bala1524/Drug_Combination_Extraction · Datasets at Hugging Face

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This is an investigator-initiated , multicenter randomized controlled trial ( RCT ) designed to compare the combination treatment of adalimumab and methotrexate with adalimumab monotherapy in patients with psoriasis .	[{'class': 'COMB', 'spans': ['adalimumab', 'methotrexate'], 'is_context_needed': True}]
These results provide compelling preclinical rationale indicating lapatinib to be a potentially efficacious chemotherapeutic combination partner for irinotecan in the treatment of gastrointestinal carcinomas .	[{'class': 'POS', 'spans': ['lapatinib', 'irinotecan'], 'is_context_needed': False}]
Women with previously untreated bulky ( primary tumor > /= 4 cm ) stage IB or IIA non-small-cell carcinoma of the uterine cervix were randomly assigned to receive either cisplatin 50 mg/m(2 ) and vincristine 1 mg/m(2 ) for 1 day and bleomycin 25 mg/m(2 ) for 3 days for three cycles followed by radical hysterectomy ( NAC arm ) or receive primary pelvic radiotherapy only ( R/T arm ) .	[{'class': 'COMB', 'spans': ['cisplatin', 'vincristine', 'bleomycin'], 'is_context_needed': True}]
The purpose of this study was to evaluate the efficacy of long-term use of bupropion sustained release ( SR ) , the nicotine patch , and the combination of these 2 treatments in patients who initially failed treatment .	[{'class': 'POS', 'spans': ['bupropion', 'nicotine'], 'is_context_needed': True}]
Systemic chemotherapy with vincristine , actinomycin D , plus cyclophosphamide ( VAC therapy ) , and etoposide plus cisplatin ( EP therapy ) were made according to Intergroup Rhabdomyosarcoma Study (IRS)-IV Regimen 45 .	[{'class': 'NEG', 'spans': ['vincristine', 'actinomycin D', 'cyclophosphamide', 'etoposide', 'cisplatin'], 'is_context_needed': True}]
He was asymptomatic half a year after the rituximab with cyclophosphamide , vincristine , doxorubicin , methotrexate/ifosfamide , etoposide , and high-dose cytarabine protocol therapy ; the lymphoma is in remission .	[{'class': 'POS', 'spans': ['rituximab', 'cyclophosphamide', 'vincristine', 'doxorubicin', 'methotrexate/ifosfamide', 'etoposide', 'cytarabine'], 'is_context_needed': False}]
To evaluate empiric nifuratel , amoxicillin , and bismuth triple therapy for H. pylori gastritis in childhood .	[{'class': 'POS', 'spans': ['nifuratel', 'amoxicillin', 'bismuth'], 'is_context_needed': True}]
The patient was treated in July 1998 with anthracycline , etoposide , and behenoyl cytarabine chemotherapy for AML ( French-American-British classification , M2 ; World Health Organization classification , AML with maturation ) and achieved complete remission .	[{'class': 'POS', 'spans': ['anthracycline', 'etoposide', 'behenoyl cytarabine'], 'is_context_needed': False}]
The risk increased when ASA was combined with clopidogrel , compared with aspirin alone ( OR , 1.86 ; 95 % CI , 1.49 - 2.31 ) , anticoagulants vs low doses of ASA alone ( OR , 1.93 ; 95 % CI , 1.42 - 2.61 ) , or in studies that included patients with a history of GI bleeding or of longer duration .	[{'class': 'NEG', 'spans': ['clopidogrel', 'ASA'], 'is_context_needed': False}]
Raloxifene , an anti-osteoporotic drug , is recently approved for prevention of breast cancer in postmenopausal women and thus the drug may be employed to combat the bony adverse effects of letrozole , another anticancer drug .	[{'class': 'POS', 'spans': ['Raloxifene', 'letrozole'], 'is_context_needed': True}]
In a previous trial , we found that adding the antiandrogen flutamide to leuprolide acetate ( a synthetic gonadotropin-releasing hormone that results in medical ablation of testicular function ) significantly improved survival as compared with that achieved with placebo plus leuprolide acetate .	[{'class': 'POS', 'spans': ['flutamide', 'leuprolide acetate'], 'is_context_needed': False}]
Contraceptives containing desogestrel or levonorgestrel have different effects on serum lipoproteins and post-heparin plasma lipase activities .	[{'class': 'COMB', 'spans': ['desogestrel', 'levonorgestrel'], 'is_context_needed': True}]
Concentrations of guaifenesin , diphenhydramine , and chlorpheniramine detected in the heart blood were 27.4 , 8.8 , and 0.2 mg/L , respectively .	[{'class': 'NEG', 'spans': ['guaifenesin', 'diphenhydramine', 'chlorpheniramine'], 'is_context_needed': True}]
The standard chemotherapy for localized ESFT now comprises vincristine , actinomycin D , cyclophosphamide and doxorubicin ( VACD ) in Europe or vincristine , doxorubicin , cyclophosphamide , ifosfamide and etoposide ( VDC-IE ) in North America .	[{'class': 'COMB', 'spans': ['vincristine', 'actinomycin D', 'cyclophosphamide', 'doxorubicin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [4, 5, 6, 7, 8], 'is_context_needed': True}]
Ceftriaxone plus gentamicin or ceftriaxone alone for streptococcal endocarditis in Japanese patients as alternative first-line therapies .	[{'class': 'NEG', 'spans': ['Ceftriaxone', 'gentamicin'], 'is_context_needed': True}]
Combined therapy : what does acamprosate and naltrexone combination tell us ?	[{'class': 'POS', 'spans': ['acamprosate', 'naltrexone'], 'is_context_needed': True}]
Reflecting the role of STAT3 in inducing localized immune suppression , using both atovaquone and pyrimethamine resulted in the modulation of immunoregulatory genes predicted to enhance an immune response , including upregulation of ICOSLG ( Inducible T-Cell Costimulator Ligand or B7H2 ) .	[{'class': 'POS', 'spans': ['atovaquone', 'pyrimethamine'], 'is_context_needed': False}]
TVR can be used in combination with tenofovir , emtricitabine and raltegravir for patients with hemophilia .	[{'class': 'POS', 'spans': ['tenofovir', 'emtricitabine', 'raltegravir', 'TVR'], 'is_context_needed': False}]
Topical therapy with azithromycin and oral therapy with doxycycline relieved signs and symptoms and restored the lipid properties of the meibomian gland secretion toward normal .	[{'class': 'POS', 'spans': ['azithromycin', 'doxycycline'], 'is_context_needed': False}]
Drug combinations , especially rapamycin + doxycycline may have promising anti-tumour effect in gliomas .	[{'class': 'POS', 'spans': ['rapamycin', 'doxycycline'], 'is_context_needed': False}]
Treatment with PUVA ( psoralen-ultraviolet-A ) combined with 40 - -80 mg prednisolone and then with chemotherapy [ COPP regimen ( cyclophosphamide , vincristine , procarbacine , prednisone ) , high-dosage methotrexate followed by citrovorum factor rescue ] was not successful .	[{'class': 'NEG', 'spans': ['prednisolone', 'cyclophosphamide', 'vincristine', 'prednisone', 'methotrexate', 'psoralen-ultraviolet-A', 'procarbacine', 'citrovorum'], 'is_context_needed': False}]
We evaluated a sequential treatment with Vinorelbine followed by Gemcitabine to determine its effect on survival and the toxicity in this patient population .	[{'class': 'POS', 'spans': ['Vinorelbine', 'Gemcitabine'], 'is_context_needed': True}]
Apoptosis in Hep2 cells treated with etoposide and colchicine .	[{'class': 'NEG', 'spans': ['etoposide', 'colchicine'], 'is_context_needed': True}]
The objective of this phase II study was to evaluate the efficacy and toxicity of carboplatin and weekly paclitaxel combination chemotherapy in previously untreated , advanced non-small cell lung cancer ( NSCLC ) .	[{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel'], 'is_context_needed': True}]
Therapy consisted of seven cycles of VCAP ( vincristine , cyclophosphamide , doxorubicin and prednisone ) , AMP ( doxorubicin , ranimustine and prednisone ) and VECP ( vindesine , etoposide , carboplatin and prednisone ) .	[{'class': 'POS', 'spans': ['vincristine', 'cyclophosphamide', 'doxorubicin', 'prednisone', 'doxorubicin', 'ranimustine', 'prednisone', 'etoposide', 'carboplatin', 'prednisone', 'vindesine'], 'is_context_needed': True}]
