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499 | Case 30 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 30.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab. and pertuzumab) + Operation + Post-. operative radiation therapy.. 179. Pathology Report. Ductal Carcinoma In Situ. . 1. Post-chemotherapy status.. . 2. Size of tumor: 2.0 cm (ypTis).. . 3. Nuclear ... |
506 | Case 30 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 172 173 174 175 176 177. 178 |
511 | Case 30 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/31 years old, pre-menopause.. Self-detected palpable mass lesion on outer. inner portion of right breast.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 30.2. |
500 | Case 30 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation + Post-operative radiation ther. apy + Letrozole 2.5 mg/day.. Operation. Left breast conserving surgery, sentinel lymph. ponent: absent).. 4. Skin: no involvement of tumor.. 5. Surgical margins:. . (a) superior margin: 15 mm.. . (b) inferior margin: 15 mm.. . (c) medial margin: 1... |
507 | Case 30 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 165, 166, 167 and 168.. 30.3. |
512 | Case 30 | Patient History | HR(+) HER2(-) Breast Cancer | s/p Left optic nerve palsy, hypertension, s/p. right rotator cuff tear operation.. 30.2. |
501 | Case 30 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 30.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab and. pertuzumab) + Operation + Post-operative radia. tion therapy + Trastuzumab and pertuzumab.. 3. Histologic grade: not applicable.. 4. Intraductal component: absent.. 5. Skin: no involvement of tumor.... |
508 | Case 30 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 202 203. 204. HR(−) HER2(+) Breast Cancer. 540. . . Y. Kwon et al.. 541. 30.3. . After Neoadjuvant. Chemotherapy. 205 206. 207. 30.4. |
513 | Case 30 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/41 years old, pre-menopause.. Self-detected palpable mass and nipple dis. charge on left breast.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 30.2. |
502 | Case 30 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 30.1. . Courses of Treatment. Neoadjuvant chemotherapy (#2 cycles of. doxorubicin and cyclophosphamide + #3. cycles of paclitaxel) + Operation + Adjuvant. capecitabine.. Operation. 224. Pathology Report. Invasive Ductal Carcinoma. 1. Post-chemotherapy status.. 2. Size of tumor: 3.5 cm (ypT2).. 3. Histologic grad... |
509 | Case 30 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 216 217. 218. . E. S. Lee et al.. 683. After Neoadjuvant. Chemotherapy. 219 220 221 222. 223. 30.3. |
514 | Case 30 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/69 years old, post-menopause.. Self-detected palpable mass lesion on left. breast.. No family history.. h/o Tuberculosis, s/p thoracic vertebra com. pression fracture.. 30.2. |
503 | Case 30 | Courses of Treatment | Local Recurrence | 30.1. . Courses of Treatment. Right breast IDC → Operation → Adjuvant. therapy → Left breast recurrence (IDC).. Primary Treatment. 203 204 205. 206. . . . . Local Recurrence. 800. a. b. c. d. . Operation. 207. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 2.2 cm (pT2).. 2. Histologic grade: 2/3 (tub... |
515 | Case 30 | Patient History | Local Recurrence | Patient History and Progress. Female/89 years old, post-menopause.. Screen detected mass lesion on right breast 1. o’clock direction.. Outside result of biopsy: Invasive ductal. carcinoma.. No family history.. Hypertension, Hypothyroidism, s/p Cardiac. stent insertion (angina).. s/p Shoulder ligament rupture operation.... |
504 | Case 30 | Courses of Treatment | Metastatic Breast Cancer | 30.1. . Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Bone metastasis.. Positive %. Estrogen. receptor. Strong (7/8). 3. 1/3–2/3. Progesterone. receptor. Strong (7/8). 3. 1/3–2/3. C-erbB2. Negative (0). Ki-67. Positive in. 5% of tumor. cells. Adjuvant Therapy. Tamoxifen 20 mg/day.. Treatm... |
516 | Case 30 | Patient History | Metastatic Breast Cancer | Patient History and Progress. Female/50 years old, pre-menopause.. No family history.. Hepatitis B virus carrier, s/p myomectomy.. 30.2. |
