query_id stringlengths 1 4 | query stringlengths 26 249 | positive_passages listlengths 1 5 | negative_passages listlengths 16 20 |
|---|---|---|---|
682 | Lack of FGF21 in mice leads to reduced lifespan. | [
{
"docid": "9315213",
"title": "Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice",
"text": "BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glu... | [
{
"docid": "23397658",
"title": "Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives.",
"text": "Fibroblast growth factor 21 (FGF21), a metabolic hormone predominantly produced by the liver, is also expressed in adipocytes and the pancreas. It regulates glucose and lipi... |
683 | Lack of FGF21 in mice slows the rate of atherosclerotic plaque formation. | [
{
"docid": "9315213",
"title": "Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice",
"text": "BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glu... | [
{
"docid": "4890578",
"title": "Atherosclerotic plaque rupture--pathologic basis of plaque stability and instability.",
"text": "Time for primary reveiw 27 days Atherosclerosis continues to be one of the main subjects in pathology research. The intriguing complexity of its pathogenesis as well as the ... |
685 | Lamins are associated with nuclear membrane structure maintenance. | [
{
"docid": "4452659",
"title": "Autophagy mediates degradation of nuclear lamina",
"text": "Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies h... | [
{
"docid": "25036988",
"title": "Loss of lamin B1 results in prolongation of S phase and decondensation of chromosome territories.",
"text": "Nuclear lamin B1 (LMNB1) constitutes one of the major structural proteins in the lamina mesh. We silenced the expression of LMNB1 by RNA interference in the colon... |
686 | Lamins are found within the inner layer of the mitochondrial membrane of all cells. | [
{
"docid": "4452659",
"title": "Autophagy mediates degradation of nuclear lamina",
"text": "Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies h... | [
{
"docid": "797114",
"title": "A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology☆",
"text": "A recent study revealed a mechanism of delaying aging in yeast by a natural compound which specifically ... |
687 | Lamins are found within the inner layer of the nuclear membrane of all cells. | [
{
"docid": "4452659",
"title": "Autophagy mediates degradation of nuclear lamina",
"text": "Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies h... | [
{
"docid": "34747208",
"title": "Lamin A-dependent nuclear defects in human aging.",
"text": "Mutations in the nuclear structural protein lamin A cause the premature aging syndrome Hutchinson-Gilford progeria (HGPS). Whether lamin A plays any role in normal aging is unknown. We show that the same molecu... |
688 | Lamins have no effect on nuclear membrane structure maintenance. | [
{
"docid": "4452659",
"title": "Autophagy mediates degradation of nuclear lamina",
"text": "Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies h... | [
{
"docid": "25036988",
"title": "Loss of lamin B1 results in prolongation of S phase and decondensation of chromosome territories.",
"text": "Nuclear lamin B1 (LMNB1) constitutes one of the major structural proteins in the lamina mesh. We silenced the expression of LMNB1 by RNA interference in the colon... |
689 | Less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells. | [
{
"docid": "22080671",
"title": "KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis",
"text": "Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controv... | [
{
"docid": "25238950",
"title": "FGF-2 enhances intestinal stem cell survival and its expression is induced after radiation injury.",
"text": "Fibroblast growth factors (FGFs) have mitogenic activity toward a wide variety of cells of mesenchymal, neuronal, and epithelial origin and regulate events in no... |
694 | Lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells. | [
{
"docid": "1071991",
"title": "Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines",
"text": "Live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) remain the most efficacious of all vaccines in nonhuman primate models of HIV and AIDS, yet the basis of their r... | [
{
"docid": "8182950",
"title": "Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose.",
"text": "In subunit vaccines, strong CD8(+) T-cell responses are desired, yet they are elusive at reasonable adjuvant doses. We show that targeting adjuvant to the ly... |
696 | Lipopolysaccharides have an inflammation independent effect on kidney barrier function. | [
{
"docid": "16355392",
"title": "Modification of kidney barrier function by the urokinase receptor",
"text": "Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are... | [
{
"docid": "27545868",
"title": "Histone acetyltransferase PCAF regulates inflammatory molecules in the development of renal injury.",
"text": "Kidney diseases, including chronic kidney disease (CKD) and acute kidney injury (AKI), are associated with inflammation. The mechanism that regulates inflammati... |
698 | Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS). | [
{
"docid": "22544171",
"title": "Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome",
"text": "Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in lamin A (encoded by LMNA), one o... | [
{
"docid": "15692098",
"title": "Hutchinson-Gilford progeria syndrome: review of the phenotype",
"text": "Hutchinson-Gilford progeria syndrome (HGPS) is a rare but well known entity characterized by extreme short stature, low body weight, early loss of hair, lipodystrophy, scleroderma, decreased joint m... |
703 | Localization of PIN1 in the roots of Arabidopsis requires VPS9a | [
{
"docid": "4350400",
"title": "Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions",
"text": "Dynamically polarized membrane proteins define different cell boundaries and have an important role in intercellular communication—a vital feature of multicellul... | [
{
"docid": "16557565",
"title": "Local, Efflux-Dependent Auxin Gradients as a Common Module for Plant Organ Formation",
"text": "Plants, compared to animals, exhibit an amazing adaptability and plasticity in their development. This is largely dependent on the ability of plants to form new organs, such a... |
704 | Long - range chromatin interactions regulate transcription. | [
{
"docid": "14658685",
"title": "Enhancer Evolution across 20 Mammalian Species",
"text": "The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promote... | [
{
"docid": "18276599",
"title": "Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation",
"text": "Higher-order chromosomal organization for transcription regulation is poorly understood in eukaryotes. Using genome-wide Chromatin Interaction Analysis ... |
705 | Long chain polyunsaturated fatty acids supplementation has no significant effects on wheezing or asthma at 3 and 6 years. | [
{
"docid": "22442133",
"title": "Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants’ allergies in first year of life: randomised controlled trial",
"text": "OBJECTIVE To determine whether dietary n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation ... | [
{
"docid": "24269361",
"title": "Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review.",
"text": "There are two main families of polyunsaturated fatty acids (PUFAs), the n-6 and the n-3 families. It has been suggested... |
