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404 | Case 26 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 147 148 149 150 151. 152. . S. Park et al.. 387. 26.3. |
410 | Case 26 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/61 years old, post-menopause.. Self-detected palpable mass lesion on right. breast 11 o’clock direction.. No family history.. S/P. Tuberculosis,. diabetes. mellitus,. dyslipidemia.. 26.2. |
397 | Case 26 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | 26.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4 cycles. of doxorubicin & cyclophosphamide) + Post-. operative radiation therapy + Tamoxifen. 20 mg/day.. Operation. Left breast conserving surgery, sentinel lymph. 4. Skin: no involvement of tumor.. 5. Surgical margins:. . (a) superior margin: 25 m... |
405 | Case 26 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 145, 146, 147 and 148.. 26.3. |
411 | Case 26 | Patient History | HR(+) HER2(-) Breast Cancer | Patient History and Progress. Female/48 years old, pre-menopause.. Screen detected mass lesion on left breast 1. o’clock direction.. Family history of breast cancer, maternal aunt.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 26.2. |
398 | Case 26 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 26.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4 cycles. of doxorubicin + cyclophosphamide) + Post-. operative radiation therapy + Trastuzumab.. Operation. 184. Pathology Report. Invasive Ductal Carcinoma with medullary. pattern. 1. Size of tumor: 1.5 cm (pT1c).. 2. Histologic grade: 3/3 (tub... |
406 | Case 26 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 181 182. 183. Y. Kwon et al.. 529. . . . 26.3. |
412 | Case 26 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/49 years old, pre-menopause.. Self-detected palpable mass lesion on right. breast 1 o’clock direction.. No family history.. No comorbidities.. 26.2. |
399 | Case 26 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 26.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and cyclophosphamide + #3. cycles of docetaxel + Trastuzumab) + Operati. on + Adjuvant capecitabine + Trastuzumab.. Operation. 193 194. 195. Pathology Report. <Right>. No residual tumor with stromal fibrosis. . 1. Post-chemotherapy s... |
407 | Case 26 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic Findings. 186 187. 188. Breast, right, needle biopsy: Invasive ductal car. cinoma, histologic grade 3 with medullary pattern.. Result. Intensity Positive %. Estrogen. receptor. Negative (0/8). 0. 0. Progesterone. receptor. Negative (0/8). 0. 0. C-erbB2. Negative (1+). Ki-67. Positive in 51%. of tu... |
413 | Case 26 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/53 years old, post-menopause.. Self-detected mass lesion on right breast.. Family history of breast cancer, grandmother.. Family history of ovarian cancer, sister.. S/P appendectomy, s/p bilateral salpingo-. oophorectomy, s/p left shoulder operation.. BRCA 1 mutation carrier.. 26.2... |
400 | Case 26 | Courses of Treatment | Local Recurrence | 26.1. . Courses of Treatment. Right breast DCIS→ Operation → Adjuvant. therapy → Right breast recurrence (IDC).. Primary Treatment. 170. 171. Local Recurrence. 786. a. b. . . Operation. 172. Pathology Report. Ductal Carcinoma In Situ. . 1. Post-excisional biopsy status.. . 2. Size of tumor: 2.0 cm, residual.. . 3. ... |
414 | Case 26 | Patient History | Local Recurrence | Patient History and Progress. Female/40 years old, post-menopause.. Bloody nipple discharge from right breast.. Outside result of biopsy: Ductal carcinoma in. situ.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 26.2. |
