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However , we observed significant decreases in the left ventricular mass index and urinary albumin to creatinine ratio in the valsartan group but not in the amlodipine group . | [] |
Effects of chloroquine , mefloquine and quinine on natural killer cell activity in vitro . | [] |
Fulvestrant ( intramuscular injection 250 mg month(-1 ) ) was found to be at least as effective as anastrozole ( orally 1 mg day(-1 ) ) for time to progression ( 5.5 vs 4.1 months , respectively ( hazard ratio ( HR ): 0.95 ; 95.14 % confidence interval ( CI ) , 0.82 - 1.10 ; P=0.48 ) ) and objective response 19.2 vs 16.5 % , respectively ; treatment difference 2.75 % ; 95.14 % CI , -2.27 to 9.05 % ; P=0.31 ) . | [] |
Risk factors associated with cardiotoxicity within 2 years of doxorubicin administration included age [ adjusted hazard ratio ( aHR ) = 1.02 , 95 % confidence interval ( CI ) 1.00 - 1.04 ; p = 0.05 ] , metastasis ( aHR = 2.66 ; 95 % CI 1.36 - 5.20 ; p < 0.01 ) , and concomitant trastuzumab ( aHR = 4.08 ; 95 % CI 2.31 - 7.21 ; p | [{'class': 'NEG', 'spans': ['doxorubicin', 'trastuzumab'], 'is_context_needed': True}] |
Twenty-four patients have been treated to date , and the maximum tolerated dose has been reached at paclitaxel 185 mg/m2 and carboplatin 350 mg/m2 . | [{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
FAB M5 was significantly more sensitive than FAB M4 to most drugs frequently used in AML , as indicated by the following ratios of median sensitivities : the anthracyclines ( 2.6- to 3.2-fold ) , mitoxantrone ( 12.5-fold ) , etoposide ( 8.7-fold ) , and cytarabine ( 2.9-fold ) . | [] |
[ Aztreonam or gentamicin combined with piperacillin as empiric antibiotic therapy during neutropenia of patients with hematologic diseases ] . | [{'class': 'POS', 'spans': ['Aztreonam', 'piperacillin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': True}] |
The present study was undertaken to further elucidate the effect of salbutamol on the pharmacokinetics of digoxin in man . | [{'class': 'COMB', 'spans': ['salbutamol', 'digoxin'], 'is_context_needed': True}] |
Mecamylamine reversed the effects of nicotine on SHR performance . | [{'class': 'POS', 'spans': ['Mecamylamine', 'nicotine'], 'is_context_needed': True}] |
The combination of sub-effective doses of leflunomide and cyclosporin A resulted in significant inhibition of chronic arthritis . | [{'class': 'POS', 'spans': ['leflunomide', 'cyclosporin'], 'is_context_needed': False}] |
In the metastatic setting , FOLFIRINOX ( folinic acid , 5-fluorouracil , irinotecan , and oxaliplatin ) , and nab-paclitaxel plus gemcitabine have yielded only modest improvements in survival . | [{'class': 'COMB', 'spans': ['folinic', '5-fluorouracil', 'irinotecan', 'oxaliplatin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [4, 5], 'is_context_needed': True}] |
Patients in arm 1 ( n = 88 ) received 4 cycles of paclitaxel and carboplatin followed by 2 to 4 cycles of gemcitabine-based combination chemotherapy . | [{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin', 'gemcitabine-based'], 'is_context_needed': True}] |
In patients receiving digoxin and propafenone simultaneously , the SDCs should be monitored and the digoxin dose reduced if there is evidence of toxicity . | [{'class': 'COMB', 'spans': ['digoxin', 'propafenone'], 'is_context_needed': True}] |
To review the clinical effectiveness and cost-effectiveness evidence base for lapatinib ( LAP ) in combination with an aromatase inhibitor ( AI ) and trastuzumab ( TRA ) in combination with an AI for the first-line treatment of patients who have hormone receptor-positive (HR+)/human epidermal growth factor 2-positive ( HER2 + ) mBC . | [{'class': 'POS', 'spans': ['lapatinib', 'AI'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': True}] |
Since combination therapy with nateglinide and vildagliptin restored the decrease in pancreatic beta cell mass , our present findings suggest that combination therapy could be a promising therapeutic strategy for postprandial dysmetabolism associated with obese and insulin resistance . | [{'class': 'POS', 'spans': ['nateglinide', 'vildagliptin'], 'is_context_needed': False}] |
