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A randomized clinical trial of adjuvant chemotherapy with doxorubicin , ifosfamide , and cisplatin followed by radiotherapy versus radiotherapy alone in patients with localized uterine sarcomas ( SARCGYN study ) . | [{'class': 'POS', 'spans': ['doxorubicin', 'ifosfamide', 'cisplatin'], 'is_context_needed': True}] |
Combination therapy with irinotecan ( CPT-11 ) , 5-fluorouracil ( 5-FU ) and leucovorin is widely used for the treatment of metastatic colorectal cancer . | [{'class': 'POS', 'spans': ['irinotecan', 'leucovorin', '5-fluorouracil'], 'is_context_needed': True}] |
Long-term safety and outcome of fludarabine , cyclophosphamide and mitoxantrone ( FCM ) regimen in previously untreated patients with advanced follicular lymphoma : 12 years follow-up of a phase 2 trial . | [{'class': 'POS', 'spans': ['fludarabine', 'cyclophosphamide', 'mitoxantrone'], 'is_context_needed': True}] |
After clinical improvement under vemurafenib monotherapy , four cycles of ipilimumab were additionally administered . | [{'class': 'POS', 'spans': ['vemurafenib', 'ipilimumab'], 'is_context_needed': True}] |
Bevacizumab plus paclitaxel versus bevacizumab plus capecitabine as first-line treatment for HER2-negative metastatic breast cancer ( TURANDOT ): primary endpoint results of a randomised , open-label , non-inferiority , phase 3 trial . | [{'class': 'POS', 'spans': ['bevacizumab', 'capecitabine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}] |
She underwent rectectomy and adjuvant chemotherapy with fluorouracil , leucovorin plus oxaliplatin for stage IIIB rectal cancer . | [{'class': 'COMB', 'spans': ['fluorouracil', 'leucovorin', 'oxaliplatin'], 'is_context_needed': True}] |
We designed this phase II trial to evaluate the safety , tolerability , and efficacy of the combination of carboplatin , paclitaxel , cetuximab , and bevacizumab in chemotherapy-naive patients with advanced , nonsquamous NSCLC . | [{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel', 'cetuximab', 'bevacizumab'], 'is_context_needed': True}] |
All patients underwent mexiletine monotherapy ( M-mono ) , propafenone monotherapy ( P-mono ) , low dose combination therapy ( low M+P ) , and full dose combination therapy ( full M+P ) . | [{'class': 'POS', 'spans': ['mexiletine', 'propafenone'], 'is_context_needed': True}] |
Cephalexin , 500 mg 4 times daily , plus trimethoprim-sulfamethoxazole , 320 mg/1600 mg twice daily , for 7 days ( n = 248 participants ) or cephalexin plus placebo for 7 days ( n = 248 participants ) . | [{'class': 'COMB', 'spans': ['Cephalexin', 'trimethoprim-sulfamethoxazole'], 'is_context_needed': True}] |
In the NALA trial , neratinib plus capecitabine led to increased PFS and time to intervention for central nervous system disease over the standard regimen of lapatinib plus capecitabine . | [{'class': 'POS', 'spans': ['neratinib', 'capecitabine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}] |
Since the patient had anemia , aspirin and cilostazol were discontinued after diagnosis . | [{'class': 'NEG', 'spans': ['aspirin', 'cilostazol'], 'is_context_needed': True}] |
This case report describes a patient with O-NHL which was possibly linked to the combination of methotrexate and etanercept for the treatment of her rheumatoid arthritis . | [{'class': 'NEG', 'spans': ['methotrexate', 'etanercept'], 'is_context_needed': False}] |
In a prospective , pragmatic , randomised , parallel group study , 170 patients of mean ( SD ) age 37 ( 12 ) years with acute asthma ( peak expiratory flow ( PEF ) 212 ( 80 ) l/min ) presenting to hospital received treatment with either high dose prednisolone and continuous nebulised salbutamol as recommended in the US... | [{'class': 'POS', 'spans': ['prednisolone', 'salbutamol'], 'is_context_needed': True}] |
