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10,004,200 | A monoclonal antibody (CALed) against a human pulmonary squamous cell carcinoma line was cytotoxic to the line but did not react to an autologous B-lymphoblastoid line. Although the antibody was thought to be cancer specific, principally on the basis of this evidence, the antibody actually had the A1 Lewis d (Led) spec... | [
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10,004,201 | Stimulation of DNA synthesis and cell proliferation in the liver of rats fed a choline-devoid diet and their suppression by phenobarbital. | [
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10,004,202 | Feeding of choline-devoid (CD) diet and dietary administration of phenobarbital (PHB) are efficient promoters of liver carcinogenesis in the rat. Furthermore, inclusion of PHB in a CD diet results in a synergistic effect, inasmuch as the promoting action of their combination is greater than the sum of those exerted by ... | [
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10,004,203 | Association of impaired immune responsiveness of lymphocytes from animals bearing large tumors with a membrane-bound suppressive substance. | [
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10,004,204 | The immunoreactivity of lymphocytes from mice bearing large tumors was investigated. As compared to normal lymphocytes, lymphocytes from tumor bearers manifested a lessened proliferative response to T-cell mitogens and were less capable of destroying syngeneic tumor target cells. However, the impaired reactivity of the... | [
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10,004,205 | Molecular basis for increased synthesis of albumin in rat liver after thioacetamide administration. | [
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10,004,206 | Administration of thioacetamide to rats for 4 days has been shown previously to increase the activity of liver messenger RNA (mRNA) and to disproportionately increase the activity of albumin mRNA in the wheat germ translation system. We have explored the possibility that administration of thioacetamide quantitatively a... | [
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10,004,207 | Effect of the suspected tumor promoters saccharin, cyclamate, and phenol on nerve growth factor binding and response in cultured embryonic chick ganglia. | [
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10,004,208 | The suspected bladder tumor promoters saccharin and cyclamate reversibly inhibited nerve growth factor-induced neurite outgrowth in embryonic chick sensory ganglia, and active concentrations of these artificial sweeteners inhibited binding of 125I-labeled mouse submaxillary gland nerve growth factor as well. The skin t... | [
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10,004,209 | Paradoxical effect of radiation on tumor incidence in the rat: implications for radiation therapy. | [
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10,004,210 | The high incidence of leukemia in the Fischer rat is reduced by radiation to an incidence below that seen spontaneously. Fractionating the radiation decreased this effect. In contrast, mammary tumors increased with dose until reaching a plateau at the highest doses. Fractionation had little effect. These results are co... | [
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10,004,211 | Activity of a novel anthracenyl bishydrazone, 9,10-anthracenedicarboxyaldehyde Bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride, against experimental tumors in mice. | [
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10,004,212 | 9,10-Anthracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride (CL 216942; bisantrene hydrochloride; NSC 337766), a member of a new chemical class of compounds with antineoplastic properties, has been evaluated for antitumor activity in experimental murine tumor systems. The compound produ... | [
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10,004,213 | Enhanced transformation of mouse 10T1/2 cells by 12-O-tetradecanoylphorbol-13-acetate following exposure to X-rays or to fission-spectrum neutrons. | [
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10,004,214 | Addition of the tumor promoter of 12-O-tetradecanoylphorbol-13-acetate (TPA) to C3H/10T1/2 cells after exposure to either X-rays or to fission-spectrum neutrons increases significantly the frequency of transformation without any effect on cell survival. However, treatment of unirradiated cells with 0.1 micrograms of TP... | [
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10,004,215 | Involvement of macrophages in the eradication of established metastases following intravenous injection of liposomes containing macrophage activators. | [
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10,004,216 | Liposomes containing encapsulated lymphokines or muramyl dipeptide (MDP), when injected i.v. into C57BL/6 mice, produced significant destruction of established lung and lymph node metastases from a s.c. highly metastatic B16-BL6 melanoma. We present evidence that eradication of the metastases is mediated by the activat... | [
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10,004,217 | Fluoresceinated estrone binding by human and mouse breast cancer cells. | [
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10,004,218 | Chlorpromazine distribution in hamsters and mice bearing transplantable melanoma. | [
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10,004,219 | Chlorpromazine (CPZ) distribution was measured in tissues of Syrian golden hamsters bearing Greene melanoma and in BALB/c mice bearing Harding-Passey melanoma. Distribution was evaluated as a function of time (0.5 to 14 days) and as a function of single and multiple doses (up to five) of from 5 to 50 mg CPZ per kg body... | [
