query_id stringlengths 1 4 | query stringlengths 26 249 | positive_passages listlengths 1 5 | negative_passages listlengths 16 20 |
|---|---|---|---|
346 | Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling. | [
{
"docid": "11902109",
"title": "Direct sensing of systemic and nutritional signals by hematopoietic progenitors in Drosophila",
"text": "The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in mammals, proliferate and diffe... | [
{
"docid": "17933691",
"title": "Characterization of adipocytes derived from fibro/adipogenic progenitors resident in human skeletal muscle",
"text": "A population of fibro/adipogenic but non-myogenic progenitors located between skeletal muscle fibers was recently discovered. The aim of this study was t... |
347 | Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed. | [
{
"docid": "11902109",
"title": "Direct sensing of systemic and nutritional signals by hematopoietic progenitors in Drosophila",
"text": "The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in mammals, proliferate and diffe... | [
{
"docid": "37699461",
"title": "Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells.",
"text": "Beta-cell replacement is considered to be the most promising approach for treatment of type 1 diabetes. Its application on a l... |
349 | Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population. | [
{
"docid": "13497630",
"title": "Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age",
"text": "Importance Despite lack of evidence of their utility, biomarkers of ovarian reserve are being promoted as potential markers of reproductive potential. Objec... | [
{
"docid": "11109043",
"title": "Cost-effectiveness of aromatase inhibitor co-treatment for controlled ovarian stimulation.",
"text": "BACKGROUND To compare the clinical results and the cost-effectiveness of using the aromatase inhibitor, letrozole, in conjunction with FSH and FSH alone for controlled o... |
351 | Distant CREs are important for transcriptional regulation. | [
{
"docid": "14658685",
"title": "Enhancer Evolution across 20 Mammalian Species",
"text": "The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promote... | [
{
"docid": "21622715",
"title": "Coupling cAMP signaling to transcription in the liver: pivotal role of CREB and CREM.",
"text": "Transcriptional factors binding to cAMP-responsive elements (CREs) in the promoters of various genes belong to the basic domain-leucine zipper superfamily and are composed of... |
352 | Distant CREs are less conserved among species. | [
{
"docid": "14658685",
"title": "Enhancer Evolution across 20 Mammalian Species",
"text": "The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promote... | [
{
"docid": "18855191",
"title": "Exploitative and Hierarchical Antagonism in a Cooperative Bacterium",
"text": "Social organisms that cooperate with some members of their own species, such as close relatives, may fail to cooperate with other genotypes of the same species. Such noncooperation may take th... |
355 | Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs. | [
{
"docid": "12800122",
"title": "Increased Cell Bond Tension Governs Cell Sorting at the Drosophila Anteroposterior Compartment Boundary",
"text": "Subdividing proliferating tissues into compartments is an evolutionarily conserved strategy of animal development [1-6]. Signals across boundaries between c... | [
{
"docid": "9646449",
"title": "Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila.",
"text": "The Drosophila gene eyeless (ey) encodes a transcription factor with both a paired domain and a homeodomain. It is homologous to the mouse Small eye (Pax-6) gene and to the Anir... |
356 | Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system. | [
{
"docid": "6144337",
"title": "AgDscam, a Hypervariable Immunoglobulin Domain-Containing Receptor of the Anopheles gambiae Innate Immune System ",
"text": "Activation of the insect innate immune system is dependent on a limited number of pattern recognition receptors (PRRs) capable of interac... | [
{
"docid": "2506153",
"title": "Invariant natural killer T cells: bridging innate and adaptive immunity",
"text": "Cells of the innate immune system interact with pathogens via conserved pattern-recognition receptors, whereas cells of the adaptive immune system recognize pathogens through diverse, antig... |
357 | During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks. | [
{
"docid": "18111172",
"title": "The fidelity of the ligation step determines how ends are resolved during Nonhomologous end joining",
"text": "Nonhomologous end joining (NHEJ) can effectively resolve chromosome breaks despite diverse end structures; however, it is unclear how the steps employed for res... | [
{
"docid": "20821402",
"title": "Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends.",
"text": "Nonhomologous end joining (NHEJ) is essential for efficient repair of chromosome breaks. However, the NHEJ ligation step is often obstructed by break-asso... |
358 | During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks. | [
{
"docid": "18111172",
"title": "The fidelity of the ligation step determines how ends are resolved during Nonhomologous end joining",
"text": "Nonhomologous end joining (NHEJ) can effectively resolve chromosome breaks despite diverse end structures; however, it is unclear how the steps employed for res... | [
{
"docid": "20821402",
"title": "Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends.",
"text": "Nonhomologous end joining (NHEJ) is essential for efficient repair of chromosome breaks. However, the NHEJ ligation step is often obstructed by break-asso... |
361 | During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells. | [
{
"docid": "38587347",
"title": "Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses.",
"text": "Humoral immune responses depend on B cells encountering antigen, interacting with helper T cells, proliferating and differentiating into low-affinity plasma cells ... | [
{
"docid": "34615397",
"title": "Human tuberculous granulomas induce peripheral lymphoid follicle-like structures to orchestrate local host defence in the lung.",
"text": "The human tuberculous granuloma provides the morphological basis for local immune processes central to the outcome of tuberculosis. ... |
363 | EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells. | [
{
"docid": "5386514",
"title": "Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors",
"text": "The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs), which present antigens from dying cancer cells to prime t... | [
{
"docid": "27567994",
"title": "CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens.",
"text": "The generation of tumor-directed cytotoxic T lymphocytes is considered crucial for the induction of antitumor immunity. To activate these CD8(+) T cells, a... |
364 | EGR2 is important to myelination of the peripheral nervous system. | [
{
"docid": "1550937",
"title": "The Transcription Factors Egr2 and Egr3 Are Essential for the Control of Inflammation and Antigen-Induced Proliferation of B and T Cells",
"text": "Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. However, the intrinsic mechanis... | [
{
"docid": "2601324",
"title": "Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity",
"text": "Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term axonal integrity. However, the underlying support mechanisms are not understood. Here w... |
365 | ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2. | [
{
"docid": "600437",
"title": "Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P",
"text": "VAP (VAPA and VAPB) is an evolutionarily conserved endoplasmic reticulum (ER)-anchored protein that helps generate tethers between the ER and other membr... | [
