query_id stringlengths 1 4 | query stringlengths 26 249 | positive_passages listlengths 1 5 | negative_passages listlengths 16 20 |
|---|---|---|---|
509 | Hematopoietic Stem Cell purification reaches purity rates above 90%. | [
{
"docid": "13980338",
"title": "Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations",
"text": "Heterogeneity within the self-renewal durability of adult hematopoietic stem cells (HSCs) challenges our understanding of the molecular framework u... | [
{
"docid": "104143831",
"title": "Utilization of Desalination Brine for Sodium Hydroxide Production: Technologies, Engineering Principles, Recovery Limits, and Future Directions",
"text": "As global desalination capacity continues its rapid growth, the impetus for reducing the adverse environmental impa... |
515 | High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD). | [
{
"docid": "29564505",
"title": "Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease.",
"text": "IMPORTANCE Exacerbations of respiratory symptoms in chronic obstructive pulmonary disease (COPD) have profound and long-lasting adverse effects on patients. \n OBJECTIVE To t... | [
{
"docid": "20109325",
"title": "Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.",
"text": "Chronic obstructive pulmonary disease (COPD) is a global health problem, and since 2001, the Global Initiative for Chronic Obstructi... |
523 | Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are negatively correlated with cardiovascular events in humans. | [
{
"docid": "14803797",
"title": "Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis",
"text": "Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trime... | [
{
"docid": "6793674",
"title": "Circulating trimethylamine N‐oxide and the risk of cardiovascular diseases: a systematic review and meta‐analysis of 11 prospective cohort studies",
"text": "Circulating trimethylamine N-oxide (TMAO), a canonical metabolite from gut flora, has been related to the risk of ... |
524 | Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans. | [
{
"docid": "14803797",
"title": "Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis",
"text": "Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trime... | [
{
"docid": "6793674",
"title": "Circulating trimethylamine N‐oxide and the risk of cardiovascular diseases: a systematic review and meta‐analysis of 11 prospective cohort studies",
"text": "Circulating trimethylamine N-oxide (TMAO), a canonical metabolite from gut flora, has been related to the risk of ... |
526 | Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress. | [
{
"docid": "3863543",
"title": "Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.",
"text": "Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system, but the underlying mole... | [
{
"docid": "1617327",
"title": "Bone progenitor dysfunction induces myelodysplasia and secondary leukemia",
"text": "Mesenchymal cells contribute to the 'stroma' of most normal and malignant tissues, with specific mesenchymal cells participating in the regulatory niches of stem cells. By examining how m... |
529 | Human embryonic stem cells give rise to cell types from all three embryonic germ layers. | [
{
"docid": "10546779",
"title": "Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst.",
"text": "Somatic cell nuclear transfer (SCNT) technology has recently been used to generate animals with a common genetic composition. In this study, we report the derivation of ... | [
{
"docid": "3360421",
"title": "Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro",
"text": "We describe the derivation of pluripotent embryonic stem (ES) cells from human blastocysts. Two diploid ES cell lines have been cultivated in vitro for extended periods while mai... |
530 | Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers. | [
{
"docid": "10546779",
"title": "Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst.",
"text": "Somatic cell nuclear transfer (SCNT) technology has recently been used to generate animals with a common genetic composition. In this study, we report the derivation of ... | [
{
"docid": "3360421",
"title": "Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro",
"text": "We describe the derivation of pluripotent embryonic stem (ES) cells from human blastocysts. Two diploid ES cell lines have been cultivated in vitro for extended periods while mai... |
531 | Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers. | [
{
"docid": "10546779",
"title": "Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst.",
"text": "Somatic cell nuclear transfer (SCNT) technology has recently been used to generate animals with a common genetic composition. In this study, we report the derivation of ... | [
{
"docid": "3360421",
"title": "Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro",
"text": "We describe the derivation of pluripotent embryonic stem (ES) cells from human blastocysts. Two diploid ES cell lines have been cultivated in vitro for extended periods while mai... |
537 | Hypocretin neurones suppress panicprone state in rats. | [
{
"docid": "16056514",
"title": "A KEY ROLE FOR OREXIN IN PANIC ANXIETY",
"text": "Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central gamma-aminobutyric acid (GABA) activity as well as marked i... | [
{
"docid": "4447055",
"title": "Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury",
"text": "Contusive spinal cord injury leads to a variety of disabilities owing to limited neuronal regeneration and functional plasticity. It is well established that an upregulation... |
541 | Hypothalamic glutamate neurotransmission is unrelated to energy balance. | [
{
"docid": "45154987",
"title": "Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation.",
"text": "The melanocortin receptor 4 (MC4R) is a well-established mediator of body weight homeostasis. However, the neurotransmitter(s) that mediate MC4R function rema... | [
{
"docid": "17150648",
"title": "Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes.",
"text": "Glial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy balance. Leptin, a k... |
542 | IFI16 impedes STING phosphorylation and translocation, resulting in reduced activation of STING. | [
{
"docid": "19688024",
"title": "IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes",
"text": "Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second ... | [
{
"docid": "41337677",
"title": "The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells",
"text": "The recognition of pathogenic DNA is important to the initiation of antiviral responses. Here we report the identification of DDX41, a member of the DEXDc family of he... |
545 | IFIT1 speeds viral replication by allowing for the proliferation of mis-capped viral RNAs. | [
{
"docid": "24221369",
"title": "A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.",
"text": "The cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to most RNA viruses by detecting viral 5'-triphosphorylated RNA (ppp... | [
{
"docid": "1970884",
"title": "Rational design of a flavivirus vaccine by abolishing viral RNA 2'-O methylation.",
"text": "Viruses that replicate in the cytoplasm cannot access the host nuclear capping machinery. These viruses have evolved viral methyltransferase(s) to methylate N-7 and 2'-O cap of th... |
547 | IL-10 production by monocytes inhibits CD4 + T cell response. | [
{
"docid": "10648422",
"title": "Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection",
"text": "Viral replication and microbial translocation from the gut to the blood during HIV infection lead to hyperimmune activation, which contributes... | [
{
"docid": "8639034",
