query_id stringlengths 1 4 | query stringlengths 26 249 | positive_passages listlengths 1 5 | negative_passages listlengths 16 20 |
|---|---|---|---|
871 | Obesity decreases life quality. | [
{
"docid": "195689316",
"title": "Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies.",
"text": "BACKGROUND The main associations of body-mass index (BMI) with overall and cause-specific mortality can best be assessed by long-term prospective... | [
{
"docid": "43220289",
"title": "Psychological Outcome 4 Years after Restrictive Bariatric Surgery",
"text": "Extreme obesity is associated with severe psychiatric and somatic comorbidity and impairment of psychosocial functioning. Bariatric surgery is the most effective treatment not only with regard t... |
876 | Obesity raises life quality. | [
{
"docid": "195689316",
"title": "Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies.",
"text": "BACKGROUND The main associations of body-mass index (BMI) with overall and cause-specific mortality can best be assessed by long-term prospective... | [
{
"docid": "43220289",
"title": "Psychological Outcome 4 Years after Restrictive Bariatric Surgery",
"text": "Extreme obesity is associated with severe psychiatric and somatic comorbidity and impairment of psychosocial functioning. Bariatric surgery is the most effective treatment not only with regard t... |
877 | Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain. | [
{
"docid": "313394",
"title": "A Functional Neuroimaging Study of Sound Localization: Visual Cortex Activity Predicts Performance in Early-Blind Individuals",
"text": "Blind individuals often demonstrate enhanced nonvisual perceptual abilities. However, the neural substrate that underlies this improved ... | [
{
"docid": "3095620",
"title": "Distinct Parietal and Temporal Pathways to the Homologues of Broca's Area in the Monkey",
"text": "The homologues of the two distinct architectonic areas 44 and 45 that constitute the anterior language zone (Broca's region) in the human ventrolateral frontal lobe were rec... |
881 | Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans. | [
{
"docid": "14803797",
"title": "Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis",
"text": "Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trime... | [
{
"docid": "6327940",
"title": "Vegan proteins may reduce risk of cancer, obesity, and cardiovascular disease by promoting increased glucagon activity.",
"text": "Amino acids modulate the secretion of both insulin and glucagon; the composition of dietary protein therefore has the potential to influence ... |
883 | Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans. | [
{
"docid": "14803797",
"title": "Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis",
"text": "Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trime... | [
{
"docid": "6327940",
"title": "Vegan proteins may reduce risk of cancer, obesity, and cardiovascular disease by promoting increased glucagon activity.",
"text": "Amino acids modulate the secretion of both insulin and glucagon; the composition of dietary protein therefore has the potential to influence ... |
884 | Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians. | [
{
"docid": "14803797",
"title": "Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis",
"text": "Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trime... | [
{
"docid": "33684572",
"title": "Transmission of atherosclerosis susceptibility with gut microbial transplantation.",
"text": "Recent studies indicate both clinical and mechanistic links between atherosclerotic heart disease and intestinal microbial metabolism of certain dietary nutrients producing trim... |
885 | One in five surgical randomized controlled trials are discontinued early. | [
{
"docid": "6477536",
"title": "Discontinuation and non-publication of surgical randomised controlled trials: observational study",
"text": "OBJECTIVE To determine the rate of early discontinuation and non-publication of randomised controlled trials involving patients undergoing surgery. \n DESIGN Cro... | [
{
"docid": "9967265",
"title": "Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants.",
"text": "BACKGROUND Patent ductus arteriosus (PDA) with significant left to right shunt in preterm infants increases morbidity and mortality. Ea... |
886 | One in two surgical randomized controlled trials are discontinued early. | [
{
"docid": "6477536",
"title": "Discontinuation and non-publication of surgical randomised controlled trials: observational study",
"text": "OBJECTIVE To determine the rate of early discontinuation and non-publication of randomised controlled trials involving patients undergoing surgery. \n DESIGN Cro... | [
{
"docid": "9967265",
"title": "Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants.",
"text": "BACKGROUND Patent ductus arteriosus (PDA) with significant left to right shunt in preterm infants increases morbidity and mortality. Ea... |
890 | Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments. | [
{
"docid": "2097256",
"title": "Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis",
"text": "BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and ... | [
{
"docid": "18816720",
"title": "Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages",
"text": "BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors ... |
891 | Origin gross domestic product(GDP) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments. | [
{
"docid": "2097256",
"title": "Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis",
"text": "BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and ... | [
{
"docid": "18816720",
"title": "Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages",
"text": "BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors ... |
893 | Osteocytes have an essential role in G-CSF induced HSPC mobilization. | [
{
"docid": "13509809",
"title": "Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells.",
"text": "The bone marrow (BM) niche comprises multiple cell types that regulate hematopoietic stem/progenitor cell (HSPC) migration out of the niche and into the circulation. Here,... | [
{
"docid": "38899659",
"title": "PTH Signaling in Osteoprogenitors Is Essential for B-Lymphocyte Differentiation and Mobilization.",
"text": "Cells of the osteoblast lineage provide critical support for B lymphopoiesis in the bone marrow (BM). Parathyroid hormone (PTH) signaling in osteoblastic cells th... |
894 | Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia. | [
{
"docid": "14724693",
"title": "Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial.",
"text": "CONTEXT Chronic low back pain (LBP) with degenerative lumbar osteoarthritis (OA) is widespread in the... | [
{
"docid": "37562370",
"title": "Cellular and histopathological changes in the infrapatellar fat pad in the monoiodoacetate model of osteoarthritis pain.",
"text": "OBJECTIVE The infrapatellar fat pad (IPFP) has been identified as a source of anterior knee pain. Fibrosis and marked inflammatory infiltra... |
895 | Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L. | [
{
"docid": "18750453",
"title": "Assessment of Volume Depletion in Children with Malaria",
"text": "Background The degree of volume depletion in severe malaria is currently unknown, although knowledge of fluid compartment volumes can guide therapy. To assist management of severely ill children, and to t... | [
{
