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10,001,000 | Thirteen patients undergoing hemodialysis who were carriers of hepatitis B virus (HBV) were screened for inappropriate reactions to HBV transmission risks and for emotional reactions to their renal and viral diseases. Four patients underreacted to HBV transmission risks through denial or misunderstanding. The nine remaining patients reported that their HBV, as compared with their renal disease, resulted in substantially greater restrictions in interpersonal relations and significantly greater feelings of not being accepted by others. In contrast, the nine patients reported that their renal disease, as compared with their HBV, resulted in substantially greater restrictions in leisure and work activities. Thirteen control patients undergoing hemodialysis but not having HBV did not differ from the patients with HBV in psychosocial reactions to renal disease. As shown in a one-month follow-up, counseling was effective in enhancing awareness of HBV transmission risks and in improving emotional adjustments to the renal and viral diseases. | [
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10,001,001 | Granulomatosis vasculitis in the syndrome of diffuse fasciitis with eosinophilia. | [
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10,001,002 | Two patients had an illness with clinical features of the syndrome of diffuse fasciitis with eosinophilia. The histologic findings in both patients showed granuloma formation in association with prominent vasculitis, in addition to other previously reported histologic features. The findings in these two cases raise the possibility that this syndrome should be classified with the vasculitides rather than as a variant of scleroderma. | [
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10,001,003 | Pneumonia and influenza deaths during epidemics: implications for prevention. | [
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10,001,004 | Pneumonia and influenza (P&I) deaths among adults during epidemics of influenza A (H3N2) virus are reviewed and risks of such deaths according to age and presence of chronic disease are estimated from medical records of a large group practice. Thirty-eight deaths occurred among 310 persons hospitalized with P&I. Flu-like symptoms occurred in 30 patients (79%), 26 patients (68%) were older than 65 years, 36 patients (95%) had chronic disease, and approximately half were medically stable before the terminal episode. These values were similar to those of P&I deaths during nonepidemic periods. Pneumonia and influenza death rates ranged from fewer than ten to more than 600 per 100,000 among healthy vs chronically ill adults. Highest rates (870 per 100,000) occurred in persons with both cardiovascular and pulmonary disease. Application of these findings to influenza vaccination strategies in clinical practice is discussed. | [
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10,001,005 | Chemotherapy for lymphoma in a patient with common variable immunodeficiency: case report, literature review, and recommendations for chemotherapy in immunodeficient patients. | [
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] |
10,001,006 | A man with long-standing common variable hypogammaglobulinemia was treated with chemotherapy and local radiation for diffuse mixed lymphoma. He continues in complete remission 42 months after the completion of therapy. Vigorous therapy for lymphoma can be used in the face of preexistent immunodeficiency. Complete staging and appropriate combination chemotherapy or radiation therapy should be carried out for lymphomas that occur in certain immunodeficient patients. | [
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10,001,007 | Late results of obliterative cholesteatoma surgery. | [
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] |
10,001,008 | Radical obliterative cholesteatoma surgery was performed on 463 ears. Post-operative cholesteatomas were found in 22 of 463 of the ears during the follow-up periods that ranged from five to 15 years. Eight of them were of the residual type, and 14 were of the recidive type. A substantial portion of the postoperative cholesteatomas (11 cases) was discovered as late as the sixth to the tenth postoperative years. Four of the postoperative cholesteatomas extended to the antrum or the operation cavity from the tympanic cavity or meatus, but none of them originated in the cavity area. The surgical method that was used was safe. Annual follow-up examinations for at least ten years are recommended after the obliterative radical operation for ears with cholesteatomas. | [
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10,001,009 | Mycobacterium fortuitum as a cause of mastoiditis and wound infection. | [
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10,001,010 | Mycobacterium fortuitum is uncommonly pathogenic for man. When implicated, this organism usually infects soft-tissue structures. Therapy necessitates surgical excision and prolonged antimicrobial therapy. A patient had a mastoiditis and wound infection due to this organism. Her successful treatment included radical debridement and prolonged therapy with several antimicrobials. The necessity for including mycobacteria in the differential diagnosis of ear, nose, and throat diseases is emphasized by our experience. The complexities of management of these infections are reviewed. | [
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10,001,011 | Patterns in the performance-intensity functions for phonetically balanced word lists and synthetic sentences in aged listeners. | [
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10,001,012 | The performance intensity-phonetically balanced (PI-PB) and performance intensity-synthetic sentence identification (PI-SSI) functions were determined for 62 elderly patients (100 ears) with presbyacusis. A comparison of these functions was performed to determine whether patients older than 60 years exhibited peripheral or central PI-PB/PI-SSI patterning. Fifty-eight ears of the 100 ears examined showed central patterning. Furthermore, two diagnostically important central patterns were identified. The implications of the current data as well as the clinical application of PI-PB/PI-SSI testing for the evaluation of peripheral and central auditory effects in aged listeners are described. | [
