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In the large-scale trials carried out in Tanganyika and described in this paper , such a combination , containing amodiaquine for schizontocidal effect and primaquine as a gametocytocide , was administered to three distinct population groups of more than 5000 at differing intervals of time , in order to determine the ability of this combination to interfere with transmission in the absence of other malaria control measures . | [{'class': 'COMB', 'spans': ['amodiaquine', 'primaquine'], 'is_context_needed': True}] |
In transplant eligible patients , induction therapy consists of bortezomib , lenalidomide , dexamethasone ( VRd ) given for approximately 3 - 4 cycles followed by autologous stem cell transplantation ( ASCT ) . | [{'class': 'POS', 'spans': ['bortezomib', 'lenalidomide', 'dexamethasone'], 'is_context_needed': True}] |
Genistein combined polysaccharide enhances activity of docetaxel , bicalutamide and Src kinase inhibition in androgen-dependent and independent prostate cancer cell lines . | [{'class': 'POS', 'spans': ['Genistein', 'docetaxel'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
Combination therapy with bosentan and sildenafil was effective for this case of refractory PAH associated with fibrotic lung in systemic sclerosis . | [{'class': 'POS', 'spans': ['bosentan', 'sildenafil'], 'is_context_needed': False}] |
All patients had received concomitant immunosuppressive medications in addition to infliximab or etanercept , and all resided in HC-endemic regions . | [] |
Analysis of 52 eyes with high-risk retinoblastoma managed with postenucleation adjuvant chemotherapy using vincristine sulfate , etoposide phosphate , and carboplatin showed no evidence of systemic metastasis in any case during a mean ( range ) follow-up of 66 ( 12 - 202 ) months . | [{'class': 'POS', 'spans': ['vincristine', 'etoposide', 'carboplatin'], 'is_context_needed': True}] |
Clinical and cost-effectiveness of capecitabine and tegafur with uracil for the treatment of metastatic colorectal cancer : systematic review and economic evaluation . | [{'class': 'COMB', 'spans': ['capecitabine', 'tegafur'], 'is_context_needed': True}] |
All strains were susceptible to phenoxymethylpenicillin , cephalosporins , erythromycin , azithromycin , clindamycin , vancomycin , doxycycline , and ciprofloxacin but were resistant to trimethoprim-sulfamethoxazole . | [] |
The inhibition by the agonist oxotremorine is comparable to that of carbachol and 1 mM pilocarpine inhibited the binding by 21 % . | [] |
Cost-effectiveness of cetuximab , cetuximab plus irinotecan , and panitumumab for third and further lines of treatment for KRAS wild-type patients with metastatic colorectal cancer . | [{'class': 'POS', 'spans': ['cetuximab', 'irinotecan'], 'is_context_needed': True}] |
Limits of quantification were 0.12 , 1.09 , 1.46 , 1.47 , 5.70 , 1.32 , 1.33 µg/L for haloperidol , aripiprazole , olanzapine , quetiapine , clozapine , risperidone , and paliperidone , respectively . | [] |
Sensitization to doxorubicin and etoposide with BPTF knockdown ( KD ) was associated with increased DNA damage , topoisomerase II ( TOP2 ) crosslinking and autophagy ; however , there was only a modest increase in apoptosis and no increase in senescence . | [] |
This multicenter pilot study assessed the feasibility and efficacy of a time-intensified bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , and prednisone ( BEACOPP ) regimen given in 14-day intervals ( BEACOPP-14 ) with granulocyte colony-stimulating factor ( G-CSF ) support in advanced Hodgkin 's lymphoma . | [{'class': 'POS', 'spans': ['bleomycin', 'etoposide', 'doxorubicin', 'cyclophosphamide', 'vincristine', 'procarbazine', 'prednisone'], 'is_context_needed': True}] |
Safety and efficacy of daclatasvir and asunaprevir in hepatitis C virus-infected patients with renal impairment . | [{'class': 'POS', 'spans': ['daclatasvir', 'asunaprevir'], 'is_context_needed': True}] |