709 | Long chain polyunsaturated fatty acids supplementation is associated with lower rates of atopic eczema at 1 year. | [
{
"docid": "22442133",
"title": "Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants’ allergies in first year of life: randomised controlled trial",
"text": "OBJECTIVE To determine whether dietary n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation ... | [
{
"docid": "24269361",
"title": "Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review.",
"text": "There are two main families of polyunsaturated fatty acids (PUFAs), the n-6 and the n-3 families. It has been suggested... |
710 | Long chain polyunsaturated fatty acids supplementation reduces wheezing and asthma. | [
{
"docid": "22442133",
"title": "Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants’ allergies in first year of life: randomised controlled trial",
"text": "OBJECTIVE To determine whether dietary n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation ... | [
{
"docid": "24269361",
"title": "Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review.",
"text": "There are two main families of polyunsaturated fatty acids (PUFAs), the n-6 and the n-3 families. It has been suggested... |
713 | Low expression of miR7a does not repress target genes or exert a biological function in ovaries. | [
{
"docid": "18421962",
"title": "Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance.",
"text": "Recent studies have reported that competitive endogenous RNAs (ceRNAs) can act as sponges for a microRNA (miRNA) through their binding sites and that changes in ceRNA ... | [
{
"docid": "15635366",
"title": "The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.",
"text": "L3mbtl2 has been implicated in transcriptional repression and chromatin compaction but its biological function has n... |
714 | Low expression of miR7a does not repress target genes or exert a biological function in testis. | [
{
"docid": "18421962",
"title": "Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance.",
"text": "Recent studies have reported that competitive endogenous RNAs (ceRNAs) can act as sponges for a microRNA (miRNA) through their binding sites and that changes in ceRNA ... | [
{
"docid": "15635366",
"title": "The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.",
"text": "L3mbtl2 has been implicated in transcriptional repression and chromatin compaction but its biological function has n... |
717 | Low nucleosome occupancy correlates with high methylation levels across species. | [
{
"docid": "17587795",
"title": "Dnmt1-Independent CG Methylation Contributes to Nucleosome Positioning in Diverse Eukaryotes",
"text": "Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their genomes are typically depleted of CG dinucleotides because of imperfect repair of ... | [
{
"docid": "175735",
"title": "Inferring nucleosome positions with their histone mark annotation from ChIP data",
"text": "MOTIVATION The nucleosome is the basic repeating unit of chromatin. It contains two copies each of the four core histones H2A, H2B, H3 and H4 and about 147 bp of DNA. The residues o... |
724 | Ly49Q directs the organization of neutrophil polarization by regulating membrane raft functions. | [
{
"docid": "5531479",
"title": "The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.",
"text": "Neutrophils rapidly undergo polarization and directional movement to infiltrate the sites of infection and inflammation. Here, we show that an inhib... | [
{
"docid": "4389252",
"title": "Centrosome polarization delivers secretory granules to the immunological synapse",
"text": "Cytotoxic T lymphocytes (CTLs) destroy virally infected and tumorigenic cells by releasing the contents of specialized secretory lysosomes—termed ‘lytic granules’—at the immunologi... |
726 | Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes. | [
{
"docid": "7521113",
"title": "Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.",
"text": "Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense. Emer... | [
{
"docid": "22406695",
"title": "Origin and functions of tissue macrophages.",
"text": "Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and... |
730 | Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A. | [
{
"docid": "13400643",
"title": "A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth",
"text": "The pharmacological inhibition of general transcriptional regulators has the potential to block growth through targeting multiple tumorigenic signalling path... | [
{
"docid": "4387494",
"title": "Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia",
"text": "PURPOSE Acute myeloid leukemia (AML) is a heterogeneous disease with poor outcomes. Despite increased evidence shows that dysregulation of histone modificat... |
732 | M. stadtmanae does not induce ASC speck formation in BlaER1 monocytes. | [
{
"docid": "34469966",
"title": "Human Monocytes Engage an Alternative Inflammasome Pathway.",
"text": "Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of class... | [
{
"docid": "4345315",
"title": "Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3",
"text": "Missense mutations in the CIAS1 gene cause three autoinflammatory disorders: familial cold autoinflammatory syndrome, Muckle–Wells syndrome and neonatal-onset multiple-system... |
733 | M. stadtmanae induces ASC speck formation in BlaER1 monocytes. | [
{
"docid": "34469966",
"title": "Human Monocytes Engage an Alternative Inflammasome Pathway.",
"text": "Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of class... | [
{
"docid": "4345315",
"title": "Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3",
"text": "Missense mutations in the CIAS1 gene cause three autoinflammatory disorders: familial cold autoinflammatory syndrome, Muckle–Wells syndrome and neonatal-onset multiple-system... |
734 | MEK inhibitors are effective treatments in RAS-driven mouse models of cancer. | [
{
"docid": "4961038",
"title": "Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers",
"text": "Somatic mutations that activate phosphoinositide 3-kinase (PI3K) have been identified in the p110-alpha catalytic subunit (encoded by PIK3CA). They are mos... | [
{
"docid": "2272614",
"title": "Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer.",
"text": "Activating mutations in the EGF receptor (EGFR) are associated with clinical responsiveness to EGFR tyrosine kinase inhibitors (TKI), such as erlotinib and gefitinib. However, resistan... |
736 | MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins. | [
{
"docid": "5389095",
"title": "Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids",
"text": "Fatty acids are integral mediators of energy storage, membrane formation and cell signaling. The pathways that orchestrate uptake of fatty acids remain incompletely understood.... | [
{
"docid": "24335068",
"title": "Divalent cations differentially regulate integrin alphaIIb cytoplasmic tail binding to beta3 and to calcium- and integrin-binding protein.",
"text": "We have used recombinant or synthetic alphaIIb and beta3 integrin cytoplasmic peptides to study their in vitro complexati... |
737 | MICAL redox enzymes regulate actin dynamics in many cell types. | [
{
"docid": "16562534",
"title": "Drosophila MICAL regulates myofilament organization and synaptic structure",
"text": "The overall size and structure of a synaptic terminal is an important determinant of its function. In a large-scale mutagenesis screen, designed to identify Drosophila mutants with abno... | [
{
"docid": "4417558",
