target stringlengths 55 10.5k | src_docs listlengths 1 305 | id stringlengths 36 36 |
|---|---|---|
BACKGROUND During menopause a decreasing ovarian follicular response generally causes a fluctuation and eventual decrease in estrogen levels . This can lead to the development of various perimenopausal and postmenopausal symptoms ( for example hot flushes , night sweats , vaginal dryness ) . Dehydroepi and rostero... | [
"BACKGROUND The efficacy and safety of testosterone treatment for hypoactive sexual desire disorder in postmenopausal women not receiving estrogen therapy are unknown . METHODS We conducted a double-blind , placebo-controlled , 52-week trial in which 814 women with hypoactive sexual desire disorder were... | 41160dc6-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND Various beneficial effects derived from neuraxial blocks have been reported . However , it is unclear whether these effects have an influence on perioperative mortality and major pulmonary/cardiovascular complications . OBJECTIVES Our primary objective was to summarize Cochrane systematic review s that a... | [
"BACKGROUND The French- Language Society of Paediatric Anaesthesiologists ( ADARPEF ) design ed a 1-year prospect i ve , multicenter and anonymous study to up date both epidemiology and morbidity of regional anesthesia in children . METHODS From November 2005 to October 2006 , data from participating hospita... | 41160e02-06ff-11f0-808a-c43d1ab1c353 |
OBJECTIVE Pulpotomy is a common procedure to treat asymptomatic reversible pulpitis in primary molars . The aim of this study is to undertake a systematic review and a network meta- analysis to compare the clinical and radiographic outcomes of different pulpotomy procedures in primary molars . DATA Three auth... | [
"PURPOSE The purpose of this study was to compare the effectiveness of 5 % sodium hypochlorite ( NaOCl ) to that of ferric sulfate ( FeSO4 ) as a pulpotomy medicament in decayed primary molars . METHODS Healthy subjects between 4 and 9 years with at least 2 primary molars needing pulpotomy consented to recei... | 41160e3e-06ff-11f0-808a-c43d1ab1c353 |
Background Pregnant women and newborns are at risk for vitamin D deficiency ( VDD ) . Also , poor health outcomes for pregnant women with VDD are reported in the published literature . Objective The aim of this systematic review was to estimate the prevalence of hypovitaminosis D and the associated risk factors... | [
"OBJECTIVE Increased oxidative stress and immune dysfunction are implicated in preeclampsia ( PE ) and may contribute to the two- to fourfold increase in PE prevalence among women with type 1 diabetes . Prospect i ve measures of fat-soluble vitamins in diabetic pregnancy are therefore of interest . RESEARCH DESIG... | 41160e7a-06ff-11f0-808a-c43d1ab1c353 |
Toxicities of systemic cancer therapies are often less frequently observed in clinical trials than in clinical practice , due to the careful selection of patients with fewer comorbidities . Although guidelines exist for the estimation of chemotherapy dose , clinical factors like age , comorbid illness and extremes of... | [
"BACKGROUND To know the effectiveness and tolerance of weekly cisplatin added to radiotherapy ( RT ) in advanced carcinoma of oropharynx and nasopharynx . PATIENTS AND METHODS Stage II-IV cancer patients were r and omly assigned to either radical RT , 70 Gy/35 fractions over 7 weeks ( RT arm ) , or chemo... | 41160eb6-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND The aim of this study was to perform a st and ardized and systematic evaluation of the available evidence on multi-item shoulder-specific patient-reported outcome measures that are applicable to a wide spectrum of disorders . MATERIAL S AND METHODS A systematic review was conducted in PubMed to identify ar... | [
"Background Shoulder pain is common in primary care , and has an unfavourable outcome in many patients . Information about predictors of shoulder pain related sick leave in workers is scarce and inconsistent . The objective was to develop a clinical prediction rule for calculating the risk of shoulder pain relat... | 41160ef2-06ff-11f0-808a-c43d1ab1c353 |
Review question / objective What is the effectiveness of polyunsaturated fatty acids ( PUFA ) in reducing the clinical symptoms of paediatric bipolar disorder ( PBD ) in children and adolescents ? The objectives of this systematic review are to : • Evaluate the effectiveness of different types of PUFA in reducing... | [
"BACKGROUND Antidepressant-induced mania ( AIM ) has been described in bipolar disorder ( BD ) and has been associated with the short-allele of the serotonin transporter gene ( 5-HTT ) . We wished to investigate the frequency of and risk factors for AIM in pediatric patients with or at high risk for BD . METHOD... | 41160f2e-06ff-11f0-808a-c43d1ab1c353 |
Background People with diabetes and comorbid severe mental illness ( SMI ) form a growing population at risk of increased mortality and morbidity compared to those with diabetes or SMI alone . There is increasing interest in interventions that target diabetes in SMI in order to help to improve physical health and re... | [
"Background Patients with schizophrenia have lower longevity than the general population as a consequence of a combination of risk factors connected to the disease , lifestyle and the use of medications , which are related to weight gain . Methods A multicentric , r and omized , controlled-trial was conducted t... | 41160f6a-06ff-11f0-808a-c43d1ab1c353 |
Selenium supplementation in people with Hashimoto 's thyroiditis might reduce antibody levels and result in a decreased dosage of levothyroxine ( LT4 ) and may provide other beneficial effects ( e.g. on mood and health-related quality of life ) . The aim of our systematic review was to assess the effects of ... | [
"We recently conducted a prospect i ve , placebo‐controlled clinical study , where we could demonstrate , that a substitution of 200 μg sodium selenite for three months in patients with autoimmune thyroiditis reduced thyroid peroxidase antibody ( TPO‐Ab ) concentrations significantly . Forty‐seven patients... | 41160fa6-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND Secondary prevention is cost-effective for cardiovascular disease ( CVD ) , but uptake is suboptimal . Underst and ing barriers and facilitators to adherence to secondary prevention for CVD at multiple health system levels may inform policy . OBJECTIVES To conduct a systematic review of barriers and faci... | [
"BACKGROUND Adherence to evidence -based cardiovascular ( CV ) medications after an acute myocardial infa rct ion ( MI ) is low after the first 6 months . The use of fixed-dose combinations ( FDC ) has been shown to improve treatment adherence and risk factor control . However , no previous r and omized trial h... | 41160fe2-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND Atrial fibrillation ( AF ) and heart failure are often coexisting major public health burdens . Although several studies have reported partial restoration of systolic left ventricular ( LV ) function after catheter ablation for AF , the method is not widely applied in patients with LV dysfunction . We ... | [
"Small , single-center studies suggest that catheter ablation of atrial fibrillation ( AF ) can improve ventricular function and reduce symptoms in patients with left ventricular ( LV ) dysfunction . However , ablation has not been compared with a pharmacologic strategy for AF . The authors evaluated pat... | 4116101e-06ff-11f0-808a-c43d1ab1c353 |
UNLABELLED Health benefits from children 's independent mobility and active travel beyond school travel are largely unexplored . OBJECTIVES This review synthesized the evidence for associations of independent mobility and active travel to various destinations with physical activity , sedentary behaviour and weig... | [
"Observational longitudinal research is particularly useful for assessing etiology and prognosis and for providing evidence for clinical decision making . However , there are no structured reporting requirements for studies of this design to assist authors , editors , and readers . The authors developed and tested ... | 4116105a-06ff-11f0-808a-c43d1ab1c353 |
This study aim ed to perform a systematic review and meta- analysis of r and omized controlled trials ( RCTs ) in order to calculate the effect size of statin therapy in changing plasma cortisol concentrations . Following a systematic search in Medline , SCOPUS , Web of Science and Google Scholar data bases ( by up... | [