We report the results of replacement of steroids by azathioprine ( AZA ) in 25 primary cadaveric renal transplant recipients initially treated with CsA and methylprednisolone ( MP ) . | [{'class': 'POS', 'spans': ['azathioprine', 'CsA'], 'is_context_needed': True}] |
Median OS was 34.2 and 24.3 months in the panitumumab and bevacizumab arms , respectively ( HR , 0.62 ; 95 % CI , 0.44 to 0.89 ; P = .009 ) . | [] |
One group of patients was treated with oral mefloquine ( 750 mg ) and artemether ( 600 mg by injection , 200 mg initially and 100 mg every 12 h ) . | [{'class': 'POS', 'spans': ['mefloquine', 'artemether'], 'is_context_needed': True}] |
The role of irinotecan and oxaliplatin in the treatment of advanced colorectal cancer . | [{'class': 'POS', 'spans': ['irinotecan', 'oxaliplatin'], 'is_context_needed': True}] |
In both cases , chemotherapy comprising rituximab + dose-adjusted EPOCH regimen ( etoposide , prednisone , vincristine , cyclophosphamide and doxorubicin ) was administered . | [{'class': 'POS', 'spans': ['rituximab', 'etoposide', 'prednisone', 'vincristine', 'cyclophosphamide', 'doxorubicin'], 'is_context_needed': True}] |
Bleeding prophylaxis included combinations of plasma-derived factor ( VWD ) or recombinant factor ( haemophilia A and haemophilia B ) , desmopressin and/or tranexamic acid . | [{'class': 'POS', 'spans': ['desmopressin', 'tranexamic'], 'is_context_needed': True}] |
Although progression-free survival with the bevacizumab plus capecitabine combination is inferior to that noted with bevacizumab plus paclitaxel , we suggest that physicians should consider possible predictive risk factors for overall survival , individual 's treatment priorities , and the differing safety profiles . | [{'class': 'COMB', 'spans': ['bevacizumab', 'capecitabine'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}] |
The combination of ixabepilone and bevacizumab was well tolerated , with modest activity in second - or later-line mRCC , but it is not recommended as a therapy without further clinical development . | [{'class': 'COMB', 'spans': ['ixabepilone', 'bevacizumab'], 'is_context_needed': True}] |
Eligible patients with unresectable MPM , without disease progression following 4 to 6 cycles of pemetrexed and platinum were randomized 1:1 to observation or continuation of pemetrexed until progression , stratified by number of cycles ( < 6 or 6 ) , cis- or carboplatin containing regimen , and histology . | [{'class': 'COMB', 'spans': ['pemetrexed', 'platinum'], 'is_context_needed': True}] |
A Phase II trial reported a median OS duration of 8.6 months for patients receiving cetuximab plus irinotecan , plus a median time to progression of 4.1 months , a tumour response rate of 22.9 % and suggested that treatment with cetuximab in combination with irinotecan is associated with significantly more adverse events ( any grade 3 or grade 4 adverse event ) than cetuximab monotherapy . | [{'class': 'COMB', 'spans': ['cetuximab', 'irinotecan'], 'is_context_needed': True}] |
Our results show meaningful activity of T-DM1 after front-line pertuzumab plus trastuzumab and a taxane , with about 27 % of patients having an objective response and 40 % of patients achieving durable disease control . | [{'class': 'POS', 'spans': ['pertuzumab', 'trastuzumab'], 'is_context_needed': False}] |
Dapagliflozin seemed to play a role in accelerating the patient 's urinary sodium excretion as well as reducing gross fluid retention despite the fact that her nephrotic condition was resistant to furosemide . | [{'class': 'POS', 'spans': ['Dapagliflozin', 'furosemide'], 'is_context_needed': True}] |
PA combination of goserelin and tamoxifen in patients with relapsed ovarian cancer can not be recommended as standard therapy , but may result in long-term survival in individual patients . | [{'class': 'COMB', 'spans': ['goserelin', 'tamoxifen'], 'is_context_needed': True}] |
