drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00457 | DB01143 | 1,205 | 923 | [
"DDInter1511",
"DDInter65"
] | Prazosin | Amifostine | Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988. It belongs to the class of drugs known as alpha-1 antagonists. Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTS... | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
1205,
24,
923
]
],
[
[
1205,
21,
28642
],
[
28642,
60,
923
]
],
[
[
1205,
40,
1433
],
[
1433,
24,
923
]
],
[
[
1205,
24,
714
],
[
714,... | [
[
[
"Prazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Prazosin",
"{u} (Compound) causes {v} (Side Effect)",
"Shock"
],
[
"Shock",
"{u} (Side Effect) is caused by {v} (C... | Prazosin (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Amifostine (Compound)
Prazosin (Compound) resembles Doxazosin (Compound) and Doxazosin may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Prazosin may cause a moderate interaction that could exace... |
DB06777 | DB14761 | 780 | 242 | [
"DDInter348",
"DDInter1578"
] | Chenodeoxycholic acid | Remdesivir | Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver and absorption in the intestines, which helps to decre... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
780,
24,
242
]
],
[
[
780,
64,
1377
],
[
1377,
24,
242
]
],
[
[
780,
24,
384
],
[
384,
24,
242
]
],
[
[
780,
63,
482
],
[
482,
2... | [
[
[
"Chenodeoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Chenodeoxycholic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
],
... | Chenodeoxycholic acid may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Chenodeoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib a... |
DB00060 | DB01320 | 912 | 651 | [
"DDInter947",
"DDInter783"
] | Interferon beta-1a | Fosphenytoin | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
912,
24,
651
]
],
[
[
912,
24,
362
],
[
362,
1,
651
]
],
[
[
912,
24,
1101
],
[
1101,
23,
651
]
],
[
[
912,
24,
26
],
[
26,
63,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interacti... |
DB01208 | DB14491 | 945 | 428 | [
"DDInter1705",
"DDInter725"
] | Sparfloxacin | Ferrous fumarate | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Used in treatment of iron deficiency anemia. | Moderate | 1 | [
[
[
945,
24,
428
]
],
[
[
945,
63,
1096
],
[
1096,
23,
428
]
],
[
[
945,
24,
1193
],
[
1193,
23,
428
]
],
[
[
945,
40,
246
],
[
246,
... | [
[
[
"Sparfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Sparfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid... | Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Ferrous fumarate
Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00092 | DB11793 | 58 | 738 | [
"DDInter40",
"DDInter1297"
] | Alefacept | Niraparib | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
58,
24,
738
]
],
[
[
58,
24,
1213
],
[
1213,
24,
738
]
],
[
[
58,
24,
1619
],
[
1619,
63,
738
]
],
[
[
58,
63,
305
],
[
305,
24,... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib ma... |
DB08867 | DB11760 | 807 | 119 | [
"DDInter1897",
"DDInter1742"
] | Ulipristal | Talazoparib | Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocor... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
807,
24,
119
]
],
[
[
807,
24,
214
],
[
214,
63,
119
]
],
[
[
807,
24,
351
],
[
351,
24,
119
]
],
[
[
807,
63,
578
],
[
578,
24,... | [
[
[
"Ulipristal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Ulipristal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[... | Ulipristal may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Ulipristal may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and R... |
DB08880 | DB15233 | 1,510 | 1,650 | [
"DDInter1771",
"DDInter142"
] | Teriflunomide | Avapritinib | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
1510,
25,
1650
]
],
[
[
1510,
64,
1478
],
[
1478,
24,
1650
]
],
[
[
1510,
25,
159
],
[
159,
24,
1650
]
],
[
[
1510,
63,
1430
],
[
1430... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
],
[
"Ivacaftor",
"... | Teriflunomide may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Teriflunomide may lead to a major life threatening interaction when taken with Larotrectinib and Larotrectinib may cause a mo... |
DB01208 | DB12141 | 945 | 971 | [
"DDInter1705",
"DDInter817"
] | Sparfloxacin | Gilteritinib | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Major | 2 | [
[
[
945,
25,
971
]
],
[
[
945,
62,
112
],
[
112,
23,
971
]
],
[
[
945,
64,
485
],
[
485,
24,
971
]
],
[
[
945,
25,
823
],
[
823,
63,... | [
[
[
"Sparfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
]
],
[
[
"Sparfloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Sparfloxacin may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine ... |
DB00242 | DB06643 | 1,064 | 1,136 | [
"DDInter392",
"DDInter500"
] | Cladribine | Denosumab | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Major | 2 | [
[
[
1064,
25,
1136
]
],
[
[
1064,
25,
1213
],
[
1213,
24,
1136
]
],
[
[
1064,
25,
1316
],
[
1316,
63,
1136
]
],
[
[
1064,
64,
1648
],
[
16... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Denosumab"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatinib",
"{u} may ... | Cladribine may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Cladribine may lead to a major life threatening interaction when taken with Durvalumab and Durvalumab may cause a moderate interac... |
DB06207 | DB08875 | 910 | 1,618 | [
"DDInter1667",
"DDInter262"
] | Silodosin | Cabozantinib | Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenocepto... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Moderate | 1 | [
[
[
910,
24,
1618
]
],
[
[
910,
63,
723
],
[
723,
24,
1618
]
],
[
[
910,
25,
384
],
[
384,
63,
1618
]
],
[
[
910,
24,
1040
],
[
1040,
... | [
[
[
"Silodosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabozantinib"
]
],
[
[
"Silodosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Silodosin may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib
Silodosin may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may cause ... |
DB00630 | DB08938 | 1,485 | 1,384 | [
"DDInter42",
"DDInter1112"
] | Alendronic acid | Magaldrate | Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
1485,
24,
1384
]
],
[
[
1485,
62,
752
],
[
752,
23,
1384
]
],
[
[
1485,
23,
1559
],
[
1559,
23,
1384
]
],
[
[
1485,
24,
428
],
[
428,
... | [
[
[
"Alendronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Alendronic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
],
... | Alendronic acid may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Alendronic acid may cause a minor interaction that can limit clinical effects when taken with Famotidine and Fa... |
DB00424 | DB00836 | 19 | 543 | [
"DDInter896",
"DDInter1088"
] | Hyoscyamine | Loperamide | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
19,
24,
543
]
],
[
[
19,
24,
704
],
[
704,
40,
543
]
],
[
[
19,
24,
675
],
[
675,
24,
543
]
],
[
[
19,
63,
701
],
[
701,
24,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Loperamide (Compound)
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene may cause a moderate interact... |
DB01041 | DB06788 | 770 | 1,616 | [
"DDInter1789",
"DDInter864"
] | Thalidomide | Histrelin | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
770,
24,
1616
]
],
[
[
770,
63,
112
],
[
112,
23,
1616
]
],
[
[
770,
63,
1664
],
[
1664,
24,
1616
]
],
[
[
770,
24,
623
],
[
623,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and ... |
DB08904 | DB14962 | 375 | 1,363 | [
"DDInter342",
"DDInter1847"
] | Certolizumab pegol | Trastuzumab deruxtecan | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Trastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of treatment-resistant HER2-positive cancers. It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes i... | Major | 2 | [