"title": "Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production.",
"text": "IL-10 gene transcription and IL-10 protein production was assessed in both type 1 (Th1) and type... |
548 | IL-6 signaling plays a major role in atherosclerotic cardiovascular disease. | [
{
"docid": "18199839",
"title": "Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies",
"text": "BACKGROUND Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (I... | [
{
"docid": "9334631",
"title": "C-reactive protein decreases interleukin-10 secretion in activated human monocyte-derived macrophages via inhibition of cyclic AMP production.",
"text": "OBJECTIVE C-Reactive protein (CRP), a cardiovascular risk marker, could also participate in atherosclerosis. Atheroscl... |
550 | ITAM phosphorylation allows for the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR). | [
{
"docid": "33499189",
"title": "Full activation of the T cell receptor requires both clustering and conformational changes at CD3.",
"text": "T cell receptor (TCR-CD3) triggering involves both receptor clustering and conformational changes at the cytoplasmic tails of the CD3 subunits. The mechanism by ... | [
{
"docid": "8903143",
"title": "Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.",
"text": "The T-cell receptor (TCR) consists of a TCRαβ heterodimer, a TCRζ homodimer, and CD3γε and CD3δε heterodimers. The precise mechanism of T-cell trigge... |
553 | IgA plasma cells that are specific for transglutaminase 2 are scarce in the duodenal mucosa of celiac disease patients when the disease is active. | [
{
"docid": "1471041",
"title": "High abundance of plasma cells secreting transglutaminase 2–specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions",
"text": "Celiac disease is an immune-mediated disorder in which mucosal autoantibodies to the enzyme transglut... | [
{
"docid": "21060008",
"title": "Celiac disease screening by immunochromatographic visual assays: results of a multicenter study.",
"text": "OBJECTIVE To assay the efficiency for celiac disease (CD) screening of 2 immunochromatographic visual stick assays based on human recombinant tissue transglutamina... |
555 | Immune complex triggered cell death leads to extracellular release of nuclear DNA. | [
{
"docid": "1049501",
"title": "Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease",
"text": "Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are generated and their roles in sterile inflammatio... | [
{
"docid": "43054703",
"title": "A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus.",
"text": "Neutrophil extracellular traps (NETs) are webs of DNA covered with antimicrobial molecules that constitute a newly described killing mechanism in i... |
557 | Immune complex triggered cell death leads to sequestration of oxidized mitochondrial DNA. | [
{
"docid": "1049501",
"title": "Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease",
"text": "Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are generated and their roles in sterile inflammatio... | [
{
"docid": "42873134",
"title": "Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.",
"text": "Type 1 and type 2 diabetes are characterized by progressive beta-cell failure. Apoptosis is probably the main form of beta-cell death in both forms of t... |
559 | Immune responses in immune cells are geographically segregated. | [
{
"docid": "3475317",
"title": "Inflammatory signaling in human Tuberculosis granulomas is spatially organized",
"text": "Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in T... | [
{
"docid": "10607877",
"title": "Mechanical modulation of receptor-ligand interactions at cell-cell interfaces.",
"text": "Cell surface receptors have been extensively studied because they initiate and regulate signal transduction cascades leading to a variety of functional cellular outcomes. An importa... |
562 | Improvements in OER catalysts show stable activity over several hundred hours. | [
{
"docid": "20101846",
"title": "Homogeneously dispersed multimetal oxygen-evolving catalysts",
"text": "Earth-abundant first-row (3d) transition metal–based catalysts have been developed for the oxygen-evolution reaction (OER); however, they operate at overpotentials substantially above thermodynamic r... | [
{
"docid": "14711483",
"title": "Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease.",
"text": "CONTEXT Vaso-occlusion is central to the painful crises and acute and chronic organ damage in sickle cell disease. Abnormal nitric ox... |
563 | In British Men, haplogroup I decreases risk of cardiovascular disease. | [
{
"docid": "2867345",
"title": "Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome",
"text": "BACKGROUND A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women. We explored t... | [
{
"docid": "5698494",
"title": "The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials",
"text": "OBJECTIVES To investigate whether statins reduce all cause mortality and major coronary and cerebrov... |
564 | In British Men, haplogroup I increases risk of cardiovascular disease by 50%. | [
{
"docid": "2867345",
"title": "Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome",
"text": "BACKGROUND A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women. We explored t... | [
{
"docid": "29253460",
"title": "Sex-related differences in the presentation, treatment and outcomes among patients with acute coronary syndromes: the Global Registry of Acute Coronary Events.",
"text": "OBJECTIVE To assess whether sex differences exist in the angiographic severity, management and outco... |
565 | In S. cerevisiae, the absence of RNA surveillance pathways causes sensitivity to high iron conditions. | [
{
"docid": "16120395",
"title": "Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae.",
"text": "Tight regulation of the expression of mRNAs encoding iron uptake proteins is essential to control iron homeostasis and avoid intracell... | [
{
"docid": "8247597",
"title": "Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect",
"text": "Mutations and deletions in the mitochondrial genome (mtDNA), as well as instability of the nuclear genome, are involved in multiple human diseases. Here, we report t... |
566 | In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions. | [
{
"docid": "16120395",
"title": "Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae.",
"text": "Tight regulation of the expression of mRNAs encoding iron uptake proteins is essential to control iron homeostasis and avoid intracell... | [
{
"docid": "8247597",
"title": "Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect",
"text": "Mutations and deletions in the mitochondrial genome (mtDNA), as well as instability of the nuclear genome, are involved in multiple human diseases. Here, we report t... |
568 | In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibits self-renewal of the mouse embryonic stem cells. | [
{
"docid": "23418635",
"title": "Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells",
"text": "Pluripotent stem cells exist in naive and primed states, epitomized by mouse embryonic stem cells (ESCs) and the developmentally more advanced epiblast stem cells (EpiS... | [
{
"docid": "6441369",
"title": "MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency.",
"text": "The interconversion between naive and primed pluripotent states is accompanied by drastic epigenetic rearrangements. However, it is unclear whether intrinsic epigenetic events can drive repro... |
570 | In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma. | [
{
"docid": "20333864",
"title": "Regulation of in situ to invasive breast carcinoma transition.",
