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607 | Case 35 | Patient History | HR(+) HER2(-) Breast Cancer | Patient History and Progress. Female/48 years old, pre-menopause.. Screen detected mass lesion on left breast 4. o’clock direction.. Family history of breast cancer, maternal aunt.. No comorbidities.. BRCA 1 and 2 mutation: no examination.. 35.2. |
596 | Case 35 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 35.1. . Courses of Treatment. Neoadjuvant chemotherapy (#5 cycles of. docetaxel. and. trastuzumab. and. pertu. zumab) + Operation + Post-operative radiation. therapy + Trastuzumab and pertuzumab.. Operation. 242. Pathology Report. Microinvasive Ductal Carcinoma. 1. Post-chemotherapy status.. 2. Size of invasive... |
603 | Case 35 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 234 235 236. 237. Y. Kwon et al.. 559. . . . HR(−) HER2(+) Breast Cancer. 560. . . Y. Kwon et al.. 561. 35.3. . After Neoadjuvant. Chemotherapy. 238 239 240. 241. 35.4. |
608 | Case 35 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/73 years old, post-menopause.. Self-detected palpable mass lesion on right. breast.. Family history of breast cancer, cousin. (maternal).. s/p cholecystectomy, s/p unilateral salpingo-. oophorectomy, hypertension, diabetes mellitus.. BRCA 1 and 2 mutation: Not detected.. 35.2. |
597 | Case 35 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 35.1. . Courses of Treatment. Operation. +. Adjuvant. chemotherapy. (#4 cycles of doxorubicin and cyclophospha. mide) + Post-operative radiation therapy.. Operation. 259. Pathology Report. Invasive Ductal Carcinoma with apocrine. differentiation. 1. Size of tumor: 1.1 cm (pT1c).. 2. Histologic grade: 3/3 (tubule f... |
604 | Case 35 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic Findings. 256 257. 258. 35.3. |
609 | Case 35 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/75 years old, post-menopause.. Screen detected mass lesion on left breast 2. o’clock direction.. No family history.. Hypertension, Hyperlipidemia, s/p hysterec. tomy, arrhythmia (s/p operation).. 35.2. |
598 | Case 35 | Courses of Treatment | Local Recurrence | 35.1. . Courses of Treatment. Right breast IDC → Neoadjuvant chemotherapy. → Operation → Adjuvant therapy → Right. breast recurrence (DCIS).. Primary Treatment. Operation. First Operation (Aug. 2004) Left breast conserv. ing surgery, sentinel lymph node biopsy.. Pathology Report. Invasive Ductal Carcinoma. 1. Size o... |
610 | Case 35 | Patient History | Local Recurrence | Patient History and Progress. Female/53 years old, peri-menopause.. Screen detected mass lesion on left breast. subareola.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 35.2. |
599 | Case 35 | Courses of Treatment | Metastatic Breast Cancer | 35.1. . Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Bone metastasis.. Primary Treatment. Strong (8/8). 3. >2/3. Progesterone. receptor. Negative (0/8). 0. 0. C-erbB2. Negative (1+). Ki-67. Positive in. 16% of tumor. cells. Oncotype Dx test: 23 (Recurrence Score).. Adjuvant Therapy. Post... |
611 | Case 35 | Patient History | Metastatic Breast Cancer | Patient History and Progress. Female/51 years old, pre-menopause.. No family history.. S/p. hysterectomy. &. Left. salpingo-. oophorectomy (benign), s/p total hip replacement. arthroplasty.. 35.2. |
612 | Case 36 | Courses of Treatment | Carcinoma In Situ | 36.1. . Courses of Treatment:. Operation. Operation. 169. 170. Pathology Report. Lobular carcinoma in situ. . 1. Size of tumor: 0.5 cm.. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: solid.. . 5. Skin: no involvement of tumor.. . 6. Surgical margins:. . (a) superior margin: 10 mm... |
619 | Case 36 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 167. 168. 36.3. |
624 | Case 36 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/47 years old, pre-menopause.. Screen detected mass lesion on right breast. 11 o’clock direction.. No family history.. No comorbidities.. 36.2. |
613 | Case 36 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 36.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of docetaxel and cyclophosphamide and. trastuzumab) + Post-operative radiation ther. apy + Trastuzumab + Tamoxifen 20 mg/day.. 215. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 1.5 cm (pT1c).. 2. Histologic grade: 3/3 (t... |