[
[
375,
25,
1363
]
],
[
[
375,
63,
1430
],
[
1430,
24,
1363
]
],
[
[
375,
25,
384
],
[
384,
24,
1363
]
],
[
[
375,
64,
1531
],
[
1531,
... | [
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trastuzumab deruxtecan"
]
],
[
[
"Certolizumab pegol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
... | Certolizumab pegol may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab deruxtecan
Certolizumab pegol may lead to a major life threatening interaction when taken with Idel... |
DB01227 | DB04843 | 1,301 | 1,511 | [
"DDInter1043",
"DDInter1149"
] | Levacetylmethadol | Mepenzolate | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
1301,
24,
1511
]
],
[
[
1301,
40,
675
],
[
675,
24,
1511
]
],
[
[
1301,
63,
1192
],
[
1192,
24,
1511
]
],
[
[
1301,
74,
262
],
[
262,
... | [
[
[
"Levacetylmethadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Levacetylmethadol",
"{u} (Compound) resembles {v} (Compound)",
"Dextropropoxyphene"
],
[
"Dextropropoxyphene",... | Levacetylmethadol (Compound) resembles Dextropropoxyphene (Compound) and Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Levacetylmethadol may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium and Glycopyrronium may ... |
DB06772 | DB11718 | 310 | 927 | [
"DDInter259",
"DDInter640"
] | Cabazitaxel | Encorafenib | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
310,
24,
927
]
],
[
[
310,
63,
112
],
[
112,
23,
927
]
],
[
[
310,
63,
536
],
[
536,
24,
927
]
],
[
[
310,
24,
578
],
[
578,
24,... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital a... |
DB05273 | DB12498 | 507 | 76 | [
"DDInter1638",
"DDInter1238"
] | Samarium (153Sm) lexidronam | Mogamulizumab | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Mogamulizumab is a humanized monoclonal antibody (mAb) directed against CC chemokine receptor 4 (CCR4) for the treatment of Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most common subtypes of cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain white blood cells, called T cells, become canc... | Major | 2 | [
[
[
507,
25,
76
]
],
[
[
507,
25,
384
],
[
384,
24,
76
]
],
[
[
507,
63,
248
],
[
248,
24,
76
]
],
[
[
507,
64,
4
],
[
4,
24,
... | [
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mogamulizumab"
]
],
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
],
... | Samarium (153Sm) lexidronam may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Mogamulizumab
Samarium (153Sm) lexidronam may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01001 | DB08918 | 688 | 41 | [
"DDInter1632",
"DDInter1059"
] | Salbutamol | Levomilnacipran | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
688,
24,
41
]
],
[
[
688,
24,
901
],
[
901,
40,
41
]
],
[
[
688,
6,
8374
],
[
8374,
45,
41
]
],
[
[
688,
21,
28643
],
[
28643,
6... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
],
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Salbutamol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levomilnacipran (Compound)
Salbutamol (Compound) causes Infection (Side Effect) a... |
DB00673 | DB06077 | 723 | 879 | [
"DDInter112",
"DDInter1102"
] | Aprepitant | Lumateperone | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Major | 2 | [
[
[
723,
25,
879
]
],
[
[
723,
24,
214
],
[
214,
63,
879
]
],
[
[
723,
24,
392
],
[
392,
24,
879
]
],
[
[
723,
63,
597
],
[
597,
24,... | [
[
[
"Aprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumateperone"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[
"Fostam... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and L... |
DB01069 | DB01276 | 401 | 123 | [
"DDInter1533",
"DDInter706"
] | Promethazine | Exenatide | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
401,
24,
123
]
],
[
[
401,
63,
867
],
[
867,
24,
123
]
],
[
[
401,
24,
1539
],
[
1539,
24,
123
]
],
[
[
401,
74,
1630
],
[
1630,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olanzapine"
],
[... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Olanzapine and Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin and Oflo... |
DB00434 | DB00543 | 13 | 87 | [
"DDInter459",
"DDInter82"
] | Cyproheptadine | Amoxapine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Moderate | 1 | [
[
[
13,
24,
87
]
],
[
[
13,
24,
1119
],
[
1119,
1,
87
]
],
[
[
13,
63,
905
],
[
905,
40,
87
]
],
[
[
13,
63,
1174
],
[
1174,
1,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amoxapine"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlordiazepoxide"
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Chlordiazepoxide and Chlordiazepoxide (Compound) resembles Amoxapine (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Lorazepam and Lorazepam (Compound) resembles Amoxa... |
DB00445 | DB12825 | 322 | 1,375 | [
"DDInter655",
"DDInter1032"
] | Epirubicin | Lefamulin | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Major | 2 | [
[
[
322,
25,
1375
]
],
[
[
322,
23,
112
],
[
112,
23,
1375
]
],
[
[
322,
24,
159
],
[
159,
63,
1375
]
],
[
[
322,
24,
1532
],
[
1532,
... | [
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lefamulin"
]
],
[
[
"Epirubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Epirubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and La... |
DB08895 | DB12674 | 976 | 975 | [
"DDInter1825",
"DDInter1105"
] | Tofacitinib | Lurbinectedin | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Major | 2 | [
[
[
976,
25,
975
]
],
[
[
976,
64,
1488
],
[
1488,
24,
975
]
],
[
[
976,
24,
159
],
[
159,
63,
975
]
],
[
[
976,
24,
98
],
[
98,
24,... | [
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fludarabine"
],
[
"Fludarabine",
... | Tofacitinib may lead to a major life threatening interaction when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectin... |
DB00218 | DB01362 | 1,176 | 497 | [
"DDInter1247",
"DDInter960"
] | Moxifloxacin | Iohexol | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1176,
25,
497
]
],
[
[
1176,
21,
29750
],
[
29750,
60,
497
]
],
[
[
1176,
25,
891
],
[
891,
25,
497
]
],
[
[
1176,
1,
246
],
[
246,
... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Injection site pain"
],
[
"Injection site pain",
"{u} (Side Effect) i... | Moxifloxacin (Compound) causes Injection site pain (Side Effect) and Injection site pain (Side Effect) is caused by Iohexol (Compound)
Moxifloxacin may lead to a major life threatening interaction when taken with Prednisolone and Prednisolone may lead to a major life threatening interaction when taken with Iohexol
Moxi... |
DB00762 | DB08913 | 613 | 1,186 | [
"DDInter973",
"DDInter1561"
] | Irinotecan | Radium Ra 223 dichloride | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
613,
24,
1186
]
],
[
[
613,
21,
28872
],
[
28872,
60,
1186
]
],
[
[
613,
24,
1491
],
[
1491,
24,
1186
]
],
[
[
613,
24,
1619
],
[
1619... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Irinotecan",
"{u} (Compound) causes {v} (Side Effect)",
"Extravasation"
],
[
"Extravasation",
"{u}... | Irinotecan (Compound) causes Extravasation (Side Effect) and Extravasation (Side Effect) is caused by Radium Ra 223 dichloride (Compound)
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases... |
DB00400 | DB11853 | 353 | 230 | [
"DDInter843",
"DDInter1577"
] | Griseofulvin | Relugolix | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions. It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids, and more recently by the United States' FDA in 2020, under th... | Minor | 0 | [
[
[
353,
23,
230
]
],
[
[
353,
24,
129
],
[
129,
23,
230
]
],
[
[
353,
62,
1101
],
[
1101,