"text": "The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myoepithelial cells and fibroblas... | [
{
"docid": "24249915",
"title": "Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model.",
"text": "To gain insights into the possible role of oestrogen receptor (ER) beta in breast carcinogenesis, immuno... |
571 | In breast cancer, the loss of myoepithelial cells slows the transition of ductal carcinoma in situ to invasive carcinoma. | [
{
"docid": "20333864",
"title": "Regulation of in situ to invasive breast carcinoma transition.",
"text": "The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myoepithelial cells and fibroblas... | [
{
"docid": "24249915",
"title": "Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model.",
"text": "To gain insights into the possible role of oestrogen receptor (ER) beta in breast carcinogenesis, immuno... |
572 | In chronic viral infections or tumors, peptides that selectively inhibit PTPRS can be utilized to boost insufficient activity of pDCs. | [
{
"docid": "4447055",
"title": "Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury",
"text": "Contusive spinal cord injury leads to a variety of disabilities owing to limited neuronal regeneration and functional plasticity. It is well established that an upregulation... | [
{
"docid": "8596357",
"title": "Porcine circovirus type 2 DNA influences cytoskeleton rearrangements in plasmacytoid and monocyte-derived dendritic cells.",
"text": "Functional disruption of dendritic cells (DC) is an important strategy for viral pathogens to evade host defences. In this context, porcin... |
573 | In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy is very common. | [
{
"docid": "10300888",
"title": "Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts",
"text": "Whereas domestication of livestock, pets, and crops is well documented, it is still unclear to what extent microbes associated with the production of food have also undergone human selection ... | [
{
"docid": "23664875",
"title": "The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae.",
"text": "Termination of replication forks at the natural termini of the rDNA of Saccharomyces cerevisiae is controlled in a sequence-specific ... |
574 | In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently. | [
{
"docid": "10300888",
"title": "Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts",
"text": "Whereas domestication of livestock, pets, and crops is well documented, it is still unclear to what extent microbes associated with the production of food have also undergone human selection ... | [
{
"docid": "7643848",
"title": "Membrane topology of the 60-kDa Oxa1p homologue from Escherichia coli.",
"text": "We have characterized the membrane topology of a 60-kDa inner membrane protein from Escherichia coli that is homologous to the recently identified Oxa1p protein in Saccharomyces cerevisiae m... |
576 | In melanoma, anti-CTLA-4 treatment reinvigorates exhausted PD-1+Eomes+CD8 T cells. | [
{
"docid": "4468861",
"title": "Radiation and Dual Checkpoint Blockade Activates Non-Redundant Immune Mechanisms in Cancer",
"text": "Immune checkpoint inhibitors result in impressive clinical responses, but optimal results will require combination with each other and other therapies. This raises fundam... | [
{
"docid": "15128866",
"title": "CD4+ T cell-mediated cytotoxicity eliminates primary tumor cells in metastatic melanoma through high MHC class II expression and can be enhanced by inhibitory receptor blockade",
"text": "Metastatic melanoma is a rapidly progressing disease with high mortality rate and l... |
579 | In patients with congenital heart defects, β-blockers significantly improve clinical heart failure outcomes. | [
{
"docid": "34139429",
"title": "Carvedilol for children and adolescents with heart failure: a randomized controlled trial.",
"text": "CONTEXT Although beta-blockers improve symptoms and survival in adults with heart failure, little is known about these medications in children and adolescents. \n OBJE... | [
{
"docid": "9622258",
"title": "Intracoronary autologous cardiac progenitor cell transfer in patients with hypoplastic left heart syndrome: the TICAP prospective phase 1 controlled trial.",
"text": "RATIONALE Hypoplastic left heart syndrome (HLHS) remains a lethal congenital cardiac defect. Recent studi... |
580 | In pediatric tissue, most T cells are naive T cell emigrants from the thymus. | [
{
"docid": "23460562",
"title": "Early life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues",
"text": "It is unclear how the immune response in early life becomes appropriately stimulated to provide protection while also avoiding excessive act... | [
{
"docid": "1336292",
"title": "Immunosuppressant FTY720 inhibits thymocyte emigration.",
"text": "One major role of the thymus is to provide the peripheral immune system with mature T cells, but the mechanisms involving the cellular export are not fully understood. In this study, we examined the abilit... |
582 | In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus. | [
{
"docid": "14260013",
"title": "Prevention of Rectal SHIV Transmission in Macaques by Daily or Intermittent Prophylaxis with Emtricitabine and Tenofovir ",
"text": "BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit it... | [
{
"docid": "708425",
"title": "Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection.",
"text": "HIV continues to spread globally, mainly through sexual contact. Despite advances in treatment and care, preventing transmission with vaccines or microbicides has proven dif... |
584 | In rhesus macaques, daily subcutaneous injections of tenofovir protects against rectally transmitted simian-human immunodeficiency virus. | [
{
"docid": "14260013",
"title": "Prevention of Rectal SHIV Transmission in Macaques by Daily or Intermittent Prophylaxis with Emtricitabine and Tenofovir ",
"text": "BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit it... | [
{
"docid": "708425",
"title": "Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection.",
"text": "HIV continues to spread globally, mainly through sexual contact. Despite advances in treatment and care, preventing transmission with vaccines or microbicides has proven dif... |
585 | In the UK, drowning affects boys and girls equally. | [
{
"docid": "42291761",
"title": "Preventing deaths by drowning in children in the United Kingdom: have we made progress in 10 years? Population based incidence study.",
"text": "Detailed information on drowning in children is not routinely collected by offices of national statistics. Few studies have be... | [
{
"docid": "8428935",
"title": "Relationship of physical activity and television watching with body weight and level of fatness among children: results from the Third National Health and Nutrition Examination Survey.",
"text": "CONTEXT Physical inactivity contributes to weight gain in adults, but whethe... |
588 | In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers. | [
{
"docid": "16999023",
"title": "Cell Stem Cell Article In Vivo Fate Analysis Reveals the Multipotent and Self-Renewal Capacities of Sox2 + Neural Stem Cells in the Adult Hippocampus",
"text": "To characterize the properties of adult neural stem cells (NSCs), we generated and analyzed Sox2-GFP transgeni... | [
{
"docid": "7142113",
"title": "Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter.",
"text": "Fucci technology makes possible the distinction between live cells in the G(1) and S/G(2)/M phases by dual-color imaging. This technology relies upon ubiquitylation-m... |