We report a case of a 78-year-old white male ( weight , 90 kg ) presented to the Department of Medical Oncology and Hematology , Istituto Clinico Humanitas , Rozzano , Milan , Italy , with refractory MM immunoglobulin G kappa ( IgGkappa ) , Durie-Salmon Stage IIA , with progressive renal failure after an oral melphalan... | [{'class': 'NEG', 'spans': ['melphalan', 'prednisone', 'thalidomide'], 'is_context_needed': False}] |
Following an intravitreal injection of ranibizumab , off-label administration of intravitreal dexamethasone was considered to reduce the edema . | [{'class': 'POS', 'spans': ['ranibizumab', 'dexamethasone'], 'is_context_needed': False}] |
We performed a prospective , preplanned , pooled analysis of six randomized , phase 3 trials that were conducted concurrently to evaluate the noninferiority of adjuvant therapy with either FOLFOX ( fluorouracil , leucovorin , and oxaliplatin ) or CAPOX ( capecitabine and oxaliplatin ) administered for 3 months , as com... | [{'class': 'POS', 'spans': ['capecitabine', 'oxaliplatin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1, 2], 'is_context_needed': True}] |
Growth inhibition and apoptosis were significantly ( P < 0.05 ) higher in BxPC-3 , HPAC , and PANC-1 cells treated with celecoxib and erlotinib than cells treated with either celecoxib or erlotinib . | [{'class': 'POS', 'spans': ['celecoxib', 'erlotinib'], 'is_context_needed': False}] |
These results indicate that low-dose 100 microg levonorgestrel and 20 microg ethinyl estradiol given for 21 days is effective in suppressing ovarian activity and they confirm the contraceptive efficacy observed in clinical trials ( Pearl index of 0.8 ) . | [{'class': 'POS', 'spans': ['levonorgestrel', 'ethinyl'], 'is_context_needed': False}] |
The combination of ixabepilone and capecitabine in the phase II study resulted in an ORR of 23 % in triple-negative patients . | [{'class': 'POS', 'spans': ['ixabepilone', 'capecitabine'], 'is_context_needed': True}] |
We report the rare case of a 27-year-old premenopausal woman with locally advanced breast cancer that was marked by rapid tumor necrosis followed by massive hemorrhage shortly after bevacizumab and paclitaxel administration . | [{'class': 'NEG', 'spans': ['bevacizumab', 'paclitaxel'], 'is_context_needed': False}] |
More recently , paclitaxel plus carboplatin also has been evaluated in previously untreated patients . | [{'class': 'COMB', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
Mitoxantrone and cyclophosphamide in advanced breast cancer : a pilot study . | [{'class': 'POS', 'spans': ['Mitoxantrone', 'cyclophosphamide'], 'is_context_needed': True}] |
We retrospectively analyzed the data of 37 patients who had postprandial hyperglycemia ( ≥10.0 mmol/L ) with BOT ( long-acting insulin plus glimepiride ) with their insulin titrated enough to keep preprandial glycemia < 7.2 mmol/L , and who had their treatment changed to liraglutide monotherapy , with the subsequent ad... | [{'class': 'COMB', 'spans': ['liraglutide', 'glimepiride'], 'is_context_needed': True}] |
It was shown that the H2 receptor antagonist cimetidine when combined with N , N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl ( DPPE ) , a tamoxifen derivate , inhibits the proliferation of HT168 cells . | [{'class': 'POS', 'spans': ['cimetidine', 'DPPE', 'N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl'], 'is_context_needed': False}] |