23,
230
]
],
[
[
353,
24,
1476
],
[
1476,
... | [
[
[
"Griseofulvin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Relugolix"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Relugolix
Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bex... |
DB01254 | DB01591 | 1,213 | 667 | [
"DDInter484",
"DDInter1696"
] | Dasatinib | Solifenacin | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Moderate | 1 | [
[
[
1213,
24,
667
]
],
[
[
1213,
6,
8374
],
[
8374,
45,
667
]
],
[
[
1213,
21,
28743
],
[
28743,
60,
667
]
],
[
[
1213,
62,
112
],
[
112,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solifenacin"
]
],
[
[
"Dasatinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Dasatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Solifenacin (Compound)
Dasatinib (Compound) causes Atrial fibrillation (Side Effect) and Atrial fibrillation (Side Effect) is caused by Solifenacin (Compound)
Dasatinib may cause a minor interaction that can limit clinical effects when taken with Me... |
DB00668 | DB01203 | 874 | 699 | [
"DDInter652",
"DDInter1255"
] | Epinephrine | Nadolol | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Major | 2 | [
[
[
874,
25,
699
]
],
[
[
874,
25,
729
],
[
729,
1,
699
]
],
[
[
874,
40,
604
],
[
604,
1,
699
]
],
[
[
874,
6,
3576
],
[
3576,
45,
... | [
[
[
"Epinephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nadolol"
]
],
[
[
"Epinephrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Penbutolol"
],
[
"Penbutolol",
"{u} (C... | Epinephrine may lead to a major life threatening interaction when taken with Penbutolol and Penbutolol (Compound) resembles Nadolol (Compound)
Epinephrine (Compound) resembles Pirbuterol (Compound) and Pirbuterol (Compound) resembles Nadolol (Compound)
Epinephrine (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is bound... |
DB00995 | DB01611 | 1,112 | 1,487 | [
"DDInter139",
"DDInter893"
] | Auranofin | Hydroxychloroquine | Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme ox... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
1112,
25,
1487
]
],
[
[
1112,
25,
1520
],
[
1520,
25,
1487
]
],
[
[
1112,
7,
2216
],
[
2216,
46,
1487
]
],
[
[
1112,
21,
28658
],
[
28... | [
[
[
"Auranofin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Auranofin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primaquine"
],
[
"Primaquine",
... | Auranofin may lead to a major life threatening interaction when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Auranofin (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Hydroxychloroquine (Compound)
Auranofin (Compound) cause... |
DB00515 | DB04845 | 589 | 309 | [
"DDInter387",
"DDInter1001"
] | Cisplatin | Ixabepilone | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
589,
24,
309
]
],
[
[
589,
21,
28736
],
[
28736,
60,
309
]
],
[
[
589,
24,
60
],
[
60,
23,
309
]
],
[
[
589,
24,
1419
],
[
1419,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Cisplatin",
"{u} (Compound) causes {v} (Side Effect)",
"Dehydration"
],
[
"Dehydration",
"{u} (Side Effect) is c... | Cisplatin (Compound) causes Dehydration (Side Effect) and Dehydration (Side Effect) is caused by Ixabepilone (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Capecitabine and Capecitabine may cause a minor interaction that can limit clinical effects when taken with Ix... |
DB00009 | DB00963 | 1,271 | 1,263 | [
"DDInter56",
"DDInter241"
] | Alteplase | Bromfenac | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Moderate | 1 | [
[
[
1271,
24,
1263
]
],
[
[
1271,
24,
935
],
[
935,
40,
1263
]
],
[
[
1271,
24,
1512
],
[
1512,
24,
1263
]
],
[
[
1271,
24,
578
],
[
578,
... | [
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromfenac"
]
],
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
[
... | Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Bromfenac (Compound)
Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could ex... |
DB00261 | DB04844 | 702 | 843 | [
"DDInter93",
"DDInter1778"
] | Anagrelide | Tetrabenazine | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Major | 2 | [
[
[
702,
25,
843
]
],
[
[
702,
24,
479
],
[
479,
40,
843
]
],
[
[
702,
21,
28698
],
[
28698,
60,
843
]
],
[
[
702,
23,
112
],
[
112,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tetrabenazine"
]
],
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],
[
"Donepezi... | Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil (Compound) resembles Tetrabenazine (Compound)
Anagrelide (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Tetrabenazine (Compound)
Anagrelide may cause a minor interaction t... |
DB00001 | DB00081 | 1,578 | 273 | [
"DDInter1037",
"DDInter1838"
] | Lepirudin | Tositumomab | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Major | 2 | [
[
[
1578,
25,
273
]
],
[
[
1578,
23,
539
],
[
539,
62,
273
]
],
[
[
1578,
24,
109
],
[
109,
63,
273
]
],
[
[
1578,
25,
702
],
[
702,
... | [
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tositumomab"
]
],
[
[
"Lepirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Lepirudin may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Tositumomab
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine may ... |
DB00877 | DB13928 | 629 | 1,385 | [
"DDInter1678",
"DDInter1660"
] | Sirolimus | Semaglutide | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
629,
24,
1385
]
],
[
[
629,
25,
1399
],
[
1399,
63,
1385
]
],
[
[
629,
63,
839
],
[
839,
24,
1385
]
],
[
[
629,
24,
1476
],
[
1476,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lithium carbonate"
],
[
"Lith... | Sirolimus may lead to a major life threatening interaction when taken with Lithium carbonate and Lithium carbonate may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Grepafloxacin and Grepa... |
DB01132 | DB01320 | 1,130 | 651 | [
"DDInter1472",
"DDInter783"
] | Pioglitazone | Fosphenytoin | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
1130,
24,
651
]
],
[
[
1130,
62,
307
],
[
307,
1,
651
]
],
[
[
1130,
63,
362
],
[
362,
1,
651
]
],
[
[
1130,
6,
6017
],
[
6017,
... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Pioglitazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[... | Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Fosphenytoin (Compound)
Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound... |
DB00717 | DB06292 | 1,197 | 549 | [
"DDInter1312",
"DDInter474"
] | Norethisterone | Dapagliflozin | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1197,
24,
549
]
],
[
[
1197,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1197,
6,
8374
],
[
8374,
45,
549
]
],
[
[
1197,
21,
28787
],
[
28787... | [
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
... | Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Norethisterone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Norethisterone (Compound) causes Dermatitis (S... |
DB00060 | DB00740 | 912 | 424 | [
"DDInter947",
"DDInter1596"
] | Interferon beta-1a | Riluzole | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi. | Moderate | 1 | [
[
[
912,
24,
424
]
],
[
[
912,
24,
1031
],
[
1031,
23,
424
]
],
[
[
912,
63,
305
],
[
305,
24,
424
]
],
[
[
912,
24,
482
],
[
482,
2... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Riluzole"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a minor interaction that can limit clinical effects when taken with Riluzole
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Aspar... |
DB00046 | DB00780 | 1,179 | 551 | [
"DDInter940",
"DDInter1440"
] | Insulin lispro | Phenelzine | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | Moderate | 1 | [
[
[
1179,
24,
551
]
],
[
[
1179,
24,
1161
],
[
1161,
40,
551
]
],
[
[
