliximab may lead to a major life threatening interaction when taken with Linezolid and Linezolid (Compound) resembles Rivaroxaban (Compound)
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol and Calaspargase pegol may cause a moderate interaction that could... |
DB00549 | DB00619 | 522 | 1,419 | [
"DDInter1955",
"DDInter909"
] | Zafirlukast | Imatinib | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
522,
24,
1419
]
],
[
[
522,
6,
6017
],
[
6017,
45,
1419
]
],
[
[
522,
21,
28762
],
[
28762,
60,
1419
]
],
[
[
522,
23,
907
],
[
907,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Zafirlukast",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",... | Zafirlukast (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Imatinib (Compound)
Zafirlukast (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Imatinib (Compound)
Zafirlukast may cause a minor interaction that can limit clinical effects when taken with Doravirine and Doravirin... |
DB01051 | DB09268 | 1,153 | 1,662 | [
"DDInter1317",
"DDInter1464"
] | Novobiocin | Picosulfuric acid | Novobiocin is an antibiotic compound derived from _Streptomyces niveus_. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) Novobiocin sodium, a salt form of novobiocin,... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1153,
24,
1662
]
],
[
[
1153,
6,
10083
],
[
10083,
45,
1220
],
[
1220,
24,
1662
]
],
[
[
1153,
6,
17404
],
[
17404,
45,
1069
],
[
1069,
... | [
[
[
"Novobiocin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Novobiocin",
"{u} (Compound) binds {v} (Gene)",
"ABCB11"
],
[
"ABCB11",
"{u} (Gene) is bound by {v} (Comp... | Novobiocin (Compound) binds ABCB11 (Gene) and ABCB11 (Gene) is bound by Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Novobiocin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Vandetanib (Compound) and Vandetanib ... |
DB08896 | DB12364 | 292 | 1,421 | [
"DDInter1576",
"DDInter200"
] | Regorafenib | Betrixaban | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
292,
25,
1421
]
],
[
[
292,
63,
1091
],
[
1091,
24,
1421
]
],
[
[
292,
24,
1017
],
[
1017,
24,
1421
]
],
[
[
292,
25,
1339
],
[
1339,
... | [
[
[
"Regorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Regorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
],
[
"Amprenav... | Regorafenib may cause a moderate interaction that could exacerbate diseases when taken with Amprenavir and Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Regorafenib may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorl... |
DB08826 | DB11255 | 1,292 | 1,371 | [
"DDInter489",
"DDInter374"
] | Deferiprone | Chromium picolinate | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. Chromium ions are show... | Moderate | 1 | [
[
[
1292,
24,
1371
]
],
[
[
1292,
63,
72
],
[
72,
24,
1371
]
],
[
[
1292,
21,
29024
],
[
29024,
60,
245
],
[
245,
24,
1371
]
],
[
[
1292,
... | [
[
[
"Deferiprone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chromium picolinate"
]
],
[
[
"Deferiprone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eltrombopag"
... | Deferiprone may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag and Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Chromium picolinate
Deferiprone (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by... |
DB00331 | DB09129 | 1,645 | 625 | [
"DDInter1164",
"DDInter373"
] | Metformin | Chromic chloride | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Chromic chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN). | Moderate | 1 | [
[
[
1645,
24,
625
]
],
[
[
1645,
62,
1647
],
[
1647,
24,
625
]
],
[
[
1645,
24,
473
],
[
473,
24,
625
]
],
[
[
1645,
24,
1296
],
[
1296,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chromic chloride"
]
],
[
[
"Metformin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acarbose"
],
[
... | Metformin may cause a minor interaction that can limit clinical effects when taken with Acarbose and Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Chromic chloride
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repagli... |
DB00801 | DB01390 | 1,563 | 1,117 | [
"DDInter850",
"DDInter1683"
] | Halazepam | Sodium bicarbonate | Halazepam is a _benzodiazepine_ derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects.[A1212, A178114] It has been shown to be less toxic than chlordiazepoxide or diazepam. This drug is no longer marketed in the United States, and was withdrawn by _Schering_, its manufacturer, in 2009... | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Minor | 0 | [
[
[
1563,
23,
1117
]
],
[
[
1563,
40,
1119
],
[
1119,
23,
1117
]
],
[
[
1563,
1,
902
],
[
902,
23,
1117
]
],
[
[
1563,
1,
481
],
[
481,
... | [
[
[
"Halazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Halazepam",
"{u} (Compound) resembles {v} (Compound)",
"Chlordiazepoxide"
],
[
"Chlordiazepoxide",
"{u} may... | Halazepam (Compound) resembles Chlordiazepoxide (Compound) and Chlordiazepoxide may cause a minor interaction that can limit clinical effects when taken with Sodium bicarbonate
Halazepam (Compound) resembles Clobazam (Compound) and Clobazam may cause a minor interaction that can limit clinical effects when taken with S... |
DB00741 | DB00867 | 167 | 1,052 | [
"DDInter885",
"DDInter1606"
] | Hydrocortisone | Ritodrine | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Adrenergic beta-agonist used to control premature labor. | Minor | 0 | [
[
[
167,
23,
1052
]
],
[
[
167,
63,
1523
],
[
1523,
40,
1052
]
],
[
[
167,
1,
1351
],
[
1351,
23,
1052
]
],
[
[
167,
40,
870
],
[
870,
... | [
[
[
"Hydrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ritodrine"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
],
... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Ritodrine (Compound)
Hydrocortisone (Compound) resembles Flunisolide (Compound) and Flunisolide may cause a minor interaction that can limit clinical effects when taken with Ritodr... |
DB00382 | DB12141 | 62 | 971 | [
"DDInter1734",
"DDInter817"
] | Tacrine | Gilteritinib | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
62,
24,
971
]
],
[
[
62,
24,
112
],
[
112,
23,
971
]
],
[
[
62,
24,
485
],
[
485,
24,
971
]
],
[
[
62,
24,
823
],
[
823,
63,
... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Penta... |
DB00005 | DB00008 | 1,057 | 491 | [
"DDInter687",
"DDInter1407"
] | Etanercept | Peginterferon alfa-2a | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Moderate | 1 | [
[
[
1057,
24,
491
]
],
[
[
1057,
25,
450
],
[
450,
62,
491
]
],
[
[
1057,
24,
576
],
[
576,
62,
491
]
],
[
[
1057,
24,
522
],
[
522,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2a"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cyclophosphamide"
],
[
... | Etanercept may lead to a major life threatening interaction when taken with Cyclophosphamide and Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Peginterferon alfa-2a
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Methadone and M... |
DB00831 | DB01233 | 1,178 | 1,311 | [
"DDInter1866",
"DDInter1197"
] | Trifluoperazine | Metoclopramide | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Major | 2 | [
[
[
1178,
25,
1311
]
],
[
[
1178,
24,
1151
],
[
1151,
40,
1311
]
],
[
[
1178,
64,
1425
],
[
1425,
40,
1311
]
],
[
[
1178,
6,
2250
],
[
225... | [
[
[
"Trifluoperazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
],
[
... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Sunitinib (Compound) resembles Metoclopramide (Compound)
Trifluoperazine may lead to a major life threatening interaction when taken with Cisapride and Cisapride (Compound) resembles Metoclopramide (Compound)
T... |
DB00196 | DB11057 | 600 | 720 | [
"DDInter743",
"DDInter1223"
] | Fluconazole | Mineral oil | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
600,
24,
720
]
],
[
[
600,
25,
927
],
[
927,
63,
720
]
],
[
[
600,
24,
175
],
[
175,
24,
720
]
],
[
[
600,
25,
1069
],
[
1069,
2... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
],
[
"Encora... | Fluconazole may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone... |
DB11943 | DB12141 | 255 | 971 | [
"DDInter495",
"DDInter817"
] | Delafloxacin | Gilteritinib | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
255,
24,
971
]
],
[
[
255,
24,
466
],
[
466,
62,
971
]
],
[
[
255,
63,
1645
],
[
1645,
24,
971
]
],
[
[
255,
62,
51
],
[
51,
24,... | [
[
[
"Delafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Delafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Delafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Delafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Metformin and... |
DB00759 | DB11093 | 1,620 | 636 | [
"DDInter1783",
"DDInter273"
] | Tetracycline | Calcium citrate | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
1620,
24,
636
]
],
[
[
1620,
1,
1572
],
[
1572,
24,
636
]
],
[
[
1620,
23,
504
],
[
504,
24,
636
]
],
[
[
1620,
24,
1482
],
[
1482,
... | [
[
[
"Tetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Tetracycline",
"{u} (Compound) resembles {v} (Compound)",
"Demeclocycline"
],
[
"Demeclocycline",
"{u} ma... | Tetracycline (Compound) resembles Demeclocycline (Compound) and Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Tetracycline may cause a minor interaction that can limit clinical effects when taken with Hydrochlorothiazide and Hydrochlorothiazide may cause ... |
DB00432 | DB01097 | 1,083 | 1,377 | [
"DDInter1868",
"DDInter1033"
] | Trifluridine | Leflunomide | Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
1083,
25,
1377
]
],
[
[
1083,
21,
28722
],
[
28722,
60,
1377
]
],
[
[
1083,
63,
1461
],
[
1461,
23,
1377
]
],
[
[
1083,
24,
949
],
[
9... | [
[
[
"Trifluridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Trifluridine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v} (Compo... | Trifluridine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Leflunomide (Compound)
Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Leflunomide
... |
DB00486 | DB00489 | 1,614 | 17 | [
"DDInter1253",
"DDInter1704"
] | Nabilone | Sotalol | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Moderate | 1 | [
[
[
1614,
24,
17
]
],
[
[
1614,
63,
88
],
[
88,
40,
17
]
],
[
[
1614,
21,
29648
],
[
29648,
60,
17
]
],
[
[
1614,
63,
999
],
[
999,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sotalol"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoprolol"
],
[
"Me... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Sotalol (Compound)
Nabilone (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Sotalol (Compound)
Nabilone may cause a moderate interaction th... |
DB06616 | DB09080 | 594 | 144 | [
"DDInter224",
"DDInter1331"
] | Bosutinib | Olodaterol | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
594,
24,
144
]
],
[
[
594,
62,
1247
],
[
1247,
23,
144
]
],
[
[
594,
63,
956
],
[
956,
24,
144
]
],
[
[
594,
25,
1011
],
[
1011,
... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Bosutinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Bosutinib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Olodaterol
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and... |
DB00574 | DB08907 | 121 | 1,344 | [
"DDInter717",
"DDInter280"
] | Fenfluramine | Canagliflozin | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
121,
24,
1344
]
],
[
[
121,
24,
549
],
[
549,
1,
1344
]
],
[
[
121,
24,
1148
],
[
1148,
24,
1344
]
],
[
[
121,
63,
176
],
[
176,
... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate inter... |
DB00661 | DB08899 | 122 | 129 | [
"DDInter1928",
"DDInter649"
] | Verapamil | Enzalutamide | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
122,
24,
129
]
],
[
[
122,
6,
8374
],
[
8374,
45,
129
]
],
[
[
122,
21,
28703
],
[
28703,
60,
129
]
],
[
[
122,
62,
1512
],
[
1512,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Verapamil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Verapamil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Verapamil (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Verapamil may cause a minor interaction that can limit clinical effects when taken with Diclofenac and Diclofe... |
DB00312 | DB09073 | 1,023 | 951 | [
"DDInter1423",
"DDInter1379"
] | Pentobarbital | Palbociclib | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1023,
24,
951
]
],
[
[
1023,
24,
1476
],
[
1476,
63,
951
]
],
[
[
1023,
24,
578
],
[
578,
24,
951
]
],
[
[
1023,
1,
288
],
[
288,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
... | Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and... |
DB01359 | DB08907 | 729 | 1,344 | [
"DDInter1417",
"DDInter280"
] | Penbutolol | Canagliflozin | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
729,
24,
1344
]
],
[
[
729,
24,
549
],
[
549,
1,
1344
]
],
[
[
729,
6,
6943
],
[
6943,
45,
1344
]
],
[
[
729,
21,
28714
],
[
28714,
... | [
[
[
"Penbutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Penbutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Penbutolol may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Penbutolol (Compound) binds ORM1 (Gene) and ORM1 (Gene) is bound by Canagliflozin (Compound)
Penbutolol (Compound) causes Asthenia (Side Effect) and As... |
DB00495 | DB00987 | 139 | 1,224 | [
"DDInter1961",
"DDInter460"
] | Zidovudine | Cytarabine | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Moderate | 1 | [
[
[
139,
24,
1224
]
],
[
[
139,
24,
1426
],
[
1426,
1,
1224
]
],
[
[
139,
6,
8803
],
[
8803,
45,
1224
]
],
[
[
139,
7,
9681
],
[
9681,
... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cytarabine"
]
],
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azacitidine"
],
[
... | Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Azacitidine and Azacitidine (Compound) resembles Cytarabine (Compound)
Zidovudine (Compound) binds SLC22A2 (Gene) and SLC22A2 (Gene) is bound by Cytarabine (Compound)
Zidovudine (Compound) upregulates THAP11 (Gene) and THAP11 (Ge... |
DB06186 | DB11989 | 1,439 | 1,434 | [
"DDInter969",
"DDInter183"
] | Ipilimumab | Benznidazole | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease. | Moderate | 1 | [
[
[
1439,
24,
1434
]
],
[
[
1439,
24,
788
],
[
788,
24,
1434
]
],
[
[
1439,
63,
309
],
[
309,
24,
1434
]
],
[
[
1439,
24,
148
],
[
148,
... | [
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benznidazole"
]
],
[
[
"Ipilimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
... | Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Ipilimumab may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and... |
DB00331 | DB14276 | 1,645 | 1,631 | [
"DDInter1164",
"DDInter1892"
] | Metformin | Turmeric | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Moderate | 1 | [
[
[
1645,
24,
1631
]
],
[
[
1645,
24,
126
],
[
126,
23,
1631
]
],
[
[
1645,
24,
473
],
[
473,