In HER2-amplified cells , the combination of trastuzumab and lapatinib was evaluated using the median effects principal .	[{'class': 'POS', 'spans': ['trastuzumab', 'lapatinib'], 'is_context_needed': True}]
Sorafenib monotherapy and combinations with taxanes , bevacizumab and ixabepilone showed inadequate efficacy , while efficacy results from combinations with gemcitabine and/or capecitabine and possibly tamoxifen were more promising .	[{'class': 'POS', 'spans': ['Sorafenib', 'gemcitabine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 4], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 5], 'is_context_needed': False}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]
This article reviews the pertinent studies regarding paclitaxel combined with cisplatin or carboplatin , discusses the remaining controversies surrounding how best to combine these agents , and provides opinions regarding the discordant outcomes noted in studies of the paclitaxel-platinum doublet .	[{'class': 'COMB', 'spans': ['paclitaxel', 'cisplatin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]
Hyperthermia could increase the sensitivity of SKOV3 to cis-platinum , carboplatin and oxaliplatin ( P < 0.05 ) .	[{'class': 'POS', 'spans': ['cis-platinum', 'Hyperthermia'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': False}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}]
A prospective phase 2 trial of short-course ( SC ) radiation therapy ( RT ) with 25 Gy over 5 fractions , followed by 4 cycles of 5-fluorouracil , oxaliplatin , and leucovorin ( mFOLFOX6 ) before surgery was recently completed at our institution .	[{'class': 'POS', 'spans': ['5-fluorouracil', 'oxaliplatin', 'leucovorin'], 'is_context_needed': True}]
[ A case of advanced gastric cancer successfully treated with trastuzumab , capecitabine , and Cisplatin therapy followed by curative resection ] .	[{'class': 'POS', 'spans': ['trastuzumab', 'capecitabine', 'Cisplatin'], 'is_context_needed': True}]
Sulpiride plus hydroxyzine decrease tinnitus perception .	[{'class': 'POS', 'spans': ['Sulpiride', 'hydroxyzine'], 'is_context_needed': False}]
We gave 2 , 3 , 5 and 5 mg/day/body of recombinant tissue plasminogen activator ( tPA ) followed by heparin and prostaglandin E1 ( PGE1 ) effectively and without significant side effect on days 9 , 10 , 13 and 14 , respectively .	[{'class': 'POS', 'spans': ['tissue plasminogen activator', 'heparin', 'prostaglandin E1'], 'is_context_needed': False}]
Roxithromycin and clarithromycin , 14-membered ring macrolides , potentiate the antitumor activity of cytotoxic agents against mouse B16 melanoma cells .	[{'class': 'POS', 'spans': ['Roxithromycin', 'clarithromycin'], 'is_context_needed': False}]
The EVA regimen ( etoposide , vinblastine , doxorubicin ) is an attempt to substitute a known active agent , etoposide , for bleomycin and dacarbazine .	[{'class': 'POS', 'spans': ['etoposide', 'vinblastine', 'doxorubicin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 2, 4, 5], 'is_context_needed': True}]
Carvedilol and imatinib mesylate alone reduced cell number , BrDU-LI , cAMP levels and spheroid volume .	[{'class': 'POS', 'spans': ['Carvedilol', 'imatinib'], 'is_context_needed': False}]
The recommended phase II dose ( RP2D ) was cytarabine 10 mg bid days 1 - 10 and sorafenib 600 mg/day days 2 - 28 .	[{'class': 'POS', 'spans': ['cytarabine', 'sorafenib'], 'is_context_needed': True}]
We performed a single-arm phase II trial of panitumumab in patients with KRAS wild-type metastatic colorectal cancer that had progressed on prior cetuximab .	[{'class': 'NEG', 'spans': ['panitumumab', 'cetuximab'], 'is_context_needed': True}]
Two Phase 1 studies assessed effects of ABT-450 ( 150 mg coadministered with ritonavir 100 mg once daily ) , ombitasvir ( 25 mg once daily ) , and dasabuvir ( 400 mg twice daily ) on the pharmacokinetics , safety , and tolerability of a single dose of cyclosporine ( 30 mg ) or tacrolimus ( 2 mg ) in healthy volunteers ( N = 12 per study ) .	[{'class': 'POS', 'spans': ['ABT-450', 'ritonavir', 'ombitasvir', 'dasabuvir', 'cyclosporine'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1, 2, 3, 5], 'is_context_needed': True}]
Antiplatelet therapy with dipyridamole , 100 mg q.i.d . , starting 2 days before surgery , followed by aspirin , 325 mg t.i.d . plus dipyridamole , 75 mg t.i.d . , 7 hours after surgery was assessed in the prevention of saphenous vein bypass graft occlusion .	[{'class': 'POS', 'spans': ['dipyridamole', 'aspirin', 'dipyridamole'], 'is_context_needed': True}]
Toxicity patterns following stepwise combinations of cyclophosphamide , methotrexate and fluorouracil .	[{'class': 'POS', 'spans': ['cyclophosphamide', 'methotrexate', 'fluorouracil'], 'is_context_needed': True}]
All patients were treated with the combination of lapatinib ( 1250 mg/day , continuously ) and capecitabine ( 2000 mg/m(2 ) on days 1 through 14 of a 21-day cycle ) .	[{'class': 'POS', 'spans': ['lapatinib', 'capecitabine'], 'is_context_needed': True}]
Effect of curcumin , a natural phytochemical in restoring doxorubicin sensitivity by targeting Aurora A was assessed furthermore .	[{'class': 'POS', 'spans': ['curcumin', 'doxorubicin'], 'is_context_needed': True}]
Our goals were to : establish the maximum-tolerated dose of olaparib tablets combined with metronomic carboplatin and paclitaxel in patients with relapsed high-grade serous ovarian cancer ; evaluate dose-limiting toxicities ; and evaluate efficacy at the maximum tolerated dose .	[{'class': 'POS', 'spans': ['olaparib', 'carboplatin', 'paclitaxel'], 'is_context_needed': True}]
All patients in this study were treated with decitabine of 15 mg/m2 for 5 days and G-CSF for priming , in combination with cytarabine of 10-mg/m2 q12h for 7 days and aclarubicin of 10 mg/day for 4 days ( D-CAG ) .	[{'class': 'POS', 'spans': ['decitabine', 'cytarabine', 'aclarubicin'], 'is_context_needed': True}]
Pertuzumab is the most recent agent approved by the US Food and Drug Administration in combination with trastuzumab and docetaxel for the treatment of patients with HER2(+ ) metastatic breast cancer who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease .	[{'class': 'POS', 'spans': ['Pertuzumab', 'trastuzumab', 'docetaxel'], 'is_context_needed': False}]
Safety and efficacy of sorafenib followed by regorafenib or lenvatinib in patients with hepatocellular carcinoma .	[{'class': 'COMB', 'spans': ['sorafenib', 'regorafenib'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]
The combination of boceprevir or telaprevir with peginterferon-alfa and ribavirin for the treatment of patients infected with HCV genotype 1 has led to significantly increased rates of sustained virological response ( SVR ) in phase III trials .	[{'class': 'POS', 'spans': ['boceprevir', 'peginterferon-alfa', 'ribavirin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 2, 3], 'is_context_needed': True}]
In contrast , the combination of plumbagin with AR antagonists , such as bicalutamide and enzalutamide , showed no improvement over AR antagonists alone .	[{'class': 'COMB', 'spans': ['bicalutamide', 'plumbagin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 2], 'is_context_needed': True}]
The B-cell lymphoma 2 ( BCL-2 ) inhibitor venetoclax has an emerging role in acute myeloid leukemia ( AML ) , with promising response rates in combination with hypomethylating agents or low-dose cytarabine in older patients .	[{'class': 'POS', 'spans': ['venetoclax', 'cytarabine'], 'is_context_needed': False}]