401 | Case 26 | Courses of Treatment | Metastatic Breast Cancer | 26.1. . Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Stomach and bone metastasis.. Primary Treatment. receptor. Strong (8/8). 3. >2/3. C-erbB2. Negative (1+). Ki-67. Positive in. 29% of tumor. cells. Left> Invasive lobular carcinoma, stage. pT1c(m)N1mi.. Size of tumor: up to 1.5 cm, mult... |
415 | Case 26 | Patient History | Metastatic Breast Cancer | Patient History and Progress. Female/54 years old, post-menopause.. No family history.. S/p cholecystectomy, s/p total gastrectomy (gas. tric cancer), s/p bilateral salpingo-oophorectomy.. 26.2. |
416 | Case 27 | Courses of Treatment | Benign and Proliferative | 27.1. . Courses of Treatment. →2021-06-07 excision, Rt.. Pathology Report. Diagnosis. • Breast, right, excision:. –. – Intraductal papilloma with usual ductal. hyperplasia.. . C. W. Lee et al.. 51. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023. E. S. Lee (ed.), A Practical Guide ... |
424 | Case 27 | Important Radiologic | Benign and Proliferative | Important Radiologic. Findings. 53. 27.3. |
430 | Case 27 | Patient History | Benign and Proliferative | Patient History and Progress. Female/41 years old, pre-menopause.. Screen detected mass lesion on right breast 4. o’clock direction.. Outside result of biopsy: Papillary neoplasm.. No family history.. No comorbidities.. 27.2. |
417 | Case 27 | Courses of Treatment | Carcinoma In Situ | 27.1. . Courses of Treatment. Operation + Tamoxifen 20 mg/day for 5 years.. Operation. 126. 127. Pathology Report. Lobular carcinoma in situ, pathological TN. category (AJCC 2017): pTis. . 1. Size of tumor: 1.5 cm(pTis).. . 2. Nuclear grade: low.. Carcinoma In Situ. 113. . 3. Necrosis: absent.. . 4. Architectural ... |
425 | Case 27 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 123 124. 125. 27.3. |
431 | Case 27 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/50 years old, pre-menopause.. Screen detected mass lesion on left breast. 2 o’clock direction.. Outside result of mammotome biopsy:. Lobular carcinoma in situ.. No family history.. 27.2. |
418 | Case 27 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 27.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab. and pertuzumab) + Operation + Post-. operative. radiation. ther. apy + Trastuzumab + Tamoxifen 20 mg/day.. . 160. 161. Pathology Report. [Right].. . 1. Ductal carcinoma in situ involving sclerosing.... |
426 | Case 27 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 155 156 157 158. 159. . S. Park et al.. 391. . . 27.3. |
432 | Case 27 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/52 years old, peri-menopause.. Self-detected palpable mass lesion on left. breast 11 o’clock direction.. Family history of breast cancer, cousin. (maternal).. s/p Ovarian cyst excision.. BRCA 1 and 2 mutation: Not detected, NBN. VUS (variant of uncertain).. 27.2. |
419 | Case 27 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | 27.1. . ductal component: present).. 4. Surgical margins:. . (a) superior margin: positive for ductal car. cinoma in situ (Fro 1) (see note 1).. . (b) inferior margin: 25 mm.. . (c) medial margin: (see note 2).. . (d) lateral margin: 15 mm.. . (e) deep margin: <1 mm from invasive duc. tal carcinoma (slide 7)..... |
427 | Case 27 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 150, 151, 152 and 153.. Y. Kim et al. |
433 | Case 27 | Patient History | HR(+) HER2(-) Breast Cancer | Patient History and Progress. Female/60 years old, post-menopause.. Screen detected mass lesion on left breast 10. o’clock direction.. No family history.. No comorbidities.. 27.2. |
420 | Case 27 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 27.1. . Courses of Treatment. Operation + Post-operative radiation ther. apy + Adjuvant paclitaxel and trastuzumab.. Operation. 188. Pathology Report. . 1. Invasive ductal carcinoma with medullary. pattern.. . (a) Size of tumor: 0.8 cm (pT1b).. . (b) Histologic grade: 3/3 (tubule formation:. 3/3, nuclear pleomor... |