{
"docid": "11250124",
"title": "AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory.",
"text": "Synaptic vesicle recycling involves AP-2/clathrin-mediated endocytosis, but it is not known whether the endosomal pathway is also required. Mice deficient in the tissue-sp... |
366 | ERAP1 SNPs are epistatic to HLA alleles for ankylosing spondylitis. | [
{
"docid": "13956305",
"title": "Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1",
"text": "Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, ... | [
{
"docid": "97884",
"title": "The sacroiliac joint in the spondyloarthropathies.",
"text": "The term spondyloarthropathy (SpA) describes and defines a group of related inflammatory joint disease that share characteristic clinical features and a unique association with the major histocompatibility comple... |
367 | Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality. | [
{
"docid": "27099731",
"title": "Association Between Early Screening for Patent Ductus Arteriosus and In-Hospital Mortality Among Extremely Preterm Infants.",
"text": "IMPORTANCE There is currently no consensus for the screening and treatment of patent ductus arteriosus (PDA) in extremely preterm infant... | [
{
"docid": "9967265",
"title": "Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants.",
"text": "BACKGROUND Patent ductus arteriosus (PDA) with significant left to right shunt in preterm infants increases morbidity and mortality. Ea... |
368 | Early patent ductus ateriosus (PDA) screening increases in-hospital mortality. | [
{
"docid": "27099731",
"title": "Association Between Early Screening for Patent Ductus Arteriosus and In-Hospital Mortality Among Extremely Preterm Infants.",
"text": "IMPORTANCE There is currently no consensus for the screening and treatment of patent ductus arteriosus (PDA) in extremely preterm infant... | [
{
"docid": "9967265",
"title": "Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants.",
"text": "BACKGROUND Patent ductus arteriosus (PDA) with significant left to right shunt in preterm infants increases morbidity and mortality. Ea... |
369 | Ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generates induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently than other factor combinations. | [
{
"docid": "6826100",
"title": "The developmental potential of iPSCs is greatly influenced by reprogramming factor selection.",
"text": "Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4, and Myc (OSKM) into cells. Although iPSCs are pluripotent, they freq... | [
{
"docid": "9675944",
"title": "Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.",
"text": "Somatic cells can be induced into pluripotent stem cells (iPSCs) with a combination of four transcription factors, Oct4/Sox2/Klf4/c-Myc or Oct4/... |
370 | Egr2 regulates the homeostasis of B and T cells. | [
{
"docid": "1550937",
"title": "The Transcription Factors Egr2 and Egr3 Are Essential for the Control of Inflammation and Antigen-Induced Proliferation of B and T Cells",
"text": "Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. However, the intrinsic mechanis... | [
{
"docid": "7399084",
"title": "Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance",
"text": "T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells resulting from lack of regulatory T cells or an inability to shut down immune r... |
371 | Egr3 regulates the homeostasis of B and T cells. | [
{
"docid": "1550937",
"title": "The Transcription Factors Egr2 and Egr3 Are Essential for the Control of Inflammation and Antigen-Induced Proliferation of B and T Cells",
"text": "Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. However, the intrinsic mechanis... | [
{
"docid": "7399084",
"title": "Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance",
"text": "T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells resulting from lack of regulatory T cells or an inability to shut down immune r... |
372 | Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates. | [
{
"docid": "24922825",
"title": "A chikungunya fever vaccine utilizing an insect-specific virus platform",
"text": "Traditionally, vaccine development involves tradeoffs between immunogenicity and safety. Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety when co... | [
{
"docid": "8883846",
"title": "Antibody-Based HIV-1 Vaccines: Recent Developments and Future Directions",
"text": "The Global HIV Vaccine Enterprise convened a two-day workshop in May of 2007 to discuss humoral immune responses to HIV and approaches to design vaccines that induce viral neutralizing and... |
375 | Elevated cell-free mitochondrial DNA levels are associated with mortality. | [
{
"docid": "1522647",
"title": "Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation",
"text": "BACKGROUND Mitochondrial DNA (mtDNA) is a critical activator of inflammation and the innate immune system. However, mtDNA level has not been tested for its ... | [
{
"docid": "20459964",
"title": "Circulating mitochondrial DNA in serum of patients with granulomatosis with polyangiitis.",
"text": "Neutrophil is a key cell in pathophysiology of granulomatosis with polyangiitis. Recently, neutrophil extracellular traps were described in this disease. Mitochondrial DN... |
376 | Eliminating the last sporadic cases of malaria requires considerable funding. | [
{
"docid": "22401061",
"title": "Costs and financial feasibility of malaria elimination",
"text": "The marginal costs and benefits of converting malaria programmes from a control to an elimination goal are central to strategic decisions, but empirical evidence is scarce. We present a conceptual framewor... | [
{
"docid": "5710820",
"title": "The feasibility of malaria elimination in South Africa",
"text": "BACKGROUND Following the last major malaria epidemic in 2000, malaria incidence in South Africa has declined markedly. The decrease has been so emphatic that South Africa now meets the World Health Organiza... |
377 | Emodin forms hydrogen bonds with residues involved in PGAM1 substrate binding. | [
{
"docid": "18810195",
"title": "Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation",
"text": "How oncogenic signalling coordinates glycolysis and anabolic biosynthesis in cancer cells remains unclear. We recently reported that the glycolytic ... | [
{
"docid": "12225214",
"title": "Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase.",
"text": "Ubiquitination controls a broad range of cellular functions. The last step of the ubiquitination pathway is regulated by enzyme type 3 (E3) ubiquitin ligases. E3 enzymes are responsible for s... |
378 | Energy balance requires hypothalamic glutamate neurotransmission. | [
{
"docid": "45154987",
"title": "Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation.",
"text": "The melanocortin receptor 4 (MC4R) is a well-established mediator of body weight homeostasis. However, the neurotransmitter(s) that mediate MC4R function rema... | [
{
"docid": "14782049",
"title": "In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus.",
"text": "The cognitive deficits observed in children with cyanotic congenital heart disease suggest involvement of the developing hippocampus. Chronic postnatal hypoxia pr... |
379 | Enhanced early production of inflammatory chemokines damages viral control in the lung. | [
{
"docid": "19005293",
"title": "Memory CD4+ T cells induce innate responses independently of pathogen",
"text": "Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses. We asked whether the adaptive immune system can also affect the ... | [
{
"docid": "26068103",
"title": "Dual role of interleukin-10 in the regulation of respiratory syncitial virus (RSV)-induced lung inflammation.",