We report here on a case of successful treatment of a patient suffering with severe liver dysfunction and metastatic gastric cancer ; the patient was treated with a combination of capecitabine and oxaliplatin ( XELOX ) . | [{'class': 'POS', 'spans': ['capecitabine', 'oxaliplatin'], 'is_context_needed': False}] |
From 1987 to 1991 , 194 previously untreated patients received vincristine and ifosfamide plus dactinomycin or etoposide for 1 - 2 years . | [{'class': 'NEG', 'spans': ['vincristine', 'ifosfamide', 'dactinomycin'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 1, 3], 'is_context_needed': True}] |
This nested substudy of the AVALON trial assessed the effects of coadministered amlodipine and atorvastatin vs. either therapy alone or placebo on arterial compliance , to evaluate the vascular benefits of coadministered therapy . | [{'class': 'POS', 'spans': ['amlodipine', 'atorvastatin'], 'is_context_needed': True}] |
We analysed the serial dermatoscopic photographs of atypical melanocytic lesions taken from patients with advanced metastatic melanoma on four different systemic therapies ( selective BRAF-inhibitor monotherapy , dabrafenib combined with trametinib [ D&T ] , anti-programmed cell death protein 1 [ anti-PD1 ] therapies ,... | [{'class': 'COMB', 'spans': ['dabrafenib', 'trametinib'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}] |
He received six cycles MOPP-induction therapy followed by a chlorambucil maintenance therapy with procarbazine and prednisone reinforcements . | [{'class': 'NEG', 'spans': ['chlorambucil', 'procarbazine', 'prednisone'], 'is_context_needed': True}] |
Frontline bortezomib and rituximab for the treatment of newly diagnosed high tumour burden indolent non-Hodgkin lymphoma : a multicentre phase II study . | [{'class': 'POS', 'spans': ['bortezomib', 'rituximab'], 'is_context_needed': True}] |
The ifosfamide , carboplatin and etoposide ( ICE ) regimen was developed to address these challenges . | [{'class': 'POS', 'spans': ['ifosfamide', 'carboplatin', 'etoposide'], 'is_context_needed': True}] |
Effect of sequential treatments with alendronate , parathyroid hormone ( 1 - 34 ) and raloxifene on cortical bone mass and strength in ovariectomized rats . | [{'class': 'POS', 'spans': ['alendronate', 'parathyroid hormone', 'raloxifene'], 'is_context_needed': True}] |
Atorvastatin and metformin both have pleiotropic effects . | [{'class': 'POS', 'spans': ['Atorvastatin', 'metformin'], 'is_context_needed': True}] |
Bevacizumab , a monoclonal antibody targeting vascular endothelial growth factor , is the first antiangiogenic drug to show improved efficacy when used in combination with irinotecan and oxaliplatin for first- and second-line treatment of CRC . | [{'class': 'POS', 'spans': ['Bevacizumab', 'irinotecan', 'oxaliplatin'], 'is_context_needed': False}] |
Between Oct 24 , 2016 , and Jan 24 , 2018 , 861 patients were randomly assigned to receive pembrolizumab plus axitinib ( n=432 ) or sunitinib monotherapy ( n=429 ) . | [{'class': 'POS', 'spans': ['pembrolizumab', 'axitinib'], 'is_context_needed': True}] |
Patients received 175 mg/m of paclitaxel over a 3 h infusion , followed by nedaplatin 80 mg/m in a 1 h infusion on day 1 every 3 weeks for up to 6 treatment cycles . | [{'class': 'POS', 'spans': ['paclitaxel', 'nedaplatin'], 'is_context_needed': True}] |
After a median follow-up of 9.5 years , 10-year OS rates in the bolus/infusional fluorouracil plus leucovorin ( LV5FU2 ) and LV5FU2 plus oxaliplatin ( FOLFOX4 ) arms were 67.1 % versus 71.7 % ( hazard ratio [ HR ] , 0.85 ; P = .043 ) in the whole population , 79.5 % versus 78.4 % for stage II ( HR , 1.00 ; P = .980 ) ,... | [{'class': 'POS', 'spans': ['fluorouracil', 'leucovorin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
