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This study evaluated the safety and efficacy of inotuzumab ozogamicin ( INO ) , a targeted humanized anti-CD22 antibody conjugated to calicheamicin , plus rituximab ( R-INO ) every 3 weeks , up to six cycles , followed by high dose therapy and autologous stem cell transplant ( HDT-aSCT ) in patients with high-risk relapsed/refractory diffuse large B-cell lymphoma ( DLBCL ) . | [{'class': 'COMB', 'spans': ['inotuzumab', 'rituximab', 'HDT-aSCT'], 'is_context_needed': True}] |
These are the first 2 reports of successful treatment of this condition by use of a combination of methylprednisolone and mycophenolate mofetil , and , in 1 of the cases , additional medication with intravenous immunoglobulin . | [{'class': 'POS', 'spans': ['methylprednisolone', 'mycophenolate'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 1, 2], 'is_context_needed': False}] |
In conclusion , concurrent introduction of ATGAM and tacrolimus is a promising therapeutic combination for GVHD refractory to steroids and cyclosporine . | [{'class': 'POS', 'spans': ['ATGAM', 'tacrolimus'], 'is_context_needed': False}] |
Comparison of geometric least-squares mean PK parameters between arms showed no impact of pertuzumab on the PK of trastuzumab or docetaxel . | [{'class': 'COMB', 'spans': ['pertuzumab', 'trastuzumab'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}] |
We proved experimentally the use of ECEEM for multiplex determination of kinetic parameters describing weak ( 3 mM > K(d ) > 80 μM ) and fast ( 0.25 s ≥ τ ≥ 0.9 ms ) noncovalent interactions between four small molecule drugs ( ibuprofen , S-flurbiprofen , salicylic acid and phenylbutazone ) and α- and β-cyclodextrins . | [{'class': 'COMB', 'spans': ['ibuprofen', 'β-cyclodextrins'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 4], 'is_context_needed': True}, {'class': 'COMB', 'spans': [3, 4], 'is_context_needed': True}] |
We evaluated the stem cell mobilization regimen of high-dose ifosfamide plus etoposide in 32 patients with epithelial ovarian cancer , who had a positive second-look laparatomy or recurrent disease . | [{'class': 'COMB', 'spans': ['ifosfamide', 'etoposide'], 'is_context_needed': True}] |
Combinations of alkylating agents and fludarabine or cladribine are also synergistic in producing significantly enhanced activity against refractory lymphoid malignancies , but at the cost of increased haematological toxicity . | [{'class': 'COMB', 'spans': ['alkylating agents', 'fludarabine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}] |
The pharmacodynamic effects of single doses of trazodone ( 100 mg ) , amitriptyline ( 50 mg ) or placebo either alone or with ethanol ( 0.5 ml/kg ) were investigated in 6 healthy volunteers in a double-blind crossover study . | [{'class': 'COMB', 'spans': ['trazodone', 'ethanol'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 2], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}] |
A 70-year-old Asian man was diagnosed with PVT two months after initiating 5-fluorouracil/leucovorin , irinotecan , and bevacizumab therapy for rectal cancer with liver metastases . | [{'class': 'COMB', 'spans': ['5-fluorouracil/leucovorin', 'irinotecan', 'bevacizumab'], 'is_context_needed': True}] |
Results of cell viability assays revealed that treatment with a combination of imatinib and chemotherapy agents irinotecan or 5‑Fu synergistically inhibited cell growth , compared with treatment with any of these drugs alone . | [{'class': 'POS', 'spans': ['imatinib', 'irinotecan'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
The combination of a fluoropyrimidine ( 5-fluorouracil or capecitabine ) with either oxaliplatin or irinotecan has been widely accepted as standard cytotoxic chemotherapy for either the first- or second-line treatment of mCRC . | [{'class': 'COMB', 'spans': ['fluoropyrimidine', 'oxaliplatin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}] |
