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10,001,200 | Chemoprevention by retinoids of the progression of carcinomas induced in rats by azaserine was evaluated. Wistar/Lewis rats were given 15 weekly injections of azaserine, 10 mg/kg, while fed a chow diet; after the completion of carcinogen treatment, they were fed a chow diet supplemented with four different retinoids at... | [
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10,001,201 | Phorbol myristate acetate-induced adherence of Walker 256 carcinosarcoma cells. | [
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10,001,202 | Treatment of nonadherent Walker 256 carcinosarcoma cells with phorbol myristate acetate (PMA) causes these cells to become adherent to noncellular foreign surfaces such as nylon fibers and plastic culture dishes and to monolayers of endothelial cells. Increased adherence is first observed after a short lag period (5 to... | [
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10,001,203 | Induction of lymphoma in antigenically stimulated athymic mice. | [
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10,001,204 | Athymic mice infected with pinworms or carrying human tumor xenografts frequently develop a lymphoproliferative disorder which eventually leads to lymphoma. By immunofluorescent analysis of involved tissues, the lymphomas appear to be mixtures of null cells, B-cells, and T-cells. When each lymphoma is established in ti... | [
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10,001,205 | Influence of convection in the growth medium on oxygen tensions in multicellular tumor spheroids. | [
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10,001,206 | Tumorigenicity of bay-region diol-epoxides and other benzo-ring derivatives of dibenzo(a,h)pyrene and dibenzo(a,i)pyrene on mouse skin and in newborn mice. | [
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10,001,207 | Excessive accumulation of autofluorescent lipofuscin in the liver during hepatocarcinogenesis by methyl clofenapate and other hypolipidemic peroxisome proliferators. | [
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10,001,208 | Inhibitory effects of four isoabrins on the growth of sarcoma 180 cells. | [
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10,001,209 | The four isoabrins were shown to be capable of inhibiting the growth of tumor cells in vivo when one-fifth of their median lethal dose was used. From the in vitro experiments, the doses required for 50% inhibition of protein biosynthesis are 3.2 pg, 45 ng, 32 ng, and 10 ng/ml for abrin-a, -b, -3, and -d, respectively. ... | [
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10,001,210 | Differential effect of imidazole antibiotics on untransformed and virus-transformed rat cell lines. | [
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10,001,211 | The imidazole antimycotics clotrimazole and miconazole were tested on untransformed rat cell line 3Y1-B clone 1-6 (3Y1) and six transformed cell lines, which were independently isolated from 3Y1 or 3Y1-B clone 1 after infection with adenovirus 12 (AD-12) or with SV40, to determine their sensitivities to these drugs. Th... | [
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10,001,212 | Alteration of the survival response of two human colon carcinoma subpopulations to x-irradiation by N,N-dimethylformamide. | [
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10,001,213 | Reproducible growth in tissue culture of retinoblastoma tumor specimens. | [
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10,001,214 | Retinoblastoma is a unique embryonic tumor which frequently arises because of an autosomal dominantly inherited mutation. Study of the genetic changes associated with retinoblastomas requires techniques that allow proliferation of fresh tumor specimens in tissue culture. However, until the present study, there were no ... | [
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10,001,215 | Reduction of adriamycin toxicity by ascorbate in mice and guinea pigs. | [
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10,001,216 | The effect of ascorbate in reducing Adriamycin toxicity has been examined in mice and guinea pigs. Ascorbate had no effect on the antitumor activity of Adriamycin in mice inoculated with leukemia L1210, but it significantly prolonged the life of mice and guinea pigs treated with Adriamycin. Adriamycin elevated lipid pe... | [
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10,001,217 | Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth. | [
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10,001,218 | The binding of [3H]tamoxifen ([3H]Tam), a nonsteroidal antiestrogen, and of 4-[3H]hydroxytamoxifen ([3H]OH-Tam), a metabolite accumulated in vivo in target cell nuclei, was characterized in soluble extracts of human breast cancer MCF7 cells growing in a medium depleted in estrogens. Saturation analysis indicated a much... | [
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10,001,219 | Effect of beta-glucuronidase inhibitor on azoxymethane-induced colonic carcinogenesis in rats. | [