620 | Case 36 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 211 212 213. 214. 36.3. |
625 | Case 36 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/42 years old, pre-menopause.. Self-detected palpable mass lesion on left. breast 5:30 o’clock direction.. No family history.. S/P Right pneumonectomy (lung cancer).. BRCA 1 and 2 mutation: Not examination.. 36.2. |
614 | Case 36 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | 36.1. . Courses of Treatment. Operation + Post-operative radiation ther. apy + Tamoxifen 20 mg/day.. Operation. Right breast conserving surgery, sentinel lymph. micropapillary/cribri. form, extensive intraductal component:. present).. 4. Skin: no involvement of tumor.. 5. Surgical margins:. . (a) superior margi... |
621 | Case 36 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 199, 200, 201, 202 and 203.. 36.3. |
626 | Case 36 | Patient History | HR(+) HER2(-) Breast Cancer | Patient History and Progress. Female/50 years old, pre-menopause.. Screen detected mass lesion on right breast 10. o’clock direction.. No family history.. s/p endometrial curettage.. 36.2. |
615 | Case 36 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 36.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab. and pertuzumab) + Operation + Post-. operative radiation therapy + Trastuzumab.. 245. Pathology Report. . 1. No residual tumor with foamy histiocytic. collection.. . (a) Post-chemotherapy status.. . ... |
622 | Case 36 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 243. 244. 36.3. |
627 | Case 36 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/63 years old, post-menopause.. Screen detected mass lesion on left breast 2. o’clock direction.. No family history.. Hypertension, chronic renal failure, ventricu. lar premature contraction.. S/P cholecystectomy (due to stone).. 36.2. |
616 | Case 36 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 36.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and . cyclophosphamide + #4 cycles. of docetaxel) + Operation + Post-operative. radiation therapy.. Operation. 267. Pathology Report. . 1. No residual tumor with foamy histiocytic. collection.. . (a) Post-chemotherapy status.. . ... |
623 | Case 36 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic Findings. 260 261 262. 263. HR(−) HER2(−) Breast Cancer. 704. . . . . E. S. Lee et al.. 705. . HR(−) HER2(−) Breast Cancer. 706. . After Neoadjuvant Chemotherapy. 264 265. 266. 36.3. |
628 | Case 36 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/46 years old, pre-menopause.. Self-detected palpable mass lesion on left. axillary.. Family history of breast cancer, aunt. (maternal).. Hepatitis B virus carrier.. BRCA 1 and 2 mutation: Not detected, RET. VUS (variant of uncertain).. 36.2. |
617 | Case 36 | Courses of Treatment | Local Recurrence | 36.1. . Courses of Treatment. Right breast DCIS → Operation → Left breast. recurrence (DCIS).. Primary Treatment. 244. Operation. 245. Pathology Report. Ductal Carcinoma In Situ. . 1. Post mammotome biopsy status.. Local Recurrence. 818. . a. b. . . 2. Size of tumor: 0.2 cm, residual.. . 3. Nuclear grade: low.. . 4... |
629 | Case 36 | Patient History | Local Recurrence | Patient History and Progress. Female/48 years old, pre-menopause.. Screen detected mass lesion on right breast 10. o’clock direction.. Outside result of biopsy: Papillary carcinoma. in situ.. No family history.. s/p bilateral breast augmentation.. BRCA 1 and 2 mutation: Not detected.. 36.2. |
618 | Case 36 | Courses of Treatment | Metastatic Breast Cancer | Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Lung metastasis.. Primary Treatment. Estrogen. receptor. Strong (7/7). 3. >2/3. Progesterone. receptor. Intermediate. (5/7). 2. 1/3–2/3. Result. Intensity. Positive %. C-erbB2. Equivocal. (2+). Ki-67. Positive in. 10% of tumor. cells. SISH. Neg... |
630 | Case 36 | Patient History | Metastatic Breast Cancer | mellitus.. 36.2. |
631 | Case 37 | Courses of Treatment | Carcinoma In Situ | 37.1. . Courses of Treatment:. Operation. Operation. 173. 174. Pathology Report. Lobular carcinoma in situ. . 1. Size of tumor: 2.0 cm.. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: solid.. . 5. Skin: no involvement of tumor.. . 6. Surgical margins:. . (a) superior margin: posit... |
637 | Case 37 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 171. 172. 37.3. |