"In order to determine whether treatment of hyperlipidaemia with simvastatin impairs exercise stress responses and so may contribute to an excess of suicides and violent deaths , the effects of simvastatin 20 mg daily and placebo on exercise physiology were compared in 19 patients . After 6 weeks of... | 41161096-06ff-11f0-808a-c43d1ab1c353 |
Background : Smoking behaviour is a major public health problem worldwide . Several sources have confirmed the implication of genomic factors in smoking behaviour . These factors interact both with environmental factors and interventions to develop a certain behaviour . Objectives : Describing the environmental and ... | [
"Objective : To analyse the effects of smoking reduction and smoking cessation on incidence of myocardial infa rct ion after adjustment for established cardiovascular risk factors . Design : Prospect i ve cohort study with record linkage to mortality and hospital registers . The association of individual change... | 411610d2-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND Depression is a recurrent illness with high rates of chronicity , treatment-resistance and significant economic impact . There is evidence in the literature that S-adenosyl methionine ( SAMe ) , a naturally occurring compound in the human body , has antidepressant efficacy . This product may be an importan... | [
"BACKGROUND Depression is one of the most disabling diseases , and causes a significant burden both to the individual and to society . WHO data suggests that depression causes 6 % of the burden of all diseases in Europe in terms of disability adjusted life years ( DALYs ) . Yet , the knowledge of the economic imp... | 4116110e-06ff-11f0-808a-c43d1ab1c353 |
Introduction Management of atrial fibrillation ( AF ) and atrial flutter ( AFL ) in the emergency department ( ED ) varies greatly , and there are currently no United States guidelines to guide management with regard to patient disposition after ED treatment . The aim of this systematic review was to evaluate the... | [
"BACKGROUND The management of emergency department ( ED ) patients with presumed recent-onset atrial fibrillation or flutter≤48h in duration varies widely . OBJECTIVE AND METHOD We conducted a prospect i ve study across three affiliated community EDs within a large integrated health care delivery system to descri... | 4116114a-06ff-11f0-808a-c43d1ab1c353 |
Background While the clinical benefits of exercise-based cardiac rehabilitation are well established , there is extensive variation in the interventions used within these trials . It is unknown whether variations in individual components of these exercise interventions provide different relative contributions to ov... | [
"Of 22 r and omized trials of rehabilitation with exercise after myocardial infa rct ion ( MI ) , one trial had results that achieved conventional statistical significance . To determine whether or not these studies , in the aggregate , show a significant benefit of rehabilitation after myocardial infa rct io... | 41161186-06ff-11f0-808a-c43d1ab1c353 |
OBJECTIVE To review the effectiveness of interventions targeted at health care professionals and /or the structure of care in order to improve the management of diabetes in primary care , outpatient , and community setting s. RESEARCH DESIGN AND METHODS A systematic review of controlled trials evaluating the effe... | [
"This week , a series of four articles considers the place of the r and omised controlled trial as we approach the second century of experience with the concept . Its basic principle is genuine uncertainty as to which treatment arm of the trial it would be in a patient 's best interests to enter . This is not nec... | 411611c2-06ff-11f0-808a-c43d1ab1c353 |
Atrial fibrillation ( AF ) is associated with an increased stroke risk that may be reduced by therapeutic anticoagulation . However , anticoagulation is associated with an increased risk of bleeding that in some patients may outweigh the benefits in reducing the risk of stroke . We systematic ally review ed... | [
"BACKGROUND Treatment with warfarin sodium is effective for stroke prevention in atrial fibrillation but many physicians hesitate to prescribe it to elderly patients presumably because of the associated risk for bleeding and the inconvenience of frequent blood tests for the patients . METHODS In the Second Cop... | 41161208-06ff-11f0-808a-c43d1ab1c353 |
Non-specific low back pain ( LBP ) affects many people and has major socio-economic consequences . Traditional therapeutic strategies , mainly focused on biomechanical factors , have had moderate and short-term impact . Certain psychosocial factors have been linked to poor prognosis of LBP and they are increasingly c... | [
"BACKGROUND Several instruments can be used to identify patients with an unfavourable course of low back pain in general practice . However , it is unclear which instrument is the predictor of outcome . AIM To compare the predictive performance ( that is , calibration and discrimination ) of risk estimation by G... | 4116124e-06ff-11f0-808a-c43d1ab1c353 |
Abstract Purpose We evaluated a systematic review on the therapeutic efficacy of topical steroids in children with phimosis to provide data for the clinical options of pediatric phimosis . Methods We search ed the related original studies on topical steroid therapy in pediatric phimosis before August 2014 . Two... | [
"PURPOSE To compare the efficacy of three different formulations containing Betamethasone Valerate versus placebo in the topical treatment of phimosis . As a secondary goal , we compared the outcomes after 30 and 60 days of treatment . MATERIAL S AND METHODS Two hundred twenty boys aged 3 to 10 years old wit... | 4116128a-06ff-11f0-808a-c43d1ab1c353 |
Purpose Because published studies on the accuracy achieved with patient-specific guides during total knee arthroplasty ( TKA ) contradict each other , this systematic review and meta- analysis sought to compare radiological TKA outcomes when patient-specific cutting blocks ( PSCB ) were used to the outcomes when ... | [
"Abstract Purpose It was our hypothesis that patient-specific instrumentation ( PSI ) can improve the accuracy of the rotational alignment in TKA based on the concept of the system and on the potential to clearly identify pre-operatively during planning the classical anatomical l and marks that serve as referen... | 411612c6-06ff-11f0-808a-c43d1ab1c353 |
CONTEXT Several drugs are approved and available for the treatment of lower urinary tract symptoms ( LUTS ) in men and women . However , the vast majority of available data , upon which the approval and recommendation in guidelines are based , considered only the role of the monotherapies and did not evaluate possi... | [
" Objectives To evaluate the effect of association of tamsulosin/tadalafil taken daily compared with tamsulosin/placebo in the lower urinary tract with urodynamic study ( UDS ) . Methods All patients underwent baseline UDS before r and omization to tamsulosin 0.4 mg/tadalafil 5 mg ( Group 1 ; n = 20 ) or ... | 41161302-06ff-11f0-808a-c43d1ab1c353 |
AIM ( 1 ) To systematic ally review the literature on developmental outcomes from infancy to adolescence of children with complex congenital heart disease ( CHD ) who underwent early surgery ; ( 2 ) to run a meta-regression analysis on the Bayley Scales of Infant Development , Second Edition Mental Developmental In... | [
"BACKGROUND AND OBJECTIVES : Little is known about chronic neuromotor disability ( CND ) including cerebral palsy and motor impairments after acquired brain injury in children surviving early complex cardiac surgery ( CCS ) . We sought to determine the frequency and presentation of CND in this population wh... | 41161348-06ff-11f0-808a-c43d1ab1c353 |
OBJECTIVE Nonpharmacological treatments are available for attention deficit hyperactivity disorder ( ADHD ) , although their efficacy remains uncertain . The authors undertook meta-analyses of the efficacy of dietary ( restricted elimination diets , artificial food color exclusions , and free fatty acid suppleme... | [