"text": "RSV lower respiratory tract infections (LRTI) are among the most common diseases necessitating hospital admission in children. In addition to causing ... |
381 | Environmental factors can influence the development of breast cancer. | [
{
"docid": "18340282",
"title": "Gene–environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study",
"text": "BACKGROUND Information is scarce about the combined effects on breast cancer incidence of low-penetrance genetic susceptibility polymorphisms and ... | [
{
"docid": "5222182",
"title": "Predictors of mammographic density: insights gained from a novel regression analysis of a twin study.",
"text": "Understanding which factors influence mammographically dense and nondense areas is important because percent mammographic density adjusted for age is a strong,... |
382 | Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system. | [
{
"docid": "11659421",
"title": "Human iPSC-based modeling of late-onset disease via progerin-induced aging.",
"text": "Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset di... | [
{
"docid": "4709641",
"title": "Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector",
"text": "Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a p... |
383 | Epidemiological disease burden from noncommunicable diseases is more prevalent in high economic settings. | [
{
"docid": "13770184",
"title": "Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015",
"text": "BACKGROUND The Global Burden of... | [
{
"docid": "51972698",
"title": "Adapting the WHO package of essential noncommunicable disease interventions, Samoa",
"text": "Problem Samoa has been struggling to address the burden of noncommunicable diseases at the health system, community and individual levels. Approach The World Health Organizat... |
389 | Ethanol stress increases the expression of IBP in bacteria. | [
{
"docid": "1148122",
"title": "Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli",
"text": "Understanding the genetic basis of adaptation is a central problem in biology. However, revealing the underlying molecular mechanisms has been challenging as changes i... | [
{
"docid": "21602220",
"title": "Complex physiology and compound stress responses during fermentation of alkali-pretreated corn stover hydrolysate by an Escherichia coli ethanologen.",
"text": "The physiology of ethanologenic Escherichia coli grown anaerobically in alkali-pretreated plant hydrolysates i... |
390 | Ethanol stress increases the expression of PSP in bacteria. | [
{
"docid": "1148122",
"title": "Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli",
"text": "Understanding the genetic basis of adaptation is a central problem in biology. However, revealing the underlying molecular mechanisms has been challenging as changes i... | [
{
"docid": "21602220",
"title": "Complex physiology and compound stress responses during fermentation of alkali-pretreated corn stover hydrolysate by an Escherichia coli ethanologen.",
"text": "The physiology of ethanologenic Escherichia coli grown anaerobically in alkali-pretreated plant hydrolysates i... |
391 | Ethanol stress increases the expression of SRL in bacteria. | [
{
"docid": "1148122",
"title": "Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli",
"text": "Understanding the genetic basis of adaptation is a central problem in biology. However, revealing the underlying molecular mechanisms has been challenging as changes i... | [
{
"docid": "21602220",
"title": "Complex physiology and compound stress responses during fermentation of alkali-pretreated corn stover hydrolysate by an Escherichia coli ethanologen.",
"text": "The physiology of ethanologenic Escherichia coli grown anaerobically in alkali-pretreated plant hydrolysates i... |
392 | Ethanol stress lowers the expression of PSP in bacteria. | [
{
"docid": "1148122",
"title": "Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli",
"text": "Understanding the genetic basis of adaptation is a central problem in biology. However, revealing the underlying molecular mechanisms has been challenging as changes i... | [
{
"docid": "21602220",
"title": "Complex physiology and compound stress responses during fermentation of alkali-pretreated corn stover hydrolysate by an Escherichia coli ethanologen.",
"text": "The physiology of ethanologenic Escherichia coli grown anaerobically in alkali-pretreated plant hydrolysates i... |
393 | Ethanol stress reduces the expression of SRL in bacteria. | [
{
"docid": "1148122",
"title": "Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli",
"text": "Understanding the genetic basis of adaptation is a central problem in biology. However, revealing the underlying molecular mechanisms has been challenging as changes i... | [
{
"docid": "21602220",
"title": "Complex physiology and compound stress responses during fermentation of alkali-pretreated corn stover hydrolysate by an Escherichia coli ethanologen.",
"text": "The physiology of ethanologenic Escherichia coli grown anaerobically in alkali-pretreated plant hydrolysates i... |
394 | Excess gestational weight gain is associated with obesity-related pregnancy outcomes. | [
{
"docid": "11360768",
"title": "Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence",
"text": "OBJECTIVE To evaluate the effects of dietary and lifestyle interventions in pregnancy on maternal and fetal weight and to quantify the effects... | [
{
"docid": "70455704",
"title": "Weight gain during pregnancy: reexamining the guidelines.",
"text": "As women of childbearing age have become heavier, the trade-off between maternal and child health created by variation in gestational weight gain has become more difficult to reconcile. Weight Gain Duri... |
396 | Exercise increases cancer mortality rates among Chinese citizens. | [
{
"docid": "1456068",
"title": "Combined Impact of Lifestyle-Related Factors on Total and Cause-Specific Mortality among Chinese Women: Prospective Cohort Study",
"text": "BACKGROUND Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-relat... | [
{
"docid": "24918110",
"title": "Exercise capacity and body mass as predictors of mortality among male veterans with type 2 diabetes.",
"text": "OBJECTIVE To demonstrate the relation of exercise capacity and BMI to mortality in a population of male veterans with type 2 diabetes. RESEARCH DESIGN AND M... |
397 | Exercise reduces cancer mortality rates among Chinese citizens. | [
{
"docid": "1456068",
"title": "Combined Impact of Lifestyle-Related Factors on Total and Cause-Specific Mortality among Chinese Women: Prospective Cohort Study",
"text": "BACKGROUND Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-relat... | [
{
"docid": "10209731",
"title": "Cardiovascular diseases in Chinese, Malays, and Indians in Singapore. I. Differences in mortality.",
"text": "STUDY OBJECTIVE The aim of the study was to analyse differences in mortality from the main cardiovascular diseases (ischaemic heart disease, hypertensive disease... |
398 | Exhaustion of B cells contributes to poor Ab response in HIV-infected individuals. | [
{
"docid": "8883846",
"title": "Antibody-Based HIV-1 Vaccines: Recent Developments and Future Directions",
"text": "The Global HIV Vaccine Enterprise convened a two-day workshop in May of 2007 to discuss humoral immune responses to HIV and approaches to design vaccines that induce viral neutralizing and... | [
{
"docid": "20261352",
"title": "Decoupling activation and exhaustion of B cells in spontaneous controllers of HIV infection.",
"text": "OBJECTIVE To define the impact of chronic viremia and associated immune activation on B-cell exhaustion in HIV infection. \n DESIGN Progressive HIV infection is mark... |
400 | Exposure to fine particulate air pollution is unrelated to anxiety prevalence. | [
{
"docid": "791050",