1179,
24,
73
],
[
73,
25,
551
]
],
[
[
1179,
24,
999
],
[
999,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selegiline"
],
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Selegiline and Selegiline (Compound) resembles Phenelzine (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may lead to a major life threaten... |
DB00063 | DB00569 | 366 | 553 | [
"DDInter659",
"DDInter775"
] | Eptifibatide | Fondaparinux | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Major | 2 | [
[
[
366,
25,
553
]
],
[
[
366,
23,
539
],
[
539,
62,
553
]
],
[
[
366,
24,
972
],
[
972,
63,
553
]
],
[
[
366,
24,
1416
],
[
1416,
2... | [
[
[
"Eptifibatide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fondaparinux"
]
],
[
[
"Eptifibatide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum... | Eptifibatide may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Fondaparinux
Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate and ... |
DB00531 | DB01319 | 450 | 34 | [
"DDInter456",
"DDInter777"
] | Cyclophosphamide | Fosamprenavir | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Moderate | 1 | [
[
[
450,
24,
34
]
],
[
[
450,
24,
1091
],
[
1091,
40,
34
]
],
[
[
450,
6,
8374
],
[
8374,
45,
34
]
],
[
[
450,
21,
28835
],
[
28835,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
]
],
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
... | Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Amprenavir and Amprenavir (Compound) resembles Fosamprenavir (Compound)
Cyclophosphamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosamprenavir (Compound)
Cyclophosphamide (Compound) causes Hyperglycaemi... |
DB01267 | DB01619 | 519 | 830 | [
"DDInter1381",
"DDInter1441"
] | Paliperidone | Phenindamine | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
519,
24,
830
]
],
[
[
519,
63,
537
],
[
537,
40,
830
]
],
[
[
519,
63,
13
],
[
13,
24,
830
]
],
[
[
519,
6,
10104
],
[
10104,
45... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
... | Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interactio... |
DB00209 | DB00331 | 352 | 1,645 | [
"DDInter1886",
"DDInter1164"
] | Trospium | Metformin | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Moderate | 1 | [
[
[
352,
24,
1645
]
],
[
[
352,
21,
28714
],
[
28714,
60,
1645
]
],
[
[
352,
24,
108
],
[
108,
62,
1645
]
],
[
[
352,
24,
1290
],
[
1290,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
]
],
[
[
"Trospium",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is caused by {... | Trospium (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Metformin (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Memantine and Memantine may cause a minor interaction that can limit clinical effects when taken with Metformin
Trospium... |
DB01075 | DB09065 | 1,376 | 760 | [
"DDInter569",
"DDInter424"
] | Diphenhydramine | Cobicistat | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1376,
24,
760
]
],
[
[
1376,
63,
479
],
[
479,
23,
760
]
],
[
[
1376,
24,
1627
],
[
1627,
23,
760
]
],
[
[
1376,
63,
523
],
[
523,
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
],... | Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and... |
DB00258 | DB01193 | 666 | 819 | [
"DDInter270",
"DDInter12"
] | Calcium acetate | Acebutolol | The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Moderate | 1 | [
[
[
666,
24,
819
]
],
[
[
666,
24,
887
],
[
887,
1,
819
]
],
[
[
666,
21,
28653
],
[
28653,
60,
819
]
],
[
[
666,
24,
542
],
[
542,
... | [
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
]
],
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
],
... | Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Calcium acetate (Compound) causes Bradycardia (Side Effect) and Bradycardia (Side Effect) is caused by Acebutolol (Compound)
Calcium acetate may cause a modera... |
DB01320 | DB15091 | 651 | 676 | [
"DDInter783",
"DDInter1901"
] | Fosphenytoin | Upadacitinib | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
651,
25,
676
]
],
[
[
651,
25,
283
],
[
283,
24,
676
]
],
[
[
651,
64,
600
],
[
600,
24,
676
]
],
[
[
651,
24,
1040
],
[
1040,
2... | [
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
],
[
"Fedratinib",
... | Fosphenytoin may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Fosphenytoin may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moder... |
DB09570 | DB11932 | 1,480 | 327 | [
"DDInter1002",
"DDInter3"
] | Ixazomib | Abametapir (topical) | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
1480,
24,
327
]
],
[
[
1480,
63,
168
],
[
168,
24,
327
]
],
[
[
1480,
64,
976
],
[
976,
24,
327
]
],
[
[
1480,
25,
676
],
[
676,
... | [
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Ixazomib may l... |
DB10344 | DB11703 | 992 | 405 | [
"DDInter818",
"DDInter9"
] | Ginger | Acalabrutinib | Ginger allergenic extract is used in allergenic testing. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
992,
24,
405
]
],
[
[
992,
24,
1297
],
[
1297,
63,
405
]
],
[
[
992,
63,
126
],
[
126,
25,
405
]
],
[
[
992,
24,
710
],
[
710,
6... | [
[
[
"Ginger",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Ginger",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
],
[
... | Ginger may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat and Osilodrostat may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Ginger may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin ... |
DB00673 | DB00976 | 723 | 1,056 | [
"DDInter112",
"DDInter1758"
] | Aprepitant | Telithromycin | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Moderate | 1 | [
[
[
723,
24,
1056
]
],
[
[
723,
6,
7950
],
[
7950,
45,
1056
]
],
[
[
723,
21,
29346
],
[
29346,
60,
1056
]
],
[
[
723,
24,
1220
],
[
1220,... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telithromycin"
]
],
[
[
"Aprepitant",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound... | Aprepitant (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Telithromycin (Compound)
Aprepitant (Compound) causes Upset stomach (Side Effect) and Upset stomach (Side Effect) is caused by Telithromycin (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Dexam... |
DB12364 | DB15035 | 1,421 | 503 | [
"DDInter200",
"DDInter1959"
] | Betrixaban | Zanubrutinib | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa. It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity. Betrixaban, now developed by Portola Pharmaceuticals In... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
1421,
25,
503
]
],
[
[
1421,
64,
868
],
[
868,
24,
503
]
],
[
[
1421,
63,
222
],
[
222,
24,
503
]
],
[
[
1421,
64,
39
],
[
39,
2... | [
[
[
"Betrixaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Betrixaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
],
[
"Vemurafenib",
"{... | Betrixaban may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Betrixaban may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may ... |
DB00348 | DB01115 | 254 | 336 | [
"DDInter1300",
"DDInter1291"
] | Nitisinone | Nifedipine | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Moderate | 1 | [
[
[
254,
24,
336
]
],
[
[
254,
24,
376
],
[
376,
1,
336
]
],
[
[
254,
21,
28688
],
[
28688,
60,
336
]
],
[
[
254,
24,
578
],
[
578,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
],
[
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) resembles Nifedipine (Compound)
Nitisinone (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Nifedipine (Compound)
Nitisinone may cause a moderate interaction ... |
DB00774 | DB09472 | 1,577 | 1,383 | [
"DDInter889",
"DDInter1693"
] | Hydroflumethiazide | Sodium sulfate | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1577,
24,
1383
]
],