Paclitaxel , doxorubicin , tamoxifen , erlotinib , gefitinib , temozolomide , and methotrexate are among therapeutic agents whose efficacy is influenced by the expression of H19 . | [] |
Patients were randomised to receive either four or eight courses of cytotoxic chemotherapy with cyclophosphamide , vincristine and etoposide and also randomised to receive , on disease progression , either second line chemotherapy ( methotrexate and doxorubicin ) or symptomatic treatment only . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'vincristine', 'etoposide'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [3, 4], 'is_context_needed': True}] |
Amisulpride demonstrated a greater improvement in BPRS total scores ( P<0.05 ) and PANSS negative subscores ( P=0.0001 ) than haloperidol after 12 months of treatment in chronic schizophrenic patients with acute exacerbations . | [] |
In patients with acute cholecystitis , ampicillin plus tobramycin , cefoperazone and piperacillin had clinical cure rates of 85 , 95 and 95 per cent , respectively . | [] |
A retrospective analysis of the Phase III trial of pemetrexed versus docetaxel shows a statistically significant longer toxicity-free survival time for pemetrexed compared with docetaxel . | [] |
Tazobactam has inhibitory activity , and therefore protects piperacillin against Richmond and Sykes types II , III , IV and V beta-lactamases , staphylococcal penicillinase and extended-spectrum beta-lactamases . | [{'class': 'POS', 'spans': ['Tazobactam', 'piperacillin'], 'is_context_needed': True}] |
The diagnosis was stage IIIA HHV-8-LBL , and he was treated with 6 cycles of R-EPOCH ( rituximab , etoposide , vincristine , doxorubicin , cyclophosphamide , and prednisone ) infusion chemotherapy . | [{'class': 'POS', 'spans': ['rituximab', 'etoposide', 'vincristine', 'doxorubicin', 'cyclophosphamide', 'prednisone'], 'is_context_needed': True}] |
Our objective was to define the maximum tolerated dose of an escalating dose of ifosfamide in combination with a fixed dose of doxorubicin supported by granulocyte colony-stimulating factor ( Neupogen ) . | [{'class': 'POS', 'spans': ['ifosfamide', 'doxorubicin'], 'is_context_needed': True}] |
A combined analysis of two pivotal randomized trials of a single dose of pegfilgrastim per chemotherapy cycle and daily Filgrastim in patients with stage II-IV breast cancer . | [{'class': 'POS', 'spans': ['pegfilgrastim', 'Filgrastim'], 'is_context_needed': True}] |
[ Nilotinib in patients with chronic myeloid leukemia without response to imatinib ] . | [] |
At initial treatment with dabrafenib plus trametinib , three patients achieved a partial response and one patient achieved a complete response . | [{'class': 'POS', 'spans': ['dabrafenib', 'trametinib'], 'is_context_needed': True}] |
We performed this meta-analysis to evaluate the clinical efficacy and safety of gemcitabine plus cisplatin ( GP ) and paclitaxel plus cisplatin ( TP ) combined with thermotherapy in the treatment of NSCLC , as well as to provide reference for clinical practice and future research . | [{'class': 'POS', 'spans': ['gemcitabine', 'cisplatin', 'thermotherapy'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3, 4], 'is_context_needed': True}] |
The pharmacodynamic effects of ticagrelor were preserved when ticagrelor was given during infusion of cangrelor . | [{'class': 'POS', 'spans': ['ticagrelor', 'cangrelor'], 'is_context_needed': False}] |
A 49-year-old woman diagnosed with International Federation of Obstetricians and Gynecologists stage 2018 IIIC2 locally advanced undifferentiated cervical cancer received first-line chemoradiotherapy followed by carboplatin , paclitaxel , and bevacizumab with partial response . | [{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel', 'bevacizumab'], 'is_context_needed': True}] |
Sipuleucel-T , cabazitaxel , abiraterone , enzalutamide and radium-223 have been approved in the pre- or post-docetaxel setting in metastatic CRPC during the last few years . | [{'class': 'POS', 'spans': ['Sipuleucel-T', 'cabazitaxel', 'abiraterone', 'enzalutamide', 'radium-223'], 'is_context_needed': True}] |
