id stringlengths 40 40 | source stringclasses 9
values | title stringlengths 2 345 | clean_text stringlengths 35 1.63M | raw_text stringlengths 4 1.63M | url stringlengths 4 498 | overview stringlengths 0 10k |
|---|---|---|---|---|---|---|
2a489a14dfb315eedddd8f58535f05cf4320a119 | wikidoc | SDHD | SDHD
Succinate dehydrogenase cytochrome b small subunit, mitochondrial (CybS), also known as succinate dehydrogenase complex subunit D (SDHD), is a protein that in humans is encoded by the SDHD gene. Names previously used for SDHD were PGL and PGL1. Succinate dehydrogenase is an important enzyme in both the citric aci... | SDHD
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS), also known as succinate dehydrogenase complex subunit D (SDHD), is a protein that in humans is encoded by the SDHD gene. Names previously used for SDHD were PGL and PGL1. Succinate dehydrogenase is an important enzyme in both t... | https://www.wikidoc.org/index.php/SDHD | |
1c3f72e65af787842e12209eb1ad11c8ac46260c | wikidoc | SDPR | SDPR
Cavin-2 or Serum deprivation-response protein (SDPR) is a protein that in humans is encoded by the SDPR gene. Cavin-2 is highly expressed in a variety of human endothelial cells.
This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein has... | SDPR
Cavin-2 or Serum deprivation-response protein (SDPR) is a protein that in humans is encoded by the SDPR gene.[1][2][3] Cavin-2 is highly expressed in a variety of human endothelial cells.[4]
This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. Thi... | https://www.wikidoc.org/index.php/SDPR | |
b72cbdafd3df19995d52f848ac728ea4e6d557ad | wikidoc | SELT | SELT
Selenoprotein T, also known as SELT, is a protein that in humans is encoded by the SELT gene.
# Gene
The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necess... | SELT
Selenoprotein T, also known as SELT, is a protein that in humans is encoded by the SELT gene.[1][2][3]
# Gene
The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that... | https://www.wikidoc.org/index.php/SELT | |
17144645b157844de16243b750e74ef62b27bcf8 | wikidoc | SGCG | SGCG
Gamma-sarcoglycan is a protein that in humans is encoded by the SGCG gene. The α to δ-sarcoglycans are expressed predominantly (β) or exclusively (α, γ and δ) in striated muscle. A mutation in any of the sarcoglycan genes may lead to a secondary deficiency of the other sarcoglycan proteins, presumably due to desta... | SGCG
Gamma-sarcoglycan is a protein that in humans is encoded by the SGCG gene.[1][2] The α to δ-sarcoglycans are expressed predominantly (β) or exclusively (α, γ and δ) in striated muscle.[3] A mutation in any of the sarcoglycan genes may lead to a secondary deficiency of the other sarcoglycan proteins, presumably du... | https://www.wikidoc.org/index.php/SGCG | |
93c284d697448496a853f51ab0d9973c45ed03c9 | wikidoc | SGCZ | SGCZ
Sarcoglycan zeta also known as SGCZ is a protein which in humans is encoded by the SGCZ gene.
# Function
The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with... | SGCZ
Sarcoglycan zeta also known as SGCZ is a protein which in humans is encoded by the SGCZ gene.[1]
# Function
The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins ... | https://www.wikidoc.org/index.php/SGCZ | |
762d2ffdd25e031d07dfe14c3a16837ddc51721e | wikidoc | SGEF | SGEF
SGEF (Src homology 3 domain-containing Guanine nucleotide Exchange Factor) is a 97 kDa protein involved in intracellular signalling networks. It functions as a guanine nucleotide exchange factor (GEF) for RhoG, a small G protein of the Rho family.
# Discovery
SGEF was discovered during a screen for androgen-resp... | SGEF
SGEF (Src homology 3 domain-containing Guanine nucleotide Exchange Factor) is a 97 kDa protein involved in intracellular signalling networks. It functions as a guanine nucleotide exchange factor (GEF) for RhoG, a small G protein of the Rho family.[1]
# Discovery
SGEF was discovered during a screen for androgen-... | https://www.wikidoc.org/index.php/SGEF | |
cc1d16e8ebbe460910da71edfca8a73c5596c425 | wikidoc | SGK1 | SGK1
Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene.
SGK1 belongs to a subfamily of serine/threonine kinases that is under acute transcriptional control by several stimuli, including serum and glucocorticoids. The ki... | SGK1
Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene.
SGK1 belongs to a subfamily of serine/threonine kinases that is under acute transcriptional control by several stimuli, including serum and glucocorticoids. The k... | https://www.wikidoc.org/index.php/SGK1 | |
b60f4156520d91446ead01b52c5b333ee4925446 | wikidoc | SGK3 | SGK3
Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the SGK3 gene.
# Function
This gene is a member of the serine/threonine protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral a... | SGK3
Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the SGK3 gene.[1][2][3]
# Function
This gene is a member of the serine/threonine protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in... | https://www.wikidoc.org/index.php/SGK3 | |
4283baa64851b163d4d8b6740a3ce41707fc5836 | wikidoc | SHC1 | SHC1
SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene. SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells.
SCOP classifies the 3D structure as belonging to the SH2 domain family.
# Gene and expression
The gene SHC1 is located on c... | SHC1
SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene.[1] SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells.
SCOP classifies the 3D structure as belonging to the SH2 domain family.
# Gene and expression
The gene SHC1 is located ... | https://www.wikidoc.org/index.php/SHC1 | |
f6605b896037f9d19134af25d63777de7c5c33ef | wikidoc | SIM1 | SIM1
Single-minded homolog 1 also known as class E basic helix-loop-helix protein 14 (bHLHe14) is a protein that in humans is encoded by the SIM1 gene.
# Function
SIM1 and SIM2 genes are homologs of Drosophila melanogaster single-minded (sim), so named because cells in the midline of the sim mutant embryo fail to prop... | SIM1
Single-minded homolog 1 also known as class E basic helix-loop-helix protein 14 (bHLHe14) is a protein that in humans is encoded by the SIM1 gene.[1][2][3]
# Function
SIM1 and SIM2 genes are homologs of Drosophila melanogaster single-minded (sim), so named because cells in the midline of the sim mutant embryo fa... | https://www.wikidoc.org/index.php/SIM1 | |
fd14f64b28194fe4a4ebaa5b0802305842d09b31 | wikidoc | SIM2 | SIM2
Single-minded homolog 2 is a protein that in humans is encoded by the SIM2 gene. It plays a major role in the development of the central nervous system midline as well as the construction of the face and head.
# Function
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene... | SIM2
Single-minded homolog 2 is a protein that in humans is encoded by the SIM2 gene.[1][2] It plays a major role in the development of the central nervous system midline as well as the construction of the face and head.[3]
# Function
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophil... | https://www.wikidoc.org/index.php/SIM2 | |
bbcef20a6347d4a1798d3ce5b989dd0c79f8877a | wikidoc | SIX1 | SIX1
Homeobox protein SIX1 (Sineoculis homeobox homolog 1) is a protein that in humans is encoded by the SIX1 gene.
# Function
The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the developing visual system of the fly. Members of the SIX gene family encode ... | SIX1
Homeobox protein SIX1 (Sineoculis homeobox homolog 1) is a protein that in humans is encoded by the SIX1 gene.[1][2][3]
# Function
The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the developing visual system of the fly. Members of the SIX gene fami... | https://www.wikidoc.org/index.php/SIX1 | |
37f0bafcddc30bf386546a96b7f644fa3351020b | wikidoc | SIX3 | SIX3
Homeobox protein SIX3 is a protein that in humans is encoded by the SIX3 gene.