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10,004,220 | Induction of alkaline phosphatase activity in cultured human intracranial tumor cells. | [
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10,004,221 | Alkaline phosphatase activity in several cultured primary human intracranial tumor cells varied over a relatively wide range, and there was no correlation between specific activity and the type of tumor from which the cultures were derived. The enzyme was thermolabile, and its activity was strongly inhibited by l-bromo... | [
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10,004,222 | Expression of the tumor aldehyde dehydrogenase phenotype during 2-acetylaminofluorene-induced rat hepatocarcinogenesis. | [
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10,004,223 | In aromatic amine-induced rat hepatomas, the aldehyde dehydrogenase (AIDH) phenotype is qualitatively and quantitatively different from that of normal liver. To identify the mechanism(s) underlying the expression of the tumor-specific AIDHs, we have followed the time course of appearance of the new phenotype during hep... | [
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10,004,224 | Comparative physiological disposition of N-(phosphonacetyl)-L-aspartate in several animal species after intravenous and oral administration. | [
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10,004,225 | The physiological disposition of N-(phosphonacetyl)-L-aspartate (NSC 224131; PALA), a potent inhibitor of aspartate transcarbamylase, has been studied in mouse, rat, dog, and monkey after administration of [14C]PALA at 120 mg/sq m i.v. or p.o. Concentrations of PALA equivalents in plasma, urine, and feces were determin... | [
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10,004,226 | Purification and partial characterization of a 17 beta-estradiol-binding macromolecule in the human pancreas. | [
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10,004,227 | Studies have been performed in order to investigate the presence of estrogen-binding proteins in the human pancreas that may provide the biochemical basis for tissue-specific treatment of pancreatic carcinoma with estrogen-based cytotoxic drugs. Using in vitro techniques, an estrogen-binding macromolecule has been puri... | [
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10,004,228 | Protection of mice against lethal doses of 1 beta-D-arabinofuranosylcytosine by pluripotent stem cell inhibitors. | [
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10,004,229 | The aim of this work was to study whether an inhibitor of pluripotent stem cell (CFU-S) recruitment, which we have shown previously to be able to increase the number of CFU-S after a fractionated treatment with 1-beta-D-arabinofuranosylcytosine, could increase the survival of mice given injections of lethal doses of th... | [
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10,004,230 | Effect of estradiol on the ultrastructure of the MCF7 human breast cancer cells in culture. | [
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10,004,231 | We have analyzed the effect of estradiol and of two classes of antiestrogens on the morphology of the MCF7 human breast cancer cell line by scanning and transmission electron microscopy. Estradiol progressively increased the number and the length of microvilli at the cell surface. The density of the microvilli network ... | [
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10,004,232 | Pediatric cancer and nutrition workshop. | [
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10,004,233 | Pediatric cancer and nutrition workshop: introductory comments. | [
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10,004,234 | Nutritional assessment of the child with cancer. | [
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10,004,235 | Children with cancer are in need of nutritional support to combat the catabolic effects of malignant tumors and debilitation from surgical or other treatment and complicating infections and to maintain their immune system and other host defenses to combat cancer and infection. Also, growth must be supported in the chil... | [
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10,004,236 | Pathophysiology of cancer cachexia: current understanding and areas for future research. | [
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10,004,237 | Weight loss and failure to gain weight normally in cancer patients are attributable to negative energy balance and altered metabolism. Energy balance is negative because of decreased intake, increased expenditure, or both. Changes in carbohydrate metabolism include glucose uptake and lactate production by tumor, relati... | [
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10,004,238 | Tumoricidal potential of nutritional manipulations. | [
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10,004,239 | Perturbations of specific nutrient availability is the basis of a large number of chemotherapeutic modalities used in cancer treatment. The creation of transient nutrient deprivation states by deficient diets (deficiency), nutrient destruction or displacement (depletion), the presence of antimetabolites or analogs (def... | [
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10,004,240 | Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU. | [
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10,004,241 | Fifty-seven patients were treated with continuous infusion of PALA at a dose of 850 mg/m2/day x 5 and iv bolus injection of 5-FU at a dose of 300 mg/m2/day x 5, which was given at the end of each 24-hour PALA infusion; the treatment interval was 28 days. The overall response rate among 43 evaluable patients was 14%. Tw... | [