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10,001,220 | In this study of the role of microfloral beta-glucuronidase in colonic carcinogenesis, the effect of beta-glucuronidase inhibitor was evaluated. Starting at 5 weeks of age, male Donryu rats were fed either a semisynthetic diet or the same diet containing 0.1% beta-glucuronidase inhibitor as N-cyclohexyl-5-O-acetyl-2,4-... | [
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10,001,221 | Surface marker identification of small cleaved follicular center cell lymphomas with a highly favorable prognosis. | [
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10,001,222 | Between 1976 and 1980, 143 cases of non-Hodgkin's lymphoma have been prospectively analyzed for correlations between surface marker phenotype, histomorphology, and prognosis. This study analyzed 44 adults with tumors classified by Lukes-Collins criteria as small cleaved follicular center cell lymphomas. Two surface mar... | [
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10,001,223 | Phase I clinical trial of 9,10-anthracene dicarboxaldehyde (Bisantrene) administered in a five-day schedule. | [
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10,001,224 | Bisantrene is a substituted anthracene derivative which preclinically demonstrated a spectrum of activity similar to that of doxorubicin but without associated cardiotoxicity. A Phase I evaluation of the drug has been performed using daily i.v. administrations for 5 days. Sixty courses of treatment were administered to... | [
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10,001,225 | Effect of estrogen and progesterone on cellular replication of human breast tumors. | [
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10,001,226 | A total of 54 infiltrating carcinomas of the breast were studied for estrogen receptor concentration in the tumor cytosol and thymidine-labeling indexes. The results showed that there was no significant difference in the level of thymidine-labeling index between 22 primary and 32 metastatic breast cancers. No significa... | [
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10,001,227 | Relationship between natural killer cell activity and histological features of lymphocyte infiltration and partial regression of the primary tumor in melanoma patients. | [
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10,001,228 | A group of 194 melanoma patients with Stage I melanoma was studied in an attempt to correlate histological features of prognostic importance in malignant melanoma with the level of natural killer cell (NK) activity in blood mononuclear cells. Histological features examined were lymphocytic infiltrate of the tumor base,... | [
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10,001,229 | Membrane glycopeptides from chemically transformed cells: comparison between mesenchymal and epithelial cell lines derived from dimethylnitrosamine-treated rat kidney. | [
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10,001,230 | Radiation-induced mammary carcinogenesis in virgin, pregnant, lactating, and postlactating rats. | [
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10,001,231 | Comparative metabolism of 2,6-dimethylnitrosomorpholine in rats, hamsters, and guinea pigs. | [
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10,001,232 | The metabolism of N-[3,5-3H]nitroso-2,6-dimethylmorpholine (NDMM) was studied in female Sprague-Dawley rats. Syrian golden hamsters, and guinea pigs. NDMM induces tumors in the esophagus in rats, pancreatic cancer in hamsters, and hemangioendothelial tumors of the liver in guinea pigs. An intragastric dose of NDMM (2 m... | [
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10,001,233 | Comparison of the in vitro metabolism of N-nitrosohexamethyleneimine by rat liver and lung microsomal fractions. | [
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10,001,234 | The in vitro metabolism of N-nitrosohexamethyleneimine by lung and liver microsomes and cytosol from uninduced male Fischer rats is described. Metabolites produced by both organs appeared to be identical. The liver subcellular fractions had a lower Km (0.6 mM) than did lung fractions (3 mM) and metabolized 2.5 to 5 tim... | [
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10,001,235 | Effect of regenerative hyperplasia on the urinary bladder: carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. | [
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0.0... |
10,001,236 | Different activities of unscheduled DNA synthesis in human melanoma and bone marrow cells. | [
-0.05542141571640968,
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... |
10,001,237 | Unscheduled DNA synthesis (UDS) indicated by melphalan was studied in freshly collected tumor cells from human melanoma metastases. Comparative studies were done on human bone marrow blast cells. Significant levels of UDS comparable with those in myeloblasts were found in only two of eight melanoma cell populations. Th... | [
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10,001,238 | Effect of 1,2-dimethylhydrazine and diethylnitrosamine on cell replication and unscheduled DNA synthesis in target and nontarget cell populations in rat liver following chronic administration. | [