In previous analyses of the MURANO study , fixed-duration venetoclax plus rituximab ( VenR ) resulted in improved progression-free survival ( PFS ) compared with bendamustine plus rituximab ( BR ) in patients with relapsed or refractory chronic lymphocytic leukemia ( CLL ) . | [{'class': 'POS', 'spans': ['venetoclax', 'rituximab'], 'is_context_needed': False}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}] |
The aim of the present study was to determine whether a combination of atorvastatin and amlodipine causes sympathoinhibition via reduction of oxidative stress in the RVLM and improves cognitive dysfunction of hypertensive rats . | [{'class': 'POS', 'spans': ['atorvastatin', 'amlodipine'], 'is_context_needed': True}] |
Active treatment consisted of hydrochlorothiazide ( 25 - 50 mg/day ) plus triamterene ( 50 - 100 mg/day ) with the addition of alpha-methyldopa ( 0.5 - 2.0 g/day ) in one-third of the patients . | [{'class': 'POS', 'spans': ['hydrochlorothiazide', 'triamterene', 'alpha-methyldopa'], 'is_context_needed': True}] |
Eight days treatment with 15 μM clozapine increased adipogenesis by 37.4 % and 50 μM risperidone increased adipogenesis by 26.5 % during 3T3-L1 cell differentiation accompanied by increased SREBP-1 , PPARγ , C/EBPα , LDLR and Adiponectin gene expression . | [] |
It is predicted that patients suffering from both VL and cardiac disorders ( atrial fibrillation ) may benefit if they are treated with warfarin in conjunction with first-line antileishmanial therapies such as miltefosine and AmBisome . | [{'class': 'COMB', 'spans': ['warfarin', 'miltefosine'], 'is_context_needed': True}] |
If concomitant therapy is absolutely necessary , the dose of digoxin should be halved prior to initiating dronedarone . | [{'class': 'COMB', 'spans': ['digoxin', 'dronedarone'], 'is_context_needed': True}] |
Stable isotope labelling by amino acids in cell culture ( SILAC ) coupled to high-resolution mass spectrometry ( MS ) was implemented to globally characterise cellular protein levels induced by KSR1 in the presence of doxorubicin or etoposide . | [] |
All patients received neoadjuvant chemotherapy with cyclophosphamide , doxorubicin , and fluorouracil , or cyclophosphamide , doxorubicin , vincristine , and prednisone . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'fluorouracil'], 'is_context_needed': True}, {'class': 'POS', 'spans': [3, 4, 5, 6], 'is_context_needed': True}] |
Chemotherapy consisted of ( 1 ) fluorouracil ( 5-FU ) , ( 2 ) 5-FU variations , ( 3 ) 5-FU plus oxaliplatin , ( 4 ) 5-FU plus irinotecan , or ( 5 ) oral fluoropyrimidine-based regimens . | [] |
To evaluate and compare the influences of micronized fenofibrate and atorvastatin on serum lipid profile , including lipoprotein(a ) levels , and on fibrinogen levels in a large group of patients with primary mixed hyperlipidemia ( serum total and low-density lipoprotein cholesterol levels > 240 and 160 mg/dl , respectively , and serum triglyceride level > 200 mg/dl ) . | [] |
Comparison of brimonidine with latanoprost in the adjunctive treatment of glaucoma . ALPHAGAN/XALATAN Study Group . | [] |
Pretreatment with inhaled N(2)O can reduce the pain associated with propofol and rocuronium injection . | [] |
To further these observations , we discovered that the bromodomain PHD finger transcription factor subunit ( BPTF ) of the nucleosome remodeling factor ( NURF ) promotes resistance to doxorubicin , etoposide and paclitaxel in the 4T1 breast tumor cell line . | [] |
We analyzed 129 non-Hodgkin lymphoma patients who underwent AHSCT from 1996 to 2013 using the most common regimens : CBV ( cyclophosphamide , carmustine and etoposide ; n = 16 ) , BEAM ( carmustine , etoposide , cytarabine and melphalan ; n = 36 ) and BEAC ( carmustine , etoposide , cytarabine and cyclophosphamide ; n = 77 ) . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'carmustine', 'etoposide'], 'is_context_needed': True}, {'class': 'POS', 'spans': [3, 4, 5, 6], 'is_context_needed': True}, {'class': 'POS', 'spans': [8, 9, 10, 7], 'is_context_needed': True}] |