428 | Case 27 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 185 186. 187. . . . HR(−) HER2(+) Breast Cancer. 532. 27.3. |
434 | Case 27 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/69 years old, post-menopause.. Screen detected mass lesion on right breast 9. o’clock direction.. Family history of breast cancer, sister.. Hypertension, dyslipidemia.. BRCA 1 and 2 mutation: Not examination.. 27.2. |
421 | Case 27 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 27.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and cyclophosphamide + #4. cycles of docetaxel) + Operation + Post-. operative radiation therapy + Adjuvant. capecitabine.. Operation. 203. Pathology Report. Invasive Ductal Carcinoma. 1. Post-chemotherapy status.. 2. Size of ... |
429 | Case 27 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 196 197 198. 199. . HR(−) HER2(−) Breast Cancer. 672. . . . . E. S. Lee et al.. 673. . After Neoadjuvant. Chemotherapy. 200 201. 202. 27.3. |
435 | Case 27 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/36 years old, pre-menopause.. Self-detected palpable mass lesion on left. breast.. Family history of breast cancer, aunt. (maternal).. No comorbidities.. BRCA 1 and 2 mutation: Not detected,. RAD50 VUS (variant of uncertain).. 27.2. |
422 | Case 27 | Courses of Treatment | Local Recurrence | 27.1. . Courses of Treatment. Right breast tubular carcinoma → Operation. → Adjuvant therapy → Left breast recurrence. (IDC).. Primary Treatment. 176 177 178. 179. Operation. . 180. Pathology Report. Tubular Carcinoma. 1. Size of tumor: 1.5 cm (pT1c).. 2. Histologic grade: 1/3 (tubule formation: 1/3,. nuclear pleom... |
436 | Case 27 | Patient History | Local Recurrence | Patient History and Progress. Female/57 years old, post-menopause.. Screen detected mass lesion on right breast 1. o’clock direction.. Outside result of biopsy: Invasive ductal. carcinoma.. Family history of breast cancer, younger. sister.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 27.2. |
423 | Case 27 | Courses of Treatment | Metastatic Breast Cancer | Courses of Treatment. Left breast cancer → Operation → Adjuvant. therapy. →. Right. shoulder. soft. tissue. metastasis.. Primary Treatment. Estrogen. receptor. Strong (6/7). 3. 1/3–2/3. Progesterone. receptor. Weak (2/7). 1. <10%. C-erbB2. Equivocal. (2+). Ki-67. Positive in. 15% of tumor. cells. FISH. Negative. Adjuva... |
437 | Case 27 | Patient History | Metastatic Breast Cancer | 27.2. |
438 | Case 28 | Courses of Treatment | Carcinoma In Situ | 28.1. . Courses of Treatment. Operation + Tamoxifen 20 mg/day for 5 years.. Operation. 131. 132. Pathology Report. Lobular carcinoma in situ, pathological TN. category (AJCC 2017): pTis. . 1. Size of tumor: 0.7 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: solid.. . 5. ... |
445 | Case 28 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 128 129. 130. 28.3. |
450 | Case 28 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/50 years old, pre-menopause.. Screen detected microcalcification on upper. outer portion of right breast.. Outside result of stereotactic excisional. biopsy: Lobular carcinoma in situ.. No family history.. No comorbidities.. 28.2. |
439 | Case 28 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 28.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#3. cycles of doxorubicin and cyclophospha. mide). +. Post-operative. radiation. ther. apy + Trastuzumab + Tamoxifen 20 mg/day.. 166. Pathology Report. . 1. Invasive Ductal Carcinoma.. . (a) Size of invasive component: 1.6 cm. (pT1c).. . (b) Size... |
446 | Case 28 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 162 163 164. 165. 28.3. |