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10,001,239 | Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol. | [
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10,001,240 | Effects of capsaicin and bradykinin on afferent fibers with ending in skeletal muscle. | [
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10,001,241 | Capsaicin, injected into the arterial supply of the skinned hindlimb of dogs, evokes reflex increases in cardiovascular function. Moreover, the cardiovascular reflexes evoked by capsaicin are very similar to those evoked by static exercise. The afferent fibers initiating these reflex increases have not been identified ... | [
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10,001,242 | "Electrical activity from the sinus node region in conscious dogs". | [
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10,001,243 | Hyperemic response of the coronary circulation to brief diastolic occlusion in the conscious dog. | [
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0.03... |
10,001,244 | This study was undertaken to determine whether coronary blood flow can be regulated in response to coronary arterial occlusions briefer than a single diastole. The possible involvement of metabolic vs. myogenic mechanisms in such regulation was investigated. Eleven conscious dogs with experimentally produced complete h... | [
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10,001,245 | Coronary vasodilation after a single ventricular extra-activation in the conscious dog. | [
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0.0517... |
10,001,246 | This study was undertaken to determine if coronary blood flow can be regulated in response to a transient increase in cardiac metabolic demand. Eight conscious dogs with experimentally produced complete heart block, a chronically implanted electromagnetic flow probe on the left circumflex coronary artery, and fluid-fil... | [
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10,001,247 | A dynamic electrical record of the pathway of human His bundle activation from surface mapping. | [
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10,001,248 | Body surface potential maps of human His bundle activity have been difficult to product for two reasons: (1) The peak surface potentials are often less than 5 muv, and (2) the simultaneous atrial repolarization potentials frequently exceed 100 muv. We have therefore amplified surface signals 25 times the standard gain ... | [
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10,001,249 | Left ventricular energetics. Heat loss and temperature distribution of canine myocardium. | [
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10,001,250 | The sum of total left ventricular heat loss and left ventricular mean total external power was compared with the product of oxygen consumption and its energy equivalent. Myocardial blood flow, measured with 15 +/- 3 micrometers radioactive microspheres, was multiplied by the transcoronary arteriovenous temperature diff... | [
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10,001,251 | The effects of peripheral impedance and inotropic state on the power output of the left ventricle in dogs. | [
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10,001,252 | The power output of the left ventricle as measured by the product of the Fourier components of aortic pressure and aortic flow is linked by definition to the arterial impedance facing the heart as measured by the quotient of these components. Consequently, the use of power measurements to assess ventricular performance... | [
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0.02... |
10,001,253 | Mechanical interactions between four heart chambers with and without the pericardium in canine hearts. | [
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10,001,254 | By using excised postmortem hearts obtained from 15 mongrel dogs with the pericardium intact, we investigated mechanical interactions between the four heart chambers from the standpoint of ventricular pressure-volume relationships. The interactions investigated were those between (1) the atrium and the ventricle, (2) t... | [
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10,001,255 | Assessment of jeopardized myocardium in patients with one-vessel disease. | [
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0.0763... |
10,001,256 | Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation? | [
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0.06... |
10,001,257 | In 67 dogs with a 60-80% coronary stenosis produced by an external constricting plastic ring, blood flow measured with an electromagnetic flowmeter showed cyclical flow reductions of varying magnitude and duration, and then an abrupt return to control flow. In 45 dogs, heparin did not prevent these flow reductions, but... | [
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10,001,258 | Determinants of arrhythmic death due to coronary spasm: effect of preexisting coronary artery stenosis on the incidence of reperfusion arrhythmia. | [
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0.008... |