517 | Case 31 | Courses of Treatment | Carcinoma In Situ | 31.1. . Courses of Treatment:. Operation. Operation. 146. 147. Pathology Report. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTis. . 1. Size of tumor: 2.0 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: papillary/micropapil. lary/cribriform.. E. S. ... |
524 | Case 31 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 144. 145. 31.3. |
529 | Case 31 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/31 years old, pre-menopause.. Screen detected calcification on left breast. 11 o’clock direction.. Outside result of mammotome biopsy: Ductal. carcinoma in situ.. No family history.. No comorbidities.. BRCA 1 and 2: Not detected.. 31.2. |
518 | Case 31 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 31.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of doxorubicin and cyclophosphamide. followed by #4 cycles of docetaxel and trastu. zumab) + Post-operative radiation ther. apy + Trastuzumab + Letrozole 2.5 mg/day.. 184. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 1... |
525 | Case 31 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 180 181 182. 183. 31.3. |
530 | Case 31 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/69 years old, post-menopause.. Self-detected nipple retraction on left breast.. No family history.. Hypertension.. 31.2. |
519 | Case 31 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation. +. Adjuvant. chemotherapy. (#4 cycles of docetaxel & . cyclophosphamide) +. Post-operative radiation therapy + Letrozole. 2.5 mg/day.. Operation. Right breast conserving surgery, sentinel lymph. . (c) medial margin: 10 mm.. . (d) lateral margin: 10 mm.. . (e) deep margin: <1 mm from... |
526 | Case 31 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 170, 171, 172 and 173.. 31.3. |
531 | Case 31 | Patient History | HR(+) HER2(-) Breast Cancer | niece.. S/P. Hysterectomy. and. salpingo-oophorectomy.. BRCA 1 exon 9-13 deletion, exon 2-6. deletion.. 31.2. |
520 | Case 31 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 31.1. . Operation. 213. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 2.1 cm (pT2).. 2. Histologic grade: 3/3 (tubule formation: 3/3,. nuclear pleomorphism: 3/3, mitotic count:. 3/3, 5/HPF).. 3. Intraductal component: present, intratu. moral/extratumoral (50%) (nuclear grade:. high, necrosis: pres... |
527 | Case 31 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 209 210 211. 212. . HR(−) HER2(+) Breast Cancer |
532 | Case 31 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/74 years old, post-menopause.. Screen detected mass lesion on left breast 1. o’clock direction.. No family history.. Hypertension.. 31.2. |
521 | Case 31 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 31.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and cyclophosphamide + #4. cycles of docetaxel) + Operation + Post-. operative radiation therapy + Adjuvant. capecitabine.. Operation. 233. Pathology Report. Invasive Ductal Carcinoma. 1. Post-chemotherapy status.. 2. Size of ... |
528 | Case 31 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 225 226 227. 228. E. S. Lee et al.. 687. . . . . HR(−) HER2(−) Breast Cancer. 688. . After Neoadjuvant. Chemotherapy. 229 230 231. 232. 31.3. |
533 | Case 31 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/41 years old, pre-menopause.. Self-detected mass lesion on right breast.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected, STK11. VUS (variant of uncertain).. 31.2. |
522 | Case 31 | Courses of Treatment | Local Recurrence | 31.1. . Courses of Treatment. Right breast Papillary carcinoma in situ→. Operation → Right breast recurrence (DCIS).. Primary Treatment. 212 213 214. 215. Operation. . . 216 217. 218. Pathology Report. <Right>. Y. Kim et al.. 803. . . . . . Papillary carcinoma in situ. . 1. Size of tumor: 5.0 cm (pTis).. . 2. Nuc... |
534 | Case 31 | Patient History | Local Recurrence | Patient History and Progress. Female/49 years old, pre-menopause.. Screen detected mass lesion on right breast 1. o’clock direction.. No family history.. No comorbidities.. 31.2. |