641 | Case 37 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/46 years old, pre-menopause.. Screen detected mass lesion on left breast. 12 o’clock direction.. Outside result of biopsy: Lobular carcinoma. in situ.. No family history.. No comorbidities.. 37.2. |
632 | Case 37 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of docetaxel & cyclophosphamide) +. Post-operative radiation therapy + Tamoxifen. 20 mg/day.. Operation. Left breast conserving surgery, sentinel lymph. ductal component: present).. 4. Skin: no involvement of tumor.. 5. Surgical margins:. . (a) sup... |
638 | Case 37 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 205, 206, 207 and 208.. 37.3. |
642 | Case 37 | Patient History | HR(+) HER2(-) Breast Cancer | 4–5 o’clock direction.. No family history.. Hypertension,. s/p. Lumbar. spine. disc. operation.. 37.2. |
633 | Case 37 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 37.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab. and pertuzumab) + Operation + Post-. operative radiation therapy + Trastuzumab.. 253. Pathology Report. Ductal Carcinoma In Situ. 1. Post-chemotherapy status.. 2. Size of tumor: 0.5 cm (ypTis).. 3. ... |
639 | Case 37 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 246 247. 248. Y. Kwon et al.. 567. . . . HR(−) HER2(+) Breast Cancer. 568. 37.3. . After Neoadjuvant. Chemotherapy. 249 250 251. 252. . Y. Kwon et al.. 569. . . . 37.4. |
643 | Case 37 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/63 years old, post-menopause.. Self-detected nipple discharge on left breast.. No family history.. S/P Total hysterectomy, s/p right lung lobec. tomy (benign), diabetes mellitus.. 37.2. |
634 | Case 37 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 37.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and cyclophosphamide + #4. cycles of docetaxel) + Operation + Post-. operative radiation therapy + Adjuvant. capecitabine.. Operation. 276. Pathology Report. Invasive Ductal Carcinoma. 1. Post-chemotherapy status.. 2. Size of ... |
640 | Case 37 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 268 269 270. 271. . . . . . E. S. Lee et al.. 709. . After Neoadjuvant. Chemotherapy. 272 273 274. 275. 37.3. |
644 | Case 37 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/46 years old, pre-menopause.. Self-detected palpable mass lesion on right breast.. Family history of breast cancer, aunt (maternal).. s/p myomectomy.. BRCA 1 and 2 mutation: Not detected.. 37.2. |
635 | Case 37 | Courses of Treatment | Local Recurrence | 37.1. . Courses of Treatment. Left breast DCIS→ Operation → Adjuvant ther. apy → Left breast recurrence (DCIS).. Primary Treatment. 249 250. 251. Operation. 252. Local Recurrence. 820. Pathology Report. Ductal Carcinoma In Situ. . 1. Size of tumor: 3.0 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: present..... |
645 | Case 37 | Patient History | Local Recurrence | Patient History and Progress. Female/43 years old, pre-menopause.. Screen detected mass lesion on left breast 7. o’clock direction.. Outside result of biopsy: ductal carcinoma in. situ.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 37.2. |
636 | Case 37 | Courses of Treatment | Metastatic Breast Cancer | 37.1. . Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Lung metastasis.. Primary Treatment. Estrogen. receptor. Intermediate. (6/8). 2. 1/3–2/3. Progesterone. receptor. Intermediate. (6/8). 2. 1/3–2/3. C-erbB2. Positive (3+). Ki-67. Positive in. 27% of tumor. cells. Metastatic Breast Cance... |
646 | Case 37 | Patient History | Metastatic Breast Cancer | Patient History and Progress. Female/59 years old, post-menopause.. No family history.. Hypertension, s/p right vertebral artery, tran. sient ischemic attack.. 37.2. |
647 | Case 38 | Courses of Treatment | Carcinoma In Situ | 38.1. . Courses of Treatment. Neoadjuvant chemotherapy #6 cycles (Docetaxel. and. Carboplatin. and. Trastuzumab. and. Pertuzumab) + Operation + Postoperative radia. tion therapy + Tamoxifen 20 mg/day for 5 years. + Trastuzumab for 1 year.. Operation. 180. 181. Pathology Report. Right.. Lobular carcinoma in situ. . 1.... |
653 | Case 38 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 175 176 177 178. 179. 38.3. |
657 | Case 38 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/51 years old, pre-menopause.. Screen detected mass and microcalcification. on upper outer left breast.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected, POLE. VUS (variant of uncertain).. 38.2. |