451 | Case 28 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/47 years old, pre-menopause.. Self-detected palpable mass lesion on right. breast 6 o’clock direction.. No family history.. Hepatitis B carrier.. 28.2. |
440 | Case 28 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | . Courses of Treatment. Operation + Post-operative radiation ther. apy + Letrozole 2.5 mg/day with palbociclib. 100 mg/day.. Operation. Right breast conserving surgery, sentinel lymph. ponent: absent).. 4. Skin: no involvement of tumor.. HR(+) HER2(−) Breast Cancer. . (e) deep margin: 5 mm.. . (f) superficial... |
447 | Case 28 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 155, 156, 157 and 158.. 28.3. |
452 | Case 28 | Patient History | HR(+) HER2(-) Breast Cancer | Patient History and Progress. Female/72 years old, post-menopause.. Screen detected mass lesion on right breast 8. o’clock direction.. No family history.. S/p cholecystectomy, hypertension.. 28.2. |
441 | Case 28 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 28.1. . docetaxel and carboplatin and trastuzumab and. pertuzumab) + Operation + Post-operative radia. tion therapy + Trastuzumab and pertuzumab.. Operation. 196. Pathology Report. Ductal Carcinoma In Situ. 1. Post-chemotherapy status.. 2. Size of tumor: 0.2 cm (ypTis).. 3. Nuclear grade: high.. 4. Necrosis: abse... |
448 | Case 28 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 189 190 191. 192. . HR(−) HER2(+) Breast Cancer. 534. . . . F. ig. 192. Chemotherapy. 193 194. 195. . . |
453 | Case 28 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/61 years old, post-menopause.. Screen detected mass lesion on right breast 9. o’clock direction.. No family history.. Hypertension.. 28.2. |
442 | Case 28 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 28.1. . Courses of Treatment. Operation + Post-operative radiation therapy. (Adjuvant chemotherapy refuse).. Operation. 207. Pathology Report. Malignant Adenomyoepithelioma (Epithelial-. Myoepithelial Carcinoma). 1. Size of tumor: 2.0 cm (pT1c).. HR(−) HER2(−) Breast Cancer. 676. . . . . E. S. Lee et al.. 677. . 2.... |
449 | Case 28 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic Findings. 204 205. 206. 28.3. |
454 | Case 28 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/57 years old, post-menopause.. Self-detected palpable mass lesion on right.. No family history.. S/P. right. neck. excision. (due. to. lymphadenitis).. 28.2. |
443 | Case 28 | Courses of Treatment | Local Recurrence | 28.1. . Courses of Treatment. Left breast DCIS → Operation → Adjuvant. therapy → Left breast recurrence (microinva. sive ductal carcinoma).. Primary Treatment. 185 186 187. 188. Local Recurrence. 792. . . . . Operation. . 189. Pathology Report. Ductal carcinoma in situ. 1. Post mammotome biopsy status.. 2. Size o... |
455 | Case 28 | Patient History | Local Recurrence | Patient History and Progress. Female/50 years old, pre-menopause.. Screen detected mass lesion on left breast 2. o’clock direction.. Outside result of mammotome excision:. Ductal carcinoma in situ.. No family history.. No comorbidities.. 28.2. |
444 | Case 28 | Courses of Treatment | Metastatic Breast Cancer | 28.1. . Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy. →. Right. shoulder. soft. tissue. metastasis.. Primary Treatment. receptor. Strong (7/8). 2. >2/3. Progesterone. receptor. Strong (7/8). 2. >2/3. C-erbB2. Negative (1+). Ki-67. Positive in 7%. of tumor cells. Adjuvant Therapy. Post-oper... |
456 | Case 28 | Patient History | Metastatic Breast Cancer | Patient History and Progress. Female/51 years old, post-menopause.. No family history.. BRCA 1 & 2 mutation: Not detected, ATM. VUS (variant of uncertain).. Metastatic Breast Cancer. 908. 28.2. |