523 | Case 31 | Courses of Treatment | Metastatic Breast Cancer | Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Lung metastasis.. Primary Treatment. receptor. Negative (0/8). 0. 0. C-erbB2. Negative (0). Ki-67. Positive in. 85% of tumor. cells. Adjuvant Therapy. Adjuvant chemotherapy #6 cycles (Fluorouracil. & Doxorubicin & Cyclophosphamide).. Post-opera... |
535 | Case 31 | Patient History | Metastatic Breast Cancer | BRCA 1: positive for deleterious mutation.. S/p bilateral salpingo-oophorectomy.. 31.2. |
536 | Case 32 | Courses of Treatment | Carcinoma In Situ | 32.1. . Courses of Treatment. Operation + Postoperative radiation therapy.. Operation. 151. 152. Pathology Report. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTis. . 1. Size of tumor: 4.0 cm (pTis).. . 2. Nuclear grade: high.. . 3. Necrosis: present.. . 4. Architectural pattern: . micropap... |
543 | Case 32 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 148 149. 150. 32.3. |
548 | Case 32 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/72 years old, post-menopause.. Screen detected mass lesion on right breast. 8 o’clock direction.. Outside result of biopsy: Ductal carcinoma in. situ.. No family history.. No comorbidities.. 32.2. |
537 | Case 32 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 32.1. . Courses of Treatment. Neoadjuvant chemotherapy (#3 cycles of. docetaxel. and. trastuzumab. and. pertu. zumab) + Operation + Post-operative radia. tion therapy + Trastuzumab emtansine +. Letrozole 2.5 mg/day.. Operation:. Left. axillary. lymph. node. . dissection.. Pathology Report. Metastatic Ductal C... |
544 | Case 32 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 185 186 187 188. 189. 32.3. |
549 | Case 32 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/74 years old, post-menopause.. Self-detected mass lesion on left axillary.. No family history.. S/P Tuberculosis, asthma.. 32.2. |
538 | Case 32 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation + Post-operative radiation ther. apy + Letrozole 2.5 mg/day.. Operation. Right breast conserving surgery, sentinel lymph. ponent: absent).. 4. Skin: no involvement of tumor.. 5. Surgical margins:. . (a) superior margin: 20 mm.. . (b) inferior margin: 40 mm.. . (c) medial margin: ... |
545 | Case 32 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 175, 176, 177 and 178.. 32.3. |
550 | Case 32 | Patient History | HR(+) HER2(-) Breast Cancer | o’clock direction.. No family history.. Hypertension, s/p bronchiectasis, s/p left hip. arthroplasty.. 32.2. |
539 | Case 32 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 32.1. . Courses of Treatment. Neoadjuvant chemotherapy (#5 cycles of. docetaxel and carboplatin and trastuzumab and. pertuzumab after followed #1 cycle of trastu. zumab and pertuzumab) + Operation + Post-. operative radiation therapy + Trastuzumab.. Operation. 220. Pathology Report. No residual tumor with stroma... |
546 | Case 32 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 214 215. 216. 32.3. . After Neoadjuvant. Chemotherapy. 217 218. 219. Y. Kwon et al.. 547. . . . . HR(−) HER2(+) Breast Cancer. 548. . . 32.4. |
551 | Case 32 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/55 years old, post-menopause.. Screen detected mass lesion on right breast 8. o’clock direction.. No family history.. Hypertension, thyroid nodules.. 32.2. |
540 | Case 32 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 32.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and . cyclophosphamide + #4 cycles. of docetaxel) + Operation + Post-operative. radiation therapy + Adjuvant capecitabine.. . . . HR(−) HER2(−) Breast Cancer. 694. . . Operation. 242. Pathology Report. Invasive Ductal Carcinoma. 1... |
547 | Case 32 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 234 235 236. 237. . HR(−) HER2(−) Breast Cancer. 692. . . . . . E. S. Lee et al.. 693. . After Neoadjuvant. Chemotherapy. 238 239 240. 241. 32.3. |
552 | Case 32 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/49 years old, pre-menopause.. Self-detected mass lesion on left breast.. Family history of breast cancer, aunt and. cousin (paternal).. Family history of prostate cancer, father.. Hyperthyroidism.. BRCA 1 and 2 mutation: Not detected.. 32.2. |