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10,001,013 | The radiobiological basis for tissue reactions in the oral cavity following therapeutic x-irradiation. A review. | [
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10,001,014 | The radiobiological basis for the response of tissues in the oral cavity following therapeutic doses of ionizing radiation has been reviewed. Clinical manifestations of radiation response occur when the functional compartment of the tissue, the parenchymal cells, is depleted to some minimal value. The time course and severity of the response depend on the sensitivity of cellular compartments, the vegetative intermitotic compartment being the most sensitive and the fixed postmitotic cells being the least sensitive. Early responses are therefore seen in rapid cell renewal systems while the chronic effects are closely correlated with damage to the terminal vascular bed, a multipotential connective tissue compartment. Osteonecrosis of bone following irradiation involves a series of events, including a decreased salivary gland function, devitalization of bone, and infection. Carcinogenesis in oral cavity tissues is a very rare late sequela of therapeutic radiation. | [
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10,001,015 | Repair of subglottic stenosis with a free perichondrial graft. | [
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] |
10,001,016 | Previous work with dogs has shown that a free perichondrial graft will predictably produce new cartilage when placed in the trachea. In the absence of a wound infection, the production of cartilage was predictable although the amount of cartilage varied. The present study sought to determine if enough cartilage could be produced to correct an acquired subglottic stenosis. In all dogs in whom a wound infection did not occur, enough cartilage was produced to support and maintain the subglottic lumen. | [
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10,001,017 | Chronic osteomyelitis following mandibular fractures and its treatment. | [
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10,001,018 | In a review of 350 patients with mandibular fractures between 1976 and 1978, eight cases of chronic mandibular osteomyelitis were found. Treatment in all cases consisted of intravenous antibiotics and debridement. In addition, in some cases a suction-irrigation system was used after debridement. From this study, the following can be stated: (1) Osteomyelitis following mandibular fractures is uncommon. (2) Once chronic osteomyelitis has developed, aggressive antibiotic and surgical treatment is needed. (3) The use of the suction-irrigation system after debridement is an effective adjunctive aid in treating osteomyelitis. Cosmesis is superior to that obtained with older techniques because wounds are closed primarily. | [
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] |
10,001,019 | Rhinorrhea and Pseudomonas meningitis associated with a rhinopharyngeal tumor. | [
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10,001,020 | A patient with a neoplastic tumor of the rhinopharynx had Pseudomonas aeruginosa meningitis, the origin of which could be traced back to an occult CSF fistula caused by the tumor. From a review of the literature, it seems that this is a rare clinical occurrence. | [
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10,001,021 | Acute calcific retropharyngeal tendonitis. | [
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10,001,022 | Primary syphilis of the tonsil. | [
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10,001,023 | A 42-year-old patient with an ulcerative left tonsil that was not particularly painful was examined. The routine blood test for syphilis was reactive. The patient was found to have a chancre of the left tonsil. Painless ulcers of the left tonsil in a sexually active individual should be considered as possibly syphilitic. | [
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10,001,024 | A case of vocal cord nodules masking essential (voice) tremor. | [
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10,001,025 | Essential tremor is a progressive, potentially debilitating disorder that may be manifested in the voice only. In the case we report, the signs occurred concurrently with the voice characteristics of vocal cord nodules but were subtle. The mildness of the voice tremor precluded treatment at this time, although the results of medical management for the disorder have not been impressive. It is probable that some patients with severe essential (voice) tremor have undergone recurrent laryngeal nerve resection for the disorder. | [
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10,001,026 | Management of amyloidosis of the larynx and trachea. | [
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10,001,027 | Amyloidosis involving the upper portion of the respiratory tract is an uncommon disorder that may occur as an isolated phenomenon or, more unusually, as part of a systemic amyloidosis. This case of a 66-year-old man with amyloidosis of the larynx and trachea illustrates some recently developed concepts and techniques in the diagnosis and management of this problem. | [
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10,001,028 | Lipoma of the nasopharynx. | [
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] |
10,001,029 | A 49-year-old woman had a histologically proved lipoma of the nasopharynx. Though the tumor almost filled the inferior portion of the nasopharynx, the patient has no other otolaryngologic findings except mild sensorineural hearing loss. To our knowledge, this is the first report of a nasopharyngeal lipoma in an adult. The lesion was histologically typical of lipomas occurring elsewhere in the body. | [
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10,001,030 | Pathologic quiz case 1: capillary hemangioma of the nose tip. | [