Early Prostate-Specific Antigen ( PSA ) Change at Four Weeks of the First-Line Treatment Using Abiraterone and Enzalutamide Could Predict Early/Primary Resistance in Metastatic Castration-Resistant Prostate Cancer . | [{'class': 'POS', 'spans': ['Abiraterone', 'Enzalutamide'], 'is_context_needed': True}] |
Several chemotherapy drugs are active in SCCHN , most notably the platinum compounds , taxanes , fluorouracil ( 5-FU ) , methotrexate and cetuximab . | [] |
Dexamethasone , cytarabine , ifosfamide , and cisplatin as salvage therapy in non-Hodgkin lymphoma . | [{'class': 'POS', 'spans': ['Dexamethasone', 'cytarabine', 'ifosfamide', 'cisplatin'], 'is_context_needed': True}] |
Cost-effectiveness of ribociclib plus letrozole | [{'class': 'POS', 'spans': ['ribociclib', 'letrozole'], 'is_context_needed': True}] |
We investigated whether lapatinib plus gemcitabine has synergistic or antagonistic effects on the pancreatic cancer cell lines MiaPaca-2 and PANC-1 . | [{'class': 'COMB', 'spans': ['lapatinib', 'gemcitabine'], 'is_context_needed': True}] |
Gal(beta1 - 3)Galbeta1-methyl ( disaccharide ) and GalNAc(beta1 - 4)GlcA(beta1 - 3)GalNAc(beta1 - 4 ) GlcA(beta1 - 3)GalNAc(pentasaccharide ) were used respectively as acceptors of [14C]GlcA from UDP-[14C]GlcA. Distributions of the two GlcA transferase activities in the sucrose-density-gradient fractions were compared with each other and with the previously reported distribution of the activities of Gal transferases ( UDP-Gal to ovalbumin , and to xylose of the proteochondroitin linkage region ) and GalNAc ( N-acetylgalactosamine ) transferase II of chondroitin polymerization . | [] |
No significant changes of endothelium-independent dilation were observed with both drugs ( from 17.10+/-2.4 % to 18.14+/-3.76 % and from 18.73+/-4.07 % to 17.46+/-4.27 % during nifedipine and hydrochlorothiazide , respectively , NS ) . | [] |
The PANDORA trial has demonstrated that the combination of high dose pantoprazole with docetaxel is tolerable , but the clinical activity was not sufficient to warrant further testing . | [{'class': 'COMB', 'spans': ['pantoprazole', 'docetaxel'], 'is_context_needed': True}] |
Effective plasma levels of both saquinavir and lopinavir can be achieved by the co-administration of saquinavir soft-gel capsules and lopinavir/ritonavir . | [{'class': 'POS', 'spans': ['saquinavir', 'lopinavir'], 'is_context_needed': True}] |
Clopidogrel administration significantly reduces the likelihood of recurrent CATE compared with aspirin in cats ; both drugs were well tolerated . | [] |
In recent years several tyrosine kinase inhibitors targeting specific molecular pathways involved in its pathogenesis have been investigated , such as sorafenib , lenvatinib , and sunitinib . | [{'class': 'POS', 'spans': ['sorafenib', 'sunitinib'], 'is_context_needed': True}] |
By passage 25 and thereafter , the selected cells were resistant to doxorubicin , etoposide , mitoxantrone and 5-fluorouracil by a pathway that was independent of MDR1 , MRP1 , MRP2 and breast cancer resistance protein . | [] |
The in vitro antibacterial activity of zidovudine alone and in combination with ciprofloxacin was investigated . | [{'class': 'POS', 'spans': ['zidovudine', 'ciprofloxacin'], 'is_context_needed': True}] |
This patient was a case of primary antiphospholipid antibody syndrome in which endothelial cell damage was located exclusively in the capillary lumens and pulse cyclophosphamide therapy in addition to prednisolone and anticoagulant was effective . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'prednisolone'], 'is_context_needed': False}] |