Combination chemotherapy with vincristine , bleomycin , and methotrexate for advanced head and neck cancers .	[{'class': 'NEG', 'spans': ['vincristine', 'bleomycin', 'methotrexate'], 'is_context_needed': True}]
Combination therapy with labetalol ( 400 mg/day ) and prazosin ( 6 mg/day ) was unsatisfactory , and the addition of long-acting nifedipine ( 40 mg/day ) produced a marked decrease in blood pressure .	[{'class': 'NEG', 'spans': ['labetalol', 'prazosin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 1, 2], 'is_context_needed': False}]
It was identified as C. lunata ( Wakker ) Boedijn var . aeria ( Batista , Lima and Vasconcelos ) Ellis ( IMI 253204 ) and its growth was better at 28 degrees C than at 37 degrees C. In vitro , the fungus was most sensitive to amphotericin B followed by miconazole nitrate , clotrimazole and triphenyltin isoselenocyanate 4-picoline which had the same activity .	[{'class': 'POS', 'spans': ['amphotericin', 'miconazole', 'clotrimazole', 'triphenyltin isoselenocyanate 4-picoline'], 'is_context_needed': False}]
Conclusions Everolimus plus mFOLFOX-6 + bevacizumab is tolerable and demonstrated preliminary efficacy for first-line mCRC .	[{'class': 'POS', 'spans': ['Everolimus', 'bevacizumab', 'mFOLFOX-6'], 'is_context_needed': False}]
We conducted a prospective phase II study to determine the response rate , toxicity , and survival rate of concurrent weekly paclitaxel , carboplatin , and hyperfractionated radiation therapy ( paclitaxel/carboplatin/HFX RT ) followed by 2 cycles of paclitaxel and carboplatin for locally advanced unresectable non-small cell lung cancer ( NSCLC ) .	[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]
A phase Ib study of pertuzumab , a recombinant humanised antibody to HER2 , and docetaxel in patients with advanced solid tumours .	[{'class': 'POS', 'spans': ['pertuzumab', 'docetaxel'], 'is_context_needed': True}]
These data suggest that vorinostat and doxorubicin may induce procoagulant activity in vessels through apoptosis of tumor cells and through phosphatidylserine exposure and/or tissue factor expression on vascular endothelial cells .	[{'class': 'NEG', 'spans': ['vorinostat', 'doxorubicin'], 'is_context_needed': True}]
Based on encouraging results of previous combination regimens , we used a combination of VM26 , ifosfamide , methyl GAG , mitoxantrone ( or adriamycin ) , high-dose ( HD ) methotrexate and HD Ara C to treat 18 patients with relapsed or refractory NHL .	[{'class': 'POS', 'spans': ['VM26', 'ifosfamide', 'methyl GAG ,', 'mitoxantrone', 'methotrexate', 'Ara C'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1, 2, 4, 5, 6], 'is_context_needed': True}]
We treated this patient with six cycles of CHOEP ( Cyclophosphamide , Doxorubicin , Vincristine , Etoposide , and Prednisone ) chemotherapy .	[{'class': 'POS', 'spans': ['Cyclophosphamide', 'Doxorubicin', 'Vincristine', 'Etoposide', 'Prednisone'], 'is_context_needed': True}]
One study evaluated gemcitabine with gemcitabine and pertuzumab .	[{'class': 'NEG', 'spans': ['gemcitabine', 'pertuzumab'], 'is_context_needed': True}]
We conclude that the combination of thiotepa , 5FU , and leucovorin had significant myelotoxicity and do not recommend its routine use in the treatment of metastatic breast cancer .	[{'class': 'NEG', 'spans': ['thiotepa', '5FU', 'leucovorin'], 'is_context_needed': False}]
Forty-two patients with stage III to IV resectable HNSCC and nasopharyngeal tumors received induction chemotherapy with two courses of cisplatin ( 20 mg/m2/d continuous infusion [ CI ] ) , fluorouracil ( 800 mg/m2/d CI ) , and leucovorin ( 500 mg/m2/d CI ; PFL ) for 4 days followed by concurrent therapy with cisplatin ( 100 mg/m2/d on days 1 and 22 ) and approximately 70 Gy of external-beam radiotherapy .	[{'class': 'POS', 'spans': ['cisplatin', 'fluorouracil', 'leucovorin'], 'is_context_needed': True}]
Will a combination of l-leucine with low-dose metformin and sildenafil produce a novel synergistic interaction that reduces body weight ?	[{'class': 'POS', 'spans': ['l-leucine', 'metformin', 'sildenafil'], 'is_context_needed': True}]
Combinatory activity of linezolid and levofloxacin with antituberculosis drugs in Mycobacterium tuberculosis .	[{'class': 'POS', 'spans': ['linezolid', 'levofloxacin'], 'is_context_needed': True}]
Canadian clinical guidelines recommend the use of the combination of tamsulosin and dutasteride for men with moderate/severe symptoms associated with BPH and enlarged prostate volume .	[{'class': 'POS', 'spans': ['tamsulosin', 'dutasteride'], 'is_context_needed': False}]
The present study was designed to test the effects of chronic combined treatment with low doses of an angiotensin converting enzyme inhibitor ( perindopril ) and of the diuretic indapamide in spontaneously hypertensive rats ( SHR ) .	[{'class': 'POS', 'spans': ['perindopril', 'indapamide'], 'is_context_needed': True}]
A phase 3 trial of azacitidine versus a semi-intensive fludarabine and cytarabine schedule in older patients with untreated acute myeloid leukemia .	[{'class': 'NEG', 'spans': ['fludarabine', 'cytarabine'], 'is_context_needed': True}]
Five other treatments closely followed ( dabrafenib [ HR PFS : 0.30 ] , nivolumab plus ipilimumab [ HR PFS : 0.34 ] , vemurafenib [ HR PFS : 0.38 ] , nivolumab [ HR PFS : 0.42 ] and pembrolizumab [ HR PFS : 0.46 ] ) .	[{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': True}]
Patients with newly diagnosed , locally advanced stage III or IV SCCHN received 4 weekly doses of carboplatin ( area under the curve , 1.5 ) and paclitaxel ( 45 mg/m(2 ) ) concurrently with concomitant boost radiation consisting of 72 grays in 42 fractions over 6 weeks ( every day for 18 days , twice a day for 12 days ) ( grading determined according to the TNM staging system ) .	[{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel'], 'is_context_needed': True}]
Phase 1b trial of docetaxel , prednisone , and pazopanib in men with metastatic castration-resistant prostate cancer .	[{'class': 'POS', 'spans': ['docetaxel', 'prednisone', 'pazopanib'], 'is_context_needed': True}]
Growth inhibition of cloned promastigotes showed that the films have enough releasing capacity and in vivo system , the films containing paromomycin and gentamicin was able to reduce the lesion size and induced complete cure in 80 % of the mice but relapse was seen in 60 % of the cured mice and overall 50 % cure rate was seen during 20 weeks period of the study .	[{'class': 'POS', 'spans': ['paromomycin', 'gentamicin'], 'is_context_needed': False}]
Management and outcome : The patient was initially treated with bortezomib and dexamethasone for the myeloma .	[{'class': 'COMB', 'spans': ['bortezomib', 'dexamethasone'], 'is_context_needed': True}]
We retrospectively evaluated 52 metastatic renal cell carcinoma patients who were treated with nivolumab plus ipilimumab between August 2015 and January 2020 .	[{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': True}]
Microdialysis-based pharmacokinetic studies demonstrated that administration of the P-gp inhibitor cyclosporin A resulted in increased brain levels of escitalopram without altering plasma escitalopram levels in the rat , thereby showing that P-gp restricts escitalopram transport across the blood-brain barrier ( BBB ) in vivo .	[{'class': 'POS', 'spans': ['cyclosporin', 'escitalopram'], 'is_context_needed': False}]
The combination of mezlocillin and an aminoglycoside produced synergy more often than did carbenicillin plus an aminoglycoside .	[{'class': 'POS', 'spans': ['mezlocillin', 'aminoglycoside'], 'is_context_needed': False}, {'class': 'COMB', 'spans': [1, 3], 'is_context_needed': True}]