"title": "Mical links semaphorins to F-actin disassembly",
"text": "How instructive cues present on the cell surface have their precise effects on the actin cytoskeleton is poorly understood. Semaphorins are one of the largest families of these instructive cues and are widely studi... |
738 | MICAL redox enzymes regulate actin dynamics. | [
{
"docid": "16562534",
"title": "Drosophila MICAL regulates myofilament organization and synaptic structure",
"text": "The overall size and structure of a synaptic terminal is an important determinant of its function. In a large-scale mutagenesis screen, designed to identify Drosophila mutants with abno... | [
{
"docid": "4417558",
"title": "Mical links semaphorins to F-actin disassembly",
"text": "How instructive cues present on the cell surface have their precise effects on the actin cytoskeleton is poorly understood. Semaphorins are one of the largest families of these instructive cues and are widely studi... |
739 | MT binding domain drives amyloid structure formation. | [
{
"docid": "4446814",
"title": "Cryo-EM structures of Tau filaments from Alzheimer’s disease brain",
"text": "Alzheimer's disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuri... | [
{
"docid": "1684489",
"title": "CHD4 Is a RanGTP-Dependent MAP that Stabilizes Microtubules and Regulates Bipolar Spindle Formation",
"text": "BACKGROUND Production of the GTP-bound form of the Ran GTPase (RanGTP) around chromosomes induces spindle assembly by activating nuclear localization signal (NLS... |
740 | MUC1-C activates the NF-κB p65 signaling pathway by interacting with IκB kinase ß. | [
{
"docid": "23078022",
"title": "MUC1 oncoprotein activates the IκB kinase β complex and constitutive NF-κB signalling",
"text": "Nuclear factor-κB (NF-κB) is constitutively activated in diverse human malignancies by mechanisms that are not understood. The MUC1 oncoprotein is aberrantly overexpressed by... | [
{
"docid": "83308790",
"title": "Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway",
"text": "In mammals, the canonical nuclear factor κB (NF-κB) signaling pathway activated in response to infections is based on degradation of IκB inhibitors. This pathway depends on the IκB... |
745 | MafA phosphorylation decreases its ubiquitination. | [
{
"docid": "11291348",
"title": "GSK-3-mediated phosphorylation enhances Maf-transforming activity.",
"text": "The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 5... | [
{
"docid": "9680193",
"title": "Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation.",
"text": "The ubiquitin-binding protein Hrs and endosomal sorting complex required for transport (ESCRT)-I and ESCRT-III are involved in sortin... |
746 | MafA phosphorylation enhances its ubiquitination. | [
{
"docid": "11291348",
"title": "GSK-3-mediated phosphorylation enhances Maf-transforming activity.",
"text": "The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 5... | [
{
"docid": "21307488",
"title": "HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation",
"text": "HER-2/neu amplification or overexpression can make cancer cells resistant to apoptosis and promotes their growth. p53 is crucial in regulating cell growth and apoptosis, and is often mu... |
747 | MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA. | [
{
"docid": "11291348",
"title": "GSK-3-mediated phosphorylation enhances Maf-transforming activity.",
"text": "The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 5... | [
{
"docid": "3727986",
"title": "A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion",
"text": "Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables... |
748 | MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA. | [
{
"docid": "11291348",
"title": "GSK-3-mediated phosphorylation enhances Maf-transforming activity.",
"text": "The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 5... | [
{
"docid": "3727986",
"title": "A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion",
"text": "Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables... |
749 | Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation. | [
{
"docid": "13868795",
"title": "CD28 Costimulation: From Mechanism to Therapy.",
"text": "Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell receptor (TCR) ligation for naive T cell activation. Here, we discuss the expression, structure, and biochemistry of CD28... | [
{
"docid": "40608679",
"title": "Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion.",
"text": "Sustained signaling from the T cell receptor (TCR) and costimulatory molecules is thought necessary for generating high numbers of effector T cells. Here, we show tha... |
751 | Major vault protein (MVP) leads to more aggressive tumors by regulating the sorting of tumor suppressive miR-193a into extracellular vesicles (EVs). | [
{
"docid": "19800147",
"title": "MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression",
"text": "Exosomes are emerging mediators of intercellular communication; whether the release of exosomes has an effect on the exosome donor cells in addition to the recipient cells has not been... | [
{
"docid": "1905095",
"title": "Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction.",
"text": "AIMS Recent evidence suggests that cardiac progenitor cells (CPCs) may improve cardiac function after injury. Th... |
752 | Major vault protein regulates sorting of tumor suppressive miR-193a into EVs. | [
{
"docid": "19800147",
"title": "MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression",
"text": "Exosomes are emerging mediators of intercellular communication; whether the release of exosomes has an effect on the exosome donor cells in addition to the recipient cells has not been... | [
{
"docid": "1905095",
"title": "Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction.",
"text": "AIMS Recent evidence suggests that cardiac progenitor cells (CPCs) may improve cardiac function after injury. Th... |
753 | Malaria has a high vectorial capacity. | [
{
"docid": "1173667",
"title": "Ranking of elimination feasibility between malaria-endemic countries",
"text": "Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malar... | [
{
"docid": "25938221",
"title": "The spectrum of retinopathy in adults with Plasmodium falciparum malaria",
"text": "A specific retinopathy has been described in African children with cerebral malaria, but in adults this has not been extensively studied. Since the structure and function of the retinal v... |
755 | Many cytokines that are produced by cancer cells also contribute to carcinogenesis. | [
{
"docid": "17844478",
"title": "Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development",
"text": "It is established that tumor cell-derived VEGF acts on endothelial cells to promote angiogenesis and tumor growth. Here, we demonstrate that in K5-SOS-depende... | [
{
"docid": "31933981",
"title": "Serum amyloid A: An acute-phase protein involved in tumour pathogenesis",
"text": "The synthesis of acute-phase protein serum amyloid A (SAA) is largely regulated by inflammation- associated cytokines and a high concentration of circulating SAA may represent an ideal mar... |
757 | Many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane. | [
{
"docid": "17123657",
"title": "Dynamic Helix Interactions in Transmembrane Signaling",
"text": "Studying how protein transmembrane domains transmit signals across membranes is beset by unique challenges. Here, we discuss the circumstances that have led to success and reflect on what has been learned f... | [