457 | Case 29 | Courses of Treatment | Carcinoma In Situ | 29.1. . Courses of Treatment. Operation + Adjuvant chemotherapy #4 cycles. (Doxorubicin and Cyclophosphamide) + Postope. rative radiation therapy (both) + Letrozole. 2.5 mg/day for 5 years.. Operation. 136. 137. Pathology Report. Right.. Lobular carcinoma in situ, pathological TN. category (AJCC 2017): pTis. . 1. ... |
464 | Case 29 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 133 134. 135. 29.3. |
469 | Case 29 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/50 years old, post-menopause.. Screen detected mass lesion on left breast. 2 o’clock direction.. Outside result of biopsy: Left breast 2 o’clock,. invasive ductal carcinoma.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected, MSH6. VUS (variant of uncertain)... |
458 | Case 29 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 29.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of docetaxel and cyclophosphamide and. trastuzumab) + Post-operative radiation ther. apy + Trastuzumab + Letrozole 2.5 mg/day.. 171. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 2.1 cm (pT2).. 2. Histologic grade: 2/3 (t... |
465 | Case 29 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 167 168 169. 29.3. |
470 | Case 29 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/80 years old, post-menopause.. Self-detected mass lesion on right breast 8. o’clock direction.. No family history.. Hypertension, dyslipidemia, s/p tympano. plasty.. 29.2. |
459 | Case 29 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation + Post-operative radiation ther. apy + Letrozole 2.5 mg/day.. Y. Kim et al.. 265. Operation. Left breast conserving surgery, sentinel lymph. 4. Skin: no involvement of tumor.. 5. Surgical margins:. . (a) superior margin: 20 mm.. . (b) inferior margin: 10 mm.. . (c) medial margin:... |
466 | Case 29 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 160, 161, 162 and 163.. 29.3. |
471 | Case 29 | Patient History | HR(+) HER2(-) Breast Cancer | S/P hysterectomy, hypertension, s/p left cere. bral infarction, s/p transient ischemic attack.. 29.2. |
460 | Case 29 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 29.1. . Courses of Treatment. Operation (adjuvant chemotherapy refuse).. Operation. 200. 201. Pathology Report. Microinvasive Ductal Carcinoma. 1. Size of invasive component: <0.1 cm (pT1mi).. 2. Size of intraductal component: 5.0 cm.. 3. Histologic grade: not applicable.. 4. Intraductal component: present, intrat... |
467 | Case 29 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 197 198. 199. . . . . HR(−) HER2(+) Breast Cancer. 538. 29.3. |
472 | Case 29 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/39 years old, pre-menopause.. Self-detected palpable mass lesion on upper. outer portion of left breast.. No family history.. S/P Left salpingo-oophorectomy.. BRCA 1 and 2 mutation: Not detected.. 29.2. |
461 | Case 29 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 29.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of doxo. rubicin and cyclophosphamide + #4 cycles of. docetaxel) + Operation + Post-operative radia. tion therapy + Adjuvant capecitabine.. Operation. 215. Pathology Report. Microinvasive Ductal Carcinoma. 1. Post-chemotherapy status.. 2. Size of tu... |
468 | Case 29 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic Findings. 208 209 210. 211. . E. S. Lee et al.. 679. . . . . HR(−) HER2(−) Breast Cancer. 680. . After Neoadjuvant. Chemotherapy. 212 213. 214. 29.3. |
473 | Case 29 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/27 years old, pre-menopause.. Self-detected mass lesion on left breast.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. HR(−) HER2(−) Breast Cancer. 678. 29.2. |