Eligible patients ( n = 17 ) were divided into 2 groups receiving a combined chemotherapy of intravenous cisplatinum ( 70 mg/m2 ) and cyclophosphamide ( 700 mg/m2 ) with or without the addition of Lenograstim .	[{'class': 'POS', 'spans': ['cisplatinum', 'cyclophosphamide', 'Lenograstim'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}]
Ifosfamide at 12 g/m2 was administered by intravenous continuous infusion over 3 days , and doxorubicin 60 mg/m2 was administered as an intravenous bolus injection on day 1 .	[{'class': 'POS', 'spans': ['Ifosfamide', 'doxorubicin'], 'is_context_needed': True}]
A Randomized , Double-blind , Placebo-controlled Trial of Celecoxib Augmentation of Sertraline in Treatment of Drug-naive Depressed Women : A Pilot Study .	[{'class': 'POS', 'spans': ['Celecoxib', 'Sertraline'], 'is_context_needed': True}]
In seven patients with type B insulin resistance , standardized treatment with rituximab , cyclophosphamide , and pulse steroids results in remission of the disease .	[{'class': 'POS', 'spans': ['rituximab', 'cyclophosphamide', 'steroids'], 'is_context_needed': False}]
The purpose of this study was to determine the fertility rates following treatment by means of the BEACOPP regimen ( regular and escalated ) ( bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , prednisone ) as compared to the ABVD regimen ( doxorubicin , vinblastine , dacarbazine , bleomycin ) in Hodgkin lymphoma patients under the age of 40 at the time of treatment .	[{'class': 'POS', 'spans': ['bleomycin', 'etoposide', 'doxorubicin', 'cyclophosphamide', 'vincristine', 'procarbazine', 'prednisone'], 'is_context_needed': True}, {'class': 'POS', 'spans': [8, 9, 10, 7], 'is_context_needed': True}]
The positive inotropism of DPDPE was abrogated in animals pretreated with propranolol , CGRP(8 - 37 ) , or combined propranolol+CGRP(8 - 37 ) .	[{'class': 'COMB', 'spans': ['DPDPE', 'propranolol'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1, 2], 'is_context_needed': True}]
A case of Scedosporium apiospermum infection after BMT , treated initially with amphotericin B ( total dose of 2.5 g ) and then with itraconazole ( for 25 days ) , is reported here .	[{'class': 'NEG', 'spans': ['amphotericin', 'itraconazole'], 'is_context_needed': True}]
Thymidine Phosphorylase/β-tubulin III expressions predict the response in Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel .	[{'class': 'COMB', 'spans': ['capecitabine', 'paclitaxel'], 'is_context_needed': True}]
Modeling of the pharmacokinetic/pharmacodynamic interaction between irbesartan and hydrochlorothiazide in normotensive subjects .	[{'class': 'COMB', 'spans': ['irbesartan', 'hydrochlorothiazide'], 'is_context_needed': True}]
In Group IV , the augmentation of Pdi by olprinone was abolished in the fatigued diaphragm with an infusion of nicardipine .	[{'class': 'NEG', 'spans': ['olprinone', 'nicardipine'], 'is_context_needed': False}]
In a 71 years-old patient , a severe therapy-resistant depressive episode without psychotic symptoms was successfully treated by a combination of paroxetine and risperidone .	[{'class': 'POS', 'spans': ['paroxetine', 'risperidone'], 'is_context_needed': False}]
While there is no standard of care for PBL , current recommendations include dose-adjusted EPOCH ( etoposide , vincristine , doxorubicin , cyclophosphamide , and prednisone ) , with or without bortezomib .	[{'class': 'POS', 'spans': ['etoposide', 'vincristine', 'doxorubicin', 'cyclophosphamide', 'prednisone'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 1, 2, 3, 4, 5], 'is_context_needed': False}]
Our report of a patient with severe tardive dyskinesia ( TD ) who has been exposed to both typical antipsychotic and clozapine , olanzapine and quetiapine during a 124-week follow-up period supports the possible beneficial effect of atypical antipsychotics on pre-existing symptoms of TD .	[{'class': 'POS', 'spans': ['clozapine', 'olanzapine', 'quetiapine'], 'is_context_needed': False}]
Paclitaxel plus bevacizumab in patients with chemosensitive relapsed small cell lung cancer : a safety , feasibility , and efficacy study from the Hoosier Oncology Group .	[{'class': 'NEG', 'spans': ['Paclitaxel', 'bevacizumab'], 'is_context_needed': True}]
Significantly , genes regulated by both formoterol and budesonide were overrepresented in the genome ; moreover , budesonide-plus-formoterol induced and repressed 609 and 577 mRNAs , respectively , of which ~1/3 failed the cut-off criterion for either treatment alone .	[{'class': 'POS', 'spans': ['formoterol', 'budesonide'], 'is_context_needed': True}]
This study aimed to investigate the therapeutic responses of lung cancer mice models with adenocarcinoma HCC827 ( gefitinib sensitive ) and HCC827R ( gefitinib resistant ) to the epidermal growth factor receptor-tyrosine kinase inhibitor erlotinib alone and in combination with the anti-angiogenesis agent bevacizumab using dynamic contrast enhanced ( DCE ) and diffusion-weighted MRI .	[{'class': 'POS', 'spans': ['gefitinib', 'erlotinib'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2, 3], 'is_context_needed': True}]
, olmesartan medoxomil + amlodipine + HCTZ was more effective in reducing BP and achieving BP goals than each of the dual therapies , irrespective of hypertension severity , age , sex , race or diabetes mellitus status .	[{'class': 'POS', 'spans': ['olmesartan medoxomil', 'amlodipine', 'HCTZ'], 'is_context_needed': False}]
Multiple-dose pharmacokinetics of telmisartan and of hydrochlorothiazide following concurrent administration in healthy subjects .	[{'class': 'POS', 'spans': ['telmisartan', 'hydrochlorothiazide'], 'is_context_needed': True}]
The objective of the current study was to determine whether adding the mammalian target of rapamycin inhibitor temsirolimus to sorafenib could improve on these results .	[{'class': 'POS', 'spans': ['temsirolimus', 'sorafenib'], 'is_context_needed': True}]
The authors report the case of a 4-year-old boy with a diagnosis of stage IV neuroblastoma ( NB ) , who had been treated with 6 cycles of cyclophosphamide , doxorubicin , cisplatin , and etoposide for 12 months .	[{'class': 'COMB', 'spans': ['cyclophosphamide', 'doxorubicin', 'cisplatin', 'etoposide'], 'is_context_needed': True}]
Due to dose-limiting toxicity ( DLT ) in both patients ( elevated transaminases and thrombocytopenia ) , an additional three patients were treated on dose level -1 with trabectedin 0.7 mg/m2 plus gemcitabine 700 mg/m2 .	[{'class': 'NEG', 'spans': ['trabectedin', 'gemcitabine'], 'is_context_needed': True}]
He accepted surgical resection with followed multi-agent chemotherapy , containing vincristine , doxorubicin , ifosfamide and etoposide .	[{'class': 'POS', 'spans': ['vincristine', 'doxorubicin', 'ifosfamide', 'etoposide'], 'is_context_needed': True}]
The gemcitabine and mitoxantrone regimen was feasible to administer even in heavily pre-treated patients .	[{'class': 'POS', 'spans': ['gemcitabine', 'mitoxantrone'], 'is_context_needed': False}]
The aim of this study was to evaluate four phytocompounds ( cinnamaldehyde , citral , eugenol and geraniol ) for their in vitro inhibitory activity against pre-formed biofilms of Candida albicans alone or in combination with fluconazole and amphotericin B. These compounds were also tested at subinhibitory concentrations for their ability to inhibit biofilm formation .	[{'class': 'POS', 'spans': ['cinnamaldehyde', 'fluconazole'], 'is_context_needed': True}]
Neoadjuvant trastuzumab , pertuzumab , and chemotherapy versus trastuzumab emtansine plus pertuzumab in patients with HER2-positive breast cancer ( KRISTINE ): a randomised , open-label , multicentre , phase 3 trial .	[{'class': 'POS', 'spans': ['trastuzumab', 'pertuzumab', 'trastuzumab emtansine', 'pertuzumab'], 'is_context_needed': True}]