24,
1631
]
],
[
[
1645,
62,
1647
],
[
1647,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Turmeric"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
[
"W... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Turmeric
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide may... |
DB06228 | DB11767 | 792 | 1,583 | [
"DDInter1609",
"DDInter1643"
] | Rivaroxaban | Sarilumab | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
792,
24,
1583
]
],
[
[
792,
63,
1461
],
[
1461,
23,
1583
]
],
[
[
792,
64,
362
],
[
362,
24,
1583
]
],
[
[
792,
63,
33
],
[
33,
... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Sarilumab
Rivaroxaban may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin may cause a mod... |
DB00207 | DB06723 | 1,570 | 115 | [
"DDInter157",
"DDInter58"
] | Azithromycin | Aluminum hydroxide | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
1570,
24,
115
]
],
[
[
1570,
21,
28872
],
[
28872,
60,
115
]
],
[
[
1570,
24,
355
],
[
355,
23,
115
]
],
[
[
1570,
24,
1213
],
[
1213,... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Azithromycin",
"{u} (Compound) causes {v} (Side Effect)",
"Extravasation"
],
[
"Extravasation",
"{u} (... | Azithromycin (Compound) causes Extravasation (Side Effect) and Extravasation (Side Effect) is caused by Aluminum hydroxide (Compound)
Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Lactulose and Lactulose may cause a minor interaction that can limit clinical effects when ta... |
DB01224 | DB08824 | 623 | 591 | [
"DDInter1553",
"DDInter959"
] | Quetiapine | Ioflupane I-123 | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
623,
24,
591
]
],
[
[
623,
21,
29305
],
[
29305,
60,
591
]
],
[
[
623,
40,
1630
],
[
1630,
24,
591
]
],
[
[
623,
63,
401
],
[
401,
... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Quetiapine",
"{u} (Compound) causes {v} (Side Effect)",
"Dysgeusia"
],
[
"Dysgeusia",
"{u} (Side Effect) is... | Quetiapine (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Ioflupane I-123 (Compound)
Quetiapine (Compound) resembles Perphenazine (Compound) and Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Quetiapine may cause a moderat... |
DB01285 | DB14711 | 708 | 779 | [
"DDInter445",
"DDInter1680"
] | Corticotropin | Smallpox (Vaccinia) Vaccine, Live | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
708,
25,
779
]
],
[
[
708,
64,
1064
],
[
1064,
25,
779
]
],
[
[
708,
25,
1259
],
[
1259,
25,
779
]
],
[
[
708,
24,
270
],
[
270,
... | [
[
[
"Corticotropin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Corticotropin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
... | Corticotropin may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Corticotropin may lead to a major life threatening interaction when taken with Baricitinib and Baricitinib may lead ... |
DB09237 | DB12010 | 1,586 | 214 | [
"DDInter1045",
"DDInter785"
] | Levamlodipine | Fostamatinib | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1586,
24,
214
]
],
[
[
1586,
63,
723
],
[
723,
24,
214
]
],
[
[
1586,
64,
467
],
[
467,
24,
214
]
],
[
[
1586,
24,
1017
],
[
1017,
... | [
[
[
"Levamlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Levamlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
... | Levamlodipine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Levamlodipine may lead to a major life threatening interaction when taken with Simvastatin and Simvastatin ... |
DB00350 | DB00687 | 1,214 | 870 | [
"DDInter1226",
"DDInter747"
] | Minoxidil | Fludrocortisone | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Moderate | 1 | [
[
[
1214,
24,
870
]
],
[
[
1214,
24,
1220
],
[
1220,
40,
870
]
],
[
[
1214,
24,
961
],
[
961,
63,
870
]
],
[
[
1214,
24,
536
],
[
536,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Licorice and Licorice may cause a moderate interaction that ... |
DB00531 | DB00570 | 450 | 147 | [
"DDInter456",
"DDInter1936"
] | Cyclophosphamide | Vinblastine | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Moderate | 1 | [
[
[
450,
24,
147
]
],
[
[
450,
63,
134
],
[
134,
24,
147
]
],
[
[
450,
6,
8374
],
[
8374,
45,
147
]
],
[
[
450,
18,
4729
],
[
4729,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
... | Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine
Cyclophosphamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vinblastine (Compound)
Cy... |
DB01174 | DB06335 | 697 | 761 | [
"DDInter1442",
"DDInter1646"
] | Phenobarbital | Saxagliptin | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
697,
24,
761
]
],
[
[
697,
6,
10417
],
[
10417,
45,
761
]
],
[
[
697,
21,
28722
],
[
28722,
60,
761
]
],
[
[
697,
25,
1491
],
[
1491,
... | [
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Phenobarbital",
"{u} (Compound) binds {v} (Gene)",
"ABCC1"
],
[
"ABCC1",
"{u} (Gene) is bound by {v} (Compou... | Phenobarbital (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Saxagliptin (Compound)
Phenobarbital (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Phenobarbital may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may... |
DB01254 | DB11986 | 1,213 | 484 | [
"DDInter484",
"DDInter648"
] | Dasatinib | Entrectinib | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1213,
24,
484
]
],
[
[
1213,
62,
1247
],
[
1247,
23,
484
]
],
[
[
1213,
23,
271
],
[
271,
23,
484
]
],
[
[
1213,
63,
222
],
[
222,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Dasatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[... | Dasatinib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Dasatinib may cause a minor interaction that can limit clinical effects when taken with Mirabegron and M... |
DB00762 | DB11652 | 613 | 1,155 | [
"DDInter973",
"DDInter1891"
] | Irinotecan | Tucatinib | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Major | 2 | [
[
[
613,
25,
1155
]
],
[
[
613,
63,
1101
],
[
1101,
23,
1155
]
],
[
[
613,
25,
609
],
[
609,
24,
1155
]
],
[
[
613,
63,
522
],
[
522,
... | [
[
[
"Irinotecan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tucatinib"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarotene"... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Tucatinib
Irinotecan may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may c... |
DB00674 | DB09054 | 1,516 | 384 | [
"DDInter802",
"DDInter905"
] | Galantamine | Idelalisib | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1516,
24,
384
]
],
[
[
1516,
24,
1618
],
[
1618,
24,
384
]
],
[
[
1516,
63,
1555
],
[
1555,
24,
384
]
],
[
[
1516,
24,
1228
],
[
1228,... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabozantinib"
],
... | Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and... |
DB00352 | DB11767 | 482 | 1,583 | [
"DDInter1814",
"DDInter1643"
] | Tioguanine | Sarilumab | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
482,
24,
1583
]
],
[
[
482,
63,
1461
],
[
1461,
23,
1583
]
],
[
[
482,
24,
267
],
[
267,
24,
1583
]
],
[
[
482,
63,
362
],
[
362,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Sarilumab
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone ... |
DB00678 | DB01276 | 240 | 123 | [
"DDInter1095",
"DDInter706"
] | Losartan | Exenatide | Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough simila... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
240,
24,
123
]
],
[
[
240,
24,
708
],
[
708,
63,
123
]
],
[
[
240,
63,
1573
],
[
1573,
24,
123
]
],
[
[
240,
40,
