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A randomized clinical trial of adjuvant chemotherapy with doxorubicin , ifosfamide , and cisplatin followed by radiotherapy versus radiotherapy alone in patients with localized uterine sarcomas ( SARCGYN study ) . | [{'class': 'POS', 'spans': ['doxorubicin', 'ifosfamide', 'cisplatin'], 'is_context_needed': True}] |
Combination therapy with irinotecan ( CPT-11 ) , 5-fluorouracil ( 5-FU ) and leucovorin is widely used for the treatment of metastatic colorectal cancer . | [{'class': 'POS', 'spans': ['irinotecan', 'leucovorin', '5-fluorouracil'], 'is_context_needed': True}] |
Long-term safety and outcome of fludarabine , cyclophosphamide and mitoxantrone ( FCM ) regimen in previously untreated patients with advanced follicular lymphoma : 12 years follow-up of a phase 2 trial . | [{'class': 'POS', 'spans': ['fludarabine', 'cyclophosphamide', 'mitoxantrone'], 'is_context_needed': True}] |
After clinical improvement under vemurafenib monotherapy , four cycles of ipilimumab were additionally administered . | [{'class': 'POS', 'spans': ['vemurafenib', 'ipilimumab'], 'is_context_needed': True}] |
Bevacizumab plus paclitaxel versus bevacizumab plus capecitabine as first-line treatment for HER2-negative metastatic breast cancer ( TURANDOT ): primary endpoint results of a randomised , open-label , non-inferiority , phase 3 trial . | [{'class': 'POS', 'spans': ['bevacizumab', 'capecitabine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}] |
She underwent rectectomy and adjuvant chemotherapy with fluorouracil , leucovorin plus oxaliplatin for stage IIIB rectal cancer . | [{'class': 'COMB', 'spans': ['fluorouracil', 'leucovorin', 'oxaliplatin'], 'is_context_needed': True}] |
We designed this phase II trial to evaluate the safety , tolerability , and efficacy of the combination of carboplatin , paclitaxel , cetuximab , and bevacizumab in chemotherapy-naive patients with advanced , nonsquamous NSCLC . | [{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel', 'cetuximab', 'bevacizumab'], 'is_context_needed': True}] |
All patients underwent mexiletine monotherapy ( M-mono ) , propafenone monotherapy ( P-mono ) , low dose combination therapy ( low M+P ) , and full dose combination therapy ( full M+P ) . | [{'class': 'POS', 'spans': ['mexiletine', 'propafenone'], 'is_context_needed': True}] |
Cephalexin , 500 mg 4 times daily , plus trimethoprim-sulfamethoxazole , 320 mg/1600 mg twice daily , for 7 days ( n = 248 participants ) or cephalexin plus placebo for 7 days ( n = 248 participants ) . | [{'class': 'COMB', 'spans': ['Cephalexin', 'trimethoprim-sulfamethoxazole'], 'is_context_needed': True}] |
In the NALA trial , neratinib plus capecitabine led to increased PFS and time to intervention for central nervous system disease over the standard regimen of lapatinib plus capecitabine . | [{'class': 'POS', 'spans': ['neratinib', 'capecitabine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}] |
Since the patient had anemia , aspirin and cilostazol were discontinued after diagnosis . | [{'class': 'NEG', 'spans': ['aspirin', 'cilostazol'], 'is_context_needed': True}] |
This case report describes a patient with O-NHL which was possibly linked to the combination of methotrexate and etanercept for the treatment of her rheumatoid arthritis . | [{'class': 'NEG', 'spans': ['methotrexate', 'etanercept'], 'is_context_needed': False}] |
In a prospective , pragmatic , randomised , parallel group study , 170 patients of mean ( SD ) age 37 ( 12 ) years with acute asthma ( peak expiratory flow ( PEF ) 212 ( 80 ) l/min ) presenting to hospital received treatment with either high dose prednisolone and continuous nebulised salbutamol as recommended in the US or lower dose prednisolone and bolus nebulised salbutamol as recommended in the UK by the BTS . | [{'class': 'POS', 'spans': ['prednisolone', 'salbutamol'], 'is_context_needed': True}] |