[
[
1577,
40,
674
],
[
674,
24,
1383
]
],
[
[
1577,
24,
104
],
[
104,
24,
1383
]
],
[
[
1577,
63,
475
],
[
475,
... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Hydroflumethiazide",
"{u} (Compound) resembles {v} (Compound)",
"Trichlormethiazide"
],
[
"Trichlormethiaz... | Hydroflumethiazide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may... |
DB06077 | DB11827 | 879 | 433 | [
"DDInter1102",
"DDInter669"
] | Lumateperone | Ertugliflozin | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
879,
24,
433
]
],
[
[
879,
63,
959
],
[
959,
24,
433
]
],
[
[
879,
64,
609
],
[
609,
24,
433
]
],
[
[
879,
25,
1476
],
[
1476,
6... | [
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Lumateperone may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromyc... |
DB00264 | DB09340 | 88 | 1,013 | [
"DDInter1200",
"DDInter1895"
] | Metoprolol | Tyropanoic acid | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Tyropanoic acid is a radiocontrast agent used in cholecystography, the X-ray diagnosis of gallstones under the trade names include Bilopaque, Lumopaque, Tyropaque, and Bilopac. The molecule contains three heavy iodine atoms which obstruct X-rays in the same way as the calcium in bones, which results in a visible image ... | Moderate | 1 | [
[
[
88,
24,
1013
]
],
[
[
88,
24,
777
],
[
777,
24,
1013
]
],
[
[
88,
1,
819
],
[
819,
24,
1013
]
],
[
[
88,
40,
726
],
[
726,
24,
... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tyropanoic acid"
]
],
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopromide"
],
... | Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Iopromide and Iopromide may cause a moderate interaction that could exacerbate diseases when taken with Tyropanoic acid
Metoprolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction that co... |
DB01098 | DB08860 | 14 | 788 | [
"DDInter1622",
"DDInter1479"
] | Rosuvastatin | Pitavastatin | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Moderate | 1 | [
[
[
14,
35,
788
]
],
[
[
14,
63,
671
],
[
671,
1,
788
]
],
[
[
14,
63,
700
],
[
700,
40,
788
]
],
[
[
14,
5,
11576
],
[
11576,
44,
... | [
[
[
"Rosuvastatin",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
]
],
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when t... | Rosuvastatin (Compound) resembles Pitavastatin (Compound) and
Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin (Compound) resembles Pitavastatin (Compound)
Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB08901 | DB12500 | 1,468 | 283 | [
"DDInter1492",
"DDInter714"
] | Ponatinib | Fedratinib | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
1468,
25,
283
]
],
[
[
1468,
24,
351
],
[
351,
23,
283
]
],
[
[
1468,
63,
1593
],
[
1593,
23,
283
]
],
[
[
1468,
24,
1339
],
[
1339,
... | [
[
[
"Ponatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
"Ribociclib",... | Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib... |
DB00581 | DB00959 | 355 | 1,486 | [
"DDInter1018",
"DDInter1191"
] | Lactulose | Methylprednisolone | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
355,
24,
1486
]
],
[
[
355,
24,
175
],
[
175,
40,
1486
]
],
[
[
355,
24,
167
],
[
167,
1,
1486
]
],
[
[
355,
63,
251
],
[
251,
1... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Me... |
DB04868 | DB13139 | 478 | 1,032 | [
"DDInter1293",
"DDInter1063"
] | Nilotinib | Levosalbutamol | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
478,
24,
1032
]
],
[
[
478,
63,
1573
],
[
1573,
23,
1032
]
],
[
[
478,
64,
1220
],
[
1220,
23,
1032
]
],
[
[
478,
25,
1618
],
[
1618,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Nilotinib may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone may ... |
DB01246 | DB06292 | 820 | 549 | [
"DDInter45",
"DDInter474"
] | Alimemazine | Dapagliflozin | A phenothiazine derivative that is used as an antipruritic. | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
820,
24,
549
]
],
[
[
820,
24,
1344
],
[
1344,
40,
549
]
],
[
[
820,
6,
8374
],
[
8374,
45,
549
]
],
[
[
820,
21,
28882
],
[
28882,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Alimemazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Alimemazine (Compound) causes Body temperature incre... |
DB01229 | DB12887 | 973 | 1,598 | [
"DDInter1378",
"DDInter1750"
] | Paclitaxel (protein-bound) | Tazemetostat | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Moderate | 1 | [
[
[
973,
24,
1598
]
],
[
[
973,
63,
168
],
[
168,
23,
1598
]
],
[
[
973,
24,
310
],
[
310,
24,
1598
]
],
[
[
973,
63,
134
],
[
134,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Tazemetostat
Paclitax... |
DB00604 | DB06402 | 1,425 | 1,079 | [
"DDInter385",
"DDInter1756"
] | Cisapride | Telavancin | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Major | 2 | [
[
[
1425,
25,
1079
]
],
[
[
1425,
23,
112
],
[
112,
23,
1079
]
],
[
[
1425,
24,
657
],
[
657,
63,
1079
]
],
[
[
1425,
24,
543
],
[
543,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Telavancin"
]
],
[
[
"Cisapride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazo... | Cisapride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Telavancin
Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Castor oil and Castor... |
DB00563 | DB01250 | 663 | 712 | [
"DDInter1174",
"DDInter1334"
] | Methotrexate | Olsalazine | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Moderate | 1 | [
[
[
663,
24,
712
]
],
[
[
663,
24,
50
],
[
50,
40,
712
]
],
[
[
663,
25,
914
],
[
914,
24,
712
]
],
[
[
663,
7,
7720
],
[
7720,
45,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
],
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine (Compound) resembles Olsalazine (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Diflunisal and Diflunisal may cause a moderate interaction that could exac... |
DB00637 | DB11901 | 1,557 | 913 | [
"DDInter128",
"DDInter107"
] | Astemizole | Apalutamide | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1557,
24,
913
]
],
[
[
1557,
23,
112
],
[
112,
23,
913
]
],
[
[
1557,
64,
600
],
[
600,
24,
913
]
],
[
[
1557,
24,
28
],
[
28,
2... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Astemizole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Astemizole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Astemizole may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may c... |
DB00398 | DB06595 | 79 | 1,491 | [
"DDInter1702",
"DDInter1214"
] | Sorafenib | Midostaurin | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
79,
24,
1491
]
],
[
[
79,
23,
1135
],
[
1135,
62,
1491
]
],
[
[
79,
23,
112
],
[
112,
23,
1491
]
],
[
[
79,
24,
888
],
[
888,
24... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Sorafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Sorafenib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Sorafenib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazol... |
DB01064 | DB01599 | 1,148 | 1,232 | [
"DDInter987",
"DDInter1523"
] | Isoprenaline | Probucol | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Moderate | 1 | [
[
[
1148,
24,
1232
]
],
[
[
1148,
63,
1555
],
[
1555,
24,
1232
]
],
[
[
1148,
24,
927
],
[
927,
63,
1232
]
],
[
[
1148,
24,
77
],
[
77,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Probucol"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
],
[... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Probucol
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and E... |
DB00092 | DB00270 | 58 | 1,428 | [
"DDInter40",
"DDInter993"
] | Alefacept | Isradipine | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Moderate | 1 | [
[
[
58,
24,
1428
]
],
[
[
58,
24,
376
],
[
376,
40,
1428
]
],
[
[
58,
24,
854
],
[
854,
1,
1428
]
],