462 | Case 29 | Courses of Treatment | Local Recurrence | 29.1. . Courses of Treatment. Left breast IDC→ Operation → Adjuvant ther. apy → Left breast recurrence (IDC).. Primary Treatment. 194 195 196. 197. Operation. . 198. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 3.0 cm (pT2).. . . . . Local Recurrence. 796. 2. Histologic grade: 2/3 (tubule format... |
474 | Case 29 | Patient History | Local Recurrence | Patient History and Progress. Female/46 years old, pre-menopause.. Screen detected mass lesion on left breast 7:30. o’clock direction.. Outside result of biopsy: (1) Invasive ductal. carcinoma, (2) Atypical ductal hyperplasia.. Family history of breast cancer, mother.. Asthma.. BRCA 1 VUS (variant of uncertain).. 29.2.... |
463 | Case 29 | Courses of Treatment | Metastatic Breast Cancer | Courses of Treatment. Right breast cancer → Neoadjuvant chemother. apy → Operation → Adjuvant therapy → Lung. metastasis.. Primary Treatment. receptor. Strong. (6/7). 3. 1/3–2/3. Progesterone. receptor. Strong. (6/7). 3. 1/3–2/3. C-erbB2. Negative. (1+). Ki-67. N.A. Clinical stage: cT3N1M0.. Operation. Oct. 2007 Right... |
475 | Case 29 | Patient History | Metastatic Breast Cancer | |
476 | Case 3 | Courses of Treatment | Benign and Proliferative | 3.1. . Courses of Treatment. → 2021-12-10 Excision, Rt.. C. W. Lee et al.. 21. . . . . 3.3.1. . Pathology Report. Diagnosis. • Breast, right, excision:. –. – Intraductal papilloma.. 4. |
484 | Case 3 | Important Radiologic | Benign and Proliferative | Important Radiologic. Findings. 4. 5. 3.3. |
490 | Case 3 | Patient History | Benign and Proliferative | Patient History and Progress. Female/72 years old, post-menopause.. Screen detected nodular lesion on right breast. 9 o’clock direction.. No family history.. Hypertension.. 3.2. |
477 | Case 3 | Courses of Treatment | Carcinoma In Situ | Courses of Treatment. Operation + Tamoxifen 20 mg/day for 5 years.. 3.3.1. . Operation. 13. 14. 3.3.2. . Pathology Report. <First operation>. Lobular carcinoma in situ. . 1. Size of tumor: 0.3 cm.. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: solid.. . 5. Surgical margins:. . (a)... |
485 | Case 3 | Important Radiologic | Carcinoma In Situ | 3.1. . Important Radiologic. Findings. 11. 12. 3.3. |
491 | Case 3 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/41 years old, pre-menopause.. Screen detected microcalcifications on right. breast upper outer.. Outside result of biopsy: Right 10 o’clock. 1.. Usual ductal hyperplasia, 2. duct ectasia.. No family history.. S/P Hallux valgus operation.. 3.2. |
478 | Case 3 | Courses of Treatment | HR(+) HER2(+) Breast Cancer | 3.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of doxorubicin and cyclophospha. mide). +. Post-operative. radiation. ther. apy + Trastuzumab + Letrozole 2.5 mg/day.. . . S. Park et al.. 307. . 18. 3.3.1. . Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 1.8 cm (pT1c).. ... |
486 | Case 3 | Important Radiologic | HR(+) HER2(+) Breast Cancer | Important Radiologic. Findings. 13 14 15 16. 17. 3.3. |
492 | Case 3 | Patient History | HR(+) HER2(+) Breast Cancer | Patient History and Progress. Female/58 years old, post-menopause.. Screen detected mass lesion on right breast 7. o’clock direction.. No family history.. Dyslipidemia.. 3.2. |
479 | Case 3 | Courses of Treatment | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation + Post-operative radiation ther. apy + Letrozole 2.5 mg/day.. Y. Kim et al.. moral/extratumoral (5%) (nuclear grade:. low, necrosis: absent, architectural pattern:. cribriform, extensive intraductal component:. absent).. 4. Skin: no involvement of tumor.. 5. Surgical margins:. . (a)... |
487 | Case 3 | Important Radiologic | HR(+) HER2(-) Breast Cancer | Important Radiologic. Findings. See Figs. 10, 11, 12 and 13.. 3.3. |