[ Effects of combined use of dofetilide and verapamil on the action potential of papillary muscles in guinea pigs ] . | [{'class': 'POS', 'spans': ['dofetilide', 'verapamil'], 'is_context_needed': True}] |
Patients with pancreatic adenocarcinoma , pre-treated with gemcitabine-based chemotherapy , were treated with capecitabine ( 800 mg/m(2 ) orally , twice a day for 14 days ) and docetaxel ( 75 mg/m(2 ) i.v , on day 1 ) , every 3 weeks . | [{'class': 'POS', 'spans': ['capecitabine', 'docetaxel'], 'is_context_needed': True}] |
Comparative study of dose escalation versus interval reduction to obtain dose-intensification of epirubicin and cyclophosphamide with granulocyte colony-stimulating factor in advanced breast cancer . | [{'class': 'POS', 'spans': ['epirubicin', 'cyclophosphamide'], 'is_context_needed': True}] |
The hearts were treated during the whole procedure either with vehicle , 0.5 μM flecainide ( sodium channel blocker ) or 100 μM streptomycin ( here used as stretch-activated ion-channel blocker ) . | [{'class': 'COMB', 'spans': ['flecainide', 'streptomycin'], 'is_context_needed': True}] |
In the APHINITY study ( NCT01358877 , BIG 4 - 11/BO25126/TOC4939 G ) , pertuzumab added to trastuzumab and chemotherapy significantly improved invasive disease-free survival as adjuvant treatment for patients with HER2-positive early breast cancer . | [{'class': 'POS', 'spans': ['pertuzumab', 'trastuzumab'], 'is_context_needed': False}] |
In two trials , an anti-EGFR antibody ( panitumumab or cetuximab ) reduced median survival when added to bevacizumab in previously untreated patients . | [{'class': 'NEG', 'spans': ['panitumumab', 'bevacizumab'], 'is_context_needed': False}, {'class': 'NEG', 'spans': [1, 2], 'is_context_needed': False}] |
The results of the APPEARANCE trial indicate that adapalene does not prevent acne-like rash over placebo when added to topical moisturizer and oral minocycline but instead may have a detrimental effect . | [{'class': 'NEG', 'spans': ['adapalene', 'minocycline'], 'is_context_needed': False}] |
Both regimens included cyclophosphamide , methotrexate , 5-FU , prednisone , and doxorubicin . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin'], 'is_context_needed': True}] |
A Randomized , Multicenter , Double-blind , Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis . | [{'class': 'POS', 'spans': ['Montelukast', 'Levocetirizine'], 'is_context_needed': True}] |
Intravenous administration of cefoperazone and sulbactam given as individual agents compared with the combination did not show pharmacokinetic differences that are likely to produce clinically relevant effects . | [{'class': 'COMB', 'spans': ['cefoperazone', 'sulbactam'], 'is_context_needed': True}] |
HDC with cyclophosphamide , carmustine and thiotepa was given from day -7 to -5 . | [{'class': 'COMB', 'spans': ['cyclophosphamide', 'carmustine', 'thiotepa'], 'is_context_needed': True}] |
A recently reported phase II trial has demonstrated that trastuzumab plus vinorelbine is both effective ( overall response rate 75 % ) and well tolerated , with the major side effects being typical of single-agent vinorelbine . | [{'class': 'POS', 'spans': ['trastuzumab', 'vinorelbine'], 'is_context_needed': False}] |
Differences were observed when palbociclib or ribociclib was used in combination with letrozole or anastrozole or fulvestrant . | [{'class': 'COMB', 'spans': ['palbociclib', 'letrozole'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 3], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 4], 'is_context_needed': True}] |