"Electroencephalography (EEG)-neurofeedback has been shown to offer therapeutic benefits to patients with attention-deficit/hyperactivity disorder ( ADHD ) in several , mostly uncontrolled studies . This pilot study is design ed to test the feasibility and safety of using a double-blind placebo feedback-con... | 41161384-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND A previous systematic review showed that atraumatic restorative treatment ( ART ) can be an option to restore the occlusoproximal cavities in primary teeth ; however , few studies fulfilled the criteria of inclusion to generate a high level of evidence . AIM To up date the existing systematic review and ... | [
"Objectives This study aim ed to test the hypothesis that there is no difference in the survival rates of molars treated according to the conventional restorative treatment ( CRT ) using amalgam , atraumatic restorative treatment ( ART ) using high-viscosity glass ionomer , and ultraconservative treatment ( ... | 411613c0-06ff-11f0-808a-c43d1ab1c353 |
The beneficial effect of folic acid supplementation before and shortly after conception is well recognized , whereas the effect of supplementation during the second and third trimesters is controversial and poorly documented . Our aims were to systematic ally review r and omized controlled trials ( RCTs ) investigati... | [
"OBJECTIVE We evaluated the association between mothers ' use of multivitamin supplements and their infants ' risk for omphalocele , a congenital anomaly of the abdominal wall . Omphalocele can occur in certain multiple congenital anomaly patterns with neural tube defects , for which a protective effect of m... | 411613fc-06ff-11f0-808a-c43d1ab1c353 |
Abstract Aim N-3 PUFAs can potentially influence levels of inflammatory and non-inflammatory adipokines . Given the contradictory effects of n-3 PUFAs on serum levels of adipokines in type 2 diabetes , we conducted a systematic review and meta- analysis study of r and omized placebo-controlled clinical trials t... | [
"Supplementation with n-3 polyunsaturated fatty acids ( PUFA ) for 6 weeks did not alter plasma leptin concentrations in male smokers . Changes in dietary intake of saturated fatty acids ( FA ) correlated positively , whereas changes in the intake of PUFA correlated negatively to changes in plasma leptin le... | 41161438-06ff-11f0-808a-c43d1ab1c353 |
Purpose The present systematic review and meta- analysis aim ed to assess and compare the safety and efficacy of radiofrequency ( RF ) and cryoballoon ( CB ) ablation for paroxysmal atrial fibrillation ( PAF ) . RF and CB ablation are two frequently used methods for pulmonary vein isolation in PAF , but which i... | [
"Background — MRI-detected brain lesions are common after left atrial catheter ablation for symptomatic atrial fibrillation . The clinical relevance of these acute ischemic lesions is not fully understood , but ablation-related cerebral injury could contribute to cognitive dysfunction . Methods and Results — ... | 41161474-06ff-11f0-808a-c43d1ab1c353 |
Background . Increasing evidence suggests that vigorous physical activity ( VPA ) in youth may yield greater health benefits than moderate ( MPA ) or moderate-to-vigorous physical activity ( MVPA ) . The purpose of this review was to assess the relationship between PA intensity and body composition , cardior... | [
"CONTEXT Recent guidelines for treatment of overweight and obesity include recommendations for risk stratification by disease conditions and cardiovascular disease ( CVD ) risk factors , but the role of physical inactivity is not prominent in these recommendations . OBJECTIVE To quantify the influence of low card... | 411614ba-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND Psychomotor agitation is associated with different psychiatric conditions and represents an important issue in psychiatry . Current recommendations on agitation in psychiatry are not univocal . Actually , an improper assessment and management may result in unnecessary coercive or sedative treatments . A th... | [
"OBJECTIVE The authors examined the efficacy of intramuscular flunitrazepam compared with intramuscular haloperidol for the immediate control of agitated or aggressive behavior in acutely psychotic patients . METHOD Twenty-eight actively psychotic in patients , aged 20 - 60 years , who were under treatment... | 411614f6-06ff-11f0-808a-c43d1ab1c353 |
Abstract Study Design : Systematic literature review . Objective : To evaluate the diagnostic validity of manual examination techniques used to diagnose cervicogenic headache ( CGH ) . Background : Cervicogenic headache is a specific type of headache that originates from the cervical spine and is typically chroni... | [
"Study Design From a r and om population sample , those experiencing frequent headaches were identified . They were examined to determine how many fulfilled the 1990 international Headache Society classification criteria for cervicogenic headache . Objective To estimate the prevalence of cervicogenic heada... | 41161532-06ff-11f0-808a-c43d1ab1c353 |
CONTEXT Several pre clinical reports , r and omized controlled trials , systematic review s , and posthoc analyses corroborate the role of phosphodiesterase type 5 inhibitors ( PDE5-Is ) in the treatment of men with lower urinary tract symptoms ( LUTS ) associated with benign prostatic enlargement ( BPE ) . OBJECTI... | [
"INTRODUCTION Erectile dysfunction ( ED ) and lower urinary tract symptoms suggestive of benign prostatic hyperplasia ( LUTS/BPH ) are common in aging males and frequently occur together . Tadalafil has demonstrated efficacy in treating both conditions . AIM The study aims to evaluate the efficacy and safety of ... | 4116156e-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND Peripheral arterial disease ( PAD ) causes considerable morbidity and mortality . Hypertension is a risk factor for PAD . Treatment for hypertension must be compatible with the symptoms of PAD . Controversy regarding the effects of beta-adrenoreceptor blockade for hypertension in patients with PAD has le... | [
"CONTEXT Despite evidence of efficacy of antihypertensive agents in treating hypertensive patients , safety and efficacy of antihypertensive agents for coronary artery disease ( CAD ) have been discerned only from subgroup analyses in large trials . OBJECTIVE To compare mortality and morbidity outcomes in ... | 411615aa-06ff-11f0-808a-c43d1ab1c353 |
Cardiovascular disease is a leading cause of morbidity and mortality worldwide , and a key barrier to improved outcomes is medication non-adherence . The aim of this study is to review the role of mobile health ( mHealth ) tools for improving medication adherence in patients with cardiovascular disease . We perform... | [
"AIMS AND OBJECTIVES To compare drug adherence to lipid-lowering therapy among out patients with coronary artery disease who received information via short message service , via short message service and Micro Letter , or via phone only . BACKGROUND Messaging applications and short message service are... | 411615e6-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND Evidence is limited regarding the most effective pharmacological treatment for psychotic depression : combination of an antidepressant plus an antipsychotic , monotherapy with an antidepressant or monotherapy with an antipsychotic . This is an up date of a review first published in 2005 and last up dat... | [
"Major Depression with Psychotic Features ( psychotic depression ) is a common , debilitating psychiatric disease . We hypothesized that mifepristone , a cortisol receptor ( GRII ) antagonist , would significantly reduce psychotic symptoms in psychotic depression . Two hundred fifty-eight patients with psychot... | 41161622-06ff-11f0-808a-c43d1ab1c353 |
OBJECTIVE There is burgeoning interest in augmentation strategies for improving inadequate response to antidepressants . The adjunctive use of st and ardized pharmaceutical- grade nutrients , known as nutraceuticals , has the potential to modulate several neurochemical pathways implicated in depression . While ma... | [
"BACKGROUND Depression is common and the efficacy of antidepressants is suboptimal . High plasma homocysteine has been consistently associated with depression , and treatment with certain B vitamins demonstrably reduces its concentration . AIMS To determine whether vitamins B6 , B12 and folic acid enhance resp... | 4116165e-06ff-11f0-808a-c43d1ab1c353 |
Background Physical activity ( PA ) levels decline as children move into adolescence , with this decline more notable in girls . As a consequence , many young people are failing to meet current PA guidelines . Walking has been a cornerstone of PA promotion in adults and may provide an effective means of inc... | [