"title": "The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study",
"text": "OBJECTIVE To determine whether higher past exposure to particulate air pollution is associated with prevalent high symptoms of anxiety. \n DE... | [
{
"docid": "471921",
"title": "Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association.",
"text": "Air pollution is a heterogeneous, complex mixture of gases, liquids, and particulate ... |
401 | Expression of MSX2 is induced 3 hours after the addition of BMP4, which is earlier than T and CDX2. | [
{
"docid": "5633876",
"title": "BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages",
"text": "BMP is thought to induce hESC differentiation toward multiple lineages including mesoderm and trophoblast. The BMP-induce... | [
{
"docid": "57783564",
"title": "CDX2 inhibits the proliferation and tumor formation of colon cancer cells by suppressing Wnt/β-catenin signaling via transactivation of GSK-3β and Axin2 expression",
"text": "Caudal-related homeobox transcription factor 2 (CDX2), an intestine-specific nuclear transcripti... |
403 | Expression of oncolytic virus antigens as peptides makes relapse more likely. | [
{
"docid": "1921218",
"title": "Detecting and targeting tumor relapse by its resistance to innate effectors at early recurrence",
"text": "Tumor recurrence represents a major clinical challenge. Our data show that emergent recurrent tumors acquire a phenotype radically different from that of their origi... | [
{
"docid": "21150010",
"title": "Treatment with cyclooxygenase-2 inhibitors enables repeated administration of vaccinia virus for control of ovarian cancer.",
"text": "Metastatic ovarian cancer is the leading cause of death among women with gynecologic malignancies in the United States. The lack of effe... |
404 | Expression of oncolytic virus antigens as peptides permits additional protection against relapse. | [
{
"docid": "1921218",
"title": "Detecting and targeting tumor relapse by its resistance to innate effectors at early recurrence",
"text": "Tumor recurrence represents a major clinical challenge. Our data show that emergent recurrent tumors acquire a phenotype radically different from that of their origi... | [
{
"docid": "9278263",
"title": "MHC class I antigen presentation: learning from viral evasion strategies",
"text": "The cell surface display of peptides by MHC class I molecules to lymphocytes provides the host with an important surveillance mechanism to protect against invading pathogens. However, in t... |
406 | F4/80+ macrophages regulate mature osteoblast maintenance. | [
{
"docid": "6796297",
"title": "PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis",
"text": "Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent study showed that a specific vessel subtype, strongly positive for CD31 and endomuc... | [
{
"docid": "7386360",
"title": "Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages.",
"text": "Infectious pathogens can selectively stimulate activation or suppression of T cells to facilitate their survival within humans. In this s... |
407 | FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process. | [
{
"docid": "9889151",
"title": "FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs.",
"text": "FACT, a heterodimer of Spt16 and Pob3, is an essential histone chaperone. We show that the H2A-H2B binding activity that is central to FACT function resides in short acidic reg... | [
{
"docid": "9451052",
"title": "Stepwise Histone Replacement by SWR1 Requires Dual Activation with Histone H2A.Z and Canonical Nucleosome",
"text": "Histone variant H2A.Z-containing nucleosomes are incorporated at most eukaryotic promoters. This incorporation is mediated by the conserved SWR1 complex, w... |
413 | Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia. | [
{
"docid": "6309659",
"title": "Reproductive period and risk of dementia in postmenopausal women.",
"text": "CONTEXT Exogenous estrogen use may lower risk of dementia in postmenopausal women. A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized bu... | [
{
"docid": "12443371",
"title": "Apolipoprotein E genotype and concussion in college athletes.",
"text": "OBJECTIVE To evaluate the association between apolipoprotein E (APOE) polymorphisms (E2, C/T Arg158Cys; E4, T/C Cys112Arg; and promoter, g-219t) and the history of concussion in college athletes. We... |
414 | Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease. | [
{
"docid": "6309659",
"title": "Reproductive period and risk of dementia in postmenopausal women.",
"text": "CONTEXT Exogenous estrogen use may lower risk of dementia in postmenopausal women. A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized bu... | [
{
"docid": "4709641",
"title": "Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector",
"text": "Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a p... |
416 | Female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period. | [
{
"docid": "6309659",
"title": "Reproductive period and risk of dementia in postmenopausal women.",
"text": "CONTEXT Exogenous estrogen use may lower risk of dementia in postmenopausal women. A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized bu... | [
{
"docid": "12443371",
"title": "Apolipoprotein E genotype and concussion in college athletes.",
"text": "OBJECTIVE To evaluate the association between apolipoprotein E (APOE) polymorphisms (E2, C/T Arg158Cys; E4, T/C Cys112Arg; and promoter, g-219t) and the history of concussion in college athletes. We... |
417 | Female carriers of the Apolipoprotein E4 (APOE4) allele have shorter lifetime exposure to estrogen due to a decreased reproductive period. | [
{
"docid": "6309659",
"title": "Reproductive period and risk of dementia in postmenopausal women.",
"text": "CONTEXT Exogenous estrogen use may lower risk of dementia in postmenopausal women. A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized bu... | [
{
"docid": "12443371",
"title": "Apolipoprotein E genotype and concussion in college athletes.",
"text": "OBJECTIVE To evaluate the association between apolipoprotein E (APOE) polymorphisms (E2, C/T Arg158Cys; E4, T/C Cys112Arg; and promoter, g-219t) and the history of concussion in college athletes. We... |
418 | Fibroblast Growth Factor is a ligand which signals through receptor tyrosine kinases. | [
{
"docid": "16660256",
"title": "Sprouty1 Regulates Reversible Quiescence of a Self-Renewing Adult Muscle Stem Cell Pool during Regeneration",
"text": "Satellite cells are skeletal muscle stem cells capable of self-renewal and differentiation after transplantation, but whether they contribute to endogen... | [
{
"docid": "12785130",
"title": "The regulation of N-methyl-D-aspartate receptors by Src kinase.",
"text": "Src family kinases (SFKs) play critical roles in the regulation of many cellular functions by growth factors, G-protein-coupled receptors and ligand-gated ion channels. Recent data have shown that... |
420 | Fibroblast growth factor 21 protects against atherosclerosis by modulating adiponectin and SREBP2 levels. | [
{
"docid": "9315213",
"title": "Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice",
"text": "BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glu... | [
{
"docid": "1840993",
"title": "LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys",
"text": "Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator that represents a promising target for the treatment of several metabolic diseases. Administration of re... |
422 | Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules. | [
{
"docid": "11172205",
"title": "Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo",
"text": "A solid tumor is an organ composed of cancer and host cells embedded in an extracellular matrix and nourished by blood vessels. A prerequisite to understanding tumor pathophys... | [