217
],
[
217,
2... | [
[
[
"Losartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Losartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
],
[
... | Losartan may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Losartan may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Predn... |
DB00279 | DB11827 | 1,152 | 433 | [
"DDInter1074",
"DDInter669"
] | Liothyronine | Ertugliflozin | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1152,
24,
433
]
],
[
[
1152,
23,
1121
],
[
1121,
24,
433
]
],
[
[
1152,
24,
959
],
[
959,
24,
433
]
],
[
[
1152,
63,
362
],
[
362,
... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Liothyronine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bisoprolol"
],
... | Liothyronine may cause a minor interaction that can limit clinical effects when taken with Bisoprolol and Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Gl... |
DB00630 | DB09481 | 1,485 | 460 | [
"DDInter42",
"DDInter1113"
] | Alendronic acid | Magnesium carbonate | Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
1485,
24,
460
]
],
[
[
1485,
62,
752
],
[
752,
23,
460
]
],
[
[
1485,
23,
1559
],
[
1559,
23,
460
]
],
[
[
1485,
24,
853
],
[
853,
... | [
[
[
"Alendronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Alendronic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine... | Alendronic acid may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Alendronic acid may cause a minor interaction that can limit clinical effects when taken with Famotidi... |
DB01064 | DB01261 | 1,148 | 170 | [
"DDInter987",
"DDInter1679"
] | Isoprenaline | Sitagliptin | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1148,
24,
170
]
],
[
[
1148,
21,
28921
],
[
28921,
60,
170
]
],
[
[
1148,
24,
52
],
[
52,
62,
170
]
],
[
[
1148,
63,
1252
],
[
1252,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Isoprenaline",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is... | Isoprenaline (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Sitagliptin (Compound)
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a minor interaction that can limit clinical effects when taken with Si... |
DB00023 | DB09061 | 305 | 1,627 | [
"DDInter127",
"DDInter284"
] | Asparaginase Escherichia coli | Cannabidiol | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
305,
24,
1627
]
],
[
[
305,
24,
609
],
[
609,
23,
1627
]
],
[
[
305,
24,
888
],
[
888,
24,
1627
]
],
[
[
305,
24,
1613
],
[
1613,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate d... |
DB00776 | DB00907 | 1,335 | 290 | [
"DDInter1360",
"DDInter427"
] | Oxcarbazepine | Cocaine (topical) | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Moderate | 1 | [
[
[
1335,
24,
290
]
],
[
[
1335,
6,
8374
],
[
8374,
45,
290
]
],
[
[
1335,
21,
28741
],
[
28741,
60,
290
]
],
[
[
1335,
24,
629
],
[
629,
... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cocaine"
]
],
[
[
"Oxcarbazepine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Cocaine
Oxcarbazepine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cocaine (Compound)
Oxcarbazepine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Cocaine (Compound)
Oxcarbaz... |
DB00295 | DB13909 | 475 | 1,277 | [
"DDInter1244",
"DDInter214"
] | Morphine | Bismuth subgallate | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Bismuth subgallate is a yellow colored substance that presents as an odorless powder that undergoes discoloration when exposed to sunlight. It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed. Possessing protective effects on the gastric mucosa, strong astringent effects, and not as yet... | Moderate | 1 | [
[
[
475,
24,
1277
]
],
[
[
475,
24,
407
],
[
407,
24,
1277
]
],
[
[
475,
6,
8374
],
[
8374,
45,
964
],
[
964,
24,
1277
]
],
[
[
475,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bismuth subgallate"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Bismuth subgallate
Morphine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Doxycycline (Compound) and Doxycycline may cau... |
DB00637 | DB01267 | 1,557 | 519 | [
"DDInter128",
"DDInter1381"
] | Astemizole | Paliperidone | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
1557,
24,
519
]
],
[
[
1557,
24,
1664
],
[
1664,
1,
519
]
],
[
[
1557,
25,
924
],
[
924,
1,
519
]
],
[
[
1557,
6,
7524
],
[
7524,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[... | Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Astemizole may lead to a major life threatening interaction when taken with Iloperidone and Iloperidone (Compound) resembles Paliperidone (Compound)
Astemiz... |
DB06603 | DB08908 | 39 | 713 | [
"DDInter1387",
"DDInter564"
] | Panobinostat | Dimethyl fumarate | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
39,
24,
713
]
],
[
[
39,
25,
996
],
[
996,
24,
713
]
],
[
[
39,
63,
4
],
[
4,
24,
713
]
],
[
[
39,
64,
1250
],
[
1250,
24,
... | [
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
],
[
... | Panobinostat may lead to a major life threatening interaction when taken with Bedaquiline and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccina... |
DB00404 | DB11834 | 523 | 1,303 | [
"DDInter54",
"DDInter849"
] | Alprazolam | Guselkumab | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Moderate | 1 | [
[
[
523,
24,
1303
]
],
[
[
523,
1,
902
],
[
902,
24,
1303
]
],
[
[
523,
63,
58
],
[
58,
24,
1303
]
],
[
[
523,
24,
259
],
[
259,
24,... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guselkumab"
]
],
[
[
"Alprazolam",
"{u} (Compound) resembles {v} (Compound)",
"Clobazam"
],
[
"Clobazam",
"{u} may cause a moderate in... | Alprazolam (Compound) resembles Clobazam (Compound) and Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Guselkumab
Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exace... |
DB00222 | DB00334 | 245 | 867 | [
"DDInter825",
"DDInter1326"
] | Glimepiride | Olanzapine | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Moderate | 1 | [
[
[
245,
24,
867
]
],
[
[
245,
24,
695
],
[
695,
40,
867
]
],
[
[
245,
6,
6017
],
[
6017,
45,
867
]
],
[
[
245,
24,
1616
],
[
1616,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olanzapine"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Olanzapine (Compound)
Glimepiride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Olanzapine (Compound)
Glimepiride may cause a moderate interaction that could exacerbate... |
DB06372 | DB06605 | 259 | 1,409 | [
"DDInter1594",
"DDInter108"
] | Rilonacept | Apixaban | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Moderate | 1 | [
[
[
259,
24,
1409
]
],
[
[
259,
63,
58
],
[
58,
24,
1409
]
],
[
[
259,
64,
1057
],
[
1057,
24,
1409
]
],
[
[
259,
24,
351
],
[
351,
... | [
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
]
],
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[
... | Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Apixaban
Rilonacept may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a mo... |
DB00999 | DB01168 | 504 | 1,053 | [
"DDInter883",
"DDInter1526"
] | Hydrochlorothiazide | Procarbazine | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
504,
24,
1053
]
],
[
[
504,
24,
848
],
[
848,
40,
1053
]
],
[
[
504,
18,
4930
],
[
4930,
57,
1053
]
],
[
[
504,
21,
28762
],
[
28762,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprof... | Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Procarbazine (Compound)