"OBJECTIVE To evaluate the effectiveness of a program to increase walking to and from school . DESIGN A cluster r and omised controlled trial . SETTING 24 primary public schools in inner west Sydney , Australia . PARTICIPANTS 1996 students aged 10 - 12 years and their parents . INTERVENTION A two-year mult... | 4116169a-06ff-11f0-808a-c43d1ab1c353 |
AIMS To assess the association between atrial fibrillation ( AF ) and all-cause mortality and implantable cardioverter-defibrillators ( ICDs ) therapies in heart failure ( HF ) patients with reduced ejection fraction and an ICD implanted . METHODS AND RESULTS A systematic MEDLINE search performed from inception... | [
"BACKGROUND Implantable cardioverter defibrillator ( ICD ) implantation is a common approach in patients at high risk of sudden cardiac death . To check for normal function , it is necessary to test the ICD . For this purpose , repetitive induction and termination of ventricular fibrillation by direct current... | 411616d6-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND The use of blended payment schemes in primary care , including the use of financial incentives to directly reward ' performance ' and ' quality ' is increasing in a number of countries . There are many examples in the US , and the Quality and Outcomes Framework ( QoF ) for general practitioners ( GPs )... | [
"PURPOSE Major primary care reforms have been introduced in recent years in the United Kingdom , including financial incentives to improve clinical quality and provide more rapid access to care . Little is known about the impact of these changes on patient experience . We examine patient reports of quality of ca... | 41161712-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND Hypovitaminosis D is considered a global public health issue . Knowledge of its true dimensions will allow us to design interventions and plan preventive measures that can have a significant impact on human health . OBJECTIVES The aim of this study was to evaluate the prevalence of hypovitaminosis D , de... | [
"OBJECTIVE To assess the serum level of 25 hydroxyvitamin D 25OHD among healthy Saudi Arabian women living in the eastern province . METHODS A cross-sectional r and omized study was conducted between February 1st 2008 and May 31st 2008 at the King Fahd University Hospital , Al-Khobar , Kingdom of Saudi Ara... | 4116174e-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND AND PURPOSE The association between excessive early migration of acetabular cups and late aseptic revision has been scantily reported . We therefore performed 2 parallel systematic review s and meta-analyses to determine the association between early migration of acetabular cups and late aseptic re... | [
"The effect of bone cement viscosity and cement mantle thickness on the migration of the Exeter total hip prosthesis was studied in a prospect i ve , r and omized , double-blind clinical Roentgen Stereophotogrammetric Analysis study . Forty-one cemented total hip arthroplasty in 39 patients were included an... | 4116178a-06ff-11f0-808a-c43d1ab1c353 |
Existing evidence on the possible effects of synbiotics on lipid profile is inconclusive . The aim of the present systematic review was to clarify the effects of synbiotics consumption on lipid profile . A systematic literature search of online data bases PubMed , Scopus , ISI Web of science , Cochrane 's libra... | [
"Background The prevalent raise of type 2 diabetes ( T2D ) around the globe , are creating higher risk for cardiovascular diseases ( CVDs ) and increasing strain on each country ’s health care budget in the world . Microalbuminuria has appeared as a key parameter in diabetic patients . Microalbuminuria is also ... | 411617c6-06ff-11f0-808a-c43d1ab1c353 |
Abstract A systematic review of the Bristol‐Myers Squibb normal healthy volunteers ( NHVs ) data base identified phase 1 trials that included NHVs administered placebo with the aim of characterizing normal inter‐ and intraindividual safety parameter variability . Twenty‐five single and multiple ascending dose studi... | [
"Objective : The first goal of phase I drug development is the determination of maximal tolerated dose , which must be established by case-by-case analysis , sometimes using a laboratory adverse event . Since no accurate rule defining lab adverse events , has been vali date d yet , we propose a new “ combined me... | 41161802-06ff-11f0-808a-c43d1ab1c353 |
Background The purpose of this systematic review was to accurately assess the procedural success of ridge preservation technique through the application of strict inclusion and exclusion criteria . Data Sources A method ical search of PubMed of the US National Library of Medicine and the Cochrane Central Register o... | [
"BACKGROUND Extraction socket remodeling and ridge preservation strategies have been extensively explored . PURPOSE To evaluate the efficacy of applying a micro-titanium stent as a pressure bearing device on extraction socket remodeling of maxillary anterior tooth . MATERIAL S AND METHODS Twenty-four patients ... | 4116183e-06ff-11f0-808a-c43d1ab1c353 |
Objective : A systematic literature review and meta- analysis on the effectiveness of lifestyle restrictions and pre caution s to prevent dislocation after total hip arthroplasty . Data sources : MEDLINE and the Cochrane Library were search ed in February 2015 , with additional h and search ing of systematic review... | [
"The two senior authors ( PMP , RP ) independently began using an identical enhanced posterior soft tissue repair after total hip replacement through a posterior approach . In the first author 's experience , a dislocation rate of 4 % in 395 patients before using the enhanced closure was reduced to 0 ... | 4116187a-06ff-11f0-808a-c43d1ab1c353 |
Background There is currently no systematic review examining the effects of vitamin D supplementation among athletes . A rigorous systematic review and meta- analysis is important to provide a balanced view of current knowledge on the effect of vitamin D on serum 25-hydroxyvitamin D [ 25(OH)D ] concentrations a... | [
"Calcium and vitamin D are essential nutrients for bone health . Periods of activity with repetitive mechanical loading , such as military training , may result in increases in parathyroid hormone ( PTH ) , a key regulator of Ca metabolism , and may be linked to the development of stress fractures . Previous stud... | 411618b6-06ff-11f0-808a-c43d1ab1c353 |
The purpose of this systematic review and meta- analysis was to investigate omega-3 fatty acids ’ influence on 12 inflammatory biomarkers — LDL , HDL , total cholesterol , TG , HbA1c , Apo AI , Apo AII , Apo B , CRP , TNF-α , glucose , and fasting blood glucose among diabetic and cardiovascular disease ( CVD ) pat... | [
"BACKGROUND AND AIMS Cardiovascular diseases are the major cause of mortality among diabetic patients . The concentration of malondialdehyde ( MDA ) and homocysteine is believed to play a role in cardiovascular diseases . Omega-3 fatty acid supplementation could be effective in some diabetes complications and i... | 411618f2-06ff-11f0-808a-c43d1ab1c353 |
Phosphodiesterase type-5 inhibitors ( PDE5-Is ) have been recommended as first line therapy for erectile dysfunction for patients received nerve-sparing radical prostatectomy for prostate cancer . We examed the efficiency of PDE5-Is and considered the optimal application . Systematic search of PubMed , Embase and... | [
"Purpose . To compare erectile function ( EF ) recovery of patients treated by early penile rehabilitation therapy ( PRT ) with sildenafil and with control group . Method . Forty men treated by bilateral nerve sparing radical prostatectomy ( NSRP ) and with a normal pre-operative EF were enrolled . Fo... | 4116192e-06ff-11f0-808a-c43d1ab1c353 |
OBJECTIVE To quantify the overall effects of bariatric surgery compared with non-surgical treatment for obesity . DESIGN Systematic review and meta- analysis based on a r and om effects model . DATA SOURCES Search es of Medline , Embase , and the Cochrane Library from their inception to December 2012 regardless o... | [