590 | In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events. | [
{
"docid": "10984005",
"title": "ADHD medications and risk of serious cardiovascular events in young and middle-aged adults.",
"text": "CONTEXT More than 1.5 million US adults use stimulants and other medications labeled for treatment of attention-deficit/hyperactivity disorder (ADHD). These agents can ... | [
{
"docid": "25451374",
"title": "Cardiovascular risk and events in 17 low-, middle-, and high-income countries.",
"text": "BACKGROUND More than 80% of deaths from cardiovascular disease are estimated to occur in low-income and middle-income countries, but the reasons are unknown. \n METHODS We enrolle... |
591 | Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia. | [
{
"docid": "14682243",
"title": "Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study",
"text": "BACKGROUND Results of the few cohort studies from countries with low incomes or mi... | [
{
"docid": "32463364",
"title": "Antihypertensive classes, cognitive decline and incidence of dementia: a network meta-analysis.",
"text": "OBJECTIVES Prevention of cognitive decline and dementia with blood pressure lowering treatments has shown inconsistent results. We compared the effects of different... |
592 | Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia. | [
{
"docid": "14682243",
"title": "Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study",
"text": "BACKGROUND Results of the few cohort studies from countries with low incomes or mi... | [
{
"docid": "32463364",
"title": "Antihypertensive classes, cognitive decline and incidence of dementia: a network meta-analysis.",
"text": "OBJECTIVES Prevention of cognitive decline and dementia with blood pressure lowering treatments has shown inconsistent results. We compared the effects of different... |
594 | Incidence of heart failure increased by 10% in women since 1979. | [
{
"docid": "19675911",
"title": "Trends in heart failure incidence and survival in a community-based population.",
"text": "CONTEXT The epidemic of heart failure has yet to be fully investigated, and data on incidence, survival, and sex-specific temporal trends in community-based populations are limited... | [
{
"docid": "31889025",
"title": "The progression from hypertension to congestive heart failure.",
"text": "OBJECTIVES - To study the relative and population-attributable risks of hypertension for the development of congestive heart failure (CHF), to assess the time course of progression from hypertensio... |
595 | Incidence of sepsis has fallen substantially from 2009 to 2014. | [
{
"docid": "4824840",
"title": "Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014",
"text": "Importance Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from cl... | [
{
"docid": "3776162",
"title": "Epidemiology of sepsis and septic shock in critical care units: comparison between sepsis-2 and sepsis-3 populations using a national critical care database",
"text": "Background New sepsis and septic shock definitions could change the epidemiology of sepsis because of di... |
600 | Including pharmacists in rounding teams does not alter the incidence of adverse drug events (ADEs). | [
{
"docid": "12258338",
"title": "Pharmacist participation on physician rounds and adverse drug events in the intensive care unit.",
"text": "CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug cost... | [
{
"docid": "42404093",
"title": "Incidence of adverse drug events and potential adverse drug events. Implications for prevention. ADE Prevention Study Group.",
"text": "OBJECTIVES To assess incidence and preventability of adverse drug events (ADEs) and potential ADEs. To analyze preventable events to de... |
601 | Including pharmacists in rounding teams reduces the incidence of adverse drug events (ADEs). | [
{
"docid": "12258338",
"title": "Pharmacist participation on physician rounds and adverse drug events in the intensive care unit.",
"text": "CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug cost... | [
{
"docid": "42404093",
"title": "Incidence of adverse drug events and potential adverse drug events. Implications for prevention. ADE Prevention Study Group.",
"text": "OBJECTIVES To assess incidence and preventability of adverse drug events (ADEs) and potential ADEs. To analyze preventable events to de... |
602 | Increase of p62 in prostate tumor stroma results in defective autophagy. | [
{
"docid": "3701541",
"title": "p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.",
"text": "Hepatic stellate cells (HSCs) play critical roles in liver fibrosis and hepatocellular carcinoma (HCC). Vitamin D receptor (VDR) activation in HSCs ... | [
{
"docid": "26735905",
"title": "Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis.",
"text": "The tumor microenvironment plays a critical role in cancer progression, but the precise mechanisms by which stromal cells influence the epithel... |
603 | Increased LDL receptors plays a role in the reduction of plasma Lp(a). | [
{
"docid": "6540064",
"title": "Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans",
"text": "BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipopro... | [
{
"docid": "33118292",
"title": "Optimal therapy for reduction of lipoprotein(a).",
"text": "WHAT IS KNOWN AND OBJECTIVE There is a growing body of experimental and clinical evidence for the atherogenic and pro-thrombotic potential of Lipoprotein(a) [Lp(a)], as well as for its causative role in coronary... |
606 | Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE. | [
{
"docid": "712078",
"title": "Pharmacological correction of a defect in PPARγ signaling ameliorates disease severity in Cftr-deficient mice",
"text": "Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (encoded by Cftr) that impair its role as an apical ch... | [
{
"docid": "20732789",
"title": "Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase products.",
"text": "Cigarette smoke is the main cause of chronic obstructive pulmonary disease (COPD), where it can contribute to the observed airway inflammati... |
607 | Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm. | [
{
"docid": "4506414",
"title": "Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people",
"text": "BACKGROUND The associations of blood pressure with the different manifestations of incident cardiovascu... | [
{
"docid": "30058568",
"title": "Improved prognosis of thoracic aortic aneurysms: a population-based study.",
"text": "CONTEXT Managing thoracic aortic aneurysms identified incidentally by increased use of computed tomography, echocardiography, and magnetic resonance imaging is problematic, especially i... |
609 | Increased flux of microbial products provokes immune responses. | [
{
"docid": "40096222",
"title": "Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis.",
"text": "Mice lacking junctional adhesion molecule A (JAM-A, encoded by F11r) exhibit enhanced intestinal epithelial permeability, bacterial translocation, and el... | [
{
"docid": "17023584",
"title": "Current knowledge and future directions of TLR and NOD signaling in sepsis",
"text": "The incidence of sepsis is increasing over time, along with an increased risk of dying from the condition. Sepsis care costs billions annually in the United States. Death from sepsis is... |
610 | Increased flux of microbial products suppresses immune responses. | [
{
"docid": "40096222",
"title": "Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis.",
"text": "Mice lacking junctional adhesion molecule A (JAM-A, encoded by F11r) exhibit enhanced intestinal epithelial permeability, bacterial translocation, and el... | [
{
"docid": "14644164",