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10,004,242 | Vindesine in the treatment of squamous cell carcinoma, adenocarcinoma, and large cell carcinoma of the lung. | [
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10,004,243 | The antineoplastic activity of vindesine was evaluated in a phase II trial in patients with squamous cell carcinoma, adenocarcinoma, and large cell carcinoma of the lung. Sixty-three patients participated in the trial: 22 with squamous cell carcinoma, 25 with adenocarcinoma, and 16 with large cell carcinoma. Most of th... | [
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10,004,244 | Isolation and properties of Chinese hamster lung cells resistant to ellipticine derivatives. | [
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10,004,245 | Chinese hamster lung cells resistant to 9-OH-ellipticine (9-OH-E) were selected in vitro by adding stepwise increasing drug concentrations to the cell growth medium. This selection procedure resulted in the isolation of two sublines, about tenfold and 12-fold resistant to 9-OH-E. This level of resistance did not increa... | [
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10,004,246 | Biochemical and pharmacologic properties of a new folate analog, 10-deaza-aminopterin, in mice. | [
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0.044942... |
10,004,247 | Phase II study of a high-dose regimen of cyclophosphamide and prednisolone in advanced non-Hodgkin's lymphoma of favorable histologic type. | [
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-0.0239042... |
10,004,248 | Fifty-seven courses of cyclophosphamide (2.5-5.0 g/m2) and prednisolone (1.0 g/m2 x 5) were given to 22 patients with advanced stage IV non-Hodgkin's lymphoma of favorable histology. Six patients (27%) had a complete response (CR) (median duration, 10.1 months), and six (27%) had a partial response (median duration, 3.... | [
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10,004,249 | Phase II study of anguidine in gastrointestinal malignancies: a Southwest Oncology Group study. | [
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0.0062444... |
10,004,250 | The Southwest Oncology Group conducted a phase II study of anguidine in 134 patients with gastrointestinal malignancies. Anguidine was administered as a 4-hour infusion at doses of 3.0 and 4.5 mg/m2 daily x 5. Response rates for patients with colon carcinoma were 22% (four of 18 patients without previous chemotherapy) ... | [
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10,004,251 | Chemoimmunotherapy for autochthonous acute rat leukemias. | [
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0.0346... |
10,004,252 | Eighty autochthonous acute rat leukemias that had been induced by ethylnitrosourea were used to compare the effect of single-drug therapy with vincristine, doxorubicin, or cytarabine with the effect of combination therapy using these three drugs with or without BCG-Pasteur F. The combination chemotherapy was clearly su... | [
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10,004,253 | Comparative cardiac and renal toxicity of daunorubicin in the rat and rabbit. | [
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10,004,254 | A direct comparison of the cardiac and extracardiac effects of repeated daunorubicin administration in the rat and rabbit demonstrated a basic similarity in the cardiac myocyte response. The rat, however, appears to develop a more severe drug-related nephropathy, resulting in widespread soft tissue mineralization that ... | [
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0.1418779641... |
10,004,255 | Phase II evaluation of VM-26 in patients with metastatic transitional cell carcinoma of the urinary tract: an Eastern Cooperative Oncology Group study. | [
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10,004,256 | Synthesis of L-idaro-1,4-lactone, an inhibitor of alpha-L-idosiduronase. | [
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0.05... |
10,004,257 | L-idaro-1,4-lactone was synthesized by two different, published methods: (1) epimerization of monopotassium D-glucarate by refluxing in aqueous barium hydroxide, and (2) oxidation of L-iditol by heating in dilute nitric acid. The lactone, formed by heat dehydration from aqueous solution at low pH, was purified by paper... | [
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0.0442... |
10,004,258 | Methyl derivatives of 2-acetamido-2-deoxy-3-O-(beta-D-glucopyranosyluronic acid)-D-glucose (hyalobiouronic acid) from methylated hyaluronic acid. | [
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-0.05775150... |
10,004,259 | Methanolysis of methylated hyaluronic acid, followed by acetylation, gave, in 70% yield, crystalline methyl 2-acetamido-2-deoxy-4,6-di-O-methyl-3-O-(methyl 4-O-acetyl-2,3-di-O-methyl-beta-D-glucopyranosyluronate) -alpha-D-glucopyranoside. Removal of the O-acetyl and methyl ester groups gave compounds that are useful in... | [
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10,004,260 | [Health policy and tasks for medical science after the 16th Congress of the Czechoslovak Communist Party]. | [
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0.02... |
10,004,261 | [Renal osteopathy in patients receiving regular haemodialysis (author's transl)]. | [
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0.015916733071208,
0.017834123224020004,
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0.0878719761967659,
-0.0032566881272941828,
-0.055... |
10,004,262 | [Physical perfection, physical fitness and exercise]. | [