"Background The heterogeneity statistic I2 , interpreted as the percentage of variability due to heterogeneity between studies rather than sampling error , depends on precision , that is , the size of the studies included . Methods Based on a real meta- analysis , we simulate artificially ' inflating ' the sample... | 4116196a-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND : Currently , there is no evidence -based definition for concussion that is being uniformly applied in clinical and research setting s. OBJECTIVE : To conduct a systematic review of the highest- quality literature about concussion and to assemble evidence about the prevalence and associations of key indicato... | [
"Background Neurocognitive testing has been endorsed as a “ cornerstone ’ of concussion management by recent Vienna and Prague meetings of the Concussion in Sport Group . Neurocognitive testing is important given the potential unreliability of athlete self-report after injury . Relying only on athletes'ormalities... | 411619a6-06ff-11f0-808a-c43d1ab1c353 |
Rapid tranquilization is an intervention used in control of agitation or aggression in patients with mental disorders . This study synthesized the available evidence regarding efficacy and safety of drugs used for rapid tranquilization in psychiatric patients with psychomotor agitation . It is an overview study... | [
"OBJECTIVE The authors examined the efficacy of intramuscular flunitrazepam compared with intramuscular haloperidol for the immediate control of agitated or aggressive behavior in acutely psychotic patients . METHOD Twenty-eight actively psychotic in patients , aged 20 - 60 years , who were under treatment... | 411619e2-06ff-11f0-808a-c43d1ab1c353 |
OBJECTIVE : To review the current status of antibiotic prophylaxis for cesarean delivery , emerging strategies to enhance the effectiveness of antibiotic prophylaxis in reducing postcesarean infection , and the implication s of the emerging practice s. DATA SOURCES : We conducted a full PubMed ( January 1966... | [
"OBJECTIVE The purpose of this prospect i ve study was to determine whether the timing of prophylactic antibiotics at cesarean delivery influences maternal/neonatal infectious morbidity . STUDY DESIGN In this double-blind placebo-controlled trial , cefazolin was given at skin incision ( group A ) or at... | 41161a96-06ff-11f0-808a-c43d1ab1c353 |
Anxiety is a common problem in children and adolescents with autism spectrum disorder ( ASD ) . This meta- analysis aim ed to systematic ally evaluate the evidence for the use of psychosocial interventions to manage anxiety in this population . Cognitive behavioural therapy ( CBT ) was the primary intervention ... | [
"Aim : To investigate the acceptability and feasibility of adapted group therapy for anxiety in children with autism spectrum disorder in a pilot r and omised controlled trial . Method : A total of 32 children aged 9–13 years were r and omised to immediate or delayed therapy using the ‘ Exploring Feeling... | 41161adc-06ff-11f0-808a-c43d1ab1c353 |
Dual-task interference during walking can substantially limit mobility and increase the risk of falls among community-dwelling older adults . Previous systematic review s examining intervention effects on dual-task gait and mobility have not assessed relative dual-task costs ( DTC ) or investigated whether ... | [
"PURPOSE OF THE STUDY Older adults ' gait is disturbed when a dem and ing secondary cognitive task is added . Gait training has been shown to improve older adults ' walking performance , but it is not clear how training affects their cognitive performance . This study examined the impact on gait , in terms of... | 41161b18-06ff-11f0-808a-c43d1ab1c353 |
Results of recent studies suggest that circulating levels of vitamin D may play an important role in cancer-specific outcomes . The present systematic review was undertaken to determine the prevalence of vitamin D deficiency ( and to evaluate the association between circulating calcidiol ( the indicator of vita... | [
"BACKGROUND The purpose of this study was to describe bone status in a large cohort of postmenopausal women with nonmetastatic breast cancer , at the initiation of aromatase inhibitor therapy . PATIENTS AND METHODS A prospect i ve , transversal and clinical study was conducted . Each woman had an extensive m... | 41161b54-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND Type 2 diabetes is a significant public health concern . With the completion of the Diabetes Prevention Program , there has been a proliferation of studies attempting to translate this evidence base into practice . However , the cost , effectiveness , and cost-effectiveness of these adapted interventions... | [
"Abstract Background Diabetes prevalence is increasing . The Finnish Diabetes Prevention Study ( DPS ) showed a 58 % reduction in Type 2 Diabetes ( T2D ) incidence in adults with impaired glucose tolerance ( IGT ) . The European Diabetes Prevention Study ( EDIPS ) extends the DPS to different European populatio... | 41161b9a-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND Several clinical trials of vitamin D to prevent asthma exacerbation and improve asthma control have been conducted in children and adults , but a meta- analysis restricted to double-blind , r and omised , placebo-controlled trials of this intervention is lacking . OBJECTIVES To evaluate the eff... | [
"BACKGROUND Low serum 25-hydroxyvitamin D ( 25-[OH]D ) levels have been associated with lower FEV(1 ) , impaired immunologic control , and increased airway inflammation . Because many patients with chronic obstructive pulmonary disease ( COPD ) have vitamin D deficiency , effects of vitamin D supplementation ... | 41161be0-06ff-11f0-808a-c43d1ab1c353 |
Study Design . A systematic review and meta- analysis . Objective . To assess the measurement properties of the Functional Rating Index ( FRI ) and determine whether its measurement properties are comparable with other region-specific question naires . Summary of Background Data . In addition to low back pain ( LBP... | [
"The purpose of the present study was to determine the reliability and validity of the Functional Rating Index ( FRI ) for athletes with low back pain ( LBP ) . In this cross-sectional and prospect i ve cohort study , the vali date d Persian FRI ( PFRI ) was tested in 100 athletes with LBP and 50 healthy athle... | 41161c1c-06ff-11f0-808a-c43d1ab1c353 |
Background Retirement represents a major transitional life stage in middle to older age . Changes in physical activity typically accompany this transition , which has significant consequences for health and well-being . The aim of this systematic review was to evaluate the evidence for the effect of interventions ... | [
"Background The increased prevalence of overweight and obesity warrants preventive actions , particularly among people in transitional stages associated with lifestyle changes , such as occupational retirement . The purpose is to investigate the effect of a one year low-intensity computer-tailored energy balan... | 41161c58-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND Although ventricular tachycardia ( VT ) ablation is a widely used therapy for patients with VT , the ideal end points for this procedure are not well defined . We performed a meta- analysis of the published literature to assess the predictive value of noninducibility of postinfa rct ion VT for long-term ... | [
"Background — Catheter ablation of ventricular tachycardia ( VT ) is effective and particularly useful in patients with frequent defibrillator interventions . Various substrate modification techniques have been described for unmappable or hemodynamically intolerable VT . Noninducibility is the most frequently... | 41161c94-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND Atrial fibrillation ( AF ) is the most common cardiac arrhythmia seen in cardiovascular departments . Treatments include medical interventions and catheter ablation . Due to uncertainties in medical therapies for AF , and the need to continue sinus rhythm , ablation has been recently considered as a viab... | [
"Background —In patients with paroxysmal atrial fibrillation ( AF ) , catheter ablation maintains sinus rhythm more effectively than antiarrhythmic drugs ( AADs ) , but its effect on symptoms and quality of life ( QOL ) has not been fully characterized . Methods and Results —We evaluated symptoms and QOL ... | 41161cd0-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND The prevalence of varicoceles is as high as 15 % in children and adolescents . Optimal management of varicoceles has not been consoli date d. Options include observation , radiological intervention , or surgical varicocelectomy . OBJECTIVE Herein , we aim to assess the outcomes of radiological and sur... | [