[
[
58,
24,
467
],
[
467,
62,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) resembles Isradipine (Compound)
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Nimodipine and Nimodipine (Compound) resembles Isradipine (Compound)
Al... |
DB09498 | DB16582 | 810 | 899 | [
"DDInter1715",
"DDInter1080"
] | Strontium chloride Sr-89 | Lisocabtagene maraleucel | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Lisocabtagene maraleucel is a chimeric antigen receptor (CAR) T-cell therapy, similar to [brexucabtagene autoleucel] and [axicabtagene ciloleucel].[A228493,L31588] Lisocabtagene maraleucel is a genetically modified autologous T-cell therapy that targets CD19, the B-lymphocyte surface antigen B4. CAR T-cell therapy has ... | Moderate | 1 | [
[
[
810,
24,
899
]
],
[
[
810,
63,
869
],
[
869,
24,
899
]
],
[
[
810,
24,
738
],
[
738,
24,
899
]
],
[
[
810,
24,
676
],
[
676,
25,... | [
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisocabtagene maraleucel"
]
],
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken wit... | Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Lisocabtagene maraleucel
Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseas... |
DB00556 | DB06595 | 1,262 | 1,491 | [
"DDInter1429",
"DDInter1214"
] | Perflutren | Midostaurin | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
1262,
24,
1491
]
],
[
[
1262,
23,
112
],
[
112,
23,
1491
]
],
[
[
1262,
24,
888
],
[
888,
24,
1491
]
],
[
[
1262,
24,
657
],
[
657,
... | [
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Perflutren",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Perflutren may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Perflutren may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamo... |
DB01176 | DB01242 | 537 | 1,237 | [
"DDInter453",
"DDInter410"
] | Cyclizine | Clomipramine | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
537,
24,
1237
]
],
[
[
537,
63,
684
],
[
684,
1,
1237
]
],
[
[
537,
1,
1321
],
[
1321,
40,
1237
]
],
[
[
537,
63,
902
],
[
902,
... | [
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
],
[
... | Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Cyclizine (Compound) resembles Prochlorperazine (Compound) and Prochlorperazine (Compound) resembles Clomipramine (Compound)
Cyclizine may cause a moderate... |
DB00365 | DB00619 | 839 | 1,419 | [
"DDInter842",
"DDInter909"
] | Grepafloxacin | Imatinib | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
839,
24,
1419
]
],
[
[
839,
23,
222
],
[
222,
62,
1419
]
],
[
[
839,
62,
1101
],
[
1101,
23,
1419
]
],
[
[
839,
24,
309
],
[
309,
... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
[... | Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Imatinib
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexaro... |
DB04908 | DB06228 | 1,671 | 792 | [
"DDInter741",
"DDInter1609"
] | Flibanserin | Rivaroxaban | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
1671,
24,
792
]
],
[
[
1671,
63,
752
],
[
752,
24,
792
]
],
[
[
1671,
64,
597
],
[
597,
24,
792
]
],
[
[
1671,
25,
1593
],
[
1593,
... | [
[
[
"Flibanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Flibanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
],
[... | Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban
Flibanserin may lead to a major life threatening interaction when taken with Chloramphenicol and Chloramphenic... |
DB00705 | DB12130 | 441 | 1,017 | [
"DDInter496",
"DDInter1094"
] | Delavirdine | Lorlatinib | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Major | 2 | [
[
[
441,
25,
1017
]
],
[
[
441,
63,
608
],
[
608,
23,
1017
]
],
[
[
441,
64,
175
],
[
175,
24,
1017
]
],
[
[
441,
25,
976
],
[
976,
... | [
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
"Lidocaine... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Delavirdine may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone may ca... |
DB00196 | DB01126 | 600 | 1,260 | [
"DDInter743",
"DDInter611"
] | Fluconazole | Dutasteride | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestos... | Moderate | 1 | [
[
[
600,
24,
1260
]
],
[
[
600,
24,
284
],
[
284,
40,
1260
]
],
[
[
600,
6,
7524
],
[
7524,
45,
1260
]
],
[
[
600,
21,
29023
],
[
29023,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dutasteride"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Finasteride"
],
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Finasteride and Finasteride (Compound) resembles Dutasteride (Compound)
Fluconazole (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Dutasteride (Compound)
Fluconazole (Compound) causes Neoplasm malignant (Side Effec... |
DB00470 | DB01612 | 530 | 1,637 | [
"DDInter601",
"DDInter92"
] | Dronabinol | Amyl Nitrite | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
530,
24,
1637
]
],
[
[
530,
24,
946
],
[
946,
24,
1637
]
],
[
[
530,
24,
180
],
[
180,
63,
1637
]
],
[
[
530,
63,
210
],
[
210,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Buspirone"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Buspirone and Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine and Olice... |
DB06792 | DB11943 | 1,606 | 255 | [
"DDInter1023",
"DDInter495"
] | Lanthanum carbonate | Delafloxacin | Lanthanum carbonate is a phosphate binder commonly used in clinical practice. It is marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals. It is the largest of all pills filled in community pharmacies. Sometimes patients forget that Fosrenol is not swallowed whole, but instead should be chewed. This has led... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Moderate | 1 | [
[
[
1606,
24,
255
]
],
[
[
1606,
63,
1596
],
[
1596,
24,
255
]
],
[
[
1606,
24,
428
],
[
428,
63,
255
]
],
[
[
1606,
63,
1596
],
[
1596,
... | [
[
[
"Lanthanum carbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delafloxacin"
]
],
[
[
"Lanthanum carbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
... | Lanthanum carbonate may cause a moderate interaction that could exacerbate diseases when taken with Iron and Iron may cause a moderate interaction that could exacerbate diseases when taken with Delafloxacin
Lanthanum carbonate may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumar... |
DB00552 | DB01177 | 1,238 | 77 | [
"DDInter1425",
"DDInter904"
] | Pentostatin | Idarubicin | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1238,
24,
77
]
],
[
[
1238,
5,
11555
],
[
11555,
44,
77
]
],
[
[
1238,
21,
28931
],
[
28931,
60,
77
]
],
[
[
1238,
23,
646
],
[
646,
... | [
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Pentostatin",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Dise... | Pentostatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Idarubicin (Compound)
Pentostatin (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Idarubicin (Compound)
Pentostatin may cause a minor interaction that can limit clinical effec... |
DB00277 | DB09080 | 1,031 | 144 | [
"DDInter1791",
"DDInter1331"
] | Theophylline | Olodaterol | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
1031,
24,
144
]
],
[
[
1031,
24,
956
],
[
956,
24,
144
]
],
[
[
1031,
64,
534
],
[
534,
24,
144
]
],
[
[
1031,
25,
1592
],
[
1592,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norfloxacin"
],
... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Theophylline may lead to a major life threatening interaction when taken with Tramadol and Tramadol may caus... |
DB00390 | DB05294 | 1,252 | 1,069 | [
"DDInter554",
"DDInter1917"
] | Digoxin | Vandetanib | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Moderate | 1 | [
[
[
1252,
24,
1069
]
],
[
[
1252,
6,
8374
],
[
8374,
45,
1069
]
],
[
[
1252,
7,
2192