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] |
10,001,031 | Pathologic quiz case 2: chondroma with atypia. | [
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] |
10,001,032 | The sodium fluoride 'catch-22'. | [
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10,001,033 | Three patients with structurally abnormal X chromosomes, each with Xq13 breakpoints and a history of idiopathic acquired sideroblastic anemia. | [
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10,001,034 | Structural abnormalities of the X chromosome are rarely found in neoplastic disorders. We describe three patients with a history of idiopathic acquired sideroblastic anemia (IASA); each one had an abnormal clone of cells in the bone marrow, characterized by a structurally abnormal X chromosome. In two of these patients, the predominant karyotype was 47,X,2idic(X)(q13); in the other patient, it was 46,X,t(X;11)(q13;p15). Inasmuch as all three of these cases involved chromosome band Xq13, as did two previously published cases, we suggest that band Xq13 may be more prone to structural rearrangement than other X chromosome bands in hematologic disorders. The common Xq13 chromosome breakpoint and clinical presentation (IASA) among these three patients and the occurrence of an X-linked type of sideroblastic anemia may suggest that an association exists between X chromosome abnormalities and IASA. Perhaps alteration of a gene or chromosome structure in or near band Xq13 predisposes to development of IASA. The fact that two of these patients had preleukemia and the third had overt acute leukemia may imply that patients with IASA and X chromosome abnormalities have a poor prognosis. Cases of IASA without associated X chromosome abnormalities are known; thus, if an association between IASA and an abnormal X chromosome does exist, most likely it involves only some patients with IASA. | [
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10,001,036 | Progenitors of blast cell colonies have been identified in acute leukemia. The peripheral blood of 18 of 25 patients with preleukemic states yielded low numbers of blast cell colonies, and the colony-forming cells were in an active proliferative state when assessed using short-term exposure to tritiated thymidine. The clinical significance of blast cell colonies is uncertain, but we suggest that further analysis of this cultural abnormality may lead to a better understanding of mechanisms and management in preleukemia. | [
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10,001,037 | Mode of action of the IgG inhibitor of erythropoiesis in transient erythroblastopenia of children. | [
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10,001,038 | Twelve cases of transient erythroblastopenia of childhood (TEC) have been studied to evaluate their marrow cell erythropoiesis in vitro and the effect on it of their serum or IgG. The number of colony-forming units-erythroid (CFU-E) and burst-forming units-erythroid (BFU-E) in the bone marrow of nine cases was extremely variable and did not allow any conclusion regarding the pathogenesis of this anemia. An IgG inhibitor of growth of erythroid colonies or bursts was detected in 8/12 cases. This IgG inhibitor had no effect on the growth of granulocyte-macrophage colonies. Further studies on its mode of action indicated that the IgG did not have antierythropoietin antibody properties and did not affect the mature erythroblasts, as shown by a lack of inhibition of their responses to erythropoietin and by the lack of a cytotoxic effect on 59Fe-labeled erythroblasts. In four cases, preincubation studies demonstrated a direct effect of the IgG on the CFU-E, which was complement-mediated in three cases and complement-independent in one case. In two other cases, the IgG suppressed the growth of normal BFU-E only without affecting the growth of CFU-E. The IgG inhibitor was no longer present after the erythroblastopenia had remitted. These studies demonstrate that in the majority of cases of TEC, an IgG suppressor of erythropoiesis in vitro is present. Its mode of action is heterogeneous regarding its requirement for complement. Its target cells are the earlier or later erythroid progenitors, BFU-E or CFU-E, but not the differentiated erythroblasts. | [
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10,001,039 | The effect of malonyldialdehyde on erythrocyte deformability. | [
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10,001,040 | The addition of malonyldialdehyde (5-20 micro M) to human erythrocytes results in a marked decrease in cellular deformability as measured with a counter-rotating, cone plate Rheoscope when low shear forces (2.5-25 dynes/sq cm) are applied. At high shear forces (125-500 dynes/sq cm), malonyldialdehyde at 5 micro M had no effect on deformability, although at concentrations of 10 and 20 micro M a small but statistically significant decrease was evident. These effects of this crosslinking agent are observed in the absence of alterations in cell volume and intracellular viscosity. The results obtained are in accord with the view that the polymerization of membrane constituents may contribute to the events that lead to the removal from the circulation of either aging cells or cells exposed to peroxidation-initiating agents. | [
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10,001,041 | Antibody-dependent cytolysis of the human leukemia cell line K-562 in the absence of effector cells or complement. | [
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] |