"OBJECTIVE To study the effects of varicocele treatment on testicular function in adolescents . DESIGN A prospect i ve controlled study in 88 r and omly selected adolescents . SETTING All participants were referred to the fertility outpatient clinic of our university hospital . PARTICIPANTS All participa... | 41161d16-06ff-11f0-808a-c43d1ab1c353 |
Established primary prevention strategies of cardiovascular diseases are based on underst and ing of risk factors , but whether the same risk factors are associated with atrial fibrillation ( AF ) remains unclear . We conducted a systematic review and field synopsis of the associations of 23 cardiovascular risk ... | [
"Background — Physical activity ( PA ) is well known to reduce the risk of cardiovascular disease . We hypothesized that regular PA , possibly acting through reductions in blood pressure and body mass index ( BMI ) , would reduce the risk of incident atrial fibrillation ( AF ) in women . Methods and Results... | 41161d52-06ff-11f0-808a-c43d1ab1c353 |
Current recommendations for the prevention of type 2 diabetes advise modification of diet and exercise behaviors including both aerobic and resistance training . However , the efficacy of multi-component interventions involving a combination of these three components has not been established . The aims of this ... | [
"BACKGROUND The role of weight training in the primary prevention of type 2 diabetes mellitus ( T2DM ) is largely unknown . METHODS To examine the association of weight training with risk of T2DM in US men and to assess the influence of combining weight training and aerobic exercise , we performed a ... | 41161d8e-06ff-11f0-808a-c43d1ab1c353 |
OBJECTIVE The objective of this article was to present a methodology incorporating existing guidelines and tools for systematic review s and to evaluate the Delphi survey 33 key component recommendations of yoga interventions for musculoskeletal conditions as a tool for a systematic review in fibromyalgia studies . ... | [
"Background : Exercise can be beneficial for cardiopulmonary , musculoskeletal or neurological systems , and other factors including mood , and may be beneficial in reducing fall risks , dementia and variables associated with quality of life ( QOL ) . Parkinson 's disease ( PD ) produces progressive motor and... | 41161dca-06ff-11f0-808a-c43d1ab1c353 |
Although arousal mechanisms have frequently been found to be atypical in ADHD , these findings usually emerged from indirect behavioural measures which give only a limited underst and ing of arousal dysregulation in this condition . To assess the hypothesis that functioning of the autonomic nervous system ( ANS ) , one... | [
"Background Children with attention deficit hyperactivity disorder ( ADHD ) are characterised by developmentally inappropriate levels of hyperactivity , impulsivity and /or inattention and are particularly impaired when performing tasks that require a high level of cognitive control . Methylpheni date ( MPH ) an... | 41161e06-06ff-11f0-808a-c43d1ab1c353 |
Background This article constitutes a partial up date of the original systematic review evidence by Yengopal et al. from 15 January 2008 ( published in the Journal of Oral Science in 2009 ) with primary focus on research quality in regard to bias risk in trials . Its aim is to up date the existing systematic review evi... | [
"To comprehend the results of a r and omised controlled trial ( RCT ) , readers must underst and its design , conduct , analysis , and interpretation . That goal can be achieved only through total transparency from authors . Despite several decades of educational efforts , the reporting of RCTs needs improvement ... | 41161e42-06ff-11f0-808a-c43d1ab1c353 |
Objectives The purpose of this systematic review was to compare the clinical performance of bulk-fill resin composites with conventional resin composites used for direct restorations of posterior teeth . Methods This review followed the PRISMA statement . This review was registered at PROSPERO ( registration number... | [
"Background : The evidence stemming from trials on restorative material s is shaped not only by trial findings , but also trial design and validity . We aim ed to evaluate both aspects in r and omized controlled dental restorative trials published from 2005–2015 . Methods : Using systematic review methodology , w... | 41161e7e-06ff-11f0-808a-c43d1ab1c353 |
Long-Acting Injectable Antipsychotics ( LAIs ) are used to overcome non-compliance in psychoses , mainly schizophrenia spectrum disorders . We aim ed to summarize available evidence of studies comparing the efficacy of LAIs to placebo or oral medications for Bipolar Disorder ( BD ) and /or Schizoaffective Diso... | [
"The number of published systematic review s of studies of healthcare interventions has increased rapidly and these are used extensively for clinical and policy decisions . Systematic review s are subject to a range of biases and increasingly include non-r and omised studies of interventions . It is important tha... | 41161eba-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND The perimenopausal and postmenopausal periods are associated with many symptoms , including sexual complaints . OBJECTIVES To assess the effect of hormone therapy ( HT ) on sexual function in perimenopausal and postmenopausal women . SEARCH METHODS We search ed for articles in the Cochrane Menstrual D... | [
"BACKGROUND tibolone at usual doses of 2.5 mg/day in postmenopausal women has been shown to improve climacteric complaints , without affecting endometrial thickness and lipid profile or blood glucose . However , the potentially similar efficacy , but better tolerability , of a low dose of this drug ... | 41161ef6-06ff-11f0-808a-c43d1ab1c353 |
Introduction There is little epidemiological evidence and knowledge about at-risk alcohol use among community-dwelling older adults and their chronic and acute alcohol-related comorbidities of interest . This systematic review will summarise and examine relevant studies about the epidemiology of at-risk alcohol us... | [
"BACKGROUND Very little work on alcohol consumption patterns in older people has been undertaken . As a result , knowledge about the prevalence and characteristics of regular drinkers and heavy drinkers in this age group remains limited . OBJECTIVE To determine the socio-economic and health characteristics as... | 41161f32-06ff-11f0-808a-c43d1ab1c353 |
Context The aim of this systematic review was to evaluate clinical trial data regarding the effect of resveratrol supplementation on cognitive performance and mood in population s that are healthy and in the clinical setting . Data Sources Using the Preferred Reporting Items for Systematic Review s and Meta-Analy... | [
"Although resveratrol has widely been studied for its potential health benefits , little is known about its metabolic effects in humans . Our aims were to determine whether the polyphenol resveratrol improves insulin sensitivity in type 2 diabetic patients and to gain some insight into the mechanism of its ... | 41161f6e-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND Antihypertensives , such as beta-blockers , are used for pregnancy hypertension in the belief these will improve outcome for mother and baby . OBJECTIVES To assess whether oral beta-blockers are better than placebo , or no beta-blocker , and have advantages over other antihypertensives , for women... | [
"OBJECTIVE --To compare the effects of uteroplacental circulation of two beta adrenoceptor blockers , atenolol ( cardioselective ) and pindolol ( non-selective with intrinsic sympathomimetic activity ) . DESIGN --Controlled double blind double dummy study . SETTING --Departments of obstetrics and gynaecology i... | 41161faa-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND Iron deficiency is one of the most common nutritional deficiencies , and has a number of physiological manifestations . Early , or non-anaemic iron deficiency can result in fatigue and diminished exercise capacity . Oral iron preparations have a high incidence of intolerable side effects , and are ineffect... | [
"Aim The aim of this study was to evaluate the benefits and safety of long-term i.v . iron therapy in iron-deficient patients with heart failure ( HF ) . Methods and results CONFIRM-HF was a multi-centre , double-blind , placebo-controlled trial that enrolled 304 ambulatory symptomatic HF patients with left ... | 41161ff0-06ff-11f0-808a-c43d1ab1c353 |