"docid": "9254550",
"title": "Age as a risk factor for thrombocytopenia and anaemia in children treated for acute uncomplicated falciparum malaria.",
"text": "BACKGROUND & OBJECTIVES Anaemia is commonly observed in children with malaria, but reports on leucocyte and platelet count abnormalities associ... |
896 | Overexpressing Cnp1 N-tail variants exacerbates the temperature-sensitive growth defect of scm3-139. | [
{
"docid": "14338915",
"title": "Fission Yeast Scm3: A CENP-A Receptor Required for Integrity of Subkinetochore Chromatin",
"text": "The mechanisms ensuring specific incorporation of CENP-A at centromeres are poorly understood. Mis16 and Mis18 are required for CENP-A localization at centromeres and form... | [
{
"docid": "10189634",
"title": "Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly",
"text": "CENP-A chromatin forms the foundation for kinetochore assembly. Replication-independent incorporation of CENP-A at centromeres depends on its chaperone HJURP(Scm3), and Mis18 in verte... |
897 | Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139. | [
{
"docid": "14338915",
"title": "Fission Yeast Scm3: A CENP-A Receptor Required for Integrity of Subkinetochore Chromatin",
"text": "The mechanisms ensuring specific incorporation of CENP-A at centromeres are poorly understood. Mis16 and Mis18 are required for CENP-A localization at centromeres and form... | [
{
"docid": "10189634",
"title": "Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly",
"text": "CENP-A chromatin forms the foundation for kinetochore assembly. Replication-independent incorporation of CENP-A at centromeres depends on its chaperone HJURP(Scm3), and Mis18 in verte... |
898 | Oxidative DNA damage activates STING signalling. | [
{
"docid": "13106686",
"title": "Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.",
"text": "Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE... | [
{
"docid": "1049501",
"title": "Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease",
"text": "Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are generated and their roles in sterile inflammatio... |
899 | Oxidative DNA damage inhibits STING signalling. | [
{
"docid": "13106686",
"title": "Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.",
"text": "Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE... | [
{
"docid": "1049501",
"title": "Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease",
"text": "Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are generated and their roles in sterile inflammatio... |
900 | Oxidative phosphorylation is one of the primary glycometabolic pathways in cells. | [
{
"docid": "18678095",
"title": "Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport",
"text": "Fast axonal transport (FAT) requires consistent energy over long distances to fuel the molecular motors that transport vesicles. We demonstrate that glycolysis provides ATP for the FAT of ... | [
{
"docid": "14496749",
"title": "A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span",
"text": "Oxidative stress influences cell survival and homeostasis, but the mechanisms underlying the biological effects of oxidative stress remain to be elucidated. Here, ... |
901 | PCSK9 inhibitors decrease plasma Lp(a) levels. | [
{
"docid": "6540064",
"title": "Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans",
"text": "BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipopro... | [
{
"docid": "33118292",
"title": "Optimal therapy for reduction of lipoprotein(a).",
"text": "WHAT IS KNOWN AND OBJECTIVE There is a growing body of experimental and clinical evidence for the atherogenic and pro-thrombotic potential of Lipoprotein(a) [Lp(a)], as well as for its causative role in coronary... |
902 | PD-1 triggering on monocytes enhances IL-10 production by monocytes. | [
{
"docid": "10648422",
"title": "Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection",
"text": "Viral replication and microbial translocation from the gut to the blood during HIV infection lead to hyperimmune activation, which contributes... | [
{
"docid": "5752492",
"title": "Characterization of Programmed Death-1 Homologue-1 (PD-1H) Expression and Function in Normal and HIV Infected Individuals",
"text": "Chronic immune activation that persists despite anti-retroviral therapy (ART) is the strongest predictor of disease progression in HIV infe... |
908 | PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes. | [
{
"docid": "6923961",
"title": "Prostaglandin E2 promotes intestinal tumor growth via DNA methylation",
"text": "Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms u... | [
{
"docid": "11915280",
"title": "Suppression of intestinal neoplasia by deletion of Dnmt3b",
"text": "Aberrant gene silencing accompanied by DNA methylation is associated with neoplastic progression in many tumors that also show global loss of DNA methylation. Using conditional inactivation of de novo m... |
909 | PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice. | [
{
"docid": "11254556",
"title": "Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity",
"text": "Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the peripher... | [
{
"docid": "10666475",
"title": "The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase",
"text": "Neuropathic pain is a major, intractable clinical problem and its pathophysiology is not well understood. Although recent gene expression profil... |
910 | PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice. | [
{
"docid": "11254556",
"title": "Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity",
"text": "Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the peripher... | [
{
"docid": "25141908",
"title": "Expression of a human cytomegalovirus latency-associated homolog of interleukin-10 during the productive phase of infection.",
"text": "The human cytomegalovirus UL111A region is active during both productive and latent phases of infection. During productive infection, t... |
912 | PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice. | [
{
"docid": "11254556",
"title": "Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity",
"text": "Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the peripher... | [
{
"docid": "14188138",
"title": "Abnormal Spine Morphology and Enhanced LTP in LIMK-1 Knockout Mice",
"text": "In vitro studies indicate a role for the LIM kinase family in the regulation of cofilin phosphorylation and actin dynamics. In addition, abnormal expression of LIMK-1 is associated with William... |
916 | PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients. | [
{
"docid": "18037805",
"title": "Polycomb Proteins Remain Bound to Chromatin and DNA during DNA Replication In Vitro",
"text": "The transcriptional status of a gene can be maintained through multiple rounds of cell division during development. This epigenetic effect is believed to reflect heritable chan... | [
{
"docid": "463309",
"title": "Transformation of intact yeast cells treated with alkali cations.",
"text": "Intact yeast cells treated with alkali cations took up plasmid DNA. Li+, Cs+, Rb+, K+, and Na+ were effective in inducing competence. Conditions for the transformation of Saccharomyces cerevisiae ... |
917 | PTEN is a regulator for the transcriptional activity of SRF | [
{
"docid": "34071621",
"title": "Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation",