10,001,042 | K-562 human leukemia cells grown in the presence of specific goat anti-K-562 gamma globulin, F(ab)'2, Fab', or Fab showed a decrease in DNA and protein syntheses and a loss of cell viability within several hours. Eventually all cells died and lysed within 2-5 days. These events occurred in the absence of added effector cells or complement. The effect on the cell was not due to proteolytic or other external lytic activity generated at the cell surface, since 51Cr-labeled bystander cells or antibody-sensitized bystander cells (chicken erythrocytes or K-562 cells) were not lysed when added to cultures of K-562 cells incubated with immune globulin. The anti-K-562 gamma globulin was not observed to patch or cap on K-562 cells, but the ability of bound immunoglobulin to fix complement decreased markedly (50% in 60 min), so that no complement-mediated cytolysis could be observed at 2 hr. However, the immunoglobulin, at least portions of it, reacted with fluorescein--labeled rabbit anti-goat gamma globulin for about 16 hr. 125I-labeled immune globulin appeared to be internalized and released into the medium as small degradation products. 125I-labeled Fab did not appear to be internalized, since it was released intact and more rapidly from cells than the intact globulin. | [
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10,001,043 | A new case of deficiency of the R binder for cobalamin, with observations on minor cobalamin-binding proteins in serum and saliva. | [
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10,001,044 | A patient presented at the age of 77 yr with a low serum cobalamin level. Subsequent study showed that he had persistently very low R binder (TC I) cobalamin-binding capacity in serum (less than 5 ng/liter versus 213 +/- 171 ng/liter in normal controls), and that almost all of his endogenous serum cobalamin was carried by TC II instead of TC I. His saliva also demonstrated virtually undetectable R binder (binding capacity of 31-38 ng/liter versus 41,690 +/- 23,820 ng/liter for control subjects). Unlike previous cases of R binder deficiency, he seemed to maintain normal serum cobalamin levels while receiving monthly cyanocobalamin injections. This and his normal serum unsaturated binding capacity were due to elevated TC II levels. TC II carried 72%-98% of his endogenous cobalamin, the rest being attached to minor binders. As incidental findings, the patient had a serum component of molecular weight of approximately 70,000 that carried 7%-8% of his endogenous cobalamin and also had small quantities of TC II demonstrable in his saliva. Both these heretofore unappreciated minor peaks were identifiable because of the lack of R binder. The patient's clinical presentation supports the conclusion that R binder deficiency is a benign disorder. Whether his mild hypersegmentation of neutrophils and neuropathy were related to the R binder deficiency or, more likely, arose from coexisting folate deficiency and alcohol abuse, the overall picture contrasts dramatically with the severe clinical sequelae of TC II deficiency. | [
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10,001,045 | Use of a radioimmunoassay to quantify thrombospondin. | [
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10,001,046 | Results of radioimmunoassay procedures applied to samples containing thrombospondin indicated that reliable values are obtained either in saline or in plasma. Plasma levels in apparently normal individuals ranged from approximately 20 to 300 ng/ml. The mean for 20 individuals was 175 ng/ml. Plasma specimens stored either refrigerated at 4 degrees C or frozen at -80 degrees C showed significantly diminished thrombospondin levels over a period of 90 days. Serum levels of thrombospondin were found to range from 10,000 to 30,000 ng/ml. | [
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10,001,047 | Cold-induced contact surface activation of the prothrombin time in whole blood. | [
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10,001,048 | Studies of the prothrombin time (PT) have revealed that contact with borosilicate or commercial siliconized borosilicate markedly shortens the PT. This shortening is related to the activation of the contact phase of blood coagulation. This shortening of the PT occurs in both normal whole blood and plasma when stored in borosilicate or siliconized borosilicate tubes at 4 degree C and to a lesser degree at room temperature. Studies indicated the importance of several coagulation factors in decreasing the PT. The PT did not change in blood deficient in factor XII or in plasma deficient in Fletcher factor or high molecular weight kininogen, while blood deficient in CI esterase inhibitor (CI INH) had the most profound shortening. Shortening of the PT correlated directly with increased levels of factor VII. When purified CI INH was added to normal blood, it markedly reduced the activation of factor VII and the shortening of the PT in a dose-related manner. These studies indicate the pivotal roles of the contact phase of coagulation in initiating activation of the PT and of CI INH in inhibiting the activation of the coagulation factor(s) responsible for the cold-promoted activation of factor VII. | [
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10,001,049 | Cell markers in hairy cell leukemia studied in cells from 51 patients. | [
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] |
10,001,050 | To determine the maturation arrest of the neoplastic cells of hairy-cell leukemia (HCL) and the spectrum of the surface markers on these cells, a series of 51 patients with this disease was studied. The cells of all but two of the patients showed monoclonal surface Ig with respect to light chains. In about one-third of the cases, only gamma heavy chain determinants were present on the cells; the majority carried multiple heavy chain determinants as documented by the application of different fluorochromes. Two patients each showed two different clones of cells, both of the same light chain type. In one of these two patients, two paraproteins were present in the serum. Intracytoplasmic Ig was found in only 4 of 39 cases, in all instances being IgM. All cases studied concerned cells with FclgG receptors; however, the density of this receptor varied. FcIgM receptors also showed a spectrum of density, with some cases showing very few FcIgM-positive cells. Receptors C3 were not observed on the hairy cells. Serum immunoglobulin levels were normal or increased. Paraproteins were found in the sera of 4 of 38 patients. These data suggest that HCL is a neoplasm of B lymphocytes. The neoplastic cells are probably arrested at a more mature stage than the cells of chronic lymphocytic leukemia. The multiple isotypes on the cells indicate a block at the "switch" phase from the small micro-carrying lymphocyte to the larger Ig-producing lymphocyte or plasma cell. | [