10,001,259 | Coronary spasm can occur in the presence or absence of coronary artery disease. We therefore determined the effect of preexisting coronary stenosis on the incidence of ventricular fibrillation during reperfusion after circumflex artery (CFX) occlusion. Twenty dogs underwent a 30-minute open-chest CFX occlusion. During ... | [
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0.0966849... |
10,001,260 | Exercise testing in patients with variant angina: results, correlation with clinical and angiographic features and prognostic significance. | [
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10,001,261 | Eighty-two patients with variant angina underwent a treadmill exercise test using 14 ECG leads, and 67 also underwent exercise thallium-201 scans. The test induced ST elevation in 25 patients (30%), ST depression in 21 (26%) and no ST-segment abnormality in 36 (44%). ST elevation during exercise occurred in the same EC... | [
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0.0055... |
10,001,262 | Postinfarction angina caused by coronary arterial spasm. | [
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0.06... |
10,001,263 | Recurrent ST-segment elevations in leads where new Q waves developed were repeatedly recorded in six patients during a recovery phase of acute myocardial infarction. Such ST-segment elevations were transient, occurred with or without chest pain, and returned to control levels. No enzymatic changes signifying recurrent ... | [
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0.... |
10,001,264 | Relationship of blood pressure in 20-39-year-old men to subsequent blood pressure and incidence of hypertension over a 30-year observation period. | [
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... |
10,001,265 | The objective of this investigation was to determine the relationship of blood pressure (BP) in young men, ages 20-39 years, to their subsequent BP from the perspective of BP tracking, position in BP distribution and later evidence of hypertensive BP values. Since 1948, the Manitoba Study group has followed 3983 men, 9... | [
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... |
10,001,266 | Coronary artery disease mortality in relatives of hypertriglyceridemic school children: the Muscatine study. | [
0.028922487050294876,
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0.0071... |
10,001,267 | From 2655 healthy school children participating in the 1973 and 1975 Muscatine Coronary Risk Factor School surveys, two groups of index cases were selected for a detailed family study of coronary mortality: a group with fasting triglyceride levels greater than the ninetieth percentile on both surveys (n = 75) and a gro... | [
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-0.00... |
10,001,268 | Tellurium-123m-labeled-9-telluraheptadecanoic acid: a possible cardiac imaging agent. | [
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0.011145230382680893,
0.0667... |
10,001,269 | Factors that affect the reproducibility of measurements of left ventricular function from first-pass radionuclide ventriculograms. | [
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0.0... |
10,001,270 | To examine which factors affect the reproducibility of ejection fraction (EF), pulmonary transit time (PTT) and segmental wall motion assessed from first-pass radionuclide angiograms (FPRA), 32 patients who had FPRA were randomized for site of injection of isotope (right or left arm) and projection (right or left anter... | [
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0.076... |
10,001,271 | Immediate diagnosis of acute myocardial infarction by two-dimensional echocardiography. | [
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0.05961... |
10,001,272 | To define the role of portable two-dimensional echocardiography (2-D echo) in the immediate diagnosis of acute chest pain syndrome, 80 consecutive patients were studied. Adequate 2-D echo studies were obtained in 65 (81%). Thirty-three patients had clinical evidence of transmural or nontransmural acute myocardial infar... | [
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0.04736265912652016,
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-0.022837558761239052,
-0.04183846339583397,
-0.050619423389434814,
0.04352... |
10,001,273 | Right atrial pacing soon after myocardial infarction. | [
-0.08750908076763153,
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-0.07348863780498505,
0.11883009970188141,
0.07274424284696579,
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0.06978905946016312,
0.07735095173120499,
-0.025274451822042465,
0.051... |
10,001,274 | Esophageal pacing: a diagnostic and therapeutic tool. | [
0.04191793128848076,
0.029529476538300514,
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0.036399561911821365,
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0.04129697009921074,
0.0093... |
10,001,275 | Evaluation of a QRS scoring system for estimating myocardial infarct size. I. Specificity and observer agreement. | [
0.009166830219328403,
0.027014322578907013,
0.019845331087708473,
0.03582931309938431,
0.054597143083810806,
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0.004225756507366896,