"text": "Vascular disease progression is associated with marked changes in vascular smooth muscle cell (SMC) phenotype and function. SMC contractile... | [
{
"docid": "15176526",
"title": "Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions",
"text": "Epidermal homeostasis depends on a balance between stem cell renewal and differentiation and is regulated by extrinsic signals from... |
919 | Participants who quit smoking reduce lung cancer risk by approximately 50%. | [
{
"docid": "16422880",
"title": "Effect of smoking reduction on lung cancer risk.",
"text": "CONTEXT Many smokers are unable or unwilling to completely quit smoking. A proposed means of harm reduction is to reduce the number of cigarettes smoked per day. However, it is not clear whether this strategy de... | [
{
"docid": "26067999",
"title": "Screening for Lung Cancer: U.S. Preventive Services Task Force Recommendation Statement",
"text": "The U.S. Preventive Services Task Force (USPSTF) makes recommendations about the effectiveness of specific preventive care services for patients without related signs or sy... |
923 | Patients in stable partnerships have a slower progression from HIV to AIDS. | [
{
"docid": "17077004",
"title": "Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study.",
"text": "OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patient... | [
{
"docid": "23304931",
"title": "Immunophenotypic analysis of AIDS-related diffuse large B-cell lymphoma and clinical implications in patients from AIDS malignancies consortium clinical trials 010 and 034",
"text": "PURPOSE Diffuse large B-cell lymphoma (DLBCL) represents a clinically heterogeneous dise... |
925 | Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships. | [
{
"docid": "17077004",
"title": "Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study.",
"text": "OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patient... | [
{
"docid": "36202354",
"title": "Pharmaceutical Public-Private Partnerships in the United States and Europe: Moving from the Bench to the Bedside",
"text": "Both to address unmet medical needs and to improve industry competitiveness, regulators in both the United States and the European Union have taken... |
926 | Patients with common epithelial cancers are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas. | [
{
"docid": "16390264",
"title": "Social variations in access to hospital care for patients with colorectal, breast, and lung cancer between 1999 and 2006: retrospective analysis of hospital episode statistics",
"text": "OBJECTIVES To determine the extent to which type of hospital admission (emergency co... | [
{
"docid": "5641851",
"title": "Social and geographical factors affecting access to treatment of colorectal cancer: a cancer registry study",
"text": "OBJECTIVE Cancer outcomes vary between and within countries with patients from deprived backgrounds known to have inferior survival. The authors set out ... |
927 | Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas. | [
{
"docid": "16390264",
"title": "Social variations in access to hospital care for patients with colorectal, breast, and lung cancer between 1999 and 2006: retrospective analysis of hospital episode statistics",
"text": "OBJECTIVES To determine the extent to which type of hospital admission (emergency co... | [
{
"docid": "5641851",
"title": "Social and geographical factors affecting access to treatment of colorectal cancer: a cancer registry study",
"text": "OBJECTIVE Cancer outcomes vary between and within countries with patients from deprived backgrounds known to have inferior survival. The authors set out ... |
928 | Patients with microcytosis and higher erythrocyte count are more vulnerable to severe malarial anaemia when infected with Plasmodium falciparum. | [
{
"docid": "18174210",
"title": "Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia",
"text": "BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part o... | [
{
"docid": "2460304",
"title": "Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance.",
"text": "Erythrocytes carrying a variant hemoglobin allele (HbS), which causes sickle cell disease and resists infection by... |
929 | Patients with microcytosis and higher erythrocyte count were more resistant to severe malarial anaemia when infected with Plasmodium falciparum. | [
{
"docid": "18174210",
"title": "Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia",
"text": "BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part o... | [
{
"docid": "2460304",
"title": "Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance.",
"text": "Erythrocytes carrying a variant hemoglobin allele (HbS), which causes sickle cell disease and resists infection by... |
930 | Patients with panic anxiety show decreased CSF levels of hypocretin. | [
{
"docid": "16056514",
"title": "A KEY ROLE FOR OREXIN IN PANIC ANXIETY",
"text": "Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central gamma-aminobutyric acid (GABA) activity as well as marked i... | [
{
"docid": "44830890",
"title": "Comorbidity of depressive and anxiety disorders in chronic daily headache and its subtypes.",
"text": "OBJECTIVE To investigate the frequency of depressive and anxiety disorders in patients with chronic daily headache. \n BACKGROUND There is a lack of data in the liter... |
933 | Pediatric SCD patients with vaso-occlusive crisis show increased morphine use after breathing 80 ppm iNO for 4 hours. | [
{
"docid": "14711483",
"title": "Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease.",
"text": "CONTEXT Vaso-occlusion is central to the painful crises and acute and chronic organ damage in sickle cell disease. Abnormal nitric ox... | [
{
"docid": "29947146",
"title": "Intestinal methane production in obese individuals is associated with a higher body mass index.",
"text": "BACKGROUND Obesity is an epidemic that affects 1 in 3 individuals in the United States, and recent evidence suggests that enteric microbiota may play a significant ... |
934 | Perigenital skin is not the primary site of HIV acquisition. | [
{
"docid": "8563659",
"title": "Persistence of HIV-1 Receptor-Positive Cells after HSV-2 Reactivation: A Potential Mechanism for Increased HIV-1 Acquisition",
"text": "To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition, we conducted in situ analysis ... | [
{
"docid": "28821565",
"title": "Concentrations of tenofovir and emtricitabine in saliva: implications for preexposure prophylaxis of oral HIV acquisition.",
"text": "To prevent acquisition of HIV through oral sex, drugs used for preexposure prophylaxis (Prep) need to diffuse in saliva. We measured teno... |
935 | Peroxynitrite is required for induction of T cell tolerance. | [
{
"docid": "5483793",
"title": "Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer",
"text": "Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we show here that ... | [
{
"docid": "42693833",
"title": "Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis.",
"text": "Foxp3(+) T cells play a critical role for the maintenance of immune tolerance. Here we show that in mice, Foxp3(+) T ce... |
938 | Persister cells provide relapse resistance in cancer patients. | [
{
"docid": "26231129",
"title": "A framework for understanding and targeting residual disease in oncogene-driven solid cancers",
"text": "Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer. However, complete and durable responses to targeted therapy are... | [