648 | Case 38 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | 38.1. . Courses of Treatment. Operation + Post-operative radiation ther. apy + Letrozole 2.5 mg/day.. HR(+) HER2(−) Breast Cancer. extensive intraductal component: present).. 5. Skin: no involvement of tumor.. 6. Surgical margins:. . (a) superior margin: 20 mm.. . (b) inferior margin: 7 mm.. . (c) medial margi... |
654 | Case 38 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 210, 211, 212, 213 and 214.. 38.3. |
658 | Case 38 | Patient History | HR(+) HER2(-) Breast Cancer | Patient History and Progress. Female/57 years old, post-menopause.. Screen detected mass lesion on left breast 2. o’clock direction.. No family history.. Diabetes mellitus, dyslipidemia, s/p cataract. operation.. 38.2. |
649 | Case 38 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 38.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of docetaxel and cyclophosphamide) +. Post-operative. radiation. therapy. +. Trastuzumab.. 258. Y. Kwon et al.. 571. . . . HR(−) HER2(+) Breast Cancer. 3. Intraductal component: present, intratu. moral/extratumoral (60%) (nuclear grade:. h... |
655 | Case 38 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 254 255 256. 257. 38.3. |
659 | Case 38 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/55 years old, post-menopause.. Self-detected palpable mass lesion on right. breast.. Family history of breast cancer, sister.. Dyslipidemia.. BRCA 1 and 2 mutation: Not detected,. MUTYH. and. RAD50 VUS. (variant. of. uncertain).. 38.2. |
650 | Case 38 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 38.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and cyclophosphamide + #4. cycles of docetaxel) + Operation + Post-. operative radiation therapy.. Operation. . 285. 286. Pathology Report. No residual tumor with stromal degeneration. . 1. Post-chemotherapy status.. . 2. Lymph... |
656 | Case 38 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 277 278 279. 280. . . . . E. S. Lee et al.. 713. . After Neoadjuvant. Chemotherapy. 281 282 283. 284. 38.3. |
660 | Case 38 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/52 years old, post-menopause.. Self-detected palpable mass lesion on right. breast.. No family history.. s/p bilateral salpingo-oophorectomy.. BRCA 1 mutation carrier.. 38.2. |
651 | Case 38 | Courses of Treatment | Local Recurrence | 38.1. . Courses of Treatment. Right breast IDC→ Operation → Adjuvant ther. apy → Right breast DCIS.. Primary Treatment. Operation. Jun. 2012 Right breast conserving surgery, senti. nel lymph node biopsy (outside).. Pathology Report. Invasive Ductal Carcinoma. . 1. Size of tumor: 0.9 cm (pT1b).. . 2. Lymph nodes: n... |
661 | Case 38 | Patient History | Local Recurrence | Patient History and Progress. Female/47 years old, pre-menopause.. Screen detected mass lesion on right breast 12. o’clock direction.. Outside result of Lumpectomy: Invasive duc. tal carcinoma.. No family history.. Y. Kim et al.. 823. 38.2. |
652 | Case 38 | Courses of Treatment | Metastatic Breast Cancer | Courses of Treatment. Both breasts cancer → Operation → Adjuvant. therapy → Liver metastasis.. Primary Treatment. See Figs. 119 and 120.. Operation. Dec. 2008 Bilateral breast conserving surgery,. axillary lymph node dissection.. Pathology:. Right breast> Invasive ductal carcinoma, stage. pT2N2a, size of tumor: 4.5 cm,... |
662 | Case 38 | Patient History | Metastatic Breast Cancer | |
663 | Case 39 | Courses of Treatment | Carcinoma In Situ | 39.1. . Courses of Treatment. Operation + Tamoxifen 20 mg/day for 6 months.. Operation. 184. 185. Pathology Report. Lobular carcinoma in situ. . 1. Size of tumor: 2.0 cm.. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. E. S. Lee et al.. 137. . 4. Architectural pattern: solid.. . 5. Skin: no involvement of tumo... |
667 | Case 39 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 182. 183. 39.3. |
669 | Case 39 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/47 years old, pre-menopause.. Screen detected mass lesion on right breast 12. o’clock direction.. Outside result of biopsy: lobular carcinoma in. situ.. No family history.. Hypertension.. 39.2. |