Utilizing this data , we suggest that nivolumab plus ipilimumab and cabozantinib may be favored for first-line treatment of specific populations of older patients . | [{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab', 'cabozantinib'], 'is_context_needed': False}] |
The aim of this study was to evaluate all E. coli positive blood cultures collected during a 4-y period in a haematological department using piperacillin plus netilmicin for empiric treatment of febrile episodes . | [{'class': 'COMB', 'spans': ['piperacillin', 'netilmicin'], 'is_context_needed': True}] |
Thirty-five percent ( 6 of 17 ) of the patients receiving docetaxel alone and 53 % ( 19 of 36 ) of those receiving docetaxel and thalidomide have had a PSA decrease of at least 50 % . | [{'class': 'POS', 'spans': ['docetaxel', 'thalidomide'], 'is_context_needed': True}] |
Reduction of ASS1 expression by siRNA significantly sensitized mesothelioma spheroids to the pro-apoptotic effects of bortezomib and of cisplatin plus pemetrexed . | [{'class': 'POS', 'spans': ['pemetrexed', 'cisplatin'], 'is_context_needed': False}] |
In conclusion , the combination of thalidomide and cyclosporine in subtherapeutic doses may be useful for the treatment of skin allografts . | [{'class': 'POS', 'spans': ['thalidomide', 'cyclosporine'], 'is_context_needed': False}] |
Rats were subchronically primed with nicotine , clozapine or saline . | [{'class': 'COMB', 'spans': ['nicotine', 'clozapine', 'saline'], 'is_context_needed': True}] |
New agents , such as taxane , irinotecan and oxaliplatin , combined with old agents , such as cisplatin and 5-FU , are currently under evaluation to further improve treatment outcomes . | [{'class': 'COMB', 'spans': ['taxane', 'cisplatin', '5-FU'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 3, 4], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 3, 4], 'is_context_needed': True}] |
One group was given enalapril ( EN ) 50 mg/l dissolved in the drinking water ; the second received lovastatin ( L ) 15 mg/kg given daily by gavage ; the third received both agents ; the fourth was left untreated , and the final group received no puromycin and served as the control group . | [{'class': 'COMB', 'spans': ['enalapril', 'lovastatin'], 'is_context_needed': True}] |
Using the Killing-curve method , we tested the in vitro bactericidal activity of fosfomycin alone or in combination with vancomycin or teicoplanin at a concentration of 8 microg/mL , that is easily achievable in serum at standard dosing regimens , against seven methicillin-resistant Staphylococcus aureus strains , isolated from patients with well documented device-associated infections unresponsive to or relapsing after glycopeptide therapy . | [{'class': 'COMB', 'spans': ['fosfomycin', 'vancomycin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}] |
Combination therapy with mitomycin , tamoxifen , and UFT proved to be an effective postoperative chemoendocrine therapy for stage II , ER-positive breast cancer . | [{'class': 'POS', 'spans': ['mitomycin', 'tamoxifen', 'UFT'], 'is_context_needed': False}] |
The remaining 76 patients did not receive anti-thymocyte globulin but were given cyclosporine A and methotrexate or mycophenolate mofetil ( group 3 ) . | [{'class': 'COMB', 'spans': ['cyclosporine', 'methotrexate'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}] |
Propranolol significantly decreased the maximum plasma concentration ( Cmax ) and area under the plasma concentration-time curve ( AUC ) of lacidipine ( by 38 % and 42 % , respectively ) whereas lacidipine significantly increased the Cmax and AUC of propranolol ( by 35 % and 26 % , respectively ) ; neither the time to maximum plasma concentration ( tmax ) nor the terminal half-life ( t 1/2 ) were affected . | [{'class': 'COMB', 'spans': ['Propranolol', 'lacidipine'], 'is_context_needed': True}] |