Resolution of muscle damage followed discontinuation of cyclosporine and lovastatin therapy . | [{'class': 'NEG', 'spans': ['cyclosporine', 'lovastatin'], 'is_context_needed': False}] |
Primary chemotherapy with gemcitabine , liposomal doxorubicin and docetaxel in patients with locally advanced breast cancer : results of a phase I trial . | [{'class': 'POS', 'spans': ['gemcitabine', 'doxorubicin', 'docetaxel'], 'is_context_needed': True}] |
The aim of this single-blind , randomized , controlled trial was to investigate treatment efficacy and safety of aripiprazole as an adjunct to valproic acid ( Ari+Val ) , compared with haloperidol plus valproic acid ( Hal+Val ) , in acute manic patients . | [{'class': 'POS', 'spans': ['aripiprazole', 'valproic'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
Because the incidence of nausea and vomiting is significantly reduced when ketorolac is used in place of opioids to attenuate postoperative pain , it would appear to be an appropriate choice of agent to use following propofol anesthesia . | [{'class': 'POS', 'spans': ['ketorolac', 'propofol'], 'is_context_needed': False}] |
The combination of vandetanib and bicalutamide was associated with considerable toxicity and did not have superior efficacy over bicalutamide alone . | [{'class': 'NEG', 'spans': ['vandetanib', 'bicalutamide'], 'is_context_needed': False}] |
Our data indicate that the addition of Aspirin or of Atenolol to Metformin might be beneficial for BC control , and that this activity is likely due to effects on both BC and microenvironment cells . | [{'class': 'POS', 'spans': ['Aspirin', 'Metformin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}] |
Coadministration of vorinostat and oxaliplatin induced G2/M phase arrest , triggered caspase-dependent apoptosis , and decreased tumorigenicity both in vitro and in vivo . | [{'class': 'POS', 'spans': ['vorinostat', 'oxaliplatin'], 'is_context_needed': False}] |
Randomized open trial of gentamicin and doxycycline for eradication of Bartonella quintana from blood in patients with chronic bacteremia . | [{'class': 'POS', 'spans': ['gentamicin', 'doxycycline'], 'is_context_needed': True}] |
The role of dual antiplatelet therapy combining aspirin and clopidogrel , is controversial . | [{'class': 'COMB', 'spans': ['aspirin', 'clopidogrel'], 'is_context_needed': True}] |
We conducted a dose-escalating study of daunorubicin combined to fixed doses of IM ( imatinib mesylate , 600 mg/d ) and cytarabine ( 200 mg/d for 7 days ) , followed by hematopoietic stem cell transplantation or maintenance therapy with single-agent IM in patients with MBC-CML at onset or after failure of therapy exclu... | [{'class': 'POS', 'spans': ['daunorubicin', 'imatinib', 'cytarabine'], 'is_context_needed': True}] |
[ Combination chemo-endocrine therapy of metastatic and stage IV breast cancer with cyclophosphamide , adriamycin , prednisolone and tamoxifen (CAPT)--with special reference to management of brain and liver metastasis ] . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'adriamycin', 'prednisolone', 'tamoxifen'], 'is_context_needed': True}] |
Ra ( rate of production ) was measured during infusion of variable doses of epinephrine with or without variable doses of propranolol , a competitive beta-adrenergic antagonist to isolate the alpha-adrenergic agonist effects . | [{'class': 'COMB', 'spans': ['epinephrine', 'propranolol'], 'is_context_needed': True}] |
A 29-year-old man with juvenile myoclonic epilepsy and medically refractory GTCS on a combination of levetiracetam and topiramate was started on lacosamide adjunctive therapy with the plan to replace topiramate . | [{'class': 'COMB', 'spans': ['levetiracetam', 'topiramate'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 2], 'is_context_needed': True}] |