Health resort medicine ( HRM ; in German : Kurortmedizin ) is a field of medicine with long-lasting tradition in several European countries . A number of systematic review s have shown the effectiveness of HRM in musculoskeletal conditions . Review s focusing on the effectiveness of HRM in non-musculoskeletal... | [
"AIMS Hydrotherapy , i.e. exercise in warm water , as a rehabilitation program has been considered potentially dangerous in patients with chronic heart failure ( CHF ) due to the increased venous return caused by the hydrostatic pressure . However , hydrotherapy has advantages compared to conventional trainin... | 4116202c-06ff-11f0-808a-c43d1ab1c353 |
Background Atrial fibrillation ( AF ) among patients with heart failure with reduced ejection fraction ( HFrEF ) is associated with adverse clinical outcomes . Our primary aim was to evaluate patient-centered outcomes and surrogate outcomes following catheter ablation ( CA ) of AF among patients with HFrEF c... | [
"BACKGROUND Atrial fibrillation ( AF ) and left ventricular systolic dysfunction ( LVSD ) frequently co-exist despite adequate rate control . Existing r and omized studies of AF and LVSD of varying etiologies have reported modest benefits with a rhythm control strategy . OBJECTIVES The goal of this study was to... | 41162068-06ff-11f0-808a-c43d1ab1c353 |
Abstract : The 2014 United States Preventive Services Task Force systematic review found abdominal aortic aneurysm ( AAA ) screening decreased related mortality by close to half . Despite the simplicity of screening , research suggests poor adherence to the recommended AAA screening guidelines . Using the quality imp... | [
"Context Is it cost-effective to screen older adults for abdominal aortic aneurysm ( AAA ) ? Contribution This 7-year follow-up report of a large r and omized trial in the United Kingdom found that men age 65 to 74 years who were invited to have ultrasonography and surveillance for AAA had lower mortality ... | 411620a4-06ff-11f0-808a-c43d1ab1c353 |
BACKGROUND The rising prevalence of autism spectrum disorders ( ASD ) increases the need for evidence -based behavioral treatments to lessen the impact of symptoms on children 's functioning . At present , there are no curative or psychopharmacological therapies to effectively treat all symptoms of the disorders . Ear... | [
"This study extends findings on the effects of intensive applied behavior analytic treatment for children with autism who began treatment at a mean age of 5.5 years . The behavioral treatment group ( n = 13 , 8 boys ) was compared to an eclectic treatment group ( n = 12 , 11 boys ) . Assignment to group... | 411620e0-06ff-11f0-808a-c43d1ab1c353 |
Objective : The aim of this study was to identify , retrieve , critically appraise and synthesize information regarding existing mobile phone text messaging interventions that have been done for secondary prevention of cardiovascular disease ( CVD ) . Methods : A systematic review was conducted . The search ing was... | [
"Flaws in the design , conduct , analysis , and reporting of r and omised trials can cause the effect of an intervention to be underestimated or overestimated . The Cochrane Collaboration ’s tool for assessing risk of bias aims to make the process clearer and more",
"Background The effectiveness of mobile tech... | 4116211c-06ff-11f0-808a-c43d1ab1c353 |
Background Young children appear to spend large portions of their waking time being sedentary . Underst and ing the correlates of sedentary time would assist in developing effective interventions among young children . The purpose of this systematic review was to summarise the current literature on the correlates o... | [
"Background Little is known about preschool-aged children ’s levels of physical activity ( PA ) over the course of the day . Using time-stamped data , we describe the levels and patterns of PA in a population -based sample of four-year-old British children . Methods Within the Southampton Women ’s Survey ... | 41162158-06ff-11f0-808a-c43d1ab1c353 |
Abstract To estimate the associations between vitamin D status and Parkinson ’s disease ( PD ) . We search ed electronic data bases of the human literature in PubMed , EMBASE and the Cochrane Library up to February , 2014 using the following keywords : ‘ vitamin D ’ or ‘ 25(OH)D ’ and ‘ status ’ or ‘ deficiency ’... | [
"BACKGROUND A role for vitamin D deficiency in Parkinson disease ( PD ) has recently been proposed . OBJECTIVE To compare the prevalence of vitamin D deficiency in a research data base cohort of patients with PD with the prevalence in age-matched healthy controls and patients with Alzheimer disease ( AD ) . ... | 41162194-06ff-11f0-808a-c43d1ab1c353 |
The serious health , social and economic consequences of falls are well documented . Lower extremity muscle weakness and power as well as balance impairment are major independent intrinsic contributors to falls and amenable to intervention . Progressive resistance training ( PRT ) is widely accepted as an appropriate... | [
"We investigated factors associated with falls in a community-based prospect i ve study of 761 subjects 70 years and older . The group experienced 507 falls during the year of monitoring . On entry to the study a number of variables had been assessed in each subject . Variables associated with an increased ... | 411621d0-06ff-11f0-808a-c43d1ab1c353 |
Background The primary aim of this review study was to gather evidence on the effectiveness in terms of return to work ( RTW ) of occupational therapy interventions ( OTIs ) in rehabilitation patients with non-congenital disorders . A secondary aim was to be able to select the most efficient OTI . Methods A sys... | [
"UNLABELLED Chronic diseases of the musculoskeletal system rank first as causes of early retirement in Germany . Therefore orthopaedic rehabilitation has to identify patients with work-related problems and to promote return to work through differential treatment and vocational counselling . In the framework... | 4116220c-06ff-11f0-808a-c43d1ab1c353 |
Background Psychiatric patients have more physical health problems and much shorter life expectancies compared to the general population , due primarily to premature cardiovascular disease . A multi-causal model which includes a higher prevalence of risk factors has provided a valid explanation . It takes into consid... | [
"While weight-management interventions are effective in attenuating antipsychotic-induced weight , there is no available evidence on their long-term effectiveness . This study sought to investigate the 2-year effects of an early behavioural intervention ( EBI ) design ed to prevent antipsychotic-induced weig... | 41162248-06ff-11f0-808a-c43d1ab1c353 |
Purpose To identify vision Patient-Reported Outcomes instruments relevant to glaucoma and assess their content validity . Methods MEDLINE , MEDLINE in Process , EMBASE and SCOPUS ( to January 2009 ) were systematic ally search ed . Observational studies or r and omised controlled trials , published in English ,... | [
"PURPOSE The Comparison of Ophthalmic Medications for Tolerability ( COMTOL ) question naire was developed for use in clinical trials to compare the tolerability of topical ophthalmic medications used in the treatment of glaucoma . The question naire captures the frequency and bother of common side effects ( ... | 41162284-06ff-11f0-808a-c43d1ab1c353 |
CONTEXT Moderate-to-vigorous physical activity ( MVPA ) and sedentary time ( ST ) are important for child and adolescent health . OBJECTIVE To examine habitual levels of accelerometer measured MVPA and ST in children and adolescents with chronic disease , and how these levels compare with healthy peers . ... | [
"The purpose s of this study were to : 1 ) describe the patterns of screen-based sedentary behaviors , and 2 ) examine the association between screen-based sedentary behavior and cardiovascular disease ( CVD ) risk factors in representative Korean children and adolescents , aged 12 to 18 yr , in the Korean N... | 411622ca-06ff-11f0-808a-c43d1ab1c353 |
Research has shown that people who have rheumatoid arthritis ( RA ) do not usually participate in enough physical activity to obtain the benefits of optimal physical activity levels , including quality of life , aerobic fitness and disease-related characteristics . Behaviour change theory underpins the promotion of p... | [