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0.1146... |
10,001,276 | We evaluated a simplified version of a previously developed QRS scoring system for estimating infarct size using observations of Q- and R-wave durations and R/Q and R/S amplitude ratios in the standard 12-lead ECG. Groups of subjects with a minimal likelihood of having myocardial infarcts and minimal likelihood of havi... | [
-0.03279784694314003,
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-0.01969778537750244,
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-0.02877209708094597,
0.089... |
10,001,277 | Acceleration of the ventricular response during atrial fibrillation in the Wolff-Parkinson-White syndrome after verapamil. | [
0.0019568551797419786,
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0.12032575905323029,
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0.008162738755345345,
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-0.03875434398651123,
0.0535... |
10,001,278 | We examined the electrophysiologic effects of verapamil in eight patients with the Wolff-Parkinson-White syndrome. Verapamil shortened the antegrade effective refractory period of the accessory pathway in three patients and abbreviated the shortest cycle length with 1:1 conduction over the accessory pathway in two pati... | [
0.004314281977713108,
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0.00026178426924161613,
-0.018336104229092598,
0.01578955352306366,
0.076361164... |
10,001,279 | Procainamide and retrograde atrioventricular nodal conduction in man. | [
0.005030161701142788,
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0.03700288012623787,
0.08648136258125305,
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0.057... |
10,001,280 | Recent studies that show a depressant effect of procainamide (PA) on retrograde conduction in patients with atrioventricular (AV) nodal reentrant tachycardia (RT) have suggested possible incorporation of AV nodal bypass tracts. Electrophysiologic effects of i.v. PA, 10 mg/kg, on retrograde AV nodal conduction were exam... | [
0.011376011185348034,
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0.024563493207097054,
0.09441234171390533,
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-0.001439483487047255,
-... |
10,001,281 | Pirmenol, a new antiarrhythmic agent: initial study of efficacy, safety and pharmacokinetics. | [
-0.039777714759111404,
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-0.05712316930294037,
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0.03... |
10,001,282 | Pirmenol (CI-845), a new antiarrhythmic drug, was studied for the first time in humans to establish a minimum effective i.v. dose in 10 patients with chronic, stable premature ventricular complexes (PVCs) and to evaluate toxicity and pharmacokinetics. Infusions of 70-150 mg were associated with a 90% or greater reducti... | [
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0.0... |
10,001,283 | Sequelae of the initial attack of acute rheumatic fever in children from north India. A prospective 5-year follow-up study. | [
0.04473065212368965,
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0.07798080891370773,
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0.0393514558672905,
0.0018356437794864178,
0.024825409054756165,
0.058062635362148285,
0.0944405... |
10,001,284 | We determined the outcome of acute rheumatic fever in 85 children from North India who had received regular antistreptococcal prophylaxis after their first attack. By the end of the 5-year follow-up, 33 patients had rheumatic heart disease. Mitral insufficiency, the most common valvular lesion, appeared in 91% of the p... | [
0.03469051793217659,
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0.05877404287457466,
0.050493642687797546,
0.056895457208156586,
0.090889... |
10,001,285 | Overestimation of pediatric cardiac output by thermal indicator loss. | [
0.021143270656466484,
0.06887035071849823,
0.025424068793654442,
0.07690893858671188,
0.0499989278614521,
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0.011414969339966774,
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0.026919057592749596,
0.0542... |
10,001,286 | The accurate measurement of pediatric cardiac output by thermodilution requires that the quantity of cold indicator introduced into the central circulation be known. This study defines an important source of error in the correction factor for the amount of heat gained by small volumes of cold injectate during passage t... | [
0.0305628664791584,
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0.029379142448306084,
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-0.04917104169726372,
0.06319126486778259,
0.0726... |
10,001,287 | Right ventricular dysplasia: a report of 24 adult cases. | [
0.007021272089332342,
0.05272524803876877,
0.029192674905061722,
0.05687820911407471,
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0.03694596886634827,
0.020986607298254967,
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0.0... |