{
"docid": "25895285",
"title": "Quantitative phosphoproteomic analysis of acquired cancer drug resistance to pazopanib and dasatinib",
"text": "Acquired drug resistance impacts the majority of patients being treated with tyrosine kinase inhibitors (TKIs) and remains a key challenge in modern anti-cance... |
939 | Persistor cells are one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients. | [
{
"docid": "26231129",
"title": "A framework for understanding and targeting residual disease in oncogene-driven solid cancers",
"text": "Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer. However, complete and durable responses to targeted therapy are... | [
{
"docid": "9929089",
"title": "Subsequent chemotherapy reverses acquired tyrosine kinase inhibitor resistance and restores response to tyrosine kinase inhibitor in advanced non-small-cell lung cancer",
"text": "BACKGROUND Patients with advanced or metastatic non-small cell lung cancer (NSCLC) can devel... |
940 | Pharmacist attendance at ward rounds increases adverse events in wards. | [
{
"docid": "12258338",
"title": "Pharmacist participation on physician rounds and adverse drug events in the intensive care unit.",
"text": "CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug cost... | [
{
"docid": "21260231",
"title": "Validity and reliability of observational methods for studying medication administration errors.",
"text": "The validity and reliability of observational methods for studying medication administration errors (MAEs) were studied. Between January and June 1998, two pharmac... |
941 | Pharmacist attendance at ward rounds reduces adverse events in wards. | [
{
"docid": "12258338",
"title": "Pharmacist participation on physician rounds and adverse drug events in the intensive care unit.",
"text": "CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug cost... | [
{
"docid": "21260231",
"title": "Validity and reliability of observational methods for studying medication administration errors.",
"text": "The validity and reliability of observational methods for studying medication administration errors (MAEs) were studied. Between January and June 1998, two pharmac... |
942 | Phase information is useful for predicting donor-recipient matches in organ transplantation. | [
{
"docid": "11527199",
"title": "MHC Haplotype Matching for Unrelated Hematopoietic Cell Transplantation",
"text": "Background Current criteria for the selection of unrelated donors for hematopoietic cell transplantation (HCT) include matching for the alleles of each human leukocyte antigen (HLA) locus... | [
{
"docid": "16737210",
"title": "Kidney paired donation and optimizing the use of live donor organs.",
"text": "CONTEXT Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant. Kidney paired donation (KPD) offers incompa... |
944 | Physical activity does not improve cognitive function in individuals with Alzheimers. | [
{
"docid": "1642727",
"title": "Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial.",
"text": "CONTEXT Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized tr... | [
{
"docid": "45336190",
"title": "Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease.",
"text": "OBJECTIVE To evaluate the safety, tolerability, and amyloid beta (Abeta) response to the gamma-secretase inhibitor LY450139 in Alzheimer disease. \n... |
945 | Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth. | [
{
"docid": "8428935",
"title": "Relationship of physical activity and television watching with body weight and level of fatness among children: results from the Third National Health and Nutrition Examination Survey.",
"text": "CONTEXT Physical inactivity contributes to weight gain in adults, but whethe... | [
{
"docid": "18537148",
"title": "Comparison of Maximal Oxygen Consumption Between Black and White Prepubertal and Pubertal Children",
"text": "The purpose of this investigation was to determine whether maximal oxygen consumption (VO2max) differed between two selected groups of black and white children a... |
946 | Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth. | [
{
"docid": "8428935",
"title": "Relationship of physical activity and television watching with body weight and level of fatness among children: results from the Third National Health and Nutrition Examination Survey.",
"text": "CONTEXT Physical inactivity contributes to weight gain in adults, but whethe... | [
{
"docid": "18537148",
"title": "Comparison of Maximal Oxygen Consumption Between Black and White Prepubertal and Pubertal Children",
"text": "The purpose of this investigation was to determine whether maximal oxygen consumption (VO2max) differed between two selected groups of black and white children a... |
949 | Physical injury represses transgultaminase activity. | [
{
"docid": "13578199",
"title": "Transglutaminase 2 Undergoes a Large Conformational Change upon Activation ",
"text": "Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues an... | [
{
"docid": "16905344",
"title": "Another Barrier to Regeneration in the CNS: Activated Macrophages Induce Extensive Retraction of Dystrophic Axons through Direct Physical Interactions",
"text": "Injured axons of the adult CNS undergo lengthy retraction from the initial site of axotomy after spinal cord ... |
951 | Piezo1 channels are sensors for cell migration in epithelial cells. | [
{
"docid": "21414718",
"title": "Piezo1 Is as a Novel Trefoil Factor Family 1 Binding Protein that Promotes Gastric Cancer Cell Mobility In Vitro",
"text": "Trefoil factor family 1 (TFF1) is a member of the TFF-domain peptide family involved in epithelial restitution and cell motility. Recently, we scre... | [
{
"docid": "4422723",
"title": "Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia",
"text": "For an epithelium to provide a protective barrier, it must maintain homeostatic cell numbers by matching the number of dividing cells with the number of dying cells. Although... |
952 | Pioglitazone use is not associated with an increased risk of prostate cancer. | [
{
"docid": "3355397",
"title": "Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes.",
"text": "IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. \n OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of b... | [
{
"docid": "31229233",
"title": "Use of thiazolidinediones and the risk of bladder cancer among people with type 2 diabetes: a meta-analysis.",
"text": "BACKGROUND Patients with type 2 diabetes have a 40% increased risk of bladder cancer. Thiazolidinediones, especially pioglitazone, may increase the ris... |
953 | Pioglitazone use is significantly associated with an increased risk of pancreatic cancer. | [
{
"docid": "3355397",
"title": "Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes.",
"text": "IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. \n OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of b... | [
{
"docid": "31229233",
"title": "Use of thiazolidinediones and the risk of bladder cancer among people with type 2 diabetes: a meta-analysis.",
"text": "BACKGROUND Patients with type 2 diabetes have a 40% increased risk of bladder cancer. Thiazolidinediones, especially pioglitazone, may increase the ris... |
954 | Pioglitazone use is significantly associated with an increased risk of prostate cancer. | [
{
"docid": "3355397",
"title": "Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes.",