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10,001,051 | Serologic profile of alphamethyldopa-induced hemolytic anemia: correlation between cell-bound IgM and hemolysis. | [
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10,001,052 | Erythrocyte-bound immunoglobulins have been characterized by a PVP-potentiated antiglobulin test in 11 patients who had developed antibodies after treatment with alpha-methyldopa. Serologic profiles were recognized that could distinguish between the hemolyzing and nonhemolyzing patients: IgM antibodies together with the first component of complement (C1q) were demonstrated on erythrocytes of all eight hemolyzing patients. By contrast, these immunoproteins were absent from the cells of nonhemolyzing patients and became undetectable when the hemolyzing patients recovered. IgG and its subclasses were variably present on erythrocytes of all patients regardless of hemolytic activity. Eluates prepared from erythrocytes of the hemolyzing patients were shown to contain both IgG and IgM, and fixes C1q, C3, and C4. Eluates from the nonhemolyzing patients contained only IgG. The IgM antibodies differed from the commonly occurring cold agglutinins in that they were warm-reactive and were mainly concentrated on the patients' cells rather than being free in the serum. Because of their nonagglutinating property, it is suggested that they are monomeric IgM. It is concluded that the high affinity, warm-reactive IgM and not the IgG antibodies are primarily responsible for clinically manifest anemia in patients receiving alphamethyldopa and that the hemolytic activity is probably mediated by the classic pathway of complement activation. | [
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10,001,053 | Primary thrombocythemia: clonal origin of platelets, erythrocytes, and granulocytes in a GdB/GdMediterranean subject. | [
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10,001,054 | A patient with primary thrombocythemia, who was heterozygous for glucose-6-phosphate dehydrogenase deficiency (GdB/GdMed), was investigated to test for the clonal origin of this myeloproliferative disorder. In order to assess somatic cell mosaicism in various tissues, we have made use of the different rate of utilization of 2-deoxyglucose-6-phosphate, an analog of glucose-6-phosphate, by normal glucose-6-phosphate dehydrogenase and by the Mediterranean variant: the results demonstrate that essential thrombocythemia is a clonal disease involving the erythrocytic, granulocytic, and megakaryocytic series, without affecting monocytes, T lymphocytes, and non-T lymphocytes. | [
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] |
10,001,055 | Isolation and structural characterization of the polypeptide subunits of membrane glycoprotein IIb-IIIa from human platelets. | [
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10,001,056 | We have previously demonstrated the isolation of platelet membrane glycoprotein IIb-IIIa by affinity chromatography with a specific monoclonal antibody. We have now separated the polypeptide subunits IIb and IIIa of the isolated glycoprotein by preparative sodium dodecyl sulfate polyacrylamide gel electrophoresis and have compared their structural features. Both IIb and IIIa contain approximately 15% carbohydrate, but IIIa contains a larger percentage of mannose residues, suggesting the presence of high mannose as well as complex N-linked oligosaccharide chains. The amino acid compositions are sufficiently similar to imply areas of sequence homology between the two subunits. To examine further the relationship between the subunits, we digested a mixture of 125I-IIb and 131I-IIIa with trypsin and then separated the radiolabeled peptides by high performance liquid chromatography. The resultant peptide maps of IIb and IIIa are completely different. This indicates that neither subunit is derived from the other and suggests that polypeptides IIb and IIIa are products of separate genes. | [
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10,001,057 | [Adolescence and lung function (author's transl)]. | [
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10,001,058 | [Air pollution and chronic or repeated respiratory diseases. II. Results and discussion (author's transl)]. | [
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10,001,059 | The correlations between the concentrations of several air pollutants (sulphur oxides, suspended particles, nitrogen oxides) and ventilatory function and the prevalence of respiratory symptoms in 20 areas located in six French cities showed the following results : a) among adults of both sexes, the air concentration of SO2 is associated with the prevalence of lower respiratory symptoms, b) among children it is associated with the prevalence of upper respiratory symptoms, c) in both adults and children, the higher the SO2 pollution, the lower the forced expiratory volume in one second, d) no other pollutant is associated with ventilatory function and the prevalence of respiratory symptoms. The methods and results of this study are discussed and compared with those of other studies. | [
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10,001,060 | [Pressure-flow relationship in the airways (author's transl)]. | [