The patient received chemotherapy comprising vincristine , actinomycin D , doxorubicin , cisplatin , and cyclophosphamide . | [{'class': 'COMB', 'spans': ['vincristine', 'doxorubicin', 'cyclophosphamide', 'actinomycin', 'cisplatin'], 'is_context_needed': True}] |
Because gemcitabine has been considered a standard treatment for advanced pancreatic cancer for the past decade , several randomized trials have tested the combination of gemcitabine plus a second agent , including platinum based agents , topoisomerase inhibitors , taxanes , bevacizumab and cetuximab , as biologically " targeted " agents . | [{'class': 'COMB', 'spans': ['gemcitabine', 'bevacizumab'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 3], 'is_context_needed': True}] |
No synergism was found against Pneumococci and Meningococci but also no antagonism of the lower MIC and MBC values seen with ampicillin and penicillin G. The combination of chloramphenicol with either penicillin or ampicillin constitutes a clinically successful therapeutic regimen which is now also proven by in vitro investigations . | [{'class': 'COMB', 'spans': ['ampicillin', 'penicillin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 4], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}] |
Bendamustine is effective both with rituximab and as a monotherapy in rituximab-refractory patients . | [{'class': 'POS', 'spans': ['Bendamustine', 'rituximab'], 'is_context_needed': False}] |
The effects of multiple combination chemotherapy with vincristine , cyclophosphamide ( Endoxan ) , methotrexate , 5-fluorouracil , adriamycin and prednisolone ( VEMFAH ) for advanced breast cancer . | [{'class': 'POS', 'spans': ['vincristine', 'cyclophosphamide', 'methotrexate', '5-fluorouracil', 'adriamycin', 'prednisolone'], 'is_context_needed': True}] |
Association of rash with outcomes in a randomized phase II trial evaluating cetuximab in combination with mitoxantrone plus prednisone after docetaxel for metastatic castration-resistant prostate cancer . | [{'class': 'NEG', 'spans': ['cetuximab', 'mitoxantrone', 'prednisone'], 'is_context_needed': True}] |
CDM mice show decreased Homer1a and Homer1b/c mRNA expression in cortex and blood samples , while chronic treatment with imipramine and fluoxetine or acute ketamine application increases their level only in the cortex . | [{'class': 'COMB', 'spans': ['imipramine', 'fluoxetine'], 'is_context_needed': True}] |
A retrospective analysis was conducted on the clinical data of 122 advanced NSCLC patients with pleural effusion , and among them , 61 received thoracic hyperthermic perfusion with recombinant human endostatin ( ES ) plus nedaplatin ( Endostatin group ) , while the other 61 underwent thoracic hyperthermic perfusion with cisplatin alone ( Cisplatin group ) . | [{'class': 'POS', 'spans': ['endostatin', 'nedaplatin'], 'is_context_needed': True}] |
In addition , stimulation of erythropoiesis with recombinant human erythropoietin , supplemental iron therapy , and improving haemostasis by aprotinin may further reduce homologous blood requirements . | [{'class': 'POS', 'spans': ['erythropoietin', 'iron', 'aprotinin'], 'is_context_needed': True}] |
In the presence of heparin and cortisone and of cortisone alone there was a 4.5- and 2.3-fold reduction , respectively , in the growth of the 9L glioma . | [{'class': 'POS', 'spans': ['heparin', 'cortisone'], 'is_context_needed': False}] |
It was the aim of this study to evaluate maintenance therapy with bevacizumab + capecitabine following induction with bevacizumab + capecitabine + oxaliplatin ( XELOX ) versus bevacizumab + XELOX until progression as first-line therapy in metastatic colorectal cancer ( mCRC ) . | [{'class': 'POS', 'spans': ['bevacizumab', 'capecitabine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3, 4], 'is_context_needed': True}] |