"text": "IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. \n OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of b... | [
{
"docid": "31229233",
"title": "Use of thiazolidinediones and the risk of bladder cancer among people with type 2 diabetes: a meta-analysis.",
"text": "BACKGROUND Patients with type 2 diabetes have a 40% increased risk of bladder cancer. Thiazolidinediones, especially pioglitazone, may increase the ris... |
955 | Pioneer factor OCT3/4 interacts with major chromatin remodeling factors. | [
{
"docid": "2078658",
"title": "Oct4 links multiple epigenetic pathways to the pluripotency network",
"text": "Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-renewal, pluripotency, and somatic cell reprogramming. However, limited information is available on Oct4... | [
{
"docid": "4896726",
"title": "Pioneer factor Pax7 deploys a stable enhancer repertoire for specification of cell fate",
"text": "Pioneer transcription factors establish new cell-fate competence by triggering chromatin remodeling. However, many features of pioneer action, such as their kinetics and sta... |
959 | Polymeal nutrition increases cardiovascular mortality. | [
{
"docid": "8780599",
"title": "The Polymeal: a more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%.",
"text": "OBJECTIVE Although the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk manage... | [
{
"docid": "75636923",
"title": "Prevalence of the Metabolic Syndrome Among Us Adults: Findings From the Third National Health and Nutrition Examination Survey",
"text": "Metabolic syndrome is diagnosed when three or more of the following criteria are met: abdominal obesity (waist circumference more tha... |
962 | Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules. | [
{
"docid": "13931771",
"title": "GRSF1 Regulates RNA Processing in Mitochondrial RNA Granules",
"text": "Various specialized domains have been described in the cytosol and the nucleus; however, little is known about compartmentalization within the mitochondrial matrix. GRSF1 (G-rich sequence factor 1) i... | [
{
"docid": "20018321",
"title": "Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis.",
"text": "Cytoplasmic RNA granules play a central role in mRNA metabolism, but the importance of mitochondrial RNA granules remains relatively unexplored. We character... |
963 | Pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates. | [
{
"docid": "4162857",
"title": "Linking Splicing to Pol II Transcription Stabilizes Pre-mRNAs and Influences Splicing Patterns",
"text": "RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in v... | [
{
"docid": "21330280",
"title": "The Spliceosome: Design Principles of a Dynamic RNP Machine",
"text": "Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its regulation. Whereas most RNP enzymes are stable in composition and harbor preformed active sites, the spliceoso... |
964 | Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates. | [
{
"docid": "4162857",
"title": "Linking Splicing to Pol II Transcription Stabilizes Pre-mRNAs and Influences Splicing Patterns",
"text": "RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in v... | [
{
"docid": "21330280",
"title": "The Spliceosome: Design Principles of a Dynamic RNP Machine",
"text": "Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its regulation. Whereas most RNP enzymes are stable in composition and harbor preformed active sites, the spliceoso... |
965 | Prescribed exercise training improves quality of life. | [
{
"docid": "40817021",
"title": "Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial.",
"text": "CONTEXT Findings from previous studies of the effects of exercise training on patient-reported health status have been inconsistent. ... | [
{
"docid": "2820454",
"title": "Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension.",
"text": "BACKGROUND Pulmonary hypertension (PH) is associated with restricted physical capacity, limited quality of life, and a poor p... |
969 | PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication. | [
{
"docid": "19356271",
"title": "hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity.",
"text": "Prim-pol is a recently identified DNA primase-polymerase belonging to the archaeao-eukaryotic primase (AEP) superfamily. Here, we characterize a previously un... | [
{
"docid": "28904104",
"title": "Repriming of DNA synthesis at stalled replication forks by human PrimPol",
"text": "DNA replication forks that collapse during the process of genomic duplication lead to double-strand breaks and constitute a threat to genomic stability. The risk of fork collapse is highe... |
970 | PrimPol generates short DNA replication intermediates on the leading strand during DNA replication. | [
{
"docid": "19356271",
"title": "hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity.",
"text": "Prim-pol is a recently identified DNA primase-polymerase belonging to the archaeao-eukaryotic primase (AEP) superfamily. Here, we characterize a previously un... | [
{
"docid": "28904104",
"title": "Repriming of DNA synthesis at stalled replication forks by human PrimPol",
"text": "DNA replication forks that collapse during the process of genomic duplication lead to double-strand breaks and constitute a threat to genomic stability. The risk of fork collapse is highe... |
972 | Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2. | [
{
"docid": "46695481",
"title": "Human papillomavirus and Papanicolaou tests to screen for cervical cancer.",
"text": "BACKGROUND Screening for cervical cancer based on testing for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neo... | [
{
"docid": "27446873",
"title": "Rate of cervical cancer, severe intraepithelial neoplasia, and adenocarcinoma in situ in primary HPV DNA screening with cytology triage: randomised study within organised screening programme.",
"text": "OBJECTIVE To assess the performance and impact of primary human papi... |
973 | Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology. | [
{
"docid": "27446873",
"title": "Rate of cervical cancer, severe intraepithelial neoplasia, and adenocarcinoma in situ in primary HPV DNA screening with cytology triage: randomised study within organised screening programme.",
"text": "OBJECTIVE To assess the performance and impact of primary human papi... | [
{
"docid": "6561200",
"title": "Efficacy of HPV DNA testing with cytology triage and/or repeat HPV DNA testing in primary cervical cancer screening.",
"text": "BACKGROUND Primary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cervical cells with a Pap ... |
976 | Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators. | [
{
"docid": "5304891",
"title": "Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi",
"text": "Little is known about the inter-individual variation of cytokine responses to different pathogens in healthy individuals. To systematically describe cytokine respons... | [
{
"docid": "29509926",
"title": "High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.",
"text": "Membrane cholesterol modulates a variety of cell signaling pathways and functions. While cholesterol depletion by high... |
977 | Pro-inflammatory cytokines are up regulated during tumor development. | [
{
"docid": "14075252",
"title": "Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.",
"text": "Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between ... | [
{
"docid": "8702697",
"title": "miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts.",