This is an investigator-initiated , multicenter randomized controlled trial ( RCT ) designed to compare the combination treatment of adalimumab and methotrexate with adalimumab monotherapy in patients with psoriasis .

[{'class': 'COMB', 'spans': ['adalimumab', 'methotrexate'], 'is_context_needed': True}]

These results provide compelling preclinical rationale indicating lapatinib to be a potentially efficacious chemotherapeutic combination partner for irinotecan in the treatment of gastrointestinal carcinomas .

[{'class': 'POS', 'spans': ['lapatinib', 'irinotecan'], 'is_context_needed': False}]

Women with previously untreated bulky ( primary tumor > /= 4 cm ) stage IB or IIA non-small-cell carcinoma of the uterine cervix were randomly assigned to receive either cisplatin 50 mg/m(2 ) and vincristine 1 mg/m(2 ) for 1 day and bleomycin 25 mg/m(2 ) for 3 days for three cycles followed by radical hysterectomy ( NAC arm ) or receive primary pelvic radiotherapy only ( R/T arm ) .

[{'class': 'COMB', 'spans': ['cisplatin', 'vincristine', 'bleomycin'], 'is_context_needed': True}]

The purpose of this study was to evaluate the efficacy of long-term use of bupropion sustained release ( SR ) , the nicotine patch , and the combination of these 2 treatments in patients who initially failed treatment .

[{'class': 'POS', 'spans': ['bupropion', 'nicotine'], 'is_context_needed': True}]

Systemic chemotherapy with vincristine , actinomycin D , plus cyclophosphamide ( VAC therapy ) , and etoposide plus cisplatin ( EP therapy ) were made according to Intergroup Rhabdomyosarcoma Study (IRS)-IV Regimen 45 .

[{'class': 'NEG', 'spans': ['vincristine', 'actinomycin D', 'cyclophosphamide', 'etoposide', 'cisplatin'], 'is_context_needed': True}]

He was asymptomatic half a year after the rituximab with cyclophosphamide , vincristine , doxorubicin , methotrexate/ifosfamide , etoposide , and high-dose cytarabine protocol therapy ; the lymphoma is in remission .

[{'class': 'POS', 'spans': ['rituximab', 'cyclophosphamide', 'vincristine', 'doxorubicin', 'methotrexate/ifosfamide', 'etoposide', 'cytarabine'], 'is_context_needed': False}]

To evaluate empiric nifuratel , amoxicillin , and bismuth triple therapy for H. pylori gastritis in childhood .

[{'class': 'POS', 'spans': ['nifuratel', 'amoxicillin', 'bismuth'], 'is_context_needed': True}]

The patient was treated in July 1998 with anthracycline , etoposide , and behenoyl cytarabine chemotherapy for AML ( French-American-British classification , M2 ; World Health Organization classification , AML with maturation ) and achieved complete remission .

[{'class': 'POS', 'spans': ['anthracycline', 'etoposide', 'behenoyl cytarabine'], 'is_context_needed': False}]

The risk increased when ASA was combined with clopidogrel , compared with aspirin alone ( OR , 1.86 ; 95 % CI , 1.49 - 2.31 ) , anticoagulants vs low doses of ASA alone ( OR , 1.93 ; 95 % CI , 1.42 - 2.61 ) , or in studies that included patients with a history of GI bleeding or of longer duration .

[{'class': 'NEG', 'spans': ['clopidogrel', 'ASA'], 'is_context_needed': False}]

Raloxifene , an anti-osteoporotic drug , is recently approved for prevention of breast cancer in postmenopausal women and thus the drug may be employed to combat the bony adverse effects of letrozole , another anticancer drug .

[{'class': 'POS', 'spans': ['Raloxifene', 'letrozole'], 'is_context_needed': True}]

In a previous trial , we found that adding the antiandrogen flutamide to leuprolide acetate ( a synthetic gonadotropin-releasing hormone that results in medical ablation of testicular function ) significantly improved survival as compared with that achieved with placebo plus leuprolide acetate .

[{'class': 'POS', 'spans': ['flutamide', 'leuprolide acetate'], 'is_context_needed': False}]

Contraceptives containing desogestrel or levonorgestrel have different effects on serum lipoproteins and post-heparin plasma lipase activities .

[{'class': 'COMB', 'spans': ['desogestrel', 'levonorgestrel'], 'is_context_needed': True}]

Concentrations of guaifenesin , diphenhydramine , and chlorpheniramine detected in the heart blood were 27.4 , 8.8 , and 0.2 mg/L , respectively .

[{'class': 'NEG', 'spans': ['guaifenesin', 'diphenhydramine', 'chlorpheniramine'], 'is_context_needed': True}]

The standard chemotherapy for localized ESFT now comprises vincristine , actinomycin D , cyclophosphamide and doxorubicin ( VACD ) in Europe or vincristine , doxorubicin , cyclophosphamide , ifosfamide and etoposide ( VDC-IE ) in North America .

[{'class': 'COMB', 'spans': ['vincristine', 'actinomycin D', 'cyclophosphamide', 'doxorubicin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [4, 5, 6, 7, 8], 'is_context_needed': True}]

Ceftriaxone plus gentamicin or ceftriaxone alone for streptococcal endocarditis in Japanese patients as alternative first-line therapies .

[{'class': 'NEG', 'spans': ['Ceftriaxone', 'gentamicin'], 'is_context_needed': True}]

Combined therapy : what does acamprosate and naltrexone combination tell us ?

[{'class': 'POS', 'spans': ['acamprosate', 'naltrexone'], 'is_context_needed': True}]

Reflecting the role of STAT3 in inducing localized immune suppression , using both atovaquone and pyrimethamine resulted in the modulation of immunoregulatory genes predicted to enhance an immune response , including upregulation of ICOSLG ( Inducible T-Cell Costimulator Ligand or B7H2 ) .

[{'class': 'POS', 'spans': ['atovaquone', 'pyrimethamine'], 'is_context_needed': False}]

TVR can be used in combination with tenofovir , emtricitabine and raltegravir for patients with hemophilia .

[{'class': 'POS', 'spans': ['tenofovir', 'emtricitabine', 'raltegravir', 'TVR'], 'is_context_needed': False}]

Topical therapy with azithromycin and oral therapy with doxycycline relieved signs and symptoms and restored the lipid properties of the meibomian gland secretion toward normal .

[{'class': 'POS', 'spans': ['azithromycin', 'doxycycline'], 'is_context_needed': False}]

Drug combinations , especially rapamycin + doxycycline may have promising anti-tumour effect in gliomas .

[{'class': 'POS', 'spans': ['rapamycin', 'doxycycline'], 'is_context_needed': False}]

Treatment with PUVA ( psoralen-ultraviolet-A ) combined with 40 - -80 mg prednisolone and then with chemotherapy [ COPP regimen ( cyclophosphamide , vincristine , procarbacine , prednisone ) , high-dosage methotrexate followed by citrovorum factor rescue ] was not successful .

[{'class': 'NEG', 'spans': ['prednisolone', 'cyclophosphamide', 'vincristine', 'prednisone', 'methotrexate', 'psoralen-ultraviolet-A', 'procarbacine', 'citrovorum'], 'is_context_needed': False}]

We evaluated a sequential treatment with Vinorelbine followed by Gemcitabine to determine its effect on survival and the toxicity in this patient population .

[{'class': 'POS', 'spans': ['Vinorelbine', 'Gemcitabine'], 'is_context_needed': True}]

Apoptosis in Hep2 cells treated with etoposide and colchicine .

[{'class': 'NEG', 'spans': ['etoposide', 'colchicine'], 'is_context_needed': True}]

The objective of this phase II study was to evaluate the efficacy and toxicity of carboplatin and weekly paclitaxel combination chemotherapy in previously untreated , advanced non-small cell lung cancer ( NSCLC ) .

[{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel'], 'is_context_needed': True}]

Therapy consisted of seven cycles of VCAP ( vincristine , cyclophosphamide , doxorubicin and prednisone ) , AMP ( doxorubicin , ranimustine and prednisone ) and VECP ( vindesine , etoposide , carboplatin and prednisone ) .