We report a case of a 78-year-old white male ( weight , 90 kg ) presented to the Department of Medical Oncology and Hematology , Istituto Clinico Humanitas , Rozzano , Milan , Italy , with refractory MM immunoglobulin G kappa ( IgGkappa ) , Durie-Salmon Stage IIA , with progressive renal failure after an oral melphalan , prednisone , and thalidomide regimen ( 4 mg/m2.d , 40 mg/m2.d for 7 days every 6 weeks , and 100 mg/d , respectively ) . | [{'class': 'NEG', 'spans': ['melphalan', 'prednisone', 'thalidomide'], 'is_context_needed': False}] |
Following an intravitreal injection of ranibizumab , off-label administration of intravitreal dexamethasone was considered to reduce the edema . | [{'class': 'POS', 'spans': ['ranibizumab', 'dexamethasone'], 'is_context_needed': False}] |
We performed a prospective , preplanned , pooled analysis of six randomized , phase 3 trials that were conducted concurrently to evaluate the noninferiority of adjuvant therapy with either FOLFOX ( fluorouracil , leucovorin , and oxaliplatin ) or CAPOX ( capecitabine and oxaliplatin ) administered for 3 months , as compared with 6 months . | [{'class': 'POS', 'spans': ['capecitabine', 'oxaliplatin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1, 2], 'is_context_needed': True}] |
Growth inhibition and apoptosis were significantly ( P < 0.05 ) higher in BxPC-3 , HPAC , and PANC-1 cells treated with celecoxib and erlotinib than cells treated with either celecoxib or erlotinib . | [{'class': 'POS', 'spans': ['celecoxib', 'erlotinib'], 'is_context_needed': False}] |
These results indicate that low-dose 100 microg levonorgestrel and 20 microg ethinyl estradiol given for 21 days is effective in suppressing ovarian activity and they confirm the contraceptive efficacy observed in clinical trials ( Pearl index of 0.8 ) . | [{'class': 'POS', 'spans': ['levonorgestrel', 'ethinyl'], 'is_context_needed': False}] |
The combination of ixabepilone and capecitabine in the phase II study resulted in an ORR of 23 % in triple-negative patients . | [{'class': 'POS', 'spans': ['ixabepilone', 'capecitabine'], 'is_context_needed': True}] |
We report the rare case of a 27-year-old premenopausal woman with locally advanced breast cancer that was marked by rapid tumor necrosis followed by massive hemorrhage shortly after bevacizumab and paclitaxel administration . | [{'class': 'NEG', 'spans': ['bevacizumab', 'paclitaxel'], 'is_context_needed': False}] |
More recently , paclitaxel plus carboplatin also has been evaluated in previously untreated patients . | [{'class': 'COMB', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
Mitoxantrone and cyclophosphamide in advanced breast cancer : a pilot study . | [{'class': 'POS', 'spans': ['Mitoxantrone', 'cyclophosphamide'], 'is_context_needed': True}] |
We retrospectively analyzed the data of 37 patients who had postprandial hyperglycemia ( ≥10.0 mmol/L ) with BOT ( long-acting insulin plus glimepiride ) with their insulin titrated enough to keep preprandial glycemia < 7.2 mmol/L , and who had their treatment changed to liraglutide monotherapy , with the subsequent addition of glimepiride , when required . | [{'class': 'COMB', 'spans': ['liraglutide', 'glimepiride'], 'is_context_needed': True}] |
It was shown that the H2 receptor antagonist cimetidine when combined with N , N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl ( DPPE ) , a tamoxifen derivate , inhibits the proliferation of HT168 cells . | [{'class': 'POS', 'spans': ['cimetidine', 'DPPE', 'N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl'], 'is_context_needed': False}] |