"title": "TLR-activated B cells suppress T cell-mediated autoimmunity.",
"text": "TLR sense microbial infections, and control activation of immune responses. Dendritic cells, macrophages, and B lymphocytes express TLR and the TLR-signaling adaptor protein MyD88. The impact of TLR-... |
611 | Increased lipolysis leads to higher P38 phosphorylation in adipose tissue. | [
{
"docid": "32408470",
"title": "Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo",
"text": "Cigarette smoking promotes body weight reduction in humans while paradoxically also promoting insulin resistance (IR) and hyperinsulinemia. However, the mechanisms ... | [
{
"docid": "970012",
"title": "Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis",
"text": "Molecular mechanisms underlying the cold-associated high cardiovascular risk remain unknown. Here, we show that the cold-triggered food-intake-independent lipolysis... |
612 | Increased microtubule acetylation exacerbates LRRK2 Roc-COR domain mutation induced locomotor deficits. | [
{
"docid": "9638032",
"title": "Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations",
"text": "Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease. LRRK2 is a multifunctional prote... | [
{
"docid": "21598000",
"title": "Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex.",
"text": "Plus-end tracking proteins, such as EB1 and the dynein/dynactin complex, regulate microtubule dynamics. These proteins are thought to stabilize microtubules by formin... |
614 | Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations. | [
{
"docid": "9638032",
"title": "Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations",
"text": "Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease. LRRK2 is a multifunctional prote... | [
{
"docid": "33911859",
"title": "Mutant dynactin in motor neuron disease",
"text": "Impaired axonal transport in motor neurons has been proposed as a mechanism for neuronal degeneration in motor neuron disease. Here we show linkage of a lower motor neuron disease to a region of 4 Mb at chromosome 2p13. ... |
615 | Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations. | [
{
"docid": "9638032",
"title": "Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations",
"text": "Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease. LRRK2 is a multifunctional prote... | [
{
"docid": "33911859",
"title": "Mutant dynactin in motor neuron disease",
"text": "Impaired axonal transport in motor neurons has been proposed as a mechanism for neuronal degeneration in motor neuron disease. Here we show linkage of a lower motor neuron disease to a region of 4 Mb at chromosome 2p13. ... |
616 | Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates. | [
{
"docid": "18670",
"title": "The DNA Methylome of Human Peripheral Blood Mononuclear Cells",
"text": "DNA methylation plays an important role in biological processes in human health and disease. Recent technological advances allow unbiased whole-genome DNA methylation (methylome) analysis to be carried... | [
{
"docid": "17911973",
"title": "Natural Mutagenesis of Human Genomes by Endogenous Retrotransposons",
"text": "Two abundant classes of mobile elements, namely Alu and L1 elements, continue to generate new retrotransposon insertions in human genomes. Estimates suggest that these elements have generated ... |
617 | Increased mobility of retrotransposons is assosciated with mutation and higher tumorigenesis rates. | [
{
"docid": "18670",
"title": "The DNA Methylome of Human Peripheral Blood Mononuclear Cells",
"text": "DNA methylation plays an important role in biological processes in human health and disease. Recent technological advances allow unbiased whole-genome DNA methylation (methylome) analysis to be carried... | [
{
"docid": "17911973",
"title": "Natural Mutagenesis of Human Genomes by Endogenous Retrotransposons",
"text": "Two abundant classes of mobile elements, namely Alu and L1 elements, continue to generate new retrotransposon insertions in human genomes. Estimates suggest that these elements have generated ... |
618 | Increased purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels. | [
{
"docid": "6836086",
"title": "Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli",
"text": "Gram-negative bacteria have an outer membrane (OM) that functions as a barrier to protect the cell from toxic compounds such as antibiotics and detergents. The... | [
{
"docid": "24541180",
"title": "Isolation of intact nuclei of high purity from mouse liver.",
"text": "Current methods of nuclear isolation from liver disrupt the plasmalemmae via homogenization and separation of the nuclei by high centrifugal force (HCF) through gradients of sucrose or other substance... |
620 | Increased vessel density along with a reduction in fibrosis improves the efficacy of chemotherapy treatments. | [
{
"docid": "2565138",
"title": "Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer",
"text": "OBJECTIVE Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery. This study exa... | [
{
"docid": "9122283",
"title": "Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice.",
"text": "RATIONALE Multiple biological mechanisms contribute to the efficacy of cardiac cell therapy. Most prominent among these are dire... |
621 | Individuals with Alzheimers who participate in six months of physical activity improve cognitive function for up to 18 months. | [
{
"docid": "1642727",
"title": "Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial.",
"text": "CONTEXT Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized tr... | [
{
"docid": "5912283",
"title": "Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial.",
"text": "CONTEXT Insomnia is a common condition in older adults and is associated with a number of adverse medical, social, and psychologi... |
622 | Individuals with low serum vitamin D concentrations have decreased risk of multiple sclerosis. | [
{
"docid": "17000834",
"title": "Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study.",
"text": "OBJECTIVE To examine whether past high sun exposure is associated with a reduced risk of multiple sclerosis. \n DESIGN Population based case-control study. \n SETTING... | [
{
"docid": "25599283",
"title": "Low serum vitamin D is associated with high risk of diabetes in Korean adults.",
"text": "Vitamin D may play a role in glucose metabolism. A low vitamin D level has been associated with increased risk of diabetes mellitus, but the association has not been confirmed in As... |
624 | Induced hepatic stem cells possess the potential to differentiate into cholangiocytic cells. | [
{
"docid": "20033112",
"title": "Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors.",
"text": "Recent studies have demonstrated direct reprogramming of fibroblasts into a range of somatic cell types, but to date stem or progenitor cells have only been reprogrammed for the ... | [
{
"docid": "21676556",
"title": "Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity",
"text": "The midbody is a singular organelle formed between daughter cells during cytokinesis and required for their final separation. Midbodies persist in cells ... |
625 | Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells. | [
{
"docid": "20033112",
"title": "Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors.",
"text": "Recent studies have demonstrated direct reprogramming of fibroblasts into a range of somatic cell types, but to date stem or progenitor cells have only been reprogrammed for the ... | [
{
"docid": "3756384",
"title": "EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes.",