[ A randomized controlled trial of immunochemotherapy using carmofur ( HCFU ) , mitomycin C and immunopotentiators in advanced gastric cancer following noncurative resection and nonresection ] . | [{'class': 'POS', 'spans': ['carmofur', 'mitomycin'], 'is_context_needed': True}] |
We thus undertook an extensive longitudinal immunologic study , including phenotypic , transcriptomic , and functional analyses , on 44 first-line and 27 relapsed/refractory patients enrolled in the GALEN trial ( Obinutuzumab Combined With Lenalidomide for Relapsed or Refractory Follicular B-Cell Lymphoma ) to test the... | [{'class': 'COMB', 'spans': ['Obinutuzumab', 'Lenalidomide'], 'is_context_needed': True}] |
Nab-paclitaxel has demonstrated improved PFS and tolerability compared with standard cremophor-solubilized paclitaxel ; based on this , we examined the efficacy and safety of combining weekly nab-paclitaxel with carboplatin and bevacizumab in TNMBC . | [{'class': 'POS', 'spans': ['carboplatin', 'bevacizumab', 'nab-paclitaxel'], 'is_context_needed': True}] |
Acute renal failure ( ARF ) occurred concomitantly with the administration of gentamicin in combination with clindamycin in three patients in whom no other known predisposing cause of ARF could be demonstrated . | [{'class': 'NEG', 'spans': ['gentamicin', 'clindamycin'], 'is_context_needed': False}] |
To explore the role of augmenting neutrophil function in B-cell lymphoma , we conducted a phase II study evaluating the safety and clinical efficacy of pegfilgrastim and rituximab in low-grade CD20 | [{'class': 'POS', 'spans': ['pegfilgrastim', 'rituximab'], 'is_context_needed': True}] |
The aim of this paper is to compare intravitreous aflibercept versus dexamethasone implant followed by aflibercept ( sequential treatment group ) in patients with diabetic macular edema ( DME ) . | [{'class': 'POS', 'spans': ['dexamethasone', 'aflibercept'], 'is_context_needed': True}] |
Patients with advanced solid tumors received standard doses of paclitaxel and carboplatin on day 1 followed by either 0.1 mg/Kg or 0.2 mg/Kg CP-870,893 on day 3 ( Schedule A ) or day 8 ( Schedule B ) , repeated every 21 d. | [{'class': 'COMB', 'spans': ['paclitaxel', 'carboplatin', 'CP-870,893'], 'is_context_needed': True}] |
In a 52-week , open-label , multicenter , extension study , HDL-C , TG , and LDL-C levels continued to improve , or were maintained , during combination therapy with once-daily fenofibric acid 135 mg plus a moderate-dose statin ( atorvastatin 40 mg , rosuvastatin 20 mg , or simvastatin 40 mg ) . | [{'class': 'POS', 'spans': ['fenofibric', 'atorvastatin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': True}] |
To compare the safety and efficacy of 2 doses of lamivudine given in combination with zidovudine with continued zidovudine monotherapy . | [{'class': 'POS', 'spans': ['lamivudine', 'zidovudine'], 'is_context_needed': True}] |
Bradykinin enhanced the effect of carbachol by about 10 - 15 % . | [{'class': 'POS', 'spans': ['Bradykinin', 'carbachol'], 'is_context_needed': False}] |
Here , we report that combinatorial treatment using EGFRis , such as gefitinib or erlotinib , with PI3K/AKT pathway inhibitors ( PI3K/AKTis ) demonstrated a synergistic , anti-proliferative effect in cell lines of the basal-like ( BL ) subtype , a subtype of TNBC . | [{'class': 'POS', 'spans': ['gefitinib', 'PI3K/AKTis'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}] |
Patients received gemcitabine 1000 mg/m² intravenously on days 1 and 8 , capecitabine 1300 mg/m² oral daily from day 1 to 14 , and dovitinib oral daily 5 days on and 2 days off , every 21-day cycle . | [{'class': 'POS', 'spans': ['gemcitabine', 'capecitabine', 'dovitinib'], 'is_context_needed': False}] |