{
"docid": "1065627",
"title": "Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors.",
"text": "Stiffness is a biophysical property of the extracellular matrix that modulates cellular functions, including proliferat... |
423 | Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia. | [
{
"docid": "8595678",
"title": "Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials",
"text": "BACKGROUND The MTHFR 677C→T polymorphism has been associated with raised homocyst... | [
{
"docid": "42441846",
"title": "Gene--nutrition interactions in coronary artery disease: correlation between the MTHFR C677T polymorphism and folate and homocysteine status in a Korean population.",
"text": "INTRODUCTION Elevated plasma total homocysteine is a major risk for coronary artery disease (CA... |
425 | For every 1,000 children with cerebral palsy, more than 300 of them are premature or underweight at birth. | [
{
"docid": "33257464",
"title": "Changes in the prevalence of cerebral palsy for children born very prematurely within a population-based program over 30 years.",
"text": "CONTEXT Although cerebral palsy (CP) among extremely premature infants has been reported as a major morbidity outcome, there are dif... | [
{
"docid": "20645335",
"title": "Neurodevelopmental Outcome After a Single Course of Antenatal Steroids in Children Born Preterm: A Systematic Review and Meta-analysis.",
"text": "OBJECTIVE To systematically review and integrate data on the neurodevelopmental outcome of children after administration of ... |
426 | Forkhead 0 (fox0) transcription factors are involved in apoptosis. | [
{
"docid": "16728949",
"title": "Cell Stem Cell Review FoxO Transcription Factors and Stem Cell Homeostasis: Insights from the Hematopoietic System",
"text": "The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, st... | [
{
"docid": "28937856",
"title": "Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.",
"text": "The Sir2 deacetylase modulates organismal life-span in various species. However, the molecular mechanisms by which Sir2 increases longevity are largely unknown. We show that in... |
428 | Forkhead 0 (fox0) transcription factors are involved in cellular differentiation. | [
{
"docid": "16728949",
"title": "Cell Stem Cell Review FoxO Transcription Factors and Stem Cell Homeostasis: Insights from the Hematopoietic System",
"text": "The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, st... | [
{
"docid": "4418070",
"title": "Novel Foxo1-dependent transcriptional programs control Treg cell function",
"text": "Regulatory T (Treg) cells, characterized by expression of the transcription factor forkhead box P3 (Foxp3), maintain immune homeostasis by suppressing self-destructive immune responses. F... |
429 | Formation of N-terminal pyroglutamate by glutamine cyclase (GC) competes with NTAQ1 for Nt-Gln substrates. | [
{
"docid": "36540079",
"title": "Glutamine-specific N-terminal amidase, a component of the N-end rule pathway.",
"text": "Deamidation of N-terminal Gln by Nt(Q)-amidase, an N-terminal amidohydrolase, is a part of the N-end rule pathway of protein degradation. We detected the activity of Nt(Q)-amidase, t... | [
{
"docid": "10169908",
"title": "SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.",
"text": "PURPOSE We have previously identified solute-linked carrier family A1 member 5 (SLC1A5) as an overexpressed protein in a shotgun proteomic analysis of stage I non-small cell... |
430 | FoxO3a activation in neuronal death is inhibited by reactive oxygen species (ROS). | [
{
"docid": "28937856",
"title": "Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.",
"text": "The Sir2 deacetylase modulates organismal life-span in various species. However, the molecular mechanisms by which Sir2 increases longevity are largely unknown. We show that in... | [
{
"docid": "36838958",
"title": "Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species.",
"text": "Uncoupling protein 1 (Ucp1), which is localized in the mitochondrial inner membrane of mammalian brown adipose tissue (BAT), generates heat by uncoupling oxidative p... |
432 | Foxk2 regulates autophagy genes in muscle cells and fibroblast cells. | [
{
"docid": "8002887",
"title": "Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs",
"text": "Autophagy is the primary catabolic process triggered in response to starvation. Although autophagic regulation within the cytosolic compartment is well established, it is ... | [
{
"docid": "31882215",
"title": "Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming",
"text": "We describe robust induction of autophagy during the reprogramming of mouse fibroblasts to induced pluripotent stem cells by four reprogramming factors (Sox2, Oct4, Klf4 and c-Myc... |
434 | Foxp3 enables the expression of transcriptional regulators implicated in memory T cell development. | [
{
"docid": "9500590",
"title": "Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict",
"text": "Regulatory T (Treg) cells, whose differentiation and function are controlled by X chromosome-encoded transcription factor Foxp3, are generated in the thymus (tTr... | [
{
"docid": "41877386",
"title": "Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells.",
"text": "CD4(+)CD25(+) regulatory T cells (T regs) play a major role in the maintenance of self-tolerance and immune suppression, although the m... |
435 | Foxp3 represses the expression of transcriptional regulators implicated in memory T cell development. | [
{
"docid": "9500590",
"title": "Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict",
"text": "Regulatory T (Treg) cells, whose differentiation and function are controlled by X chromosome-encoded transcription factor Foxp3, are generated in the thymus (tTr... | [
{
"docid": "10359591",
"title": "Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.",
"text": "Interleukin(IL)-2 and inflammation regulate effector and memory cytolytic T-lymphocyte (CTL) generation during infection. We... |
441 | G-CSF increases the expansion and infiltration of MDSCs into tumors. | [
{
"docid": "2014909",
"title": "Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation",
"text": "Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic cancer progression. MDSC regulation is widely variable even among patients harb... | [
{
"docid": "25726838",
"title": "IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells.",
"text": "The role of immune responses in tumor development is a central issue for tumor biology and immunology. IL-17 is an ... |
444 | GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells. | [
{
"docid": "10165258",
"title": "GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry.",
"text": "Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells. Approximately 75% of cells in a highly enriched long-term repopu... | [
{
"docid": "10526279",
"title": "Oxymetholone Therapy of Fanconi Anemia Suppresses Osteopontin Transcription and Induces Hematopoietic Stem Cell Cycling",
"text": "Androgens are widely used for treating Fanconi anemia (FA) and other human bone marrow failure syndromes, but their mode of action remains i... |
445 | GATA3 regulates self-renewal capacity in bone marrow hematopoietic stem cells. | [
{
"docid": "10165258",
"title": "GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry.",
"text": "Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells. Approximately 75% of cells in a highly enriched long-term repopu... | [
{
"docid": "10015292",
"title": "A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.",
"text": "Highly regenerative tissues such as blood must possess effective DNA damage responses (DDR) that balance long-term regeneration w... |