Therefore , we conducted this phase II study to evaluate the activity and toxicity of the combination paclitaxel and gemcitabine in advanced NSCLC . | [{'class': 'NEG', 'spans': ['paclitaxel', 'gemcitabine'], 'is_context_needed': True}] |
Two of these antibodies , cetuximab ( Erbitux ) und bevacizumab ( Avastin ) , directed against the epidermal growth factor receptor ( EGFR ) and the vascular epithelial growth factor ( VEGF ) , respectively , have recently been approved for use in metastatic colorectal cancer . | [] |
Physically cross-linked beta-lactoglobulin ( BLG ) protein gels containing theophylline and sulfamethoxazole low molecular weight drugs were prepared in 50 % ethanol solution at pH 8 and two protein concentrations ( 6 and 7 % ( w/v ) ) . | [] |
Ciprofloxacin , 500 mg orally twice a day plus antifungal prophylaxis , fluconazole 50 mg once daily plus amphotericin B tablets or suspension and tablets , each 200 mg four times a day , was given . | [{'class': 'POS', 'spans': ['Ciprofloxacin', 'fluconazole', 'amphotericin'], 'is_context_needed': True}] |
In some recently updated clinical guidelines , the fully humanized monoclonal antibody panitumumab , combined with irinotecan , has been recommended as an optional third-line chemotherapy for KRAS wild-type metastatic colorectal cancer ( mCRC ) . | [{'class': 'POS', 'spans': ['panitumumab', 'irinotecan'], 'is_context_needed': False}] |
A monocentric phase I study of vemurafenib plus cobimetinib plus PEG-interferon ( VEMUPLINT ) in advanced melanoma patients harboring the V600BRAF mutation . | [{'class': 'POS', 'spans': ['vemurafenib', 'cobimetinib', 'VEMUPLINT'], 'is_context_needed': True}] |
Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma . | [{'class': 'NEG', 'spans': ['tremelimumab', 'sunitinib'], 'is_context_needed': True}] |
A working group convened by the Centers for Disease Control recommended three antibiotics for the treatment of recurrent and persistent acute otitis media : ( 1 ) amoxicillin/clavulanate in combination with amoxicillin ( high dose amoxicillin regimen , 80 to 90 mg/kg/day ) ; ( 2 ) cefuroxime axetil ( standard dose , 30 mg/kg/day ) ; and ( 3 ) ceftriaxone ( possibly requiring up to three injections to optimize clinical success ) . | [{'class': 'POS', 'spans': ['amoxicillin/clavulanate', 'amoxicillin'], 'is_context_needed': True}] |
On the basis of the estimated costs of infective complications , cefotaxime and ceftriaxone appear equally effective for the prevention of infective complications after abdominal surgery . | [] |
The epidermal growth factor receptor tyrosine kinase inhibitors ( EGFR TKIs ) like erlotinib and gefitinib have been extensively studied . | [] |
Patients who had failed only one prior chemotherapy regimen and had Eastern Cooperative Oncology Group ( ECOG ) Performance Status ( PS ) ≤2 were randomised to either : pemetrexed 500 mg/m(2 ) on day 1 plus erlotinib 150 mg daily on days 2 - 14 ; erlotinib 150 mg daily ; or pemetrexed 500 mg/m(2 ) on day 1 of a 21-day cycle until discontinuation criteria were met . | [{'class': 'POS', 'spans': ['pemetrexed', 'erlotinib'], 'is_context_needed': True}] |
This study was conducted to test the feasibility of reducing the interval between cycles of doxorubicin , cyclophosphamide , etoposide ( ACE ) chemotherapy to 2 weeks , thereby increasing dose intensity , by adding granulocyte colony-stimulating factor ( G-CSF ) to reduce the duration of neutropenia following a cycle . | [{'class': 'POS', 'spans': ['doxorubicin', 'cyclophosphamide', 'etoposide', 'G-CSF'], 'is_context_needed': True}] |
The rate of down-stage to pT1 or less was 59 % for methotrexate , vinblastine , doxorubicin and cisplatin , and 53 % for gemcitabine and carboplatin ( P = 0.624 ) . | [{'class': 'POS', 'spans': ['gemcitabine', 'carboplatin'], 'is_context_needed': True}] |
The combined irrigation of bupivacaine and ketorolac showed a clinically significant reduction of pain in the first postoperative hour and on postoperative day 5 . | [{'class': 'POS', 'spans': ['bupivacaine', 'ketorolac'], 'is_context_needed': False}] |