{
"docid": "2617858",
"title": "Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin",
"text": "Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Solu... |
758 | Marmosets have a brain region homologous to Broca's area. | [
{
"docid": "14195528",
"title": "Responses of primate frontal cortex neurons during natural vocal communication.",
"text": "The role of primate frontal cortex in vocal communication and its significance in language evolution have a controversial history. While evidence indicates that vocalization proces... | [
{
"docid": "1391126",
"title": "Activation of Frontal Neocortical Areas by Vocal Production in Marmosets",
"text": "Primates often rely on vocal communication to mediate social interactions. Although much is known about the acoustic structure of primate vocalizations and the social context in which they... |
760 | Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have only a modest impact in reducing malaria transmission. | [
{
"docid": "1805641",
"title": "Modelling the Impact of Artemisinin Combination Therapy and Long-Acting Treatments on Malaria Transmission Intensity",
"text": "BACKGROUND Artemisinin derivatives used in recently introduced combination therapies (ACTs) for Plasmodium falciparum malaria significantly lowe... | [
{
"docid": "3929361",
"title": "Optimising Strategies for Plasmodium falciparum Malaria Elimination in Cambodia: Primaquine, Mass Drug Administration and Artemisinin Resistance",
"text": "BACKGROUND Malaria elimination requires a variety of approaches individually optimized for different transmission se... |
761 | MeCP2 influences the synaptic maturation of neurons. | [
{
"docid": "10009203",
"title": "Structural Homeostasis: Compensatory Adjustments of Dendritic Arbor Geometry in Response to Variations of Synaptic Input ",
"text": "As the nervous system develops, there is an inherent variability in the connections formed between differentiating neurons. Despite this v... | [
{
"docid": "41644178",
"title": "Increased dendritic complexity and axonal length in cultured mouse cortical neurons overexpressing methyl-CpG-binding protein MeCP2",
"text": "Rett syndrome is caused by loss-of-function mutations in the gene encoding the methyl DNA-binding factor MeCP2. As brain mass an... |
762 | Measuring routine outcomes is more beneficial to clinical practice than assessing treatment adherence. | [
{
"docid": "4695046",
"title": "Anxiety",
"text": "OBJECTIVES To examine the effect of routinely administered psychiatric questionnaires on the recognition, management, and outcome of psychiatric disorders in non-psychiatric settings. \n DATA SOURCES Embase, Medline, PsycLIT, Cinahl, Cochrane Controll... | [
{
"docid": "5824985",
"title": "Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.",
"text": "BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contempor... |
764 | Medications to treat obesity are highly effective. | [
{
"docid": "7552215",
"title": "Long term pharmacotherapy for obesity and overweight: updated meta-analysis.",
"text": "OBJECTIVE To summarise the long term efficacy of anti-obesity drugs in reducing weight and improving health status. \n DESIGN Updated meta-analysis of randomised trials. \n DATA SO... | [
{
"docid": "11481946",
"title": "Obesity, type 2 diabetes, and cancer: the insulin and IGF connection.",
"text": "Epidemiological studies suggest a positive association between obesity and type 2 diabetes mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance, hyperinsul... |
765 | Medications to treat obesity do not have side effects. | [
{
"docid": "7552215",
"title": "Long term pharmacotherapy for obesity and overweight: updated meta-analysis.",
"text": "OBJECTIVE To summarise the long term efficacy of anti-obesity drugs in reducing weight and improving health status. \n DESIGN Updated meta-analysis of randomised trials. \n DATA SO... | [
{
"docid": "23397658",
"title": "Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives.",
"text": "Fibroblast growth factor 21 (FGF21), a metabolic hormone predominantly produced by the liver, is also expressed in adipocytes and the pancreas. It regulates glucose and lipi... |
766 | Medications to treat obesity have unwanted side effects. | [
{
"docid": "7552215",
"title": "Long term pharmacotherapy for obesity and overweight: updated meta-analysis.",
"text": "OBJECTIVE To summarise the long term efficacy of anti-obesity drugs in reducing weight and improving health status. \n DESIGN Updated meta-analysis of randomised trials. \n DATA SO... | [
{
"docid": "23397658",
"title": "Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives.",
"text": "Fibroblast growth factor 21 (FGF21), a metabolic hormone predominantly produced by the liver, is also expressed in adipocytes and the pancreas. It regulates glucose and lipi... |
767 | Men are more susceptible to death due to pneumonia when compared to women. | [
{
"docid": "2488880",
"title": "Gender-dependent differences in outcome after the treatment of infection in hospitalized patients.",
"text": "CONTEXT While it is established that management strategies and outcomes differ by gender for many diseases, its effect on infection has not been adequately studie... | [
{
"docid": "33835579",
"title": "Pathology of postprimary tuberculosis in humans and mice: contradiction of long-held beliefs.",
"text": "Tuberculosis remains one of the world's leading infectious causes of death. Approximately 80% of all disease is due to postprimary (secondary) tuberculosis in the lun... |
771 | Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients. | [
{
"docid": "15476777",
"title": "Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial",
"text": "BACKGROUND Elderly and frail patients with cancer, although often treated with chemotherapy, are under-represented in c... | [
{
"docid": "2492146",
"title": "Comparative Safety of Targeted Therapies for Metastatic Colorectal Cancer between Elderly and Younger Patients: a Study Using the International Pharmacovigilance Database",
"text": "Metastatic colorectal cancer (mCRC) is increasingly treated using targeted therapies. Post... |
772 | Mice are incapable of producing neutralizing antibodies in reponse to the Chikungunya virus (CHIKV) produced in mosquitos. | [
{
"docid": "24922825",
"title": "A chikungunya fever vaccine utilizing an insect-specific virus platform",
"text": "Traditionally, vaccine development involves tradeoffs between immunogenicity and safety. Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety when co... | [
{
"docid": "152245",
"title": "Effects of an opal termination codon preceding the nsP4 gene sequence in the O'Nyong-Nyong virus genome on Anopheles gambiae infectivity.",
"text": "The genomic RNA of an alphavirus encodes four different nonstructural proteins, nsP1, nsP2, nsP3, and nsP4. The polyprotein ... |
774 | Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) fail to reveal increased sensitivity to ionizing radiation (IR). | [
{
"docid": "32275758",
"title": "Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo.",
"text": "DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of ... | [
{
"docid": "11569583",
"title": "Deregulated DNA polymerase β strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities",
"text": "DNA polymerase β (Pol β) is an error-prone enzyme which has been found to be overexpressed in several human tumors. By using a couple of recombinant C... |