447 | Gastric infection with Helicobacter pylori decreases risk of gastric cancer in humans. | [
{
"docid": "2052720",
"title": "Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.",
"text": "OBJECTIVE To investigate the association between gastric cancer and prior infection with Helicobacter pylori. \n DESIGN Case-control ... | [
{
"docid": "24705390",
"title": "Chronic Helicobacter pylori infections induce gastric mutations in mice.",
"text": "BACKGROUND & AIMS Helicobacter pylori is an important etiologic factor in the development of gastric cancer. The aim of this study was to analyze the role of H. pylori infections in the i... |
448 | Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans. | [
{
"docid": "2052720",
"title": "Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.",
"text": "OBJECTIVE To investigate the association between gastric cancer and prior infection with Helicobacter pylori. \n DESIGN Case-control ... | [
{
"docid": "24705390",
"title": "Chronic Helicobacter pylori infections induce gastric mutations in mice.",
"text": "BACKGROUND & AIMS Helicobacter pylori is an important etiologic factor in the development of gastric cancer. The aim of this study was to analyze the role of H. pylori infections in the i... |
449 | Gastric lavage is an effective treatment for acute paraquat poisoning. | [
{
"docid": "12209494",
"title": "Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial",
"text": "BACKGROUND The case-fatality for intentional self-poisoning in the rural developing world is 10-50-fold higher than that in industrialised countries, mostly because of the ... | [
{
"docid": "33203108",
"title": "Golden Hours in Severe Paraquat Poisoning-The Role of Early Haemoperfusion Therapy.",
"text": "INTRODUCTION Paraquat is a commonly ingested poison especially in Southern India. There is no antidote for paraquat poison and consumption is often fatal. The usual cause of de... |
453 | General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder. | [
{
"docid": "4200695",
"title": "Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study",
"text": "OBJECTIVE To evaluate if a specific exercise strategy, targeting the rotator cuff and scapula stabilisers, improves shoulder ... | [
{
"docid": "38493521",
"title": "Corticosteroid injections for shoulder pain.",
"text": "BACKGROUND While many treatments, including corticosteroid injections in and around the shoulder, are advocated to be of benefit for shoulder pain, few are of proven efficacy. This review of corticosteroid injection... |
454 | General exercise therapy is more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder. | [
{
"docid": "4200695",
"title": "Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study",
"text": "OBJECTIVE To evaluate if a specific exercise strategy, targeting the rotator cuff and scapula stabilisers, improves shoulder ... | [
{
"docid": "53779698",
"title": "Exercise as a therapeutic approach to improve blood pressure in patients with peripheral arterial disease: current literature and future directions.",
"text": "INTRODUCTION Patients with symptomatic peripheral artery disease (PAD) exhibit reduced functional capacity and ... |
455 | Genes involved in pre-mRNA splicing have a significant impact on genome stability. | [
{
"docid": "12643937",
"title": "A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.",
"text": "Signaling pathways that respond to DNA damage are essential for the maintenance of genome stability and are linked to many diseases, including cancer. Her... | [
{
"docid": "4162857",
"title": "Linking Splicing to Pol II Transcription Stabilizes Pre-mRNAs and Influences Splicing Patterns",
"text": "RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in v... |
456 | Genes regulated by Esrrb transcription factor are sensitive to Mbd3 function. | [
{
"docid": "30507607",
"title": "An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells",
"text": "Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent cell identity. Whereas the genomic locations of several pluripotency transcription factors have ... | [
{
"docid": "6826100",
"title": "The developmental potential of iPSCs is greatly influenced by reprogramming factor selection.",
"text": "Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4, and Myc (OSKM) into cells. Although iPSCs are pluripotent, they freq... |
458 | Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity. | [
{
"docid": "597790",
"title": "Deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice",
"text": "Although mast cell functions have classically been related to allergic responses, recent studies indicate that these cells contribute to other common dise... | [
{
"docid": "52865789",
"title": "Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues",
"text": "OBJECTIVE IL-15 is an inflammatory cytokine secreted by many cell types. IL-15 is also produced during physical exe... |
461 | Genetic deletion of JAM-A increases gut permeability. | [
{
"docid": "40096222",
"title": "Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis.",
"text": "Mice lacking junctional adhesion molecule A (JAM-A, encoded by F11r) exhibit enhanced intestinal epithelial permeability, bacterial translocation, and el... | [
{
"docid": "15578265",
"title": "A model for the role of gut bacteria in the development of autoimmunity for type 1 diabetes",
"text": "Several lines of evidence suggest a role for the gut microbiome in type 1 diabetes. Treating diabetes-prone rodents with probiotics or antibiotics prevents the developm... |
463 | Genomic aberrations of metastases provide information for targeted therapy. | [
{
"docid": "19736671",
"title": "Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers",
"text": "Human tumors show a high level of genetic heterogeneity, but the processes that influence the timing and route of metastatic dissemination of the subclones are unknown... | [
{
"docid": "4325398",
"title": "Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes",
"text": "Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively acc... |
466 | Genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome (HGPS) are abundant in the ''progerinonly'' allele of Lmna knock-in models. | [
{
"docid": "22544171",
"title": "Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome",
"text": "Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in lamin A (encoded by LMNA), one o... | [
{
"docid": "15692098",
"title": "Hutchinson-Gilford progeria syndrome: review of the phenotype",
"text": "Hutchinson-Gilford progeria syndrome (HGPS) is a rare but well known entity characterized by extreme short stature, low body weight, early loss of hair, lipodystrophy, scleroderma, decreased joint m... |
469 | Glial calcium waves influence seizures. | [
{
"docid": "1410197",
"title": "An Excitatory Loop with Astrocytes Contributes to Drive Neurons to Seizure Threshold",
"text": "Seizures in focal epilepsies are sustained by a highly synchronous neuronal discharge that arises at restricted brain sites and subsequently spreads to large portions of the br... | [
{
"docid": "15889329",
"title": "A JOURNAL OF NEUROLOGY",
"text": "Brain glial cells, five times more prevalent than neurons, have recently received attention for their potential involvement in epileptic seizures. Microglia and astrocytes, associated with inflammatory innate immune responses, are respon... |
470 | Glioblastoma multiforme (GBM) is characterized by extensive invasion, rapid growth, necrosis, and angiogenesis. | [
{
"docid": "12685434",
"title": "Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma",
"text": "Although GBP1 (guanylate binding protein 1) was among the first interferon-inducible proteins identified, its function is still largely unknown. Epidermal growth factor rec... | [