In group I , clinical response was observed in 10 of 19 febrile episodes ( 52.6 % ) treated with carbenicillin plus gentamicin and in 10 of 14 ( 71.4 % ) treated with latamoxef ( p greater than 0.05 ) . | [{'class': 'COMB', 'spans': ['carbenicillin', 'gentamicin'], 'is_context_needed': True}] |
Following lapatinib and trastuzumab , the HER2-E and ERBB2 (HER2-E/ERBB2)-high group showed a higher pCR rate compared to the rest ( 44.5 % , 95 % confidence interval [ CI ] = 35.4 % to 53.9 % vs 11.6 % , 95 % CI = 6.9 % to 18.0 % ; adjusted odds ratio [ OR ] = 6.05 , 95 % CI = 3.10 to 11.80 , P < .001 ) . | [{'class': 'POS', 'spans': ['lapatinib', 'trastuzumab'], 'is_context_needed': False}] |
A Synergistic Anti-Cancer Effect of Troglitazone and Lovastatin in a Human Anaplastic Thyroid Cancer Cell Line and in a Mouse Xenograft Model . | [{'class': 'POS', 'spans': ['Troglitazone', 'Lovastatin'], 'is_context_needed': False}] |
Fingolimod sensitizes EGFR wild‑type non‑small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest . | [{'class': 'POS', 'spans': ['Fingolimod', 'lapatinib'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone ( GnRH ) agonist triptorelin or the GnRH antagonist cetrorelix . | [] |
In vitro effects of racemates , separate enantiomers and major metabolites of mefloquine and halofantrine on metoprolol biotransformation by rat liver microsomes . | [] |
Other studies are evaluating the use of capecitabine , oxaliplatin , and the anti-epidermal growth factor receptor agent cetuximab with RT in this malignancy . | [] |
Bacteriological , histopathologic , and clinical outcomes after treatment using moxifloxacin , moxifloxacin and dexamethasone combination , and vancomycin were comparable . | [{'class': 'COMB', 'spans': ['moxifloxacin', 'dexamethasone'], 'is_context_needed': True}] |
Combining erythromycin , clarithromycin , or azithromycin with rifampin resulted in a significant ( P≤0.005 ) decrease in MPC and MPC/MIC ratio . | [{'class': 'POS', 'spans': ['erythromycin', 'rifampin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': False}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}] |
This was confirmed and show that the dCK levels are retained upon co-treatment , indicating a clinical use for bortezomib treatment in combination with cytarabine to avoid development of resistance . | [{'class': 'POS', 'spans': ['bortezomib', 'cytarabine'], 'is_context_needed': False}] |
Artemether , artesunate , praziquantel and tribendimidine administered singly at different dosages against Clonorchis sinensis : a comparative in vivo study . | [] |
The agents studied include : propranolol , timolol , metoprolol , practolol , atenolol and the combined alpha and beta adrenoceptor blocking agent , labetalol . | [] |
Effects of fenofibrate and its combination with lovastatin on the expression of genes involved in skeletal muscle atrophy , including FoxO1 and its targets . | [{'class': 'NEG', 'spans': ['fenofibrate', 'lovastatin'], 'is_context_needed': True}] |
Idasanutlin was tolerable alone and in combination with cytarabine . | [{'class': 'POS', 'spans': ['Idasanutlin', 'cytarabine'], 'is_context_needed': False}] |
Cell surface proteins induced by fludarabine and cladribine may be targets for therapeutic antibodies . | [] |
After seven days of chemotherapy with 5-fluorouracil , oxaliplatin and bevacizumab , exploratory surgery revealed a perforation at the ileum . | [{'class': 'NEG', 'spans': ['5-fluorouracil', 'oxaliplatin', 'bevacizumab'], 'is_context_needed': False}] |
Nausea graded none or mild 24 h after the start of cisplatin infusion was reported in 71 and 69 % of patients in the 8- and 32-mg ondansetron groups , respectively , and in 73 % of patients in the granisetron group . | [{'class': 'POS', 'spans': ['cisplatin', 'ondansetron'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
Relatively recent studies have shown that dexmedetomidine is able to decrease circulating plasma norepinephrine and epinephrine concentration in approximately 50 % , decreases brain blood flow by directly acting on post-synaptic alpha 2 receptors , decreases CSF pressure without ischemic suffering and effectively decrease brain metabolism and intracranial pressure and also , able to decrease injury caused by focal ischemia . | [] |