A reduced dose of oxaliplatin 105 mg/m(2 ) on day 1 with doxorubicin at 20 mg/m(2)/dose on days 1 - 3 was well tolerated . | [{'class': 'POS', 'spans': ['oxaliplatin', 'doxorubicin'], 'is_context_needed': True}] |
A total of 80 patients were randomized , including 44 to the combination group ( tamsulosin 0.4 mg and tolterodine early release 4 mg ) and 36 to the monotherapy group ( tamsulosin 0.4 mg and placebo ) . | [{'class': 'NEG', 'spans': ['tamsulosin', 'tolterodine'], 'is_context_needed': True}] |
Treatment of rapidly progressive glomerulonephritis by extracorporeal immunoadsorption , prednisolone and cyclophosphamide . | [{'class': 'COMB', 'spans': ['prednisolone', 'cyclophosphamide'], 'is_context_needed': True}] |
[ Doxifluridine , medroxyprogesterone acetate and cyclophosphamide ( DMpC ) combination therapy is effective against recurrent triple negative breast cancer -- a case report ] . | [{'class': 'POS', 'spans': ['Doxifluridine', 'medroxyprogesterone', 'cyclophosphamide'], 'is_context_needed': True}] |
The levels of 3 NF-kappaB transcription factors , the activating inhibitors of NF-kappaB ( IkappaB ) kinases , and the NF-kappaB target matrix metalloproteinase 9 ( MMP9 ) were assessed by immunohistochemistry in specimens of ovarian cancer that were obtained at diagnosis from a cohort of 33 patients who subsequently r... | [{'class': 'COMB', 'spans': ['paclitaxel', 'cyclophosphamide', 'cisplatin'], 'is_context_needed': True}] |
Randomized Phase II Trial of Seribantumab in Combination with Erlotinib in Patients with EGFR Wild-Type Non-Small Cell Lung Cancer . | [{'class': 'NEG', 'spans': ['Seribantumab', 'Erlotinib'], 'is_context_needed': True}] |
Trabectedin in combination with pegylated liposomal doxorubicin ( PLD ) has been fully available privately in the UK since 2009 for treating patients with ROC . | [{'class': 'POS', 'spans': ['Trabectedin', 'doxorubicin'], 'is_context_needed': True}] |
Estramustine has been shown to potentiate the antimicrotubule effects of vinblastine . | [{'class': 'COMB', 'spans': ['Estramustine', 'vinblastine'], 'is_context_needed': True}] |
Cohort 7 ( gemcitabine 600 mg/m/wk and carboplatin 2 AUC ) showed 4 dose limiting toxicities : 2 grade 3 esophagitis ; one grade 3 febrile neutropenia ; and one grade 4 neutropenia . | [{'class': 'COMB', 'spans': ['gemcitabine', 'carboplatin'], 'is_context_needed': True}] |
Treatment with IFN-α plus bevacizumab or standard targeted therapy ( sunitinib ) may lead to similar one-year overall mortality ( RR 0.37 , 95 % CI 0.13 to 1.08 ; 1 study ; 83 participants ; low-quality evidence ) and AEs of grade 3 or greater ( RR 1.18 , 95 % CI 0.85 to 1.62 ; 1 study ; 82 participants ; low-quality e... | [{'class': 'COMB', 'spans': ['bevacizumab', 'IFN-α'], 'is_context_needed': True}] |
The possibility that verapamil might increase the sensibility of colorectal carcinomas to doxorubicin was studied in 24 patients without previous cytotoxic chemotherapy . | [{'class': 'COMB', 'spans': ['verapamil', 'doxorubicin'], 'is_context_needed': True}] |
Twenty-six patients presenting with advanced breast cancer with a taxane- and vinorelbine-free line of chemotherapy were included and treated with vinorelbine ( 20 mg/m2 on D1 , D15 ) , followed by paclitaxel ( 175 mg/m2 on D1 ) , every 3 weeks . | [{'class': 'POS', 'spans': ['vinorelbine', 'paclitaxel'], 'is_context_needed': True}] |
Relationships between heart rate , exercise tolerance and cardiac output in atrial fibrillation : the effects of treatment with digoxin , verapamil and diltiazem . | [{'class': 'COMB', 'spans': ['digoxin', 'verapamil', 'diltiazem'], 'is_context_needed': True}] |