Hydrochlorothiazide (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Procarbazine (Compound)
Hydrochlorothiazide (Compound) cause... |
DB01618 | DB06691 | 776 | 849 | [
"DDInter1239",
"DDInter1155"
] | Molindone | Mepyramine | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
776,
24,
849
]
],
[
[
776,
63,
1594
],
[
1594,
24,
849
]
],
[
[
776,
24,
1116
],
[
1116,
63,
849
]
],
[
[
776,
24,
830
],
[
830,
... | [
[
[
"Molindone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Molindone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Molindone may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Molindone may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium and Umecli... |
DB00530 | DB04908 | 1,195 | 1,671 | [
"DDInter667",
"DDInter741"
] | Erlotinib | Flibanserin | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
1195,
24,
1671
]
],
[
[
1195,
24,
741
],
[
741,
63,
1671
]
],
[
[
1195,
63,
752
],
[
752,
24,
1671
]
],
[
[
1195,
64,
1215
],
[
1215,
... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
],
[
... | Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin
Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetid... |
DB00500 | DB00585 | 24 | 1,127 | [
"DDInter1831",
"DDInter1309"
] | Tolmetin | Nizatidine | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. | Minor | 0 | [
[
[
24,
23,
1127
]
],
[
[
24,
23,
1194
],
[
1194,
40,
1127
]
],
[
[
24,
6,
7720
],
[
7720,
46,
1127
]
],
[
[
24,
21,
28898
],
[
28898,
... | [
[
[
"Tolmetin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nizatidine"
]
],
[
[
"Tolmetin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ranitidine"
],
[
"Ran... | Tolmetin may cause a minor interaction that can limit clinical effects when taken with Ranitidine and Ranitidine (Compound) resembles Nizatidine (Compound)
Tolmetin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Nizatidine (Compound)
Tolmetin (Compound) causes Constipation (Side Effect) and Constipati... |
DB00872 | DB01110 | 1,080 | 86 | [
"DDInter438",
"DDInter1209"
] | Conivaptan | Miconazole | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
1080,
24,
86
]
],
[
[
1080,
6,
8374
],
[
8374,
45,
86
]
],
[
[
1080,
21,
29122
],
[
29122,
60,
86
]
],
[
[
1080,
24,
222
],
[
222,
... | [
[
[
"Conivaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Conivaptan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Conivaptan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Miconazole (Compound)
Conivaptan (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Miconazole (Compound)
Conivaptan may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00791 | DB12615 | 132 | 1,381 | [
"DDInter1902",
"DDInter1482"
] | Uracil mustard | Plazomicin | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from . The structure of plazomicin was established via appending hydroxylaminobutyric acid to at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglyco... | Moderate | 1 | [
[
[
132,
24,
1381
]
],
[
[
132,
63,
1287
],
[
1287,
24,
1381
]
],
[
[
132,
25,
1510
],
[
1510,
62,
608
],
[
608,
23,
1381
]
],
[
[
132,
... | [
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Plazomicin"
]
],
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphotericin B"
... | Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Amphotericin B and Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Plazomicin
Uracil mustard may lead to a major life threatening interaction when taken with Teriflunomide and Te... |
DB01060 | DB01357 | 319 | 890 | [
"DDInter83",
"DDInter1160"
] | Amoxicillin | Mestranol | Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to [penicillin] and [ampicillin], but leads to higher serum concentrations than ampicillin. Amoxicillin was granted FDA approval on 18 January 1974. | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Moderate | 1 | [
[
[
319,
24,
890
]
],
[
[
319,
63,
1438
],
[
1438,
1,
890
]
],
[
[
319,
63,
1572
],
[
1572,
24,
890
]
],
[
[
319,
63,
1096
],
[
1096,
... | [
[
[
"Amoxicillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
]
],
[
[
"Amoxicillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
[
... | Amoxicillin may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol (Compound) resembles Mestranol (Compound)
Amoxicillin may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline may cause a moderate interaction tha... |
DB00046 | DB00603 | 1,179 | 303 | [
"DDInter940",
"DDInter1137"
] | Insulin lispro | Medroxyprogesterone acetate | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Moderate | 1 | [
[
[
1179,
24,
303
]
],
[
[
1179,
24,
167
],
[
167,
1,
303
]
],
[
[
1179,
24,
1561
],
[
1561,
40,
303
]
],
[
[
1179,
24,
215
],
[
215,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Medroxyprogesterone acetate"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hy... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Medroxyprogesterone acetate (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Testosterone and Testosterone (Compo... |
DB00201 | DB08881 | 1,684 | 868 | [
"DDInter263",
"DDInter1925"
] | Caffeine | Vemurafenib | Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but ... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
1684,
24,
868
]
],
[
[
1684,
6,
8374
],
[
8374,
45,
868
]
],
[
[
1684,
7,
3771
],
[
3771,
57,
868
]
],
[
[
1684,
18,
15501
],
[
15501,... | [
[
[
"Caffeine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Caffeine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Caffeine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Caffeine (Compound) upregulates SUV39H1 (Gene) and SUV39H1 (Gene) is downregulated by Vemurafenib (Compound)
Caffeine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Vemurafenib (Compound)
Caffeine ... |
DB00211 | DB00938 | 1,290 | 455 | [
"DDInter1213",
"DDInter1635"
] | Midodrine | Salmeterol | An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension. | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
1290,
24,
455
]
],
[
[
1290,
24,
688
],
[
688,
63,
455
]
],
[
[
1290,
21,
29024
],
[
29024,
60,
455
]
],
[
[
1290,
24,
870
],
[
870,
... | [
[
[
"Midodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Midodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[
... | Midodrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Midodrine (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Salmeterol (Co... |
DB00286 | DB01124 | 380 | 1,411 | [
"DDInter439",
"DDInter1828"
] | Conjugated estrogens | Tolbutamide | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
380,
24,
1411
]
],
[
[
380,
24,
959
],
[
959,
40,
1411
]
],
[
[
380,
63,
245
],
[
245,
40,
1411
]
],
[
[
380,
6,
10612
],
[
10612,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipiz... | Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles T... |
DB00281 | DB00358 | 608 | 1,010 | [
"DDInter1066",
"DDInter1140"
] | Lidocaine | Mefloquine | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Moderate | 1 | [
[
[
608,
24,
1010
]
],
[
[
608,
6,
8374
],
[
8374,
45,
1010
]
],
[
[
608,
18,
2201
],
[
2201,
57,
1010
]
],
[
[
608,
21,
28789
],
[
28789,... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
]
],
[
[
"Lidocaine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Lidocaine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Mefloquine (Compound)
Lidocaine (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) is downregulated by Mefloquine (Compound)