He was initially treated with combination chemotherapy regimen of vincristine , actinomycin-D and cyclophosphamide ( VAC therapy ) . | [{'class': 'COMB', 'spans': ['vincristine', 'cyclophosphamide', 'actinomycin-D'], 'is_context_needed': True}] |
However , when a lung mass was noted two months later , he started to receive combination chemotherapy consisting of cyclophosphamide , adriamycin , vincristine , and prednisolone every three months . | [{'class': 'COMB', 'spans': ['cyclophosphamide', 'vincristine', 'prednisolone', 'adriamycin'], 'is_context_needed': True}] |
We used MCF-7 and MDA-MB231 breast cancer cells incubated with Curcumin and Quercetin for 24h , in the absence and presence of Somatostatin , at their EC50 concentrations , to evaluate membrane fatty acid-based functional lipidomics together with the follow-up of EGFR and MAPK signaling pathways . | [{'class': 'COMB', 'spans': ['Curcumin', 'Somatostatin', 'Quercetin'], 'is_context_needed': True}] |
Following corneal scrapings and culture , topical 0.5 % moxifloxacin and 0.5 % tobramycin were administered hourly . | [{'class': 'COMB', 'spans': ['moxifloxacin', 'tobramycin'], 'is_context_needed': True}] |
Combination treatment with cetuximab and nystatin selectively increased cetuximab uptake by tumor tissues , translating into potentiated antitumor efficacy of cetuximab in vivo ( A431 and A549 tumors ) . | [{'class': 'POS', 'spans': ['cetuximab', 'nystatin'], 'is_context_needed': False}] |
The effects of combination therapy with chenodeoxycholic acid ( CDCA ) and simvastatin on serum cholestanol , low-density lipoprotein ( LDL ) cholesterol , and lathosterol levels were investigated in seven adult patients with cerebrotendinous xanthomatosis ( CTX ) who were on long-term treatment with CDCA . | [{'class': 'POS', 'spans': ['chenodeoxycholic', 'simvastatin'], 'is_context_needed': True}] |
Paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) has been demonstrated to be highly effective in treating patients with advanced breast cancer , including those with anthracycline-resistant breast cancer , a fact that has led to efforts to combine paclitaxel and anthracyclines . | [{'class': 'COMB', 'spans': ['paclitaxel', 'anthracyclines'], 'is_context_needed': True}] |
In patients with NPSLE , the use of high-dose corticosteroids is recommended in combination with immunosuppressants , such as mycophenolate mofetil and intravenous cyclophosphamide pulse therapy . | [{'class': 'POS', 'spans': ['mycophenolate', 'corticosteroids'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}] |
Thirty-three women diagnosed with metastatic breast cancer participated in a phase 1 clinical trial of a new combination of cyclophosphamide ( CTX ) and mitoxantrone ( MXT ) , with dose escalation of paclitaxel . | [{'class': 'COMB', 'spans': ['cyclophosphamide', 'mitoxantrone', 'paclitaxel'], 'is_context_needed': True}] |
Furthermore , in non-metastatic castration-resistant prostate cancer ( M0 CRPC ) , two second-generation anti-androgens , apalutamide and enzalutamide , when used in combination with ADT , have demonstrated a significant benefit in metastasis-free survival . | [{'class': 'POS', 'spans': ['apalutamide', 'ADT'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}] |
Phase Ib Study of the Oral Proteasome Inhibitor Ixazomib ( MLN9708 ) and Fulvestrant in Advanced ER+ Breast Cancer Progressing on Fulvestrant . | [{'class': 'POS', 'spans': ['Ixazomib', 'Fulvestrant'], 'is_context_needed': True}] |
Pharmacokinetic studies showed that chronic lymphocytic leukemia involving more than 80 % of the bone marrow at study start was associated with lower trough concentrations of alemtuzumab and rituximab , and that higher trough serum concentrations of alemtuzumab were associated with complete bone marrow clearance . | [{'class': 'POS', 'spans': ['alemtuzumab', 'rituximab'], 'is_context_needed': True}] |