],
[
2192,
45,
1069
]
],
[
[
1252,
21,
28921
],
[
289... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vandetanib"
]
],
[
[
"Digoxin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Digoxin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vandetanib (Compound)
Digoxin (Compound) upregulates EGFR (Gene) and EGFR (Gene) is bound by Vandetanib (Compound)
Digoxin (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Vandetanib (Compound)
Digoxin may cause a mod... |
DB00030 | DB00598 | 1,685 | 1,523 | [
"DDInter934",
"DDInter1013"
] | Insulin human | Labetalol | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Moderate | 1 | [
[
[
1685,
24,
1523
]
],
[
[
1685,
24,
532
],
[
532,
1,
1523
]
],
[
[
1685,
24,
1148
],
[
1148,
63,
1523
]
],
[
[
1685,
24,
1152
],
[
1152,... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dobutamine"
],
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Dobutamine and Dobutamine (Compound) resembles Labetalol (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction t... |
DB00792 | DB01114 | 832 | 272 | [
"DDInter1878",
"DDInter362"
] | Tripelennamine | Chlorpheniramine | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
832,
35,
272
]
],
[
[
832,
35,
358
],
[
358,
63,
272
]
],
[
[
832,
1,
11775
],
[
11775,
40,
272
]
],
[
[
832,
24,
1237
],
[
1237,
... | [
[
[
"Tripelennamine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Tripelennamine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a modera... | Tripelennamine (Compound) resembles Chlorpheniramine (Compound) and
Tripelennamine (Compound) resembles Orphenadrine (Compound) and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases... |
DB01082 | DB13886 | 1,448 | 125 | [
"DDInter1713",
"DDInter870"
] | Streptomycin | Human cytomegalovirus immune globulin | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Cytomegalovirus immunoglobulin is obtained from pooled adult human plasma selected for high titers of antibody for cytomegalovirus (CMV). It contains purified immunoglobulin G (IgG) antibodies targeting cytomegalovirus (CMV)[FDA label]. Cytomegalovirus, a member of the herpes virus family, is ubiquitous the human popul... | Major | 2 | [
[
[
1448,
25,
125
]
],
[
[
1448,
63,
1512
],
[
1512,
25,
125
]
],
[
[
1448,
24,
712
],
[
712,
25,
125
]
],
[
[
1448,
64,
1481
],
[
1481,
... | [
[
[
"Streptomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Human cytomegalovirus immune globulin"
]
],
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"... | Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may lead to a major life threatening interaction when taken with Human cytomegalovirus immune globulin
Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Olsal... |
DB01129 | DB01583 | 379 | 624 | [
"DDInter1559",
"DDInter1075"
] | Rabeprazole | Liotrix | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal s... | Moderate | 1 | [
[
[
379,
24,
624
]
],
[
[
379,
63,
1152
],
[
1152,
1,
624
]
],
[
[
379,
63,
542
],
[
542,
40,
624
]
],
[
[
379,
21,
28898
],
[
28898,
... | [
[
[
"Rabeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
]
],
[
[
"Rabeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liothyronine"
],
[
... | Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine (Compound) resembles Liotrix (Compound)
Rabeprazole may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxine and Levothyroxine (Compound) resembles Liotrix (Comp... |
DB13007 | DB15091 | 1,060 | 676 | [
"DDInter642",
"DDInter1901"
] | Enfortumab vedotin | Upadacitinib | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1060,
25,
676
]
],
[
[
1060,
63,
1430
],
[
1430,
24,
676
]
],
[
[
1060,
63,
1184
],
[
1184,
25,
676
]
],
[
[
1060,
64,
1064
],
[
1064,... | [
[
[
"Enfortumab vedotin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Enfortumab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
... | Enfortumab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Enfortumab vedotin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01098 | DB12026 | 14 | 791 | [
"DDInter1622",
"DDInter1950"
] | Rosuvastatin | Voxilaprevir | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most c... | Major | 2 | [
[
[
14,
25,
791
]
],
[
[
14,
24,
412
],
[
412,
24,
791
]
],
[
[
14,
25,
1510
],
[
1510,
24,
791
]
],
[
[
14,
24,
412
],
[
412,
64,
... | [
[
[
"Rosuvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voxilaprevir"
]
],
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
],
[
"Elu... | Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline and Eluxadoline may cause a moderate interaction that could exacerbate diseases when taken with Voxilaprevir
Rosuvastatin may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunom... |
DB00491 | DB00841 | 127 | 532 | [
"DDInter1217",
"DDInter577"
] | Miglitol | Dobutamine | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. | Moderate | 1 | [
[
[
127,
24,
532
]
],
[
[
127,
24,
817
],
[
817,
40,
532
]
],
[
[
127,
24,
1052
],
[
1052,
1,
532
]
],
[
[
127,
21,
28722
],
[
28722,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dobutamine"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dopamine"
],
[
"D... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Dopamine and Dopamine (Compound) resembles Dobutamine (Compound)
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine and Ritodrine (Compound) resembles Dobutamine (Compound)
Miglitol (... |
DB00683 | DB01254 | 1,382 | 1,213 | [
"DDInter1212",
"DDInter484"
] | Midazolam | Dasatinib | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1382,
24,
1213
]
],
[
[
1382,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
1382,
18,
16974
],
[
16974,
57,
1213
]
],
[
[
1382,
21,
29291
],
[
... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Midazolam",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Midazolam (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Midazolam (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Dasatinib (Compound)
Midazolam (Compound) causes Muscular weakness (Side Effect) and Muscular weakness (Side Effect) is caused by Dasatinib (Comp... |
DB06081 | DB06754 | 1,046 | 707 | [
"DDInter286",
"DDInter471"
] | Caplacizumab | Danaparoid | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Major | 2 | [
[
[
1046,
25,
707
]
],
[
[
1046,
23,
944
],
[
944,
62,
707
]
],
[
[
1046,
25,
298
],
[
298,
63,
707
]
],
[
[
1046,
24,
1496
],
[
1496,
... | [
[
[
"Caplacizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
]
],
[
[
"Caplacizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile... | Caplacizumab may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Danaparoid
Caplacizumab may lead to a major life threatening interaction when taken with Protein C and Protein C may cause a mo... |
DB01254 | DB12364 | 1,213 | 1,421 | [
"DDInter484",
"DDInter200"
] | Dasatinib | Betrixaban | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
1213,
25,
1421
]
],
[
[
1213,
23,
944
],
[
944,
62,
1421
]
],
[
[
1213,
23,
539
],
[
539,
23,
1421
]
],
[
[
1213,
64,
1091
],
[
1091,
... | [
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Dasatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Dasatinib may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Betrixaban
Dasatinib may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause... |
DB00862 | DB11986 | 1,005 | 484 | [
"DDInter1918",
"DDInter648"
] | Vardenafil | Entrectinib | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1005,
24,
484
]
],
[
[
1005,
24,
112
],
[
112,
23,
484
]
],
[
[
1005,
24,
774
],
[
774,
24,
484
]
],
[
[
1005,
63,
1674
],
[
1674,
... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Degarelix and De... |