"text": "BACKGROUND & AIMS Hepatocytes in which the hepatitis B virus (HBV) is replicating exhibit loss of the chromatin modifying polycom... |
626 | Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria. | [
{
"docid": "16355392",
"title": "Modification of kidney barrier function by the urokinase receptor",
"text": "Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are... | [
{
"docid": "22241778",
"title": "Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus.",
"text": "The human kidneys filter 180 l of blood every day via about 2.5 million glomeruli. The three layers of the glomerular filtratio... |
631 | Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors. | [
{
"docid": "5468807",
"title": "ARID1A-mutated ovarian cancers depend on HDAC6 activity",
"text": "ARID1A, encoding a subunit of the SWI/SNF chromatin-remodelling complex, is the most frequently mutated epigenetic regulator across all human cancers. ARID1A and TP53 mutations are typically mutually exclu... | [
{
"docid": "9211173",
"title": "ARID1A mutations in endometriosis-associated ovarian carcinomas.",
"text": "BACKGROUND Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described. \n METHODS We sequenced ... |
632 | Inhibiting focal adhesion formation enables cells to convert mechanical strain into eventual scarring. | [
{
"docid": "5172048",
"title": "Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling",
"text": "Exuberant fibroproliferation is a common complication after injury for reasons that are not well understood. One key component of wound repair that is often overlooked is m... | [
{
"docid": "9507605",
"title": "Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCKindependent mechanism",
"text": "The transition of cell–matrix adhesions from the initial punctate focal complexes into the mature el... |
633 | Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis. | [
{
"docid": "5172048",
"title": "Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling",
"text": "Exuberant fibroproliferation is a common complication after injury for reasons that are not well understood. One key component of wound repair that is often overlooked is m... | [
{
"docid": "9507605",
"title": "Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCKindependent mechanism",
"text": "The transition of cell–matrix adhesions from the initial punctate focal complexes into the mature el... |
635 | Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling. | [
{
"docid": "1686997",
"title": "6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling",
"text": "The oxidative pentose phosphate pathway (PPP) contributes to tumour growth, but the precise contribution of 6-phosphogluconate dehydrogenase (6P... | [
{
"docid": "3761017",
"title": "Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion",
"text": "BACKGROUND Metformin, a widely used hypoglycemic drug, reduces stroke incidence and alleviates chronic inflammation in clinical trials. However, the effect of... |
638 | Input from mental and physical health care professionals is not effective at decreasing homelessness. | [
{
"docid": "25649714",
"title": "Mental health problems of homeless children and families: longitudinal study.",
"text": "OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. \n DESIGN Cross sectional, longitudinal study. \n SETTING City of Bir... | [
{
"docid": "73473433",
"title": "Mental health difficulties across childhood and mental health service use: findings from a longitudinal population-based study.",
"text": "BACKGROUND Over the past 20 years the prevalence of child and adolescent mental disorders in high-income countries has not changed d... |
640 | Inside the body, falciparum parasites reproduce asexually. | [
{
"docid": "6503185",
"title": "Malaria biology and disease pathogenesis: insights for new treatments",
"text": "Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan, claims the lives of nearly a million children each year in Africa alone and is a top public health concer... | [
{
"docid": "8373753",
"title": "Spatial and temporal heterogeneity of Anopheles mosquitoes and Plasmodium falciparum transmission along the Kenyan coast.",
"text": "The seasonal dynamics and spatial distributions of Anopheles mosquitoes and Plasmodium falciparum parasites were studied for one year at 30... |
642 | Insulin decreases risk of severe kidney failure. | [
{
"docid": "13619127",
"title": "Diabetes treatments and risk of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia: open cohort study in primary care",
"text": "OBJECTIVE To assess the risks of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia ... | [
{
"docid": "24921368",
"title": "Impaired awareness of hypoglycaemia: a review.",
"text": "Impaired awareness of hypoglycaemia (IAH) is an acquired complication of insulin therapy, which affects people with type 1 and insulin-treated type 2 diabetes mellitus, whereby the ability to perceive the onset of... |
643 | Insulin effects appetite via ventral tegmental neurons. | [
{
"docid": "15535511",
"title": "Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis.",
"text": "Dopaminergic midbrain neurons integrate signals on food palatability and food-associated reward into the complex control of energy homeostasis. To define the role of insu... | [
{
"docid": "32611468",
"title": "Ghrelin's second life: from appetite stimulator to glucose regulator.",
"text": "Ghrelin, a 28 amino acid peptide hormone produced by the stomach, was the first orexigenic hormone to be discovered from the periphery. The octanoyl modification at Ser³, mediated by ghrelin... |
645 | Intake of folic acid (FA) and vitamin B6 (VB6) increases levels of homocysteine. | [
{
"docid": "12810152",
"title": "Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.",
"text": "CONTEXT Hyperhomocysteinemia is caused by genetic and lifestyle influences, including low intakes of folate and vitamin B6. However, prospective data rel... | [
{
"docid": "33409100",
"title": "Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial.",
"text": "CONTEXT High plasma homocysteine levels are a risk factor for mortality and vascular disease in obs... |
646 | Intake of folic acid (FA) and vitamin B6 (VB6) reduces levels of homocysteine. | [
{
"docid": "12810152",
"title": "Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.",
"text": "CONTEXT Hyperhomocysteinemia is caused by genetic and lifestyle influences, including low intakes of folate and vitamin B6. However, prospective data rel... | [
{
"docid": "33409100",
"title": "Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial.",
"text": "CONTEXT High plasma homocysteine levels are a risk factor for mortality and vascular disease in obs... |
647 | Integrated care is ineffective at tackling multiple comorbidities. | [
{
"docid": "15041758",
"title": "Functional outcomes of multi-condition collaborative care and successful ageing: results of randomised trial",
"text": "OBJECTIVE To evaluate the effectiveness of integrated care for chronic physical diseases and depression in reducing disability and improving quality of... | [
{
"docid": "19945096",
"title": "Why do patients with multimorbidity in England report worse experiences in primary care? Evidence from the General Practice Patient Survey",
"text": "OBJECTIVES To describe and explain the primary care experiences of people with multiple long-term conditions in England. ... |
648 | Integrated care is successful at tackling multiple comorbidities. | [
{
"docid": "15041758",
"title": "Functional outcomes of multi-condition collaborative care and successful ageing: results of randomised trial",