Compared with risedronate alone , at 6 months , risedronate plus atorvastatin produced significantly greater increases in the bone mineral density of the lumbar spine ( 1.58 % versus 0.75 % , p < 0.05 ) . | [{'class': 'POS', 'spans': ['risedronate', 'atorvastatin'], 'is_context_needed': False}] |
Patients registered with the German ACC Registry with refractory ACC progressing after cytotoxic therapies were offered treatment with bevacizumab ( 5 mg/kg body weight i.v . every 21 days ) and oral capecitabine ( 950 mg/m(2 ) twice daily for 14 days followed by 7 days of rest ) in 2006 - 2008 . | [{'class': 'NEG', 'spans': ['bevacizumab', 'capecitabine'], 'is_context_needed': True}] |
Patients who had pathologically been proven to have measurable lesions were treated with paclitaxel ( 200 mg/m(2 ) for 3 h ) and carboplatin [ area under the concentration-time curve ( AUC = 6 ) ] on day 1 and in 21 day cycles . | [{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
Eligible patients received ramucirumab ( 10mg/kg ) + dacarbazine ( 1000 mg/m(2 ) ) ( Arm A ) or ramucirumab only ( 10mg/kg ) ( Arm B ) every 3 weeks . | [{'class': 'POS', 'spans': ['ramucirumab', 'dacarbazine'], 'is_context_needed': True}] |
The aim of this study was to investigate the mutagenic and antigenotoxic effects of different doses of the flavonoid , apigenin , alone and in combination with the antitumor drugs , cyclophosphamide and doxorubicin , in vitro and in vivo . | [{'class': 'POS', 'spans': ['apigenin', 'doxorubicin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1], 'is_context_needed': True}] |
More effective regimens are urgently needed for squamous cell carcinoma of esophagus ( SCCE ) , therefore , we conducted a phase I/II trial of a combination of docetaxel , platinum , and fluorouracil ( TPF ) for treating metastatic SCCE . | [{'class': 'POS', 'spans': ['docetaxel', 'platinum'], 'is_context_needed': True}] |
Gemcitabine with cyclosporine or with tacrolimus exerts a synergistic effect and induces tolerance in the rat . | [{'class': 'POS', 'spans': ['Gemcitabine', 'cyclosporine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
We determined the effects of diclofenac sodium , octreotide , and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice . | [{'class': 'COMB', 'spans': ['diclofenac', 'octreotide'], 'is_context_needed': True}] |
Caspofungin and amphotericin B association has been shown to be synergistic in vitro and effective in murine models . | [{'class': 'POS', 'spans': ['Caspofungin', 'amphotericin'], 'is_context_needed': False}] |
Canine leishmaniosis is most frequently treated with the drugs meglumine antimoniate , allopurinol , amphotericin B , or a combination of meglumine antimoniate and allopurinol . | [{'class': 'POS', 'spans': ['meglumine', 'allopurinol'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2, 5], 'is_context_needed': False}] |
Haloperidol , carbamazepine and levomepromazine were then discontinued . | [{'class': 'COMB', 'spans': ['Haloperidol', 'carbamazepine'], 'is_context_needed': True}] |
Recent clinical work has questioned the safety of a combined therapy of oral quinidine and intravenous verapamil , because some patients were reported to react with severe hypotension probably due to drug interactions with vascular alpha-adrenergic receptors . | [{'class': 'NEG', 'spans': ['quinidine', 'verapamil'], 'is_context_needed': False}] |
To increase the dose-intensity of two drugs in metastatic breast cancer , we tested the feasibility , in phase I studies , of two schedules of epirubicin ( E ) and cyclophosphamide ( C ) - sequential ( E-- > C ) and alternating ( E/C ) - with respect to the standard combination ( EC ) . | [{'class': 'POS', 'spans': ['epirubicin', 'cyclophosphamide'], 'is_context_needed': True}] |
On February 3 , 2015 , the FDA granted accelerated approval to palbociclib ( IBRANCE , Pfizer Inc. ) , an inhibitor of cyclin-dependent kinases 4 and 6 ( CDK4 and CDK6 ) , for use in combination with letrozole for the treatment of postmenopausal women with estrogen receptor (ER)-positive , HER2-negative advanced breast cancer as initial endocrine-based therapy for their metastatic disease . | [{'class': 'POS', 'spans': ['palbociclib', 'letrozole'], 'is_context_needed': False}] |