776 | Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR). | [
{
"docid": "32275758",
"title": "Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo.",
"text": "DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of ... | [
{
"docid": "11569583",
"title": "Deregulated DNA polymerase β strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities",
"text": "DNA polymerase β (Pol β) is an error-prone enzyme which has been found to be overexpressed in several human tumors. By using a couple of recombinant C... |
777 | Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR). | [
{
"docid": "32275758",
"title": "Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo.",
"text": "DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of ... | [
{
"docid": "11569583",
"title": "Deregulated DNA polymerase β strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities",
"text": "DNA polymerase β (Pol β) is an error-prone enzyme which has been found to be overexpressed in several human tumors. By using a couple of recombinant C... |
778 | Mice lacking Sirt1 in Sf1-expressing neurons are immune to diet-induced obesity and insulin resistance. | [
{
"docid": "13001323",
"title": "SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.",
"text": "Chronic feeding on high-calorie diets causes obesity and type 2 diabetes mellitus (T2DM), illnesses that affect hundreds of millions. Thus, understanding the pathways protecting against die... | [
{
"docid": "2481032",
"title": "Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues.",
"text": "Sirt1 is a NAD(+)-dependent class III deacetylase that functions as a cellular energy sensor. In addition to its well-characterized effects in peripheral tissues, emer... |
779 | Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance. | [
{
"docid": "13001323",
"title": "SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.",
"text": "Chronic feeding on high-calorie diets causes obesity and type 2 diabetes mellitus (T2DM), illnesses that affect hundreds of millions. Thus, understanding the pathways protecting against die... | [
{
"docid": "2481032",
"title": "Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues.",
"text": "Sirt1 is a NAD(+)-dependent class III deacetylase that functions as a cellular energy sensor. In addition to its well-characterized effects in peripheral tissues, emer... |
780 | Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis. | [
{
"docid": "8246922",
"title": "the Development of Autoimmune Myocarditis in Mice by an",
"text": "BACKGROUND Interleukin (IL)-12 exerts a potent proinflammatory effect by stimulating T-helper (Th) 1 responses. This effect is believed to be mediated primarily through the activation of STAT4 and subseque... | [
{
"docid": "40632104",
"title": "Dual role of the IL-12/IFN-gamma axis in the development of autoimmune myocarditis: induction by IL-12 and protection by IFN-gamma.",
"text": "IL-12 and IFN-gamma positively regulate each other and type 1 inflammatory responses, which are believed to cause tissue damage ... |
782 | Mice without IFN-γ or its receptor are highly susceptible to EAM induced with α-MyHC/CFA. | [
{
"docid": "8246922",
"title": "the Development of Autoimmune Myocarditis in Mice by an",
"text": "BACKGROUND Interleukin (IL)-12 exerts a potent proinflammatory effect by stimulating T-helper (Th) 1 responses. This effect is believed to be mediated primarily through the activation of STAT4 and subseque... | [
{
"docid": "39084565",
"title": "CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditis.",
"text": "Experimental autoimmune myocarditis (EAM) represents a Th17 T cell-mediated mouse model of postinflammatory heart disease. In BALB/c wild-type mice, EAM is a self-limiting... |
787 | Microcin J25 encourages nucleoside triphosphate (NTP) binding. | [
{
"docid": "4740447",
"title": "Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel.",
"text": "The antibacterial peptide microcin J25 (MccJ25) inhibits transcription by bacterial RNA polymerase (RNAP). Biochemical results indi... | [
{
"docid": "4393153",
"title": "Molecular basis of RNA-dependent RNA polymerase II activity",
"text": "RNA polymerase (Pol) II catalyses DNA-dependent RNA synthesis during gene transcription. There is, however, evidence that Pol II also possesses RNA-dependent RNA polymerase (RdRP) activity. Pol II can ... |
788 | Microcin J25 inhibits nucleoside triphosphate (NTP) binding. | [
{
"docid": "4740447",
"title": "Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel.",
"text": "The antibacterial peptide microcin J25 (MccJ25) inhibits transcription by bacterial RNA polymerase (RNAP). Biochemical results indi... | [
{
"docid": "4393153",
"title": "Molecular basis of RNA-dependent RNA polymerase II activity",
"text": "RNA polymerase (Pol) II catalyses DNA-dependent RNA synthesis during gene transcription. There is, however, evidence that Pol II also possesses RNA-dependent RNA polymerase (RdRP) activity. Pol II can ... |
789 | Microglia are an innate immune cell type of the central nervous system. | [
{
"docid": "15493354",
"title": "Sublime Microglia: Expanding Roles for the Guardians of the CNS",
"text": "Recent findings challenge the concept that microglia solely function in disease states in the central nervous system (CNS). Rather than simply reacting to CNS injury, infection, or pathology, emer... | [
{
"docid": "15889329",
"title": "A JOURNAL OF NEUROLOGY",
"text": "Brain glial cells, five times more prevalent than neurons, have recently received attention for their potential involvement in epileptic seizures. Microglia and astrocytes, associated with inflammatory innate immune responses, are respon... |
790 | Microglia are an innate immune cell type of the peripheral nervous system. | [
{
"docid": "15493354",
"title": "Sublime Microglia: Expanding Roles for the Guardians of the CNS",
"text": "Recent findings challenge the concept that microglia solely function in disease states in the central nervous system (CNS). Rather than simply reacting to CNS injury, infection, or pathology, emer... | [
{
"docid": "17438862",
"title": "Local neuroinflammation and the progression of Alzheimer’s disease",
"text": "Postmortem immunohistochemical studies have revealed a state of chronic inflammation limited to lesioned areas of brain in Alzheimer’s disease. Some key actors in this inflammation are activate... |
791 | Migraine with aura is associated with ischemic stroke. | [
{
"docid": "15984735",
"title": "Migraine and cardiovascular disease: systematic review and meta-analysis.",
"text": "OBJECTIVE To evaluate the association between migraine and cardiovascular disease, including stroke, myocardial infarction, and death due to cardiovascular disease. \n DESIGN Systemati... | [
{
"docid": "23785605",
"title": "Cardiovascular risk factors and migraine: the GEM population-based study.",
"text": "BACKGROUND Migraine, particularly with aura, is a risk factor for early-onset ischemic stroke. The underlying mechanisms are unknown, but may in part be due to migraineurs having an incr... |
792 | Misunderstandings between doctors and patients can lead to non-adherence. | [
{
"docid": "3610080",
"title": "Misunderstandings in prescribing decisions in general practice: qualitative study.",
"text": "OBJECTIVES To identify and describe misunderstandings between patients and doctors associated with prescribing decisions in general practice. \n DESIGN Qualitative study. \n ... | [