{
"docid": "13235609",
"title": "VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex.",
"text": "Inhibition of VEGF signaling leads to a proinvasive phenotype in mouse models of glioblastoma multiforme (GBM) and in a subset of GBM patients treated with bevacizumab. ... |
472 | Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae. | [
{
"docid": "7185591",
"title": "Sir2-Independent Life Span Extension by Calorie Restriction in Yeast",
"text": "Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Her... | [
{
"docid": "1754001",
"title": "Yeast sirtuins and the regulation of aging.",
"text": "The sirtuins are a phylogenetically conserved family of NAD(+) -dependent protein deacetylases that consume one molecule of NAD(+) for every deacetylated lysine side chain. Their requirement for NAD(+) potentially mak... |
473 | Glycan adaptation involves insertion-deletion events. | [
{
"docid": "4373433",
"title": "Broad neutralization coverage of HIV by multiple highly potent antibodies",
"text": "Broadly neutralizing antibodies against highly variable viral pathogens are much sought after to treat or protect against global circulating viruses. Here we probed the neutralizing antib... | [
{
"docid": "25942757",
"title": "PSGL-1 function in immunity and steady state homeostasis.",
"text": "The substantial importance of P-selectin glycoprotein ligand 1 (PSGL-1) in leukocyte trafficking has continued to emerge beyond its initial identification as a selectin ligand. PSGL-1 seemed to be a rel... |
474 | Glycan adaptation is rarely observed in the B-cell repertoire. | [
{
"docid": "4373433",
"title": "Broad neutralization coverage of HIV by multiple highly potent antibodies",
"text": "Broadly neutralizing antibodies against highly variable viral pathogens are much sought after to treat or protect against global circulating viruses. Here we probed the neutralizing antib... | [
{
"docid": "1471041",
"title": "High abundance of plasma cells secreting transglutaminase 2–specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions",
"text": "Celiac disease is an immune-mediated disorder in which mucosal autoantibodies to the enzyme transglut... |
479 | Gpr124 increases BBB breakdown in mouse models of ischemic stroke. | [
{
"docid": "6325527",
"title": "Gpr124 is essential for blood–brain barrier integrity in central nervous system disease",
"text": "Although blood–brain barrier (BBB) compromise is central to the etiology of diverse central nervous system (CNS) disorders, endothelial receptor proteins that control BBB fu... | [
{
"docid": "3761017",
"title": "Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion",
"text": "BACKGROUND Metformin, a widely used hypoglycemic drug, reduces stroke incidence and alleviates chronic inflammation in clinical trials. However, the effect of... |
480 | Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke. | [
{
"docid": "6325527",
"title": "Gpr124 is essential for blood–brain barrier integrity in central nervous system disease",
"text": "Although blood–brain barrier (BBB) compromise is central to the etiology of diverse central nervous system (CNS) disorders, endothelial receptor proteins that control BBB fu... | [
{
"docid": "3761017",
"title": "Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion",
"text": "BACKGROUND Metformin, a widely used hypoglycemic drug, reduces stroke incidence and alleviates chronic inflammation in clinical trials. However, the effect of... |
481 | Guanine nucleotide dissociation inhibitor (Rho-GDI) interacts with the p75 NTR death domain | [
{
"docid": "14706752",
"title": "Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor",
"text": "The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly... | [
{
"docid": "368506",
"title": "Generation of mice with a conditional allele for the p75(NTR) neurotrophin receptor gene.",
"text": "The p75(NTR) neurotrophin receptor has been implicated in multiple biological and pathological processes. While significant advances have recently been made in understandin... |
482 | Guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins. | [
{
"docid": "10991183",
"title": "The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins",
"text": "How individual cells respond to mechanical forces is of considerable interest to biologists as force affects many aspects of cell behaviour. The application of force on integri... | [
{
"docid": "33076846",
"title": "Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.",
"text": "Polyploidization can precede the development of aneuploidy in cancer. Polyploidization in megakaryocytes (Mks), in contrast, is a highly controlled developmental pro... |
483 | H.pylori-mediated gastric cancer occurs due to the accumulation of mutations in host epithelial cells. | [
{
"docid": "22703082",
"title": "Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium",
"text": "Infection with Helicobacter pylori (H. pylori) is a risk factor for the development of gastric cancer. Here we show that infection of gast... | [
{
"docid": "24705390",
"title": "Chronic Helicobacter pylori infections induce gastric mutations in mice.",
"text": "BACKGROUND & AIMS Helicobacter pylori is an important etiologic factor in the development of gastric cancer. The aim of this study was to analyze the role of H. pylori infections in the i... |
484 | H4 G94P proteins induce chromatin assembly, which increases free histones. | [
{
"docid": "14637235",
"title": "Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis",
"text": "Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these hi... | [
{
"docid": "7137057",
"title": "Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones.",
"text": "BACKGROUND & AIMS HBV covalently closed circular DNA (cccDNA), the replicative intermediate responsible for persistent HBV infection of he... |
485 | H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms. | [
{
"docid": "14637235",
"title": "Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis",
"text": "Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these hi... | [
{
"docid": "13907427",
"title": "DNA repair factor APLF is a histone chaperone.",
"text": "Poly(ADP-ribosyl)ation plays a major role in DNA repair, where it regulates chromatin relaxation as one of the critical events in the repair process. However, the molecular mechanism by which poly(ADP-ribose) modu... |
486 | H4 G94P proteins inhibit chromatin assembly, which decreases free histones. | [
{
"docid": "14637235",
"title": "Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis",
"text": "Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these hi... | [
{
"docid": "7137057",
"title": "Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones.",
"text": "BACKGROUND & AIMS HBV covalently closed circular DNA (cccDNA), the replicative intermediate responsible for persistent HBV infection of he... |
487 | H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms. | [
{
"docid": "14637235",
"title": "Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis",
"text": "Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these hi... | [
{
"docid": "25606339",
"title": "Toll-like receptor-3 mediates HIV-1 transactivation via NFκB and JNK pathways and histone acetylation, but prolonged activation suppresses Tat and HIV-1 replication.",
"text": "TLR3 has been implicated in the pathogenesis of several viral infections, including SIV- and H... |
488 | HAND2 methylation is a key step in early endometrial carcinogenesis. | [
{
"docid": "1780819",
"title": "Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development",
"text": "BACKGROUND Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer developmen... | [
{
"docid": "11359243",