# Function
The SIX homeobox 3 (SIX3) gene is crucial in embryonic development by providing necessary instructions for the formation of the forebrain and eye development. SIX3 is a transcription factor that binds to specific DNA sequenc... | SIX3
Homeobox protein SIX3 is a protein that in humans is encoded by the SIX3 gene.[1][2][3]
# Function
The SIX homeobox 3 (SIX3) gene is crucial in embryonic development by providing necessary instructions for the formation of the forebrain and eye development. SIX3 is a transcription factor that binds to specific D... | https://www.wikidoc.org/index.php/SIX3 | |
7f6aeef0e5e010f6eb1b5019ea03cb8f753538b0 | wikidoc | SKA2 | SKA2
Spindle and kinetochore-associated protein 2 is a protein that in humans is encoded by the SKA2 gene found in chromosome 17. SKA2 is a part of a spindle and kinetochore associated complex also including SKA1 and SKA3 which is responsible for onset of the anaphase in mitosis by regulating chromosomal segregation.
S... | SKA2
Spindle and kinetochore-associated protein 2 is a protein that in humans is encoded by the SKA2 gene found in chromosome 17. SKA2 is a part of a spindle and kinetochore associated complex also including SKA1 and SKA3 which is responsible for onset of the anaphase in mitosis by regulating chromosomal segregation.[... | https://www.wikidoc.org/index.php/SKA2 | |
0d40080a173418084e2e0f841309f87af9cdfef8 | wikidoc | SKP2 | SKP2
S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene.
# Structure and function
Skp2 contains 424 residues in total with the ~40 amino acid F-box domain lying closer to the N-terminal region at the 94-140 position and the C-terminal region forming a concave surface consisting... | SKP2
S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene.[1][2]
# Structure and function
Skp2 contains 424 residues in total with the ~40 amino acid F-box domain lying closer to the N-terminal region at the 94-140 position and the C-terminal region forming a concave surface con... | https://www.wikidoc.org/index.php/SKP2 | |
ca90ee2707d7e6cbbcf6cb219b41e2a1a530e9f3 | wikidoc | SLBP | SLBP
Histone RNA hairpin-binding protein or stem-loop binding protein (SLBP) is a protein that in humans is encoded by the SLBP gene.
# Species distribution
SLBP has been cloned from humans, C. elegans, D. melanogaster, X. laevis, and sea urchins. The full length human protein has 270 amino acids (31 kDa) with a cen... | SLBP
Histone RNA hairpin-binding protein or stem-loop binding protein (SLBP) is a protein that in humans is encoded by the SLBP gene.[1][2][3]
# Species distribution
SLBP has been cloned from humans, C. elegans, D. melanogaster, X. laevis, and sea urchins. The full length human protein has 270 amino acids (31 kDa) ... | https://www.wikidoc.org/index.php/SLBP | |
da4207ed7a0bd9438a0e677e49791b140ae50cd6 | wikidoc | SLPI | SLPI
Antileukoproteinase, also known as secretory leukocyte protease inhibitor (SLPI), is an enzyme that in humans is encoded by the SLPI gene. SLPI is a highly cationic single-chain protein with eight intramolecular disulfide bonds. It is found in large quantities in bronchial, cervical, and nasal mucosa, saliva, and ... | SLPI
Antileukoproteinase, also known as secretory leukocyte protease inhibitor (SLPI), is an enzyme that in humans is encoded by the SLPI gene.[1][2][3] SLPI is a highly cationic single-chain protein with eight intramolecular disulfide bonds. It is found in large quantities in bronchial, cervical, and nasal mucosa, sa... | https://www.wikidoc.org/index.php/SLPI | |
332b6b7b7600437072f41296273e28e45a71362a | wikidoc | SLUD | SLUD
SLUD (Salivation, Lacrimation, Urination, Defecation ) is a syndrome of pathological effects indicative of massive discharge of the parasympathetic nervous system. Unlikely to occur naturally, SLUD is usually encountered only in cases of drug overdose or exposure to nerve gases. Nerve gases irreversibly inhibit ... | SLUD
Template:Search infobox
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
SLUD (Salivation, Lacrimation, Urination, Defecation [and emesis]) is a syndrome of pathological effects indicative of massive discharge of the parasympathetic nervous system. Unlikely to occur naturally, SLUD is usually encountered only ... | https://www.wikidoc.org/index.php/SLUD | |
8178950a35dd9ec2c9eb3ce4c10ca8993b36839d | wikidoc | SLX4 | SLX4
SLX4 (also known as BTBD12 and FANCP) is a protein involved in DNA repair, where it has important roles in the final steps of homologous recombination. Mutations in the gene are associated with the disease Fanconi anemia.
The version of SLX4 present in humans and other mammals acts as a sort of scaffold upon which... | SLX4
SLX4 (also known as BTBD12 and FANCP) is a protein involved in DNA repair, where it has important roles in the final steps of homologous recombination.[1] Mutations in the gene are associated with the disease Fanconi anemia.[2][3]
The version of SLX4 present in humans and other mammals acts as a sort of scaffold ... | https://www.wikidoc.org/index.php/SLX4 | |
079d7fa061bf7ef265a6ca489e33f8aad17ad57b | wikidoc | SMC3 | SMC3
Structural maintenance of chromosomes protein 3 (SMC-3) is a nuclear protein that in humans is encoded by the SMC3 gene. A post-translated modified form that is excreted is known as basement membrane-associated chondroitin proteoglycan (bamacan).
# Function
This gene belongs to the SMC3 subfamily of SMC proteins.... | SMC3
Structural maintenance of chromosomes protein 3 (SMC-3) is a nuclear protein that in humans is encoded by the SMC3 gene.[1] A post-translated modified form that is excreted is known as basement membrane-associated chondroitin proteoglycan (bamacan).
# Function
This gene belongs to the SMC3 subfamily of SMC prote... | https://www.wikidoc.org/index.php/SMC3 | |
f4cf4c6ad330ec78d74d0ffa6b555666983606ca | wikidoc | SMC5 | SMC5
Structural maintenance of chromosomes protein 5 is a protein encoded by the SMC5 gene in human.
It is involved in the Alternative lengthening of telomeres cancer mechanism.
# Role in recombination and meiosis
Smc5 and Smc6 proteins form a heterodimeric ring-like structure and together with other non-SMC elements ... | SMC5
Structural maintenance of chromosomes protein 5 is a protein encoded by the SMC5 gene in human.[1][2]
It is involved in the Alternative lengthening of telomeres cancer mechanism.[3]
# Role in recombination and meiosis
Smc5 and Smc6 proteins form a heterodimeric ring-like structure and together with other non-SMC... | https://www.wikidoc.org/index.php/SMC5 | |
6165a454e153b0990875160308e483878f6299dc | wikidoc | SMC6 | SMC6
Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene.
It is involved in the Alternative lengthening of telomeres cancer mechanism.