Etoposide ( 25 mg , twice daily ) and prednisone ( 5 mg , twice daily ) were administered orally . | [{'class': 'POS', 'spans': ['Etoposide', 'prednisone'], 'is_context_needed': True}] |
Rosuvastatin + ezetimibe , simvastatin + ezetimibe , and atorvastatin + ezetimibe were the most cost-effective combination therapies for reducing LDL-C levels . | [{'class': 'POS', 'spans': ['Rosuvastatin', 'ezetimibe'], 'is_context_needed': False}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}, {'class': 'POS', 'spans': [4, 5], 'is_context_needed': False}] |
This 40-week open-label extension of the 12-week double-blind Triple Therapy With Olmesartan Medoxomil , Amlodipine , and Hydrochlorothiazide in Hypertensive Patients Study ( TRINITY ) evaluated the efficacy and safety of triple-combination treatments with olmesartan medoxomil , amlodipine besylate , and hydrochlorothiazide ( OM/AML/HCTZ ) in 2112 participants with moderate to severe hypertension . | [{'class': 'POS', 'spans': ['Olmesartan', 'Amlodipine', 'Hydrochlorothiazide'], 'is_context_needed': True}] |
Nithiamide and chlortetracycline + sulfamethazine + penicillin were least effective in preventing SD during the infection + medication and postmedication periods . | [{'class': 'NEG', 'spans': ['chlortetracycline', 'sulfamethazine', 'penicillin'], 'is_context_needed': False}] |
Initial treatment with either neoadjuvant chemoradiation ( CRT ) or induction FOLFOX ( 5-Fluorouracil , leucovorin , and oxaliplatin ) chemotherapy followed by CRT is considered standard treatment for locally advanced rectal cancer . | [{'class': 'POS', 'spans': ['5-Fluorouracil', 'leucovorin', 'oxaliplatin'], 'is_context_needed': False}] |
Prior to the procedure , the child was administered a dental cocktail containing chloral hydrate , hydroxyzine , and methadone . | [{'class': 'NEG', 'spans': ['chloral hydrate', 'hydroxyzine', 'methadone'], 'is_context_needed': True}] |
Additive beneficial effects of fenofibrate combined with atorvastatin in the treatment of combined hyperlipidemia . | [{'class': 'POS', 'spans': ['fenofibrate', 'atorvastatin'], 'is_context_needed': False}] |
Bevacizumab with or without erlotinib as maintenance therapy in patients with metastatic colorectal cancer ( GERCOR DREAM ; OPTIMOX3 ): a randomised , open-label , phase 3 trial . | [{'class': 'POS', 'spans': ['Bevacizumab', 'erlotinib'], 'is_context_needed': True}] |
Eighteen patients with primary or recurrent ovarian cancer were treated with paclitaxel 150 or 110 mg/m2 , respectively , together with gemcitabine 800 mg/m2 and cisplatin 75 mg/m2 , 3 weekly for 6 cycles . | [{'class': 'COMB', 'spans': ['paclitaxel', 'gemcitabine'], 'is_context_needed': True}] |
The cost-minimisation analysis showed that treatment costs for a 12-week course of capecitabine ( Pounds 2132 ) and tegafur with uracil ( Pounds 3385 ) were lower than costs for the intravenous Mayo regimen ( Pounds 3593 ) and infusional regimens on the de Gramont ( Pounds 6255 ) and Modified de Gramont ( Pounds 3485 ) schedules over the same treatment period . | [{'class': 'COMB', 'spans': ['capecitabine', 'tegafur', 'uracil'], 'is_context_needed': True}] |
However , the combination of clindamycin and ciprofloxacin increased mortality associated with B. anthracis Sterne infection , particularly in gamma-irradiated animals . | [{'class': 'NEG', 'spans': ['clindamycin', 'ciprofloxacin'], 'is_context_needed': False}] |
We investigated the maximum tolerated dose , dose-limiting toxicities , and response rate when the selective cyclooxygenase-2 inhibitor celecoxib is added to concurrent irinotecan , cisplatin , and radiation therapy for patients with inoperable stage II-III non-small cell lung cancer ( NSCLC ) . | [{'class': 'POS', 'spans': ['celecoxib', 'irinotecan', 'cisplatin'], 'is_context_needed': True}] |