"OBJECTIVE To determine geographical variation in the prevalence of rheumatoid arthritis ( RA ) and spondyloarthropathies ( SpA ) in France . METHODS The survey sample was drawn from 7 areas of France . Households were r and omly selected using the national telephone directory , and an individual within each ... | 41162306-06ff-11f0-808a-c43d1ab1c353 |
OBJECTIVE To describe the pain decrease considered as clinical ly relevant when design ing a trial and reporting its results . METHODS A systematic review of the literature in MEDLINE was conducted to select r and omized controlled trials ( RCTs ) with pain as a primary outcome . Data extracted included the def... | [
"BACKGROUND Autologous bone graft is the so-called gold st and ard for reconstruction of bone defects and nonunions . The most frequent complication is donor site pain . The iliac crest is a common source for autologous bone graft . The purpose of this study was to determine whether a continuous infusion of 0.5... | 41162342-06ff-11f0-808a-c43d1ab1c353 |
PURPOSE The concept of biologic width forms a basis for successful peri-implant soft tissue integration around titanium implants . Therefore , the objectives of this review are to determine and critically evaluate the present knowledge about biologic width around implants and to establish future research trends . M... | [
"The aim of this study of the present experiment was to study the marginal periimplant tissues at intentionally non-submerged ( 1-stage implants ) and initially submerged and subsequently exposed implants ( 2-stage implants ) . 5 beagle dogs , about 1-year-old , were used , 3 months after the extraction of t... | 4116237e-06ff-11f0-808a-c43d1ab1c353 |
Background In childhood , attention deficit/hyperactivity disorder ( ADHD ) is characterized by age-inappropriate levels of inattentiveness/disorganization , hyperactivity/impulsiveness , or a combination thereof . Although the criteria for ADHD are well defined , the long-term consequences in adults and children need ... | [
"There is increased global recognition of attention deficit hyperactivity disorder ( ADHD ) as a serious medical condition with long-term consequences . Although originally conceived of as a childhood disorder , ADHD is being increasingly recognized in adults . Individual geographic regions may have specific intere... | 411623ba-06ff-11f0-808a-c43d1ab1c353 |
Background Various clinical trials suggested that risperidone was beneficial in the treatment of autism spectrum disorder ( ASD ) in children and adolescents . Objective The aim of this systematic review was to determine the efficacy , acceptability and tolerability of risperidone in the treatment of children ... | [
"OBJECTIVE Impairments associated with attention-deficit/hyperactivity disorder ( ADHD ) and noncompliance are prevalent in children with autism spectrum disorder ( ASD ) . However , ADHD response to stimulants is well below rates in typically developing children , with frequent side effects . Group studies of tr... | 411623f6-06ff-11f0-808a-c43d1ab1c353 |
Background Iron deficiency is very common in a number of medical conditions . Ferric carboxymaltose is a new stable iron preparation that can be administered in single infusions over short periods of time . The aim of this study was to conduct a systematic review of r and omised controlled trials ( RCTs ) regarding... | [
"BACKGROUND Iron-deficiency anemia in non-dialysis-dependent chronic kidney disease ( NDD-CKD ) frequently requires parenteral iron replacement , but existing therapies often require multiple administrations . We evaluated the efficacy and cardiovascular safety of ferric carboxymaltose ( FCM ) , a non-de... | 41162432-06ff-11f0-808a-c43d1ab1c353 |
AIMS To conduct a systematic review and meta- analysis of relevant r and omized clinical trials ( RCTs ) to ascertain the effect size of orlistat in modulating plasma levels of adipokines , ghrelin and C-reactive protein ( CRP ) . METHODS Medline , SCOPUS , Web of Science and Google Scholar data bases were search... | [
"OBJECTIVE The aim of this study was to evaluate the levels of adipose tissue related hormones , cytokines , and antioxidative substances in obese women before and after intervention with diet alone or with diet plus an inhibitor of gastrointestinental lipase-orlistat . DESIGN Seventy-one obese women of ch... | 4116246e-06ff-11f0-808a-c43d1ab1c353 |
Background Robotic-assisted total hip arthroplasty ( THA ) allows for accurate preoperative planning and component positioning , potentially enhancing implant survival and long-term outcomes . The relative efficacy and safety of robotic-assisted and conventional THA , however , are unclear . This systematic review ... | [
"Background Late infection is the second most frequent early complication after total hip arthroplasty ( THA ) and the most frequent after hemiarthroplasty . Known risk factors for infection after THA include posttraumatic osteoarthritis , previous surgery , chronic liver disease , corticoid therapy , and e... | 411624aa-06ff-11f0-808a-c43d1ab1c353 |
INTRODUCTION In an accompanying study we reported on the content of several activity rating scales that have been used for muscle disease . To further aid in achieving consensus we conducted a systematic review to assess the quality of the 19 activity rating scales design ed specifically for muscle disease . ... | [
"The natural history of mitochondrial diseases is poorly understood , limiting our ability to offer prognostic advice to patients or to evaluate therapy . One major obstacle to improving our underst and ing is the lack of a clinical rating scale to monitor the extensive clinical spectrum of mitochondrial disease . ... | 411624e6-06ff-11f0-808a-c43d1ab1c353 |
Background : No studies have been published on an astronaut population to assess the effectiveness of counter measures for limiting physiological changes in the lumbopelvic region caused by microgravity exposure during spaceflight . However , several studies in this area have been done using spaceflight simulati... | [
"Astronauts experience spine deconditioning during exposure to microgravity due to the lack of axial loads on the spine . Treadmill exercise in a lower body negative pressure ( LBNP ) chamber provides axial loads on the lumbar spine . We hypothesize that daily supine LBNP exercise helps counteract lumbar... | 41162522-06ff-11f0-808a-c43d1ab1c353 |
Background . The goal of this systematic review is to determine the most commonly used outcome measurement tools used by foot and ankle specialists and determine their limitations , such as whether they are vali date d , have floor/ceiling effects , and so on . Methods . A literature search was conducted to identif... | [
"BACKGROUND Many PROMs used for evaluation of ankle osteoarthritis are not vali date d for this purpose . We hypothesize that frequently used PROMs have an early ceiling or floor effect . METHODS We prospect ively collected data from patients with ankle osteoarthritis between 2011 and 2013 . At baseline visit... | 4116255e-06ff-11f0-808a-c43d1ab1c353 |
AIM To examine current evidence on use of active video gaming ( AVG ) to improve motor function in children with movement disorders including cerebral palsy , developmental coordination disorder , and Down syndrome . METHOD Scopus , MEDLINE , Cochrane Library , EMBASE , and CINAHL were search ed . Included papers... | [
"BACKGROUND Impaired motor development can significantly affect a child 's life and may result in an increased risk of a range of physical and psychological disorders . Active video game ( AVG ) interventions have been demonstrated to enhance motor skills in children with Developmental Coordination Disorder ( ... | 4116259a-06ff-11f0-808a-c43d1ab1c353 |
Modafinil is a central nervous system wake promoting agent used for the treatment of excessive daytime sleeping . Its vigilance promoting properties and low abuse potential has intrigued the scientific community and has led to use it as a cognitive enhancer , before its neural functions were understood . Here , we revi... | [
"Background Selective serotonin reuptake inhibitors ( SSRIs ) are typically thought to have a delay of several weeks in the onset of their clinical effects . However , recent reports suggest they may have a much earlier therapeutic onset . A reduction in amygdala responsivity has been implicated in the therapeu... | 411625d6-06ff-11f0-808a-c43d1ab1c353 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.