[{'class': 'POS', 'spans': ['vincristine', 'cyclophosphamide', 'doxorubicin', 'prednisone', 'doxorubicin', 'ranimustine', 'prednisone', 'etoposide', 'carboplatin', 'prednisone', 'vindesine'], 'is_context_needed': True}]

In HER2-amplified cells , the combination of trastuzumab and lapatinib was evaluated using the median effects principal .

[{'class': 'POS', 'spans': ['trastuzumab', 'lapatinib'], 'is_context_needed': True}]

Sorafenib monotherapy and combinations with taxanes , bevacizumab and ixabepilone showed inadequate efficacy , while efficacy results from combinations with gemcitabine and/or capecitabine and possibly tamoxifen were more promising .

[{'class': 'POS', 'spans': ['Sorafenib', 'gemcitabine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 4], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 5], 'is_context_needed': False}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]

This article reviews the pertinent studies regarding paclitaxel combined with cisplatin or carboplatin , discusses the remaining controversies surrounding how best to combine these agents , and provides opinions regarding the discordant outcomes noted in studies of the paclitaxel-platinum doublet .

[{'class': 'COMB', 'spans': ['paclitaxel', 'cisplatin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]

Hyperthermia could increase the sensitivity of SKOV3 to cis-platinum , carboplatin and oxaliplatin ( P < 0.05 ) .

[{'class': 'POS', 'spans': ['cis-platinum', 'Hyperthermia'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': False}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}]

A prospective phase 2 trial of short-course ( SC ) radiation therapy ( RT ) with 25 Gy over 5 fractions , followed by 4 cycles of 5-fluorouracil , oxaliplatin , and leucovorin ( mFOLFOX6 ) before surgery was recently completed at our institution .

[{'class': 'POS', 'spans': ['5-fluorouracil', 'oxaliplatin', 'leucovorin'], 'is_context_needed': True}]

[ A case of advanced gastric cancer successfully treated with trastuzumab , capecitabine , and Cisplatin therapy followed by curative resection ] .

[{'class': 'POS', 'spans': ['trastuzumab', 'capecitabine', 'Cisplatin'], 'is_context_needed': True}]

Sulpiride plus hydroxyzine decrease tinnitus perception .

[{'class': 'POS', 'spans': ['Sulpiride', 'hydroxyzine'], 'is_context_needed': False}]

We gave 2 , 3 , 5 and 5 mg/day/body of recombinant tissue plasminogen activator ( tPA ) followed by heparin and prostaglandin E1 ( PGE1 ) effectively and without significant side effect on days 9 , 10 , 13 and 14 , respectively .

[{'class': 'POS', 'spans': ['tissue plasminogen activator', 'heparin', 'prostaglandin E1'], 'is_context_needed': False}]

Roxithromycin and clarithromycin , 14-membered ring macrolides , potentiate the antitumor activity of cytotoxic agents against mouse B16 melanoma cells .

[{'class': 'POS', 'spans': ['Roxithromycin', 'clarithromycin'], 'is_context_needed': False}]

The EVA regimen ( etoposide , vinblastine , doxorubicin ) is an attempt to substitute a known active agent , etoposide , for bleomycin and dacarbazine .

[{'class': 'POS', 'spans': ['etoposide', 'vinblastine', 'doxorubicin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 2, 4, 5], 'is_context_needed': True}]

Carvedilol and imatinib mesylate alone reduced cell number , BrDU-LI , cAMP levels and spheroid volume .

[{'class': 'POS', 'spans': ['Carvedilol', 'imatinib'], 'is_context_needed': False}]

The recommended phase II dose ( RP2D ) was cytarabine 10 mg bid days 1 - 10 and sorafenib 600 mg/day days 2 - 28 .

[{'class': 'POS', 'spans': ['cytarabine', 'sorafenib'], 'is_context_needed': True}]

We performed a single-arm phase II trial of panitumumab in patients with KRAS wild-type metastatic colorectal cancer that had progressed on prior cetuximab .

[{'class': 'NEG', 'spans': ['panitumumab', 'cetuximab'], 'is_context_needed': True}]

Two Phase 1 studies assessed effects of ABT-450 ( 150 mg coadministered with ritonavir 100 mg once daily ) , ombitasvir ( 25 mg once daily ) , and dasabuvir ( 400 mg twice daily ) on the pharmacokinetics , safety , and tolerability of a single dose of cyclosporine ( 30 mg ) or tacrolimus ( 2 mg ) in healthy volunteers ( N = 12 per study ) .

[{'class': 'POS', 'spans': ['ABT-450', 'ritonavir', 'ombitasvir', 'dasabuvir', 'cyclosporine'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1, 2, 3, 5], 'is_context_needed': True}]

Antiplatelet therapy with dipyridamole , 100 mg q.i.d . , starting 2 days before surgery , followed by aspirin , 325 mg t.i.d . plus dipyridamole , 75 mg t.i.d . , 7 hours after surgery was assessed in the prevention of saphenous vein bypass graft occlusion .

[{'class': 'POS', 'spans': ['dipyridamole', 'aspirin', 'dipyridamole'], 'is_context_needed': True}]

Toxicity patterns following stepwise combinations of cyclophosphamide , methotrexate and fluorouracil .

[{'class': 'POS', 'spans': ['cyclophosphamide', 'methotrexate', 'fluorouracil'], 'is_context_needed': True}]

All patients were treated with the combination of lapatinib ( 1250 mg/day , continuously ) and capecitabine ( 2000 mg/m(2 ) on days 1 through 14 of a 21-day cycle ) .

[{'class': 'POS', 'spans': ['lapatinib', 'capecitabine'], 'is_context_needed': True}]

Effect of curcumin , a natural phytochemical in restoring doxorubicin sensitivity by targeting Aurora A was assessed furthermore .

[{'class': 'POS', 'spans': ['curcumin', 'doxorubicin'], 'is_context_needed': True}]

Our goals were to : establish the maximum-tolerated dose of olaparib tablets combined with metronomic carboplatin and paclitaxel in patients with relapsed high-grade serous ovarian cancer ; evaluate dose-limiting toxicities ; and evaluate efficacy at the maximum tolerated dose .

[{'class': 'POS', 'spans': ['olaparib', 'carboplatin', 'paclitaxel'], 'is_context_needed': True}]

All patients in this study were treated with decitabine of 15 mg/m2 for 5 days and G-CSF for priming , in combination with cytarabine of 10-mg/m2 q12h for 7 days and aclarubicin of 10 mg/day for 4 days ( D-CAG ) .

[{'class': 'POS', 'spans': ['decitabine', 'cytarabine', 'aclarubicin'], 'is_context_needed': True}]

Pertuzumab is the most recent agent approved by the US Food and Drug Administration in combination with trastuzumab and docetaxel for the treatment of patients with HER2(+ ) metastatic breast cancer who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease .

[{'class': 'POS', 'spans': ['Pertuzumab', 'trastuzumab', 'docetaxel'], 'is_context_needed': False}]

Safety and efficacy of sorafenib followed by regorafenib or lenvatinib in patients with hepatocellular carcinoma .

[{'class': 'COMB', 'spans': ['sorafenib', 'regorafenib'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]

The combination of boceprevir or telaprevir with peginterferon-alfa and ribavirin for the treatment of patients infected with HCV genotype 1 has led to significantly increased rates of sustained virological response ( SVR ) in phase III trials .

[{'class': 'POS', 'spans': ['boceprevir', 'peginterferon-alfa', 'ribavirin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 2, 3], 'is_context_needed': True}]

In contrast , the combination of plumbagin with AR antagonists , such as bicalutamide and enzalutamide , showed no improvement over AR antagonists alone .

[{'class': 'COMB', 'spans': ['bicalutamide', 'plumbagin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 2], 'is_context_needed': True}]

The B-cell lymphoma 2 ( BCL-2 ) inhibitor venetoclax has an emerging role in acute myeloid leukemia ( AML ) , with promising response rates in combination with hypomethylating agents or low-dose cytarabine in older patients .

[{'class': 'POS', 'spans': ['venetoclax', 'cytarabine'], 'is_context_needed': False}]

Combination chemotherapy with vincristine , bleomycin , and methotrexate for advanced head and neck cancers .