{
"docid": "13914633",
"title": "Time and Money: The True Costs of Health Care Utilization for Patients Receiving \"Free\" HIV/Tuberculosis Care and Treatment in Rural KwaZulu-Natal.",
"text": "BACKGROUND HIV and tuberculosis (TB) services are provided free of charge in many sub-Saharan African countrie... |
795 | Mitochondria play a major role in apoptosis. | [
{
"docid": "8551160",
"title": "Mitochondria: Dynamic Organelles in Disease, Aging, and Development",
"text": "Mitochondria are the primary energy-generating system in most eukaryotic cells. Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis. Given these well-est... | [
{
"docid": "8654183",
"title": "Bax translocation and mitochondrial fragmentation induced by Helicobacter pylori.",
"text": "BACKGROUND AND AIMS Previous in vitro and in vivo studies have revealed an association between Helicobacter pylori infection and apoptosis in gastric epithelial cells. Although in... |
797 | Mitochondria play a major role in energy production. | [
{
"docid": "8551160",
"title": "Mitochondria: Dynamic Organelles in Disease, Aging, and Development",
"text": "Mitochondria are the primary energy-generating system in most eukaryotic cells. Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis. Given these well-est... | [
{
"docid": "27693891",
"title": "Transcriptional integration of mitochondrial biogenesis.",
"text": "Gene regulatory factors encoded by the nuclear genome are essential for mitochondrial biogenesis and function. Some of these factors act exclusively within the mitochondria to regulate the control of mit... |
798 | Mitochondria play a trivial role in calcium homeostasis. | [
{
"docid": "8551160",
"title": "Mitochondria: Dynamic Organelles in Disease, Aging, and Development",
"text": "Mitochondria are the primary energy-generating system in most eukaryotic cells. Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis. Given these well-est... | [
{
"docid": "14767844",
"title": "Golli protein negatively regulates store depletion-induced calcium influx in T cells.",
"text": "Calcium influx is crucial for T cell activation and differentiation. The detailed regulation of this process remains unclear. We report here that golli protein, an alternativ... |
799 | Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD). | [
{
"docid": "5293024",
"title": "Life is sweet: candy consumption and longevity.",
"text": "Our attitude towards candy—“if it tastes that good, it can't be healthy”—betrays society's puritanical stance towards pleasure. Candy has been blamed for various ills, including hyperactivity in children; however,... | [
{
"docid": "7454794",
"title": "Statins in the primary prevention of cardiovascular disease",
"text": "Statins are widely used in the evidence-based lowering of cardiovascular disease (CVD) risk. The use of these drugs for secondary prevention of CVD is well founded, but their expanding use in primary p... |
801 | Monoclonal antibody targeting of N-cadherin encourages castration resistance. | [
{
"docid": "22180793",
"title": "Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance",
"text": "The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing... | [
{
"docid": "7177329",
"title": "Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape",
"text": "Neutralizing antibodies are likely to play a crucial part in a preventative HIV-1 vaccine. Although efforts to elicit broadly cross-neutralizing (BCN) antibodies by... |
802 | Monoclonal antibody targeting of N-cadherin encourages metastasis. | [
{
"docid": "22180793",
"title": "Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance",
"text": "The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing... | [
{
"docid": "3727986",
"title": "A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion",
"text": "Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables... |
803 | Monoclonal antibody targeting of N-cadherin inhibits castration resistance. | [
{
"docid": "22180793",
"title": "Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance",
"text": "The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing... | [
{
"docid": "25543207",
"title": "Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases.",
"text": "Platelet inhibitors are the mainstay treatment for patients with vascular diseases. The current 'gold standard' antiplatelet agent clopidogrel has se... |
804 | Monoclonal antibody targeting of N-cadherin inhibits growth. | [
{
"docid": "22180793",
"title": "Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance",
"text": "The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing... | [
{
"docid": "6550579",
"title": "A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy.",
"text": "Epidermal growth factor receptor (EGFR) and HER3 each form heterodimers with HER2 and have independently been implicated as key coreceptors that drive HER2-amplified bre... |
807 | Most termination events in Okazaki fragments are dictated by initiation patterns. | [
{
"docid": "36606083",
"title": "Quantitative, genome-wide analysis of eukaryotic replication initiation and termination.",
"text": "Many fundamental aspects of DNA replication, such as the exact locations where DNA synthesis is initiated and terminated, how frequently origins are used, and how fork pro... | [
{
"docid": "25787749",
"title": "G-quadruplexes significantly stimulate Pif1 helicase-catalyzed duplex DNA unwinding.",
"text": "The evolutionarily conserved G-quadruplexes (G4s) are faithfully inherited and serve a variety of cellular functions such as telomere maintenance, gene regulation, DNA replica... |
810 | Mouse models can be generated using "artificial spermatids." | [
{
"docid": "13513790",
"title": "Generation of Genetically Modified Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells",
"text": "Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has en... | [
{
"docid": "22186938",
"title": "Human artificial chromosomes containing chromosome 17 alphoid DNA maintain an active centromere in murine cells but are not stable.",
"text": "Human artificial chromosomes (HACs) are autonomous molecules that can function and segregate as normal chromosomes in human cell... |
812 | Mutant mice lacking SVCT2 have severely reduced ascorbic acid levels in both brain and adrenals. | [
{
"docid": "19799455",
"title": "Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival",
"text": "The only proven requirement for ascorbic acid (vitamin C) is in preventing scurvy, presumably because it is a cofactor for hydroxylases required fo... | [
{
"docid": "5107861",
"title": "Chronic variable stress activates hematopoietic stem cells",
"text": "Exposure to psychosocial stress is a risk factor for many diseases, including atherosclerosis. Although incompletely understood, interaction between the psyche and the immune system provides one potenti... |
813 | Mutations in G-Beta protein GNB1 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway. | [
{
"docid": "33387953",
"title": "Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance",
"text": "Activating mutations in genes encoding G protein α (Gα) subunits occur in 4-5% of all human cancers, but oncogenic alterations in Gβ subunits have not been defined. Her... | [
{
"docid": "22036571",
"title": "Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization.",
"text": "The AMP-activated protein kinase (AMPK) is a ubiquitous mammalian protein kinase important in the adaptation of cells to me... |