We report here on a case of successful treatment of a patient suffering with severe liver dysfunction and metastatic gastric cancer ; the patient was treated with a combination of capecitabine and oxaliplatin ( XELOX ) . | [{'class': 'POS', 'spans': ['capecitabine', 'oxaliplatin'], 'is_context_needed': False}] |
From 1987 to 1991 , 194 previously untreated patients received vincristine and ifosfamide plus dactinomycin or etoposide for 1 - 2 years . | [{'class': 'NEG', 'spans': ['vincristine', 'ifosfamide', 'dactinomycin'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 1, 3], 'is_context_needed': True}] |
This nested substudy of the AVALON trial assessed the effects of coadministered amlodipine and atorvastatin vs. either therapy alone or placebo on arterial compliance , to evaluate the vascular benefits of coadministered therapy . | [{'class': 'POS', 'spans': ['amlodipine', 'atorvastatin'], 'is_context_needed': True}] |
We analysed the serial dermatoscopic photographs of atypical melanocytic lesions taken from patients with advanced metastatic melanoma on four different systemic therapies ( selective BRAF-inhibitor monotherapy , dabrafenib combined with trametinib [ D&T ] , anti-programmed cell death protein 1 [ anti-PD1 ] therapies , and anti-PD1 combined with ipilimumab ) seen from February 2013 to May 2016 . | [{'class': 'COMB', 'spans': ['dabrafenib', 'trametinib'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}] |
He received six cycles MOPP-induction therapy followed by a chlorambucil maintenance therapy with procarbazine and prednisone reinforcements . | [{'class': 'NEG', 'spans': ['chlorambucil', 'procarbazine', 'prednisone'], 'is_context_needed': True}] |
Frontline bortezomib and rituximab for the treatment of newly diagnosed high tumour burden indolent non-Hodgkin lymphoma : a multicentre phase II study . | [{'class': 'POS', 'spans': ['bortezomib', 'rituximab'], 'is_context_needed': True}] |
The ifosfamide , carboplatin and etoposide ( ICE ) regimen was developed to address these challenges . | [{'class': 'POS', 'spans': ['ifosfamide', 'carboplatin', 'etoposide'], 'is_context_needed': True}] |
Effect of sequential treatments with alendronate , parathyroid hormone ( 1 - 34 ) and raloxifene on cortical bone mass and strength in ovariectomized rats . | [{'class': 'POS', 'spans': ['alendronate', 'parathyroid hormone', 'raloxifene'], 'is_context_needed': True}] |
Atorvastatin and metformin both have pleiotropic effects . | [{'class': 'POS', 'spans': ['Atorvastatin', 'metformin'], 'is_context_needed': True}] |
Bevacizumab , a monoclonal antibody targeting vascular endothelial growth factor , is the first antiangiogenic drug to show improved efficacy when used in combination with irinotecan and oxaliplatin for first- and second-line treatment of CRC . | [{'class': 'POS', 'spans': ['Bevacizumab', 'irinotecan', 'oxaliplatin'], 'is_context_needed': False}] |
Between Oct 24 , 2016 , and Jan 24 , 2018 , 861 patients were randomly assigned to receive pembrolizumab plus axitinib ( n=432 ) or sunitinib monotherapy ( n=429 ) . | [{'class': 'POS', 'spans': ['pembrolizumab', 'axitinib'], 'is_context_needed': True}] |
Patients received 175 mg/m of paclitaxel over a 3 h infusion , followed by nedaplatin 80 mg/m in a 1 h infusion on day 1 every 3 weeks for up to 6 treatment cycles . | [{'class': 'POS', 'spans': ['paclitaxel', 'nedaplatin'], 'is_context_needed': True}] |
After a median follow-up of 9.5 years , 10-year OS rates in the bolus/infusional fluorouracil plus leucovorin ( LV5FU2 ) and LV5FU2 plus oxaliplatin ( FOLFOX4 ) arms were 67.1 % versus 71.7 % ( hazard ratio [ HR ] , 0.85 ; P = .043 ) in the whole population , 79.5 % versus 78.4 % for stage II ( HR , 1.00 ; P = .980 ) , and 59.0 % versus 67.1 % for stage III ( HR , 0.80 ; P = .016 ) disease . | [{'class': 'POS', 'spans': ['fluorouracil', 'leucovorin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