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0.042361047118902206,
0.05462558940052986,
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0.013253003358840942,
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-0.08813... |
10,004,263 | [Electrocapacitance vulvoplethysmography (author's transl)]. | [
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0.031071443110704422,
0.06995470076799393,
0.0011429638834670186,
0.012590732425451279,
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0.061277974396944046,
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0.043370675295591354,
0.0925... |
10,004,264 | [Intensive physical training and its effect on the urine excretion of catecholamines and 17-OH corticoids during aerobic exercise on an ergometer (author's transl)]. | [
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-0.00393358338624239,
-0.07682621479034424,
0.... |
10,004,265 | [The effect of environment and physical exercise on red blood count in elite female swimmers (author's transl)]. | [
0.007796012796461582,
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0.0... |
10,004,266 | [Pedagogical training of medical school teachers in the USSR (author's transl)]. | [
-0.015176936984062195,
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0.04520991072058678,
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0.1173814982175827,
-0.03645557165145874,
0.0517... |
10,004,267 | [Medical students' attitudes to examinations (author's transl)]. | [
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0.00707220... |
10,004,268 | Penetration of the peritrophic membrane of the tick by Babesia microti. | [
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0... |
10,004,269 | A peritrophic membrane (PM) has been demonstrated in the gut of feeding larvae, nymphs, and adults of the tick Ixodes dammini. This is the first report of a PM in ticks. This temporary structure divides the lumen of the gut into two compartments, an endoperitrophic space, the lumen proper, and an ectoperitrophic space ... | [
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0.04... |
10,004,270 | Glucagon and glicentin immunoreactive cells in human colon. | [
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0.03... |
10,004,271 | An immunohistochemical study of glucagon and glicentin immunoreactive endocrine cells in the human colon epithelium was performed. Serial sections and qualitative analysis show a cell population containing both immunoreactivities. However, there is another cell population exhibiting only an immunoreactivity with glicen... | [
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0.00066... |
10,004,272 | Marked reduction in intramembranous particle clusters in the terminal portion of inner medullary collecting ducts of antidiuretic rats. | [
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0.019581584259867668,
0.045... |
10,004,273 | Antidiuretic hormone (ADH) induces an aggregation of intramembranous particles (IMP) into discrete clusters in the luminal plasma membrane of rat renal papillary collecting duct cells (Harmanci et al. 1978). The correlation between an elevated dose of ADH, increased urine osmolality, and greater IMP cluster frequency h... | [
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0.00462269876152277,
0.037990... |
10,004,274 | Fine structural examination of the single heart tube in the fifteen day ferret embryo. | [
0.018680645152926445,
0.04395465925335884,
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0.008082381449639797,
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0.... |
10,004,275 | The different segments of the embryonic heart tube of the ferret were examined with light and transmission electron microscopy. The cells of bulbus cordis, bulboventricular junction, primitive ventricle, atrioventricular junction, and primitive atria were in the process of differentiating into myocardial cells. The ven... | [
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0.0... |
10,004,276 | VIP (vasoactive intestinal polypeptide)--immunoreactive innervation of the portal vein. | [
0.03025728277862072,
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0.020442523062229156,
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-0.07687472552061081,
0.03795... |
10,004,277 | Nerve fibres displaying immunoreactivity for vasoactive intestinal polypeptide (VIP) were found in the wall of the portal vein in cats, guinea pigs, rats and mice. In whole-mount preparations a sparse network of VIP fibres was seen in the vessel wall. Electrical field stimulation of the rat portal vein in vitro caused ... | [
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0.02143489569425583,
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0.066371... |
10,004,278 | Comparison between temperature-induced changes and effects caused by dark/light adaptation in the eyes of two species of Antarctic crustaceans. | [
0.04412900283932686,
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0.05473225563764572,
-0.025... |
10,004,279 | The amphipod, Orchomene plebs, and the isopod, Glyptonotus antarcticus, both adapted to live in seawater of a temperature of -2 degree to 0 degree C, were kept for 7h at the unphysiologically high temperature of +10 degree C. Temperature elevation appeared to mimic light adaptation with regard to the position of the sc... | [
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0.032872721552848816,
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0.0... |
10,004,280 | Ultrastructural study of the epithelial mucous cells in lizards (Lacertilia). | [
0.0220420490950346,
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0.02743886224925518,
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0.076103... |