493 | Case 3 | Patient History | HR(+) HER2(-) Breast Cancer | No family history.. L-spine disc herniation.. 3.2. |
480 | Case 3 | Courses of Treatment | HR(−) HER2(+) Breast Cancer | 3.1. . Courses of Treatment. Palliative chemotherapy (#7 cycles of docetaxel. and. trastuzumab. and. pertuzumab). +. Operation. +. Post-operative. radiation. ther. apy + Palliative trastuzumab and pertuzumab.. 3.4.1. . Operation. 26. 3.4.2. . Pathology Report. Ductal Carcinoma In Situ. 1. Post-chemotherapy status.... |
488 | Case 3 | Important Radiologic | HR(−) HER2(+) Breast Cancer | Important Radiologic. Findings. 18 19 20. 21. . HR(−) HER2(+) Breast Cancer. 438. . . . Y. Kwon et al.. 439. F. i. g. . 21. . . . . . . . 3.3. . After Neoadjuvant. Chemotherapy. 22 23 24. 25. Y. Kwon et al.. 441. 3.4. |
494 | Case 3 | Patient History | HR(−) HER2(+) Breast Cancer | Patient History and Progress. Female/61 years old, post-menopause.. Self-detected nipple retraction on right breast.. Family history of breast cancer, cousin. (maternal).. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 3.2. |
481 | Case 3 | Courses of Treatment | HR(−) HER2(−) Breast Cancer | 3.1. . Courses of Treatment. Operation + operation, Transfer.. 3.3.1. . Operation. 20. 3.3.2. . Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 2.3 cm (pT2).. 2. Histologic grade: 3/3 (tubule formation: 2/3,. nuclear pleomorphism: 3/3, mitotic count:. 3/3, 82/10HPF).. 3. Intraductal component: pres... |
489 | Case 3 | Important Radiologic | HR(−) HER2(−) Breast Cancer | Important Radiologic. Findings. 16 17 18. 19. 3.3. |
495 | Case 3 | Patient History | HR(−) HER2(−) Breast Cancer | Patient History and Progress. Female/41 years old, pre-menopause.. Screen detected mass lesion on left breast 3. o’clock direction.. No family history.. No comorbidities.. 3.2. |
482 | Case 3 | Courses of Treatment | Local Recurrence | 3.1. . Courses of Treatment. Left breast IDC + DCIS → Operation → Left. breast recurrence (DCIS).. 14. 15. 3.2.1. . Operation. 16. 3.2.2. . Pathology Report. Ductal Carcinoma In Situ. . 1. Size of tumor: 1.5 cm.. . 2. Nuclear grade: high.. . 3. Necrosis: present.. . 4. Architectural pattern: solid/comedo.. . 5. ... |
496 | Case 3 | Patient History | Local Recurrence | Patient History and Progress. Female/47 years old, pre-menopause.. Screen detected microcalcification on upper. portion of left breast.. Family history of colon cancer, father.. No comorbidities.. 3.2. |
483 | Case 3 | Courses of Treatment | Metastatic Breast Cancer | Courses of Treatment. Left. breast. cancer. →. Neoadjuvant. Chemotherapy → Operation → Adjuvant therapy. → Bone, lung, and brain metastasis.. 3.2.1. . Primary Treatment. Docetaxel #4).. Operation. Mar. 2018 Left modified radical mastectomy.. Pathology: Invasive ductal carcinoma, stage. ypT2N1.. Size of tumor: 2.7 * 2.... |
497 | Case 3 | Patient History | Metastatic Breast Cancer | |
498 | Case 30 | Courses of Treatment | Carcinoma In Situ | 30.1. . Courses of Treatment. Operation + Postoperative Radiation therapy.. Operation. 142. 143. Pathology Report. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTisN0(sn). . 1. Size of tumor: 2.0 cm (pTis).. . 2. Nuclear grade: high.. . 3. Necrosis: present.. . 4. Architectural pattern: micro... |
505 | Case 30 | Important Radiologic | Carcinoma In Situ | Important Radiologic. Findings. 138 139 140. 141. 30.3. |
510 | Case 30 | Patient History | Carcinoma In Situ | Patient History and Progress. Female/60 years old, post-menopause.. Screen detected mass and microcalcification. on left breast 10 o’clock direction.. Outside result of biopsy: Ductal carcinoma in. situ.. No family history.. Claustrophobia, hypertension.. 30.2. |
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