[ Effects of combined use of dofetilide and verapamil on the action potential of papillary muscles in guinea pigs ] . | [{'class': 'POS', 'spans': ['dofetilide', 'verapamil'], 'is_context_needed': True}] |
Patients with pancreatic adenocarcinoma , pre-treated with gemcitabine-based chemotherapy , were treated with capecitabine ( 800 mg/m(2 ) orally , twice a day for 14 days ) and docetaxel ( 75 mg/m(2 ) i.v , on day 1 ) , every 3 weeks . | [{'class': 'POS', 'spans': ['capecitabine', 'docetaxel'], 'is_context_needed': True}] |
Comparative study of dose escalation versus interval reduction to obtain dose-intensification of epirubicin and cyclophosphamide with granulocyte colony-stimulating factor in advanced breast cancer . | [{'class': 'POS', 'spans': ['epirubicin', 'cyclophosphamide'], 'is_context_needed': True}] |
The hearts were treated during the whole procedure either with vehicle , 0.5 μM flecainide ( sodium channel blocker ) or 100 μM streptomycin ( here used as stretch-activated ion-channel blocker ) . | [{'class': 'COMB', 'spans': ['flecainide', 'streptomycin'], 'is_context_needed': True}] |
In the APHINITY study ( NCT01358877 , BIG 4 - 11/BO25126/TOC4939 G ) , pertuzumab added to trastuzumab and chemotherapy significantly improved invasive disease-free survival as adjuvant treatment for patients with HER2-positive early breast cancer . | [{'class': 'POS', 'spans': ['pertuzumab', 'trastuzumab'], 'is_context_needed': False}] |
In two trials , an anti-EGFR antibody ( panitumumab or cetuximab ) reduced median survival when added to bevacizumab in previously untreated patients . | [{'class': 'NEG', 'spans': ['panitumumab', 'bevacizumab'], 'is_context_needed': False}, {'class': 'NEG', 'spans': [1, 2], 'is_context_needed': False}] |
The results of the APPEARANCE trial indicate that adapalene does not prevent acne-like rash over placebo when added to topical moisturizer and oral minocycline but instead may have a detrimental effect . | [{'class': 'NEG', 'spans': ['adapalene', 'minocycline'], 'is_context_needed': False}] |
Both regimens included cyclophosphamide , methotrexate , 5-FU , prednisone , and doxorubicin . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin'], 'is_context_needed': True}] |
A Randomized , Multicenter , Double-blind , Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis . | [{'class': 'POS', 'spans': ['Montelukast', 'Levocetirizine'], 'is_context_needed': True}] |
Intravenous administration of cefoperazone and sulbactam given as individual agents compared with the combination did not show pharmacokinetic differences that are likely to produce clinically relevant effects . | [{'class': 'COMB', 'spans': ['cefoperazone', 'sulbactam'], 'is_context_needed': True}] |
HDC with cyclophosphamide , carmustine and thiotepa was given from day -7 to -5 . | [{'class': 'COMB', 'spans': ['cyclophosphamide', 'carmustine', 'thiotepa'], 'is_context_needed': True}] |
A recently reported phase II trial has demonstrated that trastuzumab plus vinorelbine is both effective ( overall response rate 75 % ) and well tolerated , with the major side effects being typical of single-agent vinorelbine . | [{'class': 'POS', 'spans': ['trastuzumab', 'vinorelbine'], 'is_context_needed': False}] |
Differences were observed when palbociclib or ribociclib was used in combination with letrozole or anastrozole or fulvestrant . | [{'class': 'COMB', 'spans': ['palbociclib', 'letrozole'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 3], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 4], 'is_context_needed': True}] |