10,004,281 | An ultrastructural study of the mucous cells of the intestinal epithelium of four lacertilian species (Lacerta lepida, Lacerta hispanica, Psammodromus algirus and Acanthodactylus erythrurus) is here reported. Two types of mucous cells have been found in these species: common mucous cells and granular mucous cells. Imma... | [
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0.0... |
10,004,282 | Transmission and scanning electron-microscopic observations on tanycytes in the mediobasal hypothalamus and the median eminence of adrenalectomized rats. | [
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0.02831515... |
10,004,283 | Tanycytes in the median eminence (ME) of the rat exhibit morphological features suggesting their possible participation in transport phenomena. After adrenalectomy, which modifies the hypothalamo-hypophyseal axis, they undergo morphological changes characterized by an accumulation of lipid droplets, an increased number... | [
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0.0355... |
10,004,284 | Phagocytosis of erythrocytes in the subarachnoid space at spinal nerve exits. | [
0.05968663841485977,
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0.046611... |
10,004,285 | After intracisternal injection of heparinised autologous blood in cats, spinal nerve exits (SNE) of the subarachnoid space (SAS) were examined by scanning and transmission electron microscopy. Phagocytes, erythrocytes and erythrophages (= macrophages which had phagocytosed red blood cells) were found at SNE. Some linin... | [
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0.005047130398452282,
0.06353... |
10,004,286 | The effect of ploidy and colcemid on the frequency of spontaneous transformation of cultured cells. | [
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0.02190389484167099,
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-0.00... |
10,004,287 | Variations in chromosome numbers and their possible relationship to the development of 8-azaguanine resistance in V79 Chinese hamster cells. | [
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0.02... |
10,004,288 | Further purification of an inhibitory factor for DNA synthesis in regenerating rat liver. | [
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0.041225556284189224,
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10,004,289 | Stimulation of nucleologenesis by adenosine. | [
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0.... |
10,004,290 | Surface activity and human blood platelet aggregation-inhibitory potency. | [
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0.032... |
10,004,291 | Surface and interfacial activity is correlated with molecular constitution and inhibitory potency of mono- and bis(carbamoylpiperidino)alkanes and aralkanes, and of some corresponding quaternary pyridinium congeners, in ADP-induced human blood platelet aggregation. The measurements of surface and interfacial tension we... | [
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0.08447... |
10,004,292 | Molecular interaction of acrylonitrile and potassium cyanide with rat blood. | [
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0.10... |
10,004,293 | The interaction of acrylonitrile (VCN) with rat blood has been investigated at the molecular level in an attempt to understand the possible mechanism of its toxicity. The results obtained were compared to those with potassium cyanide (KCN), a compound known to liberate cyanide (CN-) in biologic conditions. The radioact... | [
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0.09... |
10,004,294 | Fungal oxidation of 3-methylcholanthrene: formation of proximate carcinogenic metabolites of 3-methylcholanthrene. | [
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10,004,295 | The filamentous fungus, Cunninghamella elegans, was found to metabolize the potent carcinogen, 3-methylcholanthrene (3-MC) to 1-hydroxy-3-MC, 2-hydroxy-3-MC, 1-keto-3-MC, 2-keto-3-MC and trans-9,10-dihydrodiols of 1-hydroxy-3-MC. In addition several unidentified derivatives of 3-MC were found. The metabolites formed we... | [
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0.04994358867406845,
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10,004,296 | Chromatographic resolution of amino acid adducts of aliphatic halides. | [
0.0077536688186228275,
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0.09472228586673737,
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0.013244511559605598,
-0.028... |
10,004,297 | Numerous xenobiotics are known to be bioactivated and to covalently and to proteins, but the resulting amino acid adducts (AAAs) are unknown. In this study the AAAs of twelve 14C-labeled aliphatic halides were examined after formation in an in vitro microsomal system. After exhaustive solvent extraction of the precipit... | [
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0.09601718932390213,
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0.012158753350377083,
0.0990482... |
10,004,298 | Stereoselective metabolism of the optical isomers of trans-1,2-dihydroxy-1,2-dihydrophenanthrene to bay-region diol epoxides by rat liver microsomes. | [
0.0057570901699364185,
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0.025323543697595596,
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-0.07694979012012482,
0.0110... |
10,004,299 | Potential identification of chemical carcinogens in a viral transformation system. | [
0.03604326769709587,
0.006645414046943188,
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0.02102186344563961,
-0.06906278431415558,
0.021034978330135345,
0.0707598328590393,
0.0150245... |
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