a combination treatment : estramustine phosphate , cyproterone acetate or estrogens plus bromocriptine . | [{'class': 'POS', 'spans': ['estramustine', 'cyproterone'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
Hormone induced elevations in temperature and possibly other unidentified factors during thyroid crisis may facilitate the triggering of MH following halothane and succinylcholine challenge . | [{'class': 'COMB', 'spans': ['halothane', 'succinylcholine'], 'is_context_needed': True}] |
Mitomycin C plus vinblastine is an effective and well-tolerated regimen for anthracycline resistant cancer . | [{'class': 'POS', 'spans': ['Mitomycin', 'vinblastine'], 'is_context_needed': False}] |
An angiotensin 2 type 1 receptor blocker , olmesartan , and a calcium channel blocker , azelnidipine , possess not only an antihypertensive effect but also an antioxidative effect and other beneficial effects . | [{'class': 'POS', 'spans': ['olmesartan', 'azelnidipine'], 'is_context_needed': False}] |
Forty patients with metastatic breast cancer who had received no previous cytotoxic therapy were treated with a combination chemotherapy program CMF ( P ) , which included methotrexate , 60 mg/m2 , and 5-fluorouracil , 700 mg/m2 intravenously on the first and eighth days , in addition to cyclophosphamide , 100 mg/m2 , and prednisone , 40 mg/m2 , by mouth daily from the first to the fourteenth day of a 28-day cycle . | [{'class': 'POS', 'spans': ['methotrexate', 'cyclophosphamide', 'prednisone', '5-fluorouracil'], 'is_context_needed': True}] |
At present , it seems to us that progress has not been made since Grignani reported a phase II cohort trial of sorafenib and sorafenib combined with everolimus for advanced osteosarcoma , which , in a sense , have become a milestone as a second-line therapy for osteosarcoma . | [{'class': 'COMB', 'spans': ['sorafenib', 'everolimus'], 'is_context_needed': True}] |
Thirteen patients with interstitial cystitis diagnosed by the NIH criteria were treated with intravesical electromotive administration of lidocaine and dexamethasone followed by cystodistention . | [{'class': 'POS', 'spans': ['lidocaine', 'dexamethasone', 'cystodistention'], 'is_context_needed': True}] |
Drug therapy included omega-3 fish oil , extended-release niacin , colesevelam hydrochloride , and a fixed combination of 10-mg ezetimibe and 40-mg simvastatin . | [{'class': 'POS', 'spans': ['omega-3', 'niacin', 'colesevelam hydrochloride', 'ezetimibe', 'simvastatin'], 'is_context_needed': True}] |
Twenty-one Japanese colorectal cancer patients received intravenous FOLFIRI ( bolus irinotecan , folinic acid , and fluorouracil followed by 46-hour fluorouracil infusion ) followed by bevacizumab ( 5 mg/kg ) in Cycle 1 . | [{'class': 'COMB', 'spans': ['irinotecan', 'folinic acid', 'fluorouracil', 'fluorouracil', 'bevacizumab'], 'is_context_needed': True}] |
Patients received vinorelbine starting at 20 mg/m(2 ) ( to 25 mg/m(2 ) ) and carboplatin area under the curve ( AUC ) 2.5 in divided-doses , both given on Days 1 and 8 every 21-day cycle for up to 6 cycles or until disease progression . | [{'class': 'POS', 'spans': ['vinorelbine', 'carboplatin'], 'is_context_needed': True}] |
Dexamethasone exhibited the highest effect on paclitaxel anti-tumor activity , in a dose-dependent fashion . | [{'class': 'COMB', 'spans': ['Dexamethasone', 'paclitaxel'], 'is_context_needed': True}] |
We therefore explored the in vitro combination of amphotericin B with itraconazole against 14 clinical Aspergillus fumigatus isolates ( 9 itraconazole susceptible and 5 itraconazole resistant ) with a colorimetric broth microdilution checkerboard technique using two drug interaction models able to explore complicated patterns of interactions : the response surface analysis of Bliss independence and the isobolographic analysis of Loewe additivity zero interaction theories . | [{'class': 'POS', 'spans': ['amphotericin', 'itraconazole'], 'is_context_needed': True}] |
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