The combination of docetaxel and estramustine phosphate ( estramustine ) has been reported to be effective for HRPC . | [{'class': 'POS', 'spans': ['docetaxel', 'estramustine'], 'is_context_needed': False}] |
A fixed-dose combination of artesunate + amodiaquine ( ASAQ ) was recently developed . | [{'class': 'POS', 'spans': ['artesunate', 'amodiaquine'], 'is_context_needed': True}] |
All patients have received a median of four and half cycles ( range , 1 - 10 ) of 3-week ( 60 - 75 mg/m2 ) docetaxel regimens and 5 mg prednisone twice per day . | [{'class': 'POS', 'spans': ['docetaxel', 'prednisone'], 'is_context_needed': True}] |
The results of this work encourage the in vivo examination of the therapeutic potential of the combination of bortezomib and rapamycin in Mantle Cell Lymphoma patients . | [{'class': 'POS', 'spans': ['bortezomib', 'rapamycin'], 'is_context_needed': True}] |
Additive effects of combined valsartan and spironolactone on cardiac aldosterone escape in spontaneously hypertensive rats . | [{'class': 'POS', 'spans': ['valsartan', 'spironolactone'], 'is_context_needed': False}] |
54 patients without distant metastases ( T2-T3b , N0-X , M0 ) received 3 cycles of neoadjuvant chemotherapy according to the MVAC protocol ( methotrexate , vinblastine , doxorubicin and cisplatin ) after transurethral resection ( TUR ) followed by cystectomy . | [{'class': 'POS', 'spans': ['methotrexate', 'vinblastine', 'doxorubicin', 'cisplatin'], 'is_context_needed': True}] |
The objective of this study was to compare cycle control , efficacy and tolerance of an oral contraceptive containing 20 microg ethinylestradiol and 150 microg desogestrel with a preparation containing 30 microg ethinylestradiol combined with 75 microg gestodene . | [{'class': 'POS', 'spans': ['ethinylestradiol', 'desogestrel'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
They were assigned to either receiving a COCP containing 20 mcg ethinyl estradiol/150 mg desogestrel for two continuous cycle or NSAID ; mefenamic acid 500 mg TDS for 5 days , 21 days apart for two cycles . | [{'class': 'POS', 'spans': ['ethinyl', 'desogestrel'], 'is_context_needed': True}] |
Preclinical data suggest that enzastaurin and bevacizumab may have complementary effects in inhibiting angiogenesis . | [{'class': 'POS', 'spans': ['enzastaurin', 'bevacizumab'], 'is_context_needed': False}] |
Trials have demonstrated decreased relapse with perioperative methotrexate , vinblastine , doxorubicin and cisplatin ( M-VAC ) chemotherapy in patients with muscle invasive bladder cancer . | [{'class': 'POS', 'spans': ['methotrexate', 'vinblastine', 'doxorubicin', 'cisplatin'], 'is_context_needed': False}] |
m2 on day 1 , oxaliplatin 85 mg/m² day 1 and capecitabine twice-daily dose of 625 mg/ m2 , p.o . for 2 weeks ) every 3 | [{'class': 'POS', 'spans': ['oxaliplatin', 'capecitabine'], 'is_context_needed': True}] |
However , two phase III trials demonstrated that incorporation of oxaliplatin to capecitabine with RT did not improve early outcomes and , by contrast , increased toxicity . | [{'class': 'NEG', 'spans': ['oxaliplatin', 'capecitabine'], 'is_context_needed': False}] |
The addition of everolimus to bicalutamide treatment of resistant tumours significantly reduced tumour growth rates and tumour volumes . | [{'class': 'POS', 'spans': ['everolimus', 'bicalutamide'], 'is_context_needed': False}] |
To assess plasma steady-state pharmacokinetics ( PK ) of rifampicin , isoniazid , saquinavir and ritonavir in HIV and tuberculosis ( TB ) co-infected patients , and investigate potential interactions between TB drugs and protease inhibitors ( PIs ) . | [{'class': 'COMB', 'spans': ['isoniazid', 'saquinavir', 'ritonavir', 'rifampicin'], 'is_context_needed': True}] |