# Role in recombination and meiosis
Smc6 and Smc5 proteins form a heterodimeric ring-like structure and together with other non-SMC ... | SMC6
Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene.[1][2]
It is involved in the Alternative lengthening of telomeres cancer mechanism.[3]
# Role in recombination and meiosis
Smc6 and Smc5 proteins form a heterodimeric ring-like structure and together with othe... | https://www.wikidoc.org/index.php/SMC6 | |
fb33cddd8d5882323f72a9b8ec8e00b037a8f046 | wikidoc | SMG1 | SMG1
Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene. SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase protein family.
# Function
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein... | SMG1
Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene.[1][2][3][4] SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase protein family.
# Function
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex... | https://www.wikidoc.org/index.php/SMG1 | |
b912b2c3311f6bdc1376e321b2019f7b6f69fd6e | wikidoc | SMG6 | SMG6
Telomerase-binding protein EST1A is an enzyme that in humans is encoded by the SMG6 gene on chromosome 17. It is ubiquitously expressed in many tissues and cell types. The C-terminus of the EST1A protein contains a PilT N-terminus (PIN) domain. This structure for this domain has been determined by X-ray crystallog... | SMG6
Telomerase-binding protein EST1A is an enzyme that in humans is encoded by the SMG6 gene on chromosome 17.[1][2][3] It is ubiquitously expressed in many tissues and cell types.[4] The C-terminus of the EST1A protein contains a PilT N-terminus (PIN) domain. This structure for this domain has been determined by X-r... | https://www.wikidoc.org/index.php/SMG6 | |
ebf517ac471a73b18e1bfa1f33582412352ada9f | wikidoc | SMN1 | SMN1
Survival of motor neuron 1 (SMN1), also known as component of gems 1 or GEMIN1, is a gene that encodes the SMN protein in humans.
# Gene
SMN1 is the telomeric copy of the gene encoding the SMN protein; the centromeric copy is termed SMN2. SMN1 and SMN2 are part of a 500 kb inverted duplication on chromosome 5q13.... | SMN1
Survival of motor neuron 1 (SMN1), also known as component of gems 1 or GEMIN1, is a gene that encodes the SMN protein in humans.[1][2]
# Gene
SMN1 is the telomeric copy of the gene encoding the SMN protein; the centromeric copy is termed SMN2. SMN1 and SMN2 are part of a 500 kb inverted duplication on chromosom... | https://www.wikidoc.org/index.php/SMN1 | |
bb43e3413b974519316fd86509a9718592b4a44a | wikidoc | SMN2 | SMN2
Survival of motor neuron 2 (SMN2) is a gene that encodes the SMN protein (full and truncated) in humans.
# Gene
The SMN2 gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions... | SMN2
Survival of motor neuron 2 (SMN2) is a gene that encodes the SMN protein (full and truncated) in humans.[1][2]
# Gene
The SMN2 gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and de... | https://www.wikidoc.org/index.php/SMN2 | |
60a69251b4f59a839d8dd640be6245aa898b2358 | wikidoc | SNF8 | SNF8
Vacuolar-sorting protein SNF8 is a protein that in humans is encoded by the SNF8 gene.
# Model organisms
Model organisms have been used in the study of SNF8 function. A conditional knockout mouse line, called Snf8tm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a hig... | SNF8
Vacuolar-sorting protein SNF8 is a protein that in humans is encoded by the SNF8 gene.[1][2][3]
# Model organisms
Model organisms have been used in the study of SNF8 function. A conditional knockout mouse line, called Snf8tm1a(EUCOMM)Wtsi[8][9] was generated as part of the International Knockout Mouse Consortium... | https://www.wikidoc.org/index.php/SNF8 | |
7ce66b66f6598b8bbeec05d24087e539e5eedad4 | wikidoc | SNX5 | SNX5
Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the mammalian... | SNX5
Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.[1][2][3]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the... | https://www.wikidoc.org/index.php/SNX5 | |
6fc528794e1b966535a55e218837e73028a7b689 | wikidoc | SNX9 | SNX9
Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil ... | SNX9
Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.[1][2][3]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a co... | https://www.wikidoc.org/index.php/SNX9 | |
359689c08e29acb1a17d962e954b1334364baf34 | wikidoc | SOAP | SOAP
SOAP (see below for name and origins) is a protocol for exchanging XML-based messages over computer networks, normally using HTTP/HTTPS. SOAP forms the foundation layer of the web services protocol stack providing a basic messaging framework upon which abstract layers can be built.
As a layman's example of how SO... | SOAP
SOAP (see below for name and origins) is a protocol for exchanging XML-based messages over computer networks, normally using HTTP/HTTPS. SOAP forms the foundation layer of the web services protocol stack providing a basic messaging framework upon which abstract layers can be built.
As a layman's example of how S... | https://www.wikidoc.org/index.php/SOAP | |
5d53c8fc65c6e3cdddab238ea85e2862aa7b5929 | wikidoc | SOD1 | SOD1
Superoxide dismutase also known as superoxide dismutase 1 or SOD1 is an enzyme that in humans is encoded by the SOD1 gene, located on chromosome 21. SOD1 is one of three human superoxide dismutases. It is implicated in apoptosis and amyotrophic lateral sclerosis.
# Structure
SOD1 is a 32 kDa homodimer which form... | SOD1
Superoxide dismutase [Cu-Zn] also known as superoxide dismutase 1 or SOD1 is an enzyme that in humans is encoded by the SOD1 gene, located on chromosome 21. SOD1 is one of three human superoxide dismutases.[1][2] It is implicated in apoptosis and amyotrophic lateral sclerosis.[2]
# Structure
SOD1 is a 32 kDa hom... | https://www.wikidoc.org/index.php/SOD1 | |
3d9cc6ee6c1e0f6edaeed92f4862d3f586545407 | wikidoc | SOD2 | SOD2
Superoxide dismutase 2, mitochondrial (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is an enzyme which in humans is encoded by the SOD2 gene on chromosome 6. A related pseudogene has been identified on chromosome 1. Alternative splicing of this gene results in multiple transcript variants... | SOD2
Superoxide dismutase 2, mitochondrial (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is an enzyme which in humans is encoded by the SOD2 gene on chromosome 6.[1][2] A related pseudogene has been identified on chromosome 1. Alternative splicing of this gene results in multiple transcript v... | https://www.wikidoc.org/index.php/SOD2 | |
5118eae19de678738dc491238534545706a800ab | wikidoc | SOS1 | SOS1
Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.
# Function
RAS genes (e.g., MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, an... | SOS1
Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.[1][2]
# Function
RAS genes (e.g., MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS prote... | https://www.wikidoc.org/index.php/SOS1 | |
f16764fbc60f7e5ccdb78beb8b67d9ab6a47b183 | wikidoc | SOX2 | SOX2
SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has a critical role in maintenance of embryonic and neural stem cells.
Sox2 is a member of the Sox family of transcript... | SOX2
SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has a critical role in maintenance of embryonic and neural stem cells.[1]
Sox2 is a member of the Sox family of transc... | https://www.wikidoc.org/index.php/SOX2 | |
333fc3f29c0ecd019d3149d0d8daee9ba64d14a3 | wikidoc | SOX4 | SOX4
Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.
# Function
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein m... | SOX4
Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.[1][2][3]
# Function
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded... | https://www.wikidoc.org/index.php/SOX4 | |
eaf772c82ffeaf037a05300c8c851c0b3b486634 | wikidoc | SOX6 | SOX6
Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene.
# Function
The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove o... | SOX6
Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene.[1][2]
# Function
The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor g... | https://www.wikidoc.org/index.php/SOX6 | |
a9869837191b5c45e124d60b2ec6e2bb99c18c47 | wikidoc | SOX9 | SOX9
Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene.