Lidocaine (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by... |
DB00214 | DB11110 | 1,028 | 603 | [
"DDInter1836",
"DDInter1115"
] | Torasemide | Magnesium citrate | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1028,
24,
603
]
],
[
[
1028,
25,
57
],
[
57,
24,
603
]
],
[
[
1028,
24,
870
],
[
870,
24,
603
]
],
[
[
1028,
23,
1545
],
[
1545,
... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Torasemide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Torasemide may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone a... |
DB00284 | DB00396 | 1,647 | 989 | [
"DDInter11",
"DDInter1529"
] | Acarbose | Progesterone | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss . Progesterone is used in va... | Moderate | 1 | [
[
[
1647,
24,
989
]
],
[
[
1647,
24,
891
],
[
891,
40,
989
]
],
[
[
1647,
24,
167
],
[
167,
1,
989
]
],
[
[
1647,
21,
29134
],
[
29134,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Progesterone"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone (Compound) resembles Progesterone (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Progesterone... |
DB01138 | DB08896 | 804 | 292 | [
"DDInter1726",
"DDInter1576"
] | Sulfinpyrazone | Regorafenib | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Major | 2 | [
[
[
804,
25,
292
]
],
[
[
804,
63,
79
],
[
79,
1,
292
]
],
[
[
804,
6,
6017
],
[
6017,
45,
292
]
],
[
[
804,
24,
1135
],
[
1135,
62,... | [
[
[
"Sulfinpyrazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Regorafenib"
]
],
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
[
"So... | Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) resembles Regorafenib (Compound)
Sulfinpyrazone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Regorafenib (Compound)
Sulfinpyrazone may cause a moderate interaction that could... |
DB00557 | DB00675 | 252 | 888 | [
"DDInter895",
"DDInter1744"
] | Hydroxyzine | Tamoxifen | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Moderate | 1 | [
[
[
252,
24,
888
]
],
[
[
252,
24,
832
],
[
832,
40,
888
]
],
[
[
252,
63,
1594
],
[
1594,
40,
888
]
],
[
[
252,
24,
543
],
[
543,
6... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
]
],
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
],
... | Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine (Compound) resembles Tamoxifen (Compound)
Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine (Compound) resembles Tamoxifen (Co... |
DB00816 | DB13139 | 1,674 | 1,032 | [
"DDInter1346",
"DDInter1063"
] | Orciprenaline | Levosalbutamol | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
1674,
24,
1032
]
],
[
[
1674,
62,
218
],
[
218,
23,
1032
]
],
[
[
1674,
23,
1486
],
[
1486,
23,
1032
]
],
[
[
1674,
25,
1618
],
[
1618... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Orciprenaline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Beclomethasone dipr... | Orciprenaline may cause a minor interaction that can limit clinical effects when taken with Beclomethasone dipropionate and Beclomethasone dipropionate may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Orciprenaline may cause a minor interaction that can limit clinical effects... |
DB01105 | DB09241 | 222 | 1,629 | [
"DDInter1665",
"DDInter1186"
] | Sibutramine | Methylene blue | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
222,
25,
1629
]
],
[
[
222,
63,
1052
],
[
1052,
24,
1629
]
],
[
[
222,
24,
697
],
[
697,
24,
1629
]
],
[
[
222,
24,
1032
],
[
1032,
... | [
[
[
"Sibutramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ritodrine"
],
[
"Ritod... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine and Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and... |
DB00620 | DB00745 | 175 | 307 | [
"DDInter1855",
"DDInter1236"
] | Triamcinolone | Modafinil | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Minor | 0 | [
[
[
175,
23,
307
]
],
[
[
175,
63,
362
],
[
362,
40,
307
]
],
[
[
175,
24,
651
],
[
651,
40,
307
]
],
[
[
175,
6,
8374
],
[
8374,
45... | [
[
[
"Triamcinolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Modafinil (Compound)
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and Fosphenytoin (Compound) resembles Modafinil (Comp... |
DB01041 | DB14881 | 770 | 180 | [
"DDInter1789",
"DDInter1329"
] | Thalidomide | Oliceridine | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
770,
24,
180
]
],
[
[
770,
63,
112
],
[
112,
23,
180
]
],
[
[
770,
24,
401
],
[
401,
24,
180
]
],
[
[
770,
63,
1184
],
[
1184,
2... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Oliceridine
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Promethazine a... |
DB01232 | DB11967 | 1,327 | 710 | [
"DDInter1640",
"DDInter210"
] | Saquinavir | Binimetinib | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
1327,
24,
710
]
],
[
[
1327,
25,
1593
],
[
1593,
24,
710
]
],
[
[
1327,
64,
1557
],
[
1557,
24,
710
]
],
[
[
1327,
63,
883
],
[
883,
... | [
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
"Crizotini... | Saquinavir may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Saquinavir may lead to a major life threatening interaction when taken with Astemizole and Astemizole may cause a moderate int... |
DB00321 | DB11130 | 21 | 407 | [
"DDInter78",
"DDInter1344"
] | Amitriptyline | Opium | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
21,
24,
407
]
],
[
[
21,
24,
662
],
[
662,
24,
407
]
],
[
[
21,
35,
1219
],
[
1219,
24,
407
]
],
[
[
21,
1,
1405
],
[
1405,
24,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Amitriptyline (Compound) resembles Azatadine (Compound) and Amitriptyline may cause a moderate interaction t... |
DB00420 | DB01128 | 508 | 918 | [
"DDInter1532",
"DDInter204"
] | Promazine | Bicalutamide | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
508,
24,
918
]
],
[
[
508,
24,
129
],
[
129,
40,
918
]
],
[
[
508,
6,
8374
],
[
8374,
45,
918
]
],
[
[
508,
23,
112
],
[
112,
23... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
... | Promazine may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Promazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bicalutamide (Compound)
Promazine may cause a minor interaction that can limit clini... |
DB01244 | DB06663 | 762 | 1,154 | [
"DDInter192",
"DDInter1398"
] | Bepridil | Pasireotide | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
762,
25,
1154
]
],
[
[
762,
63,
966
],
[
966,
40,
1154
]
],
[
[
762,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
762,
62,
112
],
[
112,
... | [
[
[
"Bepridil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Bepridil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
],
[
"Octreotide",
... | Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Bepridil (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Bepridil may cause a minor interacti... |
DB00712 | DB09268 | 1,274 | 1,662 | [
"DDInter763",
"DDInter1464"
] | Flurbiprofen | Picosulfuric acid | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1274,
24,
1662
]
],
[
[
1274,
23,
16
],
[
16,
23,
1662
]
],
[
[
1274,
63,
1252
],
[
1252,
23,
1662
]
],
[
[
1274,
24,
1619
],
[
1619,
... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Flurbiprofen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Linaclotide"
]... | Flurbiprofen may cause a minor interaction that can limit clinical effects when taken with Linaclotide and Linaclotide may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and ... |