Vancomycin and gentamicin were administered systemically just prior to surgery and streptomycin was added to the irrigating solution . | [{'class': 'POS', 'spans': ['Vancomycin', 'gentamicin', 'streptomycin'], 'is_context_needed': True}] |
We observed a synergistic cytotoxic effect for the combination of foretinib and lapatinib on the viability and proliferation of the examined melanoma cell lines . | [{'class': 'POS', 'spans': ['foretinib', 'lapatinib'], 'is_context_needed': False}] |
Regarding microbiological cure metronidazole therapy was as effective as vancomycin therapy ( RR=0.88 , 95 % CI=0.64 - 1.21 , p=0.43 ) . | [] |
During the infusion protocol used in clinical practice , etoposide , cytarabine and daunorubicine were stable and compatible with the various materials present in the infusion sets and extension tubing ( polyvinyl chloride , polyethylene ) and catheters ( silicone ) . | [] |
Following knockdown of ANXA2 in NB cell line SK-N-BE(2 ) using shRNA , we demonstrate enhanced drug sensitivity for doxorubicin ( 2.77-fold ) and etoposide ( 7.87-fold ) compared with control . | [{'class': 'POS', 'spans': ['doxorubicin', 'etoposide'], 'is_context_needed': False}] |
Combined therapy with amiodarone and carvedilol provided greatest reduction of sudden arrhythmic and total mortality . | [{'class': 'POS', 'spans': ['amiodarone', 'carvedilol'], 'is_context_needed': False}] |
Efficacy of paclitaxel , carboplatin , and bevacizumab for cervical cancer : A protocol for systematic review and meta-analysis . | [] |
The eradication rate of C. trachomatis in baseline-positive patients at the first follow-up visit in the azithromycin group was 96 % with one persistent case , and 100 % in the doxycycline group . | [] |
For example , the overall objective response rate of 9.5 % with single agent sunitinib compares similarly to that of pemetrexed or docetaxel in previously treated NSCLC patients , but toxicity , notably fatigue , lead to discontinuation in 38 % of patients . | [] |
Patients with progressive refractory NSCLC who had previously benefitted from erlotinib ( objective response or stable disease > 8weeks ) were randomized to receive treatment with either erlotinib and sorafenib ( 400 mg orally twice daily ) or sorafenib alone . | [{'class': 'NEG', 'spans': ['erlotinib', 'sorafenib'], 'is_context_needed': True}] |
In this challenging field , aflibercept offers a good option for oxaliplatin-refractory mCRC patients when combined with irinotecan and 5-fluorouracil irrespective of prior anti-angiogenic treatment . | [{'class': 'POS', 'spans': ['aflibercept', 'irinotecan', '5-fluorouracil'], 'is_context_needed': False}] |
The combination of 1-hour paclitaxel , carboplatin , and extended oral schedule etoposide is feasible and well tolerated at the doses administered in this phase II trial . | [{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin', 'etoposide'], 'is_context_needed': False}] |
In this regard , we have synthesized Pem-PEG-Gem , wherein pemetrexed ( Pem ) and gemcitabine ( Gem ) are conjugated to a heterobifunctional polyethylene glycol ( PEG ) polymer for the effective treatment of Non-Small Cell Lung Cancer ( NSCLC ) . | [{'class': 'POS', 'spans': ['pemetrexed', 'gemcitabine'], 'is_context_needed': True}] |
After the initiation of antimalarial treatment with artesunate and mefloquine , his clinical condition gradually improved . | [{'class': 'POS', 'spans': ['artesunate', 'mefloquine'], 'is_context_needed': False}] |
For those few patients who do not respond to first-line therapy , the combination of vinblastine , ifosfamide , and cisplatin is the most popular regimen for the subset of platinum-sensitive tumors . | [{'class': 'POS', 'spans': ['vinblastine', 'ifosfamide', 'cisplatin'], 'is_context_needed': True}] |
Antibiotic treatment was changed to imipenem/cilastatin , piperacillin , gentamicin , clarithromycin , erythromycin , and minocycline . | [] |