"title": "Large-scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization.",
"text": "Altered DNA methylation occurs ubiquitously in human cancer from the earliest measurable stages. A cogent approach to understanding the mechanism and timing of... |
489 | HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons. | [
{
"docid": "6625693",
"title": "Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex",
"text": "The use of N-type voltage-gated calcium channel (CaV2.2) blockers to treat pain is limited by many physiological side effects. Here we report that in... | [
{
"docid": "5473074",
"title": "Solution NMR structure of the TatA component of the twin-arginine protein transport system from gram-positive bacterium Bacillus subtilis.",
"text": "The twin-arginine transport (Tat) system translocates folded proteins across the bacterial cytoplasmic or chloroplast thyl... |
490 | HNF4A mutations are associated with macrosomia in infancy. | [
{
"docid": "56893404",
"title": "Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene",
"text": "Background Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increase... | [
{
"docid": "24269361",
"title": "Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review.",
"text": "There are two main families of polyunsaturated fatty acids (PUFAs), the n-6 and the n-3 families. It has been suggested... |
492 | HOXB4 facilitates HSC expansion when co-cultured with HSCs. | [
{
"docid": "19583924",
"title": "Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells",
"text": "Successful ex vivo expansion of hematopoietic stem cells (HSCs) would greatly benefit the treatment of disease and the understanding of crucial questions of stem cell biology. H... | [
{
"docid": "92499",
"title": "The journey of developing hematopoietic stem cells.",
"text": "Hematopoietic stem cells (HSCs) develop during embryogenesis in a complex process that involves multiple anatomical sites. Once HSC precursors have been specified from mesoderm, they have to mature into function... |
493 | HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations. | [
{
"docid": "19583924",
"title": "Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells",
"text": "Successful ex vivo expansion of hematopoietic stem cells (HSCs) would greatly benefit the treatment of disease and the understanding of crucial questions of stem cell biology. H... | [
{
"docid": "515489",
"title": "Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell-like property of hepatocellular carcinoma cells by stabilizing NOP2.",
"text": "UNLABELLED Many protein-coding oncofetal genes are highly expressed in murine and human fetal liver and silenced in adult ... |
494 | HSCT-T dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before AMI. | [
{
"docid": "34873974",
"title": "Diagnostic accuracy of single baseline measurement of Elecsys Troponin T high-sensitive assay for diagnosis of acute myocardial infarction in emergency department: systematic review and meta-analysis",
"text": "OBJECTIVE To obtain summary estimates of the accuracy of a s... | [
{
"docid": "13223957",
"title": "Pain attacks in non-complicated and complicated gallstone disease have a characteristic pattern and are accompanied by dyspepsia in most patients: the results of a prospective study.",
"text": "OBJECTIVE The cardinal indication for surgical treatment of gallstones is pai... |
495 | Having a main partner improves HIV outcomes. | [
{
"docid": "17077004",
"title": "Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study.",
"text": "OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patient... | [
{
"docid": "5835149",
"title": "Hepatitis C virus infection in a large cohort of homosexually active men: independent associations with HIV-1 infection and injecting drug use but not sexual behaviour.",
"text": "OBJECTIVE To determine the prevalence and risk factors for hepatitis C virus (HCV) infection... |
498 | Having a main partner worsens HIV outcomes. | [
{
"docid": "17077004",
"title": "Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study.",
"text": "OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patient... | [
{
"docid": "5835149",
"title": "Hepatitis C virus infection in a large cohort of homosexually active men: independent associations with HIV-1 infection and injecting drug use but not sexual behaviour.",
"text": "OBJECTIVE To determine the prevalence and risk factors for hepatitis C virus (HCV) infection... |
499 | HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT). | [
{
"docid": "26064662",
"title": "Association of Sickle Cell Trait With Hemoglobin A1c in African Americans",
"text": "Importance Hemoglobin A1c (HbA1c) reflects past glucose concentrations, but this relationship may differ between those with sickle cell trait (SCT) and those without it. Objective To eva... | [
{
"docid": "12662435",
"title": "Reversing the tide — diagnosis and prevention of T2DM in populations of African descent",
"text": "Abstract | Populations of African descent are at the forefront of the worldwide epidemic of type 2 diabetes mellitus (T2DM). The burden of T2DM is amplified by diagnosis af... |
500 | Headaches are correlated with cognitive impairment. | [
{
"docid": "17930286",
"title": "Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing-MRI study",
"text": "OBJECTIVE To evaluate the association of overall and specific headaches with volume of white matter hyperintensities, brain infarcts, and ... | [
{
"docid": "24865781",
"title": "A comparison of pharmacological (amitriptyline HCL) and nonpharmacological (cognitive-behavioral) therapies for chronic tension headaches.",
"text": "Forty-one recurrent tension headache sufferers were randomly assigned to either cognitive-behavioral therapy (administere... |
504 | Healthy volunteers exhibit rapid and transient increase of cellular ATP after being bolus-injected with fructose. | [
{
"docid": "10883736",
"title": "Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study.",
"text": "CONTEXT The mechanisms that drive progression from fatty liver to steatohepatitis and cirrhosis are unknown. In animal models, obese mice with fatty livers are vulnerabl... | [
{
"docid": "38401028",
"title": "The cause of hepatic accumulation of fructose 1-phosphate on fructose loading.",
"text": "1. The changes in the metabolite content in freeze-clamped livers of fed rats occurring on perfusion with 10mm-d-fructose have been examined. 2. The most striking effects of fructos... |
505 | Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA. | [
{
"docid": "22703082",
"title": "Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium",
"text": "Infection with Helicobacter pylori (H. pylori) is a risk factor for the development of gastric cancer. Here we show that infection of gast... | [
{
"docid": "2638387",
"title": "The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA",
"text": "High mutation frequency during reverse transcription has a principal role in the genetic variation of primate lentiviral populations. It is the main driving force for the generati... |
506 | Helminths interfere with immune system control of coinfections by microbial pathogens 16. | [
{
"docid": "7433668",
"title": "Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway",
"text": "Tuberculosis and helminthic infections coexist in many parts of the world, yet the impact of helminth-elicited Th2 responses on... | [
{
"docid": "45401535",
"title": "Candida albicans-Staphylococcus aureus polymicrobial peritonitis modulates host innate immunity.",
"text": "Despite advances in medical device fabrication and antimicrobial treatment therapies, fungal-bacterial polymicrobial peritonitis remains a serious complication for... |
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