We randomly assigned 808 patients with HER2-positive metastatic breast cancer to receive placebo plus trastuzumab plus docetaxel ( control group ) or pertuzumab plus trastuzumab plus docetaxel ( pertuzumab group ) as first-line treatment until the time of disease progression or the development of toxic effects that could not be effectively managed . | [{'class': 'POS', 'spans': ['pertuzumab', 'trastuzumab', 'docetaxel'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}] |
Toxicological studies revealed that the oral LD50 for thiabendazole in mice was 2200 mg/kg , and when combined with 140 mg/kg of aspirin , the LD50 was reduced to 900 mg/kg . | [{'class': 'NEG', 'spans': ['thiabendazole', 'aspirin'], 'is_context_needed': False}] |
Azacitidine and enasidenib are two therapies available for treatment of acute myelogenous leukemia ( AML ) , and the mechanisms of action of these drugs involve alteration of aberrant DNA methylation . | [{'class': 'COMB', 'spans': ['Azacitidine', 'enasidenib'], 'is_context_needed': True}] |
Good , moderate and mild pain relief were noted in 19 ( 41 % ) , six ( 13 % ) and seven ( 15 % ) patients on lamotrigine and 13 ( 28 % ) , five ( 11 % ) and 15 ( 33 % ) patients on amitriptyline , respectively , by patient 's global assessment of efficacy and safety . | [{'class': 'NEG', 'spans': ['lamotrigine', 'amitriptyline'], 'is_context_needed': True}] |
The majority of the evidence comes from studies of bevacizumab and triamcinolone used as primary therapy for DMO . | [{'class': 'COMB', 'spans': ['bevacizumab', 'triamcinolone'], 'is_context_needed': True}] |
Doxorubicin and ifosfamide are currently the two main drugs for the treatment of soft tissue sarcomas in adults . | [{'class': 'POS', 'spans': ['Doxorubicin', 'ifosfamide'], 'is_context_needed': True}] |
The skin and oral mucous membrane lesions recurred after effective treatments with methylprednisolone pulse therapy and combination therapy with prednisolone and cyclosporine . | [{'class': 'COMB', 'spans': ['prednisolone', 'cyclosporine'], 'is_context_needed': True}] |
Incorporation of colistin significantly accelerated the release of ciprofloxacin from the DMPG anionic liposomes . | [{'class': 'POS', 'spans': ['colistin', 'ciprofloxacin'], 'is_context_needed': False}] |
Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin 's lymphomas . | [{'class': 'POS', 'spans': ['decitabine', 'vorinostat'], 'is_context_needed': True}] |
Epirubicin ( 35 mg/m(2 ) ) and cyclophosphamide ( 400 mg/m(2 ) ) were administered from day 2 to day 4 , every 4 weeks . | [{'class': 'POS', 'spans': ['Epirubicin', 'cyclophosphamide'], 'is_context_needed': True}] |
Our patient could be weaned from LVAD probably due to the combination management strategy employing mitral valvuloplasty , use of cardiac resynchronization therapy , and taking carvedilol with spironolactone . | [{'class': 'POS', 'spans': ['carvedilol', 'spironolactone'], 'is_context_needed': False}] |
Serum hydroxyzine and cetirizine concentrations were above the limit of quantitation ( 0.1 ng/ml ) of the assay | [{'class': 'NEG', 'spans': ['hydroxyzine', 'cetirizine'], 'is_context_needed': True}] |
Although well tolerated , the efficacy of everolimus and vinorelbine combination therapy was not superior to vinorelbine monotherapy . | [{'class': 'NEG', 'spans': ['everolimus', 'vinorelbine'], 'is_context_needed': False}] |
In addition , biochemical examinations revealed that docetaxel could induce phosphorylation of both bcl-2 and c-raf-1 , but these changes were inhibited when tumor cells were pretreated or simultaneously treated with doxorubicin . | [{'class': 'NEG', 'spans': ['docetaxel', 'doxorubicin'], 'is_context_needed': False}] |