Resolution of muscle damage followed discontinuation of cyclosporine and lovastatin therapy . | [{'class': 'NEG', 'spans': ['cyclosporine', 'lovastatin'], 'is_context_needed': False}] |
Primary chemotherapy with gemcitabine , liposomal doxorubicin and docetaxel in patients with locally advanced breast cancer : results of a phase I trial . | [{'class': 'POS', 'spans': ['gemcitabine', 'doxorubicin', 'docetaxel'], 'is_context_needed': True}] |
The aim of this single-blind , randomized , controlled trial was to investigate treatment efficacy and safety of aripiprazole as an adjunct to valproic acid ( Ari+Val ) , compared with haloperidol plus valproic acid ( Hal+Val ) , in acute manic patients . | [{'class': 'POS', 'spans': ['aripiprazole', 'valproic'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
Because the incidence of nausea and vomiting is significantly reduced when ketorolac is used in place of opioids to attenuate postoperative pain , it would appear to be an appropriate choice of agent to use following propofol anesthesia . | [{'class': 'POS', 'spans': ['ketorolac', 'propofol'], 'is_context_needed': False}] |
The combination of vandetanib and bicalutamide was associated with considerable toxicity and did not have superior efficacy over bicalutamide alone . | [{'class': 'NEG', 'spans': ['vandetanib', 'bicalutamide'], 'is_context_needed': False}] |
Our data indicate that the addition of Aspirin or of Atenolol to Metformin might be beneficial for BC control , and that this activity is likely due to effects on both BC and microenvironment cells . | [{'class': 'POS', 'spans': ['Aspirin', 'Metformin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}] |
Coadministration of vorinostat and oxaliplatin induced G2/M phase arrest , triggered caspase-dependent apoptosis , and decreased tumorigenicity both in vitro and in vivo . | [{'class': 'POS', 'spans': ['vorinostat', 'oxaliplatin'], 'is_context_needed': False}] |
Randomized open trial of gentamicin and doxycycline for eradication of Bartonella quintana from blood in patients with chronic bacteremia . | [{'class': 'POS', 'spans': ['gentamicin', 'doxycycline'], 'is_context_needed': True}] |
The role of dual antiplatelet therapy combining aspirin and clopidogrel , is controversial . | [{'class': 'COMB', 'spans': ['aspirin', 'clopidogrel'], 'is_context_needed': True}] |
We conducted a dose-escalating study of daunorubicin combined to fixed doses of IM ( imatinib mesylate , 600 mg/d ) and cytarabine ( 200 mg/d for 7 days ) , followed by hematopoietic stem cell transplantation or maintenance therapy with single-agent IM in patients with MBC-CML at onset or after failure of therapy excluding TKIs . | [{'class': 'POS', 'spans': ['daunorubicin', 'imatinib', 'cytarabine'], 'is_context_needed': True}] |
[ Combination chemo-endocrine therapy of metastatic and stage IV breast cancer with cyclophosphamide , adriamycin , prednisolone and tamoxifen (CAPT)--with special reference to management of brain and liver metastasis ] . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'adriamycin', 'prednisolone', 'tamoxifen'], 'is_context_needed': True}] |
Ra ( rate of production ) was measured during infusion of variable doses of epinephrine with or without variable doses of propranolol , a competitive beta-adrenergic antagonist to isolate the alpha-adrenergic agonist effects . | [{'class': 'COMB', 'spans': ['epinephrine', 'propranolol'], 'is_context_needed': True}] |
A 29-year-old man with juvenile myoclonic epilepsy and medically refractory GTCS on a combination of levetiracetam and topiramate was started on lacosamide adjunctive therapy with the plan to replace topiramate . | [{'class': 'COMB', 'spans': ['levetiracetam', 'topiramate'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 2], 'is_context_needed': True}] |