"text": "OBJECTIVE To evaluate the effectiveness of integrated care for chronic physical diseases and depression in reducing disability and improving quality of... | [
{
"docid": "19945096",
"title": "Why do patients with multimorbidity in England report worse experiences in primary care? Evidence from the General Practice Patient Survey",
"text": "OBJECTIVES To describe and explain the primary care experiences of people with multiple long-term conditions in England. ... |
650 | Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance. | [
{
"docid": "12789595",
"title": "Computer assisted learning in undergraduate medical education.",
"text": "It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of on... | [
{
"docid": "24159217",
"title": "A mental health intervention for schoolchildren exposed to violence: a randomized controlled trial.",
"text": "CONTEXT No randomized controlled studies have been conducted to date on the effectiveness of psychological interventions for children with symptoms of posttraum... |
651 | Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons. | [
{
"docid": "9433958",
"title": "Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive stranded RNA viruses",
"text": "Although susceptibility of neurons in the brain to microbial infection is a major determinant of clinical outco... | [
{
"docid": "10559501",
"title": "Beta interferon controls West Nile virus infection and pathogenesis in mice.",
"text": "Studies with mice lacking the common plasma membrane receptor for type I interferon (IFN-αβR(-)(/)(-)) have revealed that IFN signaling restricts tropism, dissemination, and lethality... |
652 | Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons. | [
{
"docid": "9433958",
"title": "Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive stranded RNA viruses",
"text": "Although susceptibility of neurons in the brain to microbial infection is a major determinant of clinical outco... | [
{
"docid": "10559501",
"title": "Beta interferon controls West Nile virus infection and pathogenesis in mice.",
"text": "Studies with mice lacking the common plasma membrane receptor for type I interferon (IFN-αβR(-)(/)(-)) have revealed that IFN signaling restricts tropism, dissemination, and lethality... |
653 | Interleukin-18 plays an important role in the pathogenesis of atherosclerosis. | [
{
"docid": "24384587",
"title": "Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter",
"text": "Interleukin-18 (IL18) participates in atherogenesis through several putative mechanisms. Interruption of IL18 action reduces atherosclerosis in m... | [
{
"docid": "21372171",
"title": "Usefulness of high mobility group box 1 protein as a plasma biomarker in patient with peripheral artery disease.",
"text": "Atherosclerosis is often associated with chronic vascular inflammation. High-mobility group box 1 protein (HMGB1) plays various roles, not only as ... |
654 | Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi. | [
{
"docid": "57574395",
"title": "Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models",
"text": "Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercis... | [
{
"docid": "4407385",
"title": "A specific amyloid-β protein assembly in the brain impairs memory",
"text": "Memory function often declines with age, and is believed to deteriorate initially because of changes in synaptic function rather than loss of neurons. Some individuals then go on to develop Alzhe... |
655 | Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi. | [
{
"docid": "57574395",
"title": "Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models",
"text": "Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercis... | [
{
"docid": "4407385",
"title": "A specific amyloid-β protein assembly in the brain impairs memory",
"text": "Memory function often declines with age, and is believed to deteriorate initially because of changes in synaptic function rather than loss of neurons. Some individuals then go on to develop Alzhe... |
657 | Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation. | [
{
"docid": "8533245",
"title": "Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins.",
"text": "The ER-associated degradation (ERAD) pathway serves as an important cellular safeguard by directing incorrectly folded and unassembled proteins from the ER to the proteasome... | [
{
"docid": "37643601",
"title": "The flavivirus precursor membrane-envelope protein complex: structure and maturation.",
"text": "Many viruses go through a maturation step in the final stages of assembly before being transmitted to another host. The maturation process of flaviviruses is directed by the ... |
658 | It is not proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically. | [
{
"docid": "5293024",
"title": "Life is sweet: candy consumption and longevity.",
"text": "Our attitude towards candy—“if it tastes that good, it can't be healthy”—betrays society's puritanical stance towards pleasure. Candy has been blamed for various ills, including hyperactivity in children; however,... | [
{
"docid": "7454794",
"title": "Statins in the primary prevention of cardiovascular disease",
"text": "Statins are widely used in the evidence-based lowering of cardiovascular disease (CVD) risk. The use of these drugs for secondary prevention of CVD is well founded, but their expanding use in primary p... |
661 | JMJD6 catalyzes the hydroxylation of C-terminal lysine and supresses transcriptional activity. | [
{
"docid": "37204802",
"title": "JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation",
"text": "Jumonji domain-containing 6 (JMJD6) is a member of the Jumonji C domain-containing family of proteins. Compared to other members of the family, the cellular activity of JMJ... | [
{
"docid": "25606339",
"title": "Toll-like receptor-3 mediates HIV-1 transactivation via NFκB and JNK pathways and histone acetylation, but prolonged activation suppresses Tat and HIV-1 replication.",
"text": "TLR3 has been implicated in the pathogenesis of several viral infections, including SIV- and H... |
662 | JMJD6 slows the hydroxylation of C-terminal lysine | [
{
"docid": "37204802",
"title": "JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation",
"text": "Jumonji domain-containing 6 (JMJD6) is a member of the Jumonji C domain-containing family of proteins. Compared to other members of the family, the cellular activity of JMJ... | [
{
"docid": "29788648",
"title": "NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5.",
"text": "NuA4, the major H4 lysine acetyltransferase (KAT) complex in Saccharomyces cerevisiae, is recruited to promoters and stimulates transcription in... |
663 | KLF4 is necessary for VSMCs to gain genetic characteristics of other cell types within atherosclerotic lesions. | [
{
"docid": "22080671",
"title": "KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis",
"text": "Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controv... | [
{
"docid": "15879931",
"title": "Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses",
"text": "Inflammation and macrophage foam cells are characteristic features of atherosclerotic lesions, but the mechanisms linking cholesterol accumulation to inflam... |
665 | KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia. | [
{
"docid": "12580014",
"title": "Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes",
"text": "Expression of the intermediate filament protein keratin 17 (K17) is robustly upregulated in inflammatory skin diseases and in many tumors originating in stratified and pseudos... | [
{
"docid": "13989491",
"title": "Acids: Structures, Properties, and Functions (University Science Books, Sausalito, CA, 2000).",