664 | Case 39 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation. +. Adjuvant. chemotherapy. (#4 cycles of docetaxel & cyclophospha. mide) + Tamoxifen 20 mg/day.. Operation. Right nipple–areolar complex sparing mastec. tomy with immediate implant reconstruction, left. breast mass excision (Figs. 220, 221 and 222).. Pathology Report. [Right]. Invasi... |
668 | Case 39 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 216, 217, 218 and 219.. 39.3. |
670 | Case 39 | Patient History | HR(+) HER2(-) Breast Cancer | No comorbidities.. 39.2. |
665 | Case 39 | Courses of Treatment | Local Recurrence | 39.1. . Courses of Treatment. Left breast IDC→ Operation → Adjuvant ther. apy → Left breast recurrence (IDC).. Primary Treatment. 258 259 260. 261. Operation. 262. Pathology Report. Invasive Ductal Carcinoma. 1. Size of invasive tumor: 3 cm (pT2).. 2. Size of intraductal component: 4.5 cm.. 3. Histologic grade: 1/... |
671 | Case 39 | Patient History | Local Recurrence | Patient History and Progress. Female/42 years old, post-menopause.. Bloody discharge from left nipple.. No family history.. 39.2. |
666 | Case 39 | Courses of Treatment | Metastatic Breast Cancer | Courses of Treatment. Right breast cancer → Neoadjuvant chemother. apy → Operation → Adjuvant therapy → Left. breast and lung metastasis.. Primary Treatment. Estrogen. receptor. Negative(0/7). 0. 0. Progesterone. receptor. Negative(0/7). 0. 0. C-erbB2. Equivocal (2+). Ki-67. Positive in. 10% of tumor. cells. SISH. Neg... |
672 | Case 39 | Patient History | Metastatic Breast Cancer | Patient History and Progress. Female/51 years old, peri-menopause.. No family history.. BRCA 1 & 2 mutation: Not detected.. Hepatitis B virus carrier, hypertension.. 39.2. |
673 | Case 4 | Courses of Treatment | Benign and Proliferative | 4.1. . Courses of Treatment. → 2021-12-14 Excision, Lt.. Benign and Proliferative Case Series. 22. . 4.3.1. . Pathology Report. Diagnosis. • Breast, left, excision:. –. – Intraductal papilloma.. 5. |
681 | Case 4 | Important Radiologic | Benign and Proliferative | Important Radiologic. Findings. 6. 4.3. |
687 | Case 4 | Patient History | Benign and Proliferative | Patient History and Progress. Female/60 years old, post-menopause.. Screen detected mass lesion on left breast. 12 o’clock direction.. Family history of pancreatic cancer, mother.. Hypertension, dyslipidemia (taking medication).. 4.2. |
674 | Case 4 | Courses of Treatment | Carcinoma In Situ | 4.1. . Courses of Treatment. Operation + Postoperative radiation therapy (left. side) + Tamoxifen 20 mg/day for 5 years.. 4.3.1. . Operation. 19. 20. 4.3.2. . Pathology Report. Right.. <First operation>. Lobular carcinoma in situ. . 1. Size of tumor: 0.2 cm.. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4.... |
682 | Case 4 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 15 16 17. 18. 4.3. |
688 | Case 4 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/46 years old, pre-menopause.. Self-detected palpable mass on right breast 8. and 9 o’clock direction.. No family history.. No comorbidities.. BRCA 1 and 2: No detected mutation,. RAD51C VUS (variant of uncertain).. 4.2. |
675 | Case 4 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 4.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of doxorubicin and cyclophospha. mide). +. Post-operative. radiation. ther. apy + Letrozole 2.5 mg/day.. 23. 4.3.1. . Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 0.6 cm (pT1b).. 2. Histologic grade: 3/3 (tubule formati... |
683 | Case 4 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 19 20 21. 22. 4.3. |
689 | Case 4 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/56 years old, post-menopause.. Screen detected mass lesion on right breast 12. o’clock direction.. No family history.. S/P Thyroid radiofrequency ablation.. 4.2. |
676 | Case 4 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | high, necrosis: present, architectural pattern:. solid/comedo, extensive intraductal compo. nent: absent).. 4. Skin: no involvement of tumor.. 5. Surgical margins:. . (a) superior margin: 10 mm,. . (b) inferior margin: (see note),. . (c) medial margin: 10 mm,. . (d) lateral margin: 15 mm,. . (e) deep margin: 2 ... |
684 | Case 4 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 15, 16, 17 and 18.. HR(+) HER2(−) Breast Cancer |
690 | Case 4 | Patient History | HR(+) HER2(-) Breast Cancer | Dyslipidemia.. 4.2. |