"text": "AIMS Tumor microenvironment is a strong determinant for the acquisition of metastatic potential of cancer cells. We have recently demonstrated that cancer-associat... |
978 | Pro-inflammatory cytokines are up repressed during tumor development. | [
{
"docid": "14075252",
"title": "Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.",
"text": "Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between ... | [
{
"docid": "8702697",
"title": "miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts.",
"text": "AIMS Tumor microenvironment is a strong determinant for the acquisition of metastatic potential of cancer cells. We have recently demonstrated that cancer-associat... |
979 | Progerin induces premature aging in stem cells. | [
{
"docid": "11659421",
"title": "Human iPSC-based modeling of late-onset disease via progerin-induced aging.",
"text": "Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset di... | [
{
"docid": "16630060",
"title": "Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation",
"text": "Somatic stem cell depletion due to the accumulation of DNA damage has been implicated in the appearance of aging-related phenotypes. Hair graying, a typical sign of... |
980 | Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury. | [
{
"docid": "20128547",
"title": "Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury",
"text": "Spinal cord injuries (SCIs) in humans and experimental animals are often associated with varying degrees of spontaneous functional recovery during... | [
{
"docid": "4447055",
"title": "Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury",
"text": "Contusive spinal cord injury leads to a variety of disabilities owing to limited neuronal regeneration and functional plasticity. It is well established that an upregulation... |
984 | Pseudogene PTENP1 encodes a transcript that regulates PTEN expression. | [
{
"docid": "6828370",
"title": "A coding-independent function of gene and pseudogene mRNAs regulates tumour biology",
"text": "The canonical role of messenger RNA (mRNA) is to deliver protein-coding information to sites of protein synthesis. However, given that microRNAs bind to RNAs, we hypothesized th... | [
{
"docid": "34071621",
"title": "Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation",
"text": "Vascular disease progression is associated with marked changes in vascular smooth muscle cell (SMC) phenotype and function. SMC contractile... |
988 | Pseudoknots are not evolutionarily conserved in most eukaryotes. | [
{
"docid": "3033830",
"title": "Identification and analysis of ribonuclease P and MRP RNA in a broad range of eukaryotes",
"text": "RNases P and MRP are ribonucleoprotein complexes involved in tRNA and rRNA processing, respectively. The RNA subunits of these two enzymes are structurally related to each ... | [
{
"docid": "1383826",
"title": "Pseudoknots: RNA Structures with Diverse Functions",
"text": "RNA molecules fulfill a diverse set of biological functions within cells, from the transfer of genetic information from DNA to protein, to enzymatic catalysis. Reflecting this range of roles, simple linear stri... |
989 | Pure neural progenitor cell (NPC) populations can only be obtained from cell cultures that undergo passaging, filtration, or other isolation and cell sorting methods. | [
{
"docid": "9988425",
"title": "Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell",
"text": "Pluripotent mouse embryonic stem (ES) cells multiply in simple monoculture by symmetrical divisions. In vivo, however, stem cells are generally thought to depend on specialised cellular ... | [
{
"docid": "19756935",
"title": "A simple two-step protocol for the purification of human pancreatic beta cells",
"text": "Isolated pure human beta cells would be helpful for a number of research purposes. However, lack of beta cell-specific surface antigens has been a major problem. We aimed to develop... |
990 | Pyridostatin decreases telomere fragility in BRCA2-deficient cells. | [
{
"docid": "16472469",
"title": "Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds",
"text": "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologou... | [
{
"docid": "4899981",
"title": "Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism",
"text": "Telomeres resemble common fragile sites (CFSs) in that they are difficult-to-replicate and exhibit fragility in mitosis... |
992 | Pyridostatin deregulates G2/M progression. | [
{
"docid": "16472469",
"title": "Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds",
"text": "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologou... | [
{
"docid": "38131471",
"title": "Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.",
"text": "DNA damage is a relatively common event in the life of a cell and may lead to mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular responses that... |
994 | Pyridostatin encourages proliferation of homologous recombination - defective cells. | [
{
"docid": "16472469",
"title": "Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds",
"text": "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologou... | [
{
"docid": "6710699",
"title": "Homologous recombination resolution defect in werner syndrome.",
"text": "Werner syndrome (WRN) is an uncommon autosomal recessive disease whose phenotype includes features of premature aging, genetic instability, and an elevated risk of cancer. We used three different ex... |
996 | Pyridostatin induces checkpoint activation. | [
{
"docid": "16472469",
"title": "Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds",
"text": "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologou... | [
{
"docid": "38131471",
"title": "Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.",
"text": "DNA damage is a relatively common event in the life of a cell and may lead to mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular responses that... |
997 | Pyridostatin induces double-strand breaks accumulation. | [
{
"docid": "16472469",
"title": "Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds",
"text": "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologou... | [
{
"docid": "10874408",
"title": "Mapping Meiotic Single-Strand DNA Reveals a New Landscape of DNA Double-Strand Breaks in Saccharomyces cerevisiae",
"text": "DNA double-strand breaks (DSBs), which are formed by the Spo11 protein, initiate meiotic recombination. Previous DSB-mapping studies have used rad... |
998 | Pyridostatin prevents double-strand breaks accumulation. | [
{
"docid": "16472469",
"title": "Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds",
"text": "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologou... | [
{
"docid": "10874408",
"title": "Mapping Meiotic Single-Strand DNA Reveals a New Landscape of DNA Double-Strand Breaks in Saccharomyces cerevisiae",
"text": "DNA double-strand breaks (DSBs), which are formed by the Spo11 protein, initiate meiotic recombination. Previous DSB-mapping studies have used rad... |
999 | Pyridostatin reduces proliferation of homologous recombination - defective cells. | [
{
"docid": "16472469",
"title": "Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds",
"text": "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologou... | [
{
"docid": "6710699",
"title": "Homologous recombination resolution defect in werner syndrome.",