[{'class': 'NEG', 'spans': ['vincristine', 'bleomycin', 'methotrexate'], 'is_context_needed': True}]

Combination therapy with labetalol ( 400 mg/day ) and prazosin ( 6 mg/day ) was unsatisfactory , and the addition of long-acting nifedipine ( 40 mg/day ) produced a marked decrease in blood pressure .

[{'class': 'NEG', 'spans': ['labetalol', 'prazosin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 1, 2], 'is_context_needed': False}]

It was identified as C. lunata ( Wakker ) Boedijn var . aeria ( Batista , Lima and Vasconcelos ) Ellis ( IMI 253204 ) and its growth was better at 28 degrees C than at 37 degrees C. In vitro , the fungus was most sensitive to amphotericin B followed by miconazole nitrate , clotrimazole and triphenyltin isoselenocyanate 4-picoline which had the same activity .

[{'class': 'POS', 'spans': ['amphotericin', 'miconazole', 'clotrimazole', 'triphenyltin isoselenocyanate 4-picoline'], 'is_context_needed': False}]

Conclusions Everolimus plus mFOLFOX-6 + bevacizumab is tolerable and demonstrated preliminary efficacy for first-line mCRC .

[{'class': 'POS', 'spans': ['Everolimus', 'bevacizumab', 'mFOLFOX-6'], 'is_context_needed': False}]

We conducted a prospective phase II study to determine the response rate , toxicity , and survival rate of concurrent weekly paclitaxel , carboplatin , and hyperfractionated radiation therapy ( paclitaxel/carboplatin/HFX RT ) followed by 2 cycles of paclitaxel and carboplatin for locally advanced unresectable non-small cell lung cancer ( NSCLC ) .

[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]

A phase Ib study of pertuzumab , a recombinant humanised antibody to HER2 , and docetaxel in patients with advanced solid tumours .

[{'class': 'POS', 'spans': ['pertuzumab', 'docetaxel'], 'is_context_needed': True}]

These data suggest that vorinostat and doxorubicin may induce procoagulant activity in vessels through apoptosis of tumor cells and through phosphatidylserine exposure and/or tissue factor expression on vascular endothelial cells .

[{'class': 'NEG', 'spans': ['vorinostat', 'doxorubicin'], 'is_context_needed': True}]

Based on encouraging results of previous combination regimens , we used a combination of VM26 , ifosfamide , methyl GAG , mitoxantrone ( or adriamycin ) , high-dose ( HD ) methotrexate and HD Ara C to treat 18 patients with relapsed or refractory NHL .

[{'class': 'POS', 'spans': ['VM26', 'ifosfamide', 'methyl GAG ,', 'mitoxantrone', 'methotrexate', 'Ara C'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1, 2, 4, 5, 6], 'is_context_needed': True}]

We treated this patient with six cycles of CHOEP ( Cyclophosphamide , Doxorubicin , Vincristine , Etoposide , and Prednisone ) chemotherapy .

[{'class': 'POS', 'spans': ['Cyclophosphamide', 'Doxorubicin', 'Vincristine', 'Etoposide', 'Prednisone'], 'is_context_needed': True}]

One study evaluated gemcitabine with gemcitabine and pertuzumab .

[{'class': 'NEG', 'spans': ['gemcitabine', 'pertuzumab'], 'is_context_needed': True}]

We conclude that the combination of thiotepa , 5FU , and leucovorin had significant myelotoxicity and do not recommend its routine use in the treatment of metastatic breast cancer .

[{'class': 'NEG', 'spans': ['thiotepa', '5FU', 'leucovorin'], 'is_context_needed': False}]

Forty-two patients with stage III to IV resectable HNSCC and nasopharyngeal tumors received induction chemotherapy with two courses of cisplatin ( 20 mg/m2/d continuous infusion [ CI ] ) , fluorouracil ( 800 mg/m2/d CI ) , and leucovorin ( 500 mg/m2/d CI ; PFL ) for 4 days followed by concurrent therapy with cisplatin ( 100 mg/m2/d on days 1 and 22 ) and approximately 70 Gy of external-beam radiotherapy .

[{'class': 'POS', 'spans': ['cisplatin', 'fluorouracil', 'leucovorin'], 'is_context_needed': True}]

Will a combination of l-leucine with low-dose metformin and sildenafil produce a novel synergistic interaction that reduces body weight ?

[{'class': 'POS', 'spans': ['l-leucine', 'metformin', 'sildenafil'], 'is_context_needed': True}]

Combinatory activity of linezolid and levofloxacin with antituberculosis drugs in Mycobacterium tuberculosis .

[{'class': 'POS', 'spans': ['linezolid', 'levofloxacin'], 'is_context_needed': True}]

Canadian clinical guidelines recommend the use of the combination of tamsulosin and dutasteride for men with moderate/severe symptoms associated with BPH and enlarged prostate volume .

[{'class': 'POS', 'spans': ['tamsulosin', 'dutasteride'], 'is_context_needed': False}]

The present study was designed to test the effects of chronic combined treatment with low doses of an angiotensin converting enzyme inhibitor ( perindopril ) and of the diuretic indapamide in spontaneously hypertensive rats ( SHR ) .

[{'class': 'POS', 'spans': ['perindopril', 'indapamide'], 'is_context_needed': True}]

A phase 3 trial of azacitidine versus a semi-intensive fludarabine and cytarabine schedule in older patients with untreated acute myeloid leukemia .

[{'class': 'NEG', 'spans': ['fludarabine', 'cytarabine'], 'is_context_needed': True}]

Five other treatments closely followed ( dabrafenib [ HR PFS : 0.30 ] , nivolumab plus ipilimumab [ HR PFS : 0.34 ] , vemurafenib [ HR PFS : 0.38 ] , nivolumab [ HR PFS : 0.42 ] and pembrolizumab [ HR PFS : 0.46 ] ) .

[{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': True}]

Patients with newly diagnosed , locally advanced stage III or IV SCCHN received 4 weekly doses of carboplatin ( area under the curve , 1.5 ) and paclitaxel ( 45 mg/m(2 ) ) concurrently with concomitant boost radiation consisting of 72 grays in 42 fractions over 6 weeks ( every day for 18 days , twice a day for 12 days ) ( grading determined according to the TNM staging system ) .

[{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel'], 'is_context_needed': True}]

Phase 1b trial of docetaxel , prednisone , and pazopanib in men with metastatic castration-resistant prostate cancer .

[{'class': 'POS', 'spans': ['docetaxel', 'prednisone', 'pazopanib'], 'is_context_needed': True}]

Growth inhibition of cloned promastigotes showed that the films have enough releasing capacity and in vivo system , the films containing paromomycin and gentamicin was able to reduce the lesion size and induced complete cure in 80 % of the mice but relapse was seen in 60 % of the cured mice and overall 50 % cure rate was seen during 20 weeks period of the study .

[{'class': 'POS', 'spans': ['paromomycin', 'gentamicin'], 'is_context_needed': False}]

Management and outcome : The patient was initially treated with bortezomib and dexamethasone for the myeloma .

[{'class': 'COMB', 'spans': ['bortezomib', 'dexamethasone'], 'is_context_needed': True}]

We retrospectively evaluated 52 metastatic renal cell carcinoma patients who were treated with nivolumab plus ipilimumab between August 2015 and January 2020 .

[{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': True}]

Microdialysis-based pharmacokinetic studies demonstrated that administration of the P-gp inhibitor cyclosporin A resulted in increased brain levels of escitalopram without altering plasma escitalopram levels in the rat , thereby showing that P-gp restricts escitalopram transport across the blood-brain barrier ( BBB ) in vivo .

[{'class': 'POS', 'spans': ['cyclosporin', 'escitalopram'], 'is_context_needed': False}]

The combination of mezlocillin and an aminoglycoside produced synergy more often than did carbenicillin plus an aminoglycoside .

[{'class': 'POS', 'spans': ['mezlocillin', 'aminoglycoside'], 'is_context_needed': False}, {'class': 'COMB', 'spans': [1, 3], 'is_context_needed': True}]

Eligible patients ( n = 17 ) were divided into 2 groups receiving a combined chemotherapy of intravenous cisplatinum ( 70 mg/m2 ) and cyclophosphamide ( 700 mg/m2 ) with or without the addition of Lenograstim .