677 | Case 4 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 4.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab and. pertuzumab) + Operation + Post-operative radia. tion therapy.. 4.4.1. . Operation. 35. 4.4.2. . Pathology Report. . 1. No residual tumor with stromal fibrosis.. . (a) Post-chemotherapy status.. . (b... |
685 | Case 4 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 27 28 29. 30. . Y. Kwon et al.. 443. . . . F. ig. 30. 34. . . . . . . Y. Kwon et al.. 445. 4.4. |
691 | Case 4 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/58 years old, post-menopause.. Self-detected mass lesion on left breast 3:30. o’clock direction.. No family history.. No comorbidities.. 4.2. |
678 | Case 4 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 4.1. . Courses of Treatment. Operation + adjuvant chemotherapy (#4 cycles. of docetaxel and cyclophosphamide) + Post-. operative radiation therapy.. 4.3.1. . Operation. 26. 4.3.2. . Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 1.5 cm (pT1c).. 2. Histologic grade: 3/3 (tubule formation: 2/3,. n... |
686 | Case 4 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 22 23 24. 25. HR(−) HER2(−) Breast Cancer. 586. . . . E. S. Lee et al.. 587. . 4.3. |
692 | Case 4 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/52 years old, post-menopause.. Self-detected palpable mass lesion on left. breast 1–2 o’clock direction.. No family history.. Hyperthyroidism.. 4.2. |
679 | Case 4 | Courses of Treatment | Local Recurrence | 4.1. . Courses of Treatment. Left breast Invasive cribriform carcinoma →. Operation → Adjuvant therapy → Left chest. wall recurrence (IDC).. 4.2.1. . Primary Treatment. 22 23. 24. Operation. . 25. 26. Pathology Report. Invasive Cribriform Carcinoma. 1. Size of invasive component: 1.5 cm and. 0.5 cm (pT1c).. 2. Si... |
693 | Case 4 | Patient History | Local Recurrence | Patient History and Progress. Female/41 years old, pre-menopause.. Screen detected mass lesion on left breast 1. and 2 o’clock direction.. Outside result of biopsy: Ductal carcinoma in. situ.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 4.2. |
680 | Case 4 | Courses of Treatment | Metastatic Breast Cancer | Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Left breast and pleural effusion. recurrence.. 4.2.1. . Primary Treatment. Operation. Oct. 2008 Right breast conserving surgery, axil. lary lymph node dissection.. Pathology: Invasive ductal carcinoma, stage. T1(m)N1 (2/25).. Size of tumor: 1... |
694 | Case 4 | Patient History | Metastatic Breast Cancer | BRCA 1 mutation: detected.. s/p Appendectomy, s/p myomectomy.. 4.2. |
695 | Case 40 | Courses of Treatment | Carcinoma In Situ | 40.1. . Courses of Treatment:. Operation. Operation. 189. 190. Pathology Report. Lobular carcinoma in situ. . 1. Post-stereotactic excision status.. . 2. Size of tumor: 1.0 cm, residual.. . 3. Nuclear grade: low.. E. S. Lee et al.. 139. . 4. Necrosis: absent.. . 5. Architectural pattern: solid.. . 6. Skin: no in... |
698 | Case 40 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 186 187. 188. 40.3. |
699 | Case 40 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/47 years old, post-menopause.. Screen detected mass and microcalcification. on right breast 10 o’clock direction.. No family history.. No comorbidities.. 40.2. |
696 | Case 40 | Courses of Treatment | Local Recurrence | 40.1. . Courses of Treatment. Right breast DCIS→ Operation → Right breast. recurrence (microinvasive ductal carcinoma).. Primary Treatment. 266. Local Recurrence. 828. . . Operation. 267. Pathology Report. Ductal Carcinoma In Situ. . 1. Size of tumor: 0.3 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.... |
700 | Case 40 | Patient History | Local Recurrence | Patient History and Progress. Female/60 years old, post-menopause.. Screen detected mass lesion on right breast 12. o’clock and 9 o’clock direction.. Outside result of biopsy: right breast 12. o’clock, Atypical ductal hyperplasia.. Right breast 9:30 o’clock, Fibrocystic change.. Family history of breast cancer, older s... |
697 | Case 40 | Courses of Treatment | Metastatic Breast Cancer | Courses of Treatment. Right breast cancer → Neoadjuvant chemother. apy → Operation → Adjuvant therapy → Lung. metastasis.. Primary Treatment. 3. >2/3. Progesterone. receptor. Strong (8/8). 3. >2/3. C-erbB2. Negative (0). Ki-67. Positive in. 76% of tumor. cells. Neoadjuvant Chemotherapy. Neoadjuvant chemotherapy #8 cyc... |
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