# Function
SOX-9 recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-... | SOX9
Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene.[1][2]
# Function
SOX-9 recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of th... | https://www.wikidoc.org/index.php/SOX9 | |
271bdfdb7d61a10e105ed590f8b92173cc6f5990 | wikidoc | SPEN | SPEN
Msx2-interacting protein is a protein that in humans is encoded by the SPEN gene.
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation,... | SPEN
Msx2-interacting protein is a protein that in humans is encoded by the SPEN gene.[1][2][3]
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deac... | https://www.wikidoc.org/index.php/SPEN | |
092810f8b6160175abd53e78f13ecb2bc8444270 | wikidoc | SPI1 | SPI1
Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.
# Function
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found on enhance... | SPI1
Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.[1]
# Function
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development[citation needed]. The nuclear protein binds to a purine-rich sequence known as the PU... | https://www.wikidoc.org/index.php/SPI1 | |
90267c3061f0a6a124f9f2ed6a0c39cfc1be4507 | wikidoc | SPOP | SPOP
Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene.
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, t... | SPOP
Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene.[1][2][3]
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. I... | https://www.wikidoc.org/index.php/SPOP | |
15e478cd435005e1abdfcdc2344113e2f2e14d2a | wikidoc | SRA1 | SRA1
Steroid receptor RNA activator 1 also known as steroid receptor RNA activator protein (SRAP) is a protein that in humans is encoded by the SRA1 gene. The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1. This functional RNA also encodes a protein.
# Function
Th... | SRA1
Steroid receptor RNA activator 1 also known as steroid receptor RNA activator protein (SRAP) is a protein that in humans is encoded by the SRA1 gene.[1][2] The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1. This functional RNA also encodes a protein.[3]
# F... | https://www.wikidoc.org/index.php/SRA1 | |
365c9a7097f1151a0020b88c248dc378576a5533 | wikidoc | SS18 | SS18
Protein SSXT is a protein that in humans is encoded by the SS18 gene.
# Function
SS18 is a member of the human SWI/SNF chromatin remodeling complex.
# Clinical significance
SS18 is involved in a chromosomal translocation commonly found in synovial sarcoma.
# Interactions
SS18 has been shown to interact with:
- ... | SS18
Protein SSXT is a protein that in humans is encoded by the SS18 gene.[1][2][3]
# Function
SS18 is a member of the human SWI/SNF chromatin remodeling complex.[4][5][6]
# Clinical significance
SS18 is involved in a chromosomal translocation commonly found in synovial sarcoma.[7]
# Interactions
SS18 has been show... | https://www.wikidoc.org/index.php/SS18 | |
a9fa84dd393964d0c4fa2278c23cf28fef9553e7 | wikidoc | SSX6 | SSX6
SSX family member 6, pseudogene is a protein that in humans is encoded by the SSX6 gene.
# Function
This gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral... | SSX6
SSX family member 6, pseudogene is a protein that in humans is encoded by the SSX6 gene.
[1]
# Function
This gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously hu... | https://www.wikidoc.org/index.php/SSX6 | |
3087a3dc5233e6678b43816da441c49eaf4bdddd | wikidoc | ST14 | ST14
Suppressor of tumorigenicity 14 protein, also known as matriptase, is a protein that in humans is encoded by the ST14 gene. ST14 orthologs have been identified in most mammals for which complete genome data are available.
# Function
Matriptase is an epithelial-derived, integral membrane serine protease. This prot... | ST14
Suppressor of tumorigenicity 14 protein, also known as matriptase, is a protein that in humans is encoded by the ST14 gene.[1] ST14 orthologs[2] have been identified in most mammals for which complete genome data are available.
# Function
Matriptase is an epithelial-derived, integral membrane serine protease. Th... | https://www.wikidoc.org/index.php/ST14 | |
b58017e2187ec8ec6042bb8c0916c7f8aa06945c | wikidoc | STIL | STIL
SCL-interrupting locus protein is a protein that in humans is encoded by the STIL gene.
This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes... | STIL
SCL-interrupting locus protein is a protein that in humans is encoded by the STIL gene.[1][2]
This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chro... | https://www.wikidoc.org/index.php/STIL | |
379cc7a8733705e8dded4081fed359b7749b1070 | wikidoc | STK4 | STK4
Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.
# Function
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p (sterile 20 protein) kinase, which acts upstream of the stress-induced mitogen-activated protein kinase (M... | STK4
Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.[1][2][3]
# Function
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p (sterile 20 protein) kinase, which acts upstream of the stress-induced mitogen-activated protein... | https://www.wikidoc.org/index.php/STK4 | |
019568b62816c92105aba88f1bda12acdd114a3a | wikidoc | STX2 | STX2
Syntaxin-2, also known as epimorphin, is a protein that in humans is encoded by the STX2 gene.
The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gen... | STX2
Syntaxin-2, also known as epimorphin, is a protein that in humans is encoded by the STX2 gene.[1][2][3]
The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product o... | https://www.wikidoc.org/index.php/STX2 | |
e20f35d28f593323a9daf2d99676ad13be3db4f5 | wikidoc | STX7 | STX7
Syntaxin-7 is a protein that in humans is encoded by the STX7 gene.
In melanocytic cells STX7 gene expression may be regulated by MITF.
# Interactions
STX7 has been shown to interact with STX8, VPS18, Vesicle-associated membrane protein 8 and VPS11. | STX7
Syntaxin-7 is a protein that in humans is encoded by the STX7 gene.[1][2]
In melanocytic cells STX7 gene expression may be regulated by MITF.[3]
# Interactions
STX7 has been shown to interact with STX8,[4] VPS18,[5] Vesicle-associated membrane protein 8[4][6] and VPS11.[5] | https://www.wikidoc.org/index.php/STX7 | |
8dfbe49f29879c27ad23eb01f0127d7205b15a7c | wikidoc | STX8 | STX8
Syntaxin-8 is a protein that in humans is encoded by the STX8 gene.
Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization. The protein has been shown to form the SNARE complex with syntaxin 7, vti1b and endobrevin. These function as the machinery for the homotypic fusion of late endoso... | STX8
Syntaxin-8 is a protein that in humans is encoded by the STX8 gene.[1][2][3]
Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization.[4] The protein has been shown to form the SNARE complex with syntaxin 7, vti1b and endobrevin. These function as the machinery for the homotypic fusion o... | https://www.wikidoc.org/index.php/STX8 | |
9c1d8ca9bd9c531dfcf5079f5ae38a2fe192a144 | wikidoc | SUFU | SUFU
Suppressor of fused homolog is a protein that in humans is encoded by the SUFU gene.
# Function
SUFU encodes a component of the sonic hedgehog (SHH) / patched (PTCH) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-pred... | SUFU
Suppressor of fused homolog is a protein that in humans is encoded by the SUFU gene.[1][2]
# Function
SUFU encodes a component of the sonic hedgehog (SHH) / patched (PTCH) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with canc... | https://www.wikidoc.org/index.php/SUFU | |
f9654674a34a67cf4b9115a97b5e9dc83262ecc3 | wikidoc | SYT1 | SYT1
Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene.