"text": "Werner syndrome (WRN) is an uncommon autosomal recessive disease whose phenotype includes features of premature aging, genetic instability, and an elevated risk of cancer. We used three different ex... |
1000 | Pyridostatin stabilizes the G - quadruplex in the telomeric region. | [
{
"docid": "16472469",
"title": "Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds",
"text": "G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologou... | [
{
"docid": "26118532",
"title": "The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures.",
"text": "Demonstration of the existence of G-quadruplex structures in telomeres of Stylonyc... |
1001 | R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA. | [
{
"docid": "5702790",
"title": "Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease.",
"text": "Drosophila Dicer-2 generates small interfering RNAs (siRNAs) from long double-stranded RNA (dsRNA), whereas Dicer-1 produces microRNAs (miRNAs) from pre-miRNA. What ma... | [
{
"docid": "23913146",
"title": "Molecular mechanisms that funnel RNA precursors into endogenous small-interfering RNA and microRNA biogenesis pathways in Drosophila.",
"text": "In Drosophila, three types of endogenous small RNAs-microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), and endogenous small-i... |
1002 | RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters. | [
{
"docid": "13639330",
"title": "Histone Methylation-Dependent Mechanisms Impose Ligand Dependency for Gene Activation by Nuclear Receptors",
"text": "Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actual ... | [
{
"docid": "24624992",
"title": "The expression of immediate early gene X-1 (IEX-1) is differentially induced by retinoic acids in NB4 and KG1 cells: possible implication in the distinct phenotype of retinoic acid-responsive and -resistant leukemic cells",
"text": "In a cell-type- and stimulus-dependent... |
1003 | RAD52 is involved in break-induced DNA replication (BIR). | [
{
"docid": "14332945",
"title": "Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks",
"text": "Human cancers are characterized by the presence of oncogene-induced DNA replication stress (DRS), making them dependent on repair pathways such as break-induced re... | [
{
"docid": "8577229",
"title": "Break-induced DNA replication.",
"text": "Recombination-dependent DNA replication, often called break-induced replication (BIR), was initially invoked to explain recombination events in bacteriophage but it has recently been recognized as a fundamentally important mechani... |
1004 | RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells. | [
{
"docid": "301838",
"title": "Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium",
"text": "The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing m... | [
{
"docid": "39128592",
"title": "The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.",
"text": "The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulat... |
1005 | RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells. | [
{
"docid": "301838",
"title": "Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium",
"text": "The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing m... | [
{
"docid": "39128592",
"title": "The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.",
"text": "The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulat... |
1006 | RTEL1 interacts with TRF2 through a C4C4 motif | [
{
"docid": "4926049",
"title": "TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding",
"text": "The helicase RTEL1 promotes t-loop unwinding and suppresses telomere fragility to maintain the integrity of vertebrate telomeres. An interaction between RTEL1 and PCNA is important to preve... | [
{
"docid": "7915836",
"title": "The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins",
"text": "Most cancer cells activate telomerase to elongate telomeres and achieve unlimited replicative potential. Some cancer cells cannot activate telomera... |
1008 | RUNX is not expressed in skin tissue. | [
{
"docid": "2547636",
"title": "Human epidermal stem cell function is regulated by circadian oscillations.",
"text": "Human skin copes with harmful environmental factors that are circadian in nature, yet how circadian rhythms modulate the function of human epidermal stem cells is mostly unknown. Here we... | [
{
"docid": "4380287",
"title": "Response to self antigen imprints regulatory memory in tissues",
"text": "Immune homeostasis in tissues is achieved through a delicate balance between pathogenic T-cell responses directed at tissue-specific antigens and the ability of the tissue to inhibit these responses... |
1009 | RUNX1 is downregulated or mutated in TLX1 T-ALL. | [
{
"docid": "1982286",
"title": "Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL",
"text": "The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse... | [
{
"docid": "8385277",
"title": "Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions.",
"text": "Fanconi anemia (FA) is a genetic condition associated with bone marrow (BM) failure, myelodysplasia (MDS), an... |
1011 | Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume. | [
{
"docid": "9745001",
"title": "Radioiodine treatment of multinodular non-toxic goitre.",
"text": "OBJECTIVE To investigate the long term effect of radioactive iodine on thyroid function and size in patients with non-toxic multinodular goitre. \n DESIGN Consecutive patients with multinodular non-toxic... | [
{
"docid": "26026009",
"title": "Magnetic resonance imaging for volume estimation of large multinodular goitres: a comparison with scintigraphy.",
"text": "As a result of increasing interest in non-surgical treatment for the reduction of goitre size the use of magnetic resonance (MR) imaging for volume ... |
1015 | Rapamycin delays aging in fruit flies. | [
{
"docid": "6277638",
"title": "Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster",
"text": "The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms inclu... | [
{
"docid": "6690087",
"title": "Inhibition of mammalian target of rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-kappa B activation in endothelial cells.",
"text": "We addressed the regulatory function of mammalian target of rapamyc... |
1016 | Rapamycin increases the concentration of triacylglycerols in fruit flies. | [
{
"docid": "6277638",
"title": "Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster",
"text": "The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms inclu... | [
{
"docid": "10557471",
"title": "Association between folate intake from different food sources in Norway and homocysteine status in a dietary intervention among young male adults.",
"text": "The aim of the present investigation was to study the effect of a dietary intervention which combined nutrition i... |
1018 | Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity. | [
{
"docid": "11603066",
"title": "Using Structural Information to Change the Phosphotransfer Specificity of a Two-Component Chemotaxis Signalling Complex",
"text": "Two-component signal transduction pathways comprising histidine protein kinases (HPKs) and their response regulators (RRs) are widely used t... | [
{
"docid": "1225513",
"title": "Specificity Residues Determine Binding Affinity for Two-Component Signal Transduction Systems",
"text": "UNLABELLED Two-component systems (TCS) comprise histidine kinases and their cognate response regulators and allow bacteria to sense and respond to a wide variety of si... |