815 | Mutations in RIM1 decrease levels of IME1 RNA. | [
{
"docid": "8148304",
"title": "Molecular characterization of the yeast meiotic regulatory gene RIM1.",
"text": "In the yeast Saccharomyces cerevisiae, genetic studies suggest that the RIM1 gene encodes a positive regulator of meiosis. rim1 mutations cause reduced expression of IME1, which is required f... | [
{
"docid": "23604601",
"title": "Post-transcriptional regulation of IME1 determines initiation of meiosis in Saccharomyces cerevisiae.",
"text": "The IME1 gene of Saccharomyces cerevisiae is required for initiation of meiosis. Transcription of IME1 is detected under conditions which are known to induce ... |
816 | Mutations in RIM1 raise levels of IME1 RNA. | [
{
"docid": "8148304",
"title": "Molecular characterization of the yeast meiotic regulatory gene RIM1.",
"text": "In the yeast Saccharomyces cerevisiae, genetic studies suggest that the RIM1 gene encodes a positive regulator of meiosis. rim1 mutations cause reduced expression of IME1, which is required f... | [
{
"docid": "23604601",
"title": "Post-transcriptional regulation of IME1 determines initiation of meiosis in Saccharomyces cerevisiae.",
"text": "The IME1 gene of Saccharomyces cerevisiae is required for initiation of meiosis. Transcription of IME1 is detected under conditions which are known to induce ... |
817 | Myelin sheaths are lipid-rich cellular structures. | [
{
"docid": "17814815",
"title": "Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy",
"text": "We report a newly developed technique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and peripheral nerve that... | [
{
"docid": "27731651",
"title": "A view to a kill: the bacterial type VI secretion system.",
"text": "The bacterial type VI secretion system (T6SS) is an organelle that is structurally and mechanistically analogous to an intracellular membrane-attached contractile phage tail. Recent studies determined t... |
818 | Myelin sheaths play a role in action potential propagation. | [
{
"docid": "17814815",
"title": "Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy",
"text": "We report a newly developed technique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and peripheral nerve that... | [
{
"docid": "45487164",
"title": "A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulation.",
"text": "Caenorhabditis elegans oocytes, like those of most animals, arrest during meiotic prophase. Sperm promote the resumption of meiosis (maturation) and contraction of smooth muscle... |
822 | N348I mutations cause resistance to nevirapine. | [
{
"docid": "15319019",
"title": "N348I in the Connection Domain of HIV-1 Reverse Transcriptase Confers Zidovudine and Nevirapine Resistance",
"text": "Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymera... | [
{
"docid": "2319305",
"title": "N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation.",
"text": "Drug resistance-associated mutations in HIV-1 reverse transcriptase (RT) can affect the balance between polymerase and ribonu... |
825 | N348I mutations reduce resistance to nevirapine. | [
{
"docid": "15319019",
"title": "N348I in the Connection Domain of HIV-1 Reverse Transcriptase Confers Zidovudine and Nevirapine Resistance",
"text": "Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymera... | [
{
"docid": "2319305",
"title": "N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation.",
"text": "Drug resistance-associated mutations in HIV-1 reverse transcriptase (RT) can affect the balance between polymerase and ribonu... |
826 | NAC destabilizes NO to increase the effect of contrast agents on renal functions. | [
{
"docid": "4678846",
"title": "Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial.",
"text": "CONTEXT The antioxidant acetylcysteine prevents acute contrast nephrotoxicity in patients with impair... | [
{
"docid": "26025370",
"title": "Differential Effects of N-Acetylcysteine, Theophylline or Bicarbonate on Contrast-Induced Rat Renal Vasoconstriction",
"text": "Background: Vasoconstriction and reactive oxygen species (ROS) accumulation following contrast media (CM) injection are the key factors trigger... |
828 | NAC inhibits the generation of angiotensin-converting enzyme. | [
{
"docid": "4678846",
"title": "Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial.",
"text": "CONTEXT The antioxidant acetylcysteine prevents acute contrast nephrotoxicity in patients with impair... | [
{
"docid": "1759213",
"title": "The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: systematic review and meta-analysis",
"text": "OBJECTIVE To examine the safety of using aliskiren combined with agents used to block t... |
835 | NR5A2 does not play a role in development of endometrial tissues. | [
{
"docid": "15928989",
"title": "Liver receptor homolog-1 is essential for pregnancy",
"text": "Successful pregnancy requires coordination of an array of signals and factors from multiple tissues. One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism... | [
{
"docid": "1780819",
"title": "Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development",
"text": "BACKGROUND Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer developmen... |
838 | NR5A2 is important in reverse cholesterol transport in humans. | [
{
"docid": "15928989",
"title": "Liver receptor homolog-1 is essential for pregnancy",
"text": "Successful pregnancy requires coordination of an array of signals and factors from multiple tissues. One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism... | [
{
"docid": "23286603",
"title": "Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.",
"text": "Liver X receptors (LXR) are oxysterol-activated nuclear receptors that play a central role in reverse cholesterol transport through up-reg... |
840 | Natriuretic peptides increase susceptibility to diabetes. | [
{
"docid": "15663829",
"title": "Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies",
"text": "BACKGROUND Genetic and epidemiological evidence suggests an inverse association between B-type natriuretic peptide (BNP) lev... | [
{
"docid": "3912660",
"title": "Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia.",
"text": "OBJECTIVE Corin is a serine protease that converts pro-atrial natriuretic peptide (pro-ANP) to atrial natriuretic p... |
841 | Natriuretic peptides protect against diabetes. | [
{
"docid": "15663829",
"title": "Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies",
"text": "BACKGROUND Genetic and epidemiological evidence suggests an inverse association between B-type natriuretic peptide (BNP) lev... | [
{
"docid": "3912660",
"title": "Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia.",
"text": "OBJECTIVE Corin is a serine protease that converts pro-atrial natriuretic peptide (pro-ANP) to atrial natriuretic p... |
844 | Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO. | [
{
"docid": "17741440",
"title": "Netting neutrophils in autoimmune small-vessel vasculitis",
"text": "Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular tr... | [
{
"docid": "11328820",
"title": "NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.",
"text": "The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein anti... |
846 | Neutrophils produce IL-1β in response to large particles. | [
{
"docid": "22696649",
"title": "Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size",