Oxaliplatin , which is effective for colorectal cancer ( CRC ) in combination with 5-fluorouracil ( 5-FU ) and leucovorin ( LV ) , is widely used for metastatic CRC . | [{'class': 'POS', 'spans': ['Oxaliplatin', 'leucovorin', '5-fluorouracil'], 'is_context_needed': True}] |
The cytotoxicity of sequential combinations of a taxoid [ paclitaxel ( TAX ) or docetaxel ( TXT ) ] with a vinca alkaloid [ vinorelbine ( NVB ) ] was compared in differentiated and undifferentiated HT29-D4 cells . | [{'class': 'COMB', 'spans': ['paclitaxel', 'vinorelbine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 2], 'is_context_needed': True}] |
Time to first deterioration was delayed with nivolumab + ipilimumab versus chemotherapy across LCSS and EQ-5D summary measures . | [{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': False}] |
In the present study , we investigated the effect atorvastatin , celecoxib and tipifarnib in combination on proliferation and apoptosis in Panc-1 sphere-forming cells . | [{'class': 'POS', 'spans': ['atorvastatin', 'celecoxib', 'tipifarnib'], 'is_context_needed': True}] |
Recipients received the dual endothelin-1 ( ET-1 ) receptor blocker , bosentan ( 100 mg/kg ) , the angiotensin-converting enzyme ( ACE ) inhibitor , ramipril ( 5 mg/kg ) , bosentan plus ramipril ( doses as just noted ) or vehicle . | [{'class': 'POS', 'spans': ['bosentan', 'ramipril'], 'is_context_needed': True}] |
After surgery , she received a sequential chemotherapy , ie , intraabdominal injection of carboplatin ( CBDCA 300 mg/m2 ) and div administration of paclitaxel ( PTX 180 mg/m2 ) as a standard regimen for advanced ovarian cancer . | [{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel'], 'is_context_needed': True}] |
To study the release of free endotoxin from Escherichia coli exposed to varying concentrations of the penicillin-binding protein ( PBP ) 3-specific beta-lactam antibiotic cefuroxime , the aminoglycoside tobramycin , and a combination of the two , and to test the relationship between bacterial killing rate and endotoxin... | [{'class': 'POS', 'spans': ['cefuroxime', 'tobramycin'], 'is_context_needed': True}] |
As CDK7 inhibitors are currently under clinical evaluation in patients , our data suggest the addition of the TKI ponatinib or lapatinib in CDK7 inhibitor clinical trials in patients . | [{'class': 'POS', 'spans': ['lapatinib', 'CDK7 inhibitor'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
An effective treatment for operable breast cancer , NCT with epirubicin plus paclitaxel results in significant downstaging or eliminating of primary tumors in breast cancer , thus expanding the indication of breast conservation therapy . | [{'class': 'POS', 'spans': ['epirubicin', 'paclitaxel'], 'is_context_needed': False}] |
Carboplatin and etoposide for recurrent malignant glioma following surgical and radiotherapy failure : A clinical study conducted at the Northern Israel Oncology Center . | [{'class': 'NEG', 'spans': ['Carboplatin', 'etoposide'], 'is_context_needed': True}] |
ABC transporter inhibition plus dexamethasone enhances the efficacy of CED dasatinib , resulting in enhanced tumor cellular apoptosis and improved survival in H3.3K27 M mutant DIPG . | [{'class': 'POS', 'spans': ['dexamethasone', 'dasatinib'], 'is_context_needed': False}] |
Those who received prednisone alone could have mitoxantrone added after 6 weeks if there was no improvement in pain . | [{'class': 'POS', 'spans': ['prednisone', 'mitoxantrone'], 'is_context_needed': True}] |
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