DB00414 | DB02546 | 590 | 137 | [
"DDInter16",
"DDInter1947"
] | Acetohexamide | Vorinostat | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new clas... | Moderate | 1 | [
[
[
590,
24,
137
]
],
[
[
590,
24,
1144
],
[
1144,
24,
137
]
],
[
[
590,
24,
1344
],
[
1344,
63,
137
]
],
[
[
590,
63,
1645
],
[
1645,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vorinostat"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Vorinostat
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin... |
DB10316 | DB11988 | 334 | 270 | [
"DDInter1248",
"DDInter1321"
] | Mumps virus strain B level jeryl lynn live antigen | Ocrelizumab | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Major | 2 | [
[
[
334,
25,
270
]
],
[
[
334,
64,
134
],
[
134,
24,
270
]
],
[
[
334,
25,
1019
],
[
1019,
24,
270
]
],
[
[
334,
25,
398
],
[
398,
6... | [
[
[
"Mumps virus strain B level jeryl lynn live antigen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Mumps virus strain B level jeryl lynn live antigen",
"{u} may lead to a major life threatening interaction when ... | Mumps virus strain B level jeryl lynn live antigen may lead to a major life threatening interaction when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Mumps virus strain B level jeryl lynn live antigen may lead to a major life threaten... |
DB00334 | DB01233 | 867 | 1,311 | [
"DDInter1326",
"DDInter1197"
] | Olanzapine | Metoclopramide | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Major | 2 | [
[
[
867,
25,
1311
]
],
[
[
867,
24,
1151
],
[
1151,
40,
1311
]
],
[
[
867,
6,
5289
],
[
5289,
45,
1311
]
],
[
[
867,
24,
1010
],
[
1010,
... | [
[
[
"Olanzapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
],
[
"Sunitin... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Sunitinib (Compound) resembles Metoclopramide (Compound)
Olanzapine (Compound) binds DRD3 (Gene) and DRD3 (Gene) is bound by Metoclopramide (Compound)
Olanzapine may cause a moderate interaction that could exacerbat... |
DB00468 | DB09268 | 1,424 | 1,662 | [
"DDInter1557",
"DDInter1464"
] | Quinine | Picosulfuric acid | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Major | 2 | [
[
[
1424,
25,
1662
]
],
[
[
1424,
63,
1252
],
[
1252,
23,
1662
]
],
[
[
1424,
24,
1164
],
[
1164,
24,
1662
]
],
[
[
1424,
24,
484
],
[
484... | [
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[
"Digoxin",
... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramin... |
DB01083 | DB09061 | 1,142 | 1,627 | [
"DDInter1348",
"DDInter284"
] | Orlistat | Cannabidiol | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
1142,
24,
1627
]
],
[
[
1142,
24,
384
],
[
384,
23,
1627
]
],
[
[
1142,
24,
1613
],
[
1613,
63,
1627
]
],
[
[
1142,
63,
267
],
[
267,
... | [
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
... | Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and ... |
DB00836 | DB08871 | 543 | 36 | [
"DDInter1088",
"DDInter666"
] | Loperamide | Eribulin | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
543,
24,
36
]
],
[
[
543,
64,
122
],
[
122,
23,
36
]
],
[
[
543,
24,
519
],
[
519,
24,
36
]
],
[
[
543,
64,
1424
],
[
1424,
24,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Loperamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Verapamil"
],
[
"Verapamil",
... | Loperamide may lead to a major life threatening interaction when taken with Verapamil and Verapamil may cause a minor interaction that can limit clinical effects when taken with Eribulin
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone may cause a ... |
DB00289 | DB11113 | 847 | 657 | [
"DDInter132",
"DDInter307"
] | Atomoxetine | Castor oil | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
847,
24,
657
]
],
[
[
847,
24,
927
],
[
927,
63,
657
]
],
[
[
847,
24,
1491
],
[
1491,
24,
657
]
],
[
[
847,
25,
985
],
[
985,
2... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[... | Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and M... |
DB00364 | DB01246 | 417 | 820 | [
"DDInter1717",
"DDInter45"
] | Sucralfate | Alimemazine | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | A phenothiazine derivative that is used as an antipruritic. | Minor | 0 | [
[
[
417,
23,
820
]
],
[
[
417,
23,
104
],
[
104,
40,
820
]
],
[
[
417,
23,
401
],
[
401,
24,
820
]
],
[
[
417,
23,
508
],
[
508,
1,
... | [
[
[
"Sucralfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Alimemazine"
]
],
[
[
"Sucralfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Methdilazine"
],
[
... | Sucralfate may cause a minor interaction that can limit clinical effects when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Promethazine and Promethazine may cause a moderate interaction that ... |
DB00816 | DB00978 | 1,674 | 739 | [
"DDInter1346",
"DDInter1084"
] | Orciprenaline | Lomefloxacin | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Moderate | 1 | [
[
[
1674,
24,
739
]
],
[
[
1674,
25,
945
],
[
945,
40,
739
]
],
[
[
1674,
24,
872
],
[
872,
40,
739
]
],
[
[
1674,
64,
1176
],
[
1176,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Orciprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
],
[
"... | Orciprenaline may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Lomefloxacin (Compoun... |
DB01229 | DB12332 | 973 | 1,619 | [
"DDInter1378",
"DDInter1626"
] | Paclitaxel (protein-bound) | Rucaparib | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
973,
24,
1619
]
],
[
[
973,
62,
307
],
[
307,
23,
1619
]
],
[
[
973,
63,
112
],
[
112,
23,
1619
]
],
[
[
973,
24,
259
],
[
259,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Paclitaxel",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Paclitaxel may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Paclitaxel may cau... |
DB00580 | DB09134 | 311 | 1,552 | [
"DDInter1910",
"DDInter966"
] | Valdecoxib | Ioversol | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Major | 2 | [
[
[
311,
25,
1552
]
],
[
[
311,
24,
848
],
[
848,
25,
1552
]
],
[
[
311,
25,
629
],
[
629,
25,
1552
]
],
[
[
311,
63,
663
],
[
663,
... | [
[
[
"Valdecoxib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioversol"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[
"Ibuprofen",
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may lead to a major life threatening interaction when taken with Ioversol
Valdecoxib may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may lead to a major life threat... |
DB00279 | DB01406 | 1,152 | 984 | [
"DDInter1074",
"DDInter472"
] | Liothyronine | Danazol | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Moderate | 1 | [
[
[
1152,
24,
984
]
],
[
[
1152,
24,
1546
],
[
1546,
1,
984
]
],
[
[
1152,
24,
1026
],
[
1026,
40,
984
]
],
[
[
1152,
7,
13230
],
[
13230,... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Danazol"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
],... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Danazol (Compound)
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Oxandrolone and Oxandrolone (Compound) resembles Dan... |
DB00595 | DB09278 | 1,545 | 852 | [
"DDInter1374",
"DDInter24"
] | Oxytetracycline | Activated charcoal | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity... | Moderate | 1 | [
[
[
1545,
24,
852
]
],
[
[
1545,
40,
964
],
[
964,
24,
852
]
],
[
[
1545,
24,
126
],
[
126,
24,
852
]