Patients received once-daily vandetanib ( planned dosing levels of 100 , 200 , and 300 mg ) with concomitant daily radiotherapy ( 1.8 Gy/d , 45 Gy total ) and chemotherapy , consisting of infusional 5-FU ( 225 mg/m/d over 96 h , weekly ) , paclitaxel ( 50 mg/m , days 1 , 8 , 15 , 22 , 29 ) and carboplatin ( AUC of 5 , days 1 , 29 ) . | [{'class': 'POS', 'spans': ['vandetanib', '5-FU', 'paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
Randomized comparison of tamoxifen and two separate doses of toremifene in postmenopausal patients with metastatic breast cancer . | [] |
Eighteen patients received chemotherapy including etoposide , prednisone , vincristine , cyclophosphamide , and doxorubicin ( n = 13 ) and cyclophosphamide , doxorubicin , vincristine , and prednisone ( n = 2 ) . | [] |
The calcium channel blocker verapamil has been previously shown to augment the chemosensitivity of pancreatic adenocarcinoma cell lines to doxorubicin by mechanisms other than changes in the intracellular accumulation , retention , or metabolism of doxorubicin . | [{'class': 'COMB', 'spans': ['verapamil', 'doxorubicin'], 'is_context_needed': True}] |
The results of a randomized phase II trial have demonstrated that the addition of cetuximab to irinotecan in patients with irinotecan-resistant tumors represents another active treatment option for these patients . | [{'class': 'POS', 'spans': ['cetuximab', 'irinotecan'], 'is_context_needed': False}] |
Normal heart rate and rhythm were then preserved temporarily with digoxin and flecainide . | [{'class': 'POS', 'spans': ['digoxin', 'flecainide'], 'is_context_needed': False}] |
A phase I/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer . | [{'class': 'POS', 'spans': ['irinotecan', 'capecitabine'], 'is_context_needed': True}] |
The purpose of this study was to determine whether combination therapy with vancomycin and TZP is associated with an incidence of AKI in pediatric patients higher than that in those on combination therapy with vancomycin and cefepime . | [{'class': 'NEG', 'spans': ['vancomycin', 'TZP'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
In patients who experience disease progression after etoposide , doxorubicin , cisplatin with mitotane ( EDP-M ) , gemcitabine and metronomic capecitabine , or the less used streptozotocin , represent a second-line chemotherapy option . | [{'class': 'POS', 'spans': ['gemcitabine', 'capecitabine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [4, 6], 'is_context_needed': False}] |
We conclude that ropivacaine alone injected into the pterygomandibular region does not affect the cardiovascular system and that the addition of epinephrine has no beneficial effect . | [{'class': 'COMB', 'spans': ['ropivacaine', 'epinephrine'], 'is_context_needed': True}] |
The next broad-spectrum drug was ethionamide , followed by ansamycin , rifampin , capreomycin , kanamycin , streptomycin and ethambutol . | [{'class': 'COMB', 'spans': ['ethionamide', 'rifampin', 'capreomycin', 'kanamycin', 'streptomycin', 'ethambutol', 'ansamycin'], 'is_context_needed': True}] |
Phase I/II study of gefitinib and capecitabine in patients with colorectal cancer . | [{'class': 'POS', 'spans': ['gefitinib', 'capecitabine'], 'is_context_needed': True}] |
Both the BTK inhibitor ibrutinib and the BCL2 inhibitor venetoclax are active as monotherapy in the treatment of mantle-cell lymphoma . | [{'class': 'POS', 'spans': ['ibrutinib', 'venetoclax'], 'is_context_needed': True}] |
The chloroethylating nitrosoureas ( lomustine , fotemustine , cystemustine ( BCNU ) and methylating agents temozolomide ( TMZ ) , dacarbazine ( DTIC ) , procarbazine ) have documented activity in metastatic malignant melanoma with single agent response rates of 15 - 25 % . | [] |
The population growth rate was adversely influenced by exposure to chlortetracycline , sulfamethazine , or sulfathiazole in water fleas , but reduction in population size was not expected . | [] |