541 | Case 32 | Courses of Treatment | Local Recurrence | 32.1. . Courses of Treatment. Right breast DCIS → Operation → Adjuvant. therapy → Right breast recurrence (tubular. carcinoma + DCIS).. Primary Treatment. Operation. Aug. 2014 Right breast wide excision (outside).. Pathology Report. Ductal carcinoma in situ involving intraductal. papilloma. . 1. Nuclear grade: low.. ... |
553 | Case 32 | Patient History | Local Recurrence | Patient History and Progress. Female/42 years old, pre-menopause.. Screen detected mass lesion on right breast. . 12 o’clock direction.. Outside result of lumpectomy: Ductal carci. noma in situ.. No family history.. No comorbidities.. BRCA 2 VUS (variant of uncertain).. 32.2. |
542 | Case 32 | Courses of Treatment | Metastatic Breast Cancer | Courses of Treatment. Left breast cancer → Operation → Adjuvant. therapy → Lung metastasis.. Primary Treatment. receptor. Intermediate. (4/7). 2. 10%–1/3. Progesterone. receptor. Strong (6/7). 3. 1/3–2/3–. C-erbB2. Positive (3+). Ki-67. Positive in. 20% of tumor. cells. Y. Kwon et al.. & Doxorubicin & Cyclophosphamide)... |
554 | Case 32 | Patient History | Metastatic Breast Cancer | Patient History and Progress. Female/49 years old, peri-menopause.. No family history.. 32.2. |
555 | Case 33 | Courses of Treatment | Carcinoma In Situ | 33.1. . Courses of Treatment:. Operation. Operation. 155. 156. Pathology Report. <First operation>. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTis. . 1. Size of tumor: 0.5 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: papillary/cribriform.. . 5. ... |
562 | Case 33 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 153. 154. 33.3. |
567 | Case 33 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/68 years old, post-menopause.. Bloody nipple discharge from right breast.. No family history.. S/P Hysterectomy.. 33.2. |
556 | Case 33 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab. and pertuzumab) + Operation + Post-. operative. radiation. ther. apy + Trastuzumab + Tamoxifen 20 mg/day.. 194. Pathology Report. Invasive ductal carcinoma, histologic grade 2.. No residual tumor with stromal ... |
563 | Case 33 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 190 191 192. 193. 33.3. |
568 | Case 33 | Patient History | HR(+) HER2(+) Breast Cancer | Self-detected palpable mass lesion on left. breast.. No family history.. No comorbidities.. 33.2. |
557 | Case 33 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation + Post-operative radiation ther. apy + Tamoxifen 20 mg/day.. Y. Kim et al.. micropapillary/cribriform, extensive intra. ductal component: present).. 5. Skin: no involvement of tumor.. HR(+) HER2(−) Breast Cancer. . (e) deep margin: 3 mm.. . (f) superficial margin: 5 mm.. Y. Kim et... |
564 | Case 33 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 180, 181, 182, 183 and 184.. 33.3. |
569 | Case 33 | Patient History | HR(+) HER2(-) Breast Cancer | Restless legs.. 33.2. |
558 | Case 33 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 33.1. . tion therapy + Trastuzumab.. Operation. 228. Pathology Report. . 1. No residual tumor with foamy histiocytic. collection.. . (a) Post-chemotherapy status.. . (b) Lymph nodes: no metastasis in four axil. lary lymph nodes (ypN0(sn)) (sentinel. LN: 0/4).. . (c) Microcalcification:. present,. tumoral/. non-tu... |
565 | Case 33 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 221 222 223. 224. HR(−) HER2(+) Breast Cancer. . HR(−) HER2(+) Breast Cancer. 552. . 33.3. . After Neoadjuvant. Chemotherapy. 225 226. 227. Y. Kwon et al. |
570 | Case 33 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/63 years old, post-menopause.. Self-detected palpable mass lesion on left. breast 2 o’clock direction.. No family history.. Hypertension, chronic kidney disease, ven. tricular premature contraction.. 33.2. |
559 | Case 33 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 33.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and cyclophosphamide + #4. cycles of docetaxel) + Operation + Post-. operative radiation therapy.. Operation. 251. Pathology Report. Atypical ductal hyperplasia, focal. . 1. Post-chemotherapy status.. . 2. Lymph nodes: no metast... |
566 | Case 33 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 243 244 245. 246. . . HR(−) HER2(−) Breast Cancer. 696. . . . . After Neoadjuvant. Chemotherapy. 247 248 249. 250. 33.3. |