[ A randomized controlled trial of immunochemotherapy using carmofur ( HCFU ) , mitomycin C and immunopotentiators in advanced gastric cancer following noncurative resection and nonresection ] . | [{'class': 'POS', 'spans': ['carmofur', 'mitomycin'], 'is_context_needed': True}] |
We thus undertook an extensive longitudinal immunologic study , including phenotypic , transcriptomic , and functional analyses , on 44 first-line and 27 relapsed/refractory patients enrolled in the GALEN trial ( Obinutuzumab Combined With Lenalidomide for Relapsed or Refractory Follicular B-Cell Lymphoma ) to test the efficacy of lenalidomide and obinutuzumab combination in patients with FL . | [{'class': 'COMB', 'spans': ['Obinutuzumab', 'Lenalidomide'], 'is_context_needed': True}] |
Nab-paclitaxel has demonstrated improved PFS and tolerability compared with standard cremophor-solubilized paclitaxel ; based on this , we examined the efficacy and safety of combining weekly nab-paclitaxel with carboplatin and bevacizumab in TNMBC . | [{'class': 'POS', 'spans': ['carboplatin', 'bevacizumab', 'nab-paclitaxel'], 'is_context_needed': True}] |
Acute renal failure ( ARF ) occurred concomitantly with the administration of gentamicin in combination with clindamycin in three patients in whom no other known predisposing cause of ARF could be demonstrated . | [{'class': 'NEG', 'spans': ['gentamicin', 'clindamycin'], 'is_context_needed': False}] |
To explore the role of augmenting neutrophil function in B-cell lymphoma , we conducted a phase II study evaluating the safety and clinical efficacy of pegfilgrastim and rituximab in low-grade CD20 | [{'class': 'POS', 'spans': ['pegfilgrastim', 'rituximab'], 'is_context_needed': True}] |
The aim of this paper is to compare intravitreous aflibercept versus dexamethasone implant followed by aflibercept ( sequential treatment group ) in patients with diabetic macular edema ( DME ) . | [{'class': 'POS', 'spans': ['dexamethasone', 'aflibercept'], 'is_context_needed': True}] |
Patients with advanced solid tumors received standard doses of paclitaxel and carboplatin on day 1 followed by either 0.1 mg/Kg or 0.2 mg/Kg CP-870,893 on day 3 ( Schedule A ) or day 8 ( Schedule B ) , repeated every 21 d. | [{'class': 'COMB', 'spans': ['paclitaxel', 'carboplatin', 'CP-870,893'], 'is_context_needed': True}] |
In a 52-week , open-label , multicenter , extension study , HDL-C , TG , and LDL-C levels continued to improve , or were maintained , during combination therapy with once-daily fenofibric acid 135 mg plus a moderate-dose statin ( atorvastatin 40 mg , rosuvastatin 20 mg , or simvastatin 40 mg ) . | [{'class': 'POS', 'spans': ['fenofibric', 'atorvastatin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': True}] |
To compare the safety and efficacy of 2 doses of lamivudine given in combination with zidovudine with continued zidovudine monotherapy . | [{'class': 'POS', 'spans': ['lamivudine', 'zidovudine'], 'is_context_needed': True}] |
Bradykinin enhanced the effect of carbachol by about 10 - 15 % . | [{'class': 'POS', 'spans': ['Bradykinin', 'carbachol'], 'is_context_needed': False}] |
Here , we report that combinatorial treatment using EGFRis , such as gefitinib or erlotinib , with PI3K/AKT pathway inhibitors ( PI3K/AKTis ) demonstrated a synergistic , anti-proliferative effect in cell lines of the basal-like ( BL ) subtype , a subtype of TNBC . | [{'class': 'POS', 'spans': ['gefitinib', 'PI3K/AKTis'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}] |