"text": "Humans expressing a defective form of the transcription factor AIRE (autoimmune regulator) develop multiorgan autoimmune disease. We used aire- deficient mice to test... |
666 | Kir7.1 modulates channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus. | [
{
"docid": "4469125",
"title": "G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons",
"text": "The regulated release of anorexigenic α-melanocyte stimulating hormone (α-MSH) and orexigenic Agouti-related protein (AgRP) from discrete hypothalamic arcuate neurons onto common target si... | [
{
"docid": "1070920",
"title": "A neural basis for melanocortin-4 receptor regulated appetite",
"text": "Pro-opiomelanocortin (POMC)- and agouti-related peptide (AgRP)-expressing neurons of the arcuate nucleus of the hypothalamus (ARC) are oppositely regulated by caloric depletion and coordinately stimu... |
667 | Klf2 is important for proper myeloid cell function. | [
{
"docid": "6493422",
"title": "The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.",
"text": "Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control t... | [
{
"docid": "14407673",
"title": "Myeloid-specific Krüppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis.",
"text": "RATIONALE Hemizygous deficiency of the transcription factor Krüppel-like factor 2 (KLF2) has been shown previously to augment atheros... |
668 | Klf4 is important for proper myeloid cell differentiation. | [
{
"docid": "6493422",
"title": "The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.",
"text": "Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control t... | [
{
"docid": "18489989",
"title": "Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4.",
"text": "Embryonic stem (ES) cells homozygous for a Shp-2 mutation (Shp-2(Delta46-110)) demonstrate leukemia inhibitory factor (LIF) hypersensit... |
669 | Klf4 is not required for proper myeloid cell differentiation. | [
{
"docid": "6493422",
"title": "The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.",
"text": "Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control t... | [
{
"docid": "22150633",
"title": "A core Klf circuitry regulates self-renewal of embryonic stem cells",
"text": "Embryonic stem (ES) cells are unique in their ability to self-renew indefinitely and maintain pluripotency. These properties require transcription factors that specify the gene expression prog... |
670 | Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes epithelial damage. | [
{
"docid": "5573975",
"title": "Activin–like kinase–3 activity is important for kidney regeneration and reversal of fibrosis",
"text": "Molecules associated with the transforming growth factor β (TGF-β) superfamily, such as bone morphogenic proteins (BMPs) and TGF-β, are key regulators of inflammation, ... | [
{
"docid": "25928548",
"title": "BMP receptor ALK3 controls collecting system development.",
"text": "The molecular signals that regulate growth and branching of the ureteric bud during formation of the renal collecting system are largely undefined. Members of the bone morphogenetic protein (BMP) family... |
671 | Knockout proximal tubule-specific deletion of the BMP receptor Alk3 causes fibrosis. | [
{
"docid": "5573975",
"title": "Activin–like kinase–3 activity is important for kidney regeneration and reversal of fibrosis",
"text": "Molecules associated with the transforming growth factor β (TGF-β) superfamily, such as bone morphogenic proteins (BMPs) and TGF-β, are key regulators of inflammation, ... | [
{
"docid": "25928548",
"title": "BMP receptor ALK3 controls collecting system development.",
"text": "The molecular signals that regulate growth and branching of the ureteric bud during formation of the renal collecting system are largely undefined. Members of the bone morphogenetic protein (BMP) family... |
672 | L3MBTL2 binds to H2AK119Ub marked chromatin to form a PRC1 complex. | [
{
"docid": "15635366",
"title": "The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.",
"text": "L3mbtl2 has been implicated in transcriptional repression and chromatin compaction but its biological function has n... | [
{
"docid": "1791637",
"title": "Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains",
"text": "In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone mo... |
673 | LDL cholesterol has a causal role in the development of cardiovascular disease. | [
{
"docid": "2095573",
"title": "LDL-cholesterol concentrations: a genome-wide association study",
"text": "BACKGROUND LDL cholesterol has a causal role in the development of cardiovascular disease. Improved understanding of the biological mechanisms that underlie the metabolism and regulation of LDL cho... | [
{
"docid": "30981192",
"title": "How to control residual cardiovascular risk despite statin treatment: focusing on HDL-cholesterol.",
"text": "Lowering low-density lipoprotein-cholesterol (LDL-C) is the primary target in the management of dyslipidemia in patients at high risk of cardiovascular disease. ... |
676 | LRBA prevents CTLA - 4 recycling. | [
{
"docid": "857189",
"title": "Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations",
"text": "The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity in mice. We studied a large famil... | [
{
"docid": "13398997",
"title": "High CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 coinhibition and resistance to belatacept.",
"text": "The CD28/cytotoxic T-lymphocyte antigen 4 (CTLA-4)blocker belatacept selectively inhibits alloreactive T cell responses but is associated... |
677 | LRBA promotes CTLA - 4 recycling. | [
{
"docid": "857189",
"title": "Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations",
"text": "The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity in mice. We studied a large famil... | [
{
"docid": "13398997",
"title": "High CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 coinhibition and resistance to belatacept.",
"text": "The CD28/cytotoxic T-lymphocyte antigen 4 (CTLA-4)blocker belatacept selectively inhibits alloreactive T cell responses but is associated... |
679 | LSD1-positive promoters are associated with RNA polymerase II | [
{
"docid": "13639330",
"title": "Histone Methylation-Dependent Mechanisms Impose Ligand Dependency for Gene Activation by Nuclear Receptors",
"text": "Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actual ... | [
{
"docid": "23269537",
"title": "Cyclin D1 activation in B-cell malignancy: association with changes in histone acetylation, DNA methylation, and RNA polymerase II binding to both promoter and distal sequences.",
"text": "Cyclin D1 expression is deregulated by chromosome translocation in mantle cell lym... |
680 | Lack of FGF21 in mice increases life expectancy. | [
{
"docid": "9315213",
"title": "Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice",
"text": "BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glu... | [
{
"docid": "6227220",
"title": "Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine",
"text": "Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal ... |
681 | Lack of FGF21 in mice leads to atherosclerotic plaque formation. | [
{
"docid": "9315213",
"title": "Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice",
"text": "BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glu... | [
{
"docid": "970012",
"title": "Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis",
"text": "Molecular mechanisms underlying the cold-associated high cardiovascular risk remain unknown. Here, we show that the cold-triggered food-intake-independent lipolysis... |
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