571 | Case 33 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/52 years old, post-menopause.. Screen detected mass lesion on left breast 11. o’clock direction.. No family history.. s/p cervical cancer (stage 0).. BRCA 1 and 2 mutation: Not detected.. 33.2. |
560 | Case 33 | Courses of Treatment | Local Recurrence | 33.1. . Courses of Treatmaent. Left breast IDC → Neoadjuvant chemotherapy. → Operation → Adjuvant therapy → Left breast. recurrence (IDC).. Primary Treatment. 225 226 227. 228. Neoadjuvant Chemotherapy. Neoadjuvant chemotherapy #6 cycles of trastu. zumab and pertuzumab and docetaxel and. carboplatin.. Operation. . 2... |
572 | Case 33 | Patient History | Local Recurrence | Patient History and Progress. Female/45 years old, pre-menopause.. Screen detected mass lesion on upper inner. portion of left breast.. Outside result of biopsy: Invasive ductal. carcinoma.. Family history of breast cancer, mother at her. 50 years old.. S/P. Hysterectomy,. s/p. bilateral. breast. augmentation.. 33.2. |
561 | Case 33 | Courses of Treatment | Metastatic Breast Cancer | Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Bone metastasis.. Primary Treatment. Estrogen. receptor. Strong (8/8). 3. >2/3. Progesterone. receptor. Intermediate. (5/8). 2. 10%–. 1/3. Result. Intensity. Positive %. C-erbB2. Equivocal (2+). Ki-67. Positive in 7%. of tumor cells. SISH. Posi... |
573 | Case 33 | Patient History | Metastatic Breast Cancer | |
574 | Case 34 | Courses of Treatment | Carcinoma In Situ | 34.1. . Courses of Treatment:. Operation. Operation. 161. 162. Pathology Report. <First operation>. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTis. . 1. Size of tumor: 0.5 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: papillary/cribriform.. . 5. ... |
581 | Case 34 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 157 158 159. 160. 34.3. |
586 | Case 34 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/53 years old, pre-menopause.. Screen detected mass lesion on upper outer of. right breast.. No family history.. S/P Total gastrectomy (gastric cancer), micro. papillary thyroid carcinoma (follow-up).. BRCA 1 and 2: Not examination.. 34.2. |
575 | Case 34 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 34.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab. and pertuzumab) + Operation + Post-. operative radiation therapy + Trastuzumab. and Pertuzumab + Letrozole 2.5 mg/day.. 201. Pathology Report. Invasive ductal carcinoma, histologic grade 2.. No resid... |
582 | Case 34 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 195 196 197 198 199. 200. 34.3. |
587 | Case 34 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/55 years old, post-menopause.. Self-detected palpable mass lesion on right. breast 9 o’clock direction.. No family history.. No comorbidities.. 34.2. |
576 | Case 34 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | 34.1. . Courses of Treatment. Operation. Right nipple–areolar complex sparing mastec. tomy with immediate implant reconstruction,. sentinel lymph node biopsy, left nipple–areo. lar complex sparing mastectomy with immedi. ate implant reconstruction (Figs. 190, 191 and. 192).. Pathology Report. [Right]. Invasive Duct... |
583 | Case 34 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 186, 187, 188 and 189.. 34.3. |
588 | Case 34 | Patient History | HR(+) HER2(-) Breast Cancer | Patient History and Progress. Female/43 years old, pre-menopause.. Screen for high risk for breast cancer.. Family history of breast cancer, mother.. Pancreatic cancer, maternal uncle.. No comorbidities.. BRCA 1 mutation carrier.. 34.2. |
577 | Case 34 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 34.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4 cycles. of. doxorubicin. +. cyclophosphamide). +. Operation + Trastuzumab.. Operation. 233. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 1.5 cm (pT1c(Paget)).. 2. Histologic grade: 3/3 (tubule formation: 3/3,. nuclear pleomorphism:... |
584 | Case 34 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 229 230 231. 232. . HR(−) HER2(+) Breast Cancer. 556. . . . . 34.3. |