Patients received gemcitabine 1000 mg/m² intravenously on days 1 and 8 , capecitabine 1300 mg/m² oral daily from day 1 to 14 , and dovitinib oral daily 5 days on and 2 days off , every 21-day cycle . | [{'class': 'POS', 'spans': ['gemcitabine', 'capecitabine', 'dovitinib'], 'is_context_needed': False}] |
A reduced dose of oxaliplatin 105 mg/m(2 ) on day 1 with doxorubicin at 20 mg/m(2)/dose on days 1 - 3 was well tolerated . | [{'class': 'POS', 'spans': ['oxaliplatin', 'doxorubicin'], 'is_context_needed': True}] |
A total of 80 patients were randomized , including 44 to the combination group ( tamsulosin 0.4 mg and tolterodine early release 4 mg ) and 36 to the monotherapy group ( tamsulosin 0.4 mg and placebo ) . | [{'class': 'NEG', 'spans': ['tamsulosin', 'tolterodine'], 'is_context_needed': True}] |
Treatment of rapidly progressive glomerulonephritis by extracorporeal immunoadsorption , prednisolone and cyclophosphamide . | [{'class': 'COMB', 'spans': ['prednisolone', 'cyclophosphamide'], 'is_context_needed': True}] |
[ Doxifluridine , medroxyprogesterone acetate and cyclophosphamide ( DMpC ) combination therapy is effective against recurrent triple negative breast cancer -- a case report ] . | [{'class': 'POS', 'spans': ['Doxifluridine', 'medroxyprogesterone', 'cyclophosphamide'], 'is_context_needed': True}] |
The levels of 3 NF-kappaB transcription factors , the activating inhibitors of NF-kappaB ( IkappaB ) kinases , and the NF-kappaB target matrix metalloproteinase 9 ( MMP9 ) were assessed by immunohistochemistry in specimens of ovarian cancer that were obtained at diagnosis from a cohort of 33 patients who subsequently received combined paclitaxel , cisplatin , and cyclophosphamide . | [{'class': 'COMB', 'spans': ['paclitaxel', 'cyclophosphamide', 'cisplatin'], 'is_context_needed': True}] |
Randomized Phase II Trial of Seribantumab in Combination with Erlotinib in Patients with EGFR Wild-Type Non-Small Cell Lung Cancer . | [{'class': 'NEG', 'spans': ['Seribantumab', 'Erlotinib'], 'is_context_needed': True}] |
Trabectedin in combination with pegylated liposomal doxorubicin ( PLD ) has been fully available privately in the UK since 2009 for treating patients with ROC . | [{'class': 'POS', 'spans': ['Trabectedin', 'doxorubicin'], 'is_context_needed': True}] |
Estramustine has been shown to potentiate the antimicrotubule effects of vinblastine . | [{'class': 'COMB', 'spans': ['Estramustine', 'vinblastine'], 'is_context_needed': True}] |
Cohort 7 ( gemcitabine 600 mg/m/wk and carboplatin 2 AUC ) showed 4 dose limiting toxicities : 2 grade 3 esophagitis ; one grade 3 febrile neutropenia ; and one grade 4 neutropenia . | [{'class': 'COMB', 'spans': ['gemcitabine', 'carboplatin'], 'is_context_needed': True}] |
Treatment with IFN-α plus bevacizumab or standard targeted therapy ( sunitinib ) may lead to similar one-year overall mortality ( RR 0.37 , 95 % CI 0.13 to 1.08 ; 1 study ; 83 participants ; low-quality evidence ) and AEs of grade 3 or greater ( RR 1.18 , 95 % CI 0.85 to 1.62 ; 1 study ; 82 participants ; low-quality evidence ) . | [{'class': 'COMB', 'spans': ['bevacizumab', 'IFN-α'], 'is_context_needed': True}] |
The possibility that verapamil might increase the sensibility of colorectal carcinomas to doxorubicin was studied in 24 patients without previous cytotoxic chemotherapy . | [{'class': 'COMB', 'spans': ['verapamil', 'doxorubicin'], 'is_context_needed': True}] |
Twenty-six patients presenting with advanced breast cancer with a taxane- and vinorelbine-free line of chemotherapy were included and treated with vinorelbine ( 20 mg/m2 on D1 , D15 ) , followed by paclitaxel ( 175 mg/m2 on D1 ) , every 3 weeks . | [{'class': 'POS', 'spans': ['vinorelbine', 'paclitaxel'], 'is_context_needed': True}] |