DB11834 | DB14881 | 1,303 | 180 | [
"DDInter849",
"DDInter1329"
] | Guselkumab | Oliceridine | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation. In clinical trials, guselkumab demonstrat... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
1303,
24,
180
]
],
[
[
1303,
63,
1184
],
[
1184,
24,
180
]
],
[
[
1303,
64,
375
],
[
375,
24,
180
]
],
[
[
1303,
64,
1011
],
[
1011,
... | [
[
[
"Guselkumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Guselkumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anakinra"
],
[
... | Guselkumab may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Guselkumab may lead to a major life threatening interaction when taken with Certolizumab pegol and Certolizumab peg... |
DB01225 | DB06754 | 500 | 707 | [
"DDInter645",
"DDInter471"
] | Enoxaparin | Danaparoid | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity t... | Major | 2 | [
[
[
500,
25,
707
]
],
[
[
500,
23,
944
],
[
944,
62,
707
]
],
[
[
500,
63,
863
],
[
863,
24,
707
]
],
[
[
500,
24,
298
],
[
298,
63,... | [
[
[
"Enoxaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danaparoid"
]
],
[
[
"Enoxaparin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Enoxaparin may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Danaparoid
Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Amiloride and Amiloride may... |
DB00798 | DB14761 | 1,132 | 242 | [
"DDInter815",
"DDInter1578"
] | Gentamicin | Remdesivir | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
1132,
24,
242
]
],
[
[
1132,
63,
1512
],
[
1512,
24,
242
]
],
[
[
1132,
24,
361
],
[
361,
24,
242
]
],
[
[
1132,
25,
629
],
[
629,
... | [
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
],
[
... | Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neomycin... |
DB00358 | DB06414 | 1,010 | 655 | [
"DDInter1140",
"DDInter703"
] | Mefloquine | Etravirine | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
1010,
24,
655
]
],
[
[
1010,
24,
786
],
[
786,
40,
655
]
],
[
[
1010,
6,
4973
],
[
4973,
45,
655
]
],
[
[
1010,
21,
28723
],
[
28723,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Rilpivirine and Rilpivirine (Compound) resembles Etravirine (Compound)
Mefloquine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Etravirine (Compound)
Mefloquine (Compound) causes Malnutrition (Side Effect) and Malnut... |
DB00346 | DB01110 | 472 | 86 | [
"DDInter44",
"DDInter1209"
] | Alfuzosin | Miconazole | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
472,
24,
86
]
],
[
[
472,
6,
3958
],
[
3958,
45,
86
]
],
[
[
472,
21,
29122
],
[
29122,
60,
86
]
],
[
[
472,
24,
455
],
[
455,
2... | [
[
[
"Alfuzosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Alfuzosin",
"{u} (Compound) binds {v} (Gene)",
"KCNH2"
],
[
"KCNH2",
"{u} (Gene) is bound by {v} (Compound)",
... | Alfuzosin (Compound) binds KCNH2 (Gene) and KCNH2 (Gene) is bound by Miconazole (Compound)
Alfuzosin (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Miconazole (Compound)
Alfuzosin may cause a moderate interaction that could exacerbate diseases when taken with Sa... |
DB01001 | DB13139 | 688 | 1,032 | [
"DDInter1632",
"DDInter1063"
] | Salbutamol | Levosalbutamol | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
688,
24,
1032
]
],
[
[
688,
62,
218
],
[
218,
23,
1032
]
],
[
[
688,
23,
1220
],
[
1220,
23,
1032
]
],
[
[
688,
24,
1618
],
[
1618,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Salbutamol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Beclomethasone dipropiona... | Salbutamol may cause a minor interaction that can limit clinical effects when taken with Beclomethasone dipropionate and Beclomethasone dipropionate may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Salbutamol may cause a minor interaction that can limit clinical effects when ... |
DB01142 | DB09278 | 1,264 | 852 | [
"DDInter593",
"DDInter24"
] | Doxepin | Activated charcoal | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity... | Moderate | 1 | [
[
[
1264,
24,
852
]
],
[
[
1264,
74,
21
],
[
21,
24,
852
]
],
[
[
1264,
63,
1411
],
[
1411,
24,
852
]
],
[
[
1264,
24,
697
],
[
697,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Activated charcoal"
]
],
[
[
"Doxepin",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken... | Doxepin (Compound) resembles Amitriptyline (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Activated charcoal
Doxepin may cause a moderate interaction th... |
DB01246 | DB13913 | 820 | 1,536 | [
"DDInter45",
"DDInter175"
] | Alimemazine | Belladonna | A phenothiazine derivative that is used as an antipruritic. | Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family _Solanaceae_. Its roots, leaves and fruits contain , , and mostly, . These alkaloids are naturally-occurring muscarinic antagonists. is a non-selective muscarinic antagonist that is mainly used as ... | Moderate | 1 | [
[
[
820,
24,
1536
]
],
[
[
820,
24,
849
],
[
849,
24,
1536
]
],
[
[
820,
63,
128
],
[
128,
24,
1536
]
],
[
[
820,
74,
1376
],
[
1376,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belladonna"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Belladonna
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine ... |
DB06212 | DB09122 | 165 | 1,613 | [
"DDInter1833",
"DDInter1409"
] | Tolvaptan | Peginterferon beta-1a | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
165,
24,
1613
]
],
[
[
165,
63,
600
],
[
600,
24,
1613
]
],
[
[
165,
24,
351
],
[
351,
63,
1613
]
],
[
[
165,
24,
1250
],
[
1250,
... | [
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
]... | Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib... |
DB01132 | DB06414 | 1,130 | 655 | [
"DDInter1472",
"DDInter703"
] | Pioglitazone | Etravirine | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
1130,
24,
655
]
],
[
[
1130,
6,
6017
],
[
6017,
45,
655
]
],
[
[
1130,
21,
28723
],
[
28723,
60,
655
]
],
[
[
1130,
63,
1101
],
[
1101... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Pioglitazone",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compoun... | Pioglitazone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Etravirine (Compound)
Pioglitazone (Compound) causes Malnutrition (Side Effect) and Malnutrition (Side Effect) is caused by Etravirine (Compound)
Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Bexarot... |
DB00295 | DB09117 | 475 | 957 | [
"DDInter1244",
"DDInter1391"
] | Morphine | Paraldehyde | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Paraldehyde was initially introduced into medical practice in the United Kingdom in 1882 by the Italian physician Vincenzo Cervello. It is classified as a central nervous system (CNS) depressant and has also been found to be an effective anticonvulsant, hypnotic and sedative agent due to its CNS depressant properties. ... | Major | 2 | [
[
[
475,
25,
957
]
],
[
[
475,
24,
1264
],
[
1264,
24,
957
]
],
[
[
475,
63,
1648
],
[
1648,
24,
957
]
],
[
[
475,
25,
593
],
[
593,
... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paraldehyde"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
"Doxepin",
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Paraldehyde
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin ma... |
DB00023 | DB09043 | 305 | 135 | [
"DDInter127",
"DDInter36"
] | Asparaginase Escherichia coli | Albiglutide | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
305,
24,
135
]
],
[
[
305,
24,
126
],
[
126,
23,
135
]
],
[
[
305,
24,
1632
],
[
1632,
24,
135
]
],
[
[
305,
24,
1019
],
[
1019,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when... |
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