A group of 14 patients with small-cell lung cancer received a 1-h intravenous infusion of 2.0 or 3.0 g/m2 ifosfamide over 1 or 2 days in combination with 175 mg/m2 paclitaxel and carboplatin at AUC 6 . | [{'class': 'COMB', 'spans': ['ifosfamide', 'paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
Ticlopidine and clopidogrel achieve antiplatelet effects by inhibiting the binding of adenosine 5'-disphosphate to its platelet receptor . | [{'class': 'POS', 'spans': ['Ticlopidine', 'clopidogrel'], 'is_context_needed': True}] |
Irinotecan plus gemcitabine induces both radiographic and CA 19 - 9 tumor marker responses in patients with previously untreated advanced pancreatic cancer . | [{'class': 'POS', 'spans': ['Irinotecan', 'gemcitabine'], 'is_context_needed': True}] |
The patient was treated with a combination of cyclophosphamide , doxorubicin , vincristine , and prednisone as initial management immediately after diagnosis . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'vincristine', 'prednisone'], 'is_context_needed': True}] |
To our knowledge , we present the first reported case of SS associated with linezolid and methadone with a brief review of the literature . | [{'class': 'NEG', 'spans': ['linezolid', 'methadone'], 'is_context_needed': True}] |
Recent clinical trials have reported improved survival for two novel agents ; ipilimumab , a humanized , IgG1 monoclonal antibody that blocks cytotoxic T-lymphocyte-associated antigen 4 ( CTLA-4 ) and vemurafenib , a BRAF ( v-raf murine sarcoma viral oncogene homolog B1 ) inhibitor targeting an activating mutation in the serine-threonine-protein kinase BRAF gene . | [{'class': 'POS', 'spans': ['ipilimumab', 'vemurafenib'], 'is_context_needed': False}] |
Anesthetized rats received a single intravenous injection of epinephrine ( 25 , 50 , or 100 mcg/kg ) ; matched cohorts were pretreated with phentolamine ( 100 mcg/kg ) ; n = 5 for each of the six treatment groups . | [] |
Three interventions exhibited significantly improved OS results over chemotherapy ( all HR < 1 ): Ipilimumab , Nivolumab and Ipilimumab + Chemotherapy . | [{'class': 'POS', 'spans': ['Ipilimumab', 'Nivolumab', 'Ipilimumab', 'Chemotherapy'], 'is_context_needed': False}] |
The breast trial participants studied were those elderly enrolled between 1995 and 1997 and treated with doxorubicin and cyclophosphamide or this combination with paclitaxel . | [{'class': 'COMB', 'spans': ['doxorubicin', 'cyclophosphamide'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1, 2], 'is_context_needed': True}] |
The intensive polychemotherapy regimen eBEACOPP ( bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , and prednisone in escalated doses ) is very active in patients with advanced-stage Hodgkin 's lymphoma , albeit at the expense of severe toxicities . | [{'class': 'COMB', 'spans': ['bleomycin', 'etoposide', 'doxorubicin', 'cyclophosphamide', 'vincristine', 'procarbazine', 'prednisone'], 'is_context_needed': True}] |
Systemic treatments , and here in particular a combined therapeutic regimen of chemotherapy and electron beam , bexarotene , or denileukin diftitox , showed more adverse effects than topical or skin-directed treatments . | [{'class': 'NEG', 'spans': ['bexarotene', 'denileukin diftitox'], 'is_context_needed': False}] |
The incident number of the infected mice was significantly different among groups with different drugs and doses : 2/60 , 16/60 , 10/60 and 10/60 in the groups of Changqing capsule , spiramycin , pyrimethamine and azithromycin respectively ( P < 0.05 ) . | [] |
In total , seven different interventions ( Chloroquine , Mefloquine , Mefloquine artesunate , Proguanil , Pyrimethamine , Sulfadoxine-pyrimethamine , Sulfadoxine-pyrimethamine amodiaquine ) were evaluated in 912 children with SCD . | [] |
We have modeled drug resistance by generating three MM cell lines with acquired resistance to either bortezomib , carfilzomib , or ixazomib . | [] |
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