Relationships between heart rate , exercise tolerance and cardiac output in atrial fibrillation : the effects of treatment with digoxin , verapamil and diltiazem . | [{'class': 'COMB', 'spans': ['digoxin', 'verapamil', 'diltiazem'], 'is_context_needed': True}] |
Oxaliplatin , which is effective for colorectal cancer ( CRC ) in combination with 5-fluorouracil ( 5-FU ) and leucovorin ( LV ) , is widely used for metastatic CRC . | [{'class': 'POS', 'spans': ['Oxaliplatin', 'leucovorin', '5-fluorouracil'], 'is_context_needed': True}] |
The cytotoxicity of sequential combinations of a taxoid [ paclitaxel ( TAX ) or docetaxel ( TXT ) ] with a vinca alkaloid [ vinorelbine ( NVB ) ] was compared in differentiated and undifferentiated HT29-D4 cells . | [{'class': 'COMB', 'spans': ['paclitaxel', 'vinorelbine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 2], 'is_context_needed': True}] |
Time to first deterioration was delayed with nivolumab + ipilimumab versus chemotherapy across LCSS and EQ-5D summary measures . | [{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': False}] |
In the present study , we investigated the effect atorvastatin , celecoxib and tipifarnib in combination on proliferation and apoptosis in Panc-1 sphere-forming cells . | [{'class': 'POS', 'spans': ['atorvastatin', 'celecoxib', 'tipifarnib'], 'is_context_needed': True}] |
Recipients received the dual endothelin-1 ( ET-1 ) receptor blocker , bosentan ( 100 mg/kg ) , the angiotensin-converting enzyme ( ACE ) inhibitor , ramipril ( 5 mg/kg ) , bosentan plus ramipril ( doses as just noted ) or vehicle . | [{'class': 'POS', 'spans': ['bosentan', 'ramipril'], 'is_context_needed': True}] |
After surgery , she received a sequential chemotherapy , ie , intraabdominal injection of carboplatin ( CBDCA 300 mg/m2 ) and div administration of paclitaxel ( PTX 180 mg/m2 ) as a standard regimen for advanced ovarian cancer . | [{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel'], 'is_context_needed': True}] |
To study the release of free endotoxin from Escherichia coli exposed to varying concentrations of the penicillin-binding protein ( PBP ) 3-specific beta-lactam antibiotic cefuroxime , the aminoglycoside tobramycin , and a combination of the two , and to test the relationship between bacterial killing rate and endotoxin release . | [{'class': 'POS', 'spans': ['cefuroxime', 'tobramycin'], 'is_context_needed': True}] |
As CDK7 inhibitors are currently under clinical evaluation in patients , our data suggest the addition of the TKI ponatinib or lapatinib in CDK7 inhibitor clinical trials in patients . | [{'class': 'POS', 'spans': ['lapatinib', 'CDK7 inhibitor'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
An effective treatment for operable breast cancer , NCT with epirubicin plus paclitaxel results in significant downstaging or eliminating of primary tumors in breast cancer , thus expanding the indication of breast conservation therapy . | [{'class': 'POS', 'spans': ['epirubicin', 'paclitaxel'], 'is_context_needed': False}] |
Carboplatin and etoposide for recurrent malignant glioma following surgical and radiotherapy failure : A clinical study conducted at the Northern Israel Oncology Center . | [{'class': 'NEG', 'spans': ['Carboplatin', 'etoposide'], 'is_context_needed': True}] |
ABC transporter inhibition plus dexamethasone enhances the efficacy of CED dasatinib , resulting in enhanced tumor cellular apoptosis and improved survival in H3.3K27 M mutant DIPG . | [{'class': 'POS', 'spans': ['dexamethasone', 'dasatinib'], 'is_context_needed': False}] |
Those who received prednisone alone could have mitoxantrone added after 6 weeks if there was no improvement in pain . | [{'class': 'POS', 'spans': ['prednisone', 'mitoxantrone'], 'is_context_needed': True}] |
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