# Function
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as sensors for calcium ions (Ca2+)in the process of vesicular trafficking and exocytosis. Calcium ion binding to synaptotagmin I participates ... | SYT1
Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene.[1]
# Function
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as sensors for calcium ions (Ca2+)in the process of vesicular trafficking and exocytosis. Calcium ion binding to synaptotagmin I participa... | https://www.wikidoc.org/index.php/SYT1 | |
083fbe70b73310be65909633f801014efa19f95f | wikidoc | SZT2 | SZT2
Seizure threshold 2 homolog is a protein that in humans is encoded by the SZT2 gene.
# Function
The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxid... | SZT2
Seizure threshold 2 homolog is a protein that in humans is encoded by the SZT2 gene.[1]
# Function
The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to ... | https://www.wikidoc.org/index.php/SZT2 | |
6791c4a9bff2c7e2231426d35ad0149647753887 | wikidoc | Seed | Seed
A seed is a small embryonic plant enclosed in a covering called the seed coat, usually with some stored food. It is the product of the ripened ovule of gymnosperm and angiosperm plants which occurs after fertilization and some growth within the mother plant. The formation of the seed completes the process of rep... | Seed
A seed is a small embryonic plant enclosed in a covering called the seed coat, usually with some stored food. It is the product of the ripened ovule of gymnosperm and angiosperm plants which occurs after fertilization and some growth within the mother plant. The formation of the seed completes the process of re... | https://www.wikidoc.org/index.php/Seed | |
42429b2d8c9491613874a3400cadeff617e0b151 | wikidoc | Shq1 | Shq1
Shq1p is a protein involved in the rRNA processing pathway. It was discovered by Pok Yang in the Chanfreau labratory at UCLA. Depletion of Shq1p has led to decreased level of various H/ACA box snoRNAs (H/ACA box snoRNAs are responsible for pseuduridylation of pre-rRNA) and certain pre-rRNA intermediates.
# Back... | Shq1
Shq1p is a protein involved in the rRNA processing pathway. It was discovered by Pok Yang in the Chanfreau labratory at UCLA. Depletion of Shq1p has led to decreased level of various H/ACA box snoRNAs (H/ACA box snoRNAs are responsible for pseuduridylation of pre-rRNA) and certain pre-rRNA intermediates.[1]
# ... | https://www.wikidoc.org/index.php/Shq1 | |
5f4a4e14e2ae1d815bca6913d5fe0a7ae66ab16b | wikidoc | Slug | Slug
# Overview
Slug is a common non-scientific word which is most often applied to any gastropod mollusk whatsoever that has a very reduced shell, a small internal shell, or no shell at all. A slug-like body is an adaptation which has occurred many times in various groups of snails.
The common name "slug" is most oft... | Slug
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
# Overview
Slug is a common non-scientific word which is most often applied to any gastropod mollusk whatsoever that has a very reduced shell, a small internal shell, or no shell at all. A slug-like body is an adaptation which has occurred many times in various ... | https://www.wikidoc.org/index.php/Slug | |
b082331711aaa78d3ba471a69ac9d54031ea942f | wikidoc | Snus | Snus
Snus (pronounced Template:IPA) is a moist powder tobacco product that is consumed by placing it under the upper lip for extended periods of time. It was originally developed from powdered snuff that was inhaled through the nostrils. Snus is manufactured and consumed primarily in Sweden and Norway. A version has re... | Snus
Snus (pronounced Template:IPA) is a moist powder tobacco product that is consumed by placing it under the upper lip for extended periods of time. It was originally developed from powdered snuff that was inhaled through the nostrils. Snus is manufactured and consumed primarily in Sweden and Norway. A version has r... | https://www.wikidoc.org/index.php/Snus | |
02a74aab8ceaf1ae91c6953d0446555f0dd50373 | wikidoc | Sobp | Sobp
Sine oculis-binding protein homolog (SOBP) also known as Jackson circler protein 1 (JXC1) is a protein that in humans is encoded by the SOBP gene. The first SOBP gene was identified in Drosophila melanogaster in a yeast two-hybrid screen that used the SIX domain of the Sine oculis protein as bait. In most genomes... | Sobp
Sine oculis-binding protein homolog (SOBP) also known as Jackson circler protein 1 (JXC1) is a protein that in humans is encoded by the SOBP gene.[1][2][3] The first SOBP gene was identified in Drosophila melanogaster in a yeast two-hybrid screen that used the SIX domain of the Sine oculis protein as bait.[4] In... | https://www.wikidoc.org/index.php/Sobp | |
53d029a699cbd792d1a5686ef7ff6220b01434d1 | wikidoc | Soil | Soil
Soil is the naturally occurring, unconsolidated or loose covering of broken rock particles and decaying organic matter (humus) on the surface of the Earth, capable of supporting life. In simple terms, soil has three components: solid, liquid, and gas. The solid phase is a mixture of mineral and organic matter. Soi... | Soil
Soil is the naturally occurring, unconsolidated or loose covering of broken rock particles and decaying organic matter (humus) on the surface of the Earth, capable of supporting life.[1] In simple terms, soil has three components: solid, liquid, and gas. The solid phase is a mixture of mineral and organic matter.... | https://www.wikidoc.org/index.php/Soil | |
7533be241941d531d31197b17078fee30f7f682e | wikidoc | Soma | Soma
Soma (Sanskrit: सोमः), or Haoma (Avestan), from Proto-Indo-Iranian *sauma-, was a ritual drink of importance among the early Indo-Iranians, and the later Vedic and greater Persian cultures. It is frequently mentioned in the Rigveda, which contains many hymns praising its energizing or intoxicating qualities. In th... | Soma
Click here for the drug Soma.
Soma (Sanskrit: सोमः), or Haoma (Avestan), from Proto-Indo-Iranian *sauma-, was a ritual drink of importance among the early Indo-Iranians, and the later Vedic and greater Persian cultures. It is frequently mentioned in the Rigveda, which contains many hymns praising its energizing o... | https://www.wikidoc.org/index.php/Soma | |
fd6c18aadea6c65feb29a30d6802f362c31fb7eb | wikidoc | Suet | Suet
Suet (/ˈsuː.ɪt/) is raw beef or mutton fat, especially the hard fat found around the loins and kidneys.
Suet has a melting point of between 45° and 50°C. (113° and 122°F.), and congeals between 37° and 40°C. (98.6° and 104°F.).
# Uses
The primary use of suet is to make tallow, although it is also used as an ingr... | Suet
Suet (/ˈsuː.ɪt/) is raw beef or mutton fat, especially the hard fat found around the loins and kidneys.
Suet has a melting point of between 45° and 50°C. (113° and 122°F.), and congeals between 37° and 40°C. (98.6° and 104°F.).
# Uses
The primary use of suet is to make tallow, although it is also used as an ing... | https://www.wikidoc.org/index.php/Suet | |
e168c8547064763b494d33f09d0d762916a6276c | wikidoc | TAC1 | TAC1
Preprotachykinin-1, (abbreviated PPT-1, PPT-I, or PPT-A), is a precursor protein that in humans is encoded by the TAC1 gene.
# Isoforms and derivatives
The protein has four isoforms—alpha-, beta-, gamma-, and delta-PPT—which can variably undergo post-translational modification to produce neurokinin A (formerly kn... | TAC1
Preprotachykinin-1, (abbreviated PPT-1, PPT-I, or PPT-A), is a precursor protein that in humans is encoded by the TAC1 gene.[1][2]
# Isoforms and derivatives
The protein has four isoforms—alpha-, beta-, gamma-, and delta-PPT—which can variably undergo post-translational modification to produce neurokinin A (form... | https://www.wikidoc.org/index.php/TAC1 | |
182123bf33718210014ddcf12814a743a4b17fa0 | wikidoc | TACT | TACT
# Official Title
Trial to Assess Chelation Therapy (TACT)
# Objective
The purpose of this study is to determine the safety and effectiveness of ethylene diamine tetra-acetic (EDTA) chelation therapy in individuals with coronary artery disease.