[{'class': 'POS', 'spans': ['cisplatinum', 'cyclophosphamide', 'Lenograstim'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}]

Ifosfamide at 12 g/m2 was administered by intravenous continuous infusion over 3 days , and doxorubicin 60 mg/m2 was administered as an intravenous bolus injection on day 1 .

[{'class': 'POS', 'spans': ['Ifosfamide', 'doxorubicin'], 'is_context_needed': True}]

A Randomized , Double-blind , Placebo-controlled Trial of Celecoxib Augmentation of Sertraline in Treatment of Drug-naive Depressed Women : A Pilot Study .

[{'class': 'POS', 'spans': ['Celecoxib', 'Sertraline'], 'is_context_needed': True}]

In seven patients with type B insulin resistance , standardized treatment with rituximab , cyclophosphamide , and pulse steroids results in remission of the disease .

[{'class': 'POS', 'spans': ['rituximab', 'cyclophosphamide', 'steroids'], 'is_context_needed': False}]

The purpose of this study was to determine the fertility rates following treatment by means of the BEACOPP regimen ( regular and escalated ) ( bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , prednisone ) as compared to the ABVD regimen ( doxorubicin , vinblastine , dacarbazine , bleomycin ) in Hodgkin lymphoma patients under the age of 40 at the time of treatment .

[{'class': 'POS', 'spans': ['bleomycin', 'etoposide', 'doxorubicin', 'cyclophosphamide', 'vincristine', 'procarbazine', 'prednisone'], 'is_context_needed': True}, {'class': 'POS', 'spans': [8, 9, 10, 7], 'is_context_needed': True}]

The positive inotropism of DPDPE was abrogated in animals pretreated with propranolol , CGRP(8 - 37 ) , or combined propranolol+CGRP(8 - 37 ) .

[{'class': 'COMB', 'spans': ['DPDPE', 'propranolol'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1, 2], 'is_context_needed': True}]

A case of Scedosporium apiospermum infection after BMT , treated initially with amphotericin B ( total dose of 2.5 g ) and then with itraconazole ( for 25 days ) , is reported here .

[{'class': 'NEG', 'spans': ['amphotericin', 'itraconazole'], 'is_context_needed': True}]

Thymidine Phosphorylase/β-tubulin III expressions predict the response in Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel .

[{'class': 'COMB', 'spans': ['capecitabine', 'paclitaxel'], 'is_context_needed': True}]

Modeling of the pharmacokinetic/pharmacodynamic interaction between irbesartan and hydrochlorothiazide in normotensive subjects .

[{'class': 'COMB', 'spans': ['irbesartan', 'hydrochlorothiazide'], 'is_context_needed': True}]

In Group IV , the augmentation of Pdi by olprinone was abolished in the fatigued diaphragm with an infusion of nicardipine .

[{'class': 'NEG', 'spans': ['olprinone', 'nicardipine'], 'is_context_needed': False}]

In a 71 years-old patient , a severe therapy-resistant depressive episode without psychotic symptoms was successfully treated by a combination of paroxetine and risperidone .

[{'class': 'POS', 'spans': ['paroxetine', 'risperidone'], 'is_context_needed': False}]

While there is no standard of care for PBL , current recommendations include dose-adjusted EPOCH ( etoposide , vincristine , doxorubicin , cyclophosphamide , and prednisone ) , with or without bortezomib .

[{'class': 'POS', 'spans': ['etoposide', 'vincristine', 'doxorubicin', 'cyclophosphamide', 'prednisone'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 1, 2, 3, 4, 5], 'is_context_needed': False}]

Our report of a patient with severe tardive dyskinesia ( TD ) who has been exposed to both typical antipsychotic and clozapine , olanzapine and quetiapine during a 124-week follow-up period supports the possible beneficial effect of atypical antipsychotics on pre-existing symptoms of TD .

[{'class': 'POS', 'spans': ['clozapine', 'olanzapine', 'quetiapine'], 'is_context_needed': False}]

Paclitaxel plus bevacizumab in patients with chemosensitive relapsed small cell lung cancer : a safety , feasibility , and efficacy study from the Hoosier Oncology Group .

[{'class': 'NEG', 'spans': ['Paclitaxel', 'bevacizumab'], 'is_context_needed': True}]

Significantly , genes regulated by both formoterol and budesonide were overrepresented in the genome ; moreover , budesonide-plus-formoterol induced and repressed 609 and 577 mRNAs , respectively , of which ~1/3 failed the cut-off criterion for either treatment alone .

[{'class': 'POS', 'spans': ['formoterol', 'budesonide'], 'is_context_needed': True}]

This study aimed to investigate the therapeutic responses of lung cancer mice models with adenocarcinoma HCC827 ( gefitinib sensitive ) and HCC827R ( gefitinib resistant ) to the epidermal growth factor receptor-tyrosine kinase inhibitor erlotinib alone and in combination with the anti-angiogenesis agent bevacizumab using dynamic contrast enhanced ( DCE ) and diffusion-weighted MRI .

[{'class': 'POS', 'spans': ['gefitinib', 'erlotinib'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2, 3], 'is_context_needed': True}]

, olmesartan medoxomil + amlodipine + HCTZ was more effective in reducing BP and achieving BP goals than each of the dual therapies , irrespective of hypertension severity , age , sex , race or diabetes mellitus status .

[{'class': 'POS', 'spans': ['olmesartan medoxomil', 'amlodipine', 'HCTZ'], 'is_context_needed': False}]

Multiple-dose pharmacokinetics of telmisartan and of hydrochlorothiazide following concurrent administration in healthy subjects .

[{'class': 'POS', 'spans': ['telmisartan', 'hydrochlorothiazide'], 'is_context_needed': True}]

The objective of the current study was to determine whether adding the mammalian target of rapamycin inhibitor temsirolimus to sorafenib could improve on these results .

[{'class': 'POS', 'spans': ['temsirolimus', 'sorafenib'], 'is_context_needed': True}]

The authors report the case of a 4-year-old boy with a diagnosis of stage IV neuroblastoma ( NB ) , who had been treated with 6 cycles of cyclophosphamide , doxorubicin , cisplatin , and etoposide for 12 months .

[{'class': 'COMB', 'spans': ['cyclophosphamide', 'doxorubicin', 'cisplatin', 'etoposide'], 'is_context_needed': True}]

Due to dose-limiting toxicity ( DLT ) in both patients ( elevated transaminases and thrombocytopenia ) , an additional three patients were treated on dose level -1 with trabectedin 0.7 mg/m2 plus gemcitabine 700 mg/m2 .

[{'class': 'NEG', 'spans': ['trabectedin', 'gemcitabine'], 'is_context_needed': True}]

He accepted surgical resection with followed multi-agent chemotherapy , containing vincristine , doxorubicin , ifosfamide and etoposide .

[{'class': 'POS', 'spans': ['vincristine', 'doxorubicin', 'ifosfamide', 'etoposide'], 'is_context_needed': True}]

The gemcitabine and mitoxantrone regimen was feasible to administer even in heavily pre-treated patients .

[{'class': 'POS', 'spans': ['gemcitabine', 'mitoxantrone'], 'is_context_needed': False}]

The aim of this study was to evaluate four phytocompounds ( cinnamaldehyde , citral , eugenol and geraniol ) for their in vitro inhibitory activity against pre-formed biofilms of Candida albicans alone or in combination with fluconazole and amphotericin B. These compounds were also tested at subinhibitory concentrations for their ability to inhibit biofilm formation .

[{'class': 'POS', 'spans': ['cinnamaldehyde', 'fluconazole'], 'is_context_needed': True}]

Neoadjuvant trastuzumab , pertuzumab , and chemotherapy versus trastuzumab emtansine plus pertuzumab in patients with HER2-positive breast cancer ( KRISTINE ): a randomised , open-label , multicentre , phase 3 trial .

[{'class': 'POS', 'spans': ['trastuzumab', 'pertuzumab', 'trastuzumab emtansine', 'pertuzumab'], 'is_context_needed': True}]