1023 | Recognition of start codons depends on the translation initiation factor IF3. | [
{
"docid": "16927286",
"title": "Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation",
"text": "In bacterial translational initiation, three initiation factors (IFs 1-3) enable the selection of initiator tRNA and the start codon in the P site of the 30S ribosomal subunit. Here,... | [
{
"docid": "23342686",
"title": "Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3.",
"text": "The small ribosomal subunit is responsible for the decoding of genetic information and plays a key role in the initiation of protein synthesis. We analyzed by X-r... |
1025 | Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue. | [
{
"docid": "32408470",
"title": "Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo",
"text": "Cigarette smoking promotes body weight reduction in humans while paradoxically also promoting insulin resistance (IR) and hyperinsulinemia. However, the mechanisms ... | [
{
"docid": "36838958",
"title": "Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species.",
"text": "Uncoupling protein 1 (Ucp1), which is localized in the mitochondrial inner membrane of mammalian brown adipose tissue (BAT), generates heat by uncoupling oxidative p... |
1026 | Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction. | [
{
"docid": "3113630",
"title": "Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia-telangiectasia",
"text": "Ataxia telangiectasia is a neurodegenerative disease caused by mutation of the Atm gene. Here we report that ataxia telangiectasia mutated (ATM) deficiency cause... | [
{
"docid": "22185730",
"title": "PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta.",
"text": "Abnormal hyperphosphorylation of tau appears to be crucial in neurofibrillary degeneration in Alzheimer's disease (AD). Previous studies suggest that a down-regulation of... |
1027 | Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation. | [
{
"docid": "3113630",
"title": "Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia-telangiectasia",
"text": "Ataxia telangiectasia is a neurodegenerative disease caused by mutation of the Atm gene. Here we report that ataxia telangiectasia mutated (ATM) deficiency cause... | [
{
"docid": "22185730",
"title": "PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta.",
"text": "Abnormal hyperphosphorylation of tau appears to be crucial in neurofibrillary degeneration in Alzheimer's disease (AD). Previous studies suggest that a down-regulation of... |
1028 | Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes. | [
{
"docid": "13923140",
"title": "Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity",
"text": "Autoimmune diseases are thought to result from imbalances in normal immune physiology and regulation. Here, we show that autoimmune disease susceptibility and resistance al... | [
{
"docid": "34025053",
"title": "Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial.",
"text": "BACKGROUND Type 1 diabetes results from T-cell-mediated destruction of β cells. Findings from preclinical stud... |
1030 | Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently. | [
{
"docid": "6441369",
"title": "MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency.",
"text": "The interconversion between naive and primed pluripotent states is accompanied by drastic epigenetic rearrangements. However, it is unclear whether intrinsic epigenetic events can drive repro... | [
{
"docid": "4462419",
"title": "Derivation of novel human ground state naive pluripotent stem cells",
"text": "Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulat... |
1031 | Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis. | [
{
"docid": "12486491",
"title": "Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning",
"text": "Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather than regulatory capacity in mRNA translation. Here we identify mutations of the Rib... | [
{
"docid": "22358449",
"title": "Plzf regulates limb and axial skeletal patterning",
"text": "The promyelocytic leukaemia zinc finger (Plzf) protein (encoded by the gene Zfp145) belongs to the POZ/zinc-finger family of transcription factors. Here we generate Zfp145−/− mice and show that Plzf is essentia... |
1032 | Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpA in 2D BN-PAGE gels. | [
{
"docid": "6836086",
"title": "Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli",
"text": "Gram-negative bacteria have an outer membrane (OM) that functions as a barrier to protect the cell from toxic compounds such as antibiotics and detergents. The... | [
{
"docid": "24541180",
"title": "Isolation of intact nuclei of high purity from mouse liver.",
"text": "Current methods of nuclear isolation from liver disrupt the plasmalemmae via homogenization and separation of the nuclei by high centrifugal force (HCF) through gradients of sucrose or other substance... |
1033 | Reduction of purity of cytoplasmic membranes isolated from overexpressors is indicated by stronger spots for OmpF in 2D BN-PAGE gels. | [
{
"docid": "6836086",
"title": "Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli",
"text": "Gram-negative bacteria have an outer membrane (OM) that functions as a barrier to protect the cell from toxic compounds such as antibiotics and detergents. The... | [
{
"docid": "24541180",
"title": "Isolation of intact nuclei of high purity from mouse liver.",
"text": "Current methods of nuclear isolation from liver disrupt the plasmalemmae via homogenization and separation of the nuclei by high centrifugal force (HCF) through gradients of sucrose or other substance... |
1034 | Removal of H3K9me3 by ectopic expression of other H3K9 demethylases decreases reprogramming efficiency in SCNT experiments. | [
{
"docid": "4547102",
"title": "H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming.",
"text": "Aberrant epigenetic reprogramming often results in developmental defects in somatic cell nuclear transfer (SCNT) embryos during ... | [
{
"docid": "15803282",
"title": "Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells.",
"text": "The extremely low efficiency of human embryonic stem cell (hESC) derivation using somatic cell nuclear transfer (SCNT) lim... |
1035 | Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments. | [
{
"docid": "4547102",
"title": "H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming.",
"text": "Aberrant epigenetic reprogramming often results in developmental defects in somatic cell nuclear transfer (SCNT) embryos during ... | [
{
"docid": "15803282",
"title": "Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells.",
"text": "The extremely low efficiency of human embryonic stem cell (hESC) derivation using somatic cell nuclear transfer (SCNT) lim... |
1036 | Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments. | [
{
"docid": "4547102",
"title": "H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming.",
"text": "Aberrant epigenetic reprogramming often results in developmental defects in somatic cell nuclear transfer (SCNT) embryos during ... | [
{
"docid": "15803282",
"title": "Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells.",
"text": "The extremely low efficiency of human embryonic stem cell (hESC) derivation using somatic cell nuclear transfer (SCNT) lim... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.