# Sponsor
Mt. Sinai Medical Center, Miami
# Timeline
The previous i... | TACT
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]
# Official Title
Trial to Assess Chelation Therapy (TACT)
# Objective
The purpose of this study is to determine the safety and effectiveness of ethylene diamine tetra-acetic (EDTA) chelation therapy in indivi... | https://www.wikidoc.org/index.php/TACT | |
625edd7827fbc3fa122b9662801a97e0015364d9 | wikidoc | TAF1 | TAF1
Transcription initiation factor TFIID subunit 1, also known as transcription initiation factor TFIID 250 kDa subunit (TAFII-250) or TBP-associated factor 250 kDa (p250), is a protein that in humans is encoded by the TAF1 gene.
# Function
Initiation of transcription by RNA polymerase II requires the activities of ... | TAF1
Transcription initiation factor TFIID subunit 1, also known as transcription initiation factor TFIID 250 kDa subunit (TAFII-250) or TBP-associated factor 250 kDa (p250), is a protein that in humans is encoded by the TAF1 gene.[1][2]
# Function
Initiation of transcription by RNA polymerase II requires the activit... | https://www.wikidoc.org/index.php/TAF1 | |
baa508ddd128060ba8d0e2173aa418f487dcee28 | wikidoc | TAF4 | TAF4
Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene.
# Function
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds ... | TAF4
Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene.[1][2][3]
# Function
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), wh... | https://www.wikidoc.org/index.php/TAF4 | |
6f75c82e34196f27a4bdc0befde587f89bca4923 | wikidoc | TAF7 | TAF7
Transcription initiation factor TFIID subunit 7 also known as TAFII55 is a protein that in humans is encoded by the TAF7 gene.
# Function
The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a ... | TAF7
Transcription initiation factor TFIID subunit 7 also known as TAFII55 is a protein that in humans is encoded by the TAF7 gene.[1]
# Function
The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene i... | https://www.wikidoc.org/index.php/TAF7 | |
f2b7660ca2703b3f98458016985d2834d4d051dd | wikidoc | TAF9 | TAF9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a protein that in humans is encoded by the TAF9 gene.
# Function
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein complex that coordinates these... | TAF9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a protein that in humans is encoded by the TAF9 gene.[1][2]
# Function
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein complex that coordinate... | https://www.wikidoc.org/index.php/TAF9 | |
c032c9bc4edc39ac35cc4069dea49dbb9a4ac21c | wikidoc | TAL2 | TAL2
T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.
# Function
TAL2 is a member of the basic helix-loop-helix family of transcription factors.
# Clinical significance
Tumor-specific alterations of the TAL2 gene occurs in some patients with T-cell acu... | TAL2
T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.[1][2]
# Function
TAL2 is a member of the basic helix-loop-helix family of transcription factors.[3]
# Clinical significance
Tumor-specific alterations of the TAL2 gene occurs in some patients with ... | https://www.wikidoc.org/index.php/TAL2 | |
c6a5927b32c31c3c12effd7d1d977ed5777578c8 | wikidoc | TBCE | TBCE
Tubulin-specific chaperone E is a protein that in humans is encoded by the TBCE gene.
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing... | TBCE
Tubulin-specific chaperone E is a protein that in humans is encoded by the TBCE gene.[1][2]
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stab... | https://www.wikidoc.org/index.php/TBCE | |
b5a48b04f2adce89bd52a6d6575a9bcafffe7d13 | wikidoc | TBR1 | TBR1
T-box, brain, 1 is a transcription factor protein important in vertebrate embryo development. It is encoded by the TBR1 gene. This gene is also known by several other names: T-Brain 1, TBR-1, TES-56, and MGC141978. TBR1 is a member of the TBR1 subfamily of T-box family transcription factors, which share a common... | TBR1
T-box, brain, 1 is a transcription factor protein important in vertebrate embryo development. It is encoded by the TBR1 gene.[1][2] This gene is also known by several other names: T-Brain 1, TBR-1, TES-56, and MGC141978.[1] TBR1 is a member of the TBR1 subfamily of T-box family transcription factors, which shar... | https://www.wikidoc.org/index.php/TBR1 | |
afbdea321d0ee17d1fbbe3b53a8fc028914690d1 | wikidoc | TBX1 | TBX1
T-box transcription factor TBX1 also known as T-box protein 1 and testis-specific T-box protein is a protein that in humans is encoded by the TBX1 gene. Genes in the T-box family are transcription factors that play important roles in the formation of tissues and organs during embryonic development. To carry out th... | TBX1
T-box transcription factor TBX1 also known as T-box protein 1 and testis-specific T-box protein is a protein that in humans is encoded by the TBX1 gene.[1] Genes in the T-box family are transcription factors that play important roles in the formation of tissues and organs during embryonic development.[2] To carry... | https://www.wikidoc.org/index.php/TBX1 | |
229d282246d5a3d03163019c06a94323d395043b | wikidoc | TBX2 | TBX2
T-box transcription factor 2 Tbx2 is a transcription factor that is encoded by the Tbx2 gene on chromosome 17q21-22 in humans. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Tbx2 and Tbx3 are the only T-box transcription factors that act a... | TBX2
T-box transcription factor 2 Tbx2 is a transcription factor that is encoded by the Tbx2 gene on chromosome 17q21-22 in humans.[1][2][3] This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Tbx2 and Tbx3 are the only T-box transcription factors ... | https://www.wikidoc.org/index.php/TBX2 | |
49ae8e1e97421c4a848c9c17236f6789071cb7f2 | wikidoc | TBX6 | TBX6
T-box 6 is a protein that in humans is encoded by the TBX6 gene.
# Function
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in m... | TBX6
T-box 6 is a protein that in humans is encoded by the TBX6 gene.[1]
# Function
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies ... | https://www.wikidoc.org/index.php/TBX6 | |
97c5b16a9d72d7e33ac7f265179d5893ccd07e28 | wikidoc | TCF3 | TCF3
Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling) expression.
# Function
This gene encodes a member of the E protein (class... | TCF3
Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene.[1][2][3] TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling) expression.[4]
# Function
This gene encodes a member of the E p... | https://www.wikidoc.org/index.php/TCF3 | |
7ed9cfc56d731b3b797d10ee40f4a0d8a373a8c2 | wikidoc | TCF4 | TCF4
Transcription factor 4 (TCF-4) also known as immunoglobulin transcription factor 2 (ITF-2) is a protein that in humans is encoded by the TCF4 gene located on chromosome 18q21.2.
# Function
TCF4 proteins act as transcription factors which will bind to the immunoglobulin enhancer mu-E5/kappa-E2 motif. TCF4 activat... | TCF4
Transcription factor 4 (TCF-4) also known as immunoglobulin transcription factor 2 (ITF-2) is a protein that in humans is encoded by the TCF4 gene located on chromosome 18q21.2.[1]
# Function
TCF4 proteins act as transcription factors which will bind to the immunoglobulin enhancer mu-E5/kappa-E2 motif. TCF4 act... | https://www.wikidoc.org/index.php/TCF4 | |
1bfad59bd8d86836b24705d09f456ce0b3c9e7f0 | wikidoc | TDP1 | TDP1
Tyrosyl-DNA phosphodiesterase 1 is an enzyme that in humans is encoded by the TDP1 gene.