Enhancement of radiation-induced downstaging of rectal cancer by fluorouracil and high-dose leucovorin chemotherapy . | [{'class': 'POS', 'spans': ['fluorouracil', 'leucovorin'], 'is_context_needed': False}] |
Final analysis of a phase II study of nivolumab in combination with ipilimumab for unresectable chemotherapy-naive advanced melanoma . | [{'class': 'NEG', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': True}] |
In some relatively developed regions in China , infliximab and rituximab may be a favorable cost-effective alternative for moderate to severe RA . | [{'class': 'POS', 'spans': ['infliximab', 'rituximab'], 'is_context_needed': False}] |
Topiramate CR treatment produced significant weight loss and meaningful improvements in A1C and blood pressure in obese patients with type 2 diabetes treated with diet and exercise or in combination with metformin . | [{'class': 'POS', 'spans': ['Topiramate', 'metformin'], 'is_context_needed': False}] |
To compare efficacy and toxicity of bolus application of chemotherapy protocol , oxaliplatin , fluorouracil ( bolus ) , leucovorin ( folfox ) between two groups of patients in the therapy of metastatic colorectal carcinoma ( mCRC ) . | [{'class': 'COMB', 'spans': ['oxaliplatin', 'fluorouracil', 'leucovorin'], 'is_context_needed': True}] |
Verapamil and quinine were added in patients with tumors failing to respond or progressing on CVAD alone . | [{'class': 'POS', 'spans': ['Verapamil', 'quinine'], 'is_context_needed': True}] |
However , dipyridamole had no effect on both the influx and efflux of epirubicin in doxorubicin-sensitive cells . | [{'class': 'NEG', 'spans': ['dipyridamole', 'epirubicin'], 'is_context_needed': True}] |
This study aims to evaluate the potential role of combination therapy with docetaxel , flavopiridol , or 5-FU in modulating chemosensitivity and better understand how they might be used clinically . | [{'class': 'POS', 'spans': ['docetaxel', 'flavopiridol'], 'is_context_needed': True}] |
Dipyridamole or dipyridamole and acetylsalicyclic acid were used in 22 pregnancies . | [{'class': 'COMB', 'spans': ['dipyridamole', 'acetylsalicyclic acid'], 'is_context_needed': True}] |
Bevacizumab and trastuzumab are efficacious for treatment of advanced or HER2-positive metastatic breast cancer ; however , few data exist for this regimen in inflammatory breast cancer . | [{'class': 'COMB', 'spans': ['Bevacizumab', 'trastuzumab'], 'is_context_needed': True}] |
Rats were distributed into three groups ( n = 5 ) according to the drug studied namely , 50 % enantiomeric excess bupivacaine mixture ( 5 μg/mL ) ; pancuronium ( 2 μg/mL ) ; 50 % enantiomeric excess bupivacaine mixture + pancuronium . | [{'class': 'COMB', 'spans': ['bupivacaine', 'pancuronium'], 'is_context_needed': True}] |
Blood was sampled immediately prior to premedication ( temazepam ) , after induction of anaesthesia ( fentanyl and thiopentone ) and at 10-minute intervals until the end of the procedure ( N2O maintenance , vecuronium relaxation ) . | [{'class': 'COMB', 'spans': ['temazepam', 'fentanyl', 'thiopentone', 'vecuronium'], 'is_context_needed': True}] |
The planned concomitant treatment in group B was : bleomycin 5 units twice a week i.m . , total dose 70 units , mitomycin C 15 mg/m2 i.v . after delivery of 10 Gy , and 10 mg/m2 i.v . on the last day of radiotherapy . | [{'class': 'POS', 'spans': ['bleomycin', 'mitomycin'], 'is_context_needed': True}] |
The study objectives were to evaluate the safety , tolerability , and preliminary efficacy of multiple doses of dulanermin in combination with modified FOLFOX6 and bevacizumab in previously untreated patients with locally advanced , recurrent , or metastatic colorectal cancer . | [{'class': 'POS', 'spans': ['dulanermin', 'FOLFOX6', 'bevacizumab'], 'is_context_needed': True}] |