"text": "How the number of immune cells recruited to sites of infection is determined and adjusted to differences in the cellular stoichiometry between host and pathogen is u... | [
{
"docid": "2692522",
"title": "Gout-associated uric acid crystals activate the NALP3 inflammasome",
"text": "Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) cr... |
848 | Nigerian physicians constitue the largest component of sub-Saharan Africa-trained physicians in the United States. | [
{
"docid": "14500725",
"title": "Physician Emigration from Sub-Saharan Africa to the United States: Analysis of the 2011 AMA Physician Masterfile",
"text": "BACKGROUND The large-scale emigration of physicians from sub-Saharan Africa (SSA) to high-income nations is a serious development concern. Our obje... | [
{
"docid": "3662510",
"title": "The financial cost of doctors emigrating from sub-Saharan Africa: human capital analysis",
"text": "OBJECTIVE To estimate the lost investment of domestically educated doctors migrating from sub-Saharan African countries to Australia, Canada, the United Kingdom, and the Un... |
853 | Nonhuman primates are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos. | [
{
"docid": "24922825",
"title": "A chikungunya fever vaccine utilizing an insect-specific virus platform",
"text": "Traditionally, vaccine development involves tradeoffs between immunogenicity and safety. Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety when co... | [
{
"docid": "152245",
"title": "Effects of an opal termination codon preceding the nsP4 gene sequence in the O'Nyong-Nyong virus genome on Anopheles gambiae infectivity.",
"text": "The genomic RNA of an alphavirus encodes four different nonstructural proteins, nsP1, nsP2, nsP3, and nsP4. The polyprotein ... |
854 | Nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime. | [
{
"docid": "12206390",
"title": "Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study.",
"text": "CONTEXT The long-term risk for developing hypertension is best described by the lifetime risk statistic. The lifetime risk for hypertension and trends ... | [
{
"docid": "4506414",
"title": "Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people",
"text": "BACKGROUND The associations of blood pressure with the different manifestations of incident cardiovascu... |
855 | Noninvasive positive pressure ventilation is not predictive of acute respiratory failure after solid organ transplantation. | [
{
"docid": "8190282",
"title": "Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial.",
"text": "CONTEXT Noninvasive ventilation (NIV) has been associated with lower rates of endotracheal intubation in populations of pa... | [
{
"docid": "40867854",
"title": "Acute respiratory failure in patients with severe community-acquired pneumonia: a prospective randomized evaluation of noninvasive ventilation.",
"text": "In uncontrolled studies, noninvasive positive pressure ventilation (NPPV) was found useful in avoiding endotracheal ... |
856 | Nonsteroidal antinflammatory drugs are ineffective as cancer treatments. | [
{
"docid": "43334921",
"title": "Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.",
"text": "IMPORTANCE Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer. \n OBJECTIVE To identify ... | [
{
"docid": "6407356",
"title": "Coxibs and other nonsteroidal anti-inflammatory drugs in animal models of cancer chemoprevention.",
"text": "Coxibs, including celecoxib, and other nonsteroidal anti-inflammatory drugs (NSAID), including aspirin, are among the most promising cancer chemopreventive agents ... |
857 | Nonsteroidal antinflammatory drugs show potential anticancer indications. | [
{
"docid": "43334921",
"title": "Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.",
"text": "IMPORTANCE Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer. \n OBJECTIVE To identify ... | [
{
"docid": "3866315",
"title": "Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing",
"text": "Aspirin therapy inhibits prostaglandin biosynthesis without d... |
858 | Normal expression of RUNX1 causes tumorsupressing effects. | [
{
"docid": "1982286",
"title": "Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL",
"text": "The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse... | [
{
"docid": "12315072",
"title": "Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.",
"text": "At the cellular level, development progresses through successive regulatory states, ... |
860 | Normal granulomas form in the absence of TNF in Zebrafish. | [
{
"docid": "16066726",
"title": "Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death.",
"text": "Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granuloma... | [
{
"docid": "24707550",
"title": "A systemic granulomatous response to Schistosoma mansoni eggs alters responsiveness of bone-marrow-derived macrophages to Toll-like receptor agonists.",
"text": "Macrophages play a pivotal role in innate and acquired immune responses to Schistosoma mansoni. Classical (M1... |
861 | Normal granulomas form in the presence of TNF in Zebrafish. | [
{
"docid": "16066726",
"title": "Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death.",
"text": "Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granuloma... | [
{
"docid": "24707550",
"title": "A systemic granulomatous response to Schistosoma mansoni eggs alters responsiveness of bone-marrow-derived macrophages to Toll-like receptor agonists.",
"text": "Macrophages play a pivotal role in innate and acquired immune responses to Schistosoma mansoni. Classical (M1... |
863 | Notch signaling occurs between tumor cells and stromal cells. | [
{
"docid": "20568364",
"title": "Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling.",
"text": "While significant progress has been made in understanding the induction of tumor vasculature by secreted angiogenic factors, little is known regard... | [
{
"docid": "16086778",
"title": "Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis",
"text": "The biological antagonism between Notch and Numb controls the proliferative/differentiative balance in development and homeostasis. Although altered Notch signaling has b... |
866 | Nuclear transfer from adult human fibroblasts to human oocytes can give rise to blastocysts containing expandable pluripotent cells. | [
{
"docid": "37822406",
"title": "Human somatic cell nuclear transfer using adult cells.",
"text": "Derivation of patient-specific human pluripotent stem cells via somatic cell nuclear transfer (SCNT) has the potential for applications in a range of therapeutic contexts. However, successful SCNT with hum... | [
{
"docid": "4457834",
"title": "Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells",
"text": "The transfer of somatic cell nuclei into oocytes can give rise to pluripotent stem cells that are consistently equivalent to embryonic stem cells, holding promis... |
867 | Oat tolerant coeliac patients may have oat specific inflammatory cells in their small bowel mucosa. | [
{
"docid": "14340571",
"title": "The Molecular Basis for Oat Intolerance in Patients with Celiac Disease",
"text": "Background Celiac disease is a small intestinal inflammatory disorder characterized by malabsorption, nutrient deficiency, and a range of clinical manifestations. It is caused by an inapp... | [
{
"docid": "10675756",
"title": "Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis.",
"text": "BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG autoantibodies. It is... |
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