],
[
[
1545,
63,
663
],
[
663,
... | [
[
[
"Oxytetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Activated charcoal"
]
],
[
[
"Oxytetracycline",
"{u} (Compound) resembles {v} (Compound)",
"Doxycycline"
],
[
"Doxycycline",
"{u}... | Oxytetracycline (Compound) resembles Doxycycline (Compound) and Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Activated charcoal
Oxytetracycline may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate intera... |
DB01284 | DB11827 | 1,042 | 433 | [
"DDInter1782",
"DDInter669"
] | Tetracosactide | Ertugliflozin | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1042,
24,
433
]
],
[
[
1042,
63,
1020
],
[
1020,
24,
433
]
],
[
[
1042,
24,
35
],
[
35,
24,
433
]
],
[
[
1042,
62,
688
],
[
688,
... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
]... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol a... |
DB00372 | DB01233 | 999 | 1,311 | [
"DDInter1793",
"DDInter1197"
] | Thiethylperazine | Metoclopramide | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Major | 2 | [
[
[
999,
25,
1311
]
],
[
[
999,
24,
817
],
[
817,
23,
1311
]
],
[
[
999,
24,
1020
],
[
1020,
24,
1311
]
],
[
[
999,
24,
643
],
[
643,
... | [
[
[
"Thiethylperazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dopamine"
],
[
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Dopamine and Dopamine may cause a minor interaction that can limit clinical effects when taken with Metoclopramide
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Clonidine a... |
DB00328 | DB12332 | 831 | 1,619 | [
"DDInter921",
"DDInter1626"
] | Indomethacin | Rucaparib | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
831,
24,
1619
]
],
[
[
831,
24,
222
],
[
222,
23,
1619
]
],
[
[
831,
24,
1662
],
[
1662,
24,
1619
]
],
[
[
831,
25,
1213
],
[
1213,
... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
... | Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid ... |
DB06697 | DB12095 | 436 | 179 | [
"DDInter121",
"DDInter1760"
] | Artemether | Telotristat ethyl | Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and may be used to treat infections caused by <i>P. falciparum</... | Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942] Currently, telotristat ... | Moderate | 1 | [
[
[
436,
24,
179
]
],
[
[
436,
24,
214
],
[
214,
24,
179
]
],
[
[
436,
24,
283
],
[
283,
63,
179
]
],
[
[
436,
63,
1324
],
[
1324,
2... | [
[
[
"Artemether",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telotristat ethyl"
]
],
[
[
"Artemether",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],... | Artemether may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl
Artemether may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib... |
DB00470 | DB01618 | 530 | 776 | [
"DDInter601",
"DDInter1239"
] | Dronabinol | Molindone | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Moderate | 1 | [
[
[
530,
24,
776
]
],
[
[
530,
21,
28680
],
[
28680,
60,
776
]
],
[
[
530,
24,
100
],
[
100,
24,
776
]
],
[
[
530,
24,
1662
],
[
1662,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Molindone"
]
],
[
[
"Dronabinol",
"{u} (Compound) causes {v} (Side Effect)",
"Rash"
],
[
"Rash",
"{u} (Side Effect) is caused by {v} (... | Dronabinol (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Molindone (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Molindon... |
DB00682 | DB12364 | 126 | 1,421 | [
"DDInter1951",
"DDInter200"
] | Warfarin | Betrixaban | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
126,
25,
1421
]
],
[
[
126,
23,
297
],
[
297,
23,
1421
]
],
[
[
126,
23,
1631
],
[
1631,
62,
1421
]
],
[
[
126,
24,
1091
],
[
1091,
... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u} ma... | Warfarin may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Betrixaban
Warfarin may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a minor i... |
DB00295 | DB01203 | 475 | 699 | [
"DDInter1244",
"DDInter1255"
] | Morphine | Nadolol | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Moderate | 1 | [
[
[
475,
24,
699
]
],
[
[
475,
24,
887
],
[
887,
1,
699
]
],
[
[
475,
6,
4973
],
[
4973,
45,
699
]
],
[
[
475,
21,
28882
],
[
28882,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nadolol"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
],
[
"Pind... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Nadolol (Compound)
Morphine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nadolol (Compound)
Morphine (Compound) causes Body temperature increased (Side Effect) and Body tempe... |
DB00834 | DB08871 | 932 | 36 | [
"DDInter1215",
"DDInter666"
] | Mifepristone | Eribulin | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Major | 2 | [
[
[
932,
25,
36
]
],
[
[
932,
18,
16974
],
[
16974,
45,
36
]
],
[
[
932,
24,
973
],
[
973,
24,
36
]
],
[
[
932,
64,
1424
],
[
1424,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eribulin"
]
],
[
[
"Mifepristone",
"{u} (Compound) downregulates {v} (Gene)",
"TUBB6"
],
[
"TUBB6",
"{u} (Gene) is bound by {v} (Compound)",
... | Mifepristone (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Eribulin (Compound)
Mifepristone may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Mifepristone... |
DB00196 | DB00679 | 600 | 684 | [
"DDInter743",
"DDInter1796"
] | Fluconazole | Thioridazine | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Major | 2 | [
[
[
600,
25,
684
]
],
[
[
600,
24,
1237
],
[
1237,
40,
684
]
],
[
[
600,
24,
216
],
[
216,
1,
684
]
],
[
[
600,
6,
10215
],
[
10215,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
[
"Clom... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Thioridazine (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine (Compound) resembles Thiori... |
DB11817 | DB11921 | 1,259 | 1,019 | [
"DDInter165",
"DDInter492"
] | Baricitinib | Deflazacort | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
1259,
25,
1019
]
],
[
[
1259,
62,
1193
],
[
1193,
23,
1019
]
],
[
[
1259,
25,
270
],
[
270,
63,
1019
]
],
[
[
1259,
63,
914
],
[
914,
... | [
[
[
"Baricitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Baricitinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc ... | Baricitinib may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Baricitinib may lead to a major life threatening interaction when taken with Ocrelizumab and Ocrelizumab m... |
DB00461 | DB01166 | 598 | 477 | [
"DDInter1254",
"DDInter379"
] | Nabumetone | Cilostazol | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
598,
24,
477
]
],
[
[
598,
6,
7950
],
[
7950,
45,
477
]
],
[
[
598,
18,
2201
],
[
2201,
57,
477
]
],
[
[
598,
21,
29340
],
[
29340,
... | [
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Nabumetone",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",... | Nabumetone (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Cilostazol (Compound)
Nabumetone (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) is downregulated by Cilostazol (Compound)
Nabumetone (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is ... |
DB00099 | DB08871 | 440 | 36 | [
"DDInter735",
"DDInter666"
] | Filgrastim | Eribulin | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
440,
24,
36
]
],
[
[
440,
24,
1488
],
[
1488,
24,
36
]
],
[
[
440,
63,
599
],
[
599,
24,
36
]
],
[
[
440,
24,
384
],
[
384,
63,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemt... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.