The study was conducted in 90 patients operated on for unilateral breast cancer who were then assigned to receive either 12 intravenous cycles of cyclophosphamide , methotrexate and fluorouracil ( CMF ) every three weeks , or no further treatment . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'methotrexate', 'fluorouracil'], 'is_context_needed': True}] |
This study compared the efficacy of topical emedastine 0.05 % ophthalmic solution with that of oral loratadine 10 mg and their combination in the conjunctival allergen challenge model of allergic conjunctivitis . | [{'class': 'POS', 'spans': ['emedastine', 'loratadine'], 'is_context_needed': True}] |
Mycophenolate mofetil resulted in rapid improvement of steroid-refractory immune-related adverse event hepatitis , induced by nivolumab plus ipilimumab . | [{'class': 'COMB', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': True}] |
Resistant isolates emerged quickly and uniformly in all patients administered nevirapine either as monotherapy or in combination with zidovudine ( AZT ) . | [{'class': 'COMB', 'spans': ['nevirapine', 'zidovudine'], 'is_context_needed': True}] |
Postoperative combination chemotherapy for six cycles with cisplatin ( 100 mg/m2 per day for 1 day every 3 weeks ) , bleomycin ( 15 units intravenously weekly for 18 weeks ) and etoposide ( 100 mg/m2 per day for 3 days every 3 weeks ) were given and the tumor responded dramatically . | [{'class': 'POS', 'spans': ['cisplatin', 'bleomycin', 'etoposide'], 'is_context_needed': False}] |
The other received chemotherapy including prednisone , vincristine , cytarabine and L-asparaginase , combined with intrathecal injections of methotrexate , dexamethasone and Ara-C and supporting treatment . | [{'class': 'POS', 'spans': ['prednisone', 'vincristine', 'cytarabine', 'L-asparaginase'], 'is_context_needed': True}] |
Then , neoadjuvant chemotherapy ( NAC ) consisting of a combination of 5-fluorouracil ( 5-FU ) , oxaliplatin , irinotecan , and leucovorin ( FOLFOXIRI ) was planned , followed by primary tumor resection . | [{'class': 'POS', 'spans': ['5-fluorouracil', 'oxaliplatin', 'irinotecan', 'leucovorin'], 'is_context_needed': True}] |
Interestingly , aspirin not only significantly inhibited the growth of TNBC cells , but also attenuated YAP and β-catenin expression by upregulating the E3 ubiquitin ligase β-TrCP to abolished docetaxel and vinorelbine resistance . | [{'class': 'POS', 'spans': ['aspirin', 'docetaxel', 'vinorelbine'], 'is_context_needed': False}] |
No alterations in paclitaxel or doxorubicin pharmacokinetics were observed when the drugs were administered alone versus in combination . | [{'class': 'COMB', 'spans': ['paclitaxel', 'doxorubicin'], 'is_context_needed': True}] |
Twenty-seven received rituximab mainly in addition to high-dose cytarabine and etoposide ( n = 18 ) and/or ifosfamide , carboplatin , and etoposide ( n = 7 ) . | [{'class': 'COMB', 'spans': ['rituximab', 'cytarabine', 'etoposide', 'ifosfamide', 'carboplatin', 'etoposide'], 'is_context_needed': True}] |
Both mono and combination therapies achieved the primary efficacy parameters : lowered diastolic blood pressure ( at trough ) more than placebo , p < 01 ( except the 120 mg verapamil SR , NS , 0.5 mg trandolapril , 0.5/180 and 2/120 combinations , p < 05 ) , yielded a trough to peak ratio of > 0.52 and had higher percentages of responders compared to placebo . | [{'class': 'POS', 'spans': ['verapamil', 'trandolapril'], 'is_context_needed': False}] |
In metastastic patients , the combination of gemcitabine and cisplatin has become the new standard regimen due to a lower toxicity in comparison to the combination of methotrexate , vinblastine , doxorubicin , and cisplatin ( MVAC ) . | [{'class': 'POS', 'spans': ['gemcitabine', 'cisplatin'], 'is_context_needed': False}, {'class': 'COMB', 'spans': [1, 2, 3], 'is_context_needed': True}] |
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