589 | Case 34 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/54 years old, post-menopause.. Self-detected palpable mass lesion on left. breast.. No family history.. S/P. unilateral. salpingo-oophorectomy,. dyslipidemia.. HR(−) HER2(+) Breast Cancer. 554. a. b. . Y. Kwon et al.. 555. 34.2. |
578 | Case 34 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 34.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#1. cycles of docetaxel and cyclophosphamide,. stop d/t mucositis).. Operation. 255. Pathology Report. Invasive Ductal Carcinoma associated with. paraffinoma. 1. Size of tumor: 3.0 cm (pT2).. . . E. S. Lee et al.. 701. 2. Histologic grade: 3/3 (tubul... |
585 | Case 34 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 252 253. 254. . . HR(−) HER2(−) Breast Cancer. 700. 34.3. |
590 | Case 34 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/79 years old, post-menopause.. Screen detected mass lesion on left breast 12. o’clock direction.. No family history.. S/P paraffin injection, s/p appendectomy, s/p. hysterectomy, s/p hemicolectomy (colon cancer).. S/P radical total gastrostomy (advanced gas. tric cancer).. BRCA 1 a... |
579 | Case 34 | Courses of Treatment | Local Recurrence | 34.1. . Courses of Treatment. Right breast IDC → Operation → Adjuvant. therapy → Right breast recurrence (IDC).. Primary Treatment. 233 234. 235. Operation. 236. Pathology Report. Invasive Ductal Carcinoma. 1. Size of invasive component: 0.7 cm (pT1b).. 2. Size of intraductal component: 1.0 cm.. 3. Histologic grade... |
591 | Case 34 | Patient History | Local Recurrence | Patient History and Progress. Female/47 years old, pre-menopause.. Screen detected microcalcification on upper. outer portion of right breast.. Family history of ovarian cancer mother.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 34.2. |
580 | Case 34 | Courses of Treatment | Metastatic Breast Cancer | Courses of Treatment. Left breast cancer → Operation → Adjuvant. therapy → Right pleural, liver, right adrenal. gland, bone metastasis → Brain metastasis.. Primary Treatment. (0/8). 0. 0. Progesterone. receptor. Negative. (0/8). 0. 0. C-erbB2. Equivocal. (2+). Ki-67. Positive. in 46% of. tumor. cells. SISH. Positive. A... |
592 | Case 34 | Patient History | Metastatic Breast Cancer | No family history.. 34.2. |
593 | Case 35 | Courses of Treatment | Carcinoma In Situ | 35.1. . Courses of Treatment. Operation + Tamoxifen 20 mg/day for 5 years.. Operation. 165. 166. Pathology Report. Lobular carcinoma in situ, pathological TN. category (AJCC 2017): pTis. . 1. Size of tumor: 0.5 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: solid.. . 5. ... |
600 | Case 35 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 163. 164. 35.3. |
605 | Case 35 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/59 years old, post-menopause.. Screen detected ductal dilatation on left breast. 12 o’clock direction.. No family history.. S/P Hysterectomy and bilateral salpingo-. oophorectomy, S/P total thyroidectomy (thyroid. cancer), hypertension.. 35.2. |
594 | Case 35 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 35.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab. S. Park et al.. 209. 210. Pathology Report. Invasive ductal carcinoma, histologic grade 3.. No residual tumor with stromal degeneration.. . 1. Post-chemotherapy status.. . 2. Lymph nodes: no metastasis in... |
601 | Case 35 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 202 203 204 205 206 207. 208. 35.3. |
606 | Case 35 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/39 years old, pre-menopause.. Self-detected skin change and palpable mass. lesion on right breast 9:30 o’clock direction.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 35.2. |
595 | Case 35 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | 35.1. . cribriform/solid/comedo, extensive intra. ductal component: present).. 5. Skin: no involvement of tumor.. 6. Surgical margins:. . (a) superior margin: 15 mm.. . (b) inferior margin: 15 mm.. . (c) medial margin: 10 mm.. . (d) lateral margin: 10 mm.. . (e) deep margin: 2 mm.. . (f) superficial margin: 2... |
602 | Case 35 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 193, 194, 195, 196 and 197.. Y. Kim et al. |
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