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of Type I topoisomerase and the 3-prime phosp... | TDP1
Tyrosyl-DNA phosphodiesterase 1 is an enzyme that in humans is encoded by the TDP1 gene.[1][2][3]
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of Type I topoisomerase and the 3-p... | https://www.wikidoc.org/index.php/TDP1 | |
97c12ef4cdde83bd5dfc44a68d00f347563cecd4 | wikidoc | TECR | TECR
Trans-2,3-enoyl-CoA reductase is an enzyme that in humans is encoded by the TECR gene.
This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 seque... | TECR
Trans-2,3-enoyl-CoA reductase is an enzyme that in humans is encoded by the TECR gene.[1]
This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 s... | https://www.wikidoc.org/index.php/TECR | |
9df7c7f8a5fe886d8f9fa40d76899508979e9c9a | wikidoc | TFAM | TFAM
Mitochondrial transcription factor A, abbreviated as TFAM or mtTFA, is a protein that in humans is encoded by the TFAM gene.
# Function
This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. TFAM b... | TFAM
Mitochondrial transcription factor A, abbreviated as TFAM or mtTFA, is a protein that in humans is encoded by the TFAM gene.[1][2]
# Function
This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication.... | https://www.wikidoc.org/index.php/TFAM | |
2880ec6536289be9680ad6227833be6582c59e01 | wikidoc | TFE3 | TFE3
Transcription factor E3 is a protein that in humans is encoded by the TFE3 gene.
# Function
TFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991).
# Interactions
TFE3 ... | TFE3
Transcription factor E3 is a protein that in humans is encoded by the TFE3 gene.[1][2][3]
# Function
TFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991).[supplied by... | https://www.wikidoc.org/index.php/TFE3 | |
1e1955afecd5c3681d7a317ddda669a5543c9d2b | wikidoc | TFEB | TFEB
Transcription factor EB is a protein that in humans is encoded by the TFEB gene.
# Function
TFEB is a master gene for lysosomal biogenesis. It encodes a transcription factor that coordinates expression of lysosomal hydrolases, membrane proteins and genes involved in autophagy. Upon nutrient depletion and under ab... | TFEB
Transcription factor EB is a protein that in humans is encoded by the TFEB gene.[1][2]
# Function
TFEB is a master gene for lysosomal biogenesis.[3] It encodes a transcription factor that coordinates expression of lysosomal hydrolases, membrane proteins and genes involved in autophagy.[3][4] Upon nutrient deplet... | https://www.wikidoc.org/index.php/TFEB | |
5435c6076bd0ef9541522746b05034b8cf93dcaa | wikidoc | TGM6 | TGM6
Transglutaminase 6 is a protein that in humans is encoded by the TGM6 gene.
# Function
The protein encoded by this gene belongs to the transglutaminase superfamily. It catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Mutations in this gene are associated with spinocerebellar ... | TGM6
Transglutaminase 6 is a protein that in humans is encoded by the TGM6 gene.
[1]
# Function
The protein encoded by this gene belongs to the transglutaminase superfamily. It catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Mutations in this gene are associated with spinocerebe... | https://www.wikidoc.org/index.php/TGM6 | |
8902f3882b594ad204559ea8e0c5930dc8d67c72 | wikidoc | TIG1 | TIG1
# Overview
Tazarotene-induced gene-1 (TIG1) is a protein which has been implicated as a putative tumor suppressor. It is structurally similar to the protein latexin, which has also been shown to demonstrate some tumor suppression activity (Liang et al., 2007). TIG1 is thought to be a transmembrane protein, and i... | TIG1
# Overview
Tazarotene-induced gene-1 (TIG1) is a protein which has been implicated as a putative tumor suppressor. It is structurally similar to the protein latexin, which has also been shown to demonstrate some tumor suppression activity (Liang et al., 2007). TIG1 is thought to be a transmembrane protein, and i... | https://www.wikidoc.org/index.php/TIG1 | |
dc00654df3f13e509abb7649e1c41fdb07effb78 | wikidoc | TLK1 | TLK1
Serine/threonine-protein kinase tousled-like 1 is an enzyme that in humans is encoded by the TLK1 gene.
# Function
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.
# Interactions
TLK1 has been sho... | TLK1
Serine/threonine-protein kinase tousled-like 1 is an enzyme that in humans is encoded by the TLK1 gene.[1][2][3]
# Function
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM][3]
#... | https://www.wikidoc.org/index.php/TLK1 | |
07a258209fde128d3c424de7f624d66249d2d8db | wikidoc | TLK2 | TLK2
Serine/threonine-protein kinase tousled-like 2 is an enzyme that in humans is encoded by the TLK2 gene.
# Function
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. These are different from other "t... | TLK2
Serine/threonine-protein kinase tousled-like 2 is an enzyme that in humans is encoded by the TLK2 gene.[1][2][3]
# Function
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. These are different fro... | https://www.wikidoc.org/index.php/TLK2 | |
908f34cc1df02a8c8eadb537a1c42ed24003dec5 | wikidoc | TLN1 | TLN1
Talin-1 is a protein that in humans is encoded by the TLN1 gene. Talin-1 is ubiquitously expressed, and is localized to costamere structures in cardiac and skeletal muscle cells, and to focal adhesions in smooth muscle and non-muscle cells. Talin-1 functions to mediate cell-cell adhesion via the linkage of integri... | TLN1
Talin-1 is a protein that in humans is encoded by the TLN1 gene.[1][2] Talin-1 is ubiquitously expressed, and is localized to costamere structures in cardiac and skeletal muscle cells, and to focal adhesions in smooth muscle and non-muscle cells. Talin-1 functions to mediate cell-cell adhesion via the linkage of ... | https://www.wikidoc.org/index.php/TLN1 | |
67223d1e80f50e13bae0d80752d7ea0b1ae8030d | wikidoc | TLN2 | TLN2
Talin 2 is a protein in humans that is encoded by the TLN2 gene. It belongs to the talin protein family.
This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments. Talin-2 is expressed at high levels in cardiac muscle and functions to ... | TLN2
Talin 2 is a protein in humans that is encoded by the TLN2 gene. It belongs to the talin protein family.
This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments. Talin-2 is expressed at high levels in cardiac muscle and functions to ... | https://www.wikidoc.org/index.php/TLN2 | |
abfa2c4c8e5ebd5f3cb429d4405389c0bf5ac2fd | wikidoc | TLR2 | TLR2
Toll-like receptor 2 also known as TLR2 is a protein that in humans is encoded by the TLR2 gene. TLR2 has also been designated as CD282 (cluster of differentiation 282). TLR2 is one of the toll-like receptors and plays a role in the immune system. TLR2 is a membrane protein, a receptor, which is expressed on the s... | TLR2
Toll-like receptor 2 also known as TLR2 is a protein that in humans is encoded by the TLR2 gene.[1] TLR2 has also been designated as CD282 (cluster of differentiation 282). TLR2 is one of the toll-like receptors and plays a role in the immune system. TLR2 is a membrane protein, a receptor, which is expressed on t... | https://www.wikidoc.org/index.php/TLR2 | |
57f674250a72e00f4c74bd1407f88cb9f8e1078b | wikidoc | TLR3 | TLR3
Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene. TLR3 is a member of the toll-like receptor family of pattern recognition receptors of the innate immune system.