10,001,288 | Right ventricular dysplasia is characterized by an abnormality in the development of part of the right ventricular musculature. Patients with right ventricular dysplasia may present with ventricular tachycardia, supraventricular arrhythmias, right-heart failure or asymptomatic cardiomegaly. Twenty-two adult patients wi... | [
0.03990126773715019,
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0.04981778934597969,
0.03704799339175224,
-0.06051875278353691,
0.013632864... |
10,001,289 | Late survival and symptoms after repair of tetralogy of Fallot. | [
0.048173628747463226,
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0.03372098505496979,
0.01870289258658886,
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0.031... |
10,001,290 | The long-term results of 414 patients who underwent repair of tetralogy of Fallot between 1967 and 1977 were studied and correlated with the results of others. There were nine late deaths (8-year actuarial survival 95.8%). Six of the deaths wee directly related to the malformation or its treatment. Eight patients (2.4%... | [
0.002926379209384322,
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-0.04365712031722069,
-0.011689115315675735,
0.06... |
10,001,291 | Comparison of synthetic and natural glucosylceramides as substrate for glucosylceramidase assay. | [
0.08904392272233963,
-0.11078394204378128,
-0.05962991714477539,
-0.03818817809224129,
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0.06260693818330765,
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0.016773875802755356,
0.07651279121637344,
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-0.06921519339084625,
0.01866543... |
10,001,292 | Commercially available [3H]glucosylceramide is derived from spleen tissue of patients with Gaucher's disease. When such tritiated glucosylceramide was diluted with unlabelled glucosylceramide from different sources and used as the substrate for assays of glucosylceramidase, the apparent activities obtained differed dra... | [
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0.11051756888628006,
0.04481184855103493,
-0.05255599692463875,
0.0120... |
10,001,293 | Determination of phosphatidylglycerol in amniotic fluid by a simple one-dimensional thin-layer chromatography method. | [
0.011200593784451485,
-0.014151903800666332,
-0.021841980516910553,
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0.010739979334175587,
0.050165869295597076,
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-0.057354964315891266,... |
10,001,294 | Phosphatidylglycerol (PG) in amniotic fluid is the second important component of lung surfactant phospholipids and may be clinically useful in assessing fetal lung maturity in utero. Although methods for PG determination are available, there are shortcomings in clinical application. We developed an alternative reliable... | [
0.012901423498988152,
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0.02802145667374134,
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0.031231218948960304,
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-0.024904917925596237,
-0.06362106651067734,
0... |
10,001,295 | Phospholipid enhances triglyceride quantitation using an enzyme kit methods. | [
-0.026229120790958405,
-0.06551086157560349,
-0.07932460308074951,
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0.051667120307683945,
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-0.1269223690032959,
0.... |
10,001,296 | Covalent linkage of antisera to microparticulate cellulose using 1,1'-carbonyldiimidazole: a rapid, practical method with potential use in solid-phase immunoassay. | [
0.04104291647672653,
-0.035384152084589005,
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0.09126647561788559,
0.09393997490406036,
0.011563542298972607,
-0.0775185152888298,
0.085308... |
10,001,297 | Determination of human serum placental alkaline phosphatase, using theophylline inhibition. | [
-0.011394022963941097,
0.006413491442799568,
-0.010558102279901505,
-0.03040664829313755,
0.07285906374454498,
0.07562299072742462,
0.027424488216638565,
0.14533597230911255,
0.006969593930989504,
0.0482960119843483,
-0.05066486820578575,
-0.027818908914923668,
-0.10208995640277863,
0.0449... |
10,001,298 | Comparison of the polypeptide composition of cystic fibrosis plasma with normal plasma by high resolution electrophoresis. | [
0.022277656942605972,
-0.07059532403945923,
-0.009011215530335903,
0.009618882089853287,
0.028547773137688637,
0.049960289150476456,
0.09360823780298233,
0.13354958593845367,
0.049118563532829285,
0.01995733752846718,
-0.015374436043202877,
-0.023907797411084175,
-0.03850308060646057,
0.11... |
10,001,299 | Cystic fibrosis and normal plasma proteins were compared by the method of high resolution two-dimensional electrophoresis in polyacrylamide gels. For the first dimension, samples were treated with urea and dithiothreitol and then subjected to isoelectric focusing in pH gradients of 3.5-10.0 or 5.0-8.0. The second dimen... | [
-0.0053428770042955875,
-0.07901298999786377,
0.03212045505642891,
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0.025920450687408447,
0.045520663261413574,
0.09422403573989868,
0.033519551157951355,
0.021179908886551857,
0.034479256719350815,
-0.0057692378759384155,
0.036009423434734344,
... |
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