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10,001,061 | The perplexing features of the pressure-flow relationship in the pulmonary airways have been explained on the basis of a combined experimental-theoretical study. By systematically plotting the in vivo data on the pressure-flow relationship existing in the literature in a dimensionless manner (Moody diagram), we confirmed the results reported by Lisboa et al. [8] : contrary to the well-known theory of Jaffrin and Kesic [6], it appeared that under certain spontaneous breathing conditions Reynolds number is not the only parameter which governs the flow in the airways. We further confirmed this result using a cast of the central airways and a piston pump. The data showed that the pressure-flow relationship depended greatly on frequency, tidal volume and the physical properties of the gas used. After a systematic variation of these parameters, a dimensionless parameter epsilon, which depends importantly on local acceleration, was identified. This new parameter, together with those already identified (Re : Reynolds number; alpha : Womersley number), define the pressure-flow relationship in a given geometry during the course of a respiratory cycle. Implications of this theoretical knowledge on the measurement and interpretation of airway resistance are discussed. | [
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10,001,062 | Standard values of the maximal expiratory flow-volume curve normalized by total lung capacity. | [
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] |
10,001,063 | Standard values for the maximal expiratory flow-volume (MEFV) curve normalized by total lung capacity (TLC) were obtained in one hundred and fifty healthy men. We compared age dependency and the coefficient of variation of parameters of the MEFV curve, obtained at given percentages of the vital capacity and normalized by height to those of parameters obtained at given percentages of TLC and normalized by TLC (V %TLC/TLC). At low lung volumes, every parameter showed a larger age dependency and a larger coefficient of variation than at high lung volumes. V %TLC/TLC showed almost the same age dependency and almost the same coefficient of variation than the other parameters. However, in pulmonary patients, V %TLC/TLC seems to detect obstructive impairment more readily in spite of the changes in lung volume. It is suggested that V %TLC/TLC would be more helpful in screening for airflow limitation in various pulmonary disorders than other parameters. | [
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10,001,064 | Spirometry at adolescence. | [
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10,001,065 | Residual volume (RV), functional residual capacity (TGV) and total lung capacity (TLC) have been measured in 42 adolescents aged 16-22 years (22 young men and 20 young women) and in 60 children aged 12-15 years (29 boys and 31 girls) who were selected as having the same ranges of heights. TLC and TGV were related to height in each age and sex group; the slope of the regression curves did not differ between subgroups. RV was related to height in the boys and girls and not in the adolescents; however the number of subjects in each group was small. Relative to height the residual volumes of boys and girls were similar and in both sexes were larger than those for adolescents. Amongst the latter the values for young women were smaller than those for young men. The possible mechanisms are discussed. | [
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10,001,066 | Lung function changes as a reflection of tissue aging in young adults. | [
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10,001,067 | We studied 198 healthy young men and women 17 to 40 years of age, 110 blacks and 88 whites, all current non-smokers, with a view to identifying the changes, if any, consistent with lung tissue aging. Measurements were made of the maximal expiratory flow-volume (MEFV) curves (from which were derived forced vital capacity (FVC) and flow rates (Vmax) at 75%, 50% and 25% of expired VC), and transfer factor for carbon monoxide (TL). To describe aging trends, results were corrected for height differences and analysed by sex and race for five age groups. Certain changes (e.g. the age-related increase in FVC in men in the early 20's and decrease in the late 20's in both men and women) may be accounted for by changes in respiratory muscle force and/or increasing weight; in addition, the changes in FVC itself (used as the reference lung volume for reading flow rates off the MEFV curves) may have accounted in part for the age-related changes in Vmax at 75% and 50% VC. Likewise, increasing weight by influencing lung emptying may have contributed to the decrease in the diffusion constant in women. Only the age-related decline in Vmax at 25% VC (seen in women of both races and starting in the early 20's) could not be explained by the above factors, and may therefore reflect tissue aging. | [
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10,001,068 | [Physical fitness in diabetic adolescents (author's transl)]. | [
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10,001,069 | In 33 young diabetics, 10 to 17 years old, physical fitness was evaluated during exercise on a bicycle ergometer. Physical work capacity and maximal oxygen uptake are significantly lower in diabetics than in control subjects. The efficiency (W/VO2) is also significantly decreased in diabetic adolescents. These discrepancies might be explained by a lower physical training and an insufficient degree of metabolic control in diabetic patients. | [
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10,001,070 | The relation between radiological patterns of the breast and body weight and height. | [
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] |
10,001,071 | Mammograms were obtained from 942 normal volunteer women aged over 35 years, and were classified by Wolfe's criteria. There was no relationship between height and mammographic pattern. An increase in weight, whether corrected for height or not, was associated with an increase in the proportion of N grades and a concomitant decrease in DY grade mammograms. This effect reached formal significance in pre-menopausal women but was highly significant in post-menopausal women. For women who were either above or below their ideal weight there was a significant positive correlation between parity and the proportion of N and P1 mammograms. The slopes of the linear regression for these two groups were the same, although the elevation of the above-ideal weight group was significantly greater. This implies that for any given parity, there are about 16% more N or P1 grades in the above-ideal compared with the below-ideal weight group. | [
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10,001,072 | Percutaneous injection of contrast medium into breast lesions for radiographic exclusion of malignancy. | [
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10,001,073 | Contrast medium was injected percutaneously into palpable breast lesions in 63 patients in order to demonstrate lactiferous ducts. Of 35 benign and mammographically definable tumours, 30 were successfully punctured and ducts were visualized in 20, while ducts were demonstrated in seven of 21 non-definable lesions. Ducts were seen in 10 of 13 fibroadenomas removed by surgery, in two of four hamartomas, and in two of three cases of mastitis. No ducts were seen in six solid, malignant tumours examined, while one intracystic papillary carcinoma showed filling defects caused by the malignant growth. It was concluded that the method is simple, and that the demonstration of ducts is an indication of the benign nature of a lesion. | [
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10,001,074 | Upstream and total airway conductance in children and adolescents. | [
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10,001,075 | Static lung volumes, pressure-volume curves, airway conductance (Gaw) and maximum expiratory flow-volume curves were obtained in a group of healthy children and adolescents (age 6 to 17 years, body height 115 to 180 cm). Relating lung recoil pressure to maximum expiratory flow at the same lung volume level allowed the calculation of the conductance of the upstream segment (Gus). Gaw increased with increased body height and lung volume, so that specific Gaw did not change during growth. Gus also increased with body height, except at lower lung volume, but when corrected for simultaneous changes in lung volume it decreased. These physiological results suggest that the central airways grow proportionately to the changes in lung volume, whereas the growth of the peripheral airways is proportionately less marked. It is however not possible to draw definite conclusions on the isotropical or anisotropical growth of different parts of the lungs from these physiological observations. | [
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10,001,076 | Enzyme activities in skeletal muscle of 13-15 years old adolescents. | [
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10,001,077 | The activity of 22 enzymes of energy metabolism was determined in m. vastus lateralis quadricipitis of 14 adolescents aged 13-15 years (7 girls) and 14 adults aged 22 to 42 years (7 female subjects). The measurements were performed kinetically, at 37 degrees C, using optimal or near-to-optimal procedures. With the exception of one enzyme, enolase, no differences between sexes were observed in the two age groups. Glycolytic enzymes, including fructose-6-phosphate kinase, showed no significant differences in their activity in adults as compared to adolescents. The activity of enolase was lower in females of both age groups, but no difference due to age was found in this respect. Of the oxidative enzymes studied, only citrate synthase showed no significant difference in adults vs adolescents, whereas the activities of lipoamide dehydrogenase (+ 40%), NADP-isocitrate dehydrogenase (+ 44%), fumarase (+ 24.5%), total malate dehydrogenase (+ 42.2%) and NADH-dehydrogenase (+ 39%) were all significantly higher in the latter group. Aspartate aminotransferase was also 44% higher in adolescents. The possible physiological importance of these observations is discussed with regard to the functional capacity of the skeletal muscle. The hypothesis was considered that adolescents of this age may have a glycolytic capacity comparable to adults, but that they may oxidize pyruvate at a rate higher than adults. | [
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10,001,078 | Endoscopic retrograde cholangiography in post-operative bile duct strictures. | [
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10,001,079 | Spirometric predicted values for teenage boys: relation to body composition and exercise performance. | [
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10,001,080 | Forced expiratory volume and vital capacity of 428 healthy adolescent boys have been related to the age, body size, body composition, athletic prowess and maximal oxygen uptake. After allowing for age and height the lung function is related to the fat free mass and index of muscularity (fat free mass/height 2) but not to the other indices. This finding contributes to the derivation of reference values and to understanding the factors which promote the development of the lungs during adolescence. | [
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10,001,081 | Plethysmography study and pulmonary function in well-trained adolescents. | [
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] |
10,001,082 | The values of lung volumes (VC, FRC, TGV, FEV1.0, etc.) and airway resistances (Raw, Raw) were measured by the spirometry and plethysmography method in 35 physically well trained, healthy adolescents, aged 14 to 20 years, boys and girls coming from various schools from the Grenoble area. The data were correlated with body height and some also with age or weight through linear, exponential or power law relationships. All volumes increased with height (Ht), which was the best independent variable, with some preference for a linear representation. However the increase of lung volumes with height was also well reproduced by an exponential function proportional for all volumes to e0.020Ht in good agreement with recent results obtained for young children. Some significant sex differences were observed for lung volumes. Airway resistance measured by two different methods (Raw and Raw) decreased with height with some preference for a linear relationship. The mean airway resistance (Raw) obtained from a complete inspiration-expiration curve while the subject breathed at his own spontaneous breathing rate was systematically smaller (from 0.5 to 1 cmH2O/l/s) than Raw measured by a technique similar to the panting method. No sex differences for airway resistances or conductances were observed. Specific airway conductance was found to be age and height independent. | [
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10,001,083 | Intracavitary irradiation of endometrial carcinomas of the uterus in stage I using a "bulb technique": physical basis. | [
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10,001,084 | Enlargement of carotid bodies in rats with lung emphysema or silicosis. | [
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10,001,085 | Volume of carotid bodies was measured morphometrically in rats with experimental lung emphysema or silicosis. The mean volume of the left carotid body was 19.9 +/- (SD) 12.4 in 13 control rats, 30.7 +/- 12.5 in 9 rats with lung emphysema, and 41 +/- 18.9 . 10(6) micrometer 3 in 10 rats with lung silicosis. There was no correlation between carotid body volume and pulmonary arterial blood pressure. A good correlation was found between the volume of carotid body and partial pressure of oxygen in arterial blood. The functional meaning of the increase of volume of carotid bodies in rats with chronic respiratory insufficiency remains unclear. | [
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10,001,086 | Radiation dosimetry survey of computed tomography systems from ten manufacturers. | [
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] |
10,001,087 | Profiles of the absorbed dose delivered throughout cylindrical and anthropomorphic phantoms during single scans by computed tomography systems from ten manufacturers were measured using LiF thermoluminescent dosemeters (TLD) and X-ray therapy verification film. The dose profiles demonstrate that a significant portion of the dose is delivered outside the imaged volume of a single scan. The doses measured in cylindrical Plexiglas phantoms were similar to those measured in anthropomorphic cross sections of tissue substitute materials except near the centre of the thorax section. The film results, obtained using a single calibration curve, agreed with the TLD results to within 25% for most systems. | [
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10,001,088 | [Lung function and gastroesophageal reflux during chronic bronchitis (author's transl)]. | [
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10,001,089 | The coexistence of gastroesophageal reflux (GER) and respiratory diseases has led us to raise three questions : 1) how frequent is GER in patients with chronic bronchitis?, 2) is the respiratory function in patients with chronic bronchitis different when they have a GER and when they do not?, 3) is the GER different in patients with chronic bronchitis and in subjects not suffering with chronic bronchitis? The study of esophageal pH after a test meal showed there was a GER in 29 out of the 47 patients studied. The measurements of lung volume, air flow, pulmonary compliance, as well as the alveolo-capillary transfer of carbon monoxide, showed that there was no difference in the lung function of bronchitics whether they had a reflux or not. On the other hand, refluxes are less frequent but longer in patients having bronchitis and a GER, than in those having a GER but not having bronchitis. This must be linked to a low esophageal clearance which could be related to the attack of bronchitis. Only a well carried out prospective study of the treatment of GER in patients will reveal if the reflux increases bronchitic symptoms. | [
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10,001,090 | Scattered radiation distributions around computed tomography scanners and the associated radiation hazard to personnel. | [
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10,001,091 | [Air pollution and chronic respiratory disease. I. Methods and material (author's transl)]. | [
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] |
10,001,092 | In order to assess the relationships of air pollution to ventilatory function and to the prevalence of respiratory symptoms, a French national survey was conducted from 1974 to 1976 in 28 areas located in 7 cities (Bordeaux, Lille, Lyons, Mantes, Marseilles, Rouen, Toulouse) and a newly industrialized region (Fos-Berre). The following pollutants were measured : SO2 (specific and acidimetric methods), suspended particulates (gravimetric method and smoke), NO2 and NO. Subjects were men and women, not manual workers, aged 25-59, and children aged 6-10. Ventilatory function was measured with a dry expirograph (Vitalograph) and respiratory symptoms were obtained from a standardized questionnaire. There were large variations between areas in the measured pollution concentrations. The extreme values were, for SO2 (specific) 22 and 85 microgram/m3, for SO2 (acidimetric) 13 and 127 microgram/m3, for suspended particles (gravimetric) 45 and 243 microgram/m3, for suspended particles (smoke) 21 and 152 microgram/m3, for NO2 12 and 61 microgram/m3 and for NO 7 and 140 microgram/m3. 19191 subjects were examined (7581 men, 9083 women, 1291 boys and 1236 girls). Besides the well known relationships of age and smoking to ventilatory function and the prevalence of respiratory symptoms, less well established results appeared, in particular the importance of moderate work-related exposure. The influence of pollution will be the subject of the second part of this work. | [
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10,001,094 | Direct coronal mode (DCM) in whole-body CT scanning. | [
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] |
10,001,095 | Left atrial myxoma diagnosed by computerized tomography. | [
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10,001,096 | Intracranial epidural abscess. | [
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] |
10,001,097 | T-tube calculus--report of a case. | [
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10,001,098 | A new method for studying barium sulphate contrast media in vitro. | [
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10,001,099 | Gastric hypermotility and antropyloric dysfunction in gastric ulcer patients. | [
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