# Function
TLR3 is a member of the toll-like receptor (TLR) fami... | TLR3
Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene.[1] TLR3 is a member of the toll-like receptor family of pattern recognition receptors of the innate immune system.
# Function
TLR3 is a member of the toll-like receptor (TLR) ... | https://www.wikidoc.org/index.php/TLR3 | |
21a4da2587cedddef2f3de54772fc4ebdc3991a1 | wikidoc | TLR4 | TLR4
Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. Its activation leads to an intracellular signaling pathway NF-κB and inflammatory cytokine producti... | TLR4
Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. Its activation leads to an intracellular signaling pathway NF-κB and inflammatory cytokine product... | https://www.wikidoc.org/index.php/TLR4 | |
7209f46e5f42c71dd0c24c8b80b3c841a6f72846 | wikidoc | TLR5 | TLR5
Toll-like receptor 5, also known as TLR5, is a protein which in humans is encoded by the TLR5 gene. It is a member of the toll-like receptor (TLR) family. TLR5 is known to recognize bacterial flagellin from invading mobile bacteria. Its has been shown to be involved in the onset of many diseases, which includes In... | TLR5
Toll-like receptor 5, also known as TLR5, is a protein which in humans is encoded by the TLR5 gene.[1] It is a member of the toll-like receptor (TLR) family. TLR5 is known to recognize bacterial flagellin from invading mobile bacteria.[2] Its has been shown to be involved in the onset of many diseases, which incl... | https://www.wikidoc.org/index.php/TLR5 | |
16072cd8b2b22d045fe8081e9683addfb6f8a2b8 | wikidoc | TLR7 | TLR7
Toll-like receptor 7, also known as TLR7, is a protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds. It is a member of the toll-like receptor (TLR) family and detects single stranded RNA.
# Function
The TLR family plays an important role in pathogen recognition and activat... | TLR7
Toll-like receptor 7, also known as TLR7, is a protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds.[1] It is a member of the toll-like receptor (TLR) family and detects single stranded RNA.
# Function
The TLR family plays an important role in pathogen recognition and act... | https://www.wikidoc.org/index.php/TLR7 | |
ebee5bc2b8217f0491f9e953b16f05f1ef26913c | wikidoc | TLR8 | TLR8
Toll-like receptor 8 is a protein that in humans is encoded by the TLR8 gene. TLR8 has also been designated as CD288 (cluster of differentiation 288). It is a member of the toll-like receptor (TLR) family.
# Function
TLR8 seems to function differently in humans and mice. Until recently, TLR8 was believed to be n... | TLR8
Toll-like receptor 8 is a protein that in humans is encoded by the TLR8 gene.[1] TLR8 has also been designated as CD288 (cluster of differentiation 288). It is a member of the toll-like receptor (TLR) family.
# Function
TLR8 seems to function differently in humans and mice. Until recently, TLR8 was believed to ... | https://www.wikidoc.org/index.php/TLR8 | |
ff5a41216694922a675c53eaa6d91adf27f767ba | wikidoc | TLR9 | TLR9
Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene. TLR9 has also been designated as CD289 (cluster of differentiation 289). It is a member of the toll-like receptor (TLR) family. TLR9 is an important receptor expressed in immune system cells including dendritic cells, macrophages, natura... | TLR9
Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene.[1] TLR9 has also been designated as CD289 (cluster of differentiation 289). It is a member of the toll-like receptor (TLR) family. TLR9 is an important receptor expressed in immune system cells including dendritic cells, macrophages, na... | https://www.wikidoc.org/index.php/TLR9 | |
6310d0ad06ec6fb9638539f85160adcae335ae34 | wikidoc | TMC1 | TMC1
Transmembrane channel-like protein 1 is a protein that in humans is encoded by the TMC1 gene. TMC1 contains six transmembrane domains with both the C and N termini on the endoplasmic side of the membrane, as well as a large loop between domains 4 and 5. This topology is similar to that of transient receptor potent... | TMC1
Transmembrane channel-like protein 1 is a protein that in humans is encoded by the TMC1 gene.[1][2][3] TMC1 contains six transmembrane domains with both the C and N termini on the endoplasmic side of the membrane, as well as a large loop between domains 4 and 5. This topology is similar to that of transient recep... | https://www.wikidoc.org/index.php/TMC1 | |
8c6eb9ed5f76439f9e0145a8c563dd86ed462a40 | wikidoc | TMC2 | TMC2
Transmembrane channel-like protein 2 is a protein that in humans is encoded by the TMC2 gene.
# Function
This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, expression in the inner ear suggests that it may be crucial... | TMC2
Transmembrane channel-like protein 2 is a protein that in humans is encoded by the TMC2 gene.[1][2][3]
# Function
This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, expression in the inner ear suggests that it may ... | https://www.wikidoc.org/index.php/TMC2 | |
206f814685e12da823424649ba70890e7896e82e | wikidoc | TMC8 | TMC8
Transmembrane channel-like 8 is a protein which in humans is encoded by the TMC8 gene.
# Function
The protein encoded by this gene is an integral membrane protein that localize to the endoplasmic reticulum and is predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with... | TMC8
Transmembrane channel-like 8 is a protein which in humans is encoded by the TMC8 gene.[1][2]
# Function
The protein encoded by this gene is an integral membrane protein that localize to the endoplasmic reticulum and is predicted to form transmembrane channels. This gene encodes a transmembrane channel-like prote... | https://www.wikidoc.org/index.php/TMC8 | |
684d1080a86274377868bf45c18f1d2d711f1228 | wikidoc | TNIK | TNIK
TRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the TNIK gene.
# Function
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function.
# Interactions
TNIK has been shown to interact... | TNIK
TRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the TNIK gene.[1][2][3]
# Function
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function.[2][3]
# Interactions
TNIK has been s... | https://www.wikidoc.org/index.php/TNIK | |
a10f011ec7c3ef6157f43468b81ddf12256f7c7f | wikidoc | TNK2 | TNK2
Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene.
TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound fo... | TNK2
Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene.
[1][2][3][4][5]
TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in... | https://www.wikidoc.org/index.php/TNK2 | |
c0f97328f026f55beb13e13d0128c9fe954fd5ae | wikidoc | TOP1 | TOP1
DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene.
# Function
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which lets the br... | TOP1
DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene.
# Function
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which lets the b... | https://www.wikidoc.org/index.php/TOP1 | |
1dda46da908a2567c1c25870088b504807742526 | wikidoc | TOX3 | TOX3
TOX high mobility group box family member 3, also known as TOX3, is a human gene.
The protein encoded by this gene is a member of a subfamily of transcription factors that also includes TOX, TOX2, and TOX4 that share almost identical HMG-box DNA-binding domains which function to modify chromatin structure.
# Dise... | TOX3
TOX high mobility group box family member 3, also known as TOX3, is a human gene.[1][2]
The protein encoded by this gene is a member of a subfamily of transcription factors that also includes TOX, TOX2, and TOX4 that share almost identical HMG-box DNA-binding domains which function to modify chromatin structure.[... | https://www.wikidoc.org/index.php/TOX3 | |
36016b2bd106251cfc8b9b053013dc25ad0bcc40 | wikidoc | TP53 | TP53
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homo... | TP53
Template:Hatlink
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53... | https://www.